Clinical quality management systems (CQMS) are systems used in the life sciences sector (primarily in the pharmaceutical, biologics and medical device industries) designed to manage quality management best practices throughout clinical research and clinical study management. A CQMS system is designed to manage all of the documents, activities, tasks, processes, quality events, relationships, audits and training that must be administered and controlled throughout the life of a clinical trial. The premise of a CQMS is to bring together the activities led by two sectors of clinical research, Clinical Quality and Clinical Operations, to facilitate cross-functional activities to improve efficiencies and transparency and to encourage the use of risk mitigation and risk management practices at the clinical study level. Based on the principles of quality management systems (QMS) which are used in many industries to create a framework for defining and delivering quality outcomes, managing risk, and continual improvement. Many guidelines and governance bodies have been established to ensure a common approach within a given industry to a set of parameters used to identify the minimally acceptable standard for that industry. The pharmaceutical industry is no exception, with several trade groups (e.g. PhRMA, EFPIA, RQA, etc.) coming together to enhance collaboration. However, as noted by the Academy of Medical Sciences, there are increasingly complex and bureaucratic legal and ethical frameworks that innovators must work within to develop new medicines for patients. The historical pharmaceutical QMS applies primarily to good manufacturing practice as described in existing ISO (International Organization for Standardization) and ICH (International Committee on Harmonization) guidelines. "Good Manufacturing Practices (GMP) relate to quality control and quality assurance enabling companies in the pharmaceutical sector to minimize or eliminate instances of contamination, mix-ups, and errors. This in turn, protects the customer from purchasing a product which is ineffective or even dangerous." These standards have historically been applied to the manufacturing environment, appropriate to how they have been written. However, according to FDA as well as other regulatory bodies, "Implementation of ICH Q10 throughout the product lifecycle should facilitate innovation and continual improvement", implying that the same standards that apply to the manufacturing environment should also be applied to the clinical research space, earlier in the lifecycle of an investigational or marketed product. Accordingly, a CQMS is any system developed to apply these principles to clinical operations within an organization.
Zolostays
Zolostays is a real-tech co-living focused startup that provides ready-to-move rooms/beds. It was founded in 2015 by Nikhil Sikri, Akhil Sikri and Sneha Choudhry. == Overview == During the pandemic, Zolo provided 75 of rent-free accommodation to those who lost their jobs. Zolo uses bulk inventory in usually residential township and ties up with real estate companies to make the rooms/beds available. Zolostays has both revenue sharing and leased model. == History == Zolostays was founded in 2015 to solve the problem of students and young professionals who would move to temporarily go to other cities to study and work and look for affordable housing. In 2020, it was operating in 10 Indian cities. It has four round of funding, with total $98 million.
Iterative reconstruction
Iterative reconstruction refers to iterative algorithms used to reconstruct 2D and 3D images in certain imaging techniques. For example, in computed tomography an image must be reconstructed from projections of an object. Here, iterative reconstruction techniques are usually a better, but computationally more expensive alternative to the common filtered back projection (FBP) method, which directly calculates the image in a single reconstruction step. In recent research works, scientists have shown that extremely fast computations and massive parallelism is possible for iterative reconstruction, which makes iterative reconstruction practical for commercialization. == Basic concepts == The reconstruction of an image from the acquired data is an inverse problem. Often, it is not possible to exactly solve the inverse problem directly. In this case, a direct algorithm has to approximate the solution, which might cause visible reconstruction artifacts in the image. Iterative algorithms approach the correct solution using multiple iteration steps, which allows to obtain a better reconstruction at the cost of a higher computation time. There are a large variety of algorithms, but each starts with an assumed image, computes projections from the image, compares the original projection