AI Generator Uses Water

AI Generator Uses Water — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

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  Local Economic Assessment Package

  The Local Economic Assessment Package (also known as “EDR-LEAP” or “LEAP Model”) is a web-based, interactive database and software tool used by local and regional agencies in the US to improve strategies for economic development. It provides local economic performance measures, and benchmarks for comparison of economic development factors against competing regions. It works by incorporating elements of economic base analysis as well as gap analysis and business cluster analysis to identify needs for improvement and paths for economic growth. The LEAP Model was originally developed for the Appalachian Regional Commission. Its theory and applications are discussed in peer-reviewed journal articles.

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  Training, validation, and test data sets

  In machine learning, a common task is the study and construction of algorithms that can learn from and make predictions on data. Such algorithms function by making data-driven predictions or decisions, through building a mathematical model from input data. These input data used to build the model are usually divided into multiple data sets. In particular, three data sets are commonly used in different stages of the creation of the model: training, validation, and testing sets. The model is initially fit on a training data set, which is a set of examples used to fit the parameters (e.g. weights of connections between neurons in artificial neural networks) of the model. The model (e.g. a naive Bayes classifier) is trained on the training data set using a supervised learning method, for example using optimization methods such as gradient descent or stochastic gradient descent. In practice, the training data set often consists of pairs of an input vector (or scalar) and the corresponding output vector (or scalar), where the answer key is commonly denoted as the target (or label). The current model is run with the training data set and produces a result, which is then compared with the target, for each input vector in the training data set. Based on the result of the comparison and the specific learning algorithm being used, the parameters of the model are adjusted. The model fitting can include both variable selection and parameter estimation. Successively, the fitted model is used to predict the responses for the observations in a second data set called the validation data set. The validation data set provides an unbiased evaluation of a model fit on the training data set while tuning the model's hyperparameters (e.g. the number of hidden units—layers and layer widths—in a neural network). Validation data sets can be used for regularization by early stopping (stopping training when the error on the validation data set increases, as this is a sign of over-fitting to the training data set). This simple procedure is complicated in practice by the fact that the validation data set's error may fluctuate during training, producing multiple local minima. This complication has led to the creation of many ad-hoc rules for deciding when over-fitting has truly begun. Finally, the test data set is a data set used to provide an unbiased evaluation of a model fit on the training data set. When the data in the test data set has never been used (for example in cross-validation), the test data set is called a holdout data set. The term "validation set" is sometimes used instead of "test set" in some literature (e.g., if the original data set was partitioned into only two subsets, the test set might be referred to as the validation set). Deciding the sizes and strategies for data set division in training, test and validation sets is very dependent on the problem and data available. == Training data set == A training data set is a data set of examples used during the learning process and is used to fit the parameters (e.g., weights) of, for example, a classifier. For classification tasks, a supervised learning algorithm looks at the training data set to determine, or learn, the optimal combinations of variables that will generate a good predictive model. The goal is to produce a trained (fitted) model that generalizes well to new, unknown data. The fitted model is evaluated using “new” examples from the held-out data sets (validation and test data sets) to estimate the model’s accuracy in classifying new data. To reduce the risk of issues such as over-fitting, the examples in the validation and test data sets should not be used to train the model. Most approaches that search through training data for empirical relationships tend to overfit the data, meaning that they can identify and exploit apparent relationships in the training data that do not hold in general. When a training set is continuously expanded with new data, then this is incremental learning. == Validation data set == A validation data set is a data set of examples used to tune the hyperparameters (i.e. the architecture) of a model. It is sometimes also called the development set or the "dev set". An example of a hyperparameter for artificial neural networks includes the number of hidden units in each layer. It, as well as the testing set (as mentioned below), should follow the same probability distribution as the training data set. In order to avoid overfitting, when any classification parameter needs to be adjusted, it is necessary to have a validation data set in addition to the training and test data sets. For example, if the most suitable classifier for the problem is sought, the training data set is used to train the different candidate classifiers, the validation data set is used to compare their performances and decide which one to take and, finally, the test data set is used to obtain the performance characteristics such as accuracy, sensitivity, specificity, F-measure, and so on. The validation data set functions as a hybrid: it is training data used for testing, but neither as part of the low-level training nor as part of the final testing. The basic process of using a validation data set for model selection (as part of training data set, validation data set, and test data set) is: Since our goal is to find the network having the best performance on new data, the simplest approach to the comparison of different networks is to evaluate the error function using data which is independent of that used for training. Various networks are trained by minimization of an appropriate error function defined with respect to a training data set. The performance of the networks is then compared by evaluating the error function using an independent validation set, and the network having the smallest error with respect to the validation set is selected. This approach is called the hold out method. Since this procedure can itself lead to some overfitting to the validation set, the performance of the selected network should be confirmed by measuring its performance on a third independent set of data called a test set. An application of this process is in early stopping, where the candidate models are successive iterations of the same network, and training stops when the error on the validation set grows, choosing the previous model (the one with minimum error). == Test data set == A test data set is a data set that is independent of the training data set, but that follows the same probability distribution as the training data set. A test set is therefore a set of examples used only to assess the performance (i.e. generalization) of a specified classifier on unseen data. To do this, the model is used to predict classifications of examples in the test set. Those predictions are compared to the examples' true classifications to assess the model's accuracy. If a model fit to the training and validation data set also fits the test data set well, minimal overfitting has taken place (see figure below). A better fitting of the training or validation data sets as opposed to the test data set usually points to overfitting. In the scenario where a data set has a low number of samples, it is usually partitioned into a training set and a validation data set, where the model is trained on the training set and refined using the validation set to improve accuracy, but this approach will lead to overfitting. The holdout method can also be employed, where the test set is used at the end, after training on the training set. Other techniques, such as cross-validation and bootstrapping, are used on small data sets. The bootstrap method generates numerous simulated data sets of the same size by randomly sampling with replacement from the original data, allowing the random data points to serve as test sets for evaluating model performance. Cross-validation splits the data set into multiple folds, with a single sub-fold used as test data; the model is trained on the remaining folds, and all folds are cross-validated (with results averaged and models consolidated) to estimate final model performance. Note that some sources advise against using a single split, as it can lead to overfitting as well as biased model performance estimates. For this reason, data sets are split into three partitions: training, validation and test data sets. The standard machine learning practice is to train on the training set and tune hyperparameters using the validation set, where the validation process selects the model with the lowest validation loss, which is then tested on the test data set (normally held out) to assess the final model. The holdout method for the test set reduces computation by avoiding using the test set after each epoch. The test data set should never be used for validating the training model or fine-tuning hyperparameters, as it provides an accurate and honest evaluation of the model's final performance on unseen dat

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  Defining length

  In the field of genetic algorithms, a schema (plural: schemata) is a template that represents a subset of potential solutions. These templates use fixed symbols (e.g., `0` or `1`) for specific positions and a wildcard or "don't care" symbol (often `#` or ``) for others. The defining length of a schema, denoted as L(H), measures the distance between the outermost fixed positions in the template. According to the Schema theorem, a schema with a shorter defining length is less likely to be disrupted by the genetic operator of crossover. As a result, short schemata are considered more robust and are more likely to be propagated to the next generation. In genetic programming, where solutions are often represented as trees, the defining length is the number of links in the minimum tree fragment that includes all the non-wildcard symbols within a schema H. == Example == The defining length is calculated by subtracting the position of the first fixed symbol from the position of the last one. Using 1-based indexing for a string of length 5: The schema `1##0#` has its first fixed symbol (`1`) at position 1 and its last fixed symbol (`0`) at position 4. Its defining length is 4 − 1 = 3. The schema `00##0` has its first fixed symbol at position 1 and its last at position 5. Its defining length is 5 − 1 = 4. The schema `##0##` has only one fixed symbol at position 3. The first and last fixed positions are the same, so its defining length is 3 − 3 = 0.

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  Soft independent modelling of class analogies

  Soft independent modelling by class analogy (SIMCA) is a statistical method for supervised classification of data. The method requires a training data set consisting of samples (or objects) with a set of attributes and their class membership. The term soft refers to the fact the classifier can identify samples as belonging to multiple classes and not necessarily producing a classification of samples into non-overlapping classes. == Method == In order to build the classification models, the samples belonging to each class need to be analysed using principal component analysis (PCA); only the significant components are retained. For a given class, the resulting model then describes either a line (for one Principal Component or PC), plane (for two PCs) or hyper-plane (for more than two PCs). For each modelled class, the mean orthogonal distance of training data samples from the line, plane, or hyper-plane (calculated as the residual standard deviation) is used to determine a critical distance for classification. This critical distance is based on the F-distribution and is usually calculated using 95% or 99% confidence intervals. New observations are projected into each PC model and the residual distances calculated. An observation is assigned to the model class when its residual distance from the model is below the statistical limit for the class. The observation may be found to belong to multiple classes and a measure of goodness of the model can be found from the number of cases where the observations are classified into multiple classes. The classification efficiency is usually indicated by Receiver operating characteristics. In the original SIMCA method, the ends of the hyper-plane of each class are closed off by setting statistical control limits along the retained principal components axes (i.e., score value between plus and minus 0.5 times score standard deviation). More recent adaptations of the SIMCA method close off the hyper-plane by construction of ellipsoids (e.g. Hotelling's T2 or Mahalanobis distance). With such modified SIMCA methods, classification of an object requires both that its orthogonal distance from the model and its projection within the model (i.e. score value within the region defined by the ellipsoid) are not significant. == Application == SIMCA as a method of classification has gained widespread use especially in applied statistical fields such as chemometrics and spectroscopic data analysis.

