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Machine vision

Machine vision is the technology and methods used to provide imaging-based automatic inspection and analysis for such applications as automatic inspection, process control, and robot guidance, usually in industry. Machine vision refers to many technologies, software and hardware products, integrated systems, actions, methods and expertise. Machine vision as a systems engineering discipline can be considered distinct from computer vision, a form of computer science. It attempts to integrate existing technologies in new ways and apply them to solve real world problems. The term is the prevalent one for these functions in industrial automation environments but is also used for these functions in other environment vehicle guidance. The overall machine vision process includes planning the details of the requirements and project, and then creating a solution. During run-time, the process starts with imaging, followed by automated analysis of the image and extraction of the required information. == Definition == Definitions of the term "Machine vision" vary, but all include the technology and methods used to extract information from an image on an automated basis, as opposed to image processing, where the output is another image. The information extracted can be a simple good-part/bad-part signal, or more a complex set of data such as the identity, position and orientation of each object in an image. The information can be used for such applications as automatic inspection and robot and process guidance in industry, for security monitoring and vehicle guidance. This field encompasses a large number of technologies, software and hardware products, integrated systems, actions, methods and expertise. Machine vision is practically the only term used for these functions in industrial automation applications; the term is less universal for these functions in other environments such as security and vehicle guidance. Machine vision as a systems engineering discipline can be considered distinct from computer vision, a form of basic computer science; machine vision attempts to integrate existing technologies in new ways and apply them to solve real world problems in a way that meets the requirements of industrial automation and similar application areas. The term is also used in a broader sense by trade shows and trade groups such as the Automated Imaging Association and the European Machine Vision Association. This broader definition also encompasses products and applications most often associated with image processing. The primary uses for machine vision are automatic inspection and industrial robot/process guidance. In more recent times the terms computer vision and machine vision have converged to a greater degree. See glossary of machine vision. == Imaging based automatic inspection and sorting == The primary uses for machine vision are imaging-based automatic inspection and sorting and robot guidance.; in this section the former is abbreviated as "automatic inspection". The overall process includes planning the details of the requirements and project, and then creating a solution. This section describes the technical process that occurs during the operation of the solution. === Methods and sequence of operation === The first step in the automatic inspection sequence of operation is acquisition of an image, typically using cameras, lenses, and lighting that has been designed to provide the differentiation required by subsequent processing. MV software packages and programs developed in them then employ various digital image processing techniques to extract the required information, and often make decisions (such as pass/fail) based on the extracted information. === Equipment === The components of an automatic inspection system usually include lighting, a camera or other imager, a processor, software, and output devices. === Imaging === The imaging device (e.g. camera) can either be separate from the main image processing unit or combined with it in which case the combination is generally called a smart camera or smart sensor. Inclusion of the full processing function into the same enclosure as the camera is often referred to as embedded processing. When separated, the connection may be made to specialized intermediate hardware, a custom processing appliance, or a frame grabber within a computer using either an analog or standardized digital interface (Camera Link, CoaXPress). MV implementations also use digital cameras capable of direct connections (without a framegrabber) to a computer via FireWire, USB or Gigabit Ethernet interfaces. While conventional (2D visible light) imaging is most commonly used in MV, alternatives include multispectral imaging, hyperspectral imaging, imaging various infrared bands, line scan imaging, 3D imaging of surfaces and X-ray imaging. Key differentiations within MV 2D visible light imaging are monochromatic vs. color, frame rate, resolution, and whether or not the imaging process is simultaneous over the entire image, making it suitable for moving processes. Though the vast majority of machine vision applications are solved using two-dimensional imaging, machine vision applications utilizing 3D imaging are a growing niche within the industry. The most commonly used method for 3D imaging is scanning based triangulation which utilizes motion of the product or image during the imaging process. A laser is projected onto the surfaces of an object. In machine vision this is accomplished with a scanning motion, either by moving the workpiece, or by moving the camera & laser imaging system. The line is viewed by a camera from a different angle; the deviation of the line represents shape variations. Lines from multiple scans are assembled into a depth map or point cloud. Stereoscopic vision is used in special cases involving unique features present in both views of a pair of cameras. Other 3D methods used for machine vision are time of flight and grid based. One method is grid array based systems using pseudorandom structured light system as employed by the Microsoft Kinect system circa 2012. === Image processing === After an image is acquired, it is processed. Central processing functions are generally done by a CPU, a GPU, a FPGA or a combination of these. Deep learning training and inference impose higher processing performance requirements. Multiple stages of processing are generally used in a sequence that ends up as a desired result. A typical sequence might start with tools such as filters which modify the image, followed by extraction of objects, then extraction (e.g. measurements, reading of codes) of data from those objects, followed by communicating that data, or comparing it against target values to create and communicate "pass/fail" results. Machine vision image processing methods include; Stitching/Registration: Combining of adjacent 2D or 3D images. Filtering (e.g. morphological filtering) Thresholding: Thresholding starts with setting or determining a gray value that will be useful for the following steps. The value is then used to separate portions of the image, and sometimes to transform each portion of the image to simply black and white based on whether it is below or above that grayscale value. Pixel counting: counts the number of light or dark pixels Segmentation: Partitioning a digital image into multiple segments to simplify and/or change the representation of an image into something that is more meaningful and easier to analyze. Edge detection: finding object edges Color Analysis: Identify parts, products and items using color, assess quality from color, and isolate features using color. Blob detection and extraction: inspecting an image for discrete blobs of connected pixels (e.g. a black hole in a grey object) as image landmarks. Neural network / deep learning / machine learning processing: weighted and self-training multi-variable decision making Circa 2019 there is a large expansion of this, using deep learning and machine learning to significantly expand machine vision capabilities. The most common result of such processing is classification. Examples of classification are object identification,"pass fail" classification of identified objects and OCR. Pattern recognition including template matching. Finding, matching, and/or counting specific patterns. This may include location of an object that may be rotated, partially hidden by another object, or varying in size. Barcode, Data Matrix and "2D barcode" reading Optical character recognition: automated reading of text such as serial numbers Gauging/Metrology: measurement of object dimensions (e.g. in pixels, inches or millimeters) Comparison against target values to determine a "pass or fail" or "go/no go" result. For example, with code or bar code verification, the read value is compared to the stored target value. For gauging, a measurement is compared against the proper value and tolerances. For verification of alpha-numberic codes, the
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Virtual assistant