data and updates the image based upon the difference between the calculated and the actual projections. === Algebraic reconstruction === The Algebraic Reconstruction Technique (ART) was the first iterative reconstruction technique used for computed tomography by Hounsfield. === Iterative Sparse Asymptotic Minimum Variance === The iterative sparse asymptotic minimum variance algorithm is an iterative, parameter-free superresolution tomographic reconstruction method inspired by compressed sensing, with applications in synthetic-aperture radar, computed tomography scan, and magnetic resonance imaging (MRI). === Statistical reconstruction === There are typically five components to statistical iterative image reconstruction algorithms, e.g. An object model that expresses the unknown continuous-space function f ( r ) {\displaystyle f(r)} that is to be reconstructed in terms of a finite series with unknown coefficients that must be estimated from the data. A system model that relates the unknown object to the "ideal" measurements that would be recorded in the absence of measurement noise. Often this is a linear model of the form A x + ϵ {\displaystyle \mathbf {A} x+\epsilon } , where ϵ {\displaystyle \epsilon } represents the noise. A statistical model that describes how the noisy measurements vary around their ideal values. Often Gaussian noise or Poisson statistics are assumed. Because Poisson statistics are closer to reality, it is more widely used. A cost function that is to be minimized to estimate the image coefficient vector. Often this cost function includes some form of regularization. Sometimes the regularization is based on Markov random fields. An algorithm, usually iterative, for minimizing the cost function, including some initial estimate of the image and some stopping criterion for terminating the iterations. === Learned Iterative Reconstruction === In learned iterative reconstruction, the updating algorithm is learned from training data using techniques from machine learning such as convolutional neural networks, while still incorporating the image formation model. This typically gives faster and higher quality reconstructions and has been applied to CT and MRI reconstruction. == Advantages == The advantages of the iterative approach include improved insensitivity to noise and capability of reconstructing an optimal image in the case of incomplete data. The method has been applied in emission tomography modalities like SPECT and PET, where there is significant attenuation along ray paths and noise statistics are relatively poor. Statistical, likelihood-based approaches: Statistical, likelihood-based iterative expectation-maximization algorithms are now the preferred method of reconstruction. Such algorithms compute estimates of the likely distribution of annihilation events that led to the measured data, based on statistical principle, often providing better noise profiles and resistance to the streak artifacts common with FBP. Since the density of radioactive tracer is a function in a function space, therefore of extremely high-dimensions, methods which regularize the maximum-likelihood solution turning it towards penalized or maximum a-posteriori methods can have significant advantages for low counts. Examples such as Ulf Grenander's Sieve estimator or Bayes penalty methods, or via I.J. Good's roughness method may yield superior performance to expectation-maximization-based methods which involve a Poisson likelihood function only. As another example, it is considered superior when one does not have a large set of projections available, when the projections are not distributed uniformly in angle, or when the projections are sparse or missing at certain orientations. These scenarios may occur in intraoperative CT, in cardiac CT, or when metal artifacts require the exclusion of some portions of the projection data. In Magnetic Resonance Imaging it can be used to reconstruct images from data acquired with multiple receive coils and with sampling patterns different from the conventional Cartesian grid and allows the use of improved regularization techniques (e.g. total variation) or an extended modeling of physical processes to improve the reconstruction. For example, with iterative algorithms it is possible to reconstruct images from data acquired in a very short time as required for real-time MRI (rt-MRI). In Cryo Electron Tomography, where the limited number of projections are acquired due to the hardware limitations and to avoid the biological specimen damage, it can be used along with compressive sensing techniques or regularization functions (e.g. Huber function) to improve the reconstruction for better interpretation. Here is an example that illustrates the benefits of iterative image reconstruction for cardiac MRI.
