In the United States, prescription monitoring programs (PMPs) or prescription drug monitoring programs (PDMPs) are state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, depending on state requirements, other potentially abusable prescription drugs. PMPs are meant to help prevent adverse drug-related events such as opioid overdoses, drug diversion, and substance abuse by decreasing the amount and/or frequency of opioid prescribing, and by identifying those patients who are obtaining prescriptions from multiple providers (i.e., "doctor shopping") or those physicians overprescribing opioids. Most US health care workers support the idea of PMPs, which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments. The database, whose use is required by State law, typically requires prescribers and pharmacies dispensing controlled substances to register with their respective state PMPs and (for pharmacies and providers who dispense from their offices) to report the dispensation of such prescriptions to an electronic online database. The majority of PMPs are authorized to notify law enforcement agencies or licensing boards or physicians when a prescriber, or patients receiving prescriptions, exceed thresholds established by the state or prescription recipient exceeds thresholds established by the State. All states have implemented PDMPs, although evidence for the effectiveness of these programs is mixed. While prescription of opioids has decreased with PMP use, overdose deaths in many states have actually increased, with those states sharing data with neighboring jurisdictions or requiring reporting of more drugs experiencing highest increases in deaths. This may be because those declined opioid prescriptions turn to street drugs, whose potency and contaminants carry greater overdose risk. == History == Prescription drug monitoring programs, or PDMPs, are an example of one initiative proposed to alleviate effects of the opioid crisis. The programs are designed to restrict prescription drug abuse by limiting a patient's ability to obtain similar prescriptions from multiple providers (i.e. “doctor shopping”) and reducing diversion of controlled substances. This is meant to reduce risk of fatal overdose caused by high doses of opioids or interactions between opioids and benzodiazepenes, and to enable better decision making on the part of healthcare providers who may be unaware of a patient's prescription drug use, history or other prescriptions. PDMPs have been implemented in state legislations since 1939 in California, a time before electronic medical records, though implementation rose alongside increased awareness of overprescribing of opioids and overdose. A later New York state program was struck down by the U.S. Supreme Court in Whalen v. Roe. But, by 2019, 49 states, the District of Columbia, and Guam had enacted PDMP legislation. In 2021 Missouri, the last State to not use a PMP, adopted legislation to create one. PMPs are constantly being updated to increase speed of data collection, sharing of data across States, and ease of interpretation. This is being done by integrating PDMP reports with other health information technologies such as health information exchanges (HIE), electronic health record (EHR) systems, and/ or pharmacy dispensing software systems. One program that has been implemented in nine states is called the PDMP Electronic Health Records Integration and Interoperability Expansion, also known as PEHRIIE. Another software, marketed by Bamboo Health and integrated with PMPs in 43 states, uses an algorithm to track factors thought to increase risk of diversion, abuse or overdose, and assigns patients a three digit score based on presumed indicators of risk. While some studies have suggested that PDMP-HIT integration and sharing of interstate data brings benefits such as reduced opioid-related inpatient morbidity, others have found no or negative impact on mortality compared to states without PMP data sharing. Patient and media reports suggest need for testing and evaluation of algorithmic software used to score risk, with some patients reporting denial of prescriptions without c explanation or clarity of data. == Goals == Most health care workers support PMPs which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments, as well as law-enforcement agencies. The collaboration supports the legitimate medical use of controlled substances while limiting their abuse and diversion. Pharmacies dispensing controlled substances and prescribers typically must register with their respective state PMPs and (for pharmacies and providers who dispense controlled substances from their offices) report the dispensation to an electronic online database. Some pharmacy software can submit these reports automatically to multiple states. == Usage == === List of programs by state === === Software systems === NarxCare is a prescription drug monitoring program (PDMP) run by Bamboo Health. Bamboo Health was formerly known as Appriss. It is widely used across the United States by pharmacies including Rite Aid as well as those at Walmart and Sam’s Club. The NarxCare software allows doctors to view data about a patient, combining data from the prescription registries of various U.S. states to make the registries interoperable nationally. It also uses machine learning to generate an "Overdose Risk Score" that potentially includes EMS and criminal justice data; these scores have been criticized by researchers and patient advocates for the lack of transparency in the process as well as the potential for disparate treatment of women and minority groups. Advertised as an "analytics tool and care management platform", the NarxCare software allows doctors to view data about a patient including how many pharmacies they have visited and the combinations of medication they are prescribed. It combines data from the prescription registries of various U.S. states, making the registries interoperable nationally. It additionally uses machine learning to generate various three-digit "risk scores" and an overall "Overdose Risk Score", collectively referred to as Narx Scores, in a process that potentially includes EMS and criminal justice data as well as court records. == Controversy == Many doctors and researchers support the idea of PDMPs as a tool in combatting the opioid epidemic. Opioid prescribing, opioid diversion and supply, opioid misuse, and opioid-related morbidity and mortality are common elements in data entered into PDMPs. Prescription Monitoring Programs are purported to offer economic benefits for the states who implement them by decreasing overall health care costs, lost productivity, and investigation times. However, there are many studies that conclude the impact of PDMPs is unclear. While use of PMPs has been accompanied by decrease in opioid prescribing, few analyses consider corresponding use of street opioids, extramedical use, or diversion, which might provide a more holistic method for evaluation of PMP intent and efficacy. Evidence for PDMP impact on fatal overdoses is decidedly mixed, with multiple studies finding increased overdose rates in some states, decreases in others, or no clear impact. Interestingly, an increase in heroin overdoses after PDMP implementation has been commonly reported, presumably as denial of prescription opioids sends patients in search of street drugs. Narx Scores have been criticized by researchers and patient advocates for the lack of transparency in the generation process as well as the potential for disparate treatment of women and minority groups. Writing in Duke Law Journal, Jennifer Oliva stated that "black-box algorithms" are used to generate the scores.