A virtual assistant (VA) is a software agent that can perform a range of tasks or services for a user based on user input, such as commands or questions, including verbal ones. Such technologies often incorporate chatbot capabilities to streamline task execution. The interaction may be via text, graphical interface, or voice, as some virtual assistants are able to interpret human speech and respond via synthesized voices. In many cases, users can ask their virtual assistants questions, control home automation devices and media playback, and manage other basic tasks such as email, to-do lists, and calendars – all with verbal commands. In recent years, prominent virtual assistants for direct consumer use have included Apple Siri, Amazon Alexa, Google Assistant (Gemini), Microsoft Copilot and Samsung Bixby. Also, companies in various industries often incorporate some kind of virtual assistant technology into their customer service or support. Into the 2020s, the emergence of artificial intelligence based chatbots, such as ChatGPT, has brought increased capability and interest to the field of virtual assistant products and services. == History == === Experimental decades: 1910s–1980s === Radio Rex was the first voice-activated toy, patented in 1916 and released in 1922. It was a wooden toy in the shape of a dog that would come out of its house when its name is called. In 1952, Bell Labs presented "Audrey", the Automatic Digit Recognition machine. It occupied a six-foot-high relay rack, consumed substantial power, had streams of cables and exhibited the myriad maintenance problems associated with complex vacuum-tube circuitry. It could recognize the fundamental units of speech, phonemes. It was limited to the accurate recognition of digits spoken by designated talkers. It could therefore be used for voice dialing, but in most cases, push-button dialing was cheaper and faster, rather than speaking the consecutive digits. Another early tool which was enabled to perform digital speech recognition was the IBM Shoebox voice-activated calculator, presented to the general public during the 1962 Seattle World's Fair after its initial market launch in 1961. This early computer, developed almost 20 years before the introduction of the first IBM Personal Computer in 1981, was able to recognize 16 spoken words and the digits 0 to 9. The first natural language processing computer program or the chatbot ELIZA was developed by MIT professor Joseph Weizenbaum in the 1960s. It was created to "demonstrate that the communication between man and machine was superficial". ELIZA used pattern matching and substitution methodology into scripted responses to simulate conversation, which gave an illusion of understanding on the part of the program. Weizenbaum's own secretary reportedly asked Weizenbaum to leave the room so that she and ELIZA could have a real conversation. Weizenbaum was surprised by this, later writing: "I had not realized ... that extremely short exposures to a relatively simple computer program could induce powerful delusional thinking in quite normal people. This gave name to the ELIZA effect, the tendency to unconsciously assume computer behaviors are analogous to human behaviors; that is, anthropomorphisation, a phenomenon present in human interactions with virtual assistants. The next milestone in the development of voice recognition technology was achieved in the 1970s at the Carnegie Mellon University in Pittsburgh, Pennsylvania with substantial support of the United States Department of Defense and its DARPA agency, funded five years of a Speech Understanding Research program, aiming to reach a minimum vocabulary of 1,000 words. Companies and academia including IBM, Carnegie Mellon University (CMU) and Stanford Research Institute took part in the program. The result was "Harpy", it mastered about 1000 words, the vocabulary of a three-year-old and it could understand sentences. It could process speech that followed pre-programmed vocabulary, pronunciation, and grammar structures to determine which sequences of words made sense together, and thus reducing speech recognition errors. In 1986, Tangora was an upgrade of the Shoebox, it was a voice recognizing typewriter. Named after the world's fastest typist at the time, it had a vocabulary of 20,000 words and used prediction to decide the most likely result based on what was said in the past. IBM's approach was based on a hidden Markov model, which adds statistics to digital signal processing techniques. The method makes it possible to predict the most likely phonemes to follow a given phoneme. Still each speaker had to individually train the typewriter to recognize their voice, and pause between each word. In 1983, Gus Searcy invented the "Butler in a Box", an electronic voice home controller system. === Birth of smart virtual assistants: 1990s–2010s === In the 1990s, digital speech recognition technology became a feature of the personal computer with IBM, Philips and Lernout & Hauspie fighting for customers. Much later the market launch of the first smartphone IBM Simon in 1994 laid the foundation for smart virtual assistants as we know them today. In 1997, Dragon's NaturallySpeaking software could recognize and transcribe natural human speech without pauses between each word into a document at a rate of 100 words per minute. A version of Naturally Speaking is still available for download and it is still used today, for instance, by many doctors in the US and the UK to document their medical records. In 2001 Colloquis publicly launched SmarterChild, on platforms like AIM and MSN Messenger. While entirely text-based SmarterChild was able to play games, check the weather, look up facts, and converse with users to an extent. The first modern digital virtual assistant installed on a smartphone was Siri, which was introduced as a feature of the iPhone 4S on 4 October 2011. Apple Inc. developed Siri following the 2010 acquisition of Siri Inc., a spin-off of SRI International, which is a research institute financed by DARPA and the United States Department of Defense. Its aim was to aid in tasks such as sending a text message, making phone calls, checking the weather or setting up an alarm. Over time, it has developed to provide restaurant recommendations, search the internet, and provide driving directions. In November 2014, Amazon announced Alexa alongside the Echo. In 2016, Salesforce debuted Einstein, developed from a set of technologies underlying the Salesforce platform. Einstein was replaced by Agentforce, an agentic AI, in September 2024. In April 2017 Amazon released a service for building conversational interfaces for any type of virtual assistant or interface. === Large Language Models: 2020s-present === In the 2020s, artificial intelligence (AI) systems like ChatGPT have gained popularity for their ability to generate human-like responses to text-based conversations. In February 2020, Microsoft introduced its Turing Natural Language Generation (T-NLG), which was then the "largest language model ever published at 17 billion parameters." On November 30, 2022, ChatGPT was launched as a prototype and quickly garnered attention for its detailed responses and articulate answers across many domains of knowledge. The advent of ChatGPT and its introduction to the wider public increased interest and competition in the space. In February 2023, Google began introducing an experimental service called "Bard" which is based on its LaMDA program to generate text responses to questions asked based on information gathered from the web. While ChatGPT and other generalized chatbots based on the latest generative AI are capable of performing various tasks associated with virtual assistants, there are also more specialized forms of such technology that are designed to target more specific situations or needs. == Method of interaction == Virtual assistants work via: Text, including: online chat (especially in an instant messaging application or other application ), SMS text, e-mail or other text-based communication channel, for example Conversica's intelligent virtual assistants for business. Voice: for example with Amazon Alexa on Amazon Echo devices, Siri on an iPhone, Google Assistant on Google-enabled Android devices, or Bixby on Samsung devices. Images: some assistants, such as Google Assistant (which includes Google Lens) and Bixby on the Samsung Galaxy series, have the added capability of performing image processing to recognize objects in images. Many virtual assistants are accessible via multiple methods, offering versatility in how users can interact with them, whether through chat, voice commands, or other integrated technologies. Virtual assistants use natural language processing (NLP) to match user text or voice input to executable commands. Some continually learn using artificial intelligence techniques including machine learning and ambient intelligence. To activate a virtual assistant u
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Normal distributions transform

