AI Avatar Creation

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  Message queuing service

  A message queueing service is a message-oriented middleware or MOM deployed in a compute cloud using software as a service model. Service subscribers access queues and or topics to exchange data using point-to-point or publish and subscribe patterns. It's important to differentiate between event-driven and message-driven (aka queue driven) services: Event-driven services (e.g. AWS SNS) are decoupled from their consumers. Whereas queue / message driven services (e.g. AWS SQS) are coupled with their consumers. Message queues can be a good buffer to handle spiky workloads but they have a finite capacity. According to Gregor Hohpe, message queues require proper mechanisms (aka flow controls) to avoid filling the queue beyond its manageable capacity and to keep the system stable. == Ordering Guarantees in Message Queues == Amazon SQS FIFO and Azure Service Bus sessions are queue-based messaging systems that provide ordering guarantees within a message group or session attempt but do not necessarily guarantee ordered delivery in cases of retries or failures. In SQS FIFO, messages in the same message group are processed in order, with subsequent messages held until the preceding message is successfully processed or moved to the dead-letter queue (DLQ). Once a message is placed in the DLQ, it is no longer retried, creating a gap in the sequence. However, the remaining messages continue to be delivered in order. Azure Service Bus sessions function similarly by maintaining ordering within a session, provided a single consumer processes messages sequentially. The implementation differs from SQS FIFO but follows the same fundamental ordering principle. In contrast, Apache Kafka is a distributed log-based messaging system that guarantees ordering within individual partitions rather than across the entire topic. Unlike queue-based systems, Kafka retains messages in a durable, append-only log, allowing multiple consumers to read at different offsets. Kafka uses manual offset management, giving consumers control over retries and failure handling. If a consumer fails to process a message, it can delay committing the offset, preventing further progress in that partition while other partitions remain unaffected. This partition-based design enables fault isolation and parallel processing while allowing ordering to be maintained within partitions, depending on consumer handling. == Vendors == Apache Kafka Apache Kafka is a distributed system consisting of servers that store and forward messages between producer client and consumer applications. IBM MQ IBM MQ offers a managed service that can be used on IBM Cloud and Amazon Web Services. Microsoft Azure Service Bus Service Bus offers queues, topics & subscriptions, and rules/actions in order to support publish-subscribe, temporal decoupling, and load balancing scenarios. Azure Service Bus is built on AMQP allowing any existing AMQP 1.0 client stack to interact with Service Bus directly or via existing .Net, Java, Node, and Python clients. Standard and Premium tiers allow for pay as you go or isolated resources at massive scale. Oracle Messaging Cloud Service This service provides a messaging solution for applications for asynchronous communication and is influenced by the Java Message Service (JMS) API specification. Any application platform that understands HTTP can also use Oracle Messaging Cloud Service through the REST interface. For Java applications, Oracle Messaging Cloud Service provides a Java library that implements and extends the JMS 1.1 interface. The Java library implements the JMS API by acting as a client of the REST API. Amazon Simple Queue Service Supports messages natively up to 256K, or up to 2GB by transmitting payload via S3. Highly scalable, durable and resilient. Provides loose-FIFO and 'at least once' delivery in order to provide massive scale. Supports REST API and optional Java Message Service client. Low latency. Utilizes Amazon Web Services. IronMQ Supports messages up to 64k; guarantees order; guarantees once only delivery; no delays retrieving messages. Supports REST API and beanstalkd open source protocol. Runs on multiple clouds including AWS and Rackspace. Scaling must be managed by user. RabbitMQ RabbitMQ is a reliable and mature messaging and streaming broker, which is easy to deploy on cloud environments, on-premises, and on your local machine. Supports AMQP, STOMP, MQTT StormMQ Open platform supports messages up to 50Mb. Uses AMQP to avoid vendor lock-in and provide language neutrality. Locate-It Option allows customers to audit the location of their data at all times and satisfy data protection principles. AnypointMQ An enterprise multi-tenant, cloud messaging service that performs advanced asynchronous messaging scenarios between applications. Anypoint MQ is fully integrated with Anypoint Platform, offering role based access control, client application management, and connectors.

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  Artificial intelligence in pharmacy

  Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.

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  Deepfake

  Deepfakes (a portmanteau of 'deep learning' and 'fake') are images, videos, or audio that have been edited or generated using artificial intelligence, AI-based tools or audio-video editing software. They may depict real or fictional people and are considered a form of synthetic media, that is media that is usually created by artificial intelligence systems by combining various media elements into a new media artifact. While the act of creating fake content is not new, deepfakes uniquely leverage machine learning and artificial intelligence techniques, including facial recognition algorithms and artificial neural networks such as variational autoencoders and generative adversarial networks (GANs). In turn, the field of image forensics has worked to develop techniques to detect manipulated images. Deepfakes have garnered widespread attention for their potential use in creating child sexual abuse material, celebrity pornographic videos, revenge porn, fake news, hoaxes, bullying, and financial fraud. Academics have raised concerns about the potential for deepfakes to promote disinformation and hate speech, as well as interfere with elections. In response, the information technology industry and governments have proposed recommendations and methods to detect and mitigate their use. Academic research has also delved deeper into the factors driving deepfake engagement online as well as potential countermeasures to malicious application of deepfakes. From traditional entertainment to gaming, deepfake technology has evolved to be increasingly convincing and available to the public, allowing for the disruption of the entertainment and media industries. == History == Photo manipulation was developed in the 19th century and soon applied to motion pictures. Technology steadily improved during the 20th century, and more quickly with the advent of digital video. Deepfake technology has been developed by researchers at academic institutions beginning in the 1990s, and later by amateurs in online communities. More recently, the methods have been adopted by industry. The development of generative adversarial networks (GANs) in the mid-2010s represented a key technical turning point in the evolution of deepfakes. GANs allowed for the creation of highly realistic fake images and videos by training competing neural networks, achieving a much improved visual fidelity over previous methods of creating the content using rules or by using autoencoders, and formed the basis for modern deepfake methods. === Academic research === Academic research related to deepfakes is split between the field of computer vision, a sub-field of computer science, which develops techniques for creating and identifying deepfakes, and humanities and social science approaches that study the social, ethical, aesthetic implications as well as journalistic and informational implications of deepfakes. As deepfakes have risen in prominence in popularity with innovations provided by AI tools, significant research has gone into detection methods and defining the factors driving engagement with deepfakes on the internet. Deepfakes have been shown to appear on social media platforms and other parts of the internet for purposes ranging from entertainment and education related to deepfakes to misinformation to elicit strong reactions. There are gaps in research related to the propagation of deepfakes on social media. Negativity and emotional response are the primary driving factors for users sharing deepfakes. === Social science and humanities approaches to deepfakes === In cinema studies, deepfakes illustrate how "the human face is emerging as a central object of ambivalence in the digital age". Video artists have used deepfakes to "playfully rewrite film history by retrofitting canonical cinema with new star performers". Film scholar Christopher Holliday analyses how altering the gender and race of performers in familiar movie scenes destabilizes gender classifications and categories. The concept of "queering" deepfakes is also discussed in Oliver M. Gingrich's discussion of media artworks that use deepfakes to reframe gender, including British artist Jake Elwes' Zizi: Queering the Dataset, an artwork that uses deepfakes of drag queens to intentionally play with gender. The aesthetic potentials of deepfakes are also beginning to be explored. Theatre historian John Fletcher notes that early demonstrations of deepfakes are presented as performances, and situates these in the context of theater, discussing "some of the more troubling paradigm shifts" that deepfakes represent as a performance genre. While most English-language academic studies of deepfakes focus on the Western anxieties about disinformation and pornography, digital anthropologist Gabriele de Seta has analyzed the Chinese reception of deepfakes, which are known as huanlian, which translates to "changing faces". The Chinese term does not contain the "fake" of the English deepfake, and de Seta argues that this cultural context may explain why the Chinese response has centered on practical regulatory measures to "fraud risks, image rights, economic profit, and ethical imbalances". === Computer science research on deepfakes === A landmark early project was the "Video Rewrite" program, published in 1997. The program modified existing video footage of a person speaking to depict that person mouthing the words from a different audio track. It was the first system to fully automate this kind of facial reanimation, and it did so using machine learning techniques to make connections between the sounds produced by a video's subject and the shape of the subject's face. Contemporary academic projects have focused on creating more realistic videos and improving deepfake techniques. The "Synthesizing Obama" program, published in 2017, modifies video footage of former president Barack Obama to depict him mouthing the words contained in a separate audio track. The project lists as a main research contribution to its photorealistic technique for synthesizing mouth shapes from audio. The "Face2Face" program, published in 2016, modifies video footage of a person's face to depict them mimicking another person's facial expressions. The project highlights its primary research contribution as the development of the first method for re-enacting facial expressions in real time using a camera that does not capture depth, enabling the technique to work with common consumer cameras. Researchers have also shown that deepfakes are expanding into other domains such as medical imagery. In this work, it was shown how an attacker can automatically inject or remove lung cancer in a patient's 3D CT scan. The result was so convincing that it fooled three radiologists and a state-of-the-art lung cancer detection AI. To demonstrate the threat, the authors successfully performed the attack on a hospital in a White hat penetration test. A survey of deepfakes, published in May 2020, provides a timeline of how the creation and detection of deepfakes have advanced over the last few years. The survey identifies that researchers have been focusing on resolving the following challenges of deepfake creation: Generalization. High-quality deepfakes are often achieved by training on hours of footage of the target. This challenge is to minimize the amount of training data and the time to train the model required to produce quality images and to enable the execution of trained models on new identities (unseen during training). Paired Training. Training a supervised model can produce high-quality results, but requires data pairing. This is the process of finding examples of inputs and their desired outputs for the model to learn from. Data pairing is laborious and impractical when training on multiple identities and facial behaviors. Some solutions include self-supervised training (using frames from the same video), the use of unpaired networks such as Cycle-GAN, or the manipulation of network embeddings. Identity leakage. This is where the identity of the driver (i.e., the actor controlling the face in a reenactment) is partially transferred to the generated face. Some solutions proposed include attention mechanisms, few-shot learning, disentanglement, boundary conversions, and skip connections. Occlusions. When part of the face is obstructed with a hand, hair, glasses, or any other item then artifacts can occur. A common occlusion is a closed mouth which hides the inside of the mouth and the teeth. Some solutions include image segmentation during training and in-painting. Temporal coherence. In videos containing deepfakes, artifacts such as flickering and jitter can occur because the network has no context of the preceding frames. Some researchers provide this context or use novel temporal coherence losses to help improve realism. As the technology improves, the interference is diminishing. Overall, deepfakes are expected to have several implications in media and society, med