Deluxe Paint
Deluxe Paint, often referred to as DPaint, is a bitmap graphics editor created by Dan Silva for Electronic Arts and published for the then-new Amiga 1000 in November 1985. A series of updated versions followed, some of which were ported to other platforms. An MS-DOS release with support for the 256 color VGA standard became popular for creating pixel graphics in video games in the 1990s. Author Dan Silva previously worked on the Cut & Paste word processor (1984), also from Electronic Arts. == History == Deluxe Paint began as an in-house art development tool called Prism. As author Dan Silva added features to Prism, it was developed as a showcase product to coincide with the Amiga's debut in 1985. Upon release, it was quickly embraced by the Amiga community and became the de facto graphics (and later animation) editor for the platform. Amiga manufacturer Commodore International later commissioned EA to create version 4.5 AGA to bundle with the new Advanced Graphics Architecture chipset (A1200, A4000) capable Amigas. Version 5 was the last release after Commodore's bankruptcy in 1994. Early versions of Deluxe Paint were available in protected and non copy-protected versions, the latter retailing for a slightly higher price. The copy protection scheme was later dropped. Deluxe Paint was first in a series of products from the Electronic Arts Tools group—then later moved to the ICE (for Interactivity, Creativity, and Education) group—which included such Amiga programs as Deluxe Music Construction Set (preceded by Music Construction Set for the Apple II), Deluxe Video, and the Studio series of paint programs for the Mac. With the development of Deluxe Paint, EA introduced the ILBM and ANIM file format standards for graphics. While widely used on the Amiga, these formats never gained widespread end user acceptance on other platforms, but were heavily used by game development companies. Deluxe Paint was used by LucasArts to make graphics for their adventure games such as The Secret of Monkey Island, and the name of a particular filename used to store the main protagonist Guybrush Threepwood was probably at the origin of his peculiar name. One of the main artist developer of the game, Mark Ferrari, in an interview for The Making of Monkey Island 30th Anniversary Documentary remembers that "there was a pulldown menu in DPaint called brushes, so character sprites were referred to as brushes", and the male protagonist was simply "the guy.brush" until the artist Steve Purcell suggested to take the very name "Guybrush". The author Ron Gilbert remembers that the PC DOS version of the file was named "guybrush.bbm". == Versions == === Amiga === Deluxe Paint I was released in 1985. A major feature was animation by using color cycling. The Amiga natively supports indexed color, where a pixel's color value does not carry any RGB hue information but instead is an index to a color palette (a collection of unique color values). By adjusting the color value in the palette, all pixels with that palette value change simultaneously in the image or animation, creating cyclic movement in the image. In the Christmas demo files on the Deluxe Paint I disk, this kind of animation (which is toggled by pressing the tab key) is used to depict falling snowflakes, a blinking Christmas tree, and a roaring fire in the fireplace. In 1986, Deluxe Paint II was introduced, which added many convenient features such as pattern and gradient fill, which could be selected by right-clicking on a fill tool. An effects menu with e.g. perspective transformation was also added. The screen format could now be changed from a dedicated selection page. Deluxe Paint III appeared in 1989 and added support for Extra Halfbrite. New editing modes allowed one to stencil certain colors to protect them, so it is possible to e.g. paint a landscape from front to back, with the foreground protected by a stencil. A major new feature of Deluxe Paint III was the ability to create cel-like animation, and animbrushes (1MB of RAM is needed for animation). These let the user pick up a section of an animation as an "animbrush", which can then be placed onto the canvas while it animates. Deluxe Paint III was one of the first paint programs to support animbrushes. This is similar to copy and paste, except one can pick up more than one image. Deluxe Paint IV (introduced in 1991), which did not include Silva as the lead programmer, offered significant new features like non-bitplane-indexed Hold-and-Modify support for creating images with up to 4,096 colors. Animation support was improved by adding a light table, i.e. onion skinning, and AnimBrush morphing. The color mixer was now a HAM region at the bottom of the screen (instead of a floating window as before) and allowed mixing adjacent colors similar to a real palette. Deluxe Paint 4.5 AGA appeared the following year, addressing the stability issues and providing support for the new A1200 and A4000 AGA machines and a revamped screen mode interface. It