The normal distributions transform (NDT) is a point cloud registration algorithm introduced by Peter Biber and Wolfgang Straßer in 2003, while working at University of Tübingen. The algorithm registers two point clouds by first associating a piecewise normal distribution to the first point cloud, that gives the probability of sampling a point belonging to the cloud at a given spatial coordinate, and then finding a transform that maps the second point cloud to the first by maximising the likelihood of the second point cloud on such distribution as a function of the transform parameters. Originally introduced for 2D point cloud map matching in simultaneous localization and mapping (SLAM) and relative position tracking, the algorithm was extended to 3D point clouds and has wide applications in computer vision and robotics. NDT is very fast and accurate, making it suitable for application to large scale data, but it is also sensitive to initialisation, requiring a sufficiently accurate initial guess, and for this reason it is typically used in a coarse-to-fine alignment strategy. == Formulation == The NDT function associated to a point cloud is constructed by partitioning the space in regular cells. For each cell, it is possible to define the mean q = 1 n ∑ i x i {\displaystyle \textstyle \mathbf {q} ={\frac {1}{n}}\sum _{i}\mathbf {x_{i}} } and covariance S = 1 n ∑ i ( x i − q ) ( x i − q ) ⊤ {\displaystyle \textstyle \mathbf {S} ={\frac {1}{n}}\sum _{i}\left(\mathbf {x} _{i}-\mathbf {q} \right)\left(\mathbf {x} _{i}-\mathbf {q} \right)^{\top }} of the n {\displaystyle n} points of the cloud x 1 , … , x n {\displaystyle \mathbf {x} _{1},\dots ,\mathbf {x} _{n}} that fall within the cell. The probability density of sampling a point at a given spatial location x {\displaystyle \mathbf {x} } within the cell is then given by the normal distribution e − 1 2 ( x − q ) ⊤ S − 1 ( x − q ) {\displaystyle e^{-{\frac {1}{2}}\left(\mathbf {x} -\mathbf {q} \right)^{\top }\mathbf {S} ^{-1}\left(\mathbf {x} -\mathbf {q} \right)}} . Two point clouds can be mapped by a Euclidean transformation f {\displaystyle f} with rotation matrix R {\displaystyle \mathbf {R} } and translation vector t {\displaystyle \mathbf {t} } f R , t ( x ) = R x + t {\displaystyle f_{\mathbf {R} ,\mathbf {t} }(\mathbf {x} )=\mathbf {R} \mathbf {x} +\mathbf {t} } that maps from the second cloud to the first, parametrised by the rotation angles and translation components. The algorithm registers the two point clouds by optimising the parameters of the transformation that maps the second cloud to the first, with respect to a loss function based on the NDT of the first point cloud, solving the following problem arg ⁡ min R , t { − ∑ i NDT ⁡ ( f R , t ( x i ) ) } {\displaystyle \arg \min _{\mathbf {R} ,\mathbf {t} }\left\{-\sum _{i}\operatorname {NDT} \left(f_{\mathbf {R} ,\mathbf {t} }\left(\mathbf {x_{i}} \right)\right)\right\}} where the loss function represents the negated likelihood, obtained by applying the transformation to all points in the second cloud and summing the value of the NDT at each transformed point f R , t ( x ) {\displaystyle f_{\mathbf {R} ,\mathbf {t} }(\mathbf {x} )} . The loss is piecewise continuous and differentiable, and can be optimised with gradient-based methods (in the original formulation, the authors use Newton's method). In order to reduce the effect of cell discretisation, a technique consists of partitioning the space into multiple overlapping grids, shifted by half cell size along the spatial directions, and computing the likelihood at a given location as the sum of the NDTs induced by each grid.
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Application performance engineering

Application performance engineering is a method to develop and test application performance in various settings, including mobile computing, the cloud, and conventional information technology (IT). == Methodology == According to the American National Institute of Standards and Technology, nearly four out of every five dollars spent on the total cost of ownership of an application is directly attributable to finding and fixing issues post-deployment. A full one-third of this cost could be avoided with better software testing. Application performance engineering attempts to test software before it is published. While practices vary among organizations, the method attempts to emulate the real-world conditions that software in development will confront, including network deployment and access by mobile devices. Techniques include network virtualization.
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Control system

A control system manages, commands, directs, or regulates the behavior of other devices or systems using control loops. It can range from a single home heating controller using a thermostat controlling a domestic boiler to large industrial control systems which are used for controlling processes or machines. The control systems are designed via control engineering process. For continuously modulated control, a feedback controller is used to automatically control a process or operation. The control system compares the value or status of the process variable (PV) being controlled with the desired value or setpoint (SP), and applies the difference as a control signal to bring the process variable output of the plant to the same value as the setpoint. For sequential and combinational logic, software logic, such as in a programmable logic controller, is used. == Open-loop and closed-loop control == == Feedback control systems == == Logic control == Logic control systems for industrial and commercial machinery were historically implemented by interconnected electrical relays and cam timers using ladder logic. Today, most such systems are constructed with microcontrollers or more specialized programmable logic controllers (PLCs). The notation of ladder logic is still in use as a programming method for PLCs. Logic controllers may respond to switches and sensors and can cause the machinery to start and stop various operations through the use of actuators. Logic controllers are used to sequence mechanical operations in many applications. Examples include elevators, washing machines and other systems with interrelated operations. An automatic sequential control system may trigger a series of mechanical actuators in the correct sequence to perform a task. For example, various electric and pneumatic transducers may fold and glue a cardboard box, fill it with the product and then seal it in an automatic packaging machine. PLC software can be written in many different ways – ladder diagrams, SFC (sequential function charts) or statement lists. == On–off control == On–off control uses a feedback controller that switches abruptly between two states. A simple bi-metallic domestic thermostat can be described as an on-off controller. When the temperature in the room (PV) goes below the user setting (SP), the heater is switched on. Another example is a pressure switch on an air compressor. When the pressure (PV) drops below the setpoint (SP) the compressor is powered. Refrigerators and vacuum pumps contain similar mechanisms. Simple on–off control systems like these can be cheap and effective. == Linear control == == Fuzzy logic == Fuzzy logic is an attempt to apply the easy design of logic controllers to the control of complex continuously varying systems. Basically, a measurement in a fuzzy logic system can be partly true. The rules of the system are written in natural language and translated into fuzzy logic. For example, the design for a furnace would start with: "If the temperature is too high, reduce the fuel to the furnace. If the temperature is too low, increase the fuel to the furnace." Measurements from the real world (such as the temperature of a furnace) are fuzzified and logic is calculated arithmetic, as opposed to Boolean logic, and the outputs are de-fuzzified to control equipment. When a robust fuzzy design is reduced to a single, quick calculation, it begins to resemble a conventional feedback loop solution and it might appear that the fuzzy design was unnecessary. However, the fuzzy logic paradigm may provide scalability for large control systems where conventional methods become unwieldy or costly to derive. Fuzzy electronics is an electronic technology that uses fuzzy logic instead of the two-value logic more commonly used in digital electronics. == Physical implementation == The range of control system implementation is from compact controllers often with dedicated software for a particular machine or device, to distributed control systems for industrial process control for a large physical plant. Logic systems and feedback controllers are usually implemented with programmable logic controllers. The Broadly Reconfigurable and Expandable Automation Device (BREAD) is a recent framework that provides many open-source hardware devices which can be connected to create more complex data acquisition and control systems.
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Convolutional layer

