AI Data Center Map

AI Data Center Map — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

  • Aldus PhotoStyler

    Aldus PhotoStyler

    Aldus PhotoStyler was a graphics software program developed by the Taiwanese company Ulead. Released in June 1991 as the first 24 bit image editor for Windows, it was bought the same year by the Aldus Prepress group. Its main competition was Adobe Photoshop. Version 2.0 (late 1993) introduced a new user interface and improved color calibration. PhotoStyler SE - lacking some features of the version 2.0 - was bundled with scanners like HP ScanJet. The product disappeared from the Adobe product line after Adobe acquired Aldus in 1994.

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  • Mean squared prediction error

    Mean squared prediction error

    In statistics the mean squared prediction error (MSPE), also known as mean squared error of the predictions, of a smoothing, curve fitting, or regression procedure is the expected value of the squared prediction errors (PE), the square difference between the fitted values implied by the predictive function g ^ {\displaystyle {\widehat {g}}} and the values of the (unobservable) true value g. It is an inverse measure of the explanatory power of g ^ , {\displaystyle {\widehat {g}},} and can be used in the process of cross-validation of an estimated model. Knowledge of g would be required in order to calculate the MSPE exactly; in practice, MSPE is estimated. == Formulation == If the smoothing or fitting procedure has projection matrix (i.e., hat matrix) L, which maps the observed values vector y {\displaystyle y} to predicted values vector y ^ = L y , {\displaystyle {\hat {y}}=Ly,} then PE and MSPE are formulated as: P E i = g ( x i ) − g ^ ( x i ) , {\displaystyle \operatorname {PE_{i}} =g(x_{i})-{\widehat {g}}(x_{i}),} MSPE = E ⁡ [ PE i 2 ] = ∑ i = 1 n PE i 2 ⁡ / n . {\displaystyle \operatorname {MSPE} =\operatorname {E} \left[\operatorname {PE} _{i}^{2}\right]=\sum _{i=1}^{n}\operatorname {PE} _{i}^{2}/n.} The MSPE can be decomposed into two terms: the squared bias (mean error) of the fitted values and the variance of the fitted values: MSPE = ME 2 + VAR , {\displaystyle \operatorname {MSPE} =\operatorname {ME} ^{2}+\operatorname {VAR} ,} ME = E ⁡ [ g ^ ( x i ) − g ( x i ) ] {\displaystyle \operatorname {ME} =\operatorname {E} \left[{\widehat {g}}(x_{i})-g(x_{i})\right]} VAR = E ⁡ [ ( g ^ ( x i ) − E ⁡ [ g ( x i ) ] ) 2 ] . {\displaystyle \operatorname {VAR} =\operatorname {E} \left[\left({\widehat {g}}(x_{i})-\operatorname {E} \left[{g}(x_{i})\right]\right)^{2}\right].} The quantity SSPE=nMSPE is called sum squared prediction error. The root mean squared prediction error is the square root of MSPE: RMSPE=√MSPE. == Computation of MSPE over out-of-sample data == The mean squared prediction error can be computed exactly in two contexts. First, with a data sample of length n, the data analyst may run the regression over only q of the data points (with q < n), holding back the other n – q data points with the specific purpose of using them to compute the estimated model’s MSPE out of sample (i.e., not using data that were used in the model estimation process). Since the regression process is tailored to the q in-sample points, normally the in-sample MSPE will be smaller than the out-of-sample one computed over the n – q held-back points. If the increase in the MSPE out of sample compared to in sample is relatively slight, that results in the model being viewed favorably. And if two models are to be compared, the one with the lower MSPE over the n – q out-of-sample data points is viewed more favorably, regardless of the models’ relative in-sample performances. The out-of-sample MSPE in this context is exact for the out-of-sample data points that it was computed over, but is merely an estimate of the model’s MSPE for the mostly unobserved population from which the data were drawn. Second, as time goes on more data may become available to the data analyst, and then the MSPE can be computed over these new data. == Estimation of MSPE over the population == When the model has been estimated over all available data with none held back, the MSPE of the model over the entire population of mostly unobserved data can be estimated as follows. For the model y i = g ( x i ) + σ ε i {\displaystyle y_{i}=g(x_{i})+\sigma \varepsilon _{i}} where ε i ∼ N ( 0 , 1 ) {\displaystyle \varepsilon _{i}\sim {\mathcal {N}}(0,1)} , one may write n ⋅ MSPE ⁡ ( L ) = g T ( I − L ) T ( I − L ) g + σ 2 tr ⁡ [ L T L ] . {\displaystyle n\cdot \operatorname {MSPE} (L)=g^{\text{T}}(I-L)^{\text{T}}(I-L)g+\sigma ^{2}\operatorname {tr} \left[L^{\text{T}}L\right].} Using in-sample data values, the first term on the right side is equivalent to ∑ i = 1 n ( E ⁡ [ g ( x i ) − g ^ ( x i ) ] ) 2 = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 tr ⁡ [ ( I − L ) T ( I − L ) ] . {\displaystyle \sum _{i=1}^{n}\left(\operatorname {E} \left[g(x_{i})-{\widehat {g}}(x_{i})\right]\right)^{2}=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\operatorname {tr} \left[\left(I-L\right)^{T}\left(I-L\right)\right].} Thus, n ⋅ MSPE ⁡ ( L ) = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {MSPE} (L)=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\left(n-\operatorname {tr} \left[L\right]\right).} If σ 2 {\displaystyle \sigma ^{2}} is known or well-estimated by σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} , it becomes possible to estimate MSPE by n ⋅ M S P E ^ ⁡ ( L ) = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 − σ ^ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {\widehat {MSPE}} (L)=\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}-{\widehat {\sigma }}^{2}\left(n-\operatorname {tr} \left[L\right]\right).} Colin Mallows advocated this method in the construction of his model selection statistic Cp, which is a normalized version of the estimated MSPE: C p = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 σ ^ 2 − n + 2 p . {\displaystyle C_{p}={\frac {\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}}{{\widehat {\sigma }}^{2}}}-n+2p.} where p the number of estimated parameters p and σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} is computed from the version of the model that includes all possible regressors. That concludes this proof.

