Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.
Protocol engineering
Protocol engineering is the application of systematic methods to the development of communication protocols. It uses many of the principles of software engineering, but it is specific to the development of distributed systems. == History == When the first experimental and commercial computer networks were developed in the 1970s, the concept of protocols was not yet well developed. These were the first distributed systems. In the context of the newly adopted layered protocol architecture (see OSI model), the definition of the protocol of a specific layer should be such that any entity implementing that specification in one computer would be compatible with any other computer containing an entity implementing the same specification, and their interactions should be such that the desired communication service would be obtained. On the other hand, the protocol specification should be abstract enough to allow different choices for the implementation on different computers. It was recognized that a precise specification of the expected service provided by the given layer was important. It is important for the verification of the protocol, which should demonstrate that the communication service is provided if both protocol entities implement the protocol specification correctly. This principle was later followed during the standardization of the OSI protocol stack, in particular for the transport layer. It was also recognized that some kind of formalized protocol specification would be useful for the verification of the protocol and for developing implementations, as well as test cases for checking the conformance of an implementation against the specification. While initially mainly finite-state machine were used as (simplified) models of a protocol entity, in the 1980s three formal specification languages were standardized, two by ISO and one by ITU. The latter, called SDL, was later used in industry and has been merged with UML state machines. == Principles == The following are the most important principles for the development of protocols: Layered architecture: A protocol layer at the level n consists of two (or more) entities that have a service interface through which the service of the layer is provided to the users of the protocol, and which uses the service provided by a local entity of level (n-1). The service specification of a layer describes, in an abstract and global view, the behavior of the layer as visible at the service interfaces of the layer. The protocol specification defines the requirements that should be satisfied by each entity implementation. Protocol verification consists of showing that two (or more) entities satisfying the protocol specification will provide at their service interfaces the specified service of that layer. The (verified) protocol specification is used mainly for the following two activities: The development of an entity implementation. Note that the abstract properties of the service interface are defined by the service specification (and also used by the protocol specification), but the detailed nature of the interface can be chosen during the implementation process, separately for each entity. Test suite development for conformance testing. Protocol conformance testing checks that a given entity implementation conforms to the protocol specification. The conformance test cases are developed based on the protocol specification and are applicable to all entity implementations. Therefore standard conformance test suites have been developed for certain protocol standards. == Methods and tools == Tools for the activities of protocol verification, entity implementation and test suite development can be developed when the protocol specification is written in a formalized language which can be understood by the tool. As mentioned, formal specification languages have been proposed for protocol specification, and the first methods and tools where based on finite-state machine models. Reachability analysis was proposed to understand all possible behaviors of a distributed system, which is essential for protocol verification. This was later complemented with model checking. However, finite-state descriptions are not powerful enough to describe constraints between message parameters and the local variables in the entities. Such constraints can be described by the standardized formal specification languages mentioned above, for which powerful tools have been developed. It is in the field of protocol engineering that model-based development was used very early. These methods and tools have later been used for software engineering as well as hardware design, especially for distributed and real-time systems. On the other hand, many methods and tools developed in the more general context of software engineering can also be used of the development of protocols, for instance model checking for protocol verification, and agile methods for entity implementations. == Constructive methods for protocol design == Most protocols are designed by human intuition and discussions during the standardization process. However, some methods have been proposed for using constructive methods possibly supported by tools to automatically derive protocols that satisfy certain properties. The following are a few examples: Semi-automatic protocol synthesis: The user defines all message sending actions of the entities, and the tool derives all necessary reception actions (even if several messages are in transit). Synchronizing protocol: The state transitions of one protocol entity are given by the user, and the method derives the behavior of the other entity such that it remains in states that correspond to the former entity. Protocol derived from service specification: The service specification is given by the user and the method derives a suitable protocol for all entities. Protocol for control applications: The specification of one entity (called the plant - which must be controlled) is given, and the method derives a specification of the other entity such that certain fail states of the plant are never reached and certain given properties of the plant's service interactions are satisfied. This is a case of supervisory control. == Books == Ming T. Liu, Protocol Engineering, Advances in Computers, Volume 29, 1989, Pages 79–195. G.J. Holzmann, Design and Validation of Computer Protocols, Prentice Hall, 1991. H. König, Protocol Engineering, Springer, 2012. M. Popovic, Communication Protocol Engineering, CRC Press, 2nd Ed. 2018. P. Venkataram, S.S. Manvi, B.S. Babu, Communication Protocol Engineering, 2014.