In artificial neural networks, a convolutional layer is a type of network layer that applies a convolution operation to the input. Convolutional layers are some of the primary building blocks of convolutional neural networks (CNNs), a class of neural network most commonly applied to images, video, audio, and other data that have the property of uniform translational symmetry. The convolution operation in a convolutional layer involves sliding a small window (called a kernel or filter) across the input data and computing the dot product between the values in the kernel and the input at each position. This process creates a feature map that represents detected features in the input. == Concepts == === Kernel === Kernels, also known as filters, are small matrices of weights that are learned during the training process. Each kernel is responsible for detecting a specific feature in the input data. The size of the kernel is a hyperparameter that affects the network's behavior. === Convolution === For a 2D input x {\displaystyle x} and a 2D kernel w {\displaystyle w} , the 2D convolution operation can be expressed as: y [ i , j ] = ∑ m = 0 k h − 1 ∑ n = 0 k w − 1 x [ i + m , j + n ] ⋅ w [ m , n ] {\displaystyle y[i,j]=\sum _{m=0}^{k_{h}-1}\sum _{n=0}^{k_{w}-1}x[i+m,j+n]\cdot w[m,n]} where k h {\displaystyle k_{h}} and k w {\displaystyle k_{w}} are the height and width of the kernel, respectively. This generalizes immediately to nD convolutions. Commonly used convolutions are 1D (for audio and text), 2D (for images), and 3D (for spatial objects, and videos). === Stride === Stride determines how the kernel moves across the input data. A stride of 1 means the kernel shifts by one pixel at a time, while a larger stride (e.g., 2 or 3) results in less overlap between convolutions and produces smaller output feature maps. === Padding === Padding involves adding extra pixels around the edges of the input data. It serves two main purposes: Preserving spatial dimensions: Without padding, each convolution reduces the size of the feature map. Handling border pixels: Padding ensures that border pixels are given equal importance in the convolution process. Common padding strategies include: No padding/valid padding. This strategy typically causes the output to shrink. Same padding: Any method that ensures the output size same as input size is a same padding strategy. Full padding: Any method that ensures each input entry is convolved over for the same number of times is a full padding strategy. Common padding algorithms include: Zero padding: Add zero entries to the borders of input. Mirror/reflect/symmetric padding: Reflect the input array on the border. Circular padding: Cycle the input array back to the opposite border, like a torus. The exact numbers used in convolutions is complicated, for which we refer to (Dumoulin and Visin, 2018) for details. == Variants == === Standard === The basic form of convolution as described above, where each kernel is applied to the entire input volume. === Depthwise separable === Depthwise separable convolution separates the standard convolution into two steps: depthwise convolution and pointwise convolution. The depthwise separable convolution decomposes a single standard convolution into two convolutions: a depthwise convolution that filters each input channel independently and a pointwise convolution ( 1 × 1 {\displaystyle 1\times 1} convolution) that combines the outputs of the depthwise convolution. This factorization significantly reduces computational cost. It was first developed by Laurent Sifre during an internship at Google Brain in 2013 as an architectural variation on AlexNet to improve convergence speed and model size. === Dilated === Dilated convolution, or atrous convolution, introduces gaps between kernel elements, allowing the network to capture a larger receptive field without increasing the kernel size. === Transposed === Transposed convolution, also known as deconvolution, fractionally strided convolution, and upsampling convolution, is a convolution where the output tensor is larger than its input tensor. It's often used in encoder-decoder architectures for upsampling. It's used in image generation, semantic segmentation, and super-resolution tasks. == History == The concept of convolution in neural networks was inspired by the visual cortex in biological brains. Early work by Hubel and Wiesel in the 1960s on the cat's visual system laid the groundwork for artificial convolution networks. An early convolution neural network was developed by Kunihiko Fukushima in 1969. It had mostly hand-designed kernels inspired by convolutions in mammalian vision. In 1979 he improved it to the Neocognitron, which learns all convolutional kernels by unsupervised learning (in his terminology, "self-organized by 'learning without a teacher'"). During the 1988 to 1998 period, a series of CNN were introduced by Yann LeCun et al., ending with LeNet-5 in 1998. It was an early influential CNN architecture for handwritten digit recognition, trained on the MNIST dataset, and was used in ATM. (Olshausen & Field, 1996) discovered that simple cells in the mammalian primary visual cortex implement localized, oriented, bandpass receptive fields, which could be recreated by fitting sparse linear codes for natural scenes. This was later found to also occur in the lowest-level kernels of trained CNNs. The field saw a resurgence in the 2010s with the development of deeper architectures and the availability of large datasets and powerful GPUs. AlexNet, developed by Alex Krizhevsky et al. in 2012, was a catalytic event in modern deep learning. In that year’s ImageNet competition, the AlexNet model achieved a 16% top-five error rate, significantly outperforming the next best entry, which had a 26% error rate. The network used eight trainable layers, approximately 650,000 neurons, and around 60 million parameters, highlighting the impact of deeper architectures and GPU acceleration on image recognition performance. From the 2013 ImageNet competition, most entries adopted deep convolutional neural networks, building on the success of AlexNet. Over the following years, performance steadily improved, with the top-five error rate falling from 16% in 2012 and 12% in 2013 to below 3% by 2017, as networks grew increasingly deep.
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Vector database

A vector database, vector store or vector search engine is a database that stores and retrieves embeddings of data in vector space. Vector databases typically implement approximate nearest neighbor algorithms so users can search for records semantically similar to a given input, unlike traditional databases which primarily look up records by exact match. Use-cases for vector databases include similarity search, semantic search, multi-modal search, recommendations engines, object detection, and retrieval-augmented generation (RAG). Vector embeddings are mathematical representations of data in a high-dimensional space. In this space, each dimension corresponds to a feature of the data, with the number of dimensions ranging from a few hundred to tens of thousands, depending on the complexity of the data being represented. Each data item is represented by one vector in this space. Words, phrases, or entire documents, as well as images, audio, and other types of data, can all be vectorized. These feature vectors may be computed from the raw data using machine learning methods such as feature extraction algorithms, word embeddings or deep learning networks. The goal is that semantically similar data items receive feature vectors close to each other. Vector retrieval can be combined with metadata filtering or lexical search to support filtered and hybrid retrieval workflows. == Techniques == Common techniques for similarity search on high-dimensional vectors include: Hierarchical Navigable Small World (HNSW) graphs Locality-sensitive hashing (LSH) and sketching Product quantization (PQ) Inverted files These techniques may also be combined in vector search systems. In recent benchmarks, HNSW-based implementations have been among the best performers. Conferences such as the International Conference on Similarity Search and Applications (SISAP) and the Conference on Neural Information Processing Systems (NeurIPS) have hosted competitions on vector search in large databases. == Applications == Vector databases are used in a wide range of machine learning applications including similarity search, semantic search, multi-modal search, recommendations engines, object detection, and retrieval-augmented generation. === Retrieval-augmented generation === An especially common use-case for vector databases is in retrieval-augmented generation (RAG), a method to improve domain-specific responses of large language models. The retrieval component of a RAG can be any search system, but is most often implemented as a vector database. Text documents describing the domain of interest are collected, and for each document or document section, a feature vector (known as an "embedding") is computed, typically using a deep learning network, and stored in a vector database along with a link to the document. Given a user prompt, the feature vector of the prompt is computed, and the database is queried to retrieve the most relevant documents. These are then automatically added into the context window of the large language model, and the large language model proceeds to create a response to the prompt given this context. == Implementations ==
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DeepSeek (chatbot)