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  • Semidefinite embedding

    Semidefinite embedding

    Maximum Variance Unfolding (MVU), also known as Semidefinite Embedding (SDE), is an algorithm in computer science that uses semidefinite programming to perform non-linear dimensionality reduction of high-dimensional vectorial input data. It is motivated by the observation that kernel Principal Component Analysis (kPCA) does not reduce the data dimensionality, as it leverages the Kernel trick to non-linearly map the original data into an inner-product space. == Algorithm == MVU creates a mapping from the high dimensional input vectors to some low dimensional Euclidean vector space in the following steps: A neighbourhood graph is created. Each input is connected with its k-nearest input vectors (according to Euclidean distance metric) and all k-nearest neighbors are connected with each other. If the data is sampled well enough, the resulting graph is a discrete approximation of the underlying manifold. The neighbourhood graph is "unfolded" with the help of semidefinite programming. Instead of learning the output vectors directly, the semidefinite programming aims to find an inner product matrix that maximizes the pairwise distances between any two inputs that are not connected in the neighbourhood graph while preserving the nearest neighbors distances. The low-dimensional embedding is finally obtained by application of multidimensional scaling on the learned inner product matrix. The steps of applying semidefinite programming followed by a linear dimensionality reduction step to recover a low-dimensional embedding into a Euclidean space were first proposed by Linial, London, and Rabinovich. == Optimization formulation == Let X {\displaystyle X\,\!} be the original input and Y {\displaystyle Y\,\!} be the embedding. If i , j {\displaystyle i,j\,\!} are two neighbors, then the local isometry constraint that needs to be satisfied is: | X i − X j | 2 = | Y i − Y j | 2 {\displaystyle |X_{i}-X_{j}|^{2}=|Y_{i}-Y_{j}|^{2}\,\!} Let G , K {\displaystyle G,K\,\!} be the Gram matrices of X {\displaystyle X\,\!} and Y {\displaystyle Y\,\!} (i.e.: G i j = X i ⋅ X j , K i j = Y i ⋅ Y j {\displaystyle G_{ij}=X_{i}\cdot X_{j},K_{ij}=Y_{i}\cdot Y_{j}\,\!} ). We can express the above constraint for every neighbor points i , j {\displaystyle i,j\,\!} in term of G , K {\displaystyle G,K\,\!} : G i i + G j j − G i j − G j i = K i i + K j j − K i j − K j i {\displaystyle G_{ii}+G_{jj}-G_{ij}-G_{ji}=K_{ii}+K_{jj}-K_{ij}-K_{ji}\,\!} In addition, we also want to constrain the embedding Y {\displaystyle Y\,\!} to center at the origin: 0 = | ∑ i Y i | 2 ⇔ ( ∑ i Y i ) ⋅ ( ∑ i Y i ) ⇔ ∑ i , j Y i ⋅ Y j ⇔ ∑ i , j K i j {\displaystyle 0=|\sum _{i}Y_{i}|^{2}\Leftrightarrow (\sum _{i}Y_{i})\cdot (\sum _{i}Y_{i})\Leftrightarrow \sum _{i,j}Y_{i}\cdot Y_{j}\Leftrightarrow \sum _{i,j}K_{ij}} As described above, except the distances of neighbor points are preserved, the algorithm aims to maximize the pairwise distance of every pair of points. The objective function to be maximized is: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 {\displaystyle T(Y)={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}} Intuitively, maximizing the function above is equivalent to pulling the points as far away from each other as possible and therefore "unfold" the manifold. The local isometry constraint Let τ = m a x { η i j | Y i − Y j | 2 } {\displaystyle \tau =max\{\eta _{ij}|Y_{i}-Y_{j}|^{2}\}\,\!} where η i j := { 1 if i is a neighbour of j 0 otherwise . {\displaystyle \eta _{ij}:={\begin{cases}1&{\mbox{if}}\ i{\mbox{ is a neighbour of }}j\\0&{\mbox{otherwise}}.\end{cases}}} prevents the objective function from diverging (going to infinity). Since the graph has N points, the distance between any two points | Y i − Y j | 2 ≤ N τ {\displaystyle |Y_{i}-Y_{j}|^{2}\leq N\tau \,\!} . We can then bound the objective function as follows: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 ≤ 1 2 N ∑ i , j ( N τ ) 2 = N 3 τ 2 2 {\displaystyle T(Y)={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}\leq {\dfrac {1}{2N}}\sum _{i,j}(N\tau )^{2}={\dfrac {N^{3}\tau ^{2}}{2}}\,\!} The objective function can be rewritten purely in the form of the Gram matrix: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 = 1 2 N ∑ i , j ( Y i 2 + Y j 2 − Y i ⋅ Y j − Y j ⋅ Y i ) = 1 2 N ( ∑ i , j Y i 2 + ∑ i , j Y j 2 − ∑ i , j Y i ⋅ Y j − ∑ i , j Y j ⋅ Y i ) = 1 2 N ( ∑ i , j Y i 2 + ∑ i , j Y j 2 − 0 − 0 ) = 1 N ( ∑ i Y i 2 ) = 1 N ( T r ( K ) ) {\displaystyle {\begin{aligned}T(Y)&{}={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}\\&{}={\dfrac {1}{2N}}\sum _{i,j}(Y_{i}^{2}+Y_{j}^{2}-Y_{i}\cdot Y_{j}-Y_{j}\cdot Y_{i})\\&{}={\dfrac {1}{2N}}(\sum _{i,j}Y_{i}^{2}+\sum _{i,j}Y_{j}^{2}-\sum _{i,j}Y_{i}\cdot Y_{j}-\sum _{i,j}Y_{j}\cdot Y_{i})\\&{}={\dfrac {1}{2N}}(\sum _{i,j}Y_{i}^{2}+\sum _{i,j}Y_{j}^{2}-0-0)\\&{}={\dfrac {1}{N}}(\sum _{i}Y_{i}^{2})={\dfrac {1}{N}}(Tr(K))\\\end{aligned}}\,\!} Finally, the optimization can be formulated as: Maximize T r ( K ) subject to K ⪰ 0 , ∑ i j K i j = 0 and G i i + G j j − G i j − G j i = K i i + K j j − K i j − K j i , ∀ i , j where η i j = 1 , {\displaystyle {\begin{aligned}&{\text{Maximize}}&&Tr(\mathbf {K} )\\&{\text{subject to}}&&\mathbf {K} \succeq 0,\sum _{ij}\mathbf {K} _{ij}=0\\&{\text{and}}&&G_{ii}+G_{jj}-G_{ij}-G_{ji}=K_{ii}+K_{jj}-K_{ij}-K_{ji},\forall i,j{\mbox{ where }}\eta _{ij}=1,\end{aligned}}} After the Gram matrix K {\displaystyle K\,\!} is learned by semidefinite programming, the output Y {\displaystyle Y\,\!} can be obtained via Cholesky decomposition. In particular, the Gram matrix can be written as K i j = ∑ α = 1 N ( λ α V α i V α j ) {\displaystyle K_{ij}=\sum _{\alpha =1}^{N}(\lambda _{\alpha }V_{\alpha i}V_{\alpha j})\,\!} where V α i {\displaystyle V_{\alpha i}\,\!} is the i-th element of eigenvector V α {\displaystyle V_{\alpha }\,\!} of the eigenvalue λ α {\displaystyle \lambda _{\alpha }\,\!} . It follows that the α {\displaystyle \alpha \,\!} -th element of the output Y i {\displaystyle Y_{i}\,\!} is λ α V α i {\displaystyle {\sqrt {\lambda _{\alpha }}}V_{\alpha i}\,\!} .