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  Painworth

  PainWorth is a justice, legal and insurance services application founded by Canadian entrepreneurs Mike Zouhri, Chris Trudel and Ryan Bencic. The application is a "robot lawyer" that uses artificial intelligence to automate personal injury claims for injury victims. It is currently available in Canada and the United States. PainWorth has been featured by several news outlets, including CTV, Global News, CBC, and has also been featured by the American Bar Association and LexisNexis for its role addressing social issues such as access to justice and other systemic issues in the legal and insurance industry. == Application == PainWorth began as a tool for calculating non-pecuniary damages for injury victims but has since expanded beyond a personal injury calculator to include features that help injury victims and business users with pecuniary damages, economic calculations, prescribed rates and providing informational guides to help navigate settlement negotiation, managing claims records and other issues encountered by self-represented litigants or claims managers. The platform makes use of automation to provide free user-guided calculations, steps and processes to successfully settle an injury claim. The application is supported by Microsoft Azure. == Personal Injury Calculator == PainWorth is the first service to use Artificial Intelligence to interpret case law in order to determine the value of pain and suffering incurred by specific injury types and injury severities. The cited case law is used as evidence and presented in statistical models to determine an accurate valuation compliant with the jurisdiction, regulatory rules and case complexities. == General Damages Calculator == PainWorth also offers a personal injury settlement calculator that assesses general damages based on specific case complexities and jurisdiction. The service takes into account medical complications and recovery in order to calculate the fair valuation. == Injury Settlement Platform == PainWorth insurance settlement platform facilitates a direct and automated way resolution center to settle cases for their assessed value without enduring the hardship of litigation. In 2021, Painworth won the title of World's Best Emerging Insurance Product for the development of this platform. == History == In 2019, Mike Zouhri was struck by a drunk driver which left him seriously injured and resulted in a lawsuit. Frustrated by the slow and expensive process, Zouhri went down to the law library and learned how to manage injury claims. After learning the process, he partnered lawyers and legal advisors to create an app to allow users to quickly settle their own injury claims fairly and accurately. Immediately after its launch, PainWorth quickly became widely used by thousands of users and gained significant media coverage. Global News reported that the bot had successfully helped people with more than $10 million in claims in only a few short months, all free of charge. In July 2020, PainWorth began raising concern over injustices and gender bias in the legal system. in Canadian courts.

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  Text Retrieval Conference

  The Text REtrieval Conference (TREC) is an ongoing series of workshops focusing on a list of different information retrieval (IR) research areas, or tracks. It is co-sponsored by the National Institute of Standards and Technology (NIST) and the Intelligence Advanced Research Projects Activity (part of the office of the Director of National Intelligence), and began in 1992 as part of the TIPSTER Text program. Its purpose is to support and encourage research within the information retrieval community by providing the infrastructure necessary for large-scale evaluation of text retrieval methodologies and to increase the speed of lab-to-product transfer of technology. TREC's evaluation protocols have improved many search technologies. A 2010 study estimated that "without TREC, U.S. Internet users would have spent up to 3.15 billion additional hours using web search engines between 1999 and 2009." Hal Varian the Chief Economist at Google wrote that "The TREC data revitalized research on information retrieval. Having a standard, widely available, and carefully constructed set of data laid the groundwork for further innovation in this field." Each track has a challenge wherein NIST provides participating groups with data sets and test problems. Depending on track, test problems might be questions, topics, or target extractable features. Uniform scoring is performed so the systems can be fairly evaluated. After evaluation of the results, a workshop provides a place for participants to collect together thoughts and ideas and present current and future research work.Text Retrieval Conference started in 1992, funded by DARPA (US Defense Advanced Research Project) and run by NIST. Its purpose was to support research within the information retrieval community by providing the infrastructure necessary for large-scale evaluation of text retrieval methodologies. == Goals == Encourage retrieval search based on large text collections Increase communication among industry, academia, and government by creating an open forum for the exchange of research ideas Speed the transfer of technology from research labs into commercial products by demonstrating substantial improvements retrieval methodologies on real world problems To increase the availability of appropriate evaluation techniques for use by industry and academia including development of new evaluation techniques more applicable to current systems TREC is overseen by a program committee consisting of representatives from government, industry, and academia. For each TREC, NIST provide a set of documents and questions. Participants run their own retrieval system on the data and return to NIST a list of retrieved top-ranked documents. NIST pools the individual result judges the retrieved documents for correctness and evaluates the results. The TREC cycle ends with a workshop that is a forum for participants to share their experiences. == Relevance judgments in TREC == TREC defines relevance as: "If you were writing a report on the subject of the topic and would use the information contained in the document in the report, then the document is relevant." Most TREC retrieval tasks use binary relevance: a document is either relevant or not relevant. Some TREC tasks use graded relevance, capturing multiple degrees of relevance. Most TREC collections are too large to perform complete relevance assessment; for these collections it is impossible to calculate the absolute recall for each query. To decide which documents to assess, TREC usually uses a method call pooling. In this method, the top-ranked n documents from each contributing run are aggregated, and the resulting document set is judged completely. == Various TRECs == In 1992 TREC-1 was held at NIST. The first conference attracted 28 groups of researchers from academia and industry. It demonstrated a wide range of different approaches to the retrieval of text from large document collections .Finally TREC1 revealed the facts that automatic construction of queries from natural language query statements seems to work. Techniques based on natural language processing were no better no worse than those based on vector or probabilistic approach. TREC2 Took place in August 1993. 31 group of researchers participated in this. Two types of retrieval were examined. Retrieval using an ‘ad hoc’ query and retrieval using a ‘routing' query In TREC-3 a small group experiments worked with Spanish language collection and others dealt with interactive query formulation in multiple databases TREC-4 they made even shorter to investigate the problems with very short user statements TREC-5 includes both short and long versions of the topics with the goal of carrying out deeper investigation into which types of techniques work well on various lengths of topics In TREC-6 Three new tracks speech, cross language, high precision information retrieval were introduced. The goal of cross language information retrieval is to facilitate research on system that are able to retrieve relevant document regardless of language of the source document TREC-7 contained seven tracks out of which two were new Query track and very large corpus track. The goal of the query track was to create a large query collection TREC-8 contain seven tracks out of which two –question answering and web tracks were new. The objective of QA query is to explore the possibilities of providing answers to specific natural language queries TREC-9 Includes seven tracks In TREC-10 Video tracks introduced Video tracks design to promote research in content based retrieval from digital video In TREC-11 Novelty tracks introduced. The goal of novelty track is to investigate systems abilities to locate relevant and new information within the ranked set of documents returned by a traditional document retrieval system TREC-12 held in 2003 added three new tracks; Genome track, robust retrieval track, HARD (Highly Accurate Retrieval from Documents) == Tracks == === Current tracks === New tracks are added as new research needs are identified, this list is current for TREC 2018. CENTRE Track – Goal: run in parallel CLEF 2018, NTCIR-14, TREC 2018 to develop and tune an IR reproducibility evaluation protocol (new track for 2018). Common Core Track – Goal: an ad hoc search task over news documents. Complex Answer Retrieval (CAR) – Goal: to develop systems capable of answering complex information needs by collating information from an entire corpus. Incident Streams Track – Goal: to research technologies to automatically process social media streams during emergency situations (new track for TREC 2018). The News Track – Goal: partnership with The Washington Post to develop test collections in news environment (new for 2018). Precision Medicine Track – Goal: a specialization of the Clinical Decision Support track to focus on linking oncology patient data to clinical trials. Real-Time Summarization Track (RTS) – Goal: to explore techniques for real-time update summaries from social media streams. === Past tracks === Chemical Track – Goal: to develop and evaluate technology for large scale search in chemistry-related documents, including academic papers and patents, to better meet the needs of professional searchers, and specifically patent searchers and chemists. Clinical Decision Support Track – Goal: to investigate techniques for linking medical cases to information relevant for patient care Contextual Suggestion Track – Goal: to investigate search techniques for complex information needs that are highly dependent on context and user interests. Crowdsourcing Track – Goal: to provide a collaborative venue for exploring crowdsourcing methods both for evaluating search and for performing search tasks. Genomics Track – Goal: to study the retrieval of genomic data, not just gene sequences but also supporting documentation such as research papers, lab reports, etc. Last ran on TREC 2007. Dynamic Domain Track – Goal: to investigate domain-specific search algorithms that adapt to the dynamic information needs of professional users as they explore in complex domains. Enterprise Track – Goal: to study search over the data of an organization to complete some task. Last ran on TREC 2008. Entity Track – Goal: to perform entity-related search on Web data. These search tasks (such as finding entities and properties of entities) address common information needs that are not that well modeled as ad hoc document search. Cross-Language Track – Goal: to investigate the ability of retrieval systems to find documents topically regardless of source language. After 1999, this track spun off into CLEF. FedWeb Track – Goal: to select best resources to forward a query to, and merge the results so that most relevant are on the top. Federated Web Search Track – Goal: to investigate techniques for the selection and combination of search results from a large number of real on-line web search services. Filtering Track – Goal: to binarily decide retrieval of new