Adobe Presenter Video Express
Adobe Presenter Video Express is screencasting and video editing software developed by Adobe Systems. == Description == Adobe Presenter Video Express is primarily used as a software by video creators, to record and mix webcam and screen video feeds. It allows users to simultaneously record video from their webcam and the screen, and easily mix the 2 tracks with a simple user interface. Users can change the background in their recorded video without needing equipment like a green screen. This is unlike other video tools which rely on chroma keying technology, and only work with green or blue screens. They can also add annotations and quizzes to their content and publish the video to MP4 or HTML5 formats. == List of notable features == === Record and mix, screen and webcam === Support for simultaneous recording of screen and webcam video feeds, with a simple editing interface to mix the two video streams. This lets the author rapidly create screencasts, software demos, etc. === Make my background awesome === This feature allows authors to change the background of their webcam recording without needing a green screen, provided they use a solid-colored backdrop which contrasts well against them. Authors can select images, videos or even the screen recording as their background. === In-video quizzing === Authors can insert quizzes within their video content. On success/failure attempts, the author can decide what message to display, and can also configure the video to jump to a certain point and play. Quizzes are published as part of the interactive HTML 5 player, which cannot be hosted on YouTube and Vimeo. === LMS Reporting === Authors can publish to any SCORM compliant LMS (Learning Management System) for quiz reporting, or to Adobe Captivate Prime. === In-app assets and branding === Adobe Presenter Video Express ships with a large number of branding videos, backgrounds and video filters to help authors create studio quality videos. === MP4 and HTML5 Output === The tool publishes a single MP4 video file containing all the video content, within an HTML 5 wrapper that contains the interactive player. The interactive HTML 5 player can be hosted on any website. == Common uses == === Screencasting === Screencasting is the process of recording one's computer screen as a video, usually with an audio voice over, to create a software demonstration, tutorial, presentation, etc. Adobe Presenter Video Express supports simultaneous recording of full screen video and microphone audio for creating screencasts. === Product marketing and demos === The ability to record the webcam video in addition to everything that is visible on the screen in Adobe Presenter Video Express, allows the author to add their personality to their screencasts. Features like video mixing and 'make my background awesome' further enhance the presentation, allowing effortless creation of marketing and demo videos. === Education === Adobe Presenter Video Express supports in-video quizzes and LMS reporting, along with screencasting and webcam recording. These features make it a powerful tool for creating educational content. == Differences from Adobe Presenter and Adobe Captivate == Adobe Presenter is a Microsoft PowerPoint plug-in for converting PowerPoint slides into interactive eLearning content, available only on Windows. Starting with Adobe Presenter 8, the video creation tool Adobe Presenter Video Express was bundled with every purchase of Adobe Presenter. From September 2015, Adobe Presenter Video Express 11 was also made available as a stand-alone product on Windows and Mac. A subscription license for Adobe Presenter Video Express, valid on Windows and Mac, is available for $9.99/month. Adobe Presenter Video Express continues to be bundled with purchases of Adobe Presenter on Windows as well. Adobe Captivate is an authoring tool for creating numerous forms of interactive eLearning content. Unlike Adobe Presenter, it uses a proprietary editing interface instead of Microsoft PowerPoint. While it is possible to create screen captures with Adobe Captivate, you cannot record the webcam feed. Adobe Captivate does not bundle Adobe Presenter or Adobe Presenter Video Express.
BigDog
BigDog is a dynamically stable quadruped military robot platform that was created in 2005 by Boston Dynamics with the Harvard University Concord Field Station. It was funded by the U.S. Defense Advanced Research Projects Agency (DARPA), but the project was shelved after the BigDog's gas engine was deemed too loud for combat. == History == BigDog was funded by the Defense Advanced Research Projects Agency (DARPA) in the hopes that it would be able to serve as a mechanic pack mule to accompany soldiers in terrain too rough for conventional vehicles. Instead of wheels or treads, BigDog uses four legs for movement, allowing it to move across surfaces that would be difficult for wheels. The legs contain a variety of sensors, including joint position and ground contact. BigDog also features a laser gyroscope and a stereo vision system. BigDog is 3 feet (0.91 m) long, stands 2.5 feet (0.76 m) tall, and weighs 240 pounds (110 kg), making it about the size of a small mule. It is capable of traversing difficult terrain, running at four miles per hour (6.4 km/h), carrying 340 pounds (150 kg), and climbing a 35 degree