Charge-coupled device
A charge-coupled device (CCD) is an integrated circuit containing an array of linked, or coupled, capacitors. Under the control of an external circuit, each capacitor can transfer its electric charge to a neighboring capacitor. CCD sensors are a major technology used in digital imaging. In a CCD image sensor, pixels are represented by p-doped metal–oxide–semiconductor (MOS) capacitors. These MOS capacitors, the basic building blocks of a CCD, are biased above the threshold for inversion when image acquisition begins, allowing the conversion of incoming photons into electron charges at the semiconductor-oxide interface; the CCD is then used to read out these charges. Although CCDs are not the only technology to allow for light detection, CCD image sensors are widely used in professional, medical, and scientific applications where high-quality image data are required. In applications with less exacting quality demands, such as consumer and professional digital cameras, active pixel sensors, also known as CMOS sensors (complementary MOS sensors), are generally used. However, the large quality advantage CCDs enjoyed early on has narrowed over time and since the late 2010s CMOS sensors are the dominant technology, having largely if not completely replaced CCD image sensors. == History == The basis for the CCD is the metal–oxide–semiconductor (MOS) structure, with MOS capacitors being the basic building blocks of a CCD, and a depleted MOS structure used as the photodetector in early CCD devices. In the late 1960s, Willard Boyle and George E. Smith at Bell Labs were researching MOS technology while working on semiconductor bubble memory. They realized that an electric charge was the analog of the magnetic bubble and that it could be stored on a tiny MOS capacitor. As it was fairly straightforward to fabricate a series of MOS capacitors in a row, they connected a suitable voltage to them so that the charge could be stepped along from one to the next. This led to the invention of the charge-coupled device by Boyle and Smith in 1969. They conceived of the design of what they termed, in their notebook, "Charge 'Bubble' Devices". The initial paper describing the concept in April 1970 listed possible uses as memory, a delay line, and an imaging device. The device could also be used as a shift register. The essence of the design was the ability to transfer charge along the surface of a semiconductor from one storage capacitor to the next. The first experimental device demonstrating the principle was a row of closely spaced metal squares on an oxidized silicon surface electrically accessed by wire bonds. It was demonstrated by Gil Amelio, Michael Francis Tompsett and George Smith in April 1970. This was the first experimental application of the CCD in image sensor technology, and used a depleted MOS structure as the photodetector. The first patent (U.S. patent 4,085,456) on the application of CCDs to imaging was assigned to Tompsett, who filed the application in 1971. The first working CCD made with integrated circuit technology was a simple 8-bit shift register, reported by Tompsett, Amelio and Smith in August 1970. This device had input and output circuits and was used to demonstrate its use as a shift register and as a crude eight pixel linear imaging device. Development of the device progressed at a rapid rate. By 1971, Bell researchers led by Michael Tompsett were able to capture images with simple linear devices. Several companies, including Fairchild Semiconductor, RCA and Texas Instruments, picked up on the invention and began development programs. Fairchild's effort, led by ex-Bell researcher Gil Amelio, was the first with commercial devices, and by 1974 had a linear 500-element device and a 2D 100 × 100 pixel device. Peter L. P. Dillon, a scientist at Kodak Research Labs, invented the first color CCD image sensor by overlaying a color filter array on this Fairchild 100 x 100 pixel Interline CCD starting in 1974. Steven Sasson, an electrical engineer working for the Kodak Apparatus Division, invented a digital still camera using this same Fairchild 100 × 100 CCD in 1975. The interline transfer (ILT) CCD device was proposed by L. Walsh and R. Dyck at Fairchild in 1973 to reduce smear and eliminate a mechanical shutter. To further reduce smear from bright light sources, the frame-interline-transfer (FIT) CCD architecture was developed by K. Horii, T. Kuroda and T. Kunii at Matsushita (now Panasonic) in 1981. The first KH-11 KENNEN reconnaissance satellite equipped with charge-coupled device array (800 × 800 pixels) technology for imaging was launched in December 1976. Under the leadership of Kazuo Iwama, Sony started a large development effort on CCDs involving a significant investment. Eventually, Sony managed to mass-produce CCDs for their camcorders. Before this happened, Iwama died in August 1982. Subsequently, a CCD chip was placed on his tombstone to acknowledge his contribution. The