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  • Multilinear principal component analysis

    Multilinear principal component analysis

    Multilinear principal component analysis (MPCA) is a multilinear extension of principal component analysis (PCA) that is used to analyze M-way arrays, also informally referred to as "data tensors". M-way arrays may be modeled by linear tensor models, such as CANDECOMP/Parafac, or by multilinear tensor models, such as multilinear principal component analysis (MPCA) or multilinear (tensor) independent component analysis (MICA). In 2005, Vasilescu and Terzopoulos introduced the Multilinear PCA terminology as a way to better differentiate between multilinear data models that employed 2nd order statistics versus higher order statistics to compute a set of independent components for each mode, such as Multilinear ICA Multilinear PCA may be applied to compute the causal factors of data formation, or as signal processing tool on data tensors whose individual observation have either been vectorized, or whose observations are treated as a collection of column/row observations, an "observation as a matrix", and concatenated into a data tensor. The latter approach is suitable for compression and reducing redundancy in the rows, columns and fibers that are unrelated to the causal factors of data formation. Vasilescu and Terzopoulos in their paper "TensorFaces" introduced the M-mode SVD algorithm which are algorithms misidentified in the literature as the HOSVD or the Tucker which employ the power method or gradient descent, respectively. Vasilescu and Terzopoulos framed the data analysis, recognition and synthesis problems as multilinear tensor problems. Data is viewed as the compositional consequence of several causal factors, that are well suited for multi-modal tensor factor analysis. The power of the tensor framework was showcased by analyzing human motion joint angles, facial images or textures in the following papers: Human Motion Signatures (CVPR 2001, ICPR 2002), face recognition – TensorFaces, (ECCV 2002, CVPR 2003, etc.) and computer graphics – TensorTextures (Siggraph 2004). == The algorithm == The MPCA solution follows the alternating least square (ALS) approach. It is iterative in nature. As in PCA, MPCA works on centered data. Centering is a little more complicated for tensors, and it is problem dependent. == Feature selection == MPCA features: Supervised MPCA is employed in causal factor analysis that facilitates object recognition while a semi-supervised MPCA feature selection is employed in visualization tasks. == Extensions == Various extension of MPCA: Robust MPCA (RMPCA) Multi-Tensor Factorization, that also finds the number of components automatically (MTF)

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  • Semantic analytics

    Semantic analytics

    Semantic analytics, also termed semantic relatedness, is the use of ontologies to analyze content in web resources. This field of research combines text analytics and Semantic Web technologies like RDF. Semantic analytics measures the relatedness of different ontological concepts. Some academic research groups that have active project in this area include Kno.e.sis Center at Wright State University among others. == History == An important milestone in the beginning of semantic analytics occurred in 1996, although the historical progression of these algorithms is largely subjective. In his seminal study publication, Philip Resnik established that computers have the capacity to emulate human judgement. Spanning the publications of multiple journals, improvements to the accuracy of general semantic analytic computations all claimed to revolutionize the field. However, the lack of a standard terminology throughout the late 1990s was the cause of much miscommunication. This prompted Budanitsky & Hirst to standardize the subject in 2006 with a summary that also set a framework for modern spelling and grammar analysis. In the early days of semantic analytics, obtaining a large enough reliable knowledge bases was difficult. In 2006, Strube & Ponzetto demonstrated that Wikipedia could be used in semantic analytic calculations. The usage of a large knowledge base like Wikipedia allows for an increase in both the accuracy and applicability of semantic analytics. == Methods == Given the subjective nature of the field, different methods used in semantic analytics depend on the domain of application. No singular methods is considered correct, however one of the most generally effective and applicable method is explicit semantic analysis (ESA). ESA was developed by Evgeniy Gabrilovich and Shaul Markovitch in the late 2000s. It uses machine learning techniques to create a semantic interpreter, which extracts text fragments from articles into a sorted list. The fragments are sorted by how related they are to the surrounding text. Latent semantic analysis (LSA) is another common method that does not use ontologies, only considering the text in the input space. == Applications == Entity linking Ontology building / knowledge base population Search and query tasks Natural language processing Spoken dialog systems (e.g., Amazon Alexa, Google Assistant, Microsoft's Cortana) Artificial intelligence Knowledge management The application of semantic analysis methods generally streamlines organizational processes of any knowledge management system. Academic libraries often use a domain-specific application to create a more efficient organizational system. By classifying scientific publications using semantics and Wikipedia, researchers are helping people find resources faster. Search engines like Semantic Scholar provide organized access to millions of articles.

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  • TabPFN

    TabPFN

    TabPFN (Tabular Prior-data Fitted Network) is a machine learning model for tabular datasets proposed in 2022. It uses a transformer architecture. It is intended for supervised classification and regression analysis on tabular datasets, particularly focusing on small- to medium-sized datasets. The latest version, TabPFN-3, was released in May 2026 and supports datasets with up to one million rows and 200 features. == History == TabPFN was first introduced in a 2022 pre-print and presented at ICLR 2023. TabPFN v2 was published in 2025 in Nature by Hollmann and co-authors. The source code is published on GitHub under a modified Apache License and on PyPi. Writing for ICLR blogs, McCarter states that the model has attracted attention due to its performance on small dataset benchmarks. TabPFN v2.5 was released on November 6, 2025. TabPFN-3 was released on May 12, 2026. Prior Labs, founded in 2024, aims to commercialize TabPFN. As of April 2026, the open-source TabPFN repository had more than 6,000 stars on GitHub. == Overview and pre-training == TabPFN supports classification, regression and generative tasks. It leverages "Prior-Data Fitted Networks" models to model tabular data. By using a transformer pre-trained on synthetic tabular datasets, TabPFN avoids benchmark contamination and costs of curating real-world data. TabPFN v2 was pre-trained on approximately 130 million such datasets. Synthetic datasets are generated using causal models or Bayesian neural networks; this can include simulating missing values, imbalanced data, and noise. Random inputs are passed through these models to generate outputs, with a bias towards simpler causal structures. During pre-training, TabPFN predicts the masked target values of new data points given training data points and their known targets, effectively learning a generic learning algorithm that is executed by running a neural network forward pass. The new dataset is then processed in a single forward pass without retraining. The model's transformer encoder processes features and labels by alternating attention across rows and columns. TabPFN v2 handles numerical and categorical features, missing values, and supports tasks like regression and synthetic data generation, while TabPFN-2.5 scales this approach to datasets with up to 50,000 rows and 2,000 features. TabPFN-3 introduced a redesigned architecture with row-compression, an attention-based many-class decoder, native missing-value handling, and inference optimizations such as row chunking and a reduced key-value cache, with benchmark-validated regimes of up to 1 million rows with 200 features, 100,000 rows with 2,000 features, or 1,000 rows with 20,000 features. Since TabPFN is pre-trained, in contrast to other deep learning methods, it does not require costly hyperparameter optimization. == Research == TabPFN is the subject of on-going research. Applications for TabPFN have been investigated for domains such as chemoproteomics, insurance risk classification, and metagenomics. In clinical research, TabPFN was used in a study on the early detection of pancreatic cancer from blood samples, where it was combined with metabolomic data and reported high diagnostic performance. == Applications == TabPFN has been used in industrial and biomedical contexts. Hitachi Ltd. has been reported to use the model for predictive maintenance in rail networks, with its use described as helping to identify track issues earlier and reduce manual inspections. In the biomedical domain, Oxford Cancer Analytics has used TabPFN in the analysis of proteomic data in lung disease research. A 2025 ML Contests report noted that the winners of DrivenData's PREPARE challenge used TabPFN to generate features for gradient-boosted decision tree models. == Limitations == TabPFN has been criticized for its "one large neural network is all you need" approach to modeling problems. Further, its performance is limited in high-dimensional and large-scale datasets. == Scaling Mode == In late November 2025, Prior Labs introduced ‘‘Scaling Mode’’, an operating mode for TabPFN designed to remove the fixed upper bound on training set size. Earlier versions of TabPFN had been optimized and validated primarily for datasets of up to 100,000 rows, whereas Scaling Mode was reported to extend support to substantially larger datasets, with benchmarked experiments on datasets containing up to 10 million rows. According to Prior Labs, Scaling Mode preserves the existing TabPFN architecture, including its alternating row-attention and column-attention design, as well as the same feature-count limits as prior releases. Inference remains based on a single forward pass rather than dataset-specific gradient-descent training, while scalability is described as being constrained primarily by available compute and memory resources. Prior Labs reported benchmark results on an internal collection of datasets ranging from 1 million to 10 million rows across industry and scientific applications. In these benchmarks, Scaling Mode was compared with CatBoost, XGBoost, LightGBM, and TabPFN 2.5 using 50,000-row subsampling. The company stated that predictive performance improved monotonically with increasing training set size and that no diminishing returns from scaling were observed within the tested range. Prior Labs also announced the release through company and executive social media channels. TabPFN-3 later incorporated related scaling improvements, including row chunking and a reduced key-value cache, into the model architecture and inference pipeline.

