Clue is a menstrual health app developed by the Berlin-based technology company BioWink GmbH. The app has over 15 million users from 180 countries. The startup has raised over $17 million from backers that include Union Square Ventures and Mosaic Ventures. == History == Clue was co-founded by Ida Tin, Hans Raffauf, Mike LaVigne and Moritz von Buttlar in 2012. BioWink GmbH launched the app in 2013. Ida Tin's stated goal was to take female reproductive health “out of taboo land” and to start “a reproductive health revolution.” Tin previously led motorbike tours around the world and wrote a book about her experience. By July 2017, the Clue app had more than 8 million active users on both Android and iOS. Users were representative of more than 180 countries. In 2015, BioWink GmbH closed a $7 million Series A funding round led by Union Square Ventures and Mosaic Ventures, bringing the company's total funding to $10 million. The company was listed as one of Europe's Hottest Startups in 2015 by Wired UK, with Clue being named one of the best apps in 2015 by both Apple and Google. In March 2018, the company launched an editorial site to serve as a resource for accessible and scientific menstrual health information. == Mobile app == The Clue mobile application calculates and predicts a user's period, fertile window, and premenstrual syndrome. It also informs users the most or least likely time for becoming pregnant and allows them to track more than 30 health categories, including sex, sleep, pain, exercise, hair, skin, digestion, emotions and energy. The app can also explain how pill dosages impact fertility and includes an alarm system to allow for reminders for taking pills. In 2015, the company closed a Series A funding round and announced plans to use the proceeds to expand features of the mobile app and hire more staff. Clue also partnered with universities such as Stanford University, Columbia University, University of Washington, and University of Oxford to advance female health research. Clue integrated with Apple Inc.'s HealthKit for iOS 9 in September 2015, allowing data such as body temperature, cervical mucus quality, menstruation, ovulation test results, sexual activity, and spotting directly to the app. In 2016, Clue was available in 15 languages on both iOS and Android. That same year, Clue introduced a cycle-sharing feature and in 2017 a pill-tracking option. In February 2018, Clue made its app available on the Fitbit Ionic smartwatch. In 2026, Clue partnered with UK-based digital healthcare platform Evaro, an NHS-licensed provider, to offer embedded prescription services within the app.
Backend as a service
Backend as a service (BaaS), sometimes also referred to as mobile backend as a service (MBaaS), is a service for providing web app and mobile app developers with a way to easily build a backend to their frontend applications. Features available include user management, push notifications, and integration with social networking services. These services are provided via the use of custom software development kits (SDKs) and application programming interfaces (APIs). BaaS is a relatively recent development in cloud computing, with most BaaS startups dating from 2011 or later. Some of the most popular service providers are AWS Amplify and Firebase. == Purpose == Web and mobile apps require a similar set of features on the backend, including notification service, integration with social networks, and cloud storage. Each of these services has its own API that must be individually incorporated into an app, a process that can be time-consuming and complicated for app developers. BaaS providers form a bridge between the frontend of an application and various cloud-based backends via a unified API and SDK. Providing a consistent way to manage backend data means that developers do not need to redevelop their own backend for each of the services that their apps need to access, potentially saving both time and money. Although similar to other cloud-computing business models, such as serverless computing, software as a service (SaaS), infrastructure as a service (IaaS), and platform as a service (PaaS), BaaS is distinct from these other services in that it specifically addresses the cloud-computing needs of web and mobile app developers by providing a unified means of connecting their apps to cloud services. == Features == BaaS providers offer different set of features and backend tools. Some of the most common features include: Database management. Most BaaS solutions provide SQL and/or NoSQL database management services for applications. Developers can store their app data without deploying and managing databases themselves. BaaS usually provides client SDKs, REST and GraphQL APIs for the frontend to interact with databases. File storage. BaaS providers often offer storage solutions for media files, user uploads, and other binary data. Applications can upload, download, and delete files through provided SDKs and