first mass-produced consumer CCD video camera, the CCD-G5, was released by Sony in 1983, based on a prototype developed by Yoshiaki Hagiwara in 1981. Early CCD sensors suffered from shutter lag. This was largely resolved with the invention of the pinned photodiode (PPD). It was invented by Nobukazu Teranishi, Hiromitsu Shiraki and Yasuo Ishihara at NEC in 1980. They recognized that lag can be eliminated if the signal carriers could be transferred from the photodiode to the CCD. This led to their invention of the pinned photodiode, a photodetector structure with low lag, low noise, high quantum efficiency and low dark current. It was first publicly reported by Teranishi and Ishihara with A. Kohono, E. Oda and K. Arai in 1982, with the addition of an anti-blooming structure. The new photodetector structure invented at NEC was given the name "pinned photodiode" (PPD) by B.C. Burkey at Kodak in 1984. In 1987, the PPD began to be incorporated into most CCD devices, becoming a fixture in consumer electronic video cameras and then digital still cameras. Since then, the PPD has been used in nearly all CCD sensors and then CMOS sensors. In January 2006, Boyle and Smith were awarded the National Academy of Engineering Charles Stark Draper Prize, and in 2009 they were awarded the Nobel Prize for Physics for their invention of the CCD concept. Michael Tompsett was awarded the 2010 National Medal of Technology and Innovation, for pioneering work and electronic technologies including the design and development of the first CCD imagers. He was also awarded the 2012 IEEE Edison Medal for "pioneering contributions to imaging devices including CCD Imagers, cameras and thermal imagers". == Basics of operation == In a CCD for capturing images, there is a photoactive region (an epitaxial layer of silicon), and a transmission region made out of a shift register (the CCD, properly speaking). An image is projected through a lens onto the capacitor array (the photoactive region), causing each capacitor to accumulate an electric charge proportional to the light intensity at that location. A one-dimensional array, used in line-scan cameras, captures a single slice of the image, whereas a two-dimensional array, used in video and still cameras, captures a two-dimensional picture corresponding to the scene projected onto the focal plane of the sensor. Once the array has been exposed to the image, a control circuit causes each capacitor to transfer its contents to its neighbor (operating as a shift register). The last capacitor in the array dumps its charge into a charge amplifier, which converts the charge into a voltage. By repeating this process, the controlling circuit converts the entire contents of the array in the semiconductor to a sequence of voltages. In a digital device, these voltages are then sampled, digitized, and usually stored in memory; in an analog device (such as an analog video camera), they are processed into a continuous analog signal (e.g. by feeding the output of the charge amplifier into a low-pass filter), which is then processed and fed out to other circuits for transmission, recording, or other processing. == Detailed physics of operation == === Charge generation === Before the MOS capacitors are exposed to light, they are biased into the depletion region; in n-channel CCDs, the silicon under the bias gate is slightly p-doped or intrinsic. The gate is then biased at a positive potential, above the threshold for strong inversion, which will eventually result in the creation of an n channel below the gate as in a MOSFET. However, it takes time to reach this thermal equilibrium: up to hours in high-end scientific cameras cooled at low temperature. Initially after biasing, the holes are pushed far into the substrate, and no mobile electrons are at or near the surface; the CCD thus operates in a non-equilibrium state called deep depletion. Then, when electron–hole pairs are generated in the depletion region, they are separated by the electric field, the elec
Software requirements
Software requirements for a system are the description of what the system should do, the service or services that it provides and the constraints on its operation. The IEEE Standard Glossary of Software Engineering Terminology defines a requirement as: A condition or capability needed by a user to solve a problem or achieve an objective A condition or capability that must be met or possessed by a system or system component to satisfy a contract, standard, specification, or other formally imposed document A documented representation of a condition or capability as in 1 or 2 The activities related to working with software requirements can broadly be broken down into elicitation, analysis, specification, and management. Note that the wording Software requirements is additionally used in software release notes to explain, which depending on software packages are required for a certain software to be built/installed/used. == Elicitation == Elicitation is the gathering and discovery of requirements from stakeholders and other sources. A variety of techniques can be used such as joint application design (JAD) sessions, interviews, document analysis, focus groups, etc. Elicitation is the first step of requirements development. == Analysis == Analysis is the logical breakdown that proceeds from elicitation. Analysis involves reaching a richer and more precise understanding of each requirement and representing sets of requirements in multiple, complementary ways. Requirements Triage or prioritization of requirements is another activity which often follows analysis. This relates to Agile software development in the planning phase, e.g. by Planning poker, however it might not be the same depending on the context and nature of the project and requirements or product/service that is being built. == Specification == Specification involves representing and storing the collected requirements knowledge in a persistent and well-organized fashion that facilitates effective communication and change management. Use cases, user stories, functional requirements, and visual analysis models are popular choices for requirements specification. == Validation == Validation involves techniques to confirm that the correct set of requirements has been specified to build a solution that satisfies the project's business objectives, and to detect and correct errors in the requirements before implementation. == Management == Requirements change during projects and there are often many of them. Management of this change becomes paramount to ensuring that the correct software is built for the stakeholders. == Tool support for Requirements Engineering == === Tools for Requirements Elicitation, Analysis and Validation === Taking into account that these activities may involve some artifacts such as observation reports (user observation), questionnaires (interviews, surveys and polls), use cases, user stories; activities such as requirement workshops (charrettes), brainstorming, mind mapping, role-playing; and even, prototyping; software products providing some or all of these capabilities can be used to help achieve these tasks. There is at least one author who advocates, explicitly, for mind mapping tools such as FreeMind; and, alternatively, for the use of specification by example tools such as Concordion. Additionally, the ideas and statements resulting from these activities may be gathered and organized with wikis and other collaboration tools such as Trello. The features actually implemented and standards compliance vary from product to product. === Tools for Requirements Specification === A Software requirements specification (SRS) document might be created using general-purpose software like a word processor or one of several specialized tools. Some of these tools can import, edit, export and publish SRS documents. It may help to make SRS documents while following a standardised structure and methodology, such as ISO/IEC/IEEE 29148:2018. Likewise, software may or not use some standard to import or export requirements (such as ReqIF) or not allow these exchanges at all. === Tools for Requirements Document Verification === Tools of this kind verify if there are any errors in a requirements document according to some expected structure or standard. === Tools for Requirements Comparison === Tools of this kind compare two requirement sets according to some expected document structure and standard. === Tools for Requirements Merge and Update === Tools of this kind allow the merging and update of requirement documents. === Tools for Requirements Traceability === Tools of this kind allow tracing requirements to other artifacts such as models and source code (forward traceability) or, to previous ones such as business rules and constraints (backwards traceability). === Tools for Model-Based Software or Systems Requirement Engineering === Model-based systems engineering (MBSE) is the formalised application of modelling to support system requirements, design, analysis, verification and validation activities beginning in the conceptual design phase and continuing throughout development and later lifecycle phases. It is also possible to take a model-based approach for some stages of the requirements engineering and, a more traditional one, for others. Very many combinations might be possible. The level of formality and complexity depends on the underlying methodology involved (for instance, i is much more formal than SysML and, even more formal than UML) === Tools for general Requirements Engineering === Tools in this category may provide some mix of the capabilities mentioned previously and others such as requirement configuration management and collaboration. The features actually implemented and standards compliance vary from product to product. There are even more capable or general tools that support other stages and activities. They are classified as ALM tools.