appeared in both standalone and Commodore-bundled versions. The final release, Deluxe Paint V, in 1995, supported true 24-bit RGB images. However, using only the AGA native chipset, the 24-bit RGB color was only held in computer memory, the on-screen image was displayed in HAM8 (18-bit color). === Apple IIGS === DeluxePaint II for the Apple IIGS was developed by Brent Iverson and released in 1987. === MS-DOS === Deluxe Paint II for MS-DOS was released in 1988, It required MS-DOS 2.0 and 640 kB of RAM. It supports CGA, EGA, MCGA, VGA, Hercules and Tandy IBM PC-compatible graphic cards. Deluxe Paint II Enhanced was released in 1989, requiring MS-DOS 2.11 and 640 kB of RAM. It supports resolutions up to 800x600 pixels with 256 colors. Deluxe Paint II Enhanced 2.0, released in 1994, was the most successful MS-DOS version, and was compatible with PC Paintbrush PCX image files. The MS-DOS conversion was done by Brent Iverson with the enhanced features by Steve Shaw. It supports CGA, EGA, MCGA, VGA, Hercules, Tandy, and Amstrad video cards, as well as early Super VGA video cards enabling it to support up to 800 × 600 with 256 (from 262,144) colors and 1024 × 768 with 16 colors. The sister product Deluxe Paint Animation (only for 320×200 pixels and 256 colors) was widely used, especially in video game development. === Atari ST === Deluxe Paint ST was developed by ArtisTech Development, published by Electronic Arts, and was released in 1990. It supports the Atari STE 4096 color palette and animated graphics. Features advertised for the Atari ST version include 3D perspective, design your own fonts, mirror symmetry, multi-color airbrushing & animations, printing up to poster size, split-screen magnification with variable zoom, and working on animations (including multiple animations). == Workflow == "[" and "]" hotkeys step through the indexed palette, turning indexed-pixel-painting into a fast two-handed mouse+keys process, and the right mouse button paints with the background color. For example, transparency is obtained as simply as selecting a background color index (a single right click on the palette GUI to change). colors could be locked from editing by use of a stencil (a list of color indices whose pixels should not be altered in the image data) and simple color-cycling animations could be created using contiguous entries in the palette. This was easy to change the hue and tone of a section of the image by altering the corresponding colors in the palette. (The specific section needed to use a dedicated part of the palette for this technique to work.) Brushes can be cut from the background by using the box, freehand, or polygon selection tools. They can then be used in the same manner as any other brush or pen. This functionality is simpler to use than the "stamp" tool of Photoshop or Alpha Channels as provided in later programs. Brushes can be rotated and scaled, even in 3D. After a brush is selected, it appears attached to the mouse cursor, providing an exact preview of what will be drawn. This allows precise pixel positioning of brushes. Animations stored in IFF ANIM format are delta compressed making animations both smaller and faster to playback. == Reception == Compute! criticized the documentation of the first release of DeluxePaint as inadequate, but stated that "DeluxePaint is a visual arts program of immense scope and flexibility". In later versions the documentation was much improved; for instance DeluxePaint IV came with a 300-page manual. Deluxe Paint was a hit for EA. The main line of the series, particularly installments one to three, has won a total of at least nine awards from independent publications and organizations, including three Amiga-specific awards. Deluxe Paint III also won Commodore International's Enterprise and Vision award in 1990, becoming the first software to win the award, for what the company's judges believed to be best utilizing the Amiga's graphical capabilities. Deluxe Pai
Arabic Speech Corpus
The Arabic Speech Corpus is a Modern Standard Arabic (MSA) speech corpus for speech synthesis. The corpus contains phonetic and orthographic transcriptions of more than 3.7 hours of MSA speech aligned with recorded speech on the phoneme level. The annotations include word stress marks on the individual phonemes. The Arabic Speech Corpus was built as part of a doctoral project by Nawar Halabi at the University of Southampton funded by MicroLinkPC who own an exclusive license to commercialise the corpus, but the corpus is available for strictly non-commercial purposes through the official Arabic Speech Corpus website. It is distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. == Purpose == The corpus was mainly built for speech synthesis purposes, specifically Speech Synthesis, but the corpus has been used for building HMM based voices in Arabic. It was also used to automatically align other speech corpora with their phonetic transcript and could be used as part of a larger corpus for training speech recognition systems. == Contents == The package contains the following: 1813 .wav files containing spoken utterances. 