DeepSeek is a generative artificial intelligence chatbot developed by the Chinese company DeepSeek. Released on 20 January 2025, DeepSeek-R1 surpassed ChatGPT as the most downloaded freeware app on the iOS App Store in the United States by 27 January. DeepSeek's success against larger and more established rivals has been described as "upending AI" and initiating "a global AI space race". DeepSeek's compliance with Chinese government censorship policies and its data collection practices have also raised concerns over privacy and information control in the model, prompting regulatory scrutiny in multiple countries. However, it has also been praised for its open weights and infrastructure code, energy efficiency and contributions to open-source artificial intelligence. == History == On 10 January 2025, DeepSeek released the chatbot, based on the DeepSeek-R1 model, for iOS and Android. By 27 January, DeepSeek-R1 surpassed ChatGPT as the most-downloaded freeware app on the iOS App Store in the United States, which resulted in an 18% drop in Nvidia's share price. And after a "large-scale" cyberattack on the same day disrupted the proper functioning of its servers, DeepSeek had limited its new user registration to phone numbers from mainland China, email addresses, or Google account logins. On 3 April 2025, in collaboration with researchers at Tsinghua University, DeepSeek published a paper unveiling a new model that combines the techniques generative reward modeling (GRM) and self-principled critique tuning (SPCT). The resulting model is referred to as DeepSeek-GRM. The goal of using these techniques is to foster more effective inference-time scaling within their LLM and chatbot services. Notably, DeepSeek has said that these new models will be released and made open source. On 30 April 2025, Deepseek released its math-focused Artificial Intelligence Model named "DeepSeek-Prover-V2-671B". This model is useful for formal theorem proving and mathematical reasoning. On 24 April 2026, DeepSeek released DeepSeek V4 and V4-Pro. == Usage == DeepSeek can answer questions, solve logic problems, and write computer programs on par with other chatbots, according to benchmark tests used by American AI companies. Users can access the chatbot for free through the official DeepSeek website or mobile application, without limitation on the number of queries. DeepSeek only supports user-signup via a global email service, e.g. Gmail, Google or Yahoo. DeepSeek also offers access to the R1 and V3 models that power the chatbot via an API with a usage-based pricing model. This modality is primarily targeted towards developers and businesses. As of February 2025, API usage is priced at approximately $0.28 per million input tokens and $0.42 per million output tokens, making it less expensive than some competing services. Its web version is completely free, with 500 messages per hour cap limit to prevent bots from spamming. == Operation == DeepSeek-V3 uses significantly fewer resources compared to its peers. For example, whereas the world's leading AI companies train their chatbots with supercomputers using as many as 16,000 graphics processing units (GPUs), DeepSeek claims to have needed only about 2,000 GPUs—namely, the H800 series chips from Nvidia. It was trained in around 55 days at a cost of US$5.58 million, which is roughly one-tenth of what tech giant Meta spent building its latest AI technology. == Reactions == DeepSeek's success against larger and more established rivals has been described as "upending AI", constituting "the first shot at what is emerging as a global AI space race", and ushering in "a new era of AI brinkmanship". === Challenge to US AI dominance === DeepSeek's competitive performance at relatively minimal cost has been recognized as potentially challenging the global dominance of American AI models. Various publications and news media, such as The Hill and The Guardian, have described the release of the R1 chatbot as a "Sputnik moment" for American AI, echoing Marc Andreessen's view. OpenAI wrote a letter to the Office of Science and Technology Policy (OSTP), in March 2025, citing issues concerning a possibility that Deepseek could manipulate responses to cause harm. === Chinese perspective === DeepSeek's founder Liang Wenfeng has been compared to OpenAI CEO Sam Altman, with CNN calling him the Sam Altman of China and an evangelist for AI. Chinese state media widely praised DeepSeek as a national asset. On 20 January 2025, Chinese Premier Li Qiang invited Wenfeng to his symposium with experts and asked him to provide opinions and suggestions on a draft for comments of the annual 2024 government work report. On 20 February 2025, Wenfeng met with General Secretary of the Chinese Communist Party Xi Jinping, who encouraged party and state leaders to experiment with DeepSeek. Government officials responded to Xi's approval of the chatbot by reportedly using it to draft legal judgements, propose medical treatment plans, and analyze surveillance videos to search for missing persons. === Performance and success === Leading figures in the American AI sector had mixed reactions to DeepSeek's performance and success. Microsoft CEO Satya Nadella and OpenAI CEO Altman—whose companies are involved in the United States government-backed "Stargate Project" to develop American AI infrastructure—both called DeepSeek "super impressive". Various companies including Amazon Web Services, Toyota, and Stripe are seeking to use the model in their program. When American President Donald Trump announced The Stargate Project, he referred to DeepSeek as a wake-up call and a positive development. Other leaders in the AI field, however—including Scale AI CEO Alexandr Wang, Anthropic cofounder and CEO Dario Amodei, and Elon Musk—have expressed skepticism of the app's performance or of the sustainability of its success. Wang in particularly referred to DeepSeek-V3 as "earth-shattering" and DeepSeek-R1 as "top performing, or roughly on par with the best American models", but speculated that China may possess more AI-powering Nvidia H100 GPUs than thought. === Stock market implications === DeepSeek's optimization of limited resources has highlighted potential limits of United States sanctions on China's AI development, including export restrictions on advanced AI chips to China. The success of the company's AI models consequently "sparked market turmoil" and caused shares in major global technology companies to plunge on 27 January 2025: Nvidia's stock fell by as much as 17–18%, as did the stock of rival Broadcom. Other tech firms also sank, including Microsoft (down 2.5%), Google's owner Alphabet (down over 4%), and Dutch chip equipment maker ASML (down over 7%). A global sell-off of technology stocks on Nasdaq, prompted by the release of the R1 model, led to record losses of about $593 billion in the market capitalizations of AI and computer hardware companies; and by the next day a total of $1 trillion of value was wiped from American stocks. == Concerns == === Distillation === DeepSeek has been reported to sometimes claim that it is ChatGPT. OpenAI said that DeepSeek may have "inappropriately" used outputs from its model as training data in a process called distillation. However, there is currently no method to prove this conclusively. === Censorship === DeepSeek's compliance with Chinese government censorship policies and its data collection practices have raised concerns over information control in the model, prompting regulatory scrutiny in multiple countries. Reports indicate that it applies content moderation in accordance with the government's "public opinion guidance" regulations, limiting responses on topics such as the Tiananmen Square massacre and Taiwan's political status. DeepSeek models that have been uncensored also display a bias towards Chinese government viewpoints on controversial topics such as Xi Jinping's human rights record and Taiwan's political status. However, users who have downloaded the models and hosted them on their own devices and servers have reported successfully removing this censorship. Some sources have observed that the official application programming interface (API) version of R1, which runs from servers located in mainland China, uses censorship mechanisms for topics considered politically sensitive for the government of China. For example, the model may initially generate answers to questions about the 1989 Tiananmen Square massacre, persecution of Uyghurs, comparisons between Xi Jinping and Winnie the Pooh, and human rights in China, but a censorship mechanism deletes the uncensored response afterwards and replaces it with a message such as:"Sorry, that's beyond my current scope. Let's talk about something else." The post hoc censorship mechanisms and restrictions added on top of the model's output can be removed in the open-source version of the R1 model. If the "core Socialist values" defined by the Chinese Internet regul
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Fluency Voice Technology