Lingua Libre
Lingua Libre is an online collaborative project and tool by the Wikimédia France association, which aims to build a collaborative, multilingual, audiovisual speech corpus under a free license. It mostly consists of a rapid recording online service which allows the user to chain hundreds of recordings. Contributors have produced content in 310+ languages. == Description == Lingua Libre enables the recording of words, phrases or sentences of any language, oral (audio recording) or signed (video recording). Words are presented to the speaker in the form of a list, created on the spot, in advance, or by reusing an existing Wikimedia category. The speaker simply reads the word displayed on the screen, and the software moves on to the next word when it detects a silence after the read word. This principle, borrowed from the open source software Shtooka recorder with the help of its creator, Nicolas Vion, makes it possible to record several hundreds of words per hour. The recordings are then uploaded automatically from the web client to the Wikimedia Commons media library. In spring 2021, Lingua Libre was offline due to a fire in Strasbourg, but no audio recordings were lost. === Use of the recordings === The recordings can be consulted either on Lingua Libre or on Commons. They are mainly used on other Wikimedia projects, for example to illustrate entries on Wiktionaries or proper nouns in Wikipedia articles. The re-use of the recordings in a language teaching context is envisaged. Language learners can freely download pronunciations and use them on GoldenDict, a popular dictionary software. Thus, audio recordings can be used as “Pronunciation Dictionaries” on GoldenDict without needing internet connection. The recordings are also reused in Natural Language Processing projects, for example to drive Mozilla's DeepSpeech speech recognition engines. == Versions == Lingua Libre was initiated on January 23, 2015 and has had three successive versions: === Lingua Libre v.1 (2016) === As part of the Languages of France project, which aims to document and promote the regional languages of France on Wikimedia and Internet projects in general, the conception of Lingua Libre started in November 2015, partly funded by the DGLFLF (General Delegation for the French language and the languages of France). The first version of the project was launched in August 2016. Only suitable for audio recording, Lingua Libre was shown during a workshop on Occitan language in December 2016, and then presented to the online Wikimedia community and at international events in 2017. === Lingua Libre v.2 (2018) === A complete rebuilding was launched at the end of 2017. The new version of Lingua Libre is based on MediaWiki, uses Wikibase and OAuth to better integrate into the Wikimedia environment. The interface is translated via Translatewiki.net so that the project can be used by a large number of communities. The new version of the site was ready in June 2018 and opened to the public in August 2018. === Lingua Libre v.2.2 (2020) === In 2020, important changes were made to the platform; a new look was developed especially for the site, the .org domain replaced the .fr domain used until then, and added support for sign languages through video recording. == Statistics == In the first two years of the project's launch, approximately 10,000 recordings were made. The transition to v.2 was accompanied by a sharp increase in the contributions. The number of recordings multiplied by 10 in less than a year, exceeding the 100,000 threshold in May 2019. These recordings were made by 127 speakers in almost 50 languages. By September 2020, the platform had more than 300,000 recordings in 90 languages with more than 350 speakers. The 500,000 recordings milestone was reached in June 2021, thanks to 540 speakers of 120 languages.
Mixed raster content
Mixed raster content (MRC) is a method for compressing images that contain both binary-compressible text and continuous-tone components, using image segmentation methods to improve the level of compression and the quality of the rendered image. By separating the image into components with different compressibility characteristics, the most efficient and accurate compression algorithm for each component can be applied. MRC-compressed images are typically packaged into a hybrid file format such as DjVu and sometimes PDF. This allows for multiple images, and the instructions to properly render and reassemble them, to be stored within a single file. Some image scanners optionally support MRC when scanning to PDF. A typical manual states that without MRC, the image is generated in a single process, with text and graphics not distinguished. With MRC, separate processes are used for text, graphics, and other elements, producing clearer graphics and sharper text, at the price of slightly slower processing. MRC is recommended to optimise the scanning of documents with harder-to-read text or lower-quality graphics. MRC can also reduce the size of the scanned file, though higher compression using JBIG2 can sometimes lead to character substitution errors in scanned documents. == File format == A form of MRC is defined by international standard bodies as ISO/IEC 16485, or ITU recommendation T.44 (accessible free of charge). It defines a file format with bilevel masks and two data layers in each "stripe" of the image. The mask can be encoded in ITU T.4, JBIG1, or JBIG2, while the images can be JPEG, JBIG1, or run-length encoded color. The format is loosely based on JPEG, with a APP13 segment registered for this purpose. It is not known whether this file format is actually used, as formats like DjVu and PDF have their own ways of defining layers and masks.
JDoodle
JDoodle is a cloud-based online integrated development environment and compiler platform that supports execution of source code in 70+ programming languages including Java, Python, C/C++, PHP, Ruby, Perl, HTML, and more. It provides zero‑setup code for compilation, execution, and sharing via a web browser interface. == Features == Provides real‑time collaboration and code embedding via shareable URLs and APIs Offers an integrated terminal interface supporting database engines such as MySQL and MongoDB. JDroid — AI‑assistant to generate code snippets, optimize code, and assist debugging. == Languages and frameworks supported ==