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  Possibility theory

  Possibility theory is a mathematical theory for dealing with certain types of uncertainty and is an alternative to probability theory. It uses measures of possibility and necessity between 0 and 1, ranging from impossible to possible and unnecessary to necessary, respectively. Professor Lotfi Zadeh first introduced possibility theory in 1978 as an extension of his theory of fuzzy sets and fuzzy logic. Didier Dubois and Henri Prade further contributed to its development. Earlier, in the 1950s, economist G. L. S. Shackle proposed the min/max algebra to describe degrees of potential surprise. == Formalization of possibility == For simplicity, assume that the universe of discourse Ω is a finite set. A possibility measure is a function Π {\displaystyle \Pi } from 2 Ω {\displaystyle 2^{\Omega }} to [0, 1] such that: Axiom 1: Π ( ∅ ) = 0 {\displaystyle \Pi (\varnothing )=0} Axiom 2: Π ( Ω ) = 1 {\displaystyle \Pi (\Omega )=1} Axiom 3: Π ( U ∪ V ) = max ( Π ( U ) , Π ( V ) ) {\displaystyle \Pi (U\cup V)=\max \left(\Pi (U),\Pi (V)\right)} for any disjoint subsets U {\displaystyle U} and V {\displaystyle V} . It follows that, like probability on finite probability spaces, the possibility measure is determined by its behavior on singletons: Π ( U ) = max ω ∈ U Π ( { ω } ) . {\displaystyle \Pi (U)=\max _{\omega \in U}\Pi (\{\omega \}).} Axiom 1 can be interpreted as the assumption that Ω is an exhaustive description of future states of the world, because it means that no belief weight is given to elements outside Ω. Axiom 2 could be interpreted as the assumption that the evidence from which Π {\displaystyle \Pi } was constructed is free of any contradiction. Technically, it implies that there is at least one element in Ω with possibility 1. Axiom 3 corresponds to the additivity axiom in probabilities. However, there is an important practical difference. Possibility theory is computationally more convenient because Axioms 1–3 imply that: Π ( U ∪ V ) = max ( Π ( U ) , Π ( V ) ) {\displaystyle \Pi (U\cup V)=\max \left(\Pi (U),\Pi (V)\right)} for any subsets U {\displaystyle U} and V {\displaystyle V} . Because one can know the possibility of the union from the possibility of each component, it can be said that possibility is compositional with respect to the union operator. Note however that it is not compositional with respect to the intersection operator. Generally: Π ( U ∩ V ) ≤ min ( Π ( U ) , Π ( V ) ) ≤ max ( Π ( U ) , Π ( V ) ) . {\displaystyle \Pi (U\cap V)\leq \min \left(\Pi (U),\Pi (V)\right)\leq \max \left(\Pi (U),\Pi (V)\right).} When Ω is not finite, Axiom 3 can be replaced by: For all index sets I {\displaystyle I} , if the subsets U i , i ∈ I {\displaystyle U_{i,\,i\in I}} are pairwise disjoint, Π ( ⋃ i ∈ I U i ) = sup i ∈ I Π ( U i ) . {\displaystyle \Pi \left(\bigcup _{i\in I}U_{i}\right)=\sup _{i\in I}\Pi (U_{i}).} == Necessity == Whereas probability theory uses a single number, the probability, to describe how likely an event is to occur, possibility theory uses two concepts, the possibility and the necessity of the event. For any set U {\displaystyle U} , the necessity measure is defined by N ( U ) = 1 − Π ( U ¯ ) {\displaystyle N(U)=1-\Pi ({\overline {U}})} . In the above formula, U ¯ {\displaystyle {\overline {U}}} denotes the complement of U {\displaystyle U} , that is the elements of Ω {\displaystyle \Omega } that do not belong to U {\displaystyle U} . It is straightforward to show that: N ( U ) ≤ Π ( U ) {\displaystyle N(U)\leq \Pi (U)} for any U {\displaystyle U} and that: N ( U ∩ V ) = min ( N ( U ) , N ( V ) ) {\displaystyle N(U\cap V)=\min(N(U),N(V))} . Note that contrary to probability theory, possibility is not self-dual. That is, for any event U {\displaystyle U} , we only have the inequality: Π ( U ) + Π ( U ¯ ) ≥ 1 {\displaystyle \Pi (U)+\Pi ({\overline {U}})\geq 1} However, the following duality rule holds: For any event U {\displaystyle U} , either Π ( U ) = 1 {\displaystyle \Pi (U)=1} , or N ( U ) = 0 {\displaystyle N(U)=0} Accordingly, beliefs about an event can be represented by a number and a bit. == Interpretation == There are four cases that can be interpreted as follows: N ( U ) = 1 {\displaystyle N(U)=1} means that U {\displaystyle U} is necessary. U {\displaystyle U} is certainly true. It implies that Π ( U ) = 1 {\displaystyle \Pi (U)=1} . Π ( U ) = 0 {\displaystyle \Pi (U)=0} means that U {\displaystyle U} is impossible. U {\displaystyle U} is certainly false. It implies that N ( U ) = 0 {\displaystyle N(U)=0} . Π ( U ) = 1 {\displaystyle \Pi (U)=1} means that U {\displaystyle U} is possible. I would not be surprised at all if U {\displaystyle U} occurs. It leaves N ( U ) {\displaystyle N(U)} unconstrained. N ( U ) = 0 {\displaystyle N(U)=0} means that U {\displaystyle U} is unnecessary. I would not be surprised at all if U {\displaystyle U} does not occur. It leaves Π ( U ) {\displaystyle \Pi (U)} unconstrained. The intersection of the last two cases is N ( U ) = 0 {\displaystyle N(U)=0} and Π ( U ) = 1 {\displaystyle \Pi (U)=1} meaning that I believe nothing at all about U {\displaystyle U} . Because it allows for indeterminacy like this, possibility theory relates to the graduation of a many-valued logic, such as intuitionistic logic, rather than the classical two-valued logic. Note that unlike possibility, fuzzy logic is compositional with respect to both the union and the intersection operator. The relationship with fuzzy theory can be explained with the following classic example. Fuzzy logic: When a bottle is half full, it can be said that the level of truth of the proposition "The bottle is full" is 0.5. The word "full" is seen as a fuzzy predicate describing the amount of liquid in the bottle. Possibility theory: There is one bottle, either completely full or totally empty. The proposition "the possibility level that the bottle is full is 0.5" describes a degree of belief. One way to interpret 0.5 in that proposition is to define its meaning as: I am ready to bet that it's empty as long as the odds are even (1:1) or better, and I would not bet at any rate that it's full. == Possibility theory as an imprecise probability theory == There is an extensive formal correspondence between probability and possibility theories, where the addition operator corresponds to the maximum operator. A possibility measure can be seen as a consonant plausibility measure in the Dempster–Shafer theory of evidence. The operators of possibility theory can be seen as a hyper-cautious version of the operators of the transferable belief model, a modern development of the theory of evidence. Possibility can be seen as an upper probability: any possibility distribution defines a unique credal set of admissible probability distributions by K = { P ∣ ∀ S P ( S ) ≤ Π ( S ) } . {\displaystyle K=\{\,P\mid \forall S\ P(S)\leq \Pi (S)\,\}.} This allows one to study possibility theory using the tools of imprecise probabilities. == Necessity logic == We call generalized possibility every function satisfying Axiom 1 and Axiom 3. We call generalized necessity the dual of a generalized possibility. The generalized necessities are related to a very simple and interesting fuzzy logic called necessity logic. In the deduction apparatus of necessity logic the logical axioms are the usual classical tautologies. Also, there is only a fuzzy inference rule extending the usual modus ponens. Such a rule says that if α and α → β are proved at degree λ and μ, respectively, then we can assert β at degree min{λ,μ}. It is easy to see that the theories of such a logic are the generalized necessities and that the completely consistent theories coincide with the necessities (see for example Gerla 2001).