1813 .lab files containing text utterances. 1813 .TextGrid files containing the phoneme labels with time stamps of the boundaries where these occur in the .wav files. phonetic-transcript.txt which has the form "[wav_filename]" "[Phoneme Sequence]" in every line. orthographic-transcript.txt which has the form "[wav_filename]" "[Orthographic Transcript]" in every line. Orthography is in Buckwalter Format which is friendlier where there is software that does not read Arabic script. It can be easily converted back to Arabic. There is an extra 18 minutes of fully annotated corpus (separate from above but with the same structure as above) which was used to evaluated the corpus (see PhD thesis). The corpus was also used to prove that using automatically extracted, orthography-based stress marks improve the quality of speech synthesis in MSA.
C4.5 algorithm
C4.5 is an algorithm used to generate a decision tree developed by Ross Quinlan. C4.5 is an extension of Quinlan's earlier ID3 algorithm. The decision trees generated by C4.5 can be used for classification, and for this reason, C4.5 is often referred to as a statistical classifier. In 2011, authors of the Weka machine learning software described the C4.5 algorithm as "a landmark decision tree program that is probably the machine learning workhorse most widely used in practice to date". It became quite popular after ranking #1 in the Top 10 Algorithms in Data Mining pre-eminent paper published by Springer LNCS in 2008. == Algorithm == C4.5 builds decision trees from a set of training data in the same way as ID3, using the concept of information entropy. The training data is a set S = s 1 , s 2 , . . . {\displaystyle S={s_{1},s_{2},...}} of already classified samples. Each sample s i {\displaystyle s_{i}} consists of a p-dimensional vector ( x 1 , i , x 2 , i , . . . , x p , i ) {\displaystyle (x_{1,i},x_{2,i},...,x_{p,i})} , where the x j {\displaystyle x_{j}} represent attribute values or features of the sample, as well as the class in which s i {\displaystyle s_{i}} falls. At each node of the tree, C4.5 chooses the attribute of the data that most effectively splits its set of samples into subsets enriched in one class or the other. The splitting criterion is the normalized information gain (difference in entropy). The attribute with the highest normalized information gain is chosen to make the decision. The C4.5 algorithm then recurses on the partitioned sublists. This algorithm has a few base cases. All the samples in the list belong to the same class. When this happens, it simply creates a leaf node for the decision tree saying to choose that class. None of the features provide any information gain. In this case, C4.5 creates a decision node higher up the tree using the expected value of the class. Instance of previously unseen class encountered. Again, C4.5 creates a decision node higher up the tree using the expected value. === Pseudocode === In pseudocode, the general algorithm for building decision trees is: Check for the above base cases. For each attribute a, find the normalized information gain ratio from splitting on a. Let a_best be the attribute with the highest normalized information gain. Create a decision node that splits on a_best. Recurse on the sublists obtained by splitting on a_best, and add those nodes as children of node. == Improvements from ID3 algorithm == C4.5 made a number of improvements to ID3. Some of these are: Handling both continuous and discrete attributes: In order to handle continuous attributes, C4.5 creates a threshold and then splits the list into those whose attribute value is above the threshold and those that are less than or equal to it. Handling training data with missing attribute values: C4.5 allows attribute values to be marked as missing. Missing attribute values are simply not used in gain and entropy calculations. Handling attributes with differing costs. Pruning trees after creation: C4.5 goes back through the tree once it's been created and attempts to remove branches that do not help by replacing them with leaf nodes. == Improvements in C5.0/See5 algorithm == Quinlan went on to create C5.0 and See5 (C5.0 for Unix/Linux, See5 for Windows) which he markets commercially. C5.0 offers a number of improvements on C4.5. Some of these are: Speed - C5.0 is significantly faster than C4.5 (several orders of magnitude) Memory usage - C5.0 is more memory efficient than C4.5 Smaller decision trees - C5.0 gets similar results to C4.5 with considerably smaller decision trees. Support for boosting - Boosting improves the trees and gives them more accuracy. Weighting - C5.0 allows you to weight different cases and misclassification types. Winnowing - a C5.0 option automatically winnows the attributes to remove those that may be unhelpful. Source for a single-threaded Linux version of C5.0 is available under the GNU General Public License (GPL).
