AI App How To Use

AI App How To Use — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

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  Managed private cloud

  Managed private cloud (also known as "hosted private cloud" or "single-tenant SaaS") refers to a principle in software architecture where a single instance of the software runs on a server, serves a single client organization (tenant), and is managed by a third party. The third-party provider is responsible for providing the hardware for the server and also for preliminary maintenance. This is in contrast to multitenancy, where multiple client organizations share a single server, or an on-premises deployment, where the client organization hosts its software instance. Managed private clouds also fall under the larger umbrella of cloud computing. == Adoption == The need for private clouds arose due to enterprises requiring a dedicated service and infrastructure for their cloud computing needs, such as for business-critical operations, improved security, and better control over their resources. Managed private cloud adoption is a popular choice among organizations. It has been on the rise due to enterprises requiring a dedicated cloud environment and preferring to avoid having to deal with management, maintenance, or future upgrade costs for the associated infrastructure and services. Such operational costs are unavoidable in on-premises private cloud data centers. == Advantages and challenges of managed private cloud == A managed private cloud cuts down on upkeep costs by outsourcing infrastructure management and maintenance to the managed cloud provider. It is easier to integrate an organization's existing software, services, and applications into a dedicated cloud hosting infrastructure which can be customized to the client's needs instead of a public cloud platform, whose hardware or infrastructure/software platform cannot be individualized to each client. Customers who choose a managed private cloud deployment usually choose them because of their desire for efficient cloud deployment, but also have the need for service customization or integration only available in a single-tenant environment. This chart shows the key benefits of the different types of deployments, and shows the overlap between these cloud solutions. This chart shows key drawbacks. Since deployments are done in a single-tenant environment, it is usually cost-prohibitive for small and medium-sized businesses. While server upkeep and maintenance are handled by the service provider, including network management and security, the client is charged for all such services. It is up to the potential client to determine if a managed private cloud solution aligns with their business objectives and budget. While the service provider maintains the upkeep of servers, network, and platform infrastructure, sensitive data is typically not stored on managed private clouds as it may leave business-critical information prone to breaches via third-party attacks on the cloud service provider. Common customizations and integrations include: Active Directory Single Sign-on Learning Management Systems Video Teleconferencing == Deployment strategies and service providers == Software companies have taken a variety of strategies in the Managed Private Cloud realm. Some software organizations have provided managed private cloud options internally, such as Microsoft. Companies that offer an on-premises deployment option, by definition, enable third-party companies to market Managed Private Cloud solutions. A few managed private cloud service providers are: Adobe Connect: Adobe Connect may be purchased for on-premises deployment, multi-tenant hosted deployment, managed private cloud as ACMS, or managed by third-party managed private cloud provider ConnectSolutions. Rackspace CenturyLink Microsoft licenses for Lync, SharePoint and Exchange may be purchased for on-premises deployment, a multi-tenant hosted deployment via Office 365, or managed by third-party cloud hosting from Azaleos, ConnectSolutions and others.

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  Clinical quality management system

  Clinical quality management systems (CQMS) are systems used in the life sciences sector (primarily in the pharmaceutical, biologics and medical device industries) designed to manage quality management best practices throughout clinical research and clinical study management. A CQMS system is designed to manage all of the documents, activities, tasks, processes, quality events, relationships, audits and training that must be administered and controlled throughout the life of a clinical trial. The premise of a CQMS is to bring together the activities led by two sectors of clinical research, Clinical Quality and Clinical Operations, to facilitate cross-functional activities to improve efficiencies and transparency and to encourage the use of risk mitigation and risk management practices at the clinical study level. Based on the principles of quality management systems (QMS) which are used in many industries to create a framework for defining and delivering quality outcomes, managing risk, and continual improvement. Many guidelines and governance bodies have been established to ensure a common approach within a given industry to a set of parameters used to identify the minimally acceptable standard for that industry. The pharmaceutical industry is no exception, with several trade groups (e.g. PhRMA, EFPIA, RQA, etc.) coming together to enhance collaboration. However, as noted by the Academy of Medical Sciences, there are increasingly complex and bureaucratic legal and ethical frameworks that innovators must work within to develop new medicines for patients. The historical pharmaceutical QMS applies primarily to good manufacturing practice as described in existing ISO (International Organization for Standardization) and ICH (International Committee on Harmonization) guidelines. "Good Manufacturing Practices (GMP) relate to quality control and quality assurance enabling companies in the pharmaceutical sector to minimize or eliminate instances of contamination, mix-ups, and errors. This in turn, protects the customer from purchasing a product which is ineffective or even dangerous." These standards have historically been applied to the manufacturing environment, appropriate to how they have been written. However, according to FDA as well as other regulatory bodies, "Implementation of ICH Q10 throughout the product lifecycle should facilitate innovation and continual improvement", implying that the same standards that apply to the manufacturing environment should also be applied to the clinical research space, earlier in the lifecycle of an investigational or marketed product. Accordingly, a CQMS is any system developed to apply these principles to clinical operations within an organization.

