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Biopython

Biopython is an open-source collection of non-commercial Python modules for computational biology and bioinformatics. It makes robust and well-tested code easily accessible to researchers. Python is an object-oriented programming language and is a suitable choice for automation of common tasks. The availability of reusable libraries saves development time and lets researchers focus on addressing scientific questions. Biopython is constantly updated and maintained by a large team of volunteers across the globe. Biopython contains parsers for diverse bioinformatic sequence, alignment, and structure formats. Sequence formats include FASTA, FASTQ, GenBank, and EMBL. Alignment formats include Clustal, BLAST, PHYLIP, and NEXUS. Structural formats include the PDB, which contains the 3D atomic coordinates of the macromolecules. It has provisions to access information from biological databases like NCBI, Expasy, PBD, and BioSQL. This can be used in scripts or incorporated into their software. Biopython contains a standard sequence class, sequence alignment, and motif analysis tools. It also has clustering algorithms, a module for structural biology, and a module for phylogenetics analysis. == History == The development of Biopython began in 1999, and it was first released in July 2000. First "semi-complete" and "semi-stable" release was done in March 2001 and December 2002 respectively. It was developed during a similar time frame and with analogous goals to other projects that added bioinformatics capabilities to their respective programming languages, including BioPerl, BioRuby and BioJava. Early developers on the project included Jeff Chang, Andrew Dalke and Brad Chapman, though over 100 people have made contributions to date. In 2007, a similar Python project, namely PyCogent, was established. The initial scope of Biopython involved accessing, indexing and processing biological sequence files. The retrieved data from common biological databases will then be parsed into a python data structure. While this is still a major focus, over the following years added modules have extended its functionality to cover additional areas of biology. The key challenge in the design of parsers for bioinformatics file formats is the frequency at which the data formats change. This is due to inadequate curation of the structure of the data, and changes in the database contents. This problem is overcome by the application of a standard event-oriented parser design (see Key features and examples). As of version 1.77, Biopython no longer supports Python 2. The current stable release of Biopython version 1.85 was released on 15 January 2025. It only supports Python 3 and the recent releases of Biopython require NumPy (and not Numeric). == Design == Wherever possible, Biopython follows the conventions used by the Python programming language to make it easier for users familiar with Python. For example, Seq and SeqRecord objects can be manipulated via slicing, in a manner similar to Python's strings and lists. It is also designed to be functionally similar to other Bio projects, such as BioPerl. It is organized into modular sub-packages, e.g., Bio.Seq, Bio.Align, Bio.PDB, Bio.Entrez each of them useful in a different bioinformatics domain. It used principles, like encapsulation and polymorphism, notably in classes Seq, SeqRecord, and Bio.PDB.Structure. It can also interoperate with other Python tools (Pandas, Matplotlib and SciPy). Biopython can read and write most common file formats for each of its functional areas, and its license is permissive and compatible with most other software licenses, which allows Biopython to be used in a variety of software projects. == Requirements == Biopython is currently supported and tested with the following Python implementations: Python 3 or PyPy3 NumPy == Key features and examples == === Input and output === Biopython can read and write to a number of common formats. When reading files, descriptive information in the file is used to populate the members of Biopython classes, such as SeqRecord. This allows records of one file format to be converted into others. Very large sequence files can exceed a computer's memory resources, so Biopython provides various options for accessing records in large files. They can be loaded entirely into memory in Python data structures, such as lists or dictionaries, providing fast access at the cost of memory usage. Alternatively, the files can be read from disk as needed, with slower performance but lower memory requirements. === Sequences === A core concept in Biopython is the biological sequence, and this is represented by the Seq class. A Biopython Seq object is similar to a Python string in many respects: it supports the Python slice notation, can be concatenated with other sequences and is immutable. This object includes both general string-like and biological sequence-specific methods. It is best to store information about the biological type (DNA, RNA, protein) separately from the sequence, rather than using an explicit alphabet argument. === Sequence annotation === The SeqRecord class describes sequences, along with information such as name, description and features in the form of SeqFeature objects. Each SeqFeature object specifies the type of the feature and its location. Feature types can be ‘gene’, ‘CDS’ (coding sequence), ‘repeat_region’, ‘mobile_element’ or others, and the position of features in the sequence can be exact or approximate. === Accessing online databases === Through the Bio.Entrez module, users of Biopython can download biological data from NCBI databases. Each of the functions provided by the Entrez search engine is available through functions in this module, including searching for and downloading records. === Phylogeny === The Bio.Phylo module provides tools for working with and visualising phylogenetic trees. A variety of file formats are supported for reading and writing, including Newick, NEXUS and phyloXML. Common tree manipulations and traversals are supported via the Tree and Clade objects. Examples include converting and collating tree files, extracting subsets from a tree, changing a tree's root, and analysing branch features such as length or score. Rooted trees can be drawn in ASCII or using matplotlib (see Figure 1), and the Graphviz library can be used to create unrooted layouts (see Figure 2). === Genome diagrams === The GenomeDiagram module provides methods of visualising sequences within Biopython. Sequences can be drawn in a linear or circular form (see Figure 3), and many output formats are supported, including PDF and PNG. Diagrams are created by making tracks and then adding sequence features to those tracks. By looping over a sequence's features and using their attributes to decide if and how they are added to the diagram's tracks, one can exercise much control over the appearance of the final diagram. Cross-links can be drawn between different tracks, allowing one to compare multiple sequences in a single diagram. === Macromolecular structure === The Bio.PDB module can load molecular structures from PDB and mmCIF files, and was added to Biopython in 2003. The Structure object is central to this module, and it organises macromolecular structure in a hierarchical fashion: Structure objects contain Model objects which contain Chain objects which contain Residue objects which contain Atom objects. Disordered residues and atoms get their own classes, DisorderedResidue and DisorderedAtom, that describe their uncertain positions. Using Bio.PDB, one can navigate through individual components of a macromolecular structure file, such as examining each atom in a protein. Common analyses can be carried out, such as measuring distances or angles, comparing residues and calculating residue depth. === Population genetics === The Bio.PopGen module adds support to Biopython for Genepop, a software package for statistical analysis of population genetics. This allows for analyses of Hardy–Weinberg equilibrium, linkage disequilibrium and other features of a population's allele frequencies. This module can also carry out population genetic simulations using coalescent theory with the fastsimcoal2 program. === Wrappers for command line tools === Biopython previously included command-line wrappers for tools such as BLAST, Clustal, EMBOSS, and SAMtools. This option allowed users to run external tool commands from within the code using specialized Biopython classes. However, Bio.Application modules and their wrappers have deprecated and will be removed in future Biopython releases. The main reason for this is the high maintenance burden of updating them with the evolving external tools. The recommended approach is to directly construct and execute command-line tool commands using Python’s built-in subprocess module. This method provides flexibility and removes the dependency on the Biopython wrappers. subprocess is a native Python module useful for running ext
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Oversampled binary image sensor

