State–action–reward–state–action (SARSA) is an algorithm for learning a Markov decision process policy, used in the reinforcement learning area of machine learning. It was proposed by Rummery and Niranjan in a technical note with the name "Modified Connectionist Q-Learning" (MCQ-L). The alternative name SARSA, proposed by Rich Sutton, was only mentioned as a footnote. This name reflects the fact that the main function for updating the Q-value depends on the current state of the agent "S1", the action the agent chooses "A1", the reward "R2" the agent gets for choosing this action, the state "S2" that the agent enters after taking that action, and finally the next action "A2" the agent chooses in its new state. The acronym for the quintuple (St, At, Rt+1, St+1, At+1) is SARSA. Some authors use a slightly different convention and write the quintuple (St, At, Rt, St+1, At+1), depending on which time step the reward is formally assigned. The rest of the article uses the former convention. == Algorithm == Q new ( S t , A t ) ← ( 1 − α ) Q ( S t , A t ) + α [ R t + 1 + γ Q ( S t + 1 , A t + 1 ) ] {\displaystyle Q^{\textrm {new}}(S_{t},A_{t})\leftarrow (1-\alpha )Q(S_{t},A_{t})+\alpha \,[R_{t+1}+\gamma \,Q(S_{t+1},A_{t+1})]} A SARSA agent interacts with the environment and updates the policy based on actions taken, hence this is known as an on-policy learning algorithm. The Q value for a state-action is updated by an error, adjusted by the learning rate α. Q values represent the possible reward received in the next time step for taking action a in state s, plus the discounted future reward received from the next state-action observation. Watkin's Q-learning updates an estimate of the optimal state-action value function Q ∗ {\displaystyle Q^{}} based on the maximum reward of available actions. While SARSA learns the Q values associated with taking the policy it follows itself, Watkin's Q-learning learns the Q values associated with taking the optimal policy while following an exploration/exploitation policy. Some optimizations of Watkin's Q-learning may be applied to SARSA. == Hyperparameters == === Learning rate (alpha) === The learning rate determines to what extent newly acquired information overrides old information. A factor of 0 will make the agent not learn anything, while a factor of 1 would make the agent consider only the most recent information. === Discount factor (gamma) === The discount factor determines the importance of future rewards. A discount factor of 0 makes the agent "opportunistic", or "myopic", e.g., by only considering current rewards, while a factor approaching 1 will make it strive for a long-term high reward. If the discount factor meets or exceeds 1, the Q {\displaystyle Q} values may diverge. === Initial conditions (Q(S0, A0)) === Since SARSA is an iterative algorithm, it implicitly assumes an initial condition before the first update occurs. A high (infinite) initial value, also known as "optimistic initial conditions", can encourage exploration: no matter what action takes place, the update rule causes it to have higher values than the other alternative, thus increasing their choice probability. In 2013 it was suggested that the first reward r {\displaystyle r} could be used to reset the initial conditions. According to this idea, the first time an action is taken the reward is used to set the value of Q {\displaystyle Q} . This allows immediate learning in case of fixed deterministic rewards. This resetting-of-initial-conditions (RIC) approach seems to be consistent with human behavior in repeated binary choice experiments.