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  Office automation

  Office automation refers to the varied computer machinery and software used to digitally create, collect, store, manipulate, and relay office information needed for accomplishing basic tasks. Raw data storage, electronic transfer, and the management of electronic business information comprise the basic activities of an office automation system. Office automation helps in optimizing or automating existing office procedures. The backbone of office automation is a local area network, which allows users to transfer data, mail and voice across the network. All office functions, including dictation, typing, filing, copying, fax, telex, microfilm and records management, telephone and telephone switchboard operations, fall into this category. Office automation was a popular term in the 1970s and 1980s as the desktop computer exploded onto the scene. Advantages of office automation include that it can get many tasks accomplished faster, it eliminates the need for a large staff, less storage is required to store data, and multiple people can update data simultaneously in the event of changes in schedule. == Outline == Businesses can easily purchase and stock their wares with the aid of technology. Many of the manual tasks that used to be done by hand can now be done through hand held devices and UPC and SKU coding. In the retail setting, automation also increases choice. Customers can easily process their payments through automated credit card machines and no longer have to wait in line for an employee to process and manually type in the credit card numbers. Office payrolls have been automated, which means no one has to manually cut checks, and those checks that are cut can be printed through computer programs. Direct deposit can be automatically set up and this further reduces the manual process, and most employees who participate in direct deposit often find their paychecks come earlier than if they'd have to wait for their checks to be written and then cleared by the bank. Other ways automation has reduced employee manpower on tasks is automated voice direction. Through the use of prompts, automated phone menus and directed calls, the need for employees to be dedicated to answer the phones has been reduced, and in some cases, eliminated.

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  IDistance

  In pattern recognition, iDistance is an indexing and query processing technique for k-nearest neighbor queries on point data in multi-dimensional metric spaces. The kNN query is one of the hardest problems on multi-dimensional data, especially when the dimensionality of the data is high. iDistance is designed to process kNN queries in high-dimensional spaces efficiently and performs extremely well for skewed data distributions, which usually occur in real-life data sets. iDistance employs a two-phase search strategy involving an initial filtering of candidate regions and a subsequent refinement of results, an approach aligned with the Filter and Refine Principle (FRP). This means that the index first prunes the search space to eliminate unlikely candidates, then verifies the true nearest neighbors in a refinement step, following the general FRP paradigm used in database search algorithms. The iDistance index can also be augmented with machine learning models to learn data distributions for improved searching and storage of multi-dimensional data. == Indexing == Building the iDistance index has two steps: A number of reference points in the data space are chosen. There are various ways of choosing reference points. Using cluster centers as reference points is the most efficient way. The data points are partitioned into Voronoi cells based on well-chosen reference points. The distance between a data point and its closest reference point is calculated. This distance plus a scaling value is called the point's iDistance. By this means, points in a multi-dimensional space are mapped to one-dimensional values, and then a B+-tree can be adopted to index the points using the iDistance as the key. The figure on the right shows an example where three reference points (O1, O2, O3) are chosen. The data points are then mapped to a one-dimensional space and indexed in a B+-tree. Various extensions have been proposed to make the selection of reference points for effective query performance, including employing machine learning to learn the identification of reference points. == Query processing == To process a kNN query, the query is mapped to a number of one-dimensional range queries, which can be processed efficiently on a B+-tree. In the above figure, the query Q is mapped to a value in the B+-tree while the kNN search ``sphere" is mapped to a range in the B+-tree. The search sphere expands gradually until the k NNs are found. This corresponds to gradually expanding range searches in the B+-tree. The iDistance technique can be viewed as a way of accelerating the sequential scan. Instead of scanning records from the beginning to the end of the data file, the iDistance starts the scan from spots where the nearest neighbors can be obtained early with a very high probability. == Applications == The iDistance has been used in many applications including Image retrieval Video indexing Similarity search in P2P systems Mobile computing Recommender system == Historical background == The iDistance was first proposed by Cui Yu, Beng Chin Ooi, Kian-Lee Tan and H. V. Jagadish in 2001. Later, together with Rui Zhang, they improved the technique and performed a more comprehensive study on it in 2005.

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  Ground truth

  Ground truth is information that is known to be real or true, provided by direct observation and measurement (i.e. empirical evidence) as opposed to information provided by inference. The term ground truth appeared in remote sensing literature as early as 1972, when NASA described it as essential "data about ... materials on the earth's surface" used to calibrate measurements. It was later adopted by the statistical modeling and machine learning communities. == Etymology == The Oxford English Dictionary (s.v. ground truth) records the use of the word Groundtruth in the sense of 'fundamental truth' from Henry Ellison's poem "The Siberian Exile's Tale", published in 1833. == Usage == The term "ground truth" can be used as a noun, adjective, and verb. Noun: "ground truth" (no hyphen). Example: "The ground truth is essential for training accurate models." Adjective: "ground-truth" (hyphenated compound adjective). Example: "We need to use ground-truth data to validate the model." Verb: "to ground-truth" or "to groundtruth" (compound verb,). Example: "We need to ground-truth the results to ensure their accuracy." == Statistics and machine learning == In statistics and machine learning, ground truth is the ideal expected result, used in statistical models to prove or disprove research hypotheses. "Ground truthing" is the process of gathering the good data for this test. Ground truth is typically included in labeled data. In machine learning, "ground truth" is not necessarily objectively correct or true. For example, in training AI models or relevance rankers, it may be a set of judgments made by people or inferred from user behavior, which may depend on context. For example, in Bayesian spam filtering, a supervised learning system is typically trained by examples labeled as spam and non-spam. Although these labels may be subjective or inaccurate, they are considered ground truth. True ground truth in machine learning is objective data. For example, suppose we are testing a stereo vision system to see how well it can estimate 3D positions. A calibrated laser rangefinder may provide accurate distances as ground truth. == Remote sensing == In remote sensing, "ground truth" refers to information collected at the imaged location. Ground truth allows image data to be related to real features and materials on the ground. The collection of ground truth data enables calibration of remote-sensing data, and aids in the interpretation and analysis of what is being sensed. Examples include cartography, meteorology, analysis of aerial photographs, satellite imagery and other techniques in which data are gathered at a distance. More specifically, ground truth may refer to a process in which "pixels" on a satellite image are compared to what is imaged (at the time of capture) in order to verify the contents of the "pixels" in the image (noting that the concept of "pixel" is imaging-system-dependent). In the case of a classified image, supervised classification can help to determine the accuracy of the classification by the remote sensing system which can minimize error in the classification. Ground truth is usually done on site, correlating what is known with surface observations and measurements of various properties of the features of the ground resolution cells under study in the remotely sensed digital image. The process also involves taking geographic coordinates of the ground resolution cell with GPS technology and comparing those with the coordinates of the "pixel" being studied provided by the remote sensing software to understand and analyze the location errors and how it may affect a particular study. Ground truth is important in the initial supervised classification of an image. When the identity and location of land cover types are known through a combination of field work, maps, and personal experience these areas are known as training sites. The spectral characteristics of these areas are used to train the remote sensing software using decision rules for classifying the rest of the image. These decision rules such as Maximum Likelihood Classification, Parallelopiped Classification, and Minimum Distance Classification offer different techniques to classify an image. Additional ground truth sites allow the remote sensor to establish an error matrix that validates the accuracy of the classification method used. Different classification methods may have different percentages of error for a given classification project. It is important that the remote sensor chooses a classification method that works best with the number of classifications used while providing the least amount of error. Ground truth also helps with atmospheric correction. Since images from satellites have to pass through the atmosphere, they can get distorted because of absorption in the atmosphere. So ground truth can help fully identify objects in satellite photos. === Errors of commission === An example of an error of commission is when a pixel reports the presence of a feature (such a tree) that, in reality, is absent (no tree is actually present). Ground truthing ensures that the error matrices have a higher accuracy percentage than would be the case if no pixels were ground-truthed. This value is the complement of the user's accuracy, i.e. Commission Error = 1 - user's accuracy. === Errors of omission === An example of an error of omission is when pixels of a certain type, for example, maple trees, are not classified as maple trees. The process of ground-truthing helps to ensure that the pixel is classified correctly and the error matrices are more accurate. This value is the complement of the producer's accuracy, i.e. Omission Error = 1 - producer's accuracy == Geographical information systems == In GIS the spatial data is modeled as field (like in remote sensing raster images) or as object (like in vectorial map representation). They are modeled from the real world (also named geographical reality), typically by a cartographic process (illustrated). Geographic information systems such as GIS, GPS, and GNSS, have become so widespread that the term "ground truth" has taken on special meaning in that context. If the location coordinates returned by a location method such as GPS are an estimate of a location, then the "ground truth" is the actual location on Earth. A smart phone might return a set of estimated location coordinates such as 43.87870, −103.45901. The ground truth being estimated by those coordinates is the tip of George Washington's nose on Mount Rushmore. The accuracy of the estimate is the maximum distance between the location coordinates and the ground truth. We could say in this case that the estimate accuracy is 10 meters, meaning that the point on Earth represented by the location coordinates is thought to be within 10 meters of George's nose—the ground truth. In slang, the coordinates indicate where we think George Washington's nose is located, and the ground truth is where it really is. In practice a smart phone or hand-held GPS unit is routinely able to estimate the ground truth within 6–10 meters. Specialized instruments can reduce GPS measurement error to under a centimeter. == Military usage == US military slang uses "ground truth" to refer to the facts comprising a tactical situation—as opposed to intelligence reports, mission plans, and other descriptions reflecting the conative or policy-based projections of the industrial·military complex. The term appears in the title of the Iraq War documentary film The Ground Truth (2006), and also in military publications, for example Stars and Stripes saying: "Stripes decided to figure out what the ground truth was in Iraq."