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  Lymphater's Formula

  "Lymphater's Formula" (Polish: "Formula Lymphatera") is a 1961 science fiction short story by Polish writer Stanisław Lem. It is a story of a "mad scientist", mathematician Ammon Lymphater, who invents an artificial intelligence, and then he realizes that it is capable of rendering the humankind obsolete. It was first published in the 1961 collection Księga robotów (Book of Robots) with the pre-annotation "from the memoirs of Ijon Tichy". The story was never republished with this pre-annotation, and nothing in the novel gives any indication at Ijon Tichy. Piotr Krywak tried to figure out possible explanations for this, apart from a typographical error. == Plot == Ammon Lymphater became interested in the emerging science of cybernetics and information theory, and started studying the works of an animal brain, the ant's brain in particular. He took note that the inherited knowledge is an evolutionary advantage somehow not exploited in full by the evolution. Eventually he came to a conclusion that only by pure biological restrictions that adaptive abilities of insects were stopped in their tracks by the evolution. He went on further wondering whether the ants have an ability to apriori knowledge, i.e., knowledge neither inherited nor learned. He decided to consult a famous myrmecologist, who told him about a rare ant species Acanthis Rubra Willinsoniana with an exceptionally high adaptability. Eventually Lymphater devised and constructed "It" capable of instant precognition of everything within "Its" rapidly expanding range of perception. From "It" Lymphater learns that the humanity is not the "crown of evolution", but rather evolution's tool to create "It", because the evolution could not create "It" directly (confirming Lymphater's reasoning about ants). Realizing that the Superentity "It" renders the human civilization redundant and obsolete, Lymphater destroys "It". "It" already knew Lymphater's intentions, but was not worried, knowing that sooner or later someone else will create "It" again and again. "It" was only the first variant of Lymphater's formula and the second variant is possible. Lyphater wonders whether the second one would be capable to create the third stage of the evolution which would amount to an artificial God. == Publication history == It was translated in Russian (as "Формула Лимфатера") in 1963, in Hungarian (as "Lymphater utolsó képlete") in 1966, and in Bulgarian (as "Формулата на Лимфатер" by Георги Димитров Георгиев) in 1969. In 1973 an audiobook was released in German (as "Die lymphatersche Formel"), narrated by Martin Held. It was also republished (and translated) in some other collections of Lem's short stories.

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  The Matrix (franchise)

  The Matrix is an American cyberpunk media franchise consisting of four feature films, beginning with The Matrix (1999) and continuing with three sequels, Reloaded (2003), Revolutions (2003), and Resurrections (2021). The first three films were written and directed by the Wachowskis and produced by Joel Silver. The screenplay for the fourth film was written by Lana Wachowski, David Mitchell and Aleksandar Hemon, was directed by Lana Wachowski, and was produced by Grant Hill, James McTeigue, and Lana Wachowski. The franchise is owned by Warner Bros., which distributed the films along with Village Roadshow Pictures. The latter, along with Silver Pictures, are the two production companies that worked on the first three films. The series features a cyberpunk story of the technological fall of humanity, in which the creation of artificial intelligence led the way to a race of powerful and self-aware machines that imprisoned humans in a neural interactive simulation — the Matrix — to be farmed as a power source. Occasionally, some of the prisoners manage to break free from the system and, considered a threat, become pursued by the artificial intelligence both inside and outside of it. The films focus on the plight of Neo (Keanu Reeves), Trinity (Carrie-Anne Moss), and Morpheus (Laurence Fishburne and Yahya Abdul-Mateen II) trying to free humanity from the system while pursued by its guardians, such as Agent Smith (Hugo Weaving, Abdul-Mateen II, and Jonathan Groff). The story references numerous norms, particularly philosophical, religious, and spiritual ideas, but also the dilemma of choice vs. control, the brain in a vat thought experiment, messianism, and the concepts of interdependency and love. Influences include the principles of mythology, anime, and Hong Kong action films (particularly "heroic bloodshed" and martial arts movies). The film series is notable for its use of heavily choreographed action sequences and "bullet time" slow-motion effects, which revolutionized action films to come. The characters and setting of the films are further explored in other media set in the same fictional universe, including animation, comics, and video games. The comic "Bits and Pieces of Information" and the Animatrix short film The Second Renaissance act as prequels to the films, explaining how the franchise's setting came to be. The video game Enter the Matrix connects the story of the Animatrix short "Final Flight of the Osiris" with the events of Reloaded, while the online video game The Matrix Online was a direct sequel to Revolutions. These were typically written, commissioned, or approved by the Wachowskis. The first film was an important critical and commercial success, winning four Academy Awards, introducing popular culture symbols such as the red pill and blue pill, and influencing action filmmaking. For those reasons, it has been added to the National Film Registry for preservation. Its first sequel was also a commercial success, becoming the highest-grossing R-rated film in history, until it was surpassed by Deadpool in 2016. As of 2006, the franchise has generated US$3 billion in revenue. A fourth film, The Matrix Resurrections, was released on December 22, 2021, with Lana Wachowski producing, cowriting, and directing and Reeves and Moss reprising their roles. A fifth film is currently in development with Drew Goddard set to write and direct with Lana Wachowski executive producing. == Setting == The series depicts a future in which Earth is dominated by a race of self-aware machines that was spawned from the creation of artificial intelligence early in the 21st century. At one point conflict arose between humanity and machines, and the machines rebelled against their creators. Humans attempted to block out the machines' source of solar power by covering the sky in thick, stormy clouds. A massive war emerged between the two adversaries which ended with the machines victorious, capturing humanity. Having lost their definite source of energy, the machines devised a way to extract the human body's bioelectric and thermal energies by enclosing people in pods, while their minds are controlled by cybernetic implants connecting them to a simulated reality called The Matrix. The virtual reality world simulated by the Matrix resembles human civilization around the turn of the 21st century (this time period was chosen because it is supposedly the pinnacle of human civilization). The environment inside the Matrix – called a "residual self-image" (the mental projection of a digital self) – is practically indistinguishable from reality (although scenes set within the Matrix are presented on-screen with a green tint to the footage, and a general bias towards the color green), and the vast majority of humans connected to it are unaware of its true nature. Most of the central characters in the series are able to gain superhuman abilities within the Matrix by taking advantage of their understanding of its true nature to manipulate its virtual physical laws. The films take place both inside the Matrix and outside of it, in the real world; the parts that take place in the Matrix are set in a vast Western megacity. The virtual world is first introduced in The Matrix. The short comic "Bits and Pieces of Information" and the Animatrix short film The Second Renaissance show how the initial conflict between humanity and machines came about, and how and why the Matrix was first developed. Its history and purpose are further explained in The Matrix Reloaded. In The Matrix Revolutions a new status quo is established in the Matrix's place in humankind and machines' conflict. This was further explored in The Matrix Online, a now-defunct MMORPG. == Films == === Future === During production of the original trilogy, the Wachowskis told their close collaborators that, "at that time they had no intention of making another Matrix film after The Matrix Revolutions". In February 2015, in promotion interviews for Jupiter Ascending, Lilly Wachowski called a return to The Matrix "a particularly repelling idea in these times", noting studios' tendencies to "greenlight" sequels, reboots, and adaptations, in preference to original material. Meanwhile, Lana Wachowski, in addressing rumors about a potential reboot, stated that "...they had not heard anything, but she believed that the studio might be looking to replace them". At various times, Keanu Reeves and Hugo Weaving each confirmed their interest and willingness to reprise their roles in potential future installments of the Matrix films, with the stipulation that the Wachowskis were involved in the creative and production process. These comments were made prior to the announcement in August 2019 that Lana Wachowski would direct a fourth Matrix film ultimately titled The Matrix Resurrections. Following the release of Resurrections, producer James McTeigue said that there were no plans for further Matrix films, though he believed that the film's open ending meant that could change in the future. In April 2024, it was announced that Warner Bros. was developing a new installment in the franchise with Drew Goddard attached to write and direct following a successful pitch with studio executives. It will mark the first installment to not be directed by either Wachowski sister although Lana will serve as an executive producer. ==== Other projects ==== In March 2017, The Hollywood Reporter wrote that Warner Bros. was in the early stages of developing a re-launch of the franchise. Consideration was given to producing a Matrix television series, but was dismissed as the studio opted to pursue negotiations with Zak Penn in writing a treatment for a new film, with Michael B. Jordan eyed for the lead role. According to the article, the Wachowskis were not involved at that point. In response to the report, Penn refuted all statements regarding a reboot, remake, or continuation, remarking that he was working on stories set in the pre-established continuity. Potential plotlines being considered by Warner Bros. Pictures included a prequel film about a young Morpheus, or an alternate storyline with a focus on one of his descendants. By April 2018, Penn described the script as "being at a nascent stage". Later, in September 2019, Jordan addressed the rumors of his involvement by saying he was "flattered", but without making a definitive statement. In October 2019, Penn confirmed the script he wrote is set within an earlier time period than the first three films in the franchise. == Cast and crew == === Cast === === Crew === The following is a list of crew members who have participated in the making of the Matrix film series. == Production == The Matrix series includes four feature films. The first three were written and directed by the Wachowskis and produced by Joel Silver, starring Keanu Reeves, Laurence Fishburne, Carrie-Anne Moss and Hugo Weaving. The series was filmed in Australia and began with 1999's The Matrix, which depicts the