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  • Crossover (evolutionary algorithm)

    Crossover (evolutionary algorithm)

    Crossover in evolutionary algorithms and evolutionary computation, also called recombination, is a genetic operator used to combine the genetic information of two parents to generate new offspring. It is one way to stochastically generate new solutions from an existing population, and is analogous to the crossover that happens during sexual reproduction in biology. New solutions can also be generated by cloning an existing solution, which is analogous to asexual reproduction. Newly generated solutions may be mutated before being added to the population. The aim of recombination is to transfer good characteristics from two different parents to one child. Different algorithms in evolutionary computation may use different data structures to store genetic information, and each genetic representation can be recombined with different crossover operators. Typical data structures that can be recombined with crossover are bit arrays, vectors of real numbers, or trees. The list of operators presented below is by no means complete and serves mainly as an exemplary illustration of this dyadic genetic operator type. More operators and more details can be found in the literature. == Crossover for binary arrays == Traditional genetic algorithms store genetic information in a chromosome represented by a bit array. Crossover methods for bit arrays are popular and an illustrative example of genetic recombination. === One-point crossover === A point on both parents' chromosomes is picked randomly, and designated a 'crossover point'. Bits to the right of that point are swapped between the two parent chromosomes. This results in two offspring, each carrying some genetic information from both parents. === Two-point and k-point crossover === In two-point crossover, two crossover points are picked randomly from the parent chromosomes. The bits in between the two points are swapped between the parent organisms. Two-point crossover is equivalent to performing two single-point crossovers with different crossover points. This strategy can be generalized to k-point crossover for any positive integer k, picking k crossover points. === Uniform crossover === In uniform crossover, typically, each bit is chosen from either parent with equal probability. Other mixing ratios are sometimes used, resulting in offspring which inherit more genetic information from one parent than the other. In a uniform crossover, we don’t divide the chromosome into segments, rather we treat each gene separately. In this, we essentially flip a coin for each chromosome to decide whether or not it will be included in the off-spring. == Crossover for integer or real-valued genomes == For the crossover operators presented above and for most other crossover operators for bit strings, it holds that they can also be applied accordingly to integer or real-valued genomes whose genes each consist of an integer or real-valued number. Instead of individual bits, integer or real-valued numbers are then simply copied into the child genome. The offspring lie on the remaining corners of the hyperbody spanned by the two parents P 1 = ( 1.5 , 6 , 8 ) {\displaystyle P_{1}=(1.5,6,8)} and P 2 = ( 7 , 2 , 1 ) {\displaystyle P_{2}=(7,2,1)} , as exemplified in the accompanying image for the three-dimensional case. === Discrete recombination === If the rules of the uniform crossover for bit strings are applied during the generation of the offspring, this is also called discrete recombination. === Intermediate recombination === In this recombination operator, the allele values of the child genome a i {\displaystyle a_{i}} are generated by mixing the alleles of the two parent genomes a i , P 1 {\displaystyle a_{i,P_{1}}} and a i , P 2 {\displaystyle a_{i,P_{2}}} : α i = α i , P 1 ⋅ β i + α i , P 2 ⋅ ( 1 − β i ) w i t h β i ∈ [ − d , 1 + d ] {\displaystyle \alpha _{i}=\alpha _{i,P_{1}}\cdot \beta _{i}+\alpha _{i,P_{2}}\cdot \left(1-\beta _{i}\right)\quad {\mathsf {with}}\quad \beta _{i}\in \left[-d,1+d\right]} randomly equally distributed per gene i {\displaystyle i} The choice of the interval [ − d , 1 + d ] {\displaystyle [-d,1+d]} causes that besides the interior of the hyperbody spanned by the allele values of the parent genes additionally a certain environment for the range of values of the offspring is in question. A value of 0.25 {\displaystyle 0.25} is recommended for d {\displaystyle d} to counteract the tendency to reduce the allele values that otherwise exists at d = 0 {\displaystyle d=0} . The adjacent figure shows for the two-dimensional case the range of possible new alleles of the two exemplary parents P 1 = ( 3 , 6 ) {\displaystyle P_{1}=(3,6)} and P 2 = ( 9 , 2 ) {\displaystyle P_{2}=(9,2)} in intermediate recombination. The offspring of discrete recombination C 1 {\displaystyle C_{1}} and C 2 {\displaystyle C_{2}} are also plotted. Intermediate recombination satisfies the arithmetic calculation of the allele values of the child genome required by virtual alphabet theory. Discrete and intermediate recombination are used as a standard in the evolution strategy. == Crossover for permutations == For combinatorial tasks, permutations are usually used that are specifically designed for genomes that are themselves permutations of a set. The underlying set is usually a subset of N {\displaystyle \mathbb {N} } or N 0 {\displaystyle \mathbb {N} _{0}} . If 1- or n-point or uniform crossover for integer genomes is used for such genomes, a child genome may contain some values twice and others may be missing. This can be remedied by genetic repair, e.g. by replacing the redundant genes in positional fidelity for missing ones from the other child genome. In order to avoid the generation of invalid offspring, special crossover operators for permutations have been developed which fulfill the basic requirements of such operators for permutations, namely that all elements of the initial permutation are also present in the new one and only the order is changed. It can be distinguished between combinatorial tasks, where all sequences are admissible, and those where there are constraints in the form of inadmissible partial sequences. A well-known representative of the first task type is the traveling salesman problem (TSP), where the goal is to visit a set of cities exactly once on the shortest tour. An example of the constrained task type is the scheduling of multiple workflows. Workflows involve sequence constraints on some of the individual work steps. For example, a thread cannot be cut until the corresponding hole has been drilled in a workpiece. Such problems are also called order-based permutations. In the following, two crossover operators are presented as examples, the partially mapped crossover (PMX) motivated by the TSP and the order crossover (OX1) designed for order-based permutations. A second offspring can be produced in each case by exchanging the parent chromosomes. === Partially mapped crossover (PMX) === The PMX operator was designed as a recombination operator for TSP like Problems. The explanation of the procedure is illustrated by an example: === Order crossover (OX1) === The order crossover goes back to Davis in its original form and is presented here in a slightly generalized version with more than two crossover points. It transfers information about the relative order from the second parent to the offspring. First, the number and position of the crossover points are determined randomly. The resulting gene sequences are then processed as described below: Among other things, order crossover is well suited for scheduling multiple workflows, when used in conjunction with 1- and n-point crossover. === Further crossover operators for permutations === Over time, a large number of crossover operators for permutations have been proposed, so the following list is only a small selection. For more information, the reader is referred to the literature. cycle crossover (CX) order-based crossover (OX2) position-based crossover (POS) edge recombination voting recombination (VR) alternating-positions crossover (AP) maximal preservative crossover (MPX) merge crossover (MX) sequential constructive crossover operator (SCX) The usual approach to solving TSP-like problems by genetic or, more generally, evolutionary algorithms, presented earlier, is either to repair illegal descendants or to adjust the operators appropriately so that illegal offspring do not arise in the first place. Alternatively, Riazi suggests the use of a double chromosome representation, which avoids illegal offspring.