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  ARKA descriptors in QSAR

  In computational chemistry and cheminformatics, ARKA descriptors in QSAR are a class of molecular descriptors used in quantitative structure–activity relationship (QSAR) modeling (or related approaches such as QSPR and QSTR), a computational method for predicting the biological activity or toxicity of chemical compounds based on their molecular structure. Molecular descriptors are numerical values that summarize information about a molecule's structure, topology, geometry, or physicochemical properties in a form suitable for machine learning or statistical modeling. ARKA (Arithmetic Residuals in K-Groups Analysis) descriptors differ from traditional descriptors by encoding atomic-level information through recursive autoregression techniques, which aim to capture subtle structural patterns and improve predictive accuracy. They are designed to be both interpretable and well-suited to modeling nonlinear relationships in QSAR studies. == Comparisons == While QSAR is essentially a similarity-based approach, the occurrence of activity/property cliffs may greatly reduce the predictive accuracy of the developed models. The novel Arithmetic Residuals in K-groups Analysis (ARKA) approach is a supervised dimensionality reduction technique developed by the DTC Laboratory, Jadavpur University that can easily identify activity cliffs in a data set. Activity cliffs are similar in their structures but differ considerably in their activity. The basic idea of the ARKA descriptors is to group the conventional QSAR descriptors based on a predefined criterion and then assign weightage to each descriptor in each group. ARKA descriptors have also been used to develop classification-based and regression-based QSAR models with acceptable quality statistics. The ARKA descriptors have been used for the identification of activity cliffs in QSAR studies and/or model development by multiple researchers. A tutorial presentation on the ARKA descriptors is available. Recently a multi-class ARKA framework has been proposed for improved q-RASAR model generation.

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  Verbal overshadowing

  Verbal overshadowing is a phenomenon where giving a verbal description of sensory input impairs formation of memories of that input. This was first reported by Schooler and Engstler-Schooler (1990) where it was shown that the effects can be observed across multiple domains of cognition which are known to rely on non-verbal knowledge and perceptual expertise. One example of this is memory, which has been known to be influenced by language. Seminal work by Carmichael and collaborators (1932) demonstrated that when verbal labels are connected to non-verbal forms during an individual's encoding process, it could potentially bias the way those forms are reproduced. Because of this, memory performance relying on reportable aspects of memory that encode visual forms should be vulnerable to the effects of verbalization. == Initial findings == Schooler and Engstler-Schooler (1990) were the first to report findings of verbal overshadowing. In their study, participants watched a video of a simulated robbery and were instructed to either verbally describe the robber or engage in a control task. Those who engaged in giving a verbal description were less likely to correctly identify the robber from a test lineup, compared to those who engaged in the control task. A larger effect was detected when the verbal description was provided 20, rather than 5, minutes after the video, and immediately before the test lineup. A meta-analysis by Meissner and Brigham (2001) supported the effects of verbal overshadowing, showing a small but reliably negative effect. == General effects of verbal overshadowing == The effects of verbal overshadowing have been generalized across multiple domains of cognition that are known to rely on non-verbal knowledge and perceptual expertise, such as memory. Memory has been known to be influenced by language. Seminal work by Carmichael and collaborators (1932) demonstrated that labels attached to, or associated with, non-verbal forms during memory encoding can affect the way the forms were subsequently reproduced. Because of this, memory performance that relies on reportable aspects of memory that encode visual forms should be vulnerable to the effects of verbalization. Pelizzon, Brandimonte, and Luccio (2002) found that visual memory representations appear to incorporate visual, spatial, and temporal characteristics. It is explained as follows: With the temporal code (where the only information available is the sequence of the stimuli), performance levels remain high, unless participants are required to retrieve the stimuli in a different order from that used at encoding (visual cue). In this case, performance is significantly impaired, even in the presence of a visual cue. The study showed that order information acts as a link between the two separate representations of figure and background, hence preventing verbal overshadowing at encoding (temporal component) or attenuating its influence at retrieval (spatial component).(p. 960) Hatano, Ueno, Kitagami, and Kawaguchi found that verbal overshadowing is likely to occur when participants verbally described targets in detail. Detailed verbal descriptions resulted in more frequently inaccurate descriptions that in turn created inaccurate representations in the memories of participants. Inaccuracies are also likely to occur when face recognition comes immediately after verbalization. Other forms of non-verbal knowledge affected by verbal overshadowing include the following: [Verbal overshadowing] has also been observed when participants attempt to generate descriptions of other 'difficult-to-describe' stimuli such as colors (Schooler and Engstler-Schooler, 1990) or abstract figures (Brandimonte et al., 1997), or other non-visual tasks such as wine tasting (Melcher and Schooler, 1996), decision making (Wilson and Schooler, 1991), and insight problem-solving. (p. 871) (Schooler et al., 1993) Verbalization of stimuli leads to the disruption of non-reportable processes that are necessary for achieving insight solutions, which are distinct from language processes. Schooler, Ohlsson, and Brooks (1993) found that face recognition requires information that cannot be adequately verbalized, giving rise to difficulty in describing factors in recognition judgments. Subjects were less effective in solving insight problems when compelled to put their thoughts in words, which suggests that language may interfere with thought. The verbal overshadowing effect was not seen when participants engaged in articulatory suppression. Performance was reduced in both the verbal and non-verbal description conditions. This is evidence that verbal encoding plays a role in face recognition. By testing with distracting faces presented between study and test, Lloyd-Jones and Brown (2008) suggested a dual-process approach to recognition memory took place, that verbalization influenced familiarity-based processes at first, but its effects were later seen on recollection, when discrimination between items became more difficult. == Verbal overshadowing in facial recognition == The verbal overshadowing effect can be found for facial recognition because faces are predominately processed in a holistic or configurable manner. (Tanaka & Farah, 1993; Tanaka & Sengco, 1997) Verbalizing one's memory for a face is done using a featural or analytic strategy, leading to a drift from the configurable information about the face and to impaired recognition performance. However, Fallshore & Schooler (1995) found that the verbal overshadowing effect was not found when participants described faces of races different from their own. A study by Brown and Lloyd-Jones (2003) found that there was no verbal overshadowing effect found in car descriptions; it was only seen in facial descriptions. The authors noted that descriptions were no different on any measure including accuracy. It is suggested that less expertise in verbalizing faces rather than cars invokes a stronger shift in verbal and featural processing. This supports the concept of a transfer inappropriate retrieval framework and addresses some limitations of the effect. Wickham and Swift (2006) suggested that the verbal overshadowing effect is not seen in describing all faces, and one aspect that determines this is distinctiveness. Results showed that typical faces produce verbal overshadowing, while distinctive faces did not. In studies of eyewitness reports, variation in response criteria given by participants influenced the quality of the descriptions generated and accuracy on identification task, known as the retrieval-based effect. Face recognition was also impaired when subjects described a familiar face, such as a parent, or when describing a previously seen but novel face. Dodson, Johnson, and Schooler (1997) found that recognition was also impaired when participants were provided with a description of a previously seen face, and they were able to ignore provided versus self-generated descriptions more easily. This finding of verbal overshadowing suggested that eyewitness recognition is not only affected by their own descriptions, but of descriptions heard from others, such other eyewitness testimonies. == Voice recognition == The verbal overshadowing effect has also been found to affect voice identification. Research shows that describing a non-verbal stimuli leads to a decrease in recognition accuracy. In an unpublished study by Schooler, Fiore, Melcher, and Ambadar (1996), participants listened to a tape-recorded voice, after which they were asked either to verbally describe it or to not do so, and then asked to distinguish the voice from 3 similar distractor voices. The results showed that verbal overshadowing impaired accuracy of recognition based on gut feeling, suggesting an overall verbal overshadowing for voice recognition. Due to the forensic relevance of voices heard over the telephone and harassing phone calls that are often a problem for police, Perfect, Hunt, and Harris (2002) examined the influence of three factors on accuracy and confidence in voice recognition from a line-up. They expected to find an effect, because voice represents a class of stimuli that is difficult to describe verbally. This meets Schooler et al.'s (1997) modality mismatch criterion, meaning that describing the speakers age, gender, or accent is difficult, making voice recognition susceptible to the verbal overshadowing phenomenon. It was found that the method of memory encoding had no impact on performance, and that hearing a telephone voice reduced confidence but did not affect accuracy. They also found that providing a verbal description impaired accuracy but had no effect on confidence. The data showed an effect of verbal overshadowing in voice recognition and provided yet another disassociation between confidence and performance. Although there was a difference in confidence level, witnesses were able to identify voices over the telephone as accurately as voices heard direc