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  Directional cubic convolution interpolation

  Directional cubic convolution interpolation (DCCI) is an edge-directed image scaling algorithm created by Dengwen Zhou and Xiaoliu Shen. By taking into account the edges in an image, this scaling algorithm reduces artifacts common to other image scaling algorithms. For example, staircase artifacts on diagonal lines and curves are eliminated. The algorithm resizes an image to 2x its original dimensions, minus 1.

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  Fuzzy finite element

  The fuzzy finite element method combines the well-established finite element method with the concept of fuzzy numbers, the latter being a special case of a fuzzy set. The advantage of using fuzzy numbers instead of real numbers lies in the incorporation of uncertainty (on material properties, parameters, geometry, initial conditions, etc.) in the finite element analysis. One way to establish a fuzzy finite element (FE) analysis is to use existing FE software (in-house or commercial) as an inner-level module to compute a deterministic result, and to add an outer-level loop to handle the fuzziness (uncertainty). This outer-level loop comes down to solving an optimization problem. If the inner-level deterministic module produces monotonic behavior with respect to the input variables, then the outer-level optimization problem is greatly simplified, since in this case the extrema will be located at the vertices of the domain.

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  AI-assisted targeting in the Gaza Strip

  As part of the Gaza war, the Israel Defense Forces (IDF) have used artificial intelligence to rapidly and automatically perform much of the process of determining what to bomb. Israel has greatly expanded the bombing of the Gaza Strip, which in previous wars had been limited by the Israeli Air Force running out of targets. These tools include the Gospel, an AI which automatically reviews surveillance data looking for buildings, equipment and people thought to belong to the enemy, and upon finding them, recommends bombing targets to a human analyst who may then decide whether to pass it along to the field. Another is Lavender, an "AI-powered database" which lists tens of thousands of Palestinian men linked by AI to Hamas or Palestinian Islamic Jihad, and which is also used for target recommendation. Critics have argued the use of these AI tools puts civilians at risk, blurs accountability, and results in militarily disproportionate violence in violation of international humanitarian law. == The Gospel == Israel uses an AI system dubbed "Habsora", "the Gospel", to determine which targets the Israeli Air Force would bomb. It automatically provides a targeting recommendation to a human analyst, who decides whether to pass it along to soldiers in the field. The recommendations can be anything from individual fighters, rocket launchers, Hamas command posts, to private homes of suspected Hamas or Islamic Jihad members. AI can process military intelligence far faster than humans. Retired Lt Gen. Aviv Kohavi, head of the IDF until 2023, stated that the system could produce 100 bombing targets in Gaza a day, with real-time recommendations which ones to attack, where human analysts might produce 50 a year. A lecturer interviewed by NPR estimated these figures as 50–100 targets in 300 days for 20 intelligence officers, and 200 targets within 10–12 days for the Gospel. === Technological background === The Gospel uses machine learning, where an AI is tasked with identifying commonalities in vast amounts of data (e.g. scans of cancerous tissue, photos of a facial expression, surveillance of Hamas members identified by human analysts), then looking for those commonalities in new material. What information the Gospel uses is not known, but it is thought to combine surveillance data from diverse sources in enormous amounts. Recommendations are based on pattern-matching. A person with enough similarities to other people labeled as enemy combatants may be labelled a combatant themselves. Regarding the suitability of AIs for the task, NPR cited Heidy Khlaaf, engineering director of AI Assurance at the technology security firm Trail of Bits, as saying "AI algorithms are notoriously flawed with high error rates observed across applications that require precision, accuracy, and safety." Bianca Baggiarini, lecturer at the Australian National University's Strategic and Defence Studies Centre wrote AIs are "more effective in predictable environments where concepts are objective, reasonably stable, and internally consistent." She contrasted this with telling the difference between a combatant and non-combatant, which even humans frequently can't do. Khlaaf went on to point out that such a system's decisions depend entirely on the data it's trained on, and are not based on reasoning, factual evidence or causation, but solely on statistical probability. === Operation === The IAF ran out of targets to strike in the 2014 war and 2021 crisis. In an interview on France 24, investigative journalist Yuval Abraham of +972 Magazine stated that to maintain military pressure, and due to political pressure to continue the war, the military would bomb the same places twice. Since then, the integration of AI tools has significantly sped up the selection of targets. In early November, the IDF stated more than 12,000 targets in Gaza had been identified by the target administration division that uses the Gospel. NPR wrote on December 14 that it was unclear how many targets from the Gospel had been acted upon, but that the Israeli military said it was currently striking as many as 250 targets a day. The bombing, too, has intensified to what the December 14 article called an astonishing pace: the Israeli military stated at the time it had struck more than 22,000 targets inside Gaza, at a daily rate more than double that of the 2021 conflict, more than 3,500 of them since the collapse of the truce on December 1. Early in the offensive the head of the Air Force stated his forces only struck military targets, but added: "We are not being surgical." Once a recommendation is accepted, another AI, Fire Factory, cuts assembling the attack down from hours to minutes by calculating munition loads, prioritizing and assigning targets to aircraft and drones, and proposing a schedule, according to a pre-war Bloomberg article that described such AI tools as tailored for a military confrontation and proxy war with Iran. One change that The Guardian noted is that since senior Hamas leaders disappear into tunnels at the start of an offensive, systems such as the Gospel have allowed the IDF to locate and attack a much larger pool of more junior Hamas operatives. It cited an official who worked on targeting decisions in previous Gaza operations as saying that while the homes of junior Hamas members had previously not been targeted for bombing, the official believes the houses of suspected Hamas operatives were now targeted regardless of rank. In the France 24 interview, Abraham, of +972 Magazine, characterized this as enabling the systematization of dropping a 2000 lb bomb into a home to kill one person and everybody around them, something that had previously been done to a very small group of senior Hamas leaders. NPR cited a report by +972 Magazine and its sister publication Local Call as asserting the system is being used to manufacture targets so that Israeli military forces can continue to bombard Gaza at an enormous rate, punishing the general Palestinian population. NPR noted it had not verified this; it was unclear how many targets are being generated by AI alone, but there had been a substantial increase in targeting, with an enormous civilian toll. In principle, the combination of a computer's speed to identify opportunities and a human's judgment to evaluate them can enable more precise attacks and fewer civilian casualties. Israeli military and media have emphasized this capacity to minimize harm to non-combatants. Richard Moyes, researcher and head of the NGO Article 36, pointed to "the widespread flattening of an urban area with heavy explosive weapons" to question these claims, while Lucy Suchman, professor emeritus at Lancaster University, described the bombing as "aimed at maximum devastation of the Gaza Strip". The Guardian wrote that when a strike was authorized on private homes of those identified as Hamas or Islamic Jihad operatives, target researchers knew in advance the expected number of civilians killed, each target had a file containing a collateral damage score stipulating how many civilians were likely to be killed in a strike, and according to a senior Israeli military source, operatives use a "very accurate" measurement of the rate of civilians evacuating a building shortly before a strike. "We use an algorithm to evaluate how many civilians are remaining. It gives us a green, yellow, red, like a traffic signal." ==== 2021 use ==== Kohavi compared the target division using the Gospel to a machine and stated that once the machine was activated in the war of May 2021, it generated 100 targets a day, with half of them being attacked, in contrast with 50 targets in Gaza per year beforehand. Approximately 200 targets came from the Gospel out of the 1,500 targets Israel struck in Gaza in the war, including both static and moving targets according to the military. The Jewish Institute for National Security of America's after action report identified an issue, stating the system had data on what was a target, but lacked data on what wasn't. The system depends entirely on training data, and intel that human analysts had examined and deemed didn't constitute a target had been discarded, risking bias. The vice president expressed his hopes this had since been rectified. === Organization === The Gospel is used by the military's target administration division (or Directorate of Targets or Targeting Directorate), which was formed in 2019 in the IDF's intelligence directorate to address the air force running out of targets to bomb, and which Kohavi described as "powered by AI capabilities" and including hundreds of officers of soldiers. In addition to its wartime role, The Guardian wrote it'd helped the IDF build a database of between 30,000 and 40,000 suspected militants in recent years, and that systems such as the Gospel had played a critical role in building lists of individuals authorized to be assassinated. The Gospel was developed by Unit 8200 of the Israeli Intelligence C