Fluency Voice Technology was a company that developed and sold packaged speech recognition solutions for use in call centers. Fluency's Speech Recognition solutions are used by call centers worldwide to improve customer service and significantly reduce costs and are available on-premises and hosted. == History == 1998 – Fluency was created as a spin-off from the Voice Research & Development team of a company called netdecisions. This R&D operation was established in Cambridge UK. The focus of the development was speech recognition systems based on the VXML standard. 2001 – Fluency became a separate entity in May 2001. Fluency began the creation of a software development platform specifically aimed at automating call center activities. This platform became Fluency's VoiceRunner. 2002 to 2004 – Fluency establishes accomplishes many successful deployments in customer sites such as National Express and Barclaycard. 2003 – Fluency expanded into the USA. Fluency also acquires Vocalis of Cambridge, UK in August 2003. 2004 – Fluency receives £6 million investment from leading European Venture Capitalists and establishes a global OEM partnership with Avaya, and the acquisition of SRC Telecom. 2008 – Fluency is acquired by Syntellect Ltd == Customers == Call Centers around the world use Fluency to improve service and reduce costs. They include Travelodge, Standard Life Bank, Sutton and East Surrey Water, Pizza Hut, CWT, Barclays, Powergen, First Choice, OutRight, J D Williams, Capital Blue Cross, Chelsea Building Society, EDF, bss, TV Licensing and Capita Software Services.
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Sentence extraction

Sentence extraction is a technique used for automatic summarization of a text. In this shallow approach, statistical heuristics are used to identify the most salient sentences of a text. Sentence extraction is a low-cost approach compared to more knowledge-intensive deeper approaches which require additional knowledge bases such as ontologies or linguistic knowledge. In short, sentence extraction works as a filter that allows only meaningful sentences to pass. The major downside of applying sentence-extraction techniques to the task of summarization is the loss of coherence in the resulting summary. Nevertheless, sentence extraction summaries can give valuable clues to the main points of a document and are frequently sufficiently intelligible to human readers. == Procedure == Usually, a combination of heuristics is used to determine the most important sentences within the document. Each heuristic assigns a (positive or negative) score to the sentence. After all heuristics have been applied, the highest-scoring sentences are included in the summary. The individual heuristics are weighted according to their importance. === Early approaches and some sample heuristics === Seminal papers which laid the foundations for many techniques used today have been published by Hans Peter Luhn in 1958 and H. P Edmundson in 1969. Luhn proposed to assign more weight to sentences at the beginning of the document or a paragraph. Edmundson stressed the importance of title-words for summarization and was the first to employ stop-lists in order to filter uninformative words of low semantic content (e.g. most grammatical words such as of, the, a). He also distinguished between bonus words and stigma words, i.e. words that probably occur together with important (e.g. the word form significant) or unimportant information. His idea of using key-words, i.e. words which occur significantly frequently in the document, is still one of the core heuristics of today's summarizers. With large linguistic corpora available today, the tf–idf value which originated in information retrieval, can be successfully applied to identify the key words of a text: If for example the word cat occurs significantly more often in the text to be summarized (TF = "term frequency") than in the corpus (IDF means "inverse document frequency"; here the corpus is meant by document), then cat is likely to be an important word of the text; the text may in fact be a text about cats.
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Large language model