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  • Online machine learning

    Online machine learning

    In computer science, online machine learning is a method of machine learning in which data becomes available in a sequential order and is used to update the best predictor for future data at each step, as opposed to batch learning techniques which generate the best predictor by learning on the entire training data set at once. Online learning is a common technique used in areas of machine learning where it is computationally infeasible to train over the entire dataset, requiring the need of out-of-core algorithms. It is also used in situations where it is necessary for the algorithm to dynamically adapt to new patterns in the data, or when the data itself is generated as a function of time, e.g., prediction of prices in the financial international markets. Online learning algorithms may be prone to catastrophic interference, a problem that can be addressed by incremental learning approaches. Online machine learning algorithms find applications in a wide variety of fields such as sponsored search to maximize ad revenue, portfolio optimization, shortest path prediction (with stochastic weights, e.g. traffic on roads for a maps application), spam filtering, real-time fraud detection, dynamic pricing for e-commerce, etc. There is also growing interest in usage of online learning paradigms for LLMs to enable continuous, real-time adaptation after the initial training. == Introduction == In the setting of supervised learning, a function of f : X → Y {\displaystyle f:X\to Y} is to be learned, where X {\displaystyle X} is thought of as a space of inputs and Y {\displaystyle Y} as a space of outputs, that predicts well on instances that are drawn from a joint probability distribution p ( x , y ) {\displaystyle p(x,y)} on X × Y {\displaystyle X\times Y} . In reality, the learner never knows the true distribution p ( x , y ) {\displaystyle p(x,y)} over instances. Instead, the learner usually has access to a training set of examples ( x 1 , y 1 ) , … , ( x n , y n ) {\displaystyle (x_{1},y_{1}),\ldots ,(x_{n},y_{n})} . In this setting, the loss function is given as V : Y × Y → R {\displaystyle V:Y\times Y\to \mathbb {R} } , such that V ( f ( x ) , y ) {\displaystyle V(f(x),y)} measures the difference between the predicted value f ( x ) {\displaystyle f(x)} and the true value y {\displaystyle y} . The ideal goal is to select a function f ∈ H {\displaystyle f\in {\mathcal {H}}} , where H {\displaystyle {\mathcal {H}}} is a space of functions called a hypothesis space, so that some notion of total loss is minimized. Depending on the type of model (statistical or adversarial), one can devise different notions of loss, which lead to different learning algorithms. == Statistical view of online learning == In statistical learning models, the training sample ( x i , y i ) {\displaystyle (x_{i},y_{i})} are assumed to have been drawn from the true distribution p ( x , y ) {\displaystyle p(x,y)} and the objective is to minimize the expected "risk" I [ f ] = E [ V ( f ( x ) , y ) ] = ∫ V ( f ( x ) , y ) d p ( x , y ) . {\displaystyle I[f]=\mathbb {E} [V(f(x),y)]=\int V(f(x),y)\,dp(x,y)\ .} A common paradigm in this situation is to estimate a function f ^ {\displaystyle {\hat {f}}} through empirical risk minimization or regularized empirical risk minimization (usually Tikhonov regularization). The choice of loss function here gives rise to several well-known learning algorithms such as regularized least squares and support vector machines. A purely online model in this category would learn based on just the new input ( x t + 1 , y t + 1 ) {\displaystyle (x_{t+1},y_{t+1})} , the current best predictor f t {\displaystyle f_{t}} and some extra stored information (which is usually expected to have storage requirements independent of training data size). For many formulations, for example nonlinear kernel methods, true online learning is not possible, though a form of hybrid online learning with recursive algorithms can be used where f t + 1 {\displaystyle f_{t+1}} is permitted to depend on f t {\displaystyle f_{t}} and all previous data points ( x 1 , y 1 ) , … , ( x t , y t ) {\displaystyle (x_{1},y_{1}),\ldots ,(x_{t},y_{t})} . In this case, the space requirements are no longer guaranteed to be constant since it requires storing all previous data points, but the solution may take less time to compute with the addition of a new data point, as compared to batch learning techniques. A common strategy to overcome the above issues is to learn using mini-batches, which process a small batch of b ≥ 1 {\displaystyle b\geq 1} data points at a time, this can be considered as pseudo-online learning for b {\displaystyle b} much smaller than the total number of training points. Mini-batch techniques are used with repeated passing over the training data to obtain optimized out-of-core versions of machine learning algorithms, for example, stochastic gradient descent. When combined with backpropagation, this is currently the de facto training method for training artificial neural networks. === Example: linear least squares === The simple example of linear least squares is used to explain a variety of ideas in online learning. The ideas are general enough to be applied to other settings, for example, with other convex loss functions. === Batch learning === Consider the setting of supervised learning with f {\displaystyle f} being a linear function to be learned: f ( x j ) = ⟨ w , x j ⟩ = w ⋅ x j {\displaystyle f(x_{j})=\langle w,x_{j}\rangle =w\cdot x_{j}} where x j ∈ R d {\displaystyle x_{j}\in \mathbb {R} ^{d}} is a vector of inputs (data points) and w ∈ R d {\displaystyle w\in \mathbb {R} ^{d}} is a linear filter vector. The goal is to compute the filter vector w {\displaystyle w} . To this end, a square loss function V ( f ( x j ) , y j ) = ( f ( x j ) − y j ) 2 = ( ⟨ w , x j ⟩ − y j ) 2 {\displaystyle V(f(x_{j}),y_{j})=(f(x_{j})-y_{j})^{2}=(\langle w,x_{j}\rangle -y_{j})^{2}} is used to compute the vector w {\displaystyle w} that minimizes the empirical loss I n [ w ] = ∑ j = 1 n V ( ⟨ w , x j ⟩ , y j ) = ∑ j = 1 n ( x j T w − y j ) 2 {\displaystyle I_{n}[w]=\sum _{j=1}^{n}V(\langle w,x_{j}\rangle ,y_{j})=\sum _{j=1}^{n}(x_{j}^{\mathsf {T}}w-y_{j})^{2}} where y j ∈ R . {\displaystyle y_{j}\in \mathbb {R} .} Let X {\displaystyle X} be the i × d {\displaystyle i\times d} data matrix and y ∈ R i {\displaystyle y\in \mathbb {R} ^{i}} is the column vector of target values after the arrival of the first i {\displaystyle i} data points. Assuming that the covariance matrix Σ i = X T X {\displaystyle \Sigma _{i}=X^{\mathsf {T}}X} is invertible (otherwise it is preferential to proceed in a similar fashion with Tikhonov regularization), the best solution f ∗ ( x ) = ⟨ w ∗ , x ⟩ {\displaystyle f^{}(x)=\langle w^{},x\rangle } to the linear least squares problem is given by w ∗ = ( X T X ) − 1 X T y = Σ i − 1 ∑ j = 1 i x j y j . {\displaystyle w^{}=(X^{\mathsf {T}}X)^{-1}X^{\mathsf {T}}y=\Sigma _{i}^{-1}\sum _{j=1}^{i}x_{j}y_{j}.} Now, calculating the covariance matrix Σ i = ∑ j = 1 i x j x j T {\displaystyle \Sigma _{i}=\sum _{j=1}^{i}x_{j}x_{j}^{\mathsf {T}}} takes time O ( i d 2 ) {\displaystyle O(id^{2})} , inverting the d × d {\displaystyle d\times d} matrix takes time O ( d 3 ) {\displaystyle O(d^{3})} , while the rest of the multiplication takes time O ( d 2 ) {\displaystyle O(d^{2})} , giving a total time of O ( i d 2 + d 3 ) {\displaystyle O(id^{2}+d^{3})} . When there are n {\displaystyle n} total points in the dataset, to recompute the solution after the arrival of every datapoint i = 1 , … , n {\displaystyle i=1,\ldots ,n} , the naive approach will have a total complexity O ( n 2 d 2 + n d 3 ) {\displaystyle O(n^{2}d^{2}+nd^{3})} . Note that when storing the matrix Σ i {\displaystyle \Sigma _{i}} , then updating it at each step needs only adding x i + 1 x i + 1 T {\displaystyle x_{i+1}x_{i+1}^{\mathsf {T}}} , which takes O ( d 2 ) {\displaystyle O(d^{2})} time, reducing the total time to O ( n d 2 + n d 3 ) = O ( n d 3 ) {\displaystyle O(nd^{2}+nd^{3})=O(nd^{3})} , but with an additional storage space of O ( d 2 ) {\displaystyle O(d^{2})} to store Σ i {\displaystyle \Sigma _{i}} . === Online learning: recursive least squares === The recursive least squares (RLS) algorithm considers an online approach to the least squares problem. It can be shown that by initialising w 0 = 0 ∈ R d {\displaystyle \textstyle w_{0}=0\in \mathbb {R} ^{d}} and Γ 0 = I ∈ R d × d {\displaystyle \textstyle \Gamma _{0}=I\in \mathbb {R} ^{d\times d}} , the solution of the linear least squares problem given in the previous section can be computed by the following iteration: Γ i = Γ i − 1 − Γ i − 1 x i x i T Γ i − 1 1 + x i T Γ i − 1 x i {\displaystyle \Gamma _{i}=\Gamma _{i-1}-{\frac {\Gamma _{i-1}x_{i}x_{i}^{\mathsf {T}}\Gamma _{i-1}}{1+x_{i}^{\mathsf {T}}\Gamma _{i-1}x_{i}}}} w i = w i − 1 − Γ i x i ( x i T w i − 1 − y i ) {\displaystyle w_{i}=w_{i-1}-\Gamma _{i}x_{i}\left(x_{i}^{\mathsf {T}}w_{