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  Automated Pain Recognition

  Automated Pain Recognition (APR) is a method for objectively measuring pain and at the same time represents an interdisciplinary research area that comprises elements of medicine, psychology, psychobiology, and computer science. The focus is on computer-aided objective recognition of pain, implemented on the basis of machine learning. Automated pain recognition allows for the valid, reliable detection and monitoring of pain in people who are unable to communicate verbally. The underlying machine learning processes are trained and validated in advance by means of unimodal or multimodal body signals. Signals used to detect pain may include facial expressions or gestures and may also be of a (psycho-)physiological or paralinguistic nature. To date, the focus has been on identifying pain intensity, but visionary efforts are also being made to recognize the quality, site, and temporal course of pain. However, the clinical implementation of this approach is a controversial topic in the field of pain research. Critics of automated pain recognition argue that pain diagnosis can only be performed subjectively by humans. == Background == Pain diagnosis under conditions where verbal reporting is restricted - such as in verbally and/or cognitively impaired people or in patients who are sedated or mechanically ventilated - is based on behavioral observations by trained professionals. However, all known observation procedures (e.g., Zurich Observation Pain Assessment (ZOPA)); Pain Assessment in Advanced Dementia Scale (PAINAD) require a great deal of specialist expertise. These procedures can be made more difficult by perception- and interpretation-related misjudgments on the part of the observer. With regard to the differences in design, methodology, evaluation sample, and conceptualization of the phenomenon of pain, it is difficult to compare the quality criteria of the various tools. Even if trained personnel could theoretically record pain intensity several times a day using observation instruments, it would not be possible to measure it every minute or second. In this respect, the goal of automated pain recognition is to use valid, robust pain response patterns that can be recorded multimodally for a temporally dynamic, high-resolution, automated pain intensity recognition system. == Procedure == For automated pain recognition, pain-relevant parameters are usually recorded using non-invasive sensor technology, which captures data on the (physical) responses of the person in pain. This can be achieved with camera technology that captures facial expressions, gestures, or posture, while audio sensors record paralinguistic features. (Psycho-)physiological information such as muscle tone and heart rate can be collected via biopotential sensors (electrodes). Pain recognition requires the extraction of meaningful characteristics or patterns from the data collected. This is achieved using machine learning techniques that are able to provide an assessment of the pain after training (learning), e.g., "no pain," "mild pain," or "severe pain." == Parameters == Although the phenomenon of pain comprises different components (sensory discriminative, affective (emotional), cognitive, vegetative, and (psycho-)motor), automated pain recognition currently relies on the measurable parameters of pain responses. These can be divided roughly into the two main categories of "physiological responses" and "behavioral responses". === Physiological responses === In humans, pain almost always initiates autonomic nervous processes that are reflected measurably in various physiological signals. ==== Physiological signals ==== Measurements can include electrodermal activity (EDA, also skin conductance), electromyography (EMG), electrocardiogram (ECG), blood volume pulse (BVP), electroencephalogram (EEG), respiration, and body temperature, which are regulatory mechanisms of the sympathetic and parasympathetic systems. Physiological signals are mainly recorded using special non-invasive surface electrodes (for EDA, EMG, ECG, and EEG), a blood volume pulse sensor (BVP), a respiratory belt (respiration), and a thermal sensor (body temperature). Endocrinological and immunological parameters can also be recorded, but this requires measures that are somewhat invasive (e.g., blood sampling). === Behavioral responses === Behavioral responses to pain fulfil two functions: protection of the body (e.g., through protective reflexes) and external communication of the pain (e.g., as a cry for help). The responses are particularly evident in facial expressions, gestures, and paralinguistic features. ==== Facial expressions ==== Behavioral signals captured comprise facial expression patterns (expressive behavior), which are measured with the aid of video signals. Facial expression recognition is based on the everyday clinical observation that pain often manifests itself in the patient's facial expressions but that this is not necessarily always the case, since facial expressions can be inhibited through self-control. Despite the possibility that facial expressions may be influenced consciously, facial expression behavior represents an essential source of information for pain diagnosis and is thus also a source of information for automatic pain recognition. One advantage of video-based facial expression recognition is the contact-free measurement of the face, provided that it can be captured on video, which is not possible in every position (e.g., lying face down) or may be limited by bandages covering the face. Facial expression analysis relies on rapid, spontaneous, and temporary changes in neuromuscular activity that lead to visually detectable changes in the face. ==== Gestures ==== Gestures are also captured predominantly using non-contact camera technology. Motor pain responses vary and are strongly dependent on the type and cause of the pain. They range from abrupt protective reflexes (e.g., spontaneous retraction of extremities or doubling up) to agitation (pathological restlessness) and avoidance behavior (hesitant, cautious movements). ==== Paralinguistic features of language ==== Among other things, pain leads to nonverbal linguistic behavior that manifests itself in sounds such as sighing, gasping, moaning, whining, etc. Paralinguistic features are usually recorded using highly sensitive microphones. == Algorithms == After the recording, pre-processing (e.g., filtering), and extraction of relevant features, an optional information fusion can be performed. During this process, modalities from different signal sources are merged to generate new or more precise knowledge. The pain is classified using machine learning processes. The method chosen has a significant influence on the recognition rate and depends greatly on the quality and granularity of the underlying data. Similar to the field of affective computing, the following classifiers are currently being used: Support Vector Machine (SVM): The goal of an SVM is to find a clearly defined optimal hyperplane with the greatest minimal distance to two (or more) classes to be separated. The hyperplane acts as a decision function for classifying an unknown pattern. Random Forest (RF): RF is based on the composition of random, uncorrelated decision trees. An unknown pattern is judged individually by each tree and assigned to a class. The final classification of the patterns by the RF is then based on a majority decision. k-Nearest Neighbors (k-NN): The k-NN algorithm classifies an unknown object using the class label that most commonly classifies the k neighbors closest to it. Its neighbors are determined using a selected similarity measure (e.g., Euclidean distance, Jaccard coefficient, etc.). Artificial neural networks (ANNs): ANNs are inspired by biological neural networks and model their organizational principles and processes in a very simplified manner. Class patterns are learned by adjusting the weights of the individual neuronal connections. == Databases == In order to classify pain in a valid manner, it is necessary to create representative, reliable, and valid pain databases that are available to the machine learner for training. An ideal database would be sufficiently large and would consist of natural (not experimental), high-quality pain responses. However, natural responses are difficult to record and can only be obtained to a limited extent; in most cases they are characterized by suboptimal quality. The databases currently available therefore contain experimental or quasi-experimental pain responses, and each database is based on a different pain model. The following list shows a selection of the most relevant pain databases (last updated: April 2020): UNBC-McMaster Shoulder Pain BioVid Heat Pain EmoPain SenseEmotion X-ITE Pain

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  Mean squared prediction error