APIs. Authentication and authorization. Some BaaS offer authentication and authorization services that allow developers to easily manage app users. This includes user sign-up, login, password reset, social media login integration through OAuth, user group and permission management etc. Notification service. Some BaaS providers such as Firebase and AWS Amplify have notification services that can send custom emails to users and push native notifications on mobile platforms. This is especially useful for applications that need to send messages, alerts, and reminders. Cloud functions. Some BaaS allow developers to deploy and run serverless functions. The functions are usually stateless and can be triggered by various ways including HTTP requests, SDK invocation, background server events, and cloud scheduled executions. Different providers offer runtime support for different languages, some of the popular languages are JavaScript/TypeScript (Node.js, Deno), Python, Java/Kotlin. Cloud functions extend the potential and flexibility of BaaS by allowing developers to write custom functionalities for their apps, working in a way similar to a traditional REST API backend framework. Usage analytics. Analytics data about application usage is often included in BaaS. This allows developers to monitor user behaviors and make decisions correspondingly in marketing strategies and performance optimizations. UI design. Some BaaS providers, such as AWS Amplify and Backendless, offer user interface designing tools that help developers design the frontend UI of web and mobile apps. While this may be useful for small teams and individual developers, UI design assistance may not be conventional in BaaS as it goes beyond the scope of backend infrastructure. Real-Time. Real-time features in a BaaS platform ensure that data updates and synchronizations occur instantly across all clients, making changes immediately visible to users. This is crucial for applications like live chat and collaborative tools, using technologies like WebSockets to maintain continuous server-client connections. == Service providers == BaaS providers have a broad focus, providing SDKs and APIs that work for app development on multiple platforms with different technology stacks, such as JavaScript (for Web apps), Flutter, Java/Kotlin (for Android apps), Swift/Objective-C (for iOS/MacOS/WatchOS/TvOS apps), .NET (for Windows) and others. BaaS providers also come in different types, suiting developers of different needs. === Cloud-based BaaS === Most BaaS providers host backend platforms on their cloud servers. They also manage the infrastructure, security, and scalability of the platforms. Developers can access the backend services via a web interface or the provided APIs. Some examples of cloud-based BaaS include Firebase (hosted on Google Cloud Platform), AWS Amplify (hosted on Amazon Web Services), and Microsoft Azure Mobile Apps (hosted on Microsoft Azure). === Self-hosted BaaS === Self-hosted BaaS allow developers to host backend on their own servers, providing more flexibility and potential to customization compared to cloud-based BaaS, which often is more difficult to migrate from. However, developers are also in charge of managing the infrastructure, security, and scalability of their servers. === Mobile BaaS === Mobile backend as a service (MBaaS) is a type of BaaS specifically for applications deployed in mobile systems. While some references use MBaaS interchangeably for BaaS, BaaS can have a wider variety of support such as for web apps and desktop apps. == Business model == BaaS providers generate revenue from their services in various ways, often using a freemium model. Under this model, a client receives a certain number of free active users or API calls per month, and pays a fee for each user or call over this limit. Alternatively, clients can pay a set fee for a package which allows for a greater number of calls or active users per month. There are also flat fee plans that make the pricing more predictable. Some of the providers offer the unlimited API calls inside their free plan offerings. Another business model that has been used by a lot of BaaS providers is PAYG (pay as you go), which has a flexible cost based on developers' usage of database, storage, bandwidth, function calls, user numbers etc.
Model-based clustering