Multimodal learning
Multimodal learning is a type of deep learning that integrates and processes multiple types of data, referred to as modalities, such as text, audio, images, or video. This integration allows for a more holistic understanding of complex data, improving model performance in tasks like visual question answering, cross-modal retrieval, text-to-image generation, aesthetic ranking, and image captioning. Multimodal learning was proposed in 2011 at the beginning of the deep learning period. Large multimodal models, such as Google Gemini and GPT-4o, have become increasingly popular since 2023, enabling increased versatility and a broader understanding of real-world phenomena. == Motivation == Data usually comes with different modalities which carry different information. For example, it is very common to caption an image to convey the information not presented in the image itself. Similarly, sometimes it is more straightforward to use an image to describe information which may not be obvious from text. As a result, if different words appear in similar images, then these words likely describe the same thing. Conversely, if a word is used to describe seemingly dissimilar images, then these images may represent the same object. Thus, in cases dealing with multi-modal data, it is important to use a model which is able to jointly represent the information such that the model can capture the combined information from different modalities. == Multimodal transformers == Models such as CLIP (Contrastive Language–Image Pretraining) learn joint representations of images and text by optimizing contrastive objectives, allowing the model to match images with their corresponding textual descriptions. == Multimodal deep Boltzmann machines == A Boltzmann machine is a type of stochastic neural network invented by Geoffrey Hinton and Terry Sejnowski in 1985. Boltzmann machines can be seen as the stochastic, generative counterpart of Hopfield nets. They are named after the Boltzmann distribution in statistical mechanics. The units in Boltzmann machines are divided into two groups: visible units and hidden units. Each unit is like a neuron with a binary output that represents whether it is activated or not. General Boltzmann machines allow connection between any units. However, learning is impractical using general Boltzmann Machines because the computational time is exponential to the size of the machine. A more efficient architecture is called restricted Boltzmann machine where connection is only allowed between hidden unit and visible unit, which is described in the next section. Multimodal deep Boltzmann machines can process and learn from different types of information, such as images and text, simultaneously. This can notably be done by having a separate deep Boltzmann machine for each modality, for example one for images and one for text, joined at an additional top hidden layer. == Applications == Multimodal machine learning has numerous applications across various domains: Cross-modal retrieval: cross-modal retrieval allows users to search for data across different modalities (e.g., retrieving images based on text descriptions), improving multimedia search engines and content recommendation systems. Classification and missing data retrieval: multimodal Deep Boltzmann Machines outperform traditional models like support vector machines and latent Dirichlet allocation in classification tasks and can predict missing data in multimodal datasets, such as images and text. Healthcare diagnostics: multimodal models integrate medical imaging, genomic data, and patient records to improve diagnostic accuracy and early disease detection, especially in cancer screening. Content generation: models like DALL·E generate images from textual descriptions, benefiting creative industries, while cross-modal retrieval enables dynamic multimedia searches. Robotics and human-computer interaction: multimodal learning improves interaction in robotics and AI by integrating sensory inputs like speech, vision, and touch, aiding autonomous systems and human-computer interaction. Emotion recognition: combining visual, audio, and text data, multimodal systems enhance sentiment analysis and emotion recognition, applied in customer service, social media, and marketing.