  In statistics the mean squared prediction error (MSPE), also known as mean squared error of the predictions, of a smoothing, curve fitting, or regression procedure is the expected value of the squared prediction errors (PE), the square difference between the fitted values implied by the predictive function g ^ {\displaystyle {\widehat {g}}} and the values of the (unobservable) true value g. It is an inverse measure of the explanatory power of g ^ , {\displaystyle {\widehat {g}},} and can be used in the process of cross-validation of an estimated model. Knowledge of g would be required in order to calculate the MSPE exactly; in practice, MSPE is estimated. == Formulation == If the smoothing or fitting procedure has projection matrix (i.e., hat matrix) L, which maps the observed values vector y {\displaystyle y} to predicted values vector y ^ = L y , {\displaystyle {\hat {y}}=Ly,} then PE and MSPE are formulated as: P E i = g ( x i ) − g ^ ( x i ) , {\displaystyle \operatorname {PE_{i}} =g(x_{i})-{\widehat {g}}(x_{i}),} MSPE = E ⁡ [ PE i 2 ] = ∑ i = 1 n PE i 2 ⁡ / n . {\displaystyle \operatorname {MSPE} =\operatorname {E} \left[\operatorname {PE} _{i}^{2}\right]=\sum _{i=1}^{n}\operatorname {PE} _{i}^{2}/n.} The MSPE can be decomposed into two terms: the squared bias (mean error) of the fitted values and the variance of the fitted values: MSPE = ME 2 + VAR , {\displaystyle \operatorname {MSPE} =\operatorname {ME} ^{2}+\operatorname {VAR} ,} ME = E ⁡ [ g ^ ( x i ) − g ( x i ) ] {\displaystyle \operatorname {ME} =\operatorname {E} \left[{\widehat {g}}(x_{i})-g(x_{i})\right]} VAR = E ⁡ [ ( g ^ ( x i ) − E ⁡ [ g ( x i ) ] ) 2 ] . {\displaystyle \operatorname {VAR} =\operatorname {E} \left[\left({\widehat {g}}(x_{i})-\operatorname {E} \left[{g}(x_{i})\right]\right)^{2}\right].} The quantity SSPE=nMSPE is called sum squared prediction error. The root mean squared prediction error is the square root of MSPE: RMSPE=√MSPE. == Computation of MSPE over out-of-sample data == The mean squared prediction error can be computed exactly in two contexts. First, with a data sample of length n, the data analyst may run the regression over only q of the data points (with q < n), holding back the other n – q data points with the specific purpose of using them to compute the estimated model’s MSPE out of sample (i.e., not using data that were used in the model estimation process). Since the regression process is tailored to the q in-sample points, normally the in-sample MSPE will be smaller than the out-of-sample one computed over the n – q held-back points. If the increase in the MSPE out of sample compared to in sample is relatively slight, that results in the model being viewed favorably. And if two models are to be compared, the one with the lower MSPE over the n – q out-of-sample data points is viewed more favorably, regardless of the models’ relative in-sample performances. The out-of-sample MSPE in this context is exact for the out-of-sample data points that it was computed over, but is merely an estimate of the model’s MSPE for the mostly unobserved population from which the data were drawn. Second, as time goes on more data may become available to the data analyst, and then the MSPE can be computed over these new data. == Estimation of MSPE over the population == When the model has been estimated over all available data with none held back, the MSPE of the model over the entire population of mostly unobserved data can be estimated as follows. For the model y i = g ( x i ) + σ ε i {\displaystyle y_{i}=g(x_{i})+\sigma \varepsilon _{i}} where ε i ∼ N ( 0 , 1 ) {\displaystyle \varepsilon _{i}\sim {\mathcal {N}}(0,1)} , one may write n ⋅ MSPE ⁡ ( L ) = g T ( I − L ) T ( I − L ) g + σ 2 tr ⁡ [ L T L ] . {\displaystyle n\cdot \operatorname {MSPE} (L)=g^{\text{T}}(I-L)^{\text{T}}(I-L)g+\sigma ^{2}\operatorname {tr} \left[L^{\text{T}}L\right].} Using in-sample data values, the first term on the right side is equivalent to ∑ i = 1 n ( E ⁡ [ g ( x i ) − g ^ ( x i ) ] ) 2 = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 tr ⁡ [ ( I − L ) T ( I − L ) ] . {\displaystyle \sum _{i=1}^{n}\left(\operatorname {E} \left[g(x_{i})-{\widehat {g}}(x_{i})\right]\right)^{2}=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\operatorname {tr} \left[\left(I-L\right)^{T}\left(I-L\right)\right].} Thus, n ⋅ MSPE ⁡ ( L ) = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {MSPE} (L)=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\left(n-\operatorname {tr} \left[L\right]\right).} If σ 2 {\displaystyle \sigma ^{2}} is known or well-estimated by σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} , it becomes possible to estimate MSPE by n ⋅ M S P E ^ ⁡ ( L ) = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 − σ ^ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {\widehat {MSPE}} (L)=\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}-{\widehat {\sigma }}^{2}\left(n-\operatorname {tr} \left[L\right]\right).} Colin Mallows advocated this method in the construction of his model selection statistic Cp, which is a normalized version of the estimated MSPE: C p = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 σ ^ 2 − n + 2 p . {\displaystyle C_{p}={\frac {\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}}{{\widehat {\sigma }}^{2}}}-n+2p.} where p the number of estimated parameters p and σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} is computed from the version of the model that includes all possible regressors. That concludes this proof.

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  Expectation–maximization algorithm

