Sophia Ananiadou is a Greek-British computer scientist and computational linguist. She led the development of and directs the National Centre for Text Mining (NaCTeM) in the United Kingdom. She is also Professor in Computer Science in the Department of Computer Science at the University of Manchester. Her research focusses on biomedical text mining and natural language processing and has fed into the development of numerous applications that, for example, facilitate the discovery of new knowledge, enable exploration of historical archives, allow semantic search of biomedical literature, reduce human effort in screening search hits for production of systematic reviews, enable enrichment of metabolic pathway models with evidence from the literature, allow discovery of risk in the construction industry from health and safety incident reports and enable interoperability of components in text mining workflows. == Education == Ananiadou was educated at the Lycée français St Joseph in Athens, Greece (1969–1975). She received a Bachelor of Arts (Ptychion) from the University of Athens (1979), a Master of Advanced Studies (DEA) in Linguistics from Paris VII, Jussieu, France (1980), a DEA in Literature from Paris IV, Sorbonne, France (1984) and a PhD in Computational linguistics from the University of Manchester Institute of Science and Technology (UMIST), in 1988. == Career and research == Ananiadou was a research assistant at Dalle Molle Institute for Semantic and Cognitive Studies (ISSCO, 1983–1984), a research assistant (1985–1988) then research associate (1988–1993) in the department of language engineering at UMIST, senior lecturer at Manchester Metropolitan University (1993–1999), senior lecturer then reader in the School of Computing Science and Engineering, University of Salford (2000–2005), then reader in the School of Computer Science, University of Manchester (2005–2009). Since 2009, she has served as professor in computer science in the Department of Computer Science at the University of Manchester. In July 2025, she became deputy director of the Christabel Pankhurst Institute for health technology research and innovation, University of Manchester. From 2018–2026, she served as the deputy director of the Institute for Data Science and Artificial Intelligence, University of Manchester. She is a senior lead researcher of the ARCHIMEDES research unit of the Athena Research Centre, Greece. ARCHIMEDES is a research and innovation hub fostering international collaboration and knowledge exchange on Artificial Intelligence and Data Science. On February 7, 2025, she was appointed a member of the Artificial Intelligence Sectoral Scientific Council of the Greek Ministry of Development (announcement of appointment in Greek). She is also a Visiting Distinguished Research Fellow in the Knowledge and Information Research Team at the Artificial Intelligence Research Center (AIRC), Japan, which is a research unit of the Japanese National Institute of Advanced Industrial Science and Technology (AIST). In addition, she was appointed to the honorary position of Adjunct Professor of Wuhan University, People's Republic of China, for the period October 2025 to October 2028, collaborating with the School of Artificial Intelligence. Ananiadou has published since 1986, has an h-index of 81 and a Research.com United Kingdom ranking in Computer Science of 104. She is also ranked number 1 internationally in text mining by ScholarGPS. In addition, she is included in the Stanford/Elsevier Top 2% Scientist Rankings for 2025. Ananiadou received a Diplôme de traducteur (Diploma of Translator) from the Institut français d'Athènes, Greece (1979) and a Certificate in Counselling from the University of Salford, UK (2004). === Awards and honours === In 2019, in recognition of her contributions in Artificial Intelligence and text mining for Biomedicine, Ananiadou received an honorary doctorate from the University of the Aegean, on the 20th anniversary of its Department of Mediterranean Studies, Rhodes. Ananiadou received the Unstructured Information Management Architecture (UIMA) innovation award from IBM three years running (2006, 2007 & 2008). She was awarded the Daiwa Adrian Prize in 2004 and also received a Japan Trust award from the Ministry of Education, Japan in 1997. Ananiadou was a Turing Fellow of the Alan Turing Institute in London from 2018 to 2023. Since 2021, she is a member and, since 2024, a Fellow, of the ELLIS Society, the professional society of the cross-national European Laboratory for Learning and Intelligent Systems. Ananiadou served as vice president (VP) of the European Association for Terminology from 1997 to 1999. At the 28th International Conference on Computational Linguistics (COLING 2020), she received, with M. Li and H. Takamura, an Outstanding Paper designation for the paper "A Neural Model for Aggregating Coreference Annotation in Crowdsourcing".
Shepp–Logan phantom
The Shepp–Logan phantom is a standard test image created by Larry Shepp and Benjamin F. Logan for their 1974 paper "The Fourier Reconstruction of a Head Section". It serves as the model of a human head in the development and testing of image reconstruction algorithms. == Definition == The function describing the phantom is defined as the sum of 10 ellipses inside a 2×2 square:
Cut, copy, and paste
Cut, copy, and paste are essential commands of modern human–computer interaction and user interface design. They offer an interprocess communication technique for transferring data through a computer's user interface. The cut command removes the selected data from its original position, and the copy command creates a duplicate; in both cases the selected data is kept in temporary storage called the clipboard. Clipboard data is later inserted wherever a paste command is issued. The data remains available to any application supporting the feature, thus allowing easy data transfer between applications. The command names are a (skeuomorphic) interface metaphor based on the physical procedure used in manuscript print editing to create a page layout, like with paper. The commands were pioneered into computing by Xerox PARC in 1974, popularized by Apple Computer in the 1983 Lisa workstation and the 1984 Macintosh computer, and in a few home computer applications such as the 1984 word processor Cut & Paste. This interaction technique has close associations with related techniques in graphical user interfaces (GUIs) that use pointing devices such as a computer mouse (by drag and drop, for example). Typically, clipboard support is provided by an operating system as part of its GUI and widget toolkit. The capability to replicate information with ease, changing it between contexts and applications, involves