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  Lumpers and splitters

  Lumpers and splitters are opposing factions in any academic discipline that has to place individual examples into rigorously defined categories. The lumper–splitter problem occurs when there is the desire to create classifications and assign examples to them, for example, schools of literature, biological taxa, and so on. A "lumper" is a person who assigns examples broadly, judging that differences are not as important as signature similarities. A "splitter" makes precise definitions, and creates new categories to classify samples that differ in key ways. == Origin of the terms == The earliest known use of these terms was thought to be by Charles Darwin, in a letter to Joseph Dalton Hooker in 1857: "It is good to have hair-splitters & lumpers". But according to research done by the deputy director at NCSE, Glenn Branch, the credit is due to naturalist Edward Newman who wrote in 1845, "The time has arrived for discarding imaginary species, and the duty of doing this is as imperative as the admission of new ones when such are really discovered. The talents described under the respective names of 'hair-splitting' and 'lumping' are unquestionably yielding their power to the mightier power of Truth." They were then introduced more widely by George G. Simpson in his 1945 work The Principles of Classification and a Classification of Mammals. As he put it: splitters make very small units – their critics say that if they can tell two animals apart, they place them in different genera ... and if they cannot tell them apart, they place them in different species. ... Lumpers make large units – their critics say that if a carnivore is neither a dog nor a bear, they call it a cat. A later use can be found in the title of a 1969 paper "On lumpers and splitters ..." by the medical geneticist Victor McKusick. Reference to lumpers and splitters in the humanities appeared in a debate in 1975 between J. H. Hexter and Christopher Hill, in the Times Literary Supplement. It followed from Hexter's detailed review of Hill's book Change and Continuity in Seventeenth Century England, in which Hill developed Max Weber's argument that the rise of capitalism was facilitated by Calvinist Puritanism. Hexter objected to Hill's "mining" of sources to find evidence that supported his theories. Hexter argued that Hill plucked quotations from sources in a way that distorted their meaning. Hexter explained this as a mental habit that he called "lumping". According to him, "lumpers" rejected differences and chose to emphasise similarities. Any evidence that did not fit their arguments was ignored as aberrant. Splitters, by contrast, emphasised differences, and resisted simple schemes. While lumpers consistently tried to create coherent patterns, splitters preferred incoherent complexity. == Usage in various fields == === Biology === The categorisation and naming of a particular species should be regarded as a hypothesis about the evolutionary relationships and distinguishability of that group of organisms. As further information comes to hand, the hypothesis may be confirmed or refuted. Sometimes, especially in the past when communication was more difficult, taxonomists working in isolation have given two distinct names to individual organisms later identified as the same species. When two named species are agreed to be of the same species, the older species name is almost always retained dropping the newer species name honouring a convention known as "priority of nomenclature". This form of lumping is technically called synonymisation. Dividing a taxon into multiple, often new, taxa is called splitting. Taxonomists are often referred to as "lumpers" or "splitters" by their colleagues, depending on their personal approach to recognizing differences or commonalities between organisms. For example, the number of genera used in Pteridophyte Phylogeny Group I (PPG I) has proved controversial. PPG I uses 18 lycophyte and 319 fern genera. The earlier system put forward by Smith et al. (2006) had suggested a range of 274 to 312 genera for ferns alone. By contrast, the system of Christenhusz & Chase (2014) used 5 lycophyte and about 212 fern genera. The number of fern genera was further reduced to 207 in a subsequent publication. Defending PPG I, Schuettpelz et al. (2018) argue that the larger number of genera is a result of "the gradual accumulation of new collections and new data" and hence "a greater appreciation of fern diversity and ... an improved ability to distinguish taxa". They also argue that the number of species per genus in the PPG I system is already higher than in other groups of organisms (about 33 species per genus for ferns as opposed to about 22 species per genus for angiosperms) and that reducing the number of genera as Christenhusz and Chase propose yields the excessive number of about 50 species per genus for ferns. In response, Christenhusz and Chase (2018) argue that the excessive splitting of genera destabilises the usage of names and will lead to greater instability in future, and that the highly split genera have few if any characters that can be used to recognise them, making identification difficult, even to generic level. They further argue that comparing numbers of species per genus in different groups is "fundamentally meaningless". === History === In history, lumpers are those who tend to create broad definitions that cover large periods of time and many disciplines, whereas splitters want to assign names to tight groups of inter-relationships. Lumping tends to create a more and more unwieldy definition, with members having less and less mutually in common. This can lead to definitions which are little more than conventionalities, or groups which join fundamentally different examples. Splitting often leads to "distinctions without difference", ornate and fussy categories, and failure to see underlying similarities. For example, in the arts, "Romantic" can refer specifically to a period of German poetry roughly from 1780 to 1810, but would exclude the later work of Goethe, among other writers. In music it can mean every composer from Hummel through Rachmaninoff, plus many that came after. === Software modelling === Software engineering often proceeds by building models (sometimes known as model-driven architecture). A lumper is keen to generalise, and produces models with a small number of broadly defined objects. A splitter is reluctant to generalise, and produces models with a large number of narrowly defined objects. Conversion between the two styles is not necessarily symmetrical. For example, if error messages in two narrowly defined classes behave in the same way, the classes can be easily combined. But if some messages in a broad class behave differently, every object in the class must be examined before the class can be split. This illustrates the principle that "splits can be lumped more easily than lumps can be split". === Language classification === There is no agreement among historical linguists about what amount of evidence is needed for two languages to be safely classified in the same language family. For this reason, many proposed language families have had lumper–splitter controversies, including Altaic, Pama–Nyungan, Nilo-Saharan, and most of the larger families of the Americas. At a completely different level, the splitting of a mutually intelligible dialect continuum into different languages, or lumping them into one, is also an issue that continually comes up, though the consensus in contemporary linguistics is that there is no completely objective way to settle the question. Splitters regard the comparative method (meaning not comparison in general, but only reconstruction of a common ancestor or protolanguage) as the only valid proof of kinship, and consider genetic relatedness to be the question of interest. American linguists of recent decades tend to be splitters. Lumpers are more willing to admit techniques like mass lexical comparison or lexicostatistics, and mass typological comparison, and to tolerate the uncertainty of whether relationships found by these methods are the result of linguistic divergence (descent from common ancestor) or language convergence (borrowing). Much long-range comparison work has been from Russian linguists belonging to the Moscow School of Comparative Linguistics, most notably Vladislav Illich-Svitych and Sergei Starostin. In the United States, Greenberg and Ruhlen's work has been met with little acceptance from linguists. Earlier American linguists like Morris Swadesh and Edward Sapir also pursued large-scale classifications like Sapir's 1929 scheme for the Americas, accompanied by controversy similar to that today. === Religious studies === Paul F. Bradshaw suggests that the same principles of lumping and splitting apply to the study of early Christian liturgy. Lumpers, who tend to predominate in this field, try to find a single line of successive texts from the apostolic age to the