  In statistics, an expectation–maximization (EM) algorithm is an iterative method to find (local) maximum likelihood or maximum a posteriori (MAP) estimates of parameters in statistical models, where the model depends on unobserved latent variables. The EM iteration alternates between performing an expectation (E) step, which creates a function for the expectation of the log-likelihood evaluated using the current estimate for the parameters, and a maximization (M) step, which computes parameters maximizing the expected log-likelihood found on the E step. These parameter-estimates are then used to determine the distribution of the latent variables in the next E step. It can be used, for example, to estimate a mixture of gaussians, or to solve the multiple linear regression problem. == History == The EM algorithm was explained and given its name in a classic 1977 paper by Arthur Dempster, Nan Laird, and Donald Rubin. They pointed out that the method had been "proposed many times in special circumstances" by earlier authors. One of the earliest is the gene-counting method for estimating allele frequencies by Cedric Smith. Another was proposed by H.O. Hartley in 1958, and Hartley and Hocking in 1977, from which many of the ideas in the Dempster–Laird–Rubin paper originated. Another one by S.K Ng, Thriyambakam Krishnan and G.J McLachlan in 1977. Hartley's ideas can be broadened to any grouped discrete distribution. A very detailed treatment of the EM method for exponential families was published by Rolf Sundberg in his thesis and several papers, following his collaboration with Per Martin-Löf and Anders Martin-Löf. The Dempster–Laird–Rubin paper in 1977 generalized the method and sketched a convergence analysis for a wider class of problems. The Dempster–Laird–Rubin paper established the EM method as an important tool of statistical analysis. See also Meng and van Dyk (1997). The convergence analysis of the Dempster–Laird–Rubin algorithm was flawed and a correct convergence analysis was published by C. F. Jeff Wu in 1983. Wu's proof established the EM method's convergence also outside of the exponential family, as claimed by Dempster–Laird–Rubin. == Introduction == The EM algorithm is used to find (local) maximum likelihood parameters of a statistical model in cases where the equations cannot be solved directly. Typically these models involve latent variables in addition to unknown parameters and known data observations. That is, either missing values exist among the data, or the model can be formulated more simply by assuming the existence of further unobserved data points. For example, a mixture model can be described more simply by assuming that each observed data point has a corresponding unobserved data point, or latent variable, specifying the mixture component to which each data point belongs. Finding a maximum likelihood solution typically requires taking the derivatives of the likelihood function with respect to all the unknown values, the parameters and the latent variables, and simultaneously solving the resulting equations. In statistical models with latent variables, this is usually impossible. Instead, the result is typically a set of interlocking equations in which the solution to the parameters requires the values of the latent variables and vice versa, but substituting one set of equations into the other produces an unsolvable equation. The EM algorithm proceeds from the observation that there is a way to solve these two sets of equations numerically. One can simply pick arbitrary values for one of the two sets of unknowns, use them to estimate the second set, then use these new values to find a better estimate of the first set, and then keep alternating between the two until the resulting values both converge to fixed points. It's not obvious that this will work, but it can be proven in this context. Additionally, it can be proven that the derivative of the likelihood is (arbitrarily close to) zero at that point, which in turn means that the point is either a local maximum or a saddle point. In general, multiple maxima may occur, with no guarantee that the global maximum will be found. Some likelihoods also have singularities in them, i.e., nonsensical maxima. For example, one of the solutions that may be found by EM in a mixture model involves setting one of the components to have zero variance and the mean parameter for the same component to be equal to one of the data points. == Description == === The symbols === Given the statistical model which generates a set X {\displaystyle \mathbf {X} } of observed data, a set of unobserved latent data or missing values Z {\displaystyle \mathbf {Z} } , and a vector of unknown parameters θ {\displaystyle {\boldsymbol {\theta }}} , along with a likelihood function L ( θ ; X , Z ) = p ( X , Z ∣ θ ) {\displaystyle L({\boldsymbol {\theta }};\mathbf {X} ,\mathbf {Z} )=p(\mathbf {X} ,\mathbf {Z} \mid {\boldsymbol {\theta }})} , the maximum likelihood estimate (MLE) of the unknown parameters is determined by maximizing the marginal likelihood of the observed data L ( θ ; X ) = p ( X ∣ θ ) = ∫ p ( X , Z ∣ θ ) d Z = ∫ p ( X ∣ Z , θ ) p ( Z ∣ θ ) d Z {\displaystyle {\begin{aligned}L({\boldsymbol {\theta }};\mathbf {X} )=p(\mathbf {X} \mid {\boldsymbol {\theta }})&=\int p(\mathbf {X} ,\mathbf {Z} \mid {\boldsymbol {\theta }})\,d\mathbf {Z} \\&=\int p(\mathbf {X} \mid \mathbf {Z} ,{\boldsymbol {\theta }})p(\mathbf {Z} \mid {\boldsymbol {\theta }})\,d\mathbf {Z} \end{aligned}}} However, this quantity is often intractable since Z {\displaystyle \mathbf {Z} } is unobserved and the distribution of Z {\displaystyle \mathbf {Z} } is unknown before attaining θ {\displaystyle {\boldsymbol {\theta }}} . === The EM algorithm === The EM algorithm seeks to find the maximum likelihood estimate of the marginal likelihood by iteratively applying these two steps: More succinctly, we can write it as one equation: θ ( t + 1 ) = arg ⁡ max θ ⁡ E Z ∼ p ( ⋅ | X , θ ( t ) ) ⁡ [ log ⁡ p ( X , Z | θ ) ] {\displaystyle {\boldsymbol {\theta }}^{(t+1)}=\mathop {\arg \max } _{\boldsymbol {\theta }}\operatorname {E} _{\mathbf {Z} \sim p(\cdot |\mathbf {X} ,{\boldsymbol {\theta }}^{(t)})}\left[\log p(\mathbf {X} ,\mathbf {Z} |{\boldsymbol {\theta }})\right]\,} === Interpretation of the variables === The typical models to which EM is applied use Z {\displaystyle \mathbf {Z} } as a latent variable indicating membership in one of a set of groups: The observed data points X {\displaystyle \mathbf {X} } may be discrete (taking values in a finite or countably infinite set) or continuous (taking values in an uncountably infinite set). Associated with each data point may be a vector of observations. The missing values (aka latent variables) Z {\displaystyle \mathbf {Z} } are discrete, drawn from a fixed number of values, and with one latent variable per observed unit. The parameters are continuous, and are of two kinds: Parameters that are associated with all data points, and those associated with a specific value of a latent variable (i.e., associated with all data points whose corresponding latent variable has that value). However, it is possible to apply EM to other sorts of models. The motivation is as follows. If the value of the parameters θ {\displaystyle {\boldsymbol {\theta }}} is known, usually the value of the latent variables Z {\displaystyle \mathbf {Z} } can be found by maximizing the log-likelihood over all possible values of Z {\displaystyle \mathbf {Z} } , either simply by iterating over Z {\displaystyle \mathbf {Z} } or through an algorithm such as the Viterbi algorithm for hidden Markov models. Conversely, if we know the value of the latent variables Z {\displaystyle \mathbf {Z} } , we can find an estimate of the parameters θ {\displaystyle {\boldsymbol {\theta }}} fairly easily, typically by simply grouping the observed data points according to the value of the associated latent variable and averaging the values, or some function of the values, of the points in each group. This suggests an iterative algorithm, in the case where both θ {\displaystyle {\boldsymbol {\theta }}} and Z {\displaystyle \mathbf {Z} } are unknown: First, initialize the parameters θ {\displaystyle {\boldsymbol {\theta }}} to some random values. Compute the probability of each possible value of ⁠ Z {\displaystyle \mathbf {Z} } ⁠, given ⁠ θ {\displaystyle {\boldsymbol {\theta }}} ⁠. Then, use the just-computed values of Z {\displaystyle \mathbf {Z} } to compute a better estimate for the parameters ⁠ θ {\displaystyle {\boldsymbol {\theta }}} ⁠. Iterate steps 2 and 3 until convergence. The algorithm as just described monotonically approaches a local minimum of the cost function. == Properties == Although an EM iteration does increase the observed data (i.e., marginal) likelihood function, no guarantee exists that the sequence converges to a maximum likelihood estimator. For multimodal distributions, this means that an EM algorithm may co

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  Adobe GoLive

  Adobe GoLive was a WYSIWYG HTML editor and web site management application from Adobe Systems. It replaced Adobe PageMill as Adobe's primary HTML editor and was itself discontinued in favor of Dreamweaver. The last version of GoLive that Adobe released was GoLive 9. == History == GoLive originated as the flagship product of a company named GoNet Communication, Inc. then based in Menlo Park, California, and the development company GoNet Communications GmbH in Hamburg, Germany, in 1996. Later GoNet changed its name to GoLive Systems, Inc, and the name of its product to GoLive CyberStudio. Adobe acquired GoLive in 1999 and re-branded the GoLive CyberStudio product to what became Adobe GoLive. Adobe took over the Hamburg office as an Adobe development site to continue to develop the product. At the time of the acquisition, CyberStudio was a Macintosh-only application. In the spring of 1999 Adobe released Adobe GoLive for both Macintosh and Microsoft Windows. The first versions of Dreamweaver and CyberStudio were released in a similar timeframe. However, Dreamweaver eventually became the dominant WYSIWYG HTML editor in market share. After the Adobe acquisition of Macromedia (the company that had owned Dreamweaver), GoLive was progressively re-targeted toward Adobe's traditional design market, and the product became better integrated with Adobe's existing suite of design-oriented software products and less focused on the professional web development market. The Adobe CS2 Premium suite contained GoLive CS2. With the release of Creative Suite 3, Adobe integrated Dreamweaver as a replacement for GoLive and released GoLive 9 as a standalone product. In April 2008, Adobe announced that sales and development of GoLive would cease in favor of Dreamweaver. == General description and distinctive aspects == GoLive incorporated a largely modeless workflow that relied heavily on drag-and-drop. Most user interaction was done via a contextual inspector rather than the modal workflow found in Dreamweaver. Among its features were a separate editor for tables that supported nesting, and a two-dimensional panel for applying CSS styles to elements. GoLive supported drag-and-drop of native Adobe Photoshop and Adobe Illustrator files via what the company called "Smart Objects", which then automatically guided the user through saving those files in web-supported formats. Updates to the original Photoshop or Illustrator assets were automatically tracked by GoLive. It also implemented a tool called "Components" which allowed updates to interface elements throughout a site to be updated globally by changing one single file. As a website management tool, GoLive allowed users to transfer and publish content directly from within the application, and allowed individual files to be excluded from uploading. == Features == One of the new features of GoLive version 5 was Dynamic Link, which was a method of creating dynamic, database-driven web content without the need to know a server-side language and with full WYSIWYG support in the GoLive user interface. GoLive had a powerful set of extensibility API which could be used to add additional functionality to the product. The GoLive SDK provided interfaces which allowed developers to use a combination of XML, JavaScript and C/C++ to create plugins for the product. The extensibility API allowed developers access to custom drawing and event handling using JavaScript, as well as a full JavaScript debugger and command line interpreter. This allowed intermediate-level developers using interpreted JavaScript to create sophisticated user interfaces. == Language and framework structure == Adobe GoLive is coded in the C++ programming language. It uses a custom C++ framework called SCL (Simple Class Library) which was initially built from scratch by the engineers at GoLive Systems Inc. The SCL framework was also used in the short-lived Adobe Atmosphere 3D software. == Release history == As the final version, GoLive 9 was discontinued in April 2008.

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  Targeted maximum likelihood estimation