An oversampled binary image sensor is an image sensor with non-linear response capabilities reminiscent of traditional photographic film. Each pixel in the sensor has a binary response, giving only a one-bit quantized measurement of the local light intensity. The response function of the image sensor is non-linear and similar to a logarithmic function, which makes the sensor suitable for high dynamic range imaging. == Working principle == Before the advent of digital image sensors, photography, for the most part of its history, used film to record light information. At the heart of every photographic film are a large number of light-sensitive grains of silver-halide crystals. During exposure, each micron-sized grain has a binary fate: Either it is struck by some incident photons and becomes "exposed", or it is missed by the photon bombardment and remains "unexposed". In the subsequent film development process, exposed grains, due to their altered chemical properties, are converted to silver metal, contributing to opaque spots on the film; unexposed grains are washed away in a chemical bath, leaving behind the transparent regions on the film. Thus, in essence, photographic film is a binary imaging medium, using local densities of opaque silver grains to encode the original light intensity information. Thanks to the small size and large number of these grains, one hardly notices this quantized nature of film when viewing it at a distance, observing only a continuous gray tone. The oversampled binary image sensor is reminiscent of photographic film. Each pixel in the sensor has a binary response, giving only a one-bit quantized measurement of the local light intensity. At the start of the exposure period, all pixels are set to 0. A pixel is then set to 1 if the number of photons reaching it during the exposure is at least equal to a given threshold q. One way to build such binary sensors is to modify standard memory chip technology, where each memory bit cell is designed to be sensitive to visible light. With current CMOS technology, the level of integration of such systems can exceed 109~1010 (i.e., 1 giga to 10 giga) pixels per chip. In this case, the corresponding pixel sizes (around 50~nm ) are far below the diffraction limit of light, and thus the image sensor is oversampling the optical resolution of the light field. Intuitively, one can exploit this spatial redundancy to compensate for the information loss due to one-bit quantizations, as is classic in oversampling delta-sigma converters. Building a binary sensor that emulates the photographic film process was first envisioned by Fossum, who coined the name digital film sensor (now referred to as a quanta image sensor). The original motivation was mainly out of technical necessity. The miniaturization of camera systems calls for the continuous shrinking of pixel sizes. At a certain point, however, the limited full-well capacity (i.e., the maximum photon-electrons a pixel can hold) of small pixels becomes a bottleneck, yielding very low signal-to-noise ratios (SNRs) and poor dynamic ranges. In contrast, a binary sensor whose pixels need to detect only a few photon-electrons around a small threshold q has much less requirement for full-well capacities, allowing pixel sizes to shrink further. == Imaging model == === Lens === Consider a simplified camera model shown in Fig.1. The λ 0 ( x ) {\displaystyle \lambda _{0}(x)} is the incoming light intensity field. By assuming that light intensities remain constant within a short exposure period, the field can be modeled as only a function of the spatial variable x {\displaystyle x} . After passing through the optical system, the original light field λ 0 ( x ) {\displaystyle \lambda _{0}(x)} gets filtered by the lens, which acts like a linear system with a given impulse response. Due to imperfections (e.g., aberrations) in the lens, the impulse response, a.k.a. the point spread function (PSF) of the optical system, cannot be a Dirac delta, thus, imposing a limit on the resolution of the observable light field. However, a more fundamental physical limit is due to light diffraction. As a result, even if the lens is ideal, the PSF is still unavoidably a small blurry spot. In optics, such diffraction-limited spot is often called the Airy disk, whose radius R a {\displaystyle R_{a}} can be computed as R a = 1.22 w f , {\displaystyle R_{a}=1.22\,wf,} where w {\displaystyle w} is the wavelength of the light and f {\displaystyle f} is the F-number of the optical system. Due to the lowpass (smoothing) nature of the PSF, the resulting λ ( x ) {\displaystyle \lambda (x)} has a finite spatial-resolution, i.e., it has a finite number of degrees of freedom per unit space. === Sensor === Fig.2 illustrates the binary sensor model. The s m {\displaystyle s_{m}} denote the exposure values accumulated by the sensor pixels. Depending on the local values of s m {\displaystyle s_{m}} , each pixel (depicted as "buckets" in the figure) collects a different number of photons hitting on its surface. y m {\displaystyle y_{m}} is the number of photons impinging on the surface of the m {\displaystyle m} th pixel during an exposure period. The relation between s m {\displaystyle s_{m}} and the photon count y m {\displaystyle y_{m}} is stochastic. More specifically, y m {\displaystyle y_{m}} can be modeled as realizations of a Poisson random variable, whose intensity parameter is equal to s m {\displaystyle s_{m}} , As a photosensitive device, each pixel in the image sensor converts photons to electrical signals, whose amplitude is proportional to the number of photons impinging on that pixel. In a conventional sensor design, the analog electrical signals are then quantized by an A/D converter into 8 to 14 bits (usually the more bits the better). But in the binary sensor, the quantizer is 1 bit. In Fig.2, b m {\displaystyle b_{m}} is the quantized output of the m {\displaystyle m} th pixel. Since the photon counts y m {\displaystyle y_{m}} are drawn from random variables, so are the binary sensor output b m {\displaystyle b_{m}} . === Spatial and temporal oversampling === If it is allowed to have temporal oversampling, i.e., taking multiple consecutive and independent frames without changing the total exposure time τ {\displaystyle \tau } , the performance of the binary sensor is equivalent to the sensor with same number of spatial oversampling under certain condition. It means that people can make trade off between spatial oversampling and temporal oversampling. This is quite important, since technology usually gives limitation on the size of the pixels and the exposure time. == Advantages over traditional sensors == Due to the limited full-well capacity of conventional image pixel, the pixel will saturate when the light intensity is too strong. This is the reason that the dynamic range of the pixel is low. For the oversampled binary image sensor, the dynamic range is not defined for a single pixel, but a group of pixels, which makes the dynamic range high. == Reconstruction == One of the most important challenges with the use of an oversampled binary image sensor is the reconstruction of the light intensity λ ( x ) {\displaystyle \lambda (x)} from the binary measurement b m {\displaystyle b_{m}} . Maximum likelihood estimation can be used for solving this problem. Fig. 4 shows the results of reconstructing the light intensity from 4096 binary images taken by single photon avalanche diodes (SPADs) camera. A better reconstruction quality with fewer temporal measurements and faster, hardware friendly implementation, can be achieved by more sophisticated algorithms.
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Quantum robotics