A large language model (LLM) is a neural network trained on a vast amount of text for natural language processing tasks, especially language generation. LLMs can typically generate, summarize, translate and analyze text in many contexts, and are a foundational technology behind modern chatbots. Biased or inaccurate training data can make an LLM's output less reliable. As of 2026, the most capable LLMs are based on transformer architectures, which, according to the 2017 paper "Attention Is All You Need", can be more efficient and parallelizable than earlier statistical and recurrent neural network models. Benchmark evaluations for LLMs attempt to measure model reasoning, factual accuracy, alignment, and safety. == History == Before the emergence of transformer-based models in 2017, some language models were considered large relative to the computational and data constraints of their time. In the early 1990s, IBM's statistical models pioneered word alignment techniques for machine translation, laying the groundwork for corpus-based language modeling. In 2001, a smoothed n-gram model, such as those employing Kneser–Ney smoothing, trained on 300 million words, achieved state-of-the-art perplexity on benchmark tests. During the 2000s, with the rise of widespread internet access, researchers began compiling massive text datasets from the web ("web as corpus") to train statistical language models. Moving beyond n-gram models, researchers started in 2000 to use neural networks as language models. Following the breakthrough of deep neural networks in image classification around 2012, similar architectures were adapted for language tasks. This shift was marked by the development of word embeddings (e.g., Word2Vec by Mikolov in 2013) and sequence-to-sequence (seq2seq) models using LSTM. In 2016, Google transitioned its translation service to neural machine translation (NMT), replacing statistical phrase-based models with deep recurrent neural networks. These early NMT systems used LSTM-based encoder-decoder architectures, as they preceded the invention of transformers. At the 2017 NeurIPS conference, Google researchers introduced the transformer architecture in their landmark paper "Attention Is All You Need". This paper's goal was to improve upon 2014 seq2seq technology, and was based mainly on the attention mechanism developed by Bahdanau et al. in 2014. The following year in 2018, BERT was introduced and quickly became "ubiquitous". Though the original transformer has both encoder and decoder blocks, BERT is an encoder-only model. Academic and research usage of BERT began to decline in 2023, following rapid improvements in the abilities of decoder-only models (such as GPT) to solve tasks via prompting. Although decoder-only GPT-1 was introduced in 2018, it was GPT-2 in 2019 that caught widespread attention because OpenAI claimed to have initially deemed it too powerful to release publicly, out of fear of malicious use. GPT-3 in 2020 went a step further and as of 2025 is available only via API with no offering of downloading the model to execute locally. But it was the consumer-facing chatbot ChatGPT in late 2022 that received extensive media coverage and public attention by 2023. The 2023 GPT-4 was praised for its increased accuracy and as a "holy grail" for its multimodal capabilities. OpenAI did not reveal the high-level architecture and the number of parameters of GPT-4. The release of ChatGPT led to an uptick in LLM usage across several research subfields of computer science, including robotics, software engineering, and societal impact work. In 2024, OpenAI released the reasoning model OpenAI o1, which generates long chains of thought before returning a final answer. Many LLMs with parameter counts comparable to those of OpenAI's GPT series have been developed. Since 2022, weights-available models have been gaining popularity, especially at first with BLOOM and LLaMA, though both have restrictions on usage and deployment. Mistral AI's open-weight models Mistral 7B and Mixtral 8x7B have a more permissive Apache License. In January 2025, DeepSeek released DeepSeek R1, a 671-billion-parameter open-weight model that performs comparably to OpenAI o1 but at a much lower price per token for users. Since 2023, many LLMs have been trained to be multimodal, having the ability to also process or generate other types of data, such as images, audio, or 3D meshes. Open-weight LLMs have become more influential since 2023. Per Vake et al. (2025), community-driven contributions to open-weight models improve their efficiency and performance via collaborative platforms such as Hugging Face. == Dataset preprocessing == === Tokenization === As machine learning algorithms process numbers rather than text, the text must be converted to numbers. In the first step, a vocabulary is decided upon, then integer indices are arbitrarily but uniquely assigned to each vocabulary entry, and finally, an embedding is associated with the integer index. Algorithms include byte-pair encoding (BPE) and WordPiece. There are also special tokens serving as control characters, such as [MASK] for masked-out token (as used in BERT), and [UNK] ("unknown") for characters not appearing in the vocabulary. Also, some special symbols are used to denote special text formatting. For example, "Ġ" denotes a preceding whitespace in RoBERTa and GPT and "##" denotes continuation of a preceding word in BERT. For example, the BPE tokenizer used by the legacy version of GPT-3 would split tokenizer: texts -> series of numerical "tokens" as Tokenization also compresses the datasets. Because LLMs generally require input to be an array that is not jagged, the shorter texts must be "padded" until they match the length of the longest one. ==== Byte-pair encoding ==== As an example, consider a tokenizer based on byte-pair encoding. In the first step, all unique characters (including blanks and punctuation marks) are treated as an initial set of n-grams (i.e. initial set of uni-grams). Successively the most frequent pair of adjacent characters is merged into a bi-gram and all instances of the pair are replaced by it. All occurrences of adjacent pairs of (previously merged) n-grams that most frequently occur together are then again merged into even lengthier n-gram, until a vocabulary of prescribed size is obtained. After a tokenizer is trained, any text can be tokenized by it, as long as it does not contain characters not appearing in the initial-set of uni-grams. === Dataset cleaning === In the context of training LLMs, datasets are typically cleaned by removing low-quality, duplicated, or toxic data. Cleaned datasets can increase training efficiency and lead to improved downstream performance. A trained LLM can be used to clean datasets for training a further LLM. With the increasing proportion of LLM-generated content on the web, data cleaning in the future may include filtering out such content. LLM-generated content can pose a problem if the content is similar to human text (making filtering difficult) but of lower quality (degrading performance of models trained on it). === Synthetic data === Training of largest language models might need more linguistic data than naturally available, or that the naturally occurring data is of insufficient quality. In these cases, synthetic data might be used. == Training == An LLM is a type of foundation model (large X model) trained on language. LLMs can be trained in different ways. In particular, GPT models are first pretrained to predict the next word on a large amount of data, before being fine-tuned. === Cost === Substantial infrastructure is necessary for training the largest models. The tendency towards larger models is visible in the list of large language models. For example, the training of GPT-2 (i.e. a 1.5-billion-parameter model) in 2019 cost $50,000, while training of the PaLM (i.e. a 540-billion-parameter model) in 2022 cost $8 million, and Megatron-Turing NLG 530B (in 2021) cost around $11 million. The qualifier "large" in "large language model" is inherently vague, as there is no definitive threshold for the number of parameters required to qualify as "large". === Fine-tuning === Before being fine-tuned, most LLMs are next-token predictors. The fine-tuning shapes the LLM's behavior via techniques like reinforcement learning from human feedback (RLHF) or constitutional AI. Instruction fine-tuning is a form of supervised learning used to teach LLMs to follow user instructions. In 2022, OpenAI demonstrated InstructGPT, a version of GPT-3 similarly fine-tuned to follow instructions. Reinforcement learning from human feedback (RLHF) involves training a reward model to predict which text humans prefer. Then, the LLM can be fine-tuned through reinforcement learning to better satisfy this reward model. Since humans typically prefer truthful, helpful and harmless answers, RLHF favors such answers. == Architecture == LLMs are generally based on the tra
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Apache OpenNLP

The Apache OpenNLP library is a machine learning based toolkit for the processing of natural language text. It supports the most common NLP tasks, such as language detection, tokenization, sentence segmentation, part-of-speech tagging, named entity extraction, chunking, parsing and coreference resolution. These tasks are usually required to build more advanced text processing services.
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Render layers

When creating computer-generated imagery, final scenes appearing in movies and television productions are usually produced by rendering more than one "layer" or "pass," which are multiple images designed to be put together through digital compositing to form a completed frame. Rendering in passes is based on a traditions in motion control photography which predate CGI. As an example, for a visual effects shot, a camera could be programmed to move past a physical model of a spaceship in one pass to film the fully lit beauty pass of the ship, and then to repeat exactly the same camera move passing the ship again to photograph additional elements such as the illuminated windows in the ship or its thrusters. Once all of the passes were filmed, they could then be optically printed together to form a completed shot. The terms render layers and render passes are sometimes used interchangeably. However, rendering in layers refers specifically to separating different objects into separate images, such as a layer each for foreground characters, sets, distant landscape, and sky. On the other hand, rendering in passes refers to separating out different aspects of the scene, such as shadows, highlights, or reflections, into separate images.
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GeneRIF

A GeneRIF or Gene Reference Into Function is a short (255 characters or fewer) statement about the function of a gene. GeneRIFs provide a simple mechanism for allowing scientists to add to the functional annotation of genes described in the Entrez Gene database. In practice, function is constructed quite broadly. For example, there are GeneRIFs that discuss the role of a gene in a disease, GeneRIFs that point the viewer towards a review article about the gene, and GeneRIFs that discuss the structure of a gene. However, the stated intent is for GeneRIFs to be about gene function. Currently over half a million geneRIFs have been created for genes from almost 1000 different species. GeneRIFs are always associated with specific entries in the Entrez Gene database. Each GeneRIF has a pointer to the PubMed ID (a type of document identifier) of a scientific publication that provides evidence for the statement made by the GeneRIF. GeneRIFs are often extracted directly from the document that is identified by the PubMed ID, very frequently from its title or from its final sentence. GeneRIFs are usually produced by NCBI indexers, but anyone may submit a GeneRIF. To be processed, a valid Gene ID must exist for the specific gene, or the Gene staff must have assigned an overall Gene ID to the species. The latter case is implemented via records in Gene with the symbol NEWENTRY. Once the Gene ID is identified, only three types of information are required to complete a submission: a concise phrase describing a function or functions (less than 255 characters in length, preferably more than a restatement of the title of the paper); a published paper describing that function, implemented by supplying the PubMed ID of a citation in PubMed; a valid e-mail address (which will remain confidential). == Example == Here are some GeneRIFs taken from Entrez Gene for GeneID 7157, the human gene TP53. The PubMed document identifiers have been omitted from the examples. Note the wide variability with respect to the presence or absence of punctuation and of sentence-initial capital letters. p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. GeneRIFs are an unusual type of textual genre, and they have recently been the subject of a number of articles from the natural language processing community.
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Deep learning in photoacoustic imaging