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  Dendral

  Dendral was a project in artificial intelligence (AI) of the 1960s, and the computer software expert system that it produced. Its primary aim was to study hypothesis formation and discovery in science. For that, a specific task in science was chosen: help organic chemists in identifying unknown organic molecules, by analyzing their mass spectra and using knowledge of chemistry. It was done at Stanford University by Edward Feigenbaum, Bruce G. Buchanan, Joshua Lederberg, and Carl Djerassi, along with a team of highly creative research associates and students. It began in 1964 and spans approximately half the history of AI research. The software program Dendral is considered the first expert system because it automated the decision-making process and problem-solving behavior of organic chemists. The project consisted of research on two main programs Heuristic Dendral and Meta-Dendral, and several sub-programs. It was written in the Lisp programming language, which was considered the language of AI because of its flexibility. Many systems were derived from Dendral, including MYCIN, MOLGEN, PROSPECTOR, XCON, and STEAMER. There are many other programs today for solving the mass spectrometry inverse problem, see List of mass spectrometry software, but they are no longer described as 'artificial intelligence', just as structure searchers. The name Dendral is an acronym of the term "Dendritic Algorithm". == Heuristic Dendral == Heuristic Dendral is a program that uses mass spectra or other experimental data together with a knowledge base of chemistry to produce a set of possible chemical structures that may be responsible for producing the data. A mass spectrum of a compound is produced by a mass spectrometer, and is used to determine its molecular weight, the sum of the masses of its atomic constituents. For example, the compound water (H2O), has a molecular weight of 18 since hydrogen has a mass of 1.01 and oxygen 16.00, and its mass spectrum has a peak at 18 units. Heuristic Dendral would use this input mass and the knowledge of atomic mass numbers and valence rules, to determine the possible combinations of atomic constituents whose mass would add up to 18. As the weight increases and the molecules become more complex, the number of possible compounds increases drastically. Thus, a program that is able to reduce this number of candidate solutions through the process of hypothesis formation is essential. New graph-theoretic algorithms were invented by Lederberg, Harold Brown, and others that generate all graphs with a specified set of nodes and connection-types (chemical atoms and bonds) -- with or without cycles. Moreover, the team was able to prove mathematically that the generator is complete, in that it produces all graphs with the specified nodes and edges, and that it is non-redundant, in that the output contains no equivalent graphs (e.g., mirror images). The CONGEN program, as it became known, was developed largely by computational chemists Ray Carhart, Jim Nourse, and Dennis Smith. It was useful to chemists as a stand-alone program to generate chemical graphs showing a complete list of structures that satisfy the constraints specified by a user. == Meta-Dendral == Meta-Dendral is a machine learning system that receives the set of possible chemical structures and corresponding mass spectra as input, and proposes a set of rules of mass spectrometry that correlate structural features with processes that produce the mass spectrum. These rules would be fed back to Heuristic Dendral (in the planning and testing programs described below) to test their applicability. Thus, "Heuristic Dendral is a performance system and Meta-Dendral is a learning system". The program is based on two important features: the plan-generate-test paradigm and knowledge engineering. === Plan-generate-test paradigm === The plan-generate-test paradigm is the basic organization of the problem-solving method, and is a common paradigm used by both Heuristic Dendral and Meta-Dendral systems. The generator (later named CONGEN) generates potential solutions for a particular problem, which are then expressed as chemical graphs in Dendral. However, this is feasible only when the number of candidate solutions is minimal. When there are large numbers of possible solutions, Dendral has to find a way to put constraints that rules out large sets of candidate solutions. This is the primary aim of Dendral planner, which is a “hypothesis-formation” program that employs “task-specific knowledge to find constraints for the generator”. Last but not least, the tester analyzes each proposed candidate solution and discards those that fail to fulfill certain criteria. This mechanism of plan-generate-test paradigm is what holds Dendral together. === Knowledge Engineering === The primary aim of knowledge engineering is to attain a productive interaction between the available knowledge base and problem solving techniques. This is possible through development of a procedure in which large amounts of task-specific information is encoded into heuristic programs. Thus, the first essential component of knowledge engineering is a large “knowledge base.” Dendral has specific knowledge about the mass spectrometry technique, a large amount of information that forms the basis of chemistry and graph theory, and information that might be helpful in finding the solution of a particular chemical structure elucidation problem. This “knowledge base” is used both to search for possible chemical structures that match the input data, and to learn new “general rules” that help prune searches. The benefit Dendral provides the end user, even a non-expert, is a minimized set of possible solutions to check manually. == Heuristics == A heuristic is a rule of thumb, an algorithm that does not guarantee a solution, but reduces the number of possible solutions by discarding unlikely and irrelevant solutions. The use of heuristics to solve problems is called "heuristics programming", and was used in Dendral to allow it to replicate in machines the process through which human experts induce the solution to problems via rules of thumb and specific information. Heuristics programming was a major approach and a giant step forward in artificial intelligence, as it allowed scientists to finally automate certain traits of human intelligence. It became prominent among scientists in the late 1940s through George Polya’s book, How to Solve It: A New Aspect of Mathematical Method. As Herbert A. Simon said in The Sciences of the Artificial, "if you take a heuristic conclusion as certain, you may be fooled and disappointed; but if you neglect heuristic conclusions altogether you will make no progress at all." == History == During the mid 20th century, the question "can machines think?" became intriguing and popular among scientists, primarily to add humanistic characteristics to machine behavior. John McCarthy, who was one of the prime researchers of this field, termed this concept of machine intelligence as "artificial intelligence" (AI) during the Dartmouth summer in 1956. AI is usually defined as the capacity of a machine to perform operations that are analogous to human cognitive capabilities. Much research to create AI was done during the 20th century. Also around the mid 20th century, science, especially biology, faced a fast-increasing need to develop a "man-computer symbiosis", to aid scientists in solving problems. For example, the structural analysis of myoglobin, hemoglobin, and other proteins relentlessly needed instrumentation development due to its complexity. In the early 1960s, Joshua Lederberg started working with computers and quickly became tremendously interested in creating interactive computers to help him in his exobiology research. Specifically, he was interested in designing computing systems to help him study alien organic compounds. Lederberg had been heading a team designing instruments for the Mars Viking lander to search for precursor molecules of life in samples of the Mars surface, using a mass spectrometer coupled with a minicomputer. As he was not an expert in either chemistry or computer programming, he collaborated with Stanford chemist Carl Djerassi to help him with chemistry, and Edward Feigenbaum with programming, to automate the process of determining chemical structures from raw mass spectrometry data. Feigenbaum was an expert in programming languages and heuristics, and helped Lederberg design a system that replicated the way Djerassi solved structure elucidation problems. They devised a system called Dendritic Algorithm (Dendral) that was able to generate possible chemical structures corresponding to the mass spectrometry data as an output. Dendral then was still very inaccurate in assessing spectra of ketones, alcohols, and isomers of chemical compounds. Thus, Djerassi "taught" general rules to Dendral that could help eliminate most of the "chemically implausible" structures, and p