In statistics, cluster analysis is the algorithmic grouping of objects into homogeneous groups based on numerical measurements. Model-based clustering based on a statistical model for the data, usually a mixture model. This has several advantages, including a principled statistical basis for clustering, and ways to choose the number of clusters, to choose the best clustering model, to assess the uncertainty of the clustering, and to identify outliers that do not belong to any group. == Model-based clustering == Suppose that for each of n {\displaystyle n} observations we have data on d {\displaystyle d} variables, denoted by y i = ( y i , 1 , … , y i , d ) {\displaystyle y_{i}=(y_{i,1},\ldots ,y_{i,d})} for observation i {\displaystyle i} . Then model-based clustering expresses the probability density function of y i {\displaystyle y_{i}} as a finite mixture, or weighted average of G {\displaystyle G} component probability density functions: p ( y i ) = ∑ g = 1 G τ g f g ( y i ∣ θ g ) , {\displaystyle p(y_{i})=\sum _{g=1}^{G}\tau _{g}f_{g}(y_{i}\mid \theta _{g}),} where f g {\displaystyle f_{g}} is a probability density function with parameter θ g {\displaystyle \theta _{g}} , τ g {\displaystyle \tau _{g}} is the corresponding mixture probability where ∑ g = 1 G τ g = 1 {\displaystyle \sum _{g=1}^{G}\tau _{g}=1} . Then in its simplest form, model-based clustering views each component of the mixture model as a cluster, estimates the model parameters, and assigns each observation to cluster corresponding to its most likely mixture component. === Gaussian mixture model === The most common model for continuous data is that f g {\displaystyle f_{g}} is a multivariate normal distribution with mean vector μ g {\displaystyle \mu _{g}} and covariance matrix Σ g {\displaystyle \Sigma _{g}} , so that θ g = ( μ g , Σ g ) {\displaystyle \theta _{g}=(\mu _{g},\Sigma _{g})} . This defines a Gaussian mixture model. The parameters of the model, τ g {\displaystyle \tau _{g}} and θ g {\displaystyle \theta _{g}} for g = 1 , … , G {\displaystyle g=1,\ldots ,G} , are typically estimated by maximum likelihood estimation using the expectation-maximization algorithm (EM); see also EM algorithm and GMM model. Bayesian inference is also often used for inference about finite mixture models. The Bayesian approach also allows for the case where the number of components, G {\displaystyle G} , is infinite, using a Dirichlet process prior, yielding a Dirichlet process mixture model for clustering. === Choosing the number of clusters === An advantage of model-based clustering is that it provides statistically principled ways to choose the number of clusters. Each different choice of the number of groups G {\displaystyle G} corresponds to a different mixture model. Then standard statistical model selection criteria such as the Bayesian information criterion (BIC) can be used to choose G {\displaystyle G} . The integrated completed likelihood (ICL) is a different criterion designed to choose the number of clusters rather than the number of mixture components in the model; these will often be different if highly non-Gaussian clusters are present. === Parsimonious Gaussian mixture model === For data with high dimension, d {\displaystyle d} , using a full covariance matrix for each mixture component requires estimation of many parameters, which can result in a loss of precision, generalizabity and interpretability. Thus it is common to use more parsimonious component covariance matrices exploiting their geometric interpretation. Gaussian clusters are ellipsoidal, with their volume, shape and orientation determined by the covariance matrix. Consider the eigendecomposition of a matrix Σ g = λ g D g A g D g T , {\displaystyle \Sigma _{g}=\lambda _{g}D_{g}A_{g}D_{g}^{T},} where D g {\displaystyle D_{g}} is the matrix of eigenvectors of Σ g {\displaystyle \Sigma _{g}} , A g = diag { A 1 , g , … , A d , g } {\displaystyle A_{g}={\mbox{diag}}\{A_{1,g},\ldots ,A_{d,g}\}} is a diagonal matrix whose elements are proportional to the eigenvalues of Σ g {\displaystyle \Sigma _{g}} in descending order, and λ g {\displaystyle \lambda _{g}} is the associated constant of proportionality. Then λ g {\displaystyle \lambda _{g}} controls the volume of the ellipsoid, A g {\displaystyle A_{g}} its shape, and D g {\displaystyle D_{g}} its orientation. Each of the volume, shape and orientation of the clusters can be constrained to be equal (E) or allowed to vary (V); the orientation can also be spherical, with identical eigenvalues (I). This yields 14 possible clustering models, shown in this table: It can be seen that many of these models are more parsimonious, with far fewer parameters than the unconstrained model that has 90 parameters when G = 4 {\displaystyle G=4} and d = 9 {\displaystyle d=9} . Several of these models correspond to well-known heuristic clustering methods. For example, k-means clustering is equivalent to estimation of the EII clustering model using the classification EM algorithm. The Bayesian information criterion (BIC) can be used to choose the best clustering model as well as the number of clusters. It can also be used as the basis for a method to choose the variables in the clustering model, eliminating variables that are not useful for clustering. Different Gaussian model-based clustering methods have been developed with an eye to handling high-dimensional data. These include the pgmm method, which is based on the mixture of factor analyzers model, and the HDclassif method, based on the idea of subspace clustering. The mixture-of-experts framework extends model-based clustering