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  • Switch (app)

    Switch (app)

    Switch was a mobile-only job-matching app that connected candidates directly to hiring managers. Candidates could upload their resumes and connect their social and professional media profiles, but remain anonymous while searching. Users received a daily set of job recommendations that fit their backgrounds and salary criteria, and swipe right to apply. Employers post many jobs on Switch directly, which eliminates the need for third-party job boards and recruiters, and connects job seekers to hiring managers. Switch reveals a candidate’s identity to one employer at a time, only after the candidate matches with that employer. When candidates and employers match, they can chat within the app. Switch is available for iOS, with an Android version in development. == History == === Founding === Yarden Tadmor founded Switch in New York City in January 2014. For the first 10 months, Tadmor funded the company himself. By December 2014, Switch had raised $1.4 million in funding from venture capitals firms Metamorphic Ventures, SG VC, BAM and Rhodium. Tadmor's inspiration for Switch came after being frustrated by his experience both as a job seeker, and also as a supervisor hiring at numerous technology startup companies. Tadmor has said of Switch, “We operate on the five-second resume principle, which is usually the amount of time a recruiter spends on a resume. They scan through the typical data points and move on.” Switch was designed for passive job seekers to browse openings discreetly and connect quickly. Originally, Switch served only the New York metro area technology sector while in early beta, but Tadmor always intended to expand into national coverage. Soon, the company started including all major metropolitan markets across the U.S. In May 2015, Switch announced it would start sourcing tech and media jobs from all the job boards available online. Later in 2015, Switch began to post jobs in smaller urban areas. The company also expanded industries and jobs to include restaurant staff, retail sales, healthcare, nursing and education. Tadmor subsequently founded Livekick, a one-on-one private fitness and yoga instruction company, based in New York. == Operation == In May 2015, Switch reported generating over 400,000 job applications. The company said that nine of the 50 largest websites in the U.S. were using the service. It had grown its customer base to thousands of companies in a few months from launch including Microsoft, Amazon, Facebook, IBM, Yahoo!, eBay, DropBox, SoundCloud, and Wikipedia. John Cline, software development manager at eBay, told ABC’s Good Morning America that Switch is now his “main way of finding new prospective employees.” Switch uses a double opt-in technique, meaning job seekers and employers must both say yes before moving forward. They also use swiping technology and intelligent matching algorithms to connect job seekers and employers. The user experience is different for each group, but the major attraction for both sides is the speed at which they can be connected. === Features === Swipe is a major aspect of the Switch user experience. Job seekers swipe to apply to jobs, or left to pass on positions. Employers respond and swipe right to reciprocate interest, or left to eliminate the candidate. Direct connection between job seekers and employers allows hiring managers and job seekers to start an immediate conversation. Hiring managers can message with job seekers within the app, and both parties can quickly vet one another and decide whether to move forward. Easy profile creation from social media and in-app profile editing helps job seekers focus on finding a job. === Users === Job Seekers can either load their profile manually or pull in professional credentials from social media. They can post validated photos on their Facebook account. Switch’s matching algorithm analyzes the job seeker’s location, experience, and skills to bring them jobs they may be interested in. Job seekers swipe to apply and, if the employer shows interest too, only then does Switch’s system reveal the job seeker’s identity to the corporate recruiter or hiring manager. The job seeker and hiring manager can then chat through the app. Employers behave similarly to job seekers. Hiring managers or corporate recruiters sign up online, add open positions, then view Switch-recommended candidates or wait for job seekers to swipe right. Employers can select relevant job seekers by swiping right on their profiles, then chat directly in the app. === Subscriptions === The app is currently free for users and employers. == Company overview == === Financials === Switch closed out its seed round in May 2015 with $2 million in seed round funding. Investors include Marker VC, Metamorphic, Rhodium, 500 Startups, BAM, SG VC and Marcel Legrand. In a July 2015 interview with Tadmor, he claimed that Switch had raised $2.4 million to date. == Reception == Thanks to its swipe technology and double opt-in make-up, the media often refers to Switch as the Tinder for jobs. Switch has received features in lists and app reviews as an effective tool to improve your digital job search, particularly on the mobile platform. “It’s minimal effort to connect with relevant matches,” said Good Morning America workplace contributor Tory Johnson. “Which is what everybody wants to find.”