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  Necrobotics

  Necrobotics is the practice of using biotic materials (or dead organisms) as robotic components. Necrobotics can serve as an alternative to mechanical components that are difficult to manufacture by using biological components designed by natural selection in order to exploit the highly developed selective design implemented in biological lifeforms via the process of evolution. In July 2022, researchers in the Preston Innovation Lab at Rice University in Houston, Texas published a paper in Advanced Science introducing the concept and demonstrating its capability by repurposing dead spiders as robotic grippers and applying pressurized air to activate their gripping arms. In April 2025 researchers at Shinshu University created a “bio-hybrid drone” using silk-worm moth antennae to detect the source of a smell. In November 2025 researchers at McGill University demonstrated the use of a mosquito proboscis as a fine nozzle in experimental 3D printing. Necrobotics utilizes the spider's organic hydraulic system and their compact legs to create an efficient and simple gripper system. The necrobotic spider gripper is capable of lifting small and light objects, thereby serving as an alternative to complex and costly small mechanical grippers. == Background == The main appeal of the spider's body in necrobotics is its compact leg mechanism and use of hydraulic pressure. The spider's anatomy utilizes a simple hydraulic (fluid) pressure system. Spider legs have flexor muscles that naturally constrict their legs when relaxed. A force is required to straighten and extend their legs, which spiders accomplish by pumping hemolymph fluid (blood) through their joints as a means of hydraulic pressure. It takes no external power to curl their legs due to their flexor muscles' natural curled state. In July 2022, researchers in the Preston Innovation Lab at Rice University published a paper detailing their experiments with the gripper. Although dead spiders no longer produce hemolymph, Te Faye Yap (lead author and mechanical engineering graduate) found that pumping air through a needle into the spider's cephalothorax (main body) accomplishes the same results as hemolymph. The original hydraulic (fluid) system is essentially converted into a pneumatic (air) system. == Fabrication == Obtain a spider Euthanize the spider using a cold temperature of around -4°C for 5-7 days Insert a 25 gauge hypodermic needle into the spider's cephalothorax (main body) Apply glue around the needle to form a seal and allow it to dry Connect a syringe or pump to the needle Extend the spider's legs by pumping air in == Testing and Data == === Internal Force Versus Gripping Force === The typical pressure in a resting spider's legs ranges from 4 kPa to 6.1 kPa. Researchers extended the legs by increasing the spider's internal pressure to 5.5 kPa. Pumping air into the body increases the internal pressure, causing the legs to expand. Pumping air out of the body decreases internal pressure, causing the legs to contract due to their flexor leg muscles. When the internal pressure decreases to 0 kPa, the gripper would be fully closed, allowing for the gripper to grasp objects. This action demonstrates that as internal pressure decreases, the gripping force increases. Inversely, when internal pressure increases, the gripping force decreases. By gripping individual weighted acetate beads, it is found that the necrobotic gripper achieves a maximum gripping force of 0.35 milinewtons. === Spider Weight Versus Gripping Force === To estimate the gripping forces of smaller and larger spiders, researchers created a plot to predict the gripping force relative to the size of the spider. The wolf spider's body weight is relatively equal to the gripping force of its legs. The mass of the gripper is 33.5 mg and can lift 1.3 times its body weight (43.6 mg or 0.35 mN). However, with larger spiders, the gripping force relative to body weight decreases. For example, a 200-gram goliath birdeater is predicted to lift 10% of its weight (20 grams or 196 mN). Though there is an inverse relationship between spider mass and gripping force, larger spiders exert greater gripping forces than smaller spiders. === Gripper Lifespan === The necrobotic gripper's functionality is entirely reliant on the structural integrity of the spider. If the spider were to break down easily and frequently, the gripper would not be practical. Using cyclic testing, a series of repeated actions, it is found that the necrobotic gripper can actuate 700 to 1000 times. After 1000 cycles, cracks begin forming on the membrane of the leg joints due to dehydration. Weakened and decomposing joints lead to frequent breakage and replacement, thereby serving as an obstacle in applying necrobotics to real-world scenarios. One theorized fix to this issue is applying beeswax or a lubricant to the joints. Researchers found that over 10 days, the mass of an uncoated spider decreased 17 times more than the mass of a spider coated with beeswax. Lubricating joints combats dehydration and slows the loss of organic material. == Constraints == With the usage of organic material, there is a higher chance of the component decomposing and breaking down as opposed to traditional mechanical systems. There may be additional work and management required to replace these grippers if they fail. Additionally, organic inconsistencies with the spiders will yield inaccurate results. Not all wolf spiders develop the same, so gripping force and leg contraction can vary between grippers. There are moral implications behind euthanizing spiders for robotics. The ethical boundaries that necrobotics push in the pursuit of biohybrid systems raise concerns, as opponents say it may lead to the hybridization of mammals and is intrusive to nature. Proponents respond that repurposing dead animals has been human practice for millennia and that necrobotics should be pursued to advance science.

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  Mittens (chess)

  Mittens is a chess engine developed by Chess.com. It was released on January 1, 2023, alongside four other engines, all of them given cat-related names. The engine became a viral sensation in the chess community due to exposure through content made by chess streamers and a social media marketing campaign, later contributing to record levels of traffic to the Chess.com website and causing issues with database scalability. Mittens was given a rating of one point by Chess.com, although it was evidently stronger than that. Various chess masters played matches against the engine, with players such as Hikaru Nakamura and Levy Rozman drawing and losing their games respectively. A month after its release, Mittens was removed from the website on February 1, as expected through Chess.com's monthly bot cycles. In December 2023, Mittens was brought back in a group of Chess.com's most popular bots of 2023. In January 2024, Mittens was removed again. == Release == Mittens was released on January 1, 2023, as part of a New Year event on Chess.com. It was one of five engines released, all with names related to cats. The other engines released were named Scaredy Cat, rated 800; Angry Cat, rated 1000; Mr. Grumpers, rated 1200 and Catspurrov (a pun on Garry Kasparov), rated 1400. As part of the announcement, a picture of each engine was accompanied by a short description of its character. The description given for Mittens suggested that the engine was hiding something, reading: Mittens likes chess… But how good is she? Of the five engines released, Mittens was by far the most popular. In December 2023, Chess.com re-released Mittens as part of a "best of 2023" group of chess bots made to showcase their most popular bots of the year. == Design == Mittens was conceptualized by Chess.com employee Will Whalen. Appearing as a kitten, Mittens trash talked its opponents with a selection of voice lines: these lines included quotes from J. Robert Oppenheimer, Vincent van Gogh and Friedrich Nietzsche, as well as the 1967 film Le Samouraï. The engine's "personality" was devised by a writing team headed by Sean Becker, and Marija Casic provided the engine's graphics. Chess.com did not disclose any information about the software running the engine. It may be based on Chess.com's Komodo Dragon 3 engine. Mittens' strategy was to slowly grind down an opponent, a tactic likened to the playing style of Anatoly Karpov. Becker stated that the design team believed it would be "way more demoralizing and funny" for the engine to play this way. According to Hikaru Nakamura, Mittens sometimes missed the best move (or winning positions). == Rating == On Chess.com, Mittens had a rating of one point. However, the engine's playing style and tactics showed that it was stronger than that; Mittens was able to beat or draw against many top human players. In an interview with CNN Business, Whalen stated that the idea behind giving Mittens a rating of one was to surprise its opponents, giving it the upper hand psychologically. Estimates of Mittens' true rating range from an Elo of 3200 to 3500, because of its ability to beat other engines of around that level. An upper bound of the engine's rating was found after Levy Rozman made Mittens play against Stockfish 15, a 3700 rated engine. Mittens lost the two games that the engines played. The range of Mittens' possible ratings was summarized by Dot Esports, who stated: It seems like she’s around the 3200–3500 rating range (in Chess.com terms, where the best human players, like Magnus Carlsen and Hikaru Nakamura, sport a 3000–3100 rating in the faster formats), as evidenced by her victories over the site’s otherwise strongest, 3200-rated bots, and her defeat to Stockfish 15, which is currently rated around 3700. == Games == Against human players, Mittens won over 99 percent of the millions of games it played. Chess players such as Hikaru Nakamura, Benjamin Bok, Levy Rozman and Eric Rosen struggled against Mittens; while Rozman and Rosen both lost against the engine, Nakamura and Bok were both able to make a draw. In particular, Nakamura's game against the engine lasted 166 moves; he was playing as White. Bok, Benjamin Finegold and Rozman later went on to win against Mittens, the latter with engine assistance from Stockfish. Magnus Carlsen publicly refused to play the engine, calling it a "transparent marketing trick" and "a soulless computer". Against other chess engines, Mittens participated in the Chess.com Computer Chess Championship as a side act. In the competition, Mittens played 150 games against an engine named after the film M3GAN and won overall with a score of 81.5 to 68.5. This equated to 54 percent of the games played. During the event, an estimate of Mittens' rating was made at 3515 points. == Impact == Mittens went viral in the chess community due to its concept and design: according to an announcement by Chess.com, a combined total of 120 million games were played against the cat engines over the course of January, with around 40 million played against Mittens. The popularity of the engine was helped by the social media exposure created by Chess.com. This included creating an official Twitter account to promote the engine. Chess streamers like Rozman and Nakamura helped cultivate this by creating content around the engine. A video by Nakamura entitled "Mittens the chess bot will make you quit chess" gained over 3.5 million views on YouTube. On January 11, Chess.com reported issues with database scalability due to record levels of traffic: 40 percent more games had been played on Chess.com in January 2023 than any other month since the website's release. According to The Wall Street Journal, the popularity spike was more than the similar surge following the release of Netflix's The Queen's Gambit. The popularity of Mittens was cited by Chess.com as a reason for this instability. The problems continued throughout January; Chess.com stated that they would have to upgrade their servers and invest more in cloud computing to solve the problems caused by the website's popularity surge. On February 1, 2023, Mittens and the other cat engines were removed from the computer section of Chess.com. They were replaced with five new engines themed around artificial intelligence. A tweet was posted on the Mittens's Twitter account after the engine's removal, reading "This is just the beginning. Goodbye for now."