to include covariates. == Example == We illustrate the method with a dateset consisting of three measurements (glucose, insulin, sspg) on 145 subjects for the purpose of diagnosing diabetes and the type of diabetes present. The subjects were clinically classified into three groups: normal, chemical diabetes and overt diabetes, but we use this information only for evaluating clustering methods, not for classifying subjects. The BIC plot shows the BIC values for each combination of the number of clusters, G {\displaystyle G} , and the clustering model from the Table. Each curve corresponds to a different clustering model. The BIC favors 3 groups, which corresponds to the clinical assessment. It also favors the unconstrained covariance model, VVV. This fits the data well, because the normal patients have low values of both sspg and insulin, while the distributions of the chemical and overt diabetes groups are elongated, but in different directions. Thus the volumes, shapes and orientations of the three groups are clearly different, and so the unconstrained model is appropriate, as selected by the model-based clustering method. The classification plot shows the classification of the subjects by model-based clustering. The classification was quite accurate, with a 12% error rate as defined by the clinical classification. Other well-known clustering methods performed worse with higher error rates, such as single-linkage clustering with 46%, average link clustering with 30%, complete-linkage clustering also with 30%, and k-means clustering with 28%. == Outliers in clustering == An outlier in clustering is a data point that does not belong to any of the clusters. One way of modeling outliers in model-based clustering is to include an additional mixture component that is very dispersed, with for example a uniform distribution. Another approach is to replace the multivariate normal densities by t {\displaystyle t} -distributions, with the idea that the long tails of the t {\displaystyle t} -distribution would ensure robustness to outliers. However, this is not breakdown-robust. A third approach is the "tclust" or data trimming approach which excludes observations identified as outliers when estimating the model parameters. == Non-Gaussian clusters and merging == Sometimes one or more clusters deviate strongly from the Gaussian assumption. If a Gaussian mixture is fitted to such data, a strongly non-Gaussian cluster will often be represented by several mixture components rather than a single one. In that case, cluster merging can be used to find a better clustering. A different approach is to use mixtures of complex component densities to represent non-Gaussian clusters. == Non-continuous data == === Categorical data === Clustering multivariate categorical data is most often done using the latent class model. This assumes that the data arise from a finite mixture model, where within each cluster the variables are independent. === Mixed data === These arise when variables are of different types, such as continuous, categorical or ordinal data. A latent class model for mixed data assumes local independence between the variable. The location model relaxes the local independence assumption. The clustMD approach assumes that the observed variables are manifestations of underlying continuous Gaussian latent
DesktopTwo
Desktoptwo was a free Webtop (whose URL was desktoptwo.com and which is now a parked domain) developed by Sapotek (whose URL was sapotek.com, which also is now a parked domain). It's also been called a WebOS although Sapotek stated on its website that the term is premature and presumptuous. It mimics the look, feel and functionality of the desktop environment of an operating system. The software only reached beta stage. It had a Spanish version called Computadora.de. Desktoptwo was web-based and required Adobe Flash Player to operate. The web applications' found on Desktoptwo were built on PHP in the back end. Features included drag-and-drop functionality. Sapotek had liberated all the web applications found on Desktoptwo through Sapodesk on an AGPL license. Desktoptwo belonged to a category of services that intended to turn the Web into a full-fledged platform by using web services as a foundation along with presentation technologies that replicated the experience of desktop applications for users. In a "Cloud OS" the functionality of a server was granularized and abstracted as Web services that Web developers used to create composite applications similar to how desktop software developers use several APIs of the OS to create their applications. Sites like Facebook attempt to create a similar effect by exposing their APIs and allowing developers to create applications upon these. Some of the features found on Desktoptwo were: File sharing, Webmail, Blog creator, Instant messenger, Address book, Calendar, RSS Reader and Office productivity applications. Desktoptwo.com and the Sapotek website no longer operate.