  Targeted Maximum Likelihood Estimation (TMLE) (also more accurately referred to as Targeted Minimum Loss-Based Estimation) is a general statistical estimation framework for causal inference and semiparametric models. TMLE combines ideas from maximum likelihood estimation, semiparametric efficiency theory, and machine learning. It was introduced by Mark J. van der Laan and colleagues in the mid-2000s as a method that yields asymptotically efficient plug-in estimators while allowing the use of flexible, data-adaptive algorithms such as ensemble machine learning for nuisance parameter estimation. TMLE is used in epidemiology, biostatistics, and the social sciences to estimate causal effects in observational and experimental studies. Applications of TMLE include Longitudinal TMLE (LTMLE) for time-varying treatments and confounders. Variations in how the targeting step in TMLE is carried out have resulted in various versions of TMLE such as Collaborative TMLE (CTMLE) and Adaptive TMLE for improved finite-sample performance and automated variable selection. == History == The TMLE framework was first described by van der Laan and Rubin (2006) as a general approach for the construction of efficient plug-in estimators of smooth features of the data density. It was demonstrated in the context of causal inference and missing data problems. It was developed to address limitations of traditional doubly robust methods, such as Augmented Inverse Probability Weighting (AIPW), by respecting the plug-in principle in the sense that it respects that the target parameter is a function of the data density that is an element of the statistical model. TMLE estimates the data density or relevant parts of it with machine learning and targets these machine learning fits before it is plugged in the target parameter mapping. In this manner, a TMLE always respects global knowledge and satisfies known bounds such as that the target parameter is a probability . Since its introduction, TMLE has been developed in a series of theoretical and applied papers, culminating in book-length treatments of the method and its applications to survival analysis, adaptive designs, and longitudinal data. == Methodology == At its core, TMLE is a two-step estimation procedure: Initial estimation: Machine learning methods (such as the Super Learner ensemble) are used to obtain flexible estimates of nuisance parameters, such as outcome regressions and propensity scores. Targeting step: The initial estimate is updated by solving a score equation (the efficient influence function) so that the final estimator is consistent, asymptotically normal, and efficient under mild regularity conditions. The targeted machine learning fit is then mapped into the corresponding estimator of the target parameter by simply plugging it in the target parameter mapping. This approach balances the bias–variance trade-off by combining data-adaptive estimation with semiparametric efficiency theory. TMLE is doubly robust, meaning it remains consistent if either the outcome model or the treatment model is consistently estimated. === Formula === Here we explain the TMLE of the average treatment effect of a binary treatment on an outcome adjusting for baseline covariates. Consider i.i.d. observations O i = ( W i , A i , Y i ) {\displaystyle O_{i}=(W_{i},A_{i},Y_{i})} from a distribution P 0 {\displaystyle P_{0}} , where W {\displaystyle W} are baseline covariates, A {\displaystyle A} is a binary treatment, and Y {\displaystyle Y} is an outcome. Let Q ¯ ( a , w ) = E [ Y ∣ A = a , W = w ] {\displaystyle {\bar {Q}}(a,w)=\mathbb {E} [Y\mid A=a,W=w]} represent the outcome model and g ( a ∣ w ) = P ( A = a ∣ W = w ) {\displaystyle g(a\mid w)=P(A=a\mid W=w)} represent the propensity score. The average treatment effect (ATE) is given by ψ 0 = E { Q ¯ ( 1 , W ) − Q ¯ ( 0 , W ) } . {\displaystyle \psi _{0}=\mathbb {E} \{{\bar {Q}}(1,W)-{\bar {Q}}(0,W)\}.} A basic TMLE for the ATE proceeds as follows: Step 1: Estimate initial models. Obtain estimates Q ¯ ^ ( a , w ) {\displaystyle {\hat {\bar {Q}}}(a,w)} and g ^ ( a ∣ w ) {\displaystyle {\hat {g}}(a\mid w)} , often using flexible methods such as Super Learner. Step 2: Compute the clever covariate. Define: H ( A , W ) = A g ^ ( 1 ∣ W ) − 1 − A g ^ ( 0 ∣ W ) . {\displaystyle H(A,W)={\frac {A}{{\hat {g}}(1\mid W)}}-{\frac {1-A}{{\hat {g}}(0\mid W)}}.} Step 3: Estimate the fluctuation parameter. Fit a logistic regression of Y {\displaystyle Y} on H ( A , W ) {\displaystyle H(A,W)} with logit ⁡ ( Q ¯ ^ ( A , W ) ) {\displaystyle \operatorname {logit} ({\hat {\bar {Q}}}(A,W))} as offset. This yields ε ^ {\displaystyle {\hat {\varepsilon }}} , the MLE that solves the score equation: 1 n ∑ i = 1 n H ( A i , W i ) { Y i − Q ¯ ^ ε ( A i , W i ) } = 0. {\displaystyle {\frac {1}{n}}\sum _{i=1}^{n}H(A_{i},W_{i}){\big \{}Y_{i}-{\hat {\bar {Q}}}^{\varepsilon }(A_{i},W_{i}){\big \}}=0.} Step 4: Update the initial estimate. Apply the "blip" to obtain the targeted estimate: Q ¯ ^ ∗ ( A , W ) = expit ⁡ ( logit ⁡ ( Q ¯ ^ ( A , W ) ) + ε ^ H ( A , W ) ) . {\displaystyle {\hat {\bar {Q}}}^{}(A,W)=\operatorname {expit} {\Big (}\operatorname {logit} {\big (}{\hat {\bar {Q}}}(A,W){\big )}+{\hat {\varepsilon }}\,H(A,W){\Big )}.} Step 5: Compute the TMLE. The ATE estimate is: ψ ^ TMLE = 1 n ∑ i = 1 n [ Q ¯ ^ ∗ ( 1 , W i ) − Q ¯ ^ ∗ ( 0 , W i ) ] . {\displaystyle {\hat {\psi }}_{\text{TMLE}}={\frac {1}{n}}\sum _{i=1}^{n}{\big [}{\hat {\bar {Q}}}^{}(1,W_{i})-{\hat {\bar {Q}}}^{}(0,W_{i}){\big ]}.} Inference. The efficient influence function (EIF) for the ATE is: D ∗ ( O ) = H ( A , W ) { Y − Q ¯ ∗ ( A , W ) } + Q ¯ ∗ ( 1 , W ) − Q ¯ ∗ ( 0 , W ) − ψ . {\displaystyle D^{}(O)=H(A,W)\{Y-{\bar {Q}}^{}(A,W)\}+{\bar {Q}}^{}(1,W)-{\bar {Q}}^{}(0,W)-\psi .} The variance is estimated by σ ^ 2 = n − 1 ∑ i = 1 n ( D ∗ ( O i ) ) 2 {\displaystyle {\hat {\sigma }}^{2}=n^{-1}\sum _{i=1}^{n}{\big (}D^{}(O_{i}){\big )}^{2}} , yielding Wald-type confidence intervals ψ ^ TMLE ± z 1 − α / 2 σ ^ / n {\displaystyle {\hat {\psi }}_{\text{TMLE}}\pm z_{1-\alpha /2}\,{\hat {\sigma }}/{\sqrt {n}}} . Remark. For continuous outcomes, a linear fluctuation Q ¯ ^ ∗ = Q ¯ ^ + ε ^ H {\displaystyle {\hat {\bar {Q}}}^{}={\hat {\bar {Q}}}+{\hat {\varepsilon }}\,H} may be used instead. For bounded continuous outcomes, the logistic fluctuation (after rescaling Y {\displaystyle Y} to [ 0 , 1 ] {\displaystyle [0,1]} ) is often preferred for improved finite-sample performance. == Applications == TMLE has been applied in: Epidemiology: Estimating causal effects of exposures and interventions in observational cohort studies. Clinical trials and real-world evidence: The Targeted Learning roadmap provides a structured framework for generating and validating real-world evidence (RWE), bridging randomized trials and observational data using TMLE and related estimation techniques. This approach enables transparency, sensitivity analysis, and stronger causal inference for regulatory and clinical trial contexts. High-dimensional settings: Integration with ensemble methods for causal effect estimation. TMLE has been successfully applied in pharmacoepidemiology where a large number of covariates are automatically selected to adjust for confounding. In a study of post–myocardial infarction statin use and 1-year mortality, TMLE demonstrated robust performance relative to inverse probability weighting in scenarios with hundreds of potential confounders. == Derivatives and extensions == Longitudinal TMLE (LTMLE): A methodological extension of TMLE for longitudinal data with time-varying treatments, confounders, and censoring. It allows the estimation of dynamic treatment regimes and intervention-specific causal effects over time. This framework was originally introduced by van der Laan & Gruber (2012). Collaborative TMLE (CTMLE): Enhances finite-sample performance and variable selection by collaboratively fitting the treatment mechanism in conjunction with the target parameter. == Software == Several R packages implement TMLE and related methods: tmle: Functions for binary, categorical, and continuous outcomes. ltmle: Implementation for longitudinal data with time-varying treatments and outcomes. ctmle: Algorithms for collaborative TMLE and adaptive variable selection. SuperLearner: A theoretically grounded, cross-validated ensemble learning method that combines predictions from multiple algorithms to minimize predictive risk. Widely used in TMLE for estimating nuisance parameters. The original implementation is available as the R package SuperLearner. Recent machine learning platforms like H2O AutoML implement similar ensemble strategies, combining diverse learners in parallel and leveraging stacking and blending techniques, effectively functioning as a large-scale Super Learner.