Quantum robotics is an interdisciplinary field that investigates the intersection of robotics and quantum mechanics. This field, in particular, explores the applications of quantum phenomena such as quantum entanglement within the realm of robotics. Examples of its applications include quantum communication in multi-agent cooperative robotic scenarios, the use of quantum algorithms in performing robotics tasks, and the integration of quantum devices (e.g., quantum detectors) in robotic systems. == Introduction == The free-space quantum communication between mobile platforms was proposed for reconfigurable quantum key distribution (QKD) applications using unmanned aerial vehicle (UAVs, a.k.a. drones) in 2017. This technology was later advanced in various aspects in mobile drone and vehicle platforms in several configurations such as drone-to-drone, drone-to-moving vehicle, and vehicle-to-vehicle systems. Some research has contributed to low-size, low-weight, and low-power quantum key distribution systems for small-form UAVs, the characterization of a polarization-based receiver for mobile free-space optical QKD, and optical-relayed entanglement distribution using drones as mobile nodes. The topic of free-space quantum communication between mobile platforms, initially developed to meet the need for free-space QKD and entanglement distribution using mobile nodes, was brought into the robotics domain as an emerging interdisciplinary mechatronics topic to investigate the interface between quantum technologies and the robotic systems domain. The main advantage of such integrated technology is the guaranteed security in communication between multi-agent and cooperative autonomous systems. Other advances are anticipated. == Quantum entanglement == According to quantum mechanics, entanglement occurs when more than one particle become connected. If the state of one particle changes then it will instantly change the state of other particles regardless of their distance. Entangled sensors do the same kind of work and achieve strong sensitivity. A group of quantum robots can measure magnetic fields, gravitational fields and other physical properties using entangled sensors with high rate of accuracy. Again the connection of one robot to other is increased (become strong) by quantum entanglement. == Quantum teleportation == Quantum teleportation is the transfer of quantum information (not physical objects). This is used in case of multi robot process. One robot is programmed with a complex quantum update. Then that robot can teleport that complex quantum information (the update) to other robots. This teleportation or communication is very secure because all the work is done in quantum state. == Kinematics == Quantum computing has been proposed as being optimal for calculating inverse kinematics values. == Alice and Bob robots == In the realm of quantum mechanics, the names Alice and Bob are frequently employed to illustrate various phenomena, protocols, and applications. These include their roles in QKD, quantum cryptography, entanglement, and teleportation. The terms "Alice Robot" and "Bob Robot" serve as analogous expressions that merge the concepts of Alice and Bob from quantum mechanics with mechatronic mobile platforms (such as robots, drones, and autonomous vehicles). For example, the Alice Robot functions as a transmitter platform that communicates with the Bob Robot, housing the receiving detectors.
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Avizo (software)

Avizo (pronounce: 'a-VEE-zo') is a general-purpose commercial software application for scientific and industrial data visualization and analysis. Avizo is developed by Thermo Fisher Scientific and was originally designed and developed by the Visualization and Data Analysis Group at Zuse Institute Berlin (ZIB) under the name Amira. Avizo was commercially released in November 2007. For the history of its development, see the Wikipedia article about Amira. == Overview == Avizo is a software application which enables users to perform interactive visualization and computation on 3D data sets. The Avizo interface is modelled on the visual programming. Users manipulate data and module components, organized in an interactive graph representation (called Pool), or in a Tree view. Data and modules can be interactively connected together, and controlled with several parameters, creating a visual processing network whose output is displayed in a 3D viewer. With this interface, complex data can be interactively explored and analyzed by applying a controlled sequence of computation and display processes resulting in a meaningful visual representation and associated derived data. == Application areas == Avizo has been designed to support different types of applications and workflows from 2D and 3D image data processing to simulations. It is a versatile and customizable visualization tool used in many fields: Scientific visualization Materials Research Tomography, Microscopy, etc. Nondestructive testing, Industrial Inspection, and Visual Inspection Computer-aided Engineering and simulation data post-processing Porous medium analysis Civil Engineering Seismic Exploration, Reservoir Engineering, Microseismic Monitoring, Borehole Imaging Geology, Digital Rock Physics (DRP), Earth Sciences Archaeology Food technology and agricultural science Physics, Chemistry Climatology, Oceanography, Environmental Studies Astrophysics == Features == Data import: 2D and 3D image stack and volume data: from microscopes (electron, optical), X-ray tomography (CT, micro-/nano-CT, synchrotron), neutron tomography and other acquisition devices (MRI, radiography, GPR) Geometric models (such as point sets, line sets, surfaces, grids) Numerical simulation data (such as Computational fluid dynamics or Finite element analysis data) Molecular data Time series and animations Seismic data Well logs 4D Multivariate Climate Models 2D/3D data visualization: Volume rendering Digital Volume Correlation Visualization of sections, through various slicing and clipping methods Isosurface rendering Polygonal meshes Scalar fields, Vector fields, Tensor representations, Flow visualization (Illuminated Streamlines, Stream Ribbons) Image processing: 2D/3D Alignment of image slices, Image registration Image filtering Mathematical Morphology (erode, dilate, open, close, tophat) Watershed Transform, Distance Transform Image segmentation 3D models reconstruction: Polygonal surface generation from segmented objects Generation of tetrahedral grids Surface reconstruction from point clouds Skeletonization (reconstruction of dendritic, porous or fracture network) Surface model simplification Quantification and analysis: Measurements and statistics Analysis spreadsheet and charting Material properties computation, based on 3D images: Absolute permeability Thermal conductivity Molecular diffusivity Electrical resistivity/formation factor 3D image-based meshing for CFD and FEA: From 3D imaging modalities (CT, micro-CT, MRI, etc.) Surface and volume meshes generation Export to FEA and CFD solvers for simulation Post-processing for simulation analysis Presentation, automation: MovieMaker, Multiscreen, Video wall, collaboration, and VR support TCL Scripting, C++ extension API Avizo is based on Open Inventor 3D graphics toolkits (FEI Visualization Sciences Group).
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Abillion