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  Ilya Sutskever

  Ilya Sutskever (Hebrew: איליה סוצקבר; born 1986) is a computer scientist who specializes in machine learning. He has made several major contributions to the field of deep learning, including sequence-to-sequence learning, reasoning models, GPT models, and contributions to CLIP, DALL-E, and AlphaGo. With Alex Krizhevsky and Geoffrey Hinton, he co-created AlexNet, a convolutional neural network. One of the most highly cited computer scientists in history, he has won the NeurIPS Test of Time Award for his lasting impact on AI research three times in a row (2022–2024) and received the National Academy of Sciences Award for the Industrial Application of Science in 2026. Sutskever co-founded and was chief scientist at OpenAI, where he oversaw the research breakthroughs that led to large language models and to the launch of ChatGPT. He also led the research that led to reasoning models such as o1. In 2023, he was one of the members of OpenAI's board that ousted Sam Altman as its CEO; Altman was reinstated a week later, and Sutskever stepped down from the board. In June 2024, Sutskever co-founded the company Safe Superintelligence Inc., alongside Daniel Gross and Daniel Levy. Within a year, the company was valued at more than $30 billion. == Early life and education == Sutskever was born in 1986 into a Jewish family in Nizhny Novgorod, Russia (then Gorky, Russian SFSR, Soviet Union). At the age of 5, he immigrated to Israel with his family and grew up in Jerusalem. Sutskever proved to be a good student in school, and in eighth grade started taking classes at the Open University of Israel. At 16, he moved with his family to Canada, where he attended high school for a month before being admitted to the University of Toronto in Ontario as a third-year undergraduate student. At the University of Toronto, Sutskever received a bachelor's degree in mathematics in 2005, a master's degree in computer science in 2007, and a PhD in computer science in 2013. His doctoral advisor was Geoffrey Hinton. In 2012, Sutskever built AlexNet in collaboration with Geoffrey Hinton and Alex Krizhevsky. == Career and research == In 2012, Sutskever spent about two months as a postdoc with Andrew Ng at Stanford University. He then returned to the University of Toronto and joined Hinton's new research company DNNResearch, a spinoff of Hinton's research group. In 2013, Google acquired DNNResearch and hired Sutskever as a research scientist at Google Brain. At Google Brain, Sutskever worked with Oriol Vinyals and Quoc Viet Le to create the sequence-to-sequence learning algorithm, and worked on TensorFlow. He is also one of the AlphaGo paper's many co-authors. At the end of 2015, Sutskever left Google to become cofounder and chief scientist of the newly founded organization OpenAI. In 2022, Sutskever tweeted, "it may be that today's large neural networks are slightly conscious", which triggered debates about AI consciousness. He is considered to have played a key role in the development of ChatGPT, and later in leading the research that led to reasoning models. He is credited with establishing OpenAI’s scaling ethos. In 2023, he announced that he would co-lead OpenAI's new "Superalignment" project, which was trying to solve the alignment of superintelligences within four years. He wrote that even if superintelligence seems far off, it could happen this decade. Sutskever was formerly one of the six board members of the nonprofit entity that controlled OpenAI. In November 2023, the board fired Sam Altman, saying that "he was not consistently candid in his communications with the board". He authored a 52-page memo that relied heavily on information from Mira Murati, accusing Altman of lying, manipulating executives, and fostering internal division. Sutskever submitted the memo to the board after months of tension and dissatisfaction with Altman's leadership style, and ultimately joined the board in voting for Altman's termination. In an all-hands company meeting shortly after the board meeting, Sutskever said that firing Altman was "the board doing its duty", but the next week, he expressed regret at having participated in Altman's ouster. Altman's firing and OpenAI's co-founder Greg Brockman's resignation led three senior researchers to resign from OpenAI. After that, Sutskever stepped down from the OpenAI board and was absent from OpenAI's office. Some sources suggested he was leading the team remotely, while others said he no longer had access to the team's work. In May 2024, Sutskever announced his departure from OpenAI to focus on a new project that was "very personally meaningful" to him. His decision followed a turbulent period at OpenAI marked by leadership crises and internal debates about the direction of AI development and alignment protocols. Jan Leike, the other leader of the superalignment project, announced his departure hours later, citing an erosion of safety and trust in OpenAI's leadership. In June 2024, Sutskever announced Safe Superintelligence Inc., a new company he founded with Daniel Gross and Daniel Levy with offices in Palo Alto and Tel Aviv. In contrast to OpenAI, which releases revenue-generating products, Sutskever said the new company's "first product will be the safe superintelligence, and it will not do anything else up until then". In September 2024, the company announced that it had raised $1 billion from venture capital firms including Andreessen Horowitz, Sequoia Capital, DST Global, and SV Angel. In March 2025, Safe Superintelligence Inc. raised $2 billion more and reportedly reached a $32 billion valuation, notably due to Sutskever's reputation. In June 2025, SSI rejected an offer from Meta Platforms to buy the company. Sutskever became CEO of SSI shortly thereafter, after co-founder and CEO Gross left for Meta. In an October 2024 interview after winning the Nobel Prize in Physics, Geoffrey Hinton expressed support for Sutskever's decision to fire Altman, emphasizing concerns about AI safety. During the Musk v. Altman trial in 2026, Sutskever confirmed he had a $7 billion stake in OpenAI. === Awards and honors === In 2015, Sutskever was named in MIT Technology Review's 35 Innovators Under 35. In 2018, he was the keynote speaker at Nvidia Ntech 2018 and AI Frontiers Conference 2018. In 2022, he was elected a Fellow of the Royal Society (FRS). In 2023 and 2024, included in Time's list of the 100 most influential people in AI In 2022, 2023, and 2024, he won Neural Information Processing Systems’ Test of Time award, which recognizes papers that significantly shaped the AI field over at least ten years. In 2025, he received an honorary doctorate from his alma mater, the University of Toronto In 2026, he received the National Academy of Sciences Award for the Industrial Application of Science, presented for the first time in artificial intelligence.