incline. Locomotion is controlled by an onboard computer that receives input from the robot's various sensors. Navigation and balance are also managed by the control system. BigDog's walking pattern is controlled through four legs, each equipped with four low-friction hydraulic cylinder actuators that power the joints. BigDog's locomotion behaviors can vary greatly. It can stand up, sit down, walk with a crawling gait that lifts one leg at a time, walk with a trotting gait lifting diagonal legs, or trot with a running gait. The travel speed of BigDog varies from a 0.62 mph (1 km/h) crawl to a 3.3 mph (5.3 km/h) trot. The BigDog project was headed by Dr. Martin Buehler, who received the Joseph Engelberger Award from the Robotics Industries Association in 2012 for the work. Dr. Buehler while previously a professor at McGill University, headed the robotics lab there, developing four-legged walking and running robots. Built onto the actuators are sensors for joint position and force, and movement is ultimately controlled through an onboard computer which manages the sensors. Approximately 50 sensors are located on BigDog. These measure the attitude and acceleration of the body, motion, and force of joint actuators as well as engine speed, temperature and hydraulic pressure inside the robot's internal engine. Low-level control, such as position and force of the joints, and high-level control such as velocity and altitude during locomotion, are both controlled through the onboard computer. BigDog was featured in episodes of Web Junk 20 and Hungry Beast, and in articles in New Scientist, Popular Science, Popular Mechanics, and The Wall Street Journal. In September 2011 Boston Dynamics released video footage of a new generation of BigDog known as AlphaDog. The footage shows AlphaDog's ability to walk on rough terrain and recover its balance when kicked from the side. The refined equivalent has been designed by Boston Dynamics to exceed the BigDog in terms of capabilities and use to dismounted soldiers. In February 2012, with further DARPA support, the militarized Legged Squad Support System (LS3) variant of BigDog demonstrated its capabilities during a hike over a rough terrain. Starting in the summer of 2012, DARPA planned to complete the overall development of the system and refine its key capabilities in 18 months, ensuring its worth to dismounted warfighters before it is rolled out to squads operating in-theatre. BigDog must be able to demonstrate its ability to complete a 20-mile (32 km) trail in 24 hours, without refuelling, while carrying a 325-pound (150 kg) load. A refinement of its vision sensors will also be conducted. At the end of February 2013, Boston Dynamics released video footage of a modified BigDog with an arm. The arm could pick up objects and throw them. The robot is relying on its legs and torso to help power the motions of the arm. It is believed that it can lift weights around 55 pounds (25 kg). This work was funded by the United States Army Research Laboratory and paved the way for integrating manipulators with quadrupeds as found on Spot, the spiritual successor of BigDog. === Discontinuation === At the end of December 2013, the BigDog project was discontinued. Despite hopes that it would one day work like a pack mule for US soldiers in the field, the gasoline-powered engine was deemed too noisy for use in combat, and it could be heard from hundreds of meters away. A similar project for an all-electric robot named Spot in 2016 was much quieter, but could only carry 45 pounds (20 kg). Both projects are no longer in progress, but the Spot was only released in 2020. == Hardware == BigDog is powered by a small two-stroke, one-cylinder, 15-brake-horsepower (11 kW) engine operating at 9,000 RPM. The engine drives a hydraulic pump, which in turn drives the hydraulic leg actuators. Each leg has four actuators (two for the hip joint, and two each for the knee and ankle joints), for a total of 16. Each actuator unit consists of a hydraulic cylinder, servo valve, position sensor, and force sensor. Onboard computing power is a ruggedized PC/104 board stack with two computers, one running a Pentium M processor running QNX (used for sensor data processing) and another running a Core Duo processor (used for visual data processing). == Gallery ==
Comparison of vector graphics editors
A number of vector graphics editors exist for various platforms. Potential users of these editors will make comparisons based on factors such as the availability for the user's platform, the software license, the feature set, the merits of the user interface (UI) and the focus of the program. Some programs are more suitable for artistic work while others are better for technical drawings. Another important factor is the application's support of various vector and bitmap image formats for import and export. The tables in this article compare general and technical information for a number of vector graphics editors. See the article on each editor for further information. This article is neither all-inclusive nor necessarily up-to-date. == Some editors in detail == Adobe Fireworks (formerly Macromedia Fireworks) is a vector editor with bitmap editing capabilities with its main purpose being the creation of graphics for Web and screen. Fireworks supports RGB color scheme and has no CMYK