Oracle Cloud
Oracle Cloud is a cloud computing service offered by Oracle Corporation providing servers, storage, network, applications and services through a global network of Oracle Corporation managed data centers. The company allows these services to be provisioned on demand over the Internet. Oracle Cloud provides infrastructure as a service (IaaS), platform as a service (PaaS), software as a service (SaaS), and data as a service (DaaS). These services are used to build, deploy, integrate, and extend applications in the cloud. This platform supports numerous open standards (SQL, HTML5, REST, etc.), open-source applications (Kubernetes, Spark, Hadoop, Kafka, MySQL, Terraform, etc.), and a variety of programming languages, databases, tools, and frameworks including Oracle-specific, open source, and third-party software and systems. == Services == === Infrastructure as a Service (IaaS) and Platform as a Service (PaaS) === Oracle's cloud infrastructure was made generally available (GA) on October 20, 2016 under the name "Oracle Bare Metal Cloud Services". Oracle Bare Metal Cloud Services was rebranded as Oracle Cloud Infrastructure in 2018 and dubbed Oracle's "Generation 2 Cloud" at Oracle OpenWorld 2018. Oracle Cloud Infrastructure offerings include the following services: Compute: The company provides Virtual Machine Instances to provide different shapes (VM sizes) catering to different types of workloads and performance characteristics. They also provide on-demand Bare metal servers and Bare metal GPU servers, without a hypervisor. In 2016, Oracle Cloud Infrastructure launched with bare metal instances with Intel processors. These first bare metal instances offered were powered by Intel servers. In 2018, Oracle Cloud added bare metal instances powered by AMD processors, followed by Ampere Cloud-native processors in 2021. In 2021, Oracle also released its first VM-based compute instances based on Arm processors. Storage: The platform provides block volumes, file storage, object storage, and archive storage for database, analytics, content, and other applications across common protocols and APIs. Networking: This cloud platform provides network with fully configurable IP addresses, subnets, routing, and firewalls to support new or existing private networks with end-to-end security. Governance: For auditing, identity and access management, the platform has data integrity checks, traceability, and access management features. Database Management / Data Management: Oracle offers a data management platform for database workloads as well as hyper-scale big data and streaming workloads including OLTP, data warehousing, Spark, machine learning, text search, image analytics, data catalog, and deep learning. The platform allows Oracle, MySQL, and NoSQL databases to be deployed on demand as managed cloud services. Oracle Databases uniquely offer the Oracle Autonomous Database (optimized for data warehouse, transaction processing, or JSON), the Exadata shape, as well as Real Application Clusters (RAC). Load Balancing: The cloud platform offers load balancing capability to automatically route traffic across fault domains and availability domains for high availability and fault-tolerance for hosted applications. Edge Services: These services can monitor the path between users and resources and adapt to changes and outages. They include Domain Name System (DNS) services from Oracle's acquisition of Dyn. FastConnect: The cloud platform provides private connectivity across on-premises and cloud networks through providers like Equinix, AT&T, and Colt. Application Development: For application development, the company's cloud offers an open, standards-based application development platform to build, deploy, and manage API-first, mobile-first cloud applications. This platform supports container-native, cloud-native, and low code development. This platform also provides a DevOps platform for CI/CD, diagnostics for Java applications, and integration with SaaS and on-prem applications. Services include Java, mobile, digital assistants (evolution from chatbots), messaging, application container cloud, developer cloud, visual builder, API catalog, AI platform, DataScience.com (Oracle acquired) and blockchain. Integration: This is a platform offering with adapters to integrate on-premise and cloud applications. Capabilities include data integration and replication, API management, integration analytics, along with data migration and integration. They offer services such as data integration platform cloud, data integrator cloud service, GoldenGate cloud service, integration cloud, process cloud service, API platform cloud service, apiary cloud service, and SOA cloud service. Business Analytics: The company provides this business analytics platform which can analyze and generate insights from data across various applications, data warehouses, and data lakes. The services offered include analytics cloud, business intelligence, big data discovery, big data preparation, data visualization, and essbase. Security: The Oracle Cloud Platform provides identity and security applications for providing secure access and monitoring of hybrid cloud environment and addressing IT governance and compliance requirements. This platform delivers an identity SOC (Security Operations Center) through a combined offering of SIEM, UEBA, CASB, and IDaaS. The services offered include Identity Cloud Service and CASB Cloud Service. Management: The platform provides an integrated monitoring, management, and analytics platform. This platform also uses machine learning and big data on the operational data set. The platform is used to improve IT stability, prevent application outages, improve DevOps, and harden security. Services offered include Application Performance Monitoring, Infrastructure Monitoring, Log Analytics, Orchestration, IT Analytics, Configuration and Compliance, Security Monitoring, and Analytics. Content and Experience: This is a platform for content, website, and