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  Kindwise

  FlowerChecker, also known as Kindwise, is a company that uses machine learning to identify natural objects from images. This includes plants and their diseases, but also insects and mushrooms. It is based in Brno, Czech Republic. It was founded in 2014 by Ondřej Veselý, Jiří Řihák, and Ondřej Vild, at the time Ph.D. students. == Features & Tools == FlowerChecker offers multiple products. Plant.id is a machine learning-based plant identification API launched in 2018, with the plant disease identification API, plant.health, released in April 2022. The plant.id API is suitable for integration into other software, such as mobile apps or urban trees from remote-sensing imagery. Other products include insect.id, mushroom.id and crop.health are machine learning-based identification APIs for the identification of insects, fungi and economically important plants, respectively, and include also online public demos. The FlowerChecker app was discontinued in October 2024 after 10 years of successful operation. == Recognition == In 2019, FlowerChecker won the Idea of the Year award in the AI Awards organized by the Confederation of Industry of the Czech Republic. In 2020, an academic study comparing ten free automated image recognition apps showed that plant.id's performance excelled in most of the parameters studied. In an independent study comparing different image-based species recognition models and their suitability for recognizing invasive alien species, the plant.id achieved the highest accuracy compared to other tools. In a subsequent study, plant.id was utilized to evaluate urban forest biodiversity using remote-sensing imagery, achieving the highest accuracy in tree species identification among compared methods. The technology has also been referenced as an example of practical integration of AI-based plant identification into cross-platform precision agriculture systems. == Research activities == Flowerchecker cooperates with the Nature Conservation Agency of the Czech Republic on a biodiversity mapping project. FlowerChecker plans to adapt its services to participate in the control of invasive species. In 2022, the company entered a consortium to develop a weeder capable of in-row weed detection and removal. In 2025, it received funding for the development of a technology for the removal of invasive species.

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  Apache Kudu

  Apache Kudu is a free and open source column-oriented data store of the Apache Hadoop ecosystem. It is compatible with most of the data processing frameworks in the Hadoop environment. It provides completeness to Hadoop's storage layer to enable fast analytics on fast data. The open source project to build Apache Kudu began as internal project at Cloudera. The first version Apache Kudu 1.0 was released 19 September 2016. == Comparison with other storage engines == Kudu was designed and optimized for OLAP workloads. Like HBase, it is a real-time store that supports key-indexed record lookup and mutation. Kudu differs from HBase since Kudu's datamodel is a more traditional relational model, while HBase is schemaless. Kudu's "on-disk representation is truly columnar and follows an entirely different storage design than HBase/Bigtable".

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  POSC Caesar

  POSC Caesar Association (PCA) is an international, open and not-for-profit, member organization that promotes the development of open specifications to be used as standards for enabling the interoperability of data, software and related matters. PCA is the initiator of ISO 15926 "Integration of life-cycle data for process plants including oil and gas production facilities" and is committed to its maintenance and enhancement. Nils Sandsmark has been the General Manager of POSC Caesar Association since 1999 and Thore Langeland, Norwegian Oil Industry Association (Norwegian: Oljeindustriens Landsforening, OLF), is the chairman of the board. == History == === Caesar Offshore === The first predecessor of POSC Caesar Association, the Caesar Offshore program, started in 1993. The original focus was on standardizing technical data definitions for capital intensive projects at the handover from the EPC contractor to the owner/operators of onshore and offshore oil and gas production facilities. The program was sponsored by The Research Council of Norway, two EPC contractors (Aker Maritime and Kværner), three owners/operators (Norsk Hydro, Saga Petroleum and Statoil) and DNV as service provider and project owner. === POSC Caesar project === During the period 1994–96, Caesar Offshore Program was defined as a project of Petrotechnical Open Software Corporation (POSC) (now Energistics), and changed its name to the POSC Caesar Project. In 1995 the project was joined by BP, Brown and Root and Elf Aquitaine and in 1997 by Intergraph, IBM, Oracle, Lloyd's, Shell, ABB and UMOE Technologies. During that time, POSC Caesar also became a member of European Process Industries STEP Technical Liaison Executive (EPISTLE) where it collaborates with PISTEP (UK), and USPI-NL (The Netherlands) on the development of ISO 10303, also known as "Standard for the Exchange of Product model data (STEP)". === POSC Caesar Association === In 1997, POSC Caesar Association was founded as an independent, global, non-profit, member organization. POSC Caesar Association serves an international membership and collaborates with other international organizations. It has its main office in Norway. Albeit the name of POSC Caesar Association still hints to its past as a project within the Petrotechnical Open Software Corporation (POSC) (now Energistics), from 1997 onwards, the organization has been independent. Energistics and POSC Caesar Association do collaborate, and are formally member in each other's organization. == Membership == POSC Caesar Association has with its current 36 members from around the world and has established an international footprint (with a strong membership in Norway) that includes a variety of backgrounds, from academia and solution providers to engineering contractors and owners/operators. The members are (subdivided by organization type): Associations: Energistics (USA) and The Norwegian Oil Industry Association (OLF, Norway); Universities and Research Institutes: International Research Institute of Stavanger (IRIS, Norway), Norwegian University of Science and Technology (NTNU, Norway), Korea Advanced Institute of Science and Technology (KAIST, Korea), SINTEF (Norway), University of Bergen (Norway), University of Oslo (Norway), University of Stavanger (Norway), University of Tromsø (Norway) and Western Norway Research Institute (Norway); Oil and Gas Companies: BP (UK), Petronas (Malaysia) and Statoil (Norway); Engineering contractors and consultants: Akvaplan-niva (Norway), Aker Solutions (Norway), Asset Life Cycle Information Management (ALCIM, Malaysia), CAESAR systems (USA), Bechtel (USA), Det Norske Veritas (DNV, Norway), Information Logic (USA) and iXIT Engineering Technology (Germany), Phusion IM Ltd (UK); Solution providers: Aveva (UK), Bentley Systems (USA), Jotne EPM Technology (Norway), Epsis (Norway), Eurostep (Sweden), International Business Machines Corporation (IBM, USA), Siemens - Comos Industry Solutions (before Innotec) (Germany), Intergraph (USA), Invenia (Norway), Keel Solution (Denmark), Noumenon (UK), NRX (Canada), Octaga (Norway) and Tektonisk (Norway). In general, the organization holds three membership meetings a year; one in January / February in North-America (typically USA), one in April / May in Europe (typically Norway) and one in October in Asia (typically Malaysia). == Activities and services == === Initiator and custodian of ISO 15926 === In consultation with the other EPISTLE members and the International Organization for Standardization (ISO), it was decided in 2003 (some say already in 1997) that for modeling-technical reasons it was better to discontinue the development of ISO 10303 and to initiate the development of ISO 15926 "Integration of life-cycle data for process plants including oil and gas production facilities." Over the years, the scope of the standard has increased from the initial capital-intensive projects in the upstream oil and gas industry, to include also relevant terminology for downstream oil and gas industry applications and to deal with real-time data related to the actual oil and gas production. ISO 15926 has also over the years evolved from a dictionary (a list of terms with definitions), over a taxonomy (added hierarchy) to an ontology (a formal representation of a set of concepts within a domain and the relationships between those concepts). ISO 15926 is therefore sometimes nicknamed the "Oil and Gas Ontology", for some considered to be an essential prerequisite together with Semantic Web technologies to get to better interoperability, an optimal use of all available data across boundaries and an increase in efficiency. This is what some call the next generation of Integrated Operations. === Reference data services === Placeholders: Flow scheme of WIP - RDS - ISO and role of SIGs RDS Standards in database pilot (ISO) === Special interest groups === Placeholders: Overview of SIGs Drilling and Completion Reservoir and Production Operations and Maintenance == Projects == There are a number of projects (co-)organized by POSC Caesar Association working on the extension of the ISO 15926 standard in different application areas. === Capital intensive projects application domain === The following projects are running at the moment (August 2009): The ADI Project of FIATECH, to build the tools (which will then be made available in the public domain) The IDS Project of POSC Caesar Association, to define product models required for data sheets A joint collaboration project between FIATECH POSC Caesar Association is the ADI-IDS project is the ISO 15926 WIP === Upstream oil and gas industry application domain === The following projects are currently running (August 2009): The Integrated Operations in the High North (IOHN) project is working on extending ISO 15926 to handle real-time data transmission and (pre-)processing to enable the next generation of Integrated Operations. The Environment Web project to include environmental reporting terms and definitions as used in EPIM's EnvironmentWeb in ISO 15926. Finalised projects include: The Integrated Information Platform (IIP) project working on establishing a real-time information pipeline based on open standards. It worked among others on: Daily Drilling Report (DDR) to including all terms and definitions in ISO 15926. This standard became mandatory on February 1, 2008 for reporting on the Norwegian Continental Shelf by the Norwegian Petroleum Directorate (NPD) and Safety Authority Norway (PSA). NPD says that the quality of the reports has improved considerably since. Daily Production Report (DPR) to including all terms and definitions in ISO 15926. This standard was tested successfully on the Valhall (BP-operated) and Åsgard (StatoilHydro-operated) fields offshore Norway. The terminology and XML schemata developed have also been included in Energistics’ PRODML standard. == Conferences and events == === Semantic Days === === Sogndal academic network meeting === == Collaborations == POSC Caesar is collaborating with a number of standardization bodies, including: Mimosa: collaboration on open information standards for Operations and Maintenance mainly for the downstream oil and gas industry; FIATECH: collaboration on open information standards for life cycle data of capital projects; Energistics: collaboration on information standards for the upstream oil and gas industry, including WITSML and PRODML; OASIS: collaboration on e-business standards; ISO TC184/SC4: the host of the ISO 15926 standard.