abillion was a mobile application helping users to find vegan and sustainable products. The platform allowed users to review plant-based, cruelty-free and sustainable products, while donating between 0.10 and $1 to nonprofit organisations for each review written. As of May 2023, the company claimed to have donated over $2.8M to various nonprofit organisations including Sea Shepherd and Mercy for Animals. The main objective of the company was to reach the number of one billion people following a vegan diet and lifestyle by 2030. == History == The American entrepreneur Vikas Garg founded the company in Singapore and the app was officially launched in May 2018. The start-up was first named 'abillionveg' and changed its name in 2020 to shorten it to 'abillion'. In 2019, the company raised $3M in its first round of funding (pre-Series A). In 2021, it raised $10M in its Series A funding. In February 2023, the company announced the launch of a community investment round, using the crowdfunding platform Wefunder, which reached a total of $500 000. In May 2023, it celebrated its 5th anniversary and reaching 1M downloads. In March 2026, the company announced that they would be closing down by the end of the month. == Awards == Using data from the reviews published by its users, abillion was awarding the most liked vegan products and brands. In May 2023, the company published a world Top 10 Best Plant Based Burgers, among the winning brands were Beyond Meat, NotCo and Sojasun.
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The Drivers Cooperative

The Drivers Cooperative or Co-Op Ride is an American ridesharing company and mobile app that is a workers cooperative, owned collectively by the drivers. The cooperative launched in May 2021 in New York City, with the first 2,500 drivers issued their ownership certificates in a media event. The cooperative was co-founded by Grenadan immigrant and for hire vehicle driver Ken Lewis, labor organizer Erik Forman, and former Uber executive Alissa Orlando. Mohammad Hossen is the first member of the drivers' advisory board, which they plan to expand democratically as more drivers are onboarded. Other staff include software and industry veterans and in addition to co-founder Lewis, there are other drivers in management roles such as ex-driver and organizer David Alexis. The Co-Op Ride app is on the iOS and Android platforms and is built on Google Maps, Stripe, and Waze. By July, the app had been downloaded by 30,000 users and the number of drivers increased to 3,400, and by August there were 40,000 users. The cooperative is owned by the drivers themselves, and takes 15% from each ride for business overhead costs, as opposed to the 25% to 40% ride hail apps like Uber or Lyft take per ride. While being ultimately owned by the driver members, not by investors, the cooperative began with seed money from the Minnesota-based Community Development Financial Institution Shared Capital Cooperative, the local Lower East Side People's Federal Credit Union, and welcomed individual donations via crowdfunding in the form of revenue sharing debt on Wefunder. Each driver is a member of the cooperative and owns one share of the company and one vote in business and leadership decisions. In addition to a larger percentage of the fees per ride driven, each driver as a part-owner will also receive a share of the company's profits after loans and other expenses are paid, in the form of weighted dividends. The drivers use their own cars. The cooperative vets its owner-members further than what is already performed by the New York City Taxi and Limousine Commission (TLC), and gives a fixed price when a car is ordered and does not engage in surge pricing. The TLC imposed a minimum payrate for mobile app ridesharing companies operating in New York city in 2018. In 2021 that is $1.26 per mile which Uber and Lyft do not pay above; the cooperative pays a minimum mileage of $1.64. The cooperative intends to be able to set aside 10% of profits to community foundations and other non-profits and community organizations. The cooperative has engaged in advocacy around a policy agenda voted on by its members. Legislation to achieve this policy goal was introduced by State Senator Julia Salazar and Assemblymember Jessica González-Rojas, with the support of a coalition led by The Drivers Cooperative, United Auto Workers Region 9 and 9A, Sunrise Movement, New York Lawyers for the Public Interest, and New York Communities for Change.
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Automaton