Photoacoustic imaging (PA) is based on the photoacoustic effect, in which optical absorption causes a rise in temperature, which causes a subsequent rise in pressure via thermo-elastic expansion. This pressure rise propagates through the tissue and is sensed via ultrasonic transducers. Due to the proportionality between the optical absorption, the rise in temperature, and the rise in pressure, the ultrasound pressure wave signal can be used to quantify the original optical energy deposition within the tissue. Photoacoustic imaging has applications of deep learning in both photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM). PACT utilizes wide-field optical excitation and an array of unfocused ultrasound transducers. Similar to other computed tomography methods, the sample is imaged at multiple view angles, which are then used to perform an inverse reconstruction algorithm based on the detection geometry (typically through universal backprojection, modified delay-and-sum, or time reversal ) to elicit the initial pressure distribution within the tissue. PAM on the other hand uses focused ultrasound detection combined with weakly focused optical excitation (acoustic resolution PAM or AR-PAM) or tightly focused optical excitation (optical resolution PAM or OR-PAM). PAM typically captures images point-by-point via a mechanical raster scanning pattern. At each scanned point, the acoustic time-of-flight provides axial resolution while the acoustic focusing yields lateral resolution. == Applications of deep learning in PACT == The first application of deep learning in PACT was by Reiter et al. in which a deep neural network was trained to learn spatial impulse responses and locate photoacoustic point sources. The resulting mean axial and lateral point location errors on 2,412 of their randomly selected test images were 0.28 mm and 0.37 mm respectively. After this initial implementation, the applications of deep learning in PACT have branched out primarily into removing artifacts from acoustic reflections, sparse sampling, limited-view, and limited-bandwidth. There has also been some recent work in PACT toward using deep learning for wavefront localization. There have been networks based on fusion of information from two different reconstructions to improve the reconstruction using deep learning fusion based networks. === Using deep learning to locate photoacoustic point sources === Traditional photoacoustic beamforming techniques modeled photoacoustic wave propagation by using detector array geometry and the time-of-flight to account for differences in the PA signal arrival time. However, this technique failed to account for reverberant acoustic signals caused by acoustic reflection, resulting in acoustic reflection artifacts that corrupt the true photoacoustic point source location information. In Reiter et al., a convolutional neural network (similar to a simple VGG-16 style architecture) was used that took pre-beamformed photoacoustic data as input and outputted a classification result specifying the 2-D point source location. ==== Deep learning for PA wavefront localization ==== Johnstonbaugh et al. was able to localize the source of photoacoustic wavefronts with a deep neural network. The network used was an encoder-decoder style convolutional neural network. The encoder-decoder network was made of residual convolution, upsampling, and high field-of-view convolution modules. A Nyquist convolution layer and differentiable spatial-to-numerical transform layer were also used within the architecture. Simulated PA wavefronts served as the input for training the model. To create the wavefronts, the forward simulation of light propagation was done with the NIRFast toolbox and the light-diffusion approximation, while the forward simulation of sound propagation was done with the K-Wave toolbox. The simulated wavefronts were subjected to different scattering mediums and Gaussian noise. The output for the network was an artifact free heat map of the targets axial and lateral position. The network had a mean error rate of less than 30 microns when localizing target below 40 mm and had a mean error rate of 1.06 mm for localizing targets between 40 mm and 60 mm. With a slight modification to the network, the model was able to accommodate multi target localization. A validation experiment was performed in which pencil lead was submerged into an intralipid solution at a depth of 32 mm. The network was able to localize the lead's position when the solution had a reduced scattering coefficient of 0, 5, 10, and 15 cm−1. The results of the network show improvements over standard delay-and-sum or frequency-domain beamforming algorithms and Johnstonbaugh proposes that this technology could be used for optical wavefront shaping, circulating melanoma cell detection, and real-time vascular surgeries. === Removing acoustic reflection artifacts (in the presence of multiple sources and channel noise) === Building on the work of Reiter et al., Allman et al. utilized a full VGG-16 architecture to locate point sources and remove reflection artifacts within raw photoacoustic channel data (in the presence of multiple sources and channel noise). This utilization of deep learning trained on simulated data produced in the MATLAB k-wave library, and then later reaffirmed their results on experimental data. === Ill-posed PACT reconstruction === In PACT, tomographic reconstruction is performed, in which the projections from multiple solid angles are combined to form an image. When reconstruction methods like filtered backprojection or time reversal, are ill-posed inverse problems due to sampling under the Nyquist-Shannon's sampling requirement or with limited-bandwidth/view, the resulting reconstruction contains image artifacts. Traditionally these artifacts were removed with slow iterative methods like total variation minimization, but the advent of deep learning approaches has opened a new avenue that utilizes a priori knowledge from network training to remove artifacts. In the deep learning methods that seek to remove these sparse sampling, limited-bandwidth, and limited-view artifacts, the typical workflow involves first performing the ill-posed reconstruction technique to transform the pre-beamformed data into a 2-D representation of the initial pressure distribution that contains artifacts. Then, a convolutional neural network (CNN) is trained to remove the artifacts, in order to produce an artifact-free representation of the ground truth initial pressure distribution. ==== Using deep learning to remove sparse sampling artifacts ==== When the density of uniform tomographic view angles is under what is prescribed by the Nyquist-Shannon's sampling theorem, it is said that the imaging system is performing sparse sampling. Sparse sampling typically occurs as a way of keeping production costs low and improving image acquisition speed. The typical network architectures used to remove these sparse sampling artifacts are U-net and Fully Dense (FD) U-net. Both of these architectures contain a compression and decompression phase. The compression phase learns to compress the image to a latent representation that lacks the imaging artifacts and other details. The decompression phase then combines with information passed by the residual connections in order to add back image details without adding in the details associated with the artifacts. FD U-net modifies the original U-net architecture by including dense blocks that allow layers to utilize information learned by previous layers within the dense block. Another technique was proposed using a simple CNN based architecture for removal of artifacts and improving the k-wave image reconstruction. ==== Removing limited-view artifacts with deep learning ==== When a region of partial solid angles are not captured, generally due to geometric limitations, the image acquisition is said to have limited-view. As illustrated by the experiments of Davoudi et al., limited-view corruptions can be directly observed as missing information in the frequency domain of the reconstructed image. Limited-view, similar to sparse sampling, makes the initial reconstruction algorithm ill-posed. Prior to deep learning, the limited-view problem was addressed with complex hardware such as acoustic deflectors and full ring-shaped transducer arrays, as well as solutions like compressed sensing, weighted factor, and iterative filtered backprojection. The result of this ill-posed reconstruction is imaging artifacts that can be removed by CNNs. The deep learning algorithms used to remove limited-view artifacts include U-net and FD U-net, as well as generative adversarial networks (GANs) and volumetric versions of U-net. One GAN implementation of note improved upon U-net by using U-net as a generator and VGG as a discriminator, with the Wasserstein metric and gradient penalty to stabilize training (WGAN-GP). ==== Pixel-wise interpolation
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