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  MultiNet

  Multilayered extended semantic networks (MultiNets) are both a knowledge representation paradigm and a language for meaning representation of natural language expressions that has been developed by Prof. Dr. Hermann Helbig on the basis of earlier Semantic Networks. It is used in a question-answering application for German called InSicht. It is also used to create a tutoring application developed by the university of University of Hagen to teach MultiNet to knowledge engineers. MultiNet is claimed to be one of the most comprehensive and thoroughly described knowledge representation systems. It specifies conceptual structures by means of about 140 predefined relations and functions, which are systematically characterized and underpinned by a formal axiomatic apparatus. Apart from their relational connections, the concepts are embedded in a multidimensional space of layered attributes and their values. Another characteristic of MultiNet distinguishing it from simple semantic networks is the possibility to encapsulate whole partial networks and represent the resulting conceptual capsule as a node of higher order, which itself can be an argument of relations and functions. MultiNet has been used in practical NLP applications such as natural language interfaces to the Internet or question answering systems over large semantically annotated corpora with millions of sentences. MultiNet is also a cornerstone of the commercially available search engine SEMPRIA-Search, where it is used for the description of the computational lexicon and the background knowledge, for the syntactic-semantic analysis, for logical answer finding, as well as for the generation of natural language answers. MultiNet is supported by a set of software tools and has been used to build large semantically based computational lexicons. The tools include a semantic interpreter WOCADI, which translates natural language expressions (phrases, sentences, texts) into formal MultiNet expressions, a workbench MWR+ for the knowledge engineer (comprising modules for automatic knowledge acquisition and reasoning), and a workbench LIA+ for the computer lexicographer supporting the creation of large semantically based computational lexica.

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  HTK (software)

  HTK (Hidden Markov Model Toolkit) is a proprietary software toolkit for handling HMMs. It is mainly intended for speech recognition, but has been used in many other pattern recognition applications that employ HMMs, including speech synthesis, character recognition and DNA sequencing. Originally developed at the Machine Intelligence Laboratory (formerly known as the Speech Vision and Robotics Group) of the Cambridge University Engineering Department (CUED), HTK is now being widely used among researchers who are working on HMMs.

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  Screen space directional occlusion

  Screen space directional occlusion (SSDO) is a computer graphics technique enhancing screen space ambient occlusion (SSAO) by taking direction into account to sample the ambient light (both the light coming directly at an object, as well as the light reflected off of the object directly behind it), to better approximate global illumination. SSDO was introduced by Tobias Ritschel, Thorsten Grosch, and Hans-Peter Seidel in their 2009 ACM Symposium on Interactive 3D Graphics and Games paper Approximating dynamic global illumination in image space, which describes it as extending SSAO to directional occlusion with one diffuse indirect bounce of light; later literature notes that SSDO still suffers from common screen-space artifacts such as noise and banding. == Method == The original SSDO paper describes a two-pass screen-space approach, with one pass for direct lighting and a second pass for indirect bounces. Later literature describes SSDO as assuming a general shadowing direction that allows color bleeding and a single light bounce.