Quantum artificial life
Quantum artificial life is the application of quantum algorithms with the ability to simulate biological behavior. Quantum computers offer many potential improvements to processes performed on classical computers, including machine learning and artificial intelligence. Artificial intelligence applications are often inspired by the idea of mimicking human brains through closely related biomimicry. This has been implemented to a certain extent on classical computers (using neural networks), but quantum computers offer many advantages in the simulation of artificial life. Artificial life and artificial intelligence are extremely similar, with minor differences; the goal of studying artificial life is to understand living beings better, while the goal of artificial intelligence is to create intelligent beings. In 2016, Alvarez-Rodriguez et al. developed a proposal for a quantum artificial life algorithm with the ability to simulate life and Darwinian evolution. In 2018, the same research team led by Alvarez-Rodriguez performed the proposed algorithm on the IBM ibmqx4 quantum computer, and received optimistic results. The results accurately simulated a system with the ability to undergo self-replication at the quantum scale. == Artificial life on quantum computers == The growing advancement of quantum computers has led researchers to develop quantum algorithms for simulating life processes. Researchers have designed a quantum algorithm that can accurately simulate Darwinian Evolution. Since the complete simulation of artificial life on quantum computers has only been actualized by one group, this section shall focus on the implementation by Alvarez-Rodriguez, Sanz, Lomata, and Solano on an IBM quantum computer. Individuals were realized as two qubits, one representing the genotype of the individual and the other representing the phenotype. The genotype is copied to transmit genetic information through generations, and the phenotype is dependent on the genetic information as well as the individual's interactions with their environment. In order to set up the system, the state of the genotype is instantiated by some rotation of an ancillary state ( | 0 ⟩ ⟨ 0 | {\displaystyle |0\rangle \langle 0|} ). The environment is a two-dimensional spatial grid occupied by individuals and ancillary states. The environment is divided into cells that are able to possess one or more individuals. Individuals move throughout the grid and occupy cells randomly; when two or more individuals occupy the same cell they interact with each other. === Self replication === The ability to self-replicate is critical for simulating life. Self-replication occurs when the genotype of an individual interacts with an ancillary state, creating a genotype for a new individual; this genotype interacts with a different ancillary state in order to create the phenotype. During this interaction, one would like to copy some information about the initial state into the ancillary state, but by the no cloning theorem, it is impossible to copy an arbitrary unknown quantum state. However, physicists have derived different methods for quantum cloning which does not require the exact copying of an unknown state. The method that has been implemented by Alvarez-Rodriguez et al. is one that involves the cloning of the expectation value of some observable. For a unitary U {\displaystyle U} which copies the expectation value of some set of observables X {\displaystyle {\mathsf {X}}} of state ρ {\displaystyle \rho } into a blank state ρ e {\displaystyle \rho _{e}} , the cloning machine is defined by any ( U , ρ e , X ) {\displaystyle (U,\rho _{e},{\mathsf {X}})} that fulfill the following: ∀ ρ ∀ X ∈ X {\displaystyle \forall \rho \forall X\in {\mathsf {X}}} X ¯ = X 1 ¯ = X 2 ¯ {\displaystyle {\bar {X}}={\bar {X_{1}}}={\bar {X_{2}}}} Where X ¯ {\displaystyle {\bar {X}}} is the mean value of the observable in ρ {\displaystyle \rho } before cloning, X 1 ¯ {\displaystyle {\bar {X_{1}}}} is the mean value of the observable in ρ {\displaystyle \rho } after cloning, and X 2 ¯ {\displaystyle {\bar {X_{2}}}} is the mean value of the observable in ρ e {\displaystyle \rho _{e}} after cloning. Note that the cloning machine has no dependence on ρ {\displaystyle \rho } because we want to be able to clone the expectation of the observables for any initial state. It is important to note that cloning the mean value of the observable transmits more information than is allowed classically. The calculation of the mean value is defined naturally as: X ¯ = T r [ ρ X ] {\displaystyle {\bar {X}}=Tr[\rho X]} , X 1 ¯ = T r [ R X ⊗ I ] {\displaystyle {\bar {X_{1}}}=Tr[RX\otimes I]} , X 2 ¯ = T r [ R I ⊗ X ] {\displaystyle {\bar {X_{2}}}=Tr[RI\otimes X]} where R = U ρ ⊗ ρ e U † {\displaystyle R=U\rho \otimes \rho _{e}U^{\dagger }} The simplest cloning machine clones the expectation value of σ z {\displaystyle \sigma _{z}} in arbitrary state ρ = | ψ ⟩ ⟨ ψ | {\displaystyle \rho =|\psi \rangle \langle \psi |} to ρ e = | 0 ⟩ ⟨ 0 | {\displaystyle \rho _{e}=|0\rangle \langle 0|} using U = C N O T {\displaystyle U=CNOT} . This is the cloning machine implemented for self-replication by Alvarez-Rodriguez et al. The self-replication process clearly only requires interactions between two qubits, and therefore this cloning machine is the only one necessary for self replication. === Interactions === Interactions occur between individuals when the two take up the same space on the environmental grid. The presence of interactions between individuals provides an advantage for shorter-lifespan individuals. When two individuals interact, exchanges of information between the two phenotypes may or may not occur based on their existing values. When both individual's control qubits (genotypes) are alike, no information will be exchanged. When the control qubits differ, the target qubits (phenotype) will be exchanged between the two individuals. This procedure produces a constantly changing