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  • Generalized iterative scaling

    Generalized iterative scaling

    In statistics, generalized iterative scaling (GIS) and improved iterative scaling (IIS) are two early algorithms used to fit log-linear models, notably multinomial logistic regression (MaxEnt) classifiers and extensions of it such as MaxEnt Markov models and conditional random fields. These algorithms have been largely surpassed by gradient-based methods such as L-BFGS and coordinate descent algorithms.

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  • Aleph (ILP)

    Aleph (ILP)

    Aleph (A Learning Engine for Proposing Hypotheses) is an inductive logic programming system introduced by Ashwin Srinivasan in 2001. As of 2022 it is still one of the most widely used inductive logic programming systems. It is based on the earlier system Progol. == Learning task == The input to Aleph is background knowledge, specified as a logic program, a language bias in the form of mode declarations, as well as positive and negative examples specified as ground facts. As output it returns a logic program which, together with the background knowledge, entails all of the positive examples and none of the negative examples. == Basic algorithm == Starting with an empty hypothesis, Aleph proceeds as follows: It chooses a positive example to generalise; if none are left, it aborts and outputs the current hypothesis. Then it constructs the bottom clause, that is, the most specific clause that is allowed by the mode declarations and covers the example. It then searches for a generalisation of the bottom clause that scores better on the chosen metric. It then adds the new clause to the hypothesis program and removes all examples that are covered by the new clause. == Search algorithm == Aleph searches for clauses in a top-down manner, using the bottom clause constructed in the preceding step to bound the search from below. It searches the refinement graph in a breadth-first manner, with tunable parameters to bound the maximal clause size and proof depth. It scores each clause using one of 13 different evaluation metrics, as chosen in advance by the user.

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  • Multifactor dimensionality reduction

    Multifactor dimensionality reduction

    Multifactor dimensionality reduction (MDR) is a statistical approach, also used in machine learning automatic approaches, for detecting and characterizing combinations of attributes or independent variables that interact to influence a dependent or class variable. MDR was designed specifically to identify nonadditive interactions among discrete variables that influence a binary outcome and is considered a nonparametric and model-free alternative to traditional statistical methods such as logistic regression. The basis of the MDR method is a constructive induction or feature engineering algorithm that converts two or more variables or attributes to a single attribute. This process of constructing a new attribute changes the representation space of the data. The end goal is to create or discover a representation that facilitates the detection of nonlinear or nonadditive interactions among the attributes such that prediction of the class variable is improved over that of the original representation of the data. == Illustrative example == Consider the following simple example using the exclusive OR (XOR) function. XOR is a logical operator that is commonly used in data mining and machine learning as an example of a function that is not linearly separable. The table below represents a simple dataset where the relationship between the attributes (X1 and X2) and the class variable (Y) is defined by the XOR function such that Y = X1 XOR X2. Table 1 A machine learning algorithm would need to discover or approximate the XOR function in order to accurately predict Y using information about X1 and X2. An alternative strategy would be to first change the representation of the data using constructive induction to facilitate predictive modeling. The MDR algorithm would change the representation of the data (X1 and X2) in the following manner. MDR starts by selecting two attributes. In this simple example, X1 and X2 are selected. Each combination of values for X1 and X2 are examined and the number of times Y=1 and/or Y=0 is counted. In this simple example, Y=1 occurs zero times and Y=0 occurs once for the combination of X1=0 and X2=0. With MDR, the ratio of these counts is computed and compared to a fixed threshold. Here, the ratio of counts is 0/1 which is less than our fixed threshold of 1. Since 0/1 < 1 we encode a new attribute (Z) as a 0. When the ratio is greater than one we encode Z as a 1. This process is repeated for all unique combinations of values for X1 and X2. Table 2 illustrates our new transformation of the data. Table 2 The machine learning algorithm now has much less work to do to find a good predictive function. In fact, in this very simple example, the function Y = Z has a classification accuracy of 1. A nice feature of constructive induction methods such as MDR is the ability to use any data mining or machine learning method to analyze the new representation of the data. Decision trees, neural networks, or a naive Bayes classifier could be used in combination with measures of model quality such as balanced accuracy and mutual information. == Machine learning with MDR == As illustrated above, the basic constructive induction algorithm in MDR is very simple. However, its implementation for mining patterns from real data can be computationally complex. As with any machine learning algorithm there is always concern about overfitting. That is, machine learning algorithms are good at finding patterns in completely random data. It is often difficult to determine whether a reported pattern is an important signal or just chance. One approach is to estimate the generalizability of a model to independent datasets using methods such as cross-validation. Models that describe random data typically don't generalize. Another approach is to generate many random permutations of the data to see what the data mining algorithm finds when given the chance to overfit. Permutation testing makes it possible to generate an empirical p-value for the result. Replication in independent data may also provide evidence for an MDR model but can be sensitive to difference in the data sets. These approaches have all been shown to be useful for choosing and evaluating MDR models. An important step in a machine learning exercise is interpretation. Several approaches have been used with MDR including entropy analysis and pathway analysis. Tips and approaches for using MDR to model gene-gene interactions have been reviewed. == Extensions to MDR == Numerous extensions to MDR have been introduced. These include family-based methods, fuzzy methods, covariate adjustment, odds ratios, risk scores, survival methods, robust methods, methods for quantitative traits, and many others. == Applications of MDR == MDR has mostly been applied to detecting gene-gene interactions or epistasis in genetic studies of common human diseases such as atrial fibrillation, autism, bladder cancer, breast cancer, cardiovascular disease, hypertension, obesity, pancreatic cancer, prostate cancer and tuberculosis. It has also been applied to other biomedical problems such as the genetic analysis of pharmacology outcomes. A central challenge is the scaling of MDR to big data such as that from genome-wide association studies (GWAS). Several approaches have been used. One approach is to filter the features prior to MDR analysis. This can be done using biological knowledge through tools such as BioFilter. It can also be done using computational tools such as ReliefF. Another approach is to use stochastic search algorithms such as genetic programming to explore the search space of feature combinations. Yet another approach is a brute-force search using high-performance computing. == Implementations == www.epistasis.org provides an open-source and freely-available MDR software package. An R package for MDR. An sklearn-compatible Python implementation. An R package for Model-Based MDR. MDR in Weka. Generalized MDR.