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  Imageability

  Imageability is a measure of how easily a physical object, word or environment will evoke a clear mental image in the mind of any person observing it. It is used in architecture and city planning, in psycholinguistics, and in automated computer vision research. In automated image recognition, training models to connect images with concepts that have low imageability can lead to biased and harmful results. == History and components == Kevin A. Lynch first introduced the term, "imageability" in his 1960 book, The Image of the City. In the book, Lynch argues cities contain a key set of physical elements that people use to understand the environment, orient themselves inside of it, and assign it meaning. Lynch argues the five key elements that impact the imageability of a city are Paths, Edges, Districts, Nodes, and Landmarks. Paths: channels in which people travel. Examples: streets, sidewalks, trails, canals, railroads. Edges: objects that form boundaries around space. Examples: walls, buildings, shoreline, curbstone, streets, and overpasses. Districts: medium to large areas people can enter into and out of that have a common set of identifiable characteristics. Nodes: large areas people can enter, that serve as the foci of the city, neighborhood, district, etc. Landmarks: memorable points of reference people cannot enter into. Examples: signs, mountains and public art. In 1914, half a century before The Image of the City was published, Paul Stern discussed a concept similar to imageability in the context of art. Stern, in Susan Langer's Reflections on Art, names the attribute that describes how vividly and intensely an artistic object could be experienced apparency. == In computer vision == Automated image recognition was developed by using machine learning to find patterns in large, annotated datasets of photographs, like ImageNet. Images in ImageNet are labelled using concepts in WordNet. Concepts that are easily expressed verbally, like "early", are seen as less "imageable" than nouns referring to physical objects like "leaf". Training AI models to associate concepts with low imageability with specific images can lead to problematic bias in image recognition algorithms. This has particularly been critiqued as it relates to the "person" category of WordNet and therefore also ImageNet. Trevor Pagan and Kate Crawford demonstrated in their essay "Excavating AI" and their art project ImageNet Roulette how this leads to photos of ordinary people being labelled by AI systems as "terrorists" or "sex offenders". Images in datasets are often labelled as having a certain level of imageability. As described by Kaiyu Yang, Fei-Fei Li and co-authors, this is often done following criteria from Allan Paivio and collaborators' 1968 psycholinguistic study of nouns. Yang el.al. write that dataset annotators tasked with labelling imageability "see a list of words and rate each word on a 1-7 scale from 'low imagery' to 'high imagery'. To avoid biased or harmful image recognition and image generation, Yang et.al. recommend not training vision recognition models on concepts with low imageability, especially when the concepts are offensive (such as sexual or racial slurs) or sensitive (their examples for this category include "orphan", "separatist", "Anglo-Saxon" and "crossover voter"). Even "safe" concepts with low imageability, like "great-niece" or "vegetarian" can lead to misleading results and should be avoided.

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  GENESIS (software)

  GENESIS (The General Neural Simulation System) is a simulation environment for constructing realistic models of neurobiological systems at many levels of scale including: sub-cellular processes, individual neurons, networks of neurons, and neuronal systems. These simulations are “computer-based implementations of models whose primary objective is to capture what is known of the anatomical structure and physiological characteristics of the neural system of interest”. GENESIS is intended to quantify the physical framework of the nervous system in a way that allows for easy understanding of the physical structure of the nerves in question. “At present only GENESIS allows parallelized modeling of single neurons and networks on multiple-instruction-multiple-data parallel computers.” Development of GENESIS software spread from its home at Caltech to labs at the University of Texas at San Antonio, the University of Antwerp, the National Centre for Biological Sciences in Bangalore, the University of Colorado, the Pittsburgh Supercomputing Center, the San Diego Supercomputer Center, and Emory University. == Neurons and Neural Systems == GENESIS works by creating simulation environments for constructing models of neurons or neural systems. "Nerve cells are capable of communicating with each other in such a highly structured manner as to form neuronal networks. To understand neural networks, it is necessary to understand the ways in which one neuron communicates with another through synaptic connections and the process called synaptic transmission". Neurons have a specialized structure for their function, they "are different from most other cells in the body in that they are polarized and have distinct morphological regions, each with specific functions". The two important regions of a neuron are the dendrite and the axon. "Dendrites are the region where one neuron receives connections from other neurons. The cell body or soma contains the nucleus and the other organelles necessary for cellular function. The axon is a key component of nerve cells over which information is transmitted from one part of the neuron (e.g., the cell body) to the terminal regions of the neuron". The third important piece of a neuron is the synapse. "The synapse is the terminal region of the axon this is where one neuron forms a connection with another and conveys information through the process of synaptic transmission". Neural networks like the ones simulated with GENESIS software can quickly become highly complex and difficult to understand. "Just a few interconnected neurons (a microcircuit) can perform sophisticated tasks such as mediate reflexes, process sensory information, generate locomotion and mediate learning and memory. Even more complex networks, macrocircuits, consist of multiple embedded microcircuits. Macrocircuits mediate higher brain functions such as object recognition and cognition". GENESIS endeavors to simulate neural systems as they are found in nature. Often, "a neuron can receive contacts from up to 10,000 presynaptic neurons, and, in turn, any one neuron can contact up to 10,000 postsynaptic neurons. The combinatorial possibility could give rise to enormously complex neuronal circuits or network topologies, which might be very difficult to understand". == History == GENESIS was developed by Dr. James M. Bower, in the Caltech laboratory, and first released to the public in 1988 in association with the first Methods in Computational Neuroscience Course at the Marine Biological Laboratory in Woods Hole, MA. Full source code for the software was released in the same year under an open software model for development. It's now supported by the Computational Biology Initiative at the University of Texas at San Antonio and is available free along with tutorial guides on its use. P-GENESIS, a parallel version of GENESIS, was first run in 1990 on the Intel Delta, which was the prototype for the Intel Paragon family of massively parallel supercomputers. == How GENESIS Works == GENESIS is useful in creating a simulation environment for constructing models of neurobiological systems, such as: sub-cellular processes individual neurons networks of neurons neuronal systems The GENESIS system is complicated, but relatively easy to use. An individual can input commands through one of three ways: script files, graphical user interface, or the GENESIS command shell. These commands are then processed by the script language interpreter. "The Script Language Interpreter processes commands entered through the keyboard, script files, or the graphical user interface, and passes them to the GENESIS simulation engine. The simulation engine also loads compiled object libraries, reads and writes data files, and interacts with the graphical user interface". Below is a graphical representation of the user input process and a sample GENESIS output. == Applications == Most current applications for GENESIS involve realistic simulations of biological systems. It is usually used to simulate the behavior of larger brain structures, for example the cerebral cortex. These studies most often occur in lab courses in neural simulation at Caltech and the Marine Biological Laboratory at Woods Hole, Massachusetts. GENESIS can be used in combination with Yale University’s software called NEURON as a means for scientists to collaborate to construct a physical description of the nervous system. The GENESIS software can also be used with Kinetikit in the modeling of signal transduction pathways. GENESIS has been used in many studies. Some of these studies involve research that focuses on the development of software that would be useful across many disciplines. Others are studies of neurons, such as Purkinje cells. These studies used GENESIS to simulate Purkinje cells and could be useful for the planning and development of later experiments using the GENESIS software. There may also be biomedical applications of the software. For example, St. Jude Medical in Europe has developed an implanted GENESIS device.

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