workflow management. This service is used to provide content collaboration and web presence. This tool comes integrated with Oracle on-premise and SaaS services. The services offered are Content and Experience Cloud, WebCenter Portal Cloud, and DIVA Cloud. In 2016, Oracle acquired Dyn, an internet infrastructure company. On May 16, 2018 Oracle announced that it had acquired DataScience.com, a privately held cloud workspace platform for data science projects and workloads. In April 2020, Oracle became the cloud infrastructure provider for Zoom, an online and video meeting platform. The same month, Nissan announced its migration to Oracle Cloud for its high-performance computing (HPC) workloads used for simulating the structural impacts of a car design. Xerox announced a partnership with Oracle Cloud in 2021, where Xerox will use Oracle's cloud-computing capabilities within its business incubator. === Software as a Service (SaaS) === Oracle provides SaaS applications also known as Oracle Cloud Applications. These applications are offered across a variety of products, industrial sectors with various deployment options to adhere to compliance standards. The below list mentions Oracle Cloud Applications provided by Oracle Corporation. Customer Experience (CX) Human Capital Management (HCM) Enterprise Resource Planning (ERP) Supply Chain Management (SCM) Enterprise Performance Management (EPM) Internet of Things Applications (IoT) SaaS Analytics Data Industry Solutions (Communications, Financial Services, Consumer Goods, High Tech and Manufacturing, Higher Education, Hospitality, Utilities) Deployment (adhering to standards for sectors such as Financial Services, Retail Services, Public Sector, Defense) Block-Chain Cloud Service (in partnership with SAP, IBM and Microsoft) Blockchain Applications On July 28, 2016 Oracle bought NetSuite, the very first cloud company, for $9.3 billion. === Data as a Service (DaaS) === This platform is known as the Oracle Data Cloud. This platform aggregates and analyzes consumer data powered by Oracle ID Graph across channels and devices to create cross-channel consumer understanding. == Deployment models == Oracle Cloud is available in 44 regions as of July 2023, including North America, South America, UK, European Union, Middle East, Africa, India, Australia, Korea, and Japan. Oracle Cloud is available as a public cloud (Oracle-managed regions); to selected government agencies as an Oracle-managed government cloud in the United States (with FedRAMP High and DISA SRG IL5 compliance) and United Kingdom; and as a "private cloud" or "hybrid cloud" as an Oracle-managed database-only service or full-service dedicated region - what Oracle calls "Cloud at Customer". == Architecture == Oracle's public and government cloud is offered through a global network of Oracle-managed data centers, connected by an Oracle-managed backbone network. Oracle's Exadata Cloud at Customer leverages this network for contr
Qstack
Qstack is a cloud management platform developed by GreenQloud, a cloud computing software company founded in Reykjavik, Iceland in February 2010. Qstack enables its users to manage multiple clouds and hybrid deployments through a single self-service portal. Qstack is in continuous development, incorporating developments within infrastructure, cloud, and application management solutions. The next release of Qstack is slated for June 2017. == History == In 2014 when Jonsi Stefansson joined as CEO, Greenqloud pivoted its operational focus to development of Qstack with beta launch in the fall of 2015, and began offering support, technical services and certifications for the software. == Features == Qstack is hypervisor agnostic (KVM, VMware, Hyper-V) and can manage private clouds in multiple locations as well as AWS, Azure, and EC2-compatible public clouds from its user interface. Qstack combines proprietary software with open-source components, and the company claims to harden them to meet the strict security standards often required by enterprise deployments. Qstack features VM templates for Windows, Linux, and other operating systems. It also features full SSH/RDP access to instances, virtual routers, firewalls, and load balancers built into the interface. == Reception == In a 2015 review, IDG columnist J. Peter Bruzzese praised Qstack’s user interface for its ease-of-use and clean look.
Biomedical data science
Biomedical data science is a multidisciplinary field which leverages large volumes of data to promote biomedical innovation and discovery. Biomedical data science draws from various fields including Biostatistics, Biomedical informatics, and machine learning, with the goal of understanding biological and medical data. It can be viewed as the study and application of data science to solve biomedical problems. Modern biomedical datasets often have specific features which make their analyses difficult, including: Large numbers of feature (sometimes billions), typically far larger than the number of samples (typically tens or hundreds) Noisy and missing data Privacy concerns (e.g., electronic health record confidentiality) Requirement of interpretability from decision makers and regulatory bodies Many biomedical data science projects apply machine learning to such datasets. These characteristics, while also present in many data science applications more generally, make biomedical data science a specific field. Examples of biomedical data science research include: Computational genomics Computational imaging Electronic health records data mining Biomedical network science Clinical Natural Language Processing (NLP) == Computational Imaging and Deep Learning == Computational imaging is a cornerstone of biomedical data science, focusing on the development of algorithms to enhance, analyze, and interpret medical imagery. In recent years, the field has been transformed by the integration of deep learning, particularly through the use of Convolutional Neural Networks. Deep learning started from researchers