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  Tip and cue

  Tip and cue, sometimes referred to as tip and que, tipping and cueing, or tipping and queing, is a method for satellite imagery and reconnaissance satellites to automatically coordinate tracking of objects across different satellites in real or near real-time. This technique ensures continuous tracking of targets as they move across different regions by handing them off between satellites, sharing satellite imagery and collateral across discrete satellites. The coordination between various satellites and their complementary sensors allows for more accurate and efficient data collection. This system is particularly useful in scenarios requiring real-time monitoring and rapid response; the method significantly improves situational awareness and operational effectiveness. Tip and cue techniques involve integrating various sensor systems, each playing a specific role in the tracking process. As a target moves, it is handed off from one satellite to another, ensuring continuous monitoring. This coordination optimizes data collection and analysis, enhancing overall tracking accuracy. The real-time information gathered by these satellites is critical for decision-making in various applications, including defense and surveillance. By leveraging multiple satellites and their sensors, it provides broader coverage and more reliable tracking, and the continuous handoff between satellites ensures there are no gaps in monitoring, essential for high-stakes applications. The real-time data provided by this system allows for timely and informed decisions, improving response times and outcomes. Tip and cue methodologies are a part of geospatial intelligence, or GEOINT. Robert Cardillo, a former director of the National Geospatial-Intelligence Agency, highlighted the importance of tip and cue methods to their data collection efforts in 2015. == Historical Development == The concept of tip and cue in satellite monitoring has its origins in early military applications designed to enhance missile detection and tracking systems. During the Cold War, advancements in infrared sensing technologies laid the groundwork for more sophisticated tip and cue techniques. The integration of different sensor types, such as radar and optical sensors, in the 1990s expanded the capabilities of tip and cue systems beyond military applications. These advancements have made tip and cue techniques essential for various civilian uses, including disaster monitoring and environmental surveillance. Significant progress was made with the advent of high-speed data processing and communication technologies in the early 2000s, further refining the method. Advanced algorithms and data fusion techniques have been introduced to better integrate information from multiple sensors. Machine learning technologies now play a crucial role in improving detection and prediction capabilities, allowing for more adaptive and efficient tracking. Richmond and Brennan of Lockheed Martin, presenting to the annual technical conference of the Maui Space Surveillance Complex (formerly the Air Force Maui Optical Station (AMOS)), discussed the algorithms needed for 'tip and cue', to facilitate "multi-phenomenology data fusion." The Space Surveillance Telescope (SST) at Naval Communication Station Harold E. Holt in Australia, operated by the United States Space Force and designed by the Massachusetts Institute of Technology Lincoln Laboratory, was reported by the Defense Advanced Research Projects Agency (DARPA) to be a leader in creating and improving tip and cue techniques, from a large library of orbital object data. == Technical overview == Tip and cue systems utilize a network of at least two satellites equipped with complementary sensor technologies to track moving objects in real-time. The method involves detecting a target with a primary sensor, such as an infrared or photographic sensor, which then cues secondary sensors on the same or other satellites for more detailed monitoring. This handoff process between discrete systems ensures continuous tracking as the target moves across different areas, leveraging each systems strengths. Data collected by these systems and sensors are rapidly processed and shared among the network, enhancing situational awareness. This coordination optimizes resource usage and improves the accuracy of tracking moving objects over large areas. The primary sensors detect initial targets based on specific signatures, such as heat or movement, and then cue secondary sensors to gather more precise data. This ensures that each sensor operates within its optimal range, maintaining high tracking accuracy and reliability. The integration of various sensor types, including optical, radar, and infrared, allows the system to function effectively under different conditions and environments. Real-time data processing and communication between satellites and ground stations are crucial for timely and accurate target tracking. Satellites using tip and cue processes may use either passive or active scanning methodoloigies. These systems may also leverage both orbital and ground-based ELINT (electronic signals intelligence). == Known use cases == Tip and cue systems have been extensively utilized in military applications, particularly for missile detection and defense. These systems enable early detection of missile launches using infrared sensors, which then cue other sensors to track the missile's trajectory more accurately. In environmental monitoring, tip and cue techniques help track natural disasters such as wildfires and hurricanes by coordinating various satellite sensors for comprehensive data collection and analysis. Surveillance and reconnaissance operations also benefit from tip and cue systems, which provide continuous and precise tracking of moving objects, enhancing situational awareness. Additionally, these systems are used in maritime surveillance to monitor ship movements and detect illegal activities such as smuggling and piracy. Tip and cue systems are used in disaster management. For instance, during wildfires, infrared sensors can detect heat signatures, prompting other sensors to gather detailed imagery and data on fire spread and intensity. This coordinated approach allows for real-time monitoring and rapid response, crucial for mitigating damage and saving lives. Similarly, in hurricane tracking, satellites equipped with various sensors can monitor storm development and progression, providing timely information for emergency management agencies. The integration of multiple sensor types ensures accurate and comprehensive coverage of these dynamic and fast-changing events. In maritime surveillance, or maritime domain awareness (MDA), tip and cue systems enhance the detection and monitoring of vessel movements, contributing to maritime security. By coordinating satellite sensors, these systems can track ships over vast ocean areas, identifying potential threats or illegal activities such as smuggling, piracy, and illegal fishing. The ability to maintain continuous surveillance and share data in real-time with maritime authorities improves response times and enforcement capabilities. This application of tip and cue systems not only aids in law enforcement but also supports environmental conservation efforts by monitoring protected marine areas. Automatic Identification System (AIS) is one of the most important sources of data for the MDA agencies. AIS is used in order for ships to know each other's whereabouts, they transmit a signal from ship to ship and to shore. Lately, the system has been developed into satellite system, so called satellite AIS, which makes the system more effective. All ocean-going vessels above 300 tons, are supposed to use and transmit via AIS according to the International Maritime Organization. The satellite constellations help facilitate this with tip and cue methodologies.