predator-prey dynamic in the simulation. Therefore, long-living qubits, with a larger genetic makeup in the simulation, are at a disadvantage. Since information is only exchanged when interacting with an individual of different genetic makeup, the short-lived population has the advantage. === Mutation === Mutations exist in the artificial world with limited probability, equivalent to their occurrence in the real world. There are two ways in which the individual can mutate: through random single qubit rotations and by errors in the self-replication process. There are two different operators that act on the individual and cause mutations. The M operation causes a spontaneous mutation within the individual by rotating a single qubit by parameter θ. The parameter θ is random for each mutation, which creates biodiversity within the artificial environment. The M operation is a unitary matrix which can be described as: M = ( cos ( θ ) s i n ( θ ) s i n ( θ ) − c o s ( θ ) ) {\displaystyle M={\begin{pmatrix}\cos(\theta )&sin(\theta )\\sin(\theta )&-cos(\theta )\end{pmatrix}}} The other possible way for mutations to occur is due to errors in the replication process. Due to the no-cloning theorem, it is impossible to produce perfect copies of systems that are originally in unknown quantum states. However, quantum cloning machines make it possible to create imperfect copies of quantum states, in other words, the process introduces some degree of error. The error that exists in current quantum cloning machines is the root cause for the second kind of mutations in the artificial life experiment. The imperfect cloning operation can be seen as: U M ( θ ) = I 4 + 1 2 ( 0 0 0 1 ) ⊗ ( − 1 1 1 − 1 ) ( c o s θ + i s i n θ + 1 ) {\displaystyle U_{M}(\theta )=\mathrm {I} _{4}+{\frac {1}{2}}{\begin{pmatrix}0&0\\0&1\end{pmatrix}}\otimes {\begin{pmatrix}-1&1\\1&-1\end{pmatrix}}(cos\theta +isin\theta +1)} The two kinds of mutations affect the individual differently. While the spontaneous M operation does not affect the phenotype of the individual, the self-replicating error mutation, UM, alters both the genotype of the individual, and its associated lifetime. The presence of mutations in the quantum artificial life experiment is critical for providing randomness and biodiversity. The inclusion of mutations helps to increase the accuracy of the quantum algorithm. === Death === At the instant the individual is created (when the genotype is copied into the phenotype), the phenotype interacts with the environment. As time evolves, the interaction of the individual with the environment simulates aging which eventually leads to the death of the individual. The death of an individual occurs when the expectation value of σ z {\displaystyle \sigma _{z}} is within some ϵ {\displaystyle \epsilon } of 1 in the phenotype, or, equivalently, when ρ p = | 0 ⟩ ⟨ 0 | {\displaystyle \rho _{p}=|0\rangle \langle 0|} The Lindbladian describes the interaction of the individual with the environment: ρ
Statistical classification
When classification is performed by a computer, statistical methods are normally used to develop the algorithm. Often, the individual observations are analyzed into a set of quantifiable properties, known variously as explanatory variables or features. These properties may variously be categorical (e.g. "A", "B", "AB" or "O", for blood type), ordinal (e.g. "large", "medium" or "small"), integer-valued (e.g. the number of occurrences of a particular word in an email) or real-valued (e.g. a measurement of blood pressure). Other classifiers work by comparing observations to previous observations by means of a similarity or distance function. An algorithm that implements classification, especially in a concrete implementation, is known as a classifier. The term "classifier" sometimes also refers to the mathematical function, implemented by a classification algorithm, that maps input data to a category. Terminology across fields is quite varied. In statistics, where classification is often done with logistic regression or a similar procedure, the properties of observations are termed explanatory variables (or independent variables, regressors, etc.), and the categories to be predicted are known as outcomes, which are considered to be possible values of the dependent variable. In machine learning, the observations are often known as instances, the explanatory variables are termed features (grouped into a feature vector), and the possible categories to be predicted are classes. Other fields may use different terminology: e.g. in community ecology, the term "classification" normally refers to cluster analysis. == Relation to other problems == Classification and clustering are examples of the more general problem of pattern recognition, which is the assignment of some sort of output value to a given input value. Other examples are regression, which assigns a real-valued output to each input; sequence labeling, which assigns a class to each member of a sequence of values (for example, part of speech tagging, which assigns a part of speech to each word in an input sentence); parsing, which assigns a parse tree to an input sentence, describing the syntactic structure of the sentence; etc. A common subclass of classification is probabilistic classification. Algorithms of this nature use statistical inference to find the best class for a given instance. Unlike other algorithms, which simply output a "best" class, probabilistic algorithms output a probability of the instance being a member of each of the possible classes. The best class is normally then selected as the one with the highest probability. However, such an algorithm has numerous advantages over non-probabilistic classifiers: It can output a confidence value associated with its choice (in general, a classifier that can do this is known as a confidence-weighted classifier). Correspondingly, it can abstain when its confidence of choosing any particular output is too low. Because of