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  • Security type system

    Security type system

    In computer science, a type system can be described as a syntactic framework which contains a set of rules that are used to assign a type property (int, boolean, char etc.) to various components of a computer program, such as variables or functions. A security type system works in a similar way, only with a main focus on the security of the computer program, through information flow control. Thus, the various components of the program are assigned security types, or labels. The aim of a such system is to ultimately be able to verify that a given program conforms to the type system rules and satisfies non-interference. Security type systems is one of many security techniques used in the field of language-based security, and is tightly connected to information flow and information flow policies. In simple terms, a security type system can be used to detect if there exists any kind of violation of confidentiality or integrity in a program, i.e. the programmer wants to detect if the program is in line with the information flow policy or not. == A simple information flow policy == Suppose there are two users, A and B. In a program, the following security classes (SC) are introduced: SC = {∅, {A}, {B}, {A,B}}, where ∅ is the empty set. The information flow policy should define the direction that information is allowed to flow, which is dependent on whether the policy allows read or write operations. This example considers read operations (confidentiality). The following flows are allowed: → = {({A}, {A}), ({B}, {B}), ({A,B}, {A,B}), ({A,B}, {A}), ({A,B}, {B}), ({A}, ∅), ({B}, ∅), ({A,B}, ∅)} This can also be described as a superset (⊇). In words: information is allowed to flow towards stricter levels of confidentiality. The combination operator (⊕) can express how security classes can perform read operations with respect to other security classes. For example: {A} ⊕ {A,B} = {A} — the only security class that can read from both {A} and {A,B} is {A}. {A} ⊕ {B} = ∅ — neither {A} nor {B} are allowed to read from both {A} and {B}. This can also be described as an intersection (∩) between security classes. An information flow policy can be illustrated as a Hasse diagram. The policy should also be a lattice, that is, it has a greatest lower-bound and least upper-bound (there always exists a combination between security classes). In the case of integrity, information will flow in the opposite direction, thus the policy will be inverted. == Information flow policy in security type systems == Once the policy is in place, the software developer can apply the security classes to the program components. Use of a security type system is usually combined with a compiler that can perform the verification of the information flow according to the type system rules. For the sake of simplicity, a very simple computer program, together with the information flow policy as described in the previous section, can be used as a demonstration. The simple program is given in the following pseudocode: if y{A} = 1 then x{A,B} := 0 else x{A,B} := 1 Here, an equality check is made on a variable y that is assigned the security class {A}. A variable x with a lower security class ({A,B}) is influenced by this check. This means that information is leaking from class {A} to class {A,B}, which is a violation of the confidentiality policy. This leak should be detected by the security type system. === Example === Designing a security type system requires a function (also known as a security environment) that creates a mapping from variables to security types, or classes. This function can be called Γ, such that Γ(x) = τ, where x is a variable and τ is the security class, or type. Security classes are assigned (also called "judgement") to program components, using the following notation: Types are assigned to read operations by: Γ ⊢ e : τ. Types are assigned to write operations by: Γ ⊢ S : τ cmd. Constants can be assigned any type. The following bottom-up notation can be used to decompose the program: ⁠assumption1 ... assumptionn/conclusion⁠. Once the program is decomposed into trivial judgements, by which the type can easily be determined, the types for the less trivial parts of the program can be derived. Each "numerator" is considered in isolation, looking at the type of each statement to see if an allowed type can be derived for the "denominator", based on the defined type system "rules". ==== Rules ==== The main part of the security type system is the rules. They say how the program should be decomposed and how type verification should be performed. This toy program consists of a conditional test and two possible variable assignments. Rules for these two events are defined as follows: Applying this to the simple program introduced above yields: The type system detects the policy violation in line 2, where a read operation of security class {A} is performed, followed by two write operations of a less strict security class {A,B}. In more formalized terms, {A} ⋢ {A,B}, {A,B} (from the rule of the conditional test). Thus, the program is classified as "not typeable". === Soundness === The soundness of a security type system can be informally defined as: If program P is well typed, P satisfies non-interference. Volpano, Smith and Irvine were the first to prove soundness of a security type system for a deterministic imperative programming language with a standard (non-instrumented) semantics using the notion of non-interference.

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  • Dendrogram

    Dendrogram

    A dendrogram is a diagram representing a tree graph. This diagrammatic representation is frequently used in different contexts: in hierarchical clustering, it illustrates the arrangement of the clusters produced by the corresponding analyses. in computational biology, it shows the clustering of genes or samples, sometimes in the margins of heatmaps. in phylogenetics, it displays the evolutionary relationships among various biological taxa. In this case, the dendrogram is also called a phylogenetic tree. The name dendrogram derives from the two ancient greek words δένδρον (déndron), meaning "tree", and γράμμα (grámma), meaning "drawing, mathematical figure". == Clustering example == For a clustering example, suppose that five taxa ( a {\displaystyle a} to e {\displaystyle e} ) have been clustered by UPGMA based on a matrix of genetic distances. The hierarchical clustering dendrogram would show a column of five nodes representing the initial data (here individual taxa), and the remaining nodes represent the clusters to which the data belong, with the arrows representing the distance (dissimilarity). The distance between merged clusters is monotone, increasing with the level of the merger: the height of each node in the plot is proportional to the value of the intergroup dissimilarity between its two daughters (the nodes on the right representing individual observations all plotted at zero height).

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  • Sum of absolute transformed differences

    Sum of absolute transformed differences

    The sum of absolute transformed differences (SATD) is a block matching criterion widely used in fractional motion estimation for video compression. It works by taking a frequency transform, usually a Hadamard transform, of the differences between the pixels in the original block and the corresponding pixels in the block being used for comparison. The transform itself is often of a small block rather than the entire macroblock. For example, in x264, a series of 4×4 blocks are transformed rather than doing the more processor-intensive 16×16 transform. == Comparison to other metrics == SATD is slower than the sum of absolute differences (SAD), both due to its increased complexity and the fact that SAD-specific MMX and SSE2 instructions exist, while there are no such instructions for SATD. However, SATD can still be optimized considerably with SIMD instructions on most modern CPUs. The benefit of SATD is that it more accurately models the number of bits required to transmit the residual error signal. As such, it is often used in video compressors, either as a way to drive and estimate rate explicitly, such as in the Theora encoder (since 1.1 alpha2), as an optional metric used in wide motion searches, such as in the Microsoft VC-1 encoder, or as a metric used in sub-pixel refinement, such as in x264.

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