manually defining characteristics like edge detection or texture representation learning. In a more modern approach of computational imaging, models automatically learn a hierarchy of features directly from raw pixel data. This overlap between data science and deep learning is applied across several key tasks: Classification: Identifying the presence of specific diseases, such as distinguishing between benign and malignant tumors in histopathology slides or detecting pneumonia in chest X-rays. Segmentation: The precise delineation of anatomical structures or lesions. A notable example is the U-Net architecture, which is widely used for biomedical image segmentation to help clinicians quantify organ volume or track tumor growth. Detection: Automating the localization of small objects, such as identifying microcalcifications in mammograms or polyps during colonoscopies. Registration: The process of aligning multiple images to provide a comprehensive view of the patient's anatomy. Even with all of these enhancements, the application of deep learning in medical imaging requires accomplishing vigorous challenges. An example of these changes is building large, annotated datasets and creating the imperative for model interpretability in clinical decision-making. == Electronic Health Records == Electronic Health Records (EHRs) are a digital alternative to patient paper charts, usually including individual records or population health information. EHRs can be used in a wide variety of applications, including research and analysation as they often include demographics, diagnoses, medications, test results, and personal statistics. === History === ==== 1960s ==== The earliest precursor is considered Dr. Lawrence Weed's problem-oriented medical record (POMR) published in the 1968 which sorts and groups medical records by medical diagnoses and symptoms. The POMR was the first system to organize based off of patient information rather than the source (doctors, nurses, attendings, etc.). In 1969, the Regenstrief Institute developed and published the Regenstrief Medical Record System which established electronic writing, storage, and retrieval of records which served as the basis for modern EHR systems. ==== 2000s ==== In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH Act) was passed in the United States. This act standardized privacy and distribution of EHRs and increased the acceptance and utilization of EHRs within medical and academic settings. == Artificial Intelligence and Machine Learning Applications == Machine Learning and Artificial Intelligence have become central tools in biomedical data science. Recent advances in large language models (LLMs) have expanded their role beyond text, with models trained directly on genomic sequences enabling tasks such as gene function prediction, variant effect analysis, and drug discovery. In clinical settings, Natural Language Processing (NLP) models are applied to electronic health records to extract structured insights from unstructured clinical notes and data, supporting diagnosis and treatment planning. Beyond genomics, AI models have been applied to protein structure prediction. AlphaFold, developed by Google DeepMind, uses deep learning to predict three-dimensional protein structures from amino acid sequences with high accuracy. These predictions have been used to support drug target identification and the study of disease mechanisms. == Knowledge Graphs == Knowledge graphs (KGs) are widely used in biomedical data science to represent and analyze complex relationships among biological and medical entities. By structuring data as nodes (e.g., genes, diseases, drugs) and edges (relationships), KGs enable computational methods to extract insights and support decision-making. These biomedical relationships can be efficiently modeled and queried using technologies such as Neo4j. === Biomedical Research Applications === KGs provide biomedical researchers with a way to model complex biological systems. They have been used to identify the relationships between diseases and biomolecules, support drug repurposing, and to uncover new biological insights. Additional applications include: Identification of novel antibiotic resistance genes through graph-based link prediction. Finding associations between miRNA and diseases. Prediction of protein-protein interactions. === Clinical Applications === In clinical settings, KGs can be used to make visual representations of a patient's electronic health records. The data obtained from these graphs can assist healthcare providers in improving patient diagnoses and prescribing more effective drugs. Additionally, embeddings derived from resources like the Unified Medical Language System (UMLS) enable natural language processing of clinical text and similarity analysis between medical concepts. === Limitations === Despite their advantages, knowledge graphs face several challenges. Some of these include: High algorithmic complexity and large biological datasets make the process computationally expensive. KG construction can be a time-consuming process that requires careful attention to assign appropriate node types and vocabularies. Using data from a wide range of datasets in one KG requires them to be effectively integrated. == Privacy == A primary challenge in biomedical data science is maintaining medical privacy. Conducting research requires that data be collected on a number of people for training and testing purposes and is stored within biomedical datasets. This poses a risk for violating patient confidentiality and may dissuade people from participating in studies. The main sources of health statistics are surveys administrative and medical records health care claims data, vital records surveillance disease registries grey literature and peer-reviewed literature. Large data collection is a useful tool for researching various medical conditions. Researchers use these large datasets of information to identify factors that may make people more susceptible