support. This means it is mostly used for screen design. The native Fireworks file format is editable PNG (FWPNG or PNG). Adobe Fireworks has a competitive price, but its features can seem limited in comparison with other products. It is easier to learn than other products and can produce complex vector artwork. The Fireworks editable PNG file format is not supported by other Adobe products. Fireworks can manage the PSD and AI file formats which enables it to be integrated with other Adobe apps. Fireworks can also open FWPNG/PNG, PSD, AI, EPS, JPG, GIF, BMP, TIFF file formats, and save/export to FWPNG/PNG, PSD, AI (v.8), FXG (v.2.0), JPG, GIF, PDF, SWF and some others. Some support for exporting to SVG is available via a free Export extension. On May 6, 2013, Adobe announced that Fireworks would be phased out. Adobe Flash (formerly a Macromedia product) has straightforward vector editing tools that make it easier for designers and illustrators to use. The most important of these tools are vector lines and fills with bitmap-like selectable areas, simple modification of curves via the "selection" or the control points/handles through "direct selection" tools. Flash uses Actionscript for OOP, and has full XML functionality through E4X support. Adobe FreeHand (formerly Macromedia Freehand and Aldus Freehand) is mainly used by professional graphic designers. The functionality of FreeHand includes the flexibility of the application in the wide design environment, catering to the output needs of both traditional image reproduction methods and to contemporary print and digital media with its page-layout capabilities and text attribute controls. Specific functions of FreeHand include a superior image-tracing operation for vector editing, page layout features within multiple-page documents, and embedding custom print-settings (such as variable halftone-screen specifications within a single graphic, etc.) to each document independent of auxiliary printer-drivers. User-operation is considered to be more suited for designers with an artistic background compared to designers with a technical background. When being marketed, FreeHand lacked the promotional backing, development and PR support in comparison to other similar products. FreeHand was transferred to the classic print group after Macromedia was purchased by Adobe in 2005. On May 16, 2007, Adobe announced that no further updates to Freehand would be developed but continues to sell FreeHand MX as a Macromedia product. FreeHand continues to run on Mac OS X Snow Leopard (using an Adobe fix) and on Windows 7. For macOS, Affinity Designer is able to open version 10 & MX Freehand files. Adobe Illustrator is a commonly used editor because of Adobe's market dominance, but is more expensive than other similar products. It is primarily developed consistently in line with other Adobe products and is best integrated with Adobe's Creative Suite packages. The ai file format is proprietary, but some vector editors can open and save in that format. Illustrator imports over two dozen formats, including PSD, PDF and SVG, and exports AI, PDF, SVG, SVGZ, GIF, JPG, PNG, WBMP, and SWF. However, the user must be aware of unchecking the "Preserve Illustrator Editing Capabilities" option if generating interoperable SVG files is desired. Affinity Designer by Serif Europe (the successor to their previous product, DrawPlus) is non-subscription-based software that is often described as an alternative to Adobe Illustrator. The application can open Portable Document Format (PDF), Adobe Photoshop, and Adobe Illustrator files, as well as export to those formats and to the Scalable Vector Graphics (SVG) and Encapsulated PostScript (EPS) formats. It also supports import from some Adobe Freehand files (specifically versions 10 & MX). Apache OpenOffice Draw is the vector graphics editor of the Apache OpenOffice open source office suite. It supports many import and export file formats and is available for multiple desktop operating systems. Boxy SVG is a chromium-based vector graphics editor for creating illustrations, as well as logos, icons, and other elements of graphic design. It is primarily focused on editing drawings in the SVG file format. The program is available as both a web app and a desktop application for Windows, macOS, ChromeOS, and Linux-based operating systems. Collabora Online Draw is the vector graphics editor of the Collabora Online open source office suite. It supports many import and export file formats and is accessible via any modern web browser, it also supports desktop editing features, Collabora Office is available for desktop and mobile operating systems, it is the enterprise ready version of LibreOffice. ConceptDraw PRO is a business diagramming tool and vector graphics editor available for both Windows and macOS. It supports multi-page documents, and includes an integrated presentation mode. ConceptDraw PRO supports imports and exports several formats, including Microsoft Visio and Microsoft PowerPoint. Corel Designer (originally Micrografx Designer) is one of the earliest vector-based graphics editors for the Microsoft Windows platform. The product is mainly used for the creation of engineering drawings and is shipped with extensive libraries for the needs of engineers. It is also flexible enough for most vector graphics design