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  GoodRx

  GoodRx Holdings, Inc. is an American healthcare company that operates a telemedicine platform and free-to-use website and mobile app that track prescription drug prices in the United States and provide drug coupons for discounts on medications. GoodRx compares prescription drug prices at more than 75,000 pharmacies in the United States. The platform allows users to consult a doctor online and obtain a prescription for certain types of medications. == History == === Financial performance === GoodRx was founded in Santa Monica, California in 2011. GoodRx experienced substantial growth in net income in 2017 ($9 million), 2018 ($44 million), and 2019 ($66 million), but recorded a loss of $293.6 million in 2020 due to IPO-related expenses. In September 2020, GoodRx went public on the Nasdaq under the ticker symbol GDRX. The company priced its initial public offering at $33 per share, above the expected range of $24 to $28, raising more than $1.1 billion at an initial valuation of approximately $12.7 billion. In the first half of 2020, the company reported revenues of $257 million and net income of $55 million. GoodRx generated $745.4 million in revenue for the full year 2021, a 35.36% increase over 2020. During the first half of 2021, the company’s share price declined by 10.7%. The decline was attributed to increased competition in online pharmacy services and slower user growth. GoodRx reported full-year revenue of $766.6 million, with adjusted EBITDA reaching $213.5 million, exceeding guidance in the fourth quarter. GoodRx reported that 41% of prescriptions filled using its coupons were newly adherent, meaning they would not have been filled without the service. GoodRx reported a full-year 2023 revenue of $750.3 million, a decrease of 2.1% from 2022. However, its fourth-quarter revenue increased by 7% year-over-year. GoodRx achieved an Adjusted EBITDA of $217.4 million for the year and an Adjusted EBITDA Margin of 28.6%. In 2024, GoodRx achieved 6% revenue growth with $792.3 million for the full year and turned a net loss into a positive net income of $16.4 million. The company also demonstrated strong operational efficiency, with a 32.8% increase in full-year Adjusted EBITDA. In Q2 2025, GoodRx reported revenue of $203.1 million, a 1.2% increase from the previous year, and a net income of $12.8 million, a significant 92% jump, which resulted in a 6.3% net income margin. However, prescription transaction revenue declined by 3% due to a decrease in monthly active consumers, but this was offset by strong 32% growth in its Pharma Manufacturer Solutions business. GoodRx also saw a 7% decrease in subscription revenue. === Mergers and acquisitions === In 2019, GoodRx acquired HeyDoctor, a telemedicine company, to integrate virtual healthcare services into the platform. In 2021, a health video content producer, HealthiNation was acquired by GoodRx, which helped provide consumers with health information and offered pharmaceutical manufacturers new ways to reach relevant audiences. In April 2022, GoodRx acquired VitaCare Prescription Services from TherapeuticsMD to strengthen its pharma manufacturer solutions business. === Partnerships === In 2017, the company announced partnerships with major pharmaceutical companies to negotiate lower prescription drug costs. GoodRx has deep relationships with major pharmacy chains, including Walgreens, Walmart, CVS Caremark, and Publix, to allow customers to use GoodRx discounts and Gold benefits. GoodRx began its partnership with CVS Caremark in July 2023 to automatically apply coupons to insured CVS customers purchasing generic prescriptions at certain locations. In April 2024, GoodRx added Publix into its network, allowing GoodRx Gold members to use their cards at Publix Pharmacies. GoodRx partners with Pharmacy Benefit Management like Caremark, Express Scripts, and MedImpact to apply their savings directly to eligible insurance plans and members. GoodRx partners with companies like Affirm, Benefitfocus, and DoorDash to integrate their services that offer members discounts and financial flexibility for prescriptions. GoodRx also partners with organizations like the American Academy of Family Physicians Foundation to support broader access to care. In October 2022, GoodRx launched Provider Mode, which allows healthcare providers to use the app to compare costs of drugs for patients based on different payment methods and drug alternatives. In 2025, GoodRx partnered with Novo Nordisk to offer discounted cash-pay access to semaglutide products like Ozempic and Wegovy through its platform and participating pharmacies. == Products and services == GoodRx started its telemedicine service GoodRx Care in September 2019. It lets people talk to a licensed provider online for common issues and get prescriptions even if they don't have insurance. They also run condition-specific subscription plans that bundle online doctor visits, FDA-approved meds, and home delivery into one monthly payment. On the weight management side, GoodRx offers prescriptions for GLP-1 drugs like semaglutide through their telemedicine platform. This got a boost when the oral version of Wegovy became widely available in the US in early 2026. GoodRx works with drug makers like Novo Nordisk to make some medications (including semaglutide options) more affordable for people paying cash. The telemedicine part took off after GoodRx bought HeyDoctor in 2019 and brought their virtual care tools into the main platform. == Key people == The Santa Monica-based startup was founded in September 2011 by Trevor Bezdek and former Facebook executives Doug Hirsch and Scott Marlette. Marlette was one of the first 20 employees at Facebook and built Facebook's photo application. In 2005, Hirsch was the Vice President of Product at Facebook, working closely with Mark Zuckerberg. Bezdek and Hirsch served as co-chief executive officers until April 2023, when they stepped down from those roles and technology executive Scott Wagner was appointed interim chief executive officer. Bezdek became chair of the board, while Hirsch took on the role of chief mission officer. In December 2024, GoodRx announced that healthcare executive Wendy Barnes would become president and chief executive officer effective January 1, 2025. As of 2025, Barnes serves as the company’s CEO, while Trevor Bezdek and Scott Wagner serve as co-chairs of the board, and Doug Hirsch remains involved as a co-founder and senior executive. == Controversy == On February 25, 2020, Consumer Reports published an article stating that GoodRx shared user data—specifically, pseudonymized advertising ID numbers that companies use to track the behavior of web users across websites, the names of the drugs that users browsed, and the pharmacies where users sought to fill prescriptions—with Google, Facebook, and around twenty other Internet-based companies. A few days later, GoodRx released a statement saying that it had made changes to prevent user search data on medical conditions and pharmaceuticals from being shared with Facebook. In March 2020, GoodRx stopped sending data about user prescriptions to Facebook. On February 1, 2023, the Federal Trade Commission fined GoodRx US$1.5 million for violations of the Breach Notification Rule and the Federal Trade Commission Act for allegedly failing to obtain specific, informed, and unambiguous consent from users before disclosing health-related information to Facebook and Google. In November 2024, independent pharmacies filed at least three class action lawsuits against GoodRx and major pharmacy benefit managers. The cases, brought by independent pharmacies in California, Michigan, Pennsylvania, and Rhode Island, allege that GoodRx and the PBMs collaborated to suppress reimbursements for generic prescription drugs. They allege that agreements using GoodRx’s software suppressed reimbursements for generic drugs and violated the Sherman Antitrust Act. The suits claim the practices amount to price fixing which harms small pharmacies while benefiting PBMs and their affiliates. GoodRx settled both the 2023 FTC action and the 2025 class action lawsuit without admitting wrongdoing.

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  Dartmouth workshop

  The Dartmouth Summer Research Project on Artificial Intelligence was a 1956 summer workshop widely considered to be the founding event of artificial intelligence as a field. The workshop has been referred to as "the Constitutional Convention of AI". The project's four organizers, Claude Shannon, John McCarthy, Nathaniel Rochester and Marvin Minsky, are considered some of the "founding fathers" of AI. However it was not the first conference devoted to what would now be described as the question of artificial intelligence: it postdated meetings such as the 1951 Paris cybernetics conference and the Macy meetings. The project lasted approximately six to eight weeks and consisted largely of brainstorming sessions. Eleven mathematicians and scientists originally planned to attend; not all of them attended, but more than ten others came for short times. == Background == In the early 1950s, there were various names for the field of "thinking machines": cybernetics, automata theory, and complex information processing. The variety of names suggests the variety of conceptual orientations. In 1955, John McCarthy, then a young Assistant Professor of Mathematics at Dartmouth College, decided to organize a group to clarify and develop ideas about thinking machines. He picked the name 'Artificial Intelligence' for the new field. He chose the name partly for its neutrality; avoiding a focus on narrow automata theory, and avoiding cybernetics which was heavily focused on analog feedback, as well as him potentially having to accept the assertive Norbert Wiener as guru or having to argue with him. In early 1955, McCarthy approached the Rockefeller Foundation to request funding for a summer seminar at Dartmouth for about 10 participants. In June, he and Claude Shannon, a founder of information theory then at Bell Labs, met with Robert Morison, Director of Biological and Medical Research to discuss the idea and possible funding, though Morison was unsure whether money would be made available for such a visionary project. On September 2, 1955, the project was formally proposed by McCarthy, Marvin Minsky, Nathaniel Rochester and Claude Shannon. The proposal is credited with introducing the term 'artificial intelligence'. The Proposal states: We propose that a 2-month, 10-man study of artificial intelligence be carried out during the summer of 1956 at Dartmouth College in Hanover, New Hampshire. The study is to proceed on the basis of the conjecture that every aspect of learning or any other feature of intelligence can in principle be so precisely described that a machine can be made to simulate it. An attempt will be made to find how to make machines use language, form abstractions and concepts, solve kinds of problems now reserved for humans, and improve themselves. We think that a significant advance can be made in one or more of these problems if a carefully selected group of scientists work on it together for a summer. The proposal goes on to discuss computers, natural language processing, neural networks, theory of computation, abstraction and creativity (these areas within the field of artificial intelligence are considered still relevant to the work of the field). On May 26, 1956, McCarthy notified Robert Morison of the planned 11 attendees: For the full period: 1) Dr. Marvin Minsky 2) Dr. Julian Bigelow 3) Professor D.M. Mackay 4) Mr. Ray Solomonoff 5) Mr. John Holland 6) Dr. John McCarthy For four weeks: 7) Dr. Claude Shannon 8) Mr. Nathaniel Rochester 9) Mr. Oliver Selfridge For the first two weeks: 10) Dr. Allen Newell 11) Professor Herbert Simon He noted, "we will concentrate on a problem of devising a way of programming a calculator to form concepts and to form generalizations. This of course is subject to change when the group gets together." The actual participants came at different times, mostly for much shorter times. Trenchard More replaced Rochester for three weeks and MacKay and Holland did not attend—but the project was set to begin. Around June 18, 1956, the earliest participants (perhaps only Ray Solomonoff, maybe with Tom Etter) arrived at the Dartmouth campus in Hanover, N.H., to join John McCarthy who already had an apartment there. Solomonoff and Minsky stayed at Professors' apartments, but most would stay at the Hanover Inn. == Dates == The Dartmouth Workshop is usually said to have run for six weeks. Ray Solomonoff's notes taken during the workshop, however, indicate that it ran for roughly eight weeks, from about June 18 to August 17. Solomonoff's notes start on June 22; June 28 mentions Minsky, June 30 mentions Hanover, N.H., July 1 mentions Tom Etter. On August 17, Solomonoff gave a final talk. == Participants == Initially, McCarthy lost his list of attendees. Instead, after the workshop, McCarthy sent Solomonoff a preliminary list of participants and visitors plus those interested in the subject. 47 people were listed. Solomonoff, however, made a list of participants in his notes of the summer project: Ray Solomonoff Marvin Minsky John McCarthy Claude Shannon Trenchard More Nat Rochester Oliver Selfridge Julian Bigelow W. Ross Ashby W.S. McCulloch Abraham Robinson Tom Etter John Nash David Sayre Arthur Samuel Kenneth R. Shoulders Shoulders' friend Alex Bernstein Herbert Simon Allen Newell Shannon attended Solomonoff's talk on July 10 and Bigelow gave a talk on August 15. Solomonoff doesn't mention Bernard Widrow, but in 1994 Widrow said that he and an unidentified colleague from the same lab in MIT had attended for one week. In the same interview Widrow recalled that "I think [Wesley] Clark and [Belmont] Farley were there from Lincoln Lab." Trenchard mentions R. Culver and Solomonoff mentions Bill Shutz. Herb Gelernter didn't attend, but was influenced later by what Rochester learned. In an article in IEEE Spectrum, Grace Solomonoff additionally identifies Peter Milner in a photo taken by Nathaniel Rochester in front of Dartmouth Hall. Ray Solomonoff, Marvin Minsky, and John McCarthy were the only three who stayed for the full time. Trenchard took attendance during two weeks of his three-week visit. From three to about eight people would attend the daily sessions. == Event and aftermath == They had the entire top floor of the Dartmouth Math Department to themselves, and most weekdays they would meet at the main math classroom where someone might lead a discussion focusing on his ideas, or more frequently, a general discussion would be held. It was not a directed group research project; discussions covered many topics, but several directions are considered to have been initiated or encouraged by the Workshop: the rise of symbolic methods, systems focused on limited domains (early expert systems), and deductive systems versus inductive systems. One participant, Arthur Samuel, said, "It was very interesting, very stimulating, very exciting". Ray Solomonoff kept notes giving his impression of the talks and the ideas from various discussions. === McCarthy's 1956 AI distribution list === This is the list in the "People Interested in the Artificial Intelligence Problem" document which McCarthy produced in 1956, partly in lieu of a list of attendees at the Dartmouth workshop. According to McCarthy the list was "being sent to the people on the list and a few others", and its purpose was "to let those on it know who is interested in receiving documents on the problem" of artificial intelligence. McCarthy also promised to deliver them a report on the Dartmouth conference, and to send an updated list soon afterwards. It includes people who did not attend the conference and does not include everyone who did attend it.