An automaton ( ; pl.: automata or automatons) is a relatively self-operating machine or control mechanism designed to automatically follow a sequence of operations or respond to predetermined instructions. Some automata, such as bellstrikers in mechanical clocks, are designed to give the illusion to the casual observer that they are operating under their own power or will, like a mechanical robot. The term has long been commonly associated with automated puppets that resemble moving humans or animals, built to impress and/or to entertain people. Animatronics are a modern type of automata with electronics, often used for the portrayal of characters or creatures in films and in theme park attractions. == Etymology == The word automaton is the latinization of the Ancient Greek automaton (αὐτόματον), which means "acting of one's own will". It was first used by Homer to describe an automatic door opening, or automatic movement of wheeled tripods. It is more often used to describe non-electronic moving machines, especially those that have been made to resemble human or animal actions, such as the jacks on old public striking clocks, or the cuckoo and any other animated figures on a cuckoo clock. == History == === Ancient === There are many examples of automata in Greek mythology: Hephaestus created automata for his workshop; Talos was an artificial man of bronze; King Alkinous of the Phaiakians employed gold and silver watchdogs. According to Aristotle, Daedalus used quicksilver to make his wooden statue of Aphrodite move. In other Greek legends he used quicksilver to install voice in his moving statues. The automata in the Hellenistic world were intended as tools, toys, religious spectacles, or prototypes for demonstrating basic scientific principles. Numerous water-powered automata were built by Ktesibios, a Greek inventor and the first head of the Great Library of Alexandria; for example, he "used water to sound a whistle and make a model owl move. He had invented the world's first 'cuckoo clock'". This tradition continued in Alexandria with inventors such as the Greek mathematician Hero of Alexandria (sometimes known as Heron), whose writings on hydraulics, pneumatics, and mechanics described siphons, a fire engine, a water organ, the aeolipile, and a programmable cart. Philo of Byzantium was famous for his inventions. Complex mechanical devices are known to have existed in Hellenistic Greece, though the only surviving example is the Antikythera mechanism, the earliest known analog computer. The clockwork is thought to have come originally from Rhodes, where there was apparently a tradition of mechanical engineering; the island was renowned for its automata; to quote Pindar's seventh Olympic Ode: The animated figures stand Adorning every public street And seem to breathe in stone, or move their marble feet. However, the information gleaned from recent scans of the fragments indicate that it may have come from the colonies of Corinth in Sicily and implies a connection with Archimedes. According to Jewish legend, King Solomon used his wisdom to design a throne with mechanical animals which hailed him as king when he ascended it; upon sitting down an eagle would place a crown upon his head, and a dove would bring him a Torah scroll. It is also said that when King Solomon stepped upon the throne, a mechanism was set in motion. As soon as he stepped upon the first step, a golden ox and a golden lion each stretched out one foot to support him and help him rise to the next step. On each side, the animals helped the King up until he was comfortably seated upon the throne. In ancient China, a curious account of automata is found in the Lie Zi text, believed to have originated around 400 BCE and compiled around the fourth century CE. Within it there is a description of a much earlier encounter between King Mu of Zhou (1023–957 BCE) and a mechanical engineer known as Yan Shi, an 'artificer'. The latter proudly presented the king with a very realistic and detailed life-size, human-shaped figure of his mechanical handiwork: The king stared at the figure in astonishment. It walked with rapid strides, moving its head up and down, so that anyone would have taken it for a live human being. The artificer touched its chin, and it began singing, perfectly in tune. He touched its hand, and it began posturing, keeping perfect time...As the performance was drawing to an end, the robot winked its eye and made advances to the ladies in attendance, whereupon the king became incensed and would have had Yen Shih [Yan Shi] executed on the spot had not the latter, in mortal fear, instantly taken the robot to pieces to let him see what it really was. And, indeed, it turned out to be only a construction of leather, wood, glue and lacquer, variously coloured white, black, red and blue. Examining it closely, the king found all the internal organs complete—liver, gall, heart, lungs, spleen, kidneys, stomach and intestines; and over these again, muscles, bones and limbs with their joints, skin, teeth and hair, all of them artificial...The king tried the effect of taking away the heart, and found that the mouth could no longer speak; he took away the liver and the eyes could no longer see; he took away the kidneys and the legs lost their power of locomotion. The king was delighted. Other notable examples of automata include Archytas' dove, mentioned by Aulus Gellius. Similar Chinese accounts of flying automata are written of the 5th century BC Mohist philosopher Mozi and his contemporary Lu Ban, who made artificial wooden birds (ma yuan) that could successfully fly according to the Han Fei Zi and other texts. === Medieval === The manufacturing tradition of automata continued in the Greek world well into the Middle Ages. On his visit to Constantinople in 949 ambassador Liutprand of Cremona described automata in the emperor Theophilos' palace, including "lions, made either of bronze or wood covered with gold, which struck the ground with their tails and roared with open mouth and quivering tongue," "a tree of gilded bronze, its branches filled with birds, likewise made of bronze gilded over, and these emitted cries appropriate to their species" and "the emperor's throne" itself, which "was made in such a cunning manner that at one moment it was down on the ground, while at another it rose higher and was to be seen up in the air." Similar automata in the throne room (singing birds, roaring and moving lions) were described by Luitprand's contemporary the Byzantine emperor Constantine Porphyrogenitus, in his book De Ceremoniis (Perì tês Basileíou Tákseōs). In the mid-8th century, the first wind powered automata were built: "statues that turned with the wind over the domes of the four gates and the palace complex of the Round City of Baghdad". The "public spectacle of wind-powered statues had its private counterpart in the 'Abbasid palaces where automata of various types were predominantly displayed." Also in the 8th century, the Muslim alchemist, Jābir ibn Hayyān (Geber), included recipes for constructing artificial snakes, scorpions, and humans that would be subject to their creator's control in his coded Book of Stones. In 827, Abbasid caliph al-Ma'mun had a silver and golden tree in his palace in Baghdad, which had the features of an automatic machine. There were metal birds that sang automatically on the swinging branches of this tree built by Muslim inventors and engineers. The Abbasid caliph al-Muqtadir also had a silver and golden tree in his palace in Baghdad in 917, with birds on it flapping their wings and singing. In the 9th century, the Banū Mūsā brothers invented a programmable automatic flute player and which they described in their Book of Ingenious Devices. Al-Jazari described complex programmable humanoid automata amongst other machines he designed and constructed in the Book of Knowledge of Ingenious Mechanical Devices in 1206. His automaton was a boat with four automatic musicians that floated on a lake to entertain guests at royal drinking parties. His mechanism had a programmable drum machine with pegs (cams) that bump into little levers that operate the percussion. The drummer could be made to play different rhythms and drum patterns if the pegs were moved around. Al-Jazari constructed a hand washing automaton first employing the flush mechanism now used in modern toilets. It features a female automaton standing by a basin filled with water. When the user pulls the lever, the water drains and the automaton refills the basin. His "peacock fountain" was another more sophisticated hand washing device featuring humanoid automata as servants who offer soap and towels. Mark E. Rosheim describes it as follows: "Pulling a plug on the peacock's tail releases water out of the beak; as the dirty water from the basin fills the hollow base a float rises and actuates a linkage which makes a servant figure appear from behind a door under the peacock and offer soap.
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BeHafizh

BeHafizh is a mobile application to assist in the effort to memorize Qur'anic verses. The software runs on the Android operating system. This application was made by a team from Gadjah Mada University (UGM) consisting of Farid Amin Ridwanto, Rian Adam Rajagede and Alfian Try Putranto in order to participate in the National Student Musabaqoh Tilawatil Quran (MTQ) held at University of Indonesia (UI) on 1- August 8, 2015. This application then won a gold medal in the branch of Computer Application Design in the competition. == Features == === Audio Player === Audio player, paragraph can be played repeatedly, with pause, and can be done on a certain range of Quranic verses. === Memorization Test === Memorization testing continues users to improve their memorization. Memorization Recorders improves user's ability to recite Quran. === Colour indicators === === Achievements === === Reminders ===
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Crackme