to certain diseases. Large amounts of collected data can help researchers identify patterns for disease probabilities. The findings can show a person is more likely for a condition, or identify environmental, social, and personal habits that may lead to adverse health issues. Institutions researching using personal medical information come with a moral and legal responsibility to protect the use of that information. Protection of the collected information has become a big concern. Sophisticated and coordinated attacks on certain medical systems happen more frequently. Medical companies, medical insurance and private businesses have invested a great deal into the protection of personal data. Despite this, data breaches continue to be documented. The chart below shows the top healthcare breaches in 2025. For these reasons, many people have reservations about giving up their personal data. Aside from the legitimate use of personal data there have been instances where companies have found methods to profit from brokering medical information. Concerns exist regarding unauthorized use of sensitive information within these data companies. If a person is identified within a dataset, then sensitive data can be used to discriminate against them. For example, insurance companies may charge a hi
Business Controls Corporation
Business Controls Corporation is a privately held computer company that developed an application-program-generator and also a series of accounting software packages. These packages were widely enough used for various business magazines to have back-of-the-book ads for companies seeking accountants with experience in one or more of them. Computer magazines ran coverage for their SB-5 application-program-generator as from time to time new versions were released, each with new or improved features. == Early days == The company's initial offerings were packages for the DEC PDP-8, although Business Controls Corporation also wrote custom-written programs for customers. Large customers with mainframes who also used smaller systems for departmental use and distributed processing also used BCC's services. == SB-5 == The addition of an application-program-generator named SB-5 that, from specifications, could generate COBOL code was a major step forward. Although this began with supporting the DEC PDP-11, they subsequently began to support COBOL on DEC's DECsystem-10 & DECSYSTEM-20. VAX support came later. The specifications also permitted COBOL inserts and overrides: SB-5 could build an application that was all COBOL, yet only code the portions that varied from BCC's "vanilla" accounting packages. === Similar offerings === A similar idea was done for the IBM mainframe world in the form of a series of application-program-generators from Dylakor Corporation. They were named DYL-250, DYL-260, DYL-270 & DYL-280. Dylakor was acquired by Computer Associates. The specific syntax was different, but it had wider use, and - a mark of success and recognition in the industry - syntax-compatible implementations were released by a competitor. Still another alternative was Peat Marwick Mitchell's PMM2170 application-program-generator package. Like the others, it supported COBOL inserts and overrides. === Extended integration === Business Controls Corporation subsequently extended SB-5's feature set to provide support for System 1022, a product for the DECsystem-10 & DECSYSTEM-20; 1022's vendor also had a VAX/VMS (later OpenVMS) product, System 1032.
Phrase structure grammar
The term phrase structure grammar was originally introduced by Noam Chomsky as the term for grammar studied previously by Emil Post and Axel Thue (Post canonical systems). Some authors, however, reserve the term for more restricted grammars in the Chomsky hierarchy: context-sensitive grammars or context-free grammars. In a broader sense, phrase structure grammars are also known as constituency grammars. The defining character of phrase structure grammars is thus their adherence to the constituency relation, as opposed to the dependency relation of dependency grammars. == History == In 1956, Chomsky wrote, "A phrase-structure grammar is defined by a finite vocabulary (alphabet) Vp, and a finite set Σ of initial strings in Vp, and a finite set F of rules of the form: X → Y, where X and Y are strings in Vp." == Constituency relation == In linguistics, phrase structure grammars are all those grammars that are based on the constituency relation, as opposed to the dependency relation associated with dependency grammars; hence, phrase structure grammars are also known as constituency grammars. Any of several related theories for the parsing of natural language qualify as constituency grammars, and most of them have been developed from Chomsky's work, including Government and binding theory Generalized phrase structure grammar Head-driven phrase structure grammar Lexical functional grammar The minimalist program Nanosyntax Further grammar frameworks and formalisms also qualify as constituency-based, although they may not think of themselves as having spawned from Chomsky's work, e.g. Arc pair grammar, and Categorial grammar.
ImHex
ImHex is a free cross-platform hex editor available on Windows, macOS, and Linux. ImHex is used by programmers and reverse engineers to view and analyze binary data. == History == The initial release of the project in November 2020, saw significant interest on GitHub. == Features == Features include: Hex editor Custom pattern matching and analysis scripting language Visual, node based data pre-processor Disassembler Running and visualizing of YARA rules Bookmarks Binary data diffing Additional Tools MSVC, Itanium, D and Rust name demangler ASCII table Calculator Base converter File utilities IEEE 754 floating point decoder Division by invariant multiplication calculator TCP/IP client and server Support for: Data importing and exporting ASCII string, Unicode string, numeric, hexadecimal and regular expressions search Byte manipulation File hashing Plug-ins