applications. CorelDRAW is an editor used in the graphic design, sign making and fashion design industries. CorelDRAW is capable of limited interoperation by reading file formats from Adobe Illustrator. CorelDRAW has over 50 import and export filters, on-screen and dialog box editing and the ability to create multi-page documents. It can also generate TrueType and Type 1 fonts, although refined typographic control is better suited to a more specific application. Some other features of CorelDRAW include the creation and execution of VBA macros, viewing of colour separations in print preview mode and integrated professional imposing options. Dia is a free and open-source diagramming and vector graphics editor available for Windows, Linux and other Unix-based computer operating systems. Dia has a modular design and several shape packages for flowcharting, network diagrams and circuit diagrams. Its design was inspired by Microsoft Visio, although it uses a Single Document Interface similar to other GNOME software (such as GIMP). DrawPlus, first built for the Windows platform in 1993, has matured into a full featured vector graphics editor for home and professional users. Also available as a feature-limited free 'starter edition': DrawPlus SE. DrawPlus developers, Serif Europe, have now ceased its development in order to focus on its successor, Affinity Designer. Edraw Max is a cross-platform diagram software and vector graphics editor available for Windows, Mac and Linux. It supports kinds of diagram types. It supports imports and exports SVG, PDF, HTML, Multiple page TIFF, Microsoft Visio and Microsoft PowerPoint. Embroidermodder is a free machine embroidery software tool that supports a variety of formats and allows the user to add custom modifications to their embroidery designs. Fatpaint is a free, light-weight, browser-based graphic design application with built-in vector drawing tools. It can be accessed through any browser with Flash 9 installed. Its integration with Zazzle makes it particularly suitable for people who want to create graphics for custom printed products such as T-shirts, mugs, iPhone cases, flyers and other promotional products. Figma is a collaborative web-based online vector graphics editor, used primarily for UX design and prototyping. GIMP, which works mainly with raster images, offers a limited set of features to create and record SVG files. It can also load and handle SVG files created with other software like Inkscape. Inkscape is a free and open-source vector editor with the primary native format being SVG. Inkscape is available for Linux, Windows, Mac OS X, and
Fling (social network)
Fling was a social media app available for IOS and Android. It was founded in 2014 by Marco Nardone and was taken offline in August 2016. == Overview == In 2012, Marco Nardone founded the startup Unii and launched Unii.com, a social network intended for students in the UK. While working on this service, Nardone had the idea for a messaging service where pictures could be sent to strangers in January 2014. The app Fling was then developed and released between March and July 2014. After a month, it already had 375,000 downloads and 180,000 active users on iOS. Users were able to take pictures inside the app and send them to 50 random people all over the world. The recipient could then choose to answer via chat or reply by sending a picture themselves. The app was used by many users as a medium to exchange sexually explicit pictures and for sexting with strangers. This led to the app being removed from the App Store in June 2015. In the 19 days that followed, flings developers rewrote the App almost completely from scratch, working around the clock. The feature to message random strangers was removed, and the app was readmitted into the App Store as a messenger App resembling Snapchat. But the redesigned Application did not have the success of its predecessor. The funding ran out and the parent company Unii went bankrupt. The company was not able to pay their content moderation team anymore, leading to a new surge of pornographic content on the App. Shortly after that, the Social Network was taken offline in August 2016. It has been inactive since. During the 2 years Fling was online, $21 million was raised from investors while generating no revenue at all. Of this $21 million (£16.5m), £5 million came from Nardone's father. == Allegations against CEO == Former employees made multiple allegations against Marco Nardone, the Founder and CEO of Unii and Fling. According to these claims, he behaved erratic and abusive, throwing "things across the office". He hired his girlfriend as the head of human resources to handle issues between him and his staff. Employees who left the company often had "some part of their pay held back". According to the reports, he also spent the money raised from investors irresponsibly, having no clear concept of a budget. Some of that money was used on expensive restaurants in London, a luxurious office for CEO Nardone and advertisements for Fling on Twitter and Facebook. Nardone also spent time partying in Ibiza with two employees, while the developer team in London frantically tried to get Fling back online after it being removed from the App Store. In December 2017 he pleaded guilty to assaulting his girlfriend at a domestic violence court.