A crackme is a small computer program designed to test a programmer's reverse engineering skills. Crackmes are made as a legal way to crack software, since no intellectual property is being infringed. == Description == Crackmes often incorporate protection schemes and algorithms similar to those used in proprietary software. However, they can sometimes be more challenging because they may use advanced packing or protection techniques, making the underlying algorithm harder to analyze and modify. == Keygenme == A keygenme is specifically designed for the reverser to not only identify the protection algorithm used in the application but also create a small key generator (keygen) in the programming language of their choice. Most keygenmes, when properly manipulated, can be made self-keygenning. For example, during validation, they might generate the correct key internally and compare it to the user's input. This allows the key generation algorithm to be easily replicated. Anti-debugging and anti-disassembly routines are often used to confuse debuggers or render disassembly output useless. Code obfuscation is also used to further complicate reverse engineering.
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Group of Governmental Experts on Lethal Autonomous Weapons Systems

The Group of Governmental Experts on Lethal Autonomous Weapons Systems, commonly known as the GGE on LAWS, refers to a group of governmental experts established under the framework of the Convention on Certain Conventional Weapons (CCW), a United Nations arms control framework. The group examines legal, ethical, societal and moral questions that arise from the increased use of autonomous robots to carry weapons and to be programmed to engage in combat in various situations that might arise, including battles between countries, or in patrolling border areas or sensitive areas, or other similar roles. As of 18 March 2025, the Convention on Certain Conventional Weapons had 128 High Contracting Parties. In the Geneva Conventions, the term "High Contracting Parties" refers to the states that have joined the conventions and are therefore bound to uphold them. Among the countries that have joined are states with tense relations or ongoing armed conflict with one another, including Russia and Ukraine, Israel and the State of Palestine, and Pakistan and Afghanistan. == Background == In 2013, the Meeting of State Parties to the Convention on Certain Conventional Weapons agreed on a mandate on lethal autonomous weapon systems and tasked its chairperson with convening an informal Meeting of Experts to discuss issues related to emerging technologies in the area of LAWS. Those informal Meetings of Experts were then held in 2014, 2015 and 2016, and their reports fed into subsequent meetings of the High Contracting Parties. At the Fifth CCW Review Conference in 2016, the High Contracting Parties decided to establish an open-ended Group of Governmental Experts on emerging technologies in the area of LAWS, building on the earlier expert meetings. Since then, the group has been reconvened annually. In 2023, the Meeting of the High Contracting Parties to the CCW decided that the GGE on LAWS would continue its work in 2024 and 2025. The group was tasked with developing, by consensus, elements of a possible instrument, without predetermining its form, as well as other measures addressing lethal autonomous weapon systems, drawing on existing CCW protocols, earlier recommendations, state proposals, and legal, military, and technological expertise. == 2024 == In 2024, the GGE met twice, and the group was chaired by Robert in den Bosch, the Netherlands' disarmament ambassador. The 2024 Meeting of the High Contracting Parties decided that the group would meet for 10 days in 2025, in two five-day sessions, and reaffirmed its mandate to continue work by consensus on possible elements of an instrument and other measures addressing lethal autonomous weapon systems. == 2025 == At its first 2025 session, held in Geneva from 3 to 7 March 2025, the Group of Governmental Experts on Lethal Autonomous Weapon Systems discussed revisions to the chair's rolling text. The text was structured into five sections, or "boxes", though delegates held differing views on whether headings were useful or appropriate. Broadly, the discussions covered the characterization of lethal autonomous weapon systems, the application of international humanitarian law, possible prohibitions and regulations, legal review, and questions of accountability and responsibility. At its second session, held from 1 to 5 September 2025, delegations continued work on the chair's rolling text, which set out elements of a possible instrument and was organized into five thematic "boxes". == 2026 == === Developments before the 2026 session === A few weeks before the meeting, autonomous weapons drew renewed attention when the United States pressured Anthropic to revise the terms of use for its AI model Claude. Anthropic prohibited the model's use for mass domestic surveillance and for fully autonomous weapons operating without human oversight, while reports also emerged that OpenAI had reached an agreement with the U.S. Department of War for the use of its AI models, reportedly stipulating that they would not independently direct autonomous weapons where human control was required. The U.S. military nevertheless continued to use Claude during its war on Iran, and there was increasing alarm about the use of AI-assisted semi-autonomous weapons in conflicts including those in Ukraine, Sudan, Gaza, and Iran. Before the start of the sessions, Robert in den Bosch, as chair, warned that progress was urgent because technological developments were moving quickly. At the same time, although states agreed that international humanitarian law applied to LAWS, specific internationally binding standards governing such systems remained largely absent. A key divide before the session was that Russia and the United States opposed new legally binding instruments, while other states argued that new rules were necessary. According to Robert in den Bosch, the talks could lead to new rules, amendments to an existing convention, or a new treaty. === First session === From 2 to 6 March 2026, the group held its penultimate session under the group's three-year mandate. Delegations discussed the chair's rolling draft text, circulated in December 2025, on elements of a possible instrument or other measures concerning lethal autonomous weapon systems. In revised text circulated by the chair on 5 March 2026, a lethal autonomous weapon system was characterized as "a functionally integrated combination of one or more weapons and technological components, that can identify, select, and engage a target, without intervention by a human operator in the execution of these tasks". The text was divided into five boxes to structure discussion. During the session, delegates conducted a first reading of the draft text, and the chair later circulated revised language for several sections. Informal consultations were also held. According to campaign groups and participating observers, support grew during the week for moving to negotiations on the basis of the rolling text, with more than 70 states said to support that step by the end of the session, though some participants warned that attempts to bridge differences risked blurring the group's core purpose. The International Committee of the Red Cross argued that the text should not only restate existing international humanitarian law, but also clarify how those rules apply to autonomous weapons and set out additional measures tailored to the specific challenges such systems raise. Stop Killer Robots likewise emphasized the need to preserve meaningful human judgment and control over increasingly autonomous systems. During the discussions, the U.S. delegation opposed the term "human control" and reportedly proposed the alternative phrase "good faith human judgment and care". Other delegations rejected that wording as too weak, while many states continued to insist that meaningful human control over weapon systems remained essential.
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Super app