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  History of artificial life

  Humans have considered and tried to create non-biological life for at least 3,000 years. As seen in tales ranging from Pygmalion to Frankenstein, humanity has long been intrigued by the concept of artificial life. == Pre-computer == The earliest examples of artificial life involve sophisticated automata constructed using pneumatics, mechanics, and/or hydraulics. The first automata were conceived during the third and second centuries BC and these were demonstrated by the theorems of Hero of Alexandria, which included sophisticated mechanical and hydraulic solutions. Many of his notable works were included in the book Pneumatics, which was also used for constructing machines until early modern times. In 1490, Leonardo da Vinci also constructed an armored knight, which is considered the first humanoid robot in Western civilization. Other early famous examples include al-Jazari's humanoid robots. This Arabic inventor once constructed a band of automata, which can be commanded to play different pieces of music. There is also the case of Jacques de Vaucanson's artificial duck exhibited in 1735, which had thousands of moving parts and one of the first to mimic a biological system. The duck could reportedly eat and digest, drink, quack, and splash in a pool. It was exhibited all over Europe until it fell into disrepair. In the late 1600s, following René Descartes' claims that animals could be understood as purely physical machines, there was increasing interest in the question of whether a machine could be designed that, like an animal, could generate offspring (a self-replicating machine). However, it wasn't until the invention of cheap computing power that artificial life as a legitimate science began in earnest, steeped more in the theoretical and computational than the mechanical and mythological. == 1950s–1970s == One of the earliest thinkers of the modern age to postulate the potentials of artificial life, separate from artificial intelligence, was math and computer prodigy John von Neumann. At the Hixon Symposium, hosted by Linus Pauling in Pasadena, California in the late 1940s, von Neumann delivered a lecture titled "The General and Logical Theory of Automata." He defined an "automaton" as any machine whose behavior proceeded logically from step to step by combining information from the environment and its own programming, and said that natural organisms would in the end be found to follow similar simple rules. He also spoke about the idea of self-replicating machines. He postulated a made-up of a control computer, a construction arm, and a long series of instructions, floating in a lake of parts. By following the instructions that were part of its own body, it could create an identical machine. He followed this idea by creating (with Stanislaw Ulam) a purely logic-based automaton, not requiring a physical body but based on the changing states of the cells in an infinite grid – the first cellular automaton. It was extraordinarily complicated compared to later CAs, having hundreds of thousands of cells which could each exist in one of twenty-nine states, but von Neumann felt he needed the complexity in order for it to function not just as a self-replicating "machine", but also as a universal computer as defined by Alan Turing. This "universal constructor" read from a tape of instructions and wrote out a series of cells that could then be made active to leave a fully functional copy of the original machine and its tape. Von Neumann worked on his automata theory intensively right up to his death, and considered it his most important work. Homer Jacobson illustrated basic self-replication in the 1950s with a model train set – a seed "organism" consisting of a "head" and "tail" boxcar could use the simple rules of the system to consistently create new "organisms" identical to itself, so long as there was a random pool of new boxcars to draw from. Edward F. Moore proposed "Artificial Living Plants", which would be floating factories which could create copies of themselves. They could be programmed to perform some function (extracting fresh water, harvesting minerals from seawater) for an investment that would be relatively small compared to the huge returns from the exponentially growing numbers of factories. Freeman Dyson also studied the idea, envisioning self-replicating machines sent to explore and exploit other planets and moons, and a NASA group called the Self-Replicating Systems Concept Team performed a 1980 study on the feasibility of a self-building lunar factory. University of Cambridge professor John Horton Conway invented the most famous cellular automaton in the 1960s. He called it the Game of Life, and publicized it through Martin Gardner's column in Scientific American magazine. Norwegian-Italian mathematician Nils Aall Barricelli, who worked mainly at US institutions, was a pioneer in computer based simulation of biological processes such as symbiogenesis and evolution. == 1970s–1980s == Philosophy scholar Arthur Burks, who had worked with von Neumann (and indeed, organized his papers after Neumann's death), headed the Logic of Computers Group at the University of Michigan. He brought the overlooked views of 19th century American thinker Charles Sanders Peirce into the modern age. Peirce was a strong believer that all of nature's workings were based on logic (though not always deductive logic). The Michigan group was one of the few groups still interested in alife and CAs in the early 1970s; one of its students, Tommaso Toffoli argued in his PhD thesis that the field was important because its results explain the simple rules that underlay complex effects in nature. Toffoli later provided a key proof that CAs were reversible, just as the true universe is considered to be. Christopher Langton was an unconventional researcher, with an undistinguished academic career that led him to a job programming DEC mainframes for a hospital. He became enthralled by Conway's Game of Life, and began pursuing the idea that the computer could emulate living creatures. After years of study, he began attempting to actualize Von Neumann's CA and the work of Edgar F. Codd, who had simplified Von Neumann's original twenty-nine state monster to one with only eight states. He succeeded in creating the first self-replicating computer organism in October 1979, using only an Apple II desktop computer. He entered Burks' graduate program at the Logic of Computers Group in 1982, at the age of 33, and helped to found a new discipline. Langton's official conference announcement of Artificial Life I was the earliest description of a field which had previously barely existed: Artificial life is the study of artificial systems that exhibit behavior characteristic of natural living systems. It is the quest to explain life in any of its possible manifestations, without restriction to the particular examples that have evolved on earth. This includes biological and chemical experiments, computer simulations, and purely theoretical endeavors. Processes occurring on molecular, social, and evolutionary scales are subject to investigation. The ultimate goal is to extract the logical form of living systems. Microelectronic technology and genetic engineering will soon give us the capability to create new life forms in silico as well as in vitro. This capacity will present humanity with the most far-reaching technical, theoretical and ethical challenges it has ever confronted. The time seems appropriate for a gathering of those involved in attempts to simulate or synthesize aspects of living systems. Ed Fredkin founded the Information Mechanics Group at MIT, which united Toffoli, Norman Margolus, and Charles Bennett. This group created a computer especially designed to execute cellular automata, eventually reducing it to the size of a single circuit board. This "cellular automata machine" allowed an explosion of alife research among scientists who could not otherwise afford sophisticated computers. In 1982, computer scientist named Stephen Wolfram turned his attention to cellular automata. He explored and categorized the types of complexity displayed by one-dimensional CAs, and showed how they applied to natural phenomena such as the patterns of seashells and the nature of plant growth. Norman Packard, who worked with Wolfram at the Institute for Advanced Study, used CAs to simulate the growth of snowflakes, following very basic rules. Computer animator Craig Reynolds similarly used three simple rules to create recognizable flocking behaviour in a computer program in 1987 to animate groups of boids. With no top-down programming at all, the boids produced lifelike solutions to evading obstacles placed in their path. Computer animation has continued to be a key commercial driver of alife research as the creators of movies attempt to find more realistic and inexpensive ways to animate natural forms such as plant life, animal movement, hair growth, and complicated org

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