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  Targeted maximum likelihood estimation

  Targeted Maximum Likelihood Estimation (TMLE) (also more accurately referred to as Targeted Minimum Loss-Based Estimation) is a general statistical estimation framework for causal inference and semiparametric models. TMLE combines ideas from maximum likelihood estimation, semiparametric efficiency theory, and machine learning. It was introduced by Mark J. van der Laan and colleagues in the mid-2000s as a method that yields asymptotically efficient plug-in estimators while allowing the use of flexible, data-adaptive algorithms such as ensemble machine learning for nuisance parameter estimation. TMLE is used in epidemiology, biostatistics, and the social sciences to estimate causal effects in observational and experimental studies. Applications of TMLE include Longitudinal TMLE (LTMLE) for time-varying treatments and confounders. Variations in how the targeting step in TMLE is carried out have resulted in various versions of TMLE such as Collaborative TMLE (CTMLE) and Adaptive TMLE for improved finite-sample performance and automated variable selection. == History == The TMLE framework was first described by van der Laan and Rubin (2006) as a general approach for the construction of efficient plug-in estimators of smooth features of the data density. It was demonstrated in the context of causal inference and missing data problems. It was developed to address limitations of traditional doubly robust methods, such as Augmented Inverse Probability Weighting (AIPW), by respecting the plug-in principle in the sense that it respects that the target parameter is a function of the data density that is an element of the statistical model. TMLE estimates the data density or relevant parts of it with machine learning and targets these machine learning fits before it is plugged in the target parameter mapping. In this manner, a TMLE always respects global knowledge and satisfies known bounds such as that the target parameter is a probability . Since its introduction, TMLE has been developed in a series of theoretical and applied papers, culminating in book-length treatments of the method and its applications to survival analysis, adaptive designs, and longitudinal data. == Methodology == At its core, TMLE is a two-step estimation procedure: Initial estimation: Machine learning methods (such as the Super Learner ensemble) are used to obtain flexible estimates of nuisance parameters, such as outcome regressions and propensity scores. Targeting step: The initial estimate is updated by solving a score equation (the efficient influence function) so that the final estimator is consistent, asymptotically normal, and efficient under mild regularity conditions. The targeted machine learning fit is then mapped into the corresponding estimator of the target parameter by simply plugging it in the target parameter mapping. This approach balances the bias–variance trade-off by combining data-adaptive estimation with semiparametric efficiency theory. TMLE is doubly robust, meaning it remains consistent if either the outcome model or the treatment model is consistently estimated. === Formula === Here we explain the TMLE of the average treatment effect of a binary treatment on an outcome adjusting for baseline covariates. Consider i.i.d. observations O i = ( W i , A i , Y i ) {\displaystyle O_{i}=(W_{i},A_{i},Y_{i})} from a distribution P 0 {\displaystyle P_{0}} , where W {\displaystyle W} are baseline covariates, A {\displaystyle A} is a binary treatment, and Y {\displaystyle Y} is an outcome. Let Q ¯ ( a , w ) = E [ Y ∣ A = a , W = w ] {\displaystyle {\bar {Q}}(a,w)=\mathbb {E} [Y\mid A=a,W=w]} represent the outcome model and g ( a ∣ w ) = P ( A = a ∣ W = w ) {\displaystyle g(a\mid w)=P(A=a\mid W=w)} represent the propensity score. The average treatment effect (ATE) is given by ψ 0 = E { Q ¯ ( 1 , W ) − Q ¯ ( 0 , W ) } . {\displaystyle \psi _{0}=\mathbb {E} \{{\bar {Q}}(1,W)-{\bar {Q}}(0,W)\}.} A basic TMLE for the ATE proceeds as follows: Step 1: Estimate initial models. Obtain estimates Q ¯ ^ ( a , w ) {\displaystyle {\hat {\bar {Q}}}(a,w)} and g ^ ( a ∣ w ) {\displaystyle {\hat {g}}(a\mid w)} , often using flexible methods such as Super Learner. Step 2: Compute the clever covariate. Define: H ( A , W ) = A g ^ ( 1 ∣ W ) − 1 − A g ^ ( 0 ∣ W ) . {\displaystyle H(A,W)={\frac {A}{{\hat {g}}(1\mid W)}}-{\frac {1-A}{{\hat {g}}(0\mid W)}}.} Step 3: Estimate the fluctuation parameter. Fit a logistic regression of Y {\displaystyle Y} on H ( A , W ) {\displaystyle H(A,W)} with logit ⁡ ( Q ¯ ^ ( A , W ) ) {\displaystyle \operatorname {logit} ({\hat {\bar {Q}}}(A,W))} as offset. This yields ε ^ {\displaystyle {\hat {\varepsilon }}} , the MLE that solves the score equation: 1 n ∑ i = 1 n H ( A i , W i ) { Y i − Q ¯ ^ ε ( A i , W i ) } = 0. {\displaystyle {\frac {1}{n}}\sum _{i=1}^{n}H(A_{i},W_{i}){\big \{}Y_{i}-{\hat {\bar {Q}}}^{\varepsilon }(A_{i},W_{i}){\big \}}=0.} Step 4: Update the initial estimate. Apply the "blip" to obtain the targeted estimate: Q ¯ ^ ∗ ( A , W ) = expit ⁡ ( logit ⁡ ( Q ¯ ^ ( A , W ) ) + ε ^ H ( A , W ) ) . {\displaystyle {\hat {\bar {Q}}}^{}(A,W)=\operatorname {expit} {\Big (}\operatorname {logit} {\big (}{\hat {\bar {Q}}}(A,W){\big )}+{\hat {\varepsilon }}\,H(A,W){\Big )}.} Step 5: Compute the TMLE. The ATE estimate is: ψ ^ TMLE = 1 n ∑ i = 1 n [ Q ¯ ^ ∗ ( 1 , W i ) − Q ¯ ^ ∗ ( 0 , W i ) ] . {\displaystyle {\hat {\psi }}_{\text{TMLE}}={\frac {1}{n}}\sum _{i=1}^{n}{\big [}{\hat {\bar {Q}}}^{}(1,W_{i})-{\hat {\bar {Q}}}^{}(0,W_{i}){\big ]}.} Inference. The efficient influence function (EIF) for the ATE is: D ∗ ( O ) = H ( A , W ) { Y − Q ¯ ∗ ( A , W ) } + Q ¯ ∗ ( 1 , W ) − Q ¯ ∗ ( 0 , W ) − ψ . {\displaystyle D^{}(O)=H(A,W)\{Y-{\bar {Q}}^{}(A,W)\}+{\bar {Q}}^{}(1,W)-{\bar {Q}}^{}(0,W)-\psi .} The variance is estimated by σ ^ 2 = n − 1 ∑ i = 1 n ( D ∗ ( O i ) ) 2 {\displaystyle {\hat {\sigma }}^{2}=n^{-1}\sum _{i=1}^{n}{\big (}D^{}(O_{i}){\big )}^{2}} , yielding Wald-type confidence intervals ψ ^ TMLE ± z 1 − α / 2 σ ^ / n {\displaystyle {\hat {\psi }}_{\text{TMLE}}\pm z_{1-\alpha /2}\,{\hat {\sigma }}/{\sqrt {n}}} . Remark. For continuous outcomes, a linear fluctuation Q ¯ ^ ∗ = Q ¯ ^ + ε ^ H {\displaystyle {\hat {\bar {Q}}}^{}={\hat {\bar {Q}}}+{\hat {\varepsilon }}\,H} may be used instead. For bounded continuous outcomes, the logistic fluctuation (after rescaling Y {\displaystyle Y} to [ 0 , 1 ] {\displaystyle [0,1]} ) is often preferred for improved finite-sample performance. == Applications == TMLE has been applied in: Epidemiology: Estimating causal effects of exposures and interventions in observational cohort studies. Clinical trials and real-world evidence: The Targeted Learning roadmap provides a structured framework for generating and validating real-world evidence (RWE), bridging randomized trials and observational data using TMLE and related estimation techniques. This approach enables transparency, sensitivity analysis, and stronger causal inference for regulatory and clinical trial contexts. High-dimensional settings: Integration with ensemble methods for causal effect estimation. TMLE has been successfully applied in pharmacoepidemiology where a large number of covariates are automatically selected to adjust for confounding. In a study of post–myocardial infarction statin use and 1-year mortality, TMLE demonstrated robust performance relative to inverse probability weighting in scenarios with hundreds of potential confounders. == Derivatives and extensions == Longitudinal TMLE (LTMLE): A methodological extension of TMLE for longitudinal data with time-varying treatments, confounders, and censoring. It allows the estimation of dynamic treatment regimes and intervention-specific causal effects over time. This framework was originally introduced by van der Laan & Gruber (2012). Collaborative TMLE (CTMLE): Enhances finite-sample performance and variable selection by collaboratively fitting the treatment mechanism in conjunction with the target parameter. == Software == Several R packages implement TMLE and related methods: tmle: Functions for binary, categorical, and continuous outcomes. ltmle: Implementation for longitudinal data with time-varying treatments and outcomes. ctmle: Algorithms for collaborative TMLE and adaptive variable selection. SuperLearner: A theoretically grounded, cross-validated ensemble learning method that combines predictions from multiple algorithms to minimize predictive risk. Widely used in TMLE for estimating nuisance parameters. The original implementation is available as the R package SuperLearner. Recent machine learning platforms like H2O AutoML implement similar ensemble strategies, combining diverse learners in parallel and leveraging stacking and blending techniques, effectively functioning as a large-scale Super Learner.

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