A super app or super-app (also known as an everything app) is a mobile or web application that can provide multiple services including payment and instant messaging services, effectively becoming an all-encompassing, self-contained, commerce and communication online platform that embraces many aspects of personal and commercial life. Notable examples of super apps include Tencent's WeChat in China, Tata Neu in India, Grab in Southeast Asia and Max in Russia. For end users, a super app is an application that provides a set of core features while also giving access to independently developed miniapps. For app developers, a super app is an application integrated with the capabilities of platforms and ecosystems that allows third-parties to develop and publish miniapps. == History == The super app term was first used to describe WeChat when it combined the instant messaging service with the digital wallet function. Recognition of WeChat as a super app stems from its combination of messaging, payments, e-commerce, and much more within a single application, making it indispensable for many users. WeChat's establishment of the super app model has led companies like Meta to try to build similar applications outside of China. In India, Tata Group has announced that it is currently developing a super app named Tata Neu. Major Indian companies like Paytm, PhonePe, and ITC Maars also have apps in development that might constitute super apps. In Southeast Asia, Grab and Gojek lay claim to the super app classification despite lacking many of the features offered by WeChat. Accordingly, growth-stage companies like Shopee, Traveloka, and AirAsia have also expanded the range of services offered by their respective applications. == Notable examples == === Alipay === Alipay is a third-party mobile and online payment platform established in Hangzhou, China in February 2004 by Alibaba Group and its founder Jack Ma. It operates in association with Ant Group, an affiliate company of the Chinese Alibaba Group. === Gojek === Gojek is an Indonesian on-demand multiservice digital platform and fintech payment super app. Established in Jakarta in 2010, as a call center to connect consumers to courier delivery and two-wheeled ride-hailing services, it launched its mobile app in 2015 with four services: GoRide, GoSend, GoShop, and GoFood, which has since expanded to offer over 20 services. In 2021, it merged with another Indonesian unicorn, Tokopedia, forming the decacorn GoTo Gojek Tokopedia. === Grab === Grab is a Southeast Asian technology company headquartered in Singapore and Indonesia. Founded in 2012 as the MyTeksi app in Kuala Lumpur, Malaysia, it expanded the following year as GrabTaxi, before moving its headquarters to Singapore in 2014 and rebranding officially as Grab. In addition to ride-hailing and transportation services, the company's mobile app also offers food delivery and digital payment services. === Max === Max is a messenger from the Russian company VK, positioned as a super app. The application combines messaging, calls, and channels features with the integration of additional services: payments, miniapps, taxi ordering, deliveries, and other everyday services are available within a single interface. The goal is to unite communication and routine tasks in a unified ecosystem. === Tata Neu === Tata Neu is a multipurpose super app, developed in India by the Tata Group. It is the country's first super app. The app was launched to coincide with the start of a 2022 Indian Premier League cricket match. === WeChat === WeChat is a Chinese multipurpose instant messaging, social media and mobile payment app. First released in 2011, it became the world's largest standalone mobile app in 2018, with over 1 billion monthly active users. WeChat provides text messaging, hold-to-talk voice messaging, broadcast (one-to-many) messaging, video conferencing, video games, the sharing of photographs and videos and location sharing. === X === X is an American social network, originally known as Twitter from its launch through 2023. Prior to his acquisition of the service, new owner Elon Musk stated that he planned for Twitter to become an "everything app" known as "X"; in 2023, the service added an AI chatbot known as "Grok" as well as integrated job search tools known as "X Hiring". In January 2025, X announced its intent to offer a digital wallet service in the future. Later in the year, X revamped its direct messaging system as "Chat". == Criticism == Although apps that fit the super app classification can offer users a wider variety of services in comparison to single-purpose alternatives, internet regulators in regions such as the US and Europe have become more concerned about the overall power of the technology industry and have become more critical of companies developing such apps. In China, WeChat and other local firms have been ordered to open up their platforms to rivals by local regulators. There are also reports that suggest it might be difficult to replicate WeChat's super app model. This stems partly from the peaking of smartphone penetration rates in many regions worldwide, which has led to overcrowded app stores and tighter restrictions on targeted advertising as regulators assert more control over the companies. From a technical viewpoint, single-purpose apps are comparatively faster, more responsive and easier to navigate than super apps, which helps improve the overall user experience. Super-apps are also likelier to store larger amounts of personal data to facilitate the delivery of their services, so users run a greater risk of becoming victims of severe data breaches. In 2020, this unfolded with Tokopedia, which had the data of 91 million of its users stolen and shared by crackers. It has also been noted that a user who loses access to their account or is banned from a super app generally loses access to multiple real-life services and digital applications; the Chinese government has used this approach to penalize people who shared the photos of the Sitong Bridge protest.
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Video renderer

A video renderer is software that processes a video file and sends it sequentially to the video display controller card for display on a computer screen. An example of a video renderer, is the VMR-7 that was used by Microsoft's DirectShow. An example of a UNIX video renderer is the one container within GStreamer. Commonly used video renderers are: Enhanced Video Renderer VMR9 Renderless Haali's Video Renderer Madvr Video Renderer JRVR, a part of JRiver Media Center
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Lossless join decomposition