ZeroPC
ZeroPC was a commercial webtop developed by ZeroDesktop, Inc. located in San Mateo, California. ZeroPC has been called a personal cloud OS. It mimicked the look, feel and functionality of the desktop environment of a real operating system. The software was launched in September 2011 through Disrupt SF 2011 event and recently selected to the finalist of SXSW 2012 in Innovative Web Technology category. ZeroPC is web-based and required a Java applet to operate bundled productivity tool Thinkfree. The web applications found on ZeroPC are built on Java in the back end. Features included drag-and-drop functionality, cloud dashboard and personal cloud storage meta services. ZeroPC belonged to a category of services that intended to turn the Web into a full-fledged platform by using Web services as a foundation along with presentation technologies that replicated the experience of desktop applications for users. ZeroPC aggregates content so users can easily access, transfer and share whatever content they want, using a web browser from any device. Its meta-cloud layer supports Dropbox, Box, SugarSync, OneDrive, 4Shared, Google Drive, Evernote, Picasa, Flickr, Instagram, Facebook, Twitter, and Photobucket. ZeroPC Cloud OS platform also provides extensive APIs for iOS and Android App developers. Some of the features found on ZeroPC are: File sharing, Webmail, Cloud Content Navigator, Instant messenger, Sticky Note, Audio/Video Player and Office productivity applications. ZeroPC 2.0 platform ran on AWS for free and paid users. Its platform is licensable to Telco and ISV for commercial purpose. Their clients are SFR, SK Telecom, Hancom and others. As of June 1, 2017, ZeroPC's servers were switched off completely, and ZeroPC is no longer in service since its parent company, NComputing, had launched Virtual Desktop Service in the cloud (AWS) to public. == Browser and Platform Compatibility == The ZeroPC web desktop was compatible with Mac OS X and Microsoft Windows platforms. It is certified to operate on Safari 6.0, Firefox 15.0.1, Google Chrome 22.0.1229.79 m and Internet Explorer 8 and 9. The ZeroPC front end user interface executes entirely within a web browser (see above) and uses HTML, some features of HTML5, JavaScript, AJAX and an optional Java plug-in. == Security == All communication between the ZeroPC front end user interface and the ZeroPC back end servers is encrypted using SSL (HTTPS) protocol. Furthermore, any content stored in the ZeroPC server-side repository is also encrypted using 256-bit Advanced Encryption Standard (AES-256) by Amazon S3 on AWS. ZeroPC users could connect their ZeroPC profile to other storage services such as Dropbox and Box. This connection allows the ZeroPC user to fully manage their content stored in these other storage services. To establish the connection ZeroPC rigorously adhered to the Oauth implementation provided by the target storage service. Upon completion of the Oauth process, ZeroPC stores the relevant access token in the user's profile. This token, along with all other sensitive password related data was encrypted using AES 256-bit key size. == Implementations == As noted above, the ZeroPC platform was hosted on Amazon Web Services infrastructure and is available to the general consumer. A user was allowed to sign up by selecting one of three account plans including a no-cost option. The ZeroPC could also be white-labeled for organizations wishing to provide this functionality to their own users. The white-label options include managed hosting on Amazon Web Services infrastructure and also installation within the organization's IT infrastructure. == User Access Points == The ZeroPC infrastructure provided user access to content and features in several different ways. As described in this article the user can access their information by signing into the ZeroPC web desktop. Additionally, ZeroPC offers native applications designed to run on popular mobile devices including smartphones and tablets. == Leadership == ZeroPC was founded by Chief Executive Officer, Young Song, an entrepreneur who previously founded NComputing, a $60 million venture-backed company. He also co-founded eMachines, Inc., a low-cost computer brand (later acquired by Gateway).
Corel Designer
Corel DESIGNER is a vector-based graphics program. It was originally developed by Micrografx, which was bought by Corel in 2001. The last version developed by Micrografx was 9.0 in 2001. This program was later sold as Corel DESIGNER 9. There are still a number of users who continue working with version 9.0, because newer versions of the product are based on a modified CorelDRAW rather than the original product. Corel DESIGNER is effective for the creation of engineering drawings, but also offers many functions for graphic design. Starting with version X5, Corel DESIGNER Technical Suite includes Corel Designer, CorelDRAW and Corel Photo-Paint. X6 was the last release for Windows XP. == Release history and file formats ==
Viaweb
Viaweb was a web-based application that allowed users to build and host their own online stores with little technical expertise using a web browser. The company was started in July 1995 by Paul Graham, Robert Morris (using the pseudonym "John McArtyem"), and Trevor Blackwell. Graham claims Viaweb was the first application service provider. Viaweb was also unusual for being partially written in the Lisp programming language. The software was originally called Webgen, but another company was using the same name, so the company renamed it to Viaweb, "because it worked via the Web". In 1998, Yahoo! Inc. bought Viaweb for 455,000 shares of Yahoo! capital stock, valued at about $49 million, and renamed it Yahoo! Store. Viaweb's example has been influential in Silicon Valley's entrepreneurial culture, largely due to Graham's widely read essays and his subsequent career as a successful venture capitalist.