the probabilities which are generated, probabilistic classifiers can be more effectively incorporated into larger machine-learning tasks, in a way that partially or completely avoids the problem of error propagation. == Frequentist procedures == Early work on statistical classification was undertaken by Fisher, in the context of two-group problems, leading to Fisher's linear discriminant function as the rule for assigning a group to a new observation. This early work assumed that data-values within each of the two groups had a multivariate normal distribution. The extension of this same context to more than two groups has also been considered with a restriction imposed that the classification rule should be linear. Later work for the multivariate normal distribution allowed the classifier to be nonlinear: several classification rules can be derived based on different adjustments of the Mahalanobis distance, with a new observation being assigned to the group whose centre has the lowest adjusted distance from the observation. == Bayesian procedures == Unlike frequentist procedures, Bayesian classification procedures provide a natural way of taking into account any available information about the relative sizes of the different groups within the overall population. Bayesian procedures tend to be computationally expensive and, in the days before Markov chain Monte Carlo computations were developed, approximations for Bayesian clustering rules were devised. Some Bayesian procedures involve the calculation of group-membership probabilities: these provide a more informative outcome than a simple attribution of a single group-label to each new observation. == Binary and multiclass classification == Classification can be thought of as two separate problems – binary classification and multiclass classification. In binary classification, a better understood task, only two classes are involved, whereas multiclass classification involves assigning an object to one of several classes. Since many classification methods have been developed specifically for binary classification, multiclass classification often requires the combined use of multiple binary classifiers. == Feature vectors == Most algorithms describe an individual instance whose category is to be predicted using a feature vector of individual, measurable properties of the instance. Each property is termed a feature, also known in statistics as an explanatory variable (or independent variable, although features may or may not be statistically independent). Features may variously be binary (e.g. "on" or "off"); categorical (e.g. "A", "B", "AB" or "O", for blood type); ordinal (e.g. "large", "medium" or "small"); integer-valued (e.g. the number of occurrences of a particular word in an email); or real-valued (e.g. a measurement of blood pressure). If the instance is an image, the feature values might correspond to the pixels of an image; if the instance is a piece of text, the feature values might be occurrence frequencies of different words. Some algorithms work only in terms of discrete data and require that real-valued or integer-valued data be discretized into groups (e.g. less than 5, between 5 and 10, or greater than 10). == Linear classifiers == A large number of algorithms for classification can be phrased in terms of a linear function that assigns a score to each possible category k by combining the feature vector of an instance with a vector of weights, using a dot product. The predicted category is the one with the highest score. This type of score function is known as a linear predictor function and has the following general form: score ( X i , k ) = β k ⋅ X i , {\displaystyle \operatorname {score} (\mathbf {X} _{i},k)={\boldsymbol {\beta }}_{k}\cdot \mathbf {X} _{i},} where Xi is the feature vector for instance i, βk is the vector of weights corresponding to category k, and score(Xi, k) is the score associated with assigning instance i to category k. In discrete choice theory, where instances represent people and categories represent choices, the score is considered the utility associated with person i choosing category k. Algorithms with this basic setup are known as linear classifiers. What distinguishes them is the procedure for determining (training) the optimal weights/coefficients and the way that the score is interpreted. Examples of such algorithms include Logistic regression – Statistical model for a binary dependent variable Multinomial logistic regression – Regression for more than two discrete outcomes Probit regression – Statistical regression where the dependent variable can take only two valuesPages displaying short descriptions of redirect targets The perceptron algorithm Support vector machine – Set of methods for supervised statistical learning Linear discriminant analysis – Method used in statistics, pattern recognition, and other fields == Algorithms == Since no single form of classification is appropriate for all data sets, a large toolkit of classification algorithms has been developed. The most commonly used include: Artificial neural networks – Computational model used in machine learningPages displaying short descriptions of redirect targets Boosting (machine learning) – Ensemble learning method Random forest – Tree-based ensemble machine learning methods Genetic programming – Evolving computer programs with techniques analogous to natural genetic processes Gene expression programming – Evolutionary algorithm Multi expression programming Linear genetic programming Kernel estimation – Concept in statisticsPages displaying short descriptions of redirect targets k-nearest neighbor – Non-parametric classification methodPages displaying short descriptions of redirect targets Learning vector quantization Linear classifier – Statistical classification in machine learning Fisher's linear discriminant – Method used in statistics, pattern recognition, and other fieldsPages displaying short descriptions of redirect targets Logistic r