In database design, a lossless join decomposition is a decomposition of a relation r {\displaystyle r} into relations r 1 , r 2 {\displaystyle r_{1},r_{2}} such that a natural join of the two smaller relations yields back the original relation. This is central in removing redundancy safely from databases while preserving the original data. Lossless join can also be called non-additive. == Definition == A relation r {\displaystyle r} on schema R {\displaystyle R} decomposes losslessly onto schemas R 1 {\displaystyle R_{1}} and R 2 {\displaystyle R_{2}} if π R 1 ( r ) ⋈ π R 2 ( r ) = r {\displaystyle \pi _{R_{1}}(r)\bowtie \pi _{R_{2}}(r)=r} , that is r {\displaystyle r} is the natural join of its projections onto the smaller schemas. A pair ( R 1 , R 2 ) {\displaystyle (R_{1},R_{2})} is a lossless-join decomposition of R {\displaystyle R} or said to have a lossless join with respect to a set of functional dependencies F {\displaystyle F} if any relation r ( R ) {\displaystyle r(R)} that satisfies F {\displaystyle F} decomposes losslessly onto R 1 {\displaystyle R_{1}} and R 2 {\displaystyle R_{2}} . Decompositions into more than two schemas can be defined in the same way. == Criteria == A decomposition R = R 1 ∪ R 2 {\displaystyle R=R_{1}\cup R_{2}} has a lossless join with respect to F {\displaystyle F} if and only if the closure of R 1 ∩ R 2 {\displaystyle R_{1}\cap R_{2}} includes R 1 ∖ R 2 {\displaystyle R_{1}\setminus R_{2}} or R 2 ∖ R 1 {\displaystyle R_{2}\setminus R_{1}} . In other words, one of the following must hold: ( R 1 ∩ R 2 ) → ( R 1 ∖ R 2 ) ∈ F + {\displaystyle (R_{1}\cap R_{2})\to (R_{1}\setminus R_{2})\in F^{+}} ( R 1 ∩ R 2 ) → ( R 2 ∖ R 1 ) ∈ F + {\displaystyle (R_{1}\cap R_{2})\to (R_{2}\setminus R_{1})\in F^{+}} === Criteria for multiple sub-schemas === Multiple sub-schemas R 1 , R 2 , . . . , R n {\displaystyle R_{1},R_{2},...,R_{n}} have a lossless join if there is some way in which we can repeatedly perform lossless joins until all the schemas have been joined into a single schema. Once we have a new sub-schema made from a lossless join, we are not allowed to use any of its isolated sub-schema to join with any of the other schemas. For example, if we can do a lossless join on a pair of schemas R i , R j {\displaystyle R_{i},R_{j}} to form a new schema R i , j {\displaystyle R_{i,j}} , we use this new schema (rather than R i {\displaystyle R_{i}} or R j {\displaystyle R_{j}} ) to form a lossless join with another schema R k {\displaystyle R_{k}} (which may already be joined (e.g., R k , l {\displaystyle R_{k,l}} )). == Example == Let R = { A , B , C , D } {\displaystyle R=\{A,B,C,D\}} be the relation schema, with attributes A, B, C and D. Let F = { A → B C } {\displaystyle F=\{A\rightarrow BC\}} be the set of functional dependencies. Decomposition into R 1 = { A , B , C } {\displaystyle R_{1}=\{A,B,C\}} and R 2 = { A , D } {\displaystyle R_{2}=\{A,D\}} is lossless under F because R 1 ∩ R 2 = A {\displaystyle R_{1}\cap R_{2}=A} and we have a functional dependency A → B C {\displaystyle A\rightarrow BC} . In other words, we have proven that ( R 1 ∩ R 2 → R 1 ∖ R 2 ) ∈ F + {\displaystyle (R_{1}\cap R_{2}\rightarrow R_{1}\setminus R_{2})\in F^{+}} .
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Imaging phantom

An imaging phantom, or simply phantom (less commonly spelled fantom), is a specially designed object that is scanned or imaged in the field of medical imaging to evaluate, analyze, and tune the performance of various imaging devices. A phantom is more readily available and provides more consistent results than the use of a living subject or cadaver, while also avoiding direct risks to living subjects. Phantoms were originally employed in 2D x-ray–based imaging techniques such as radiography or fluoroscopy, but more recently phantoms with desired imaging characteristics have been developed for 3D techniques such as SPECT, MRI, CT, ultrasound, PET, and other imaging modalities. == Design == A phantom used to evaluate an imaging device should respond in a similar manner to how human tissues and organs would act in that specific imaging modality. For instance, phantoms made for 2D radiography may hold various quantities of x-ray contrast agents with similar x-ray absorbing properties (such as the attenuation coefficient) to normal tissue to tune the contrast of the imaging device or modulate the patient's exposure to radiation. In such a case, the radiography phantom would not necessarily need to have similar textures and mechanical properties since these are not relevant in x-ray imaging modalities. However, in the case of ultrasonography, a phantom with similar rheological and ultrasound scattering properties to real tissue would be essential, but x-ray absorbing properties would not be relevant. The term "phantom" describes an object that is designed to resemble human tissue and can be evaluated, analyzed or manipulated to study the performance of a medical device. Phantoms are created using a digital file that is rendered through magnetic resonance imaging (MRI) or computer-aided design (CAD). The digital files allow for quick modifications that are read by the 3D printer. The 3D printer will create the product in successive layers using polymeric materials. There are several types of phantoms including tissue-mimicking, radiological phantoms, dental phantoms, BOMABs (used to calibrate whole-body counters), and more.
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Voice search

Voice search, also called voice-enabled search, allows the user to use a voice to search the Internet, a website, or an app. In a broader definition, voice search includes open-domain keyword query on any information on the Internet, for example in Google Voice Search, Cortana, Siri and Amazon Echo. Voice search is often interactive, involving several rounds of interaction that allows a system to ask for clarification. Voice search is a type of dialog system. Voice search is not a replacement for typed search. Rather the search terms, experience and use cases can differ heavily depending on the input type. == Supported language == Language is the most essential factor for a system to understand, and provide the most accurate results of what the user searches. This covers across languages, dialects, and accents, as users want a voice assistant that both understands them and speaks to them understandably. While spoken and written languages differ, voice search should support natural spoken language instead of only transforming voice into text and doing a regular text search with the help speech recognition. For example, in typed search an eCommerce user can easily copy and paste an alphanumeric product code to search field, but when speaking the search terms can be very different, such as "show me the new Bluetooth headphones by Samsung". == How it works == The difference between text and voice search is not only the input type. The mechanism must include an automatic speech recognition (ASR) for input, but it can also include natural language understanding for natural spoken search queries such as "What's the population for the United States" It can include text-to-speech (TTS) or a regular display for output modalities. Users might sometimes be required to activate the search by using a wake word. Then, the search system will detect the language spoken by the user. It will then detect the keywords and context of the sentence. Lastly, the device will return results depending on its output. A device with a screen might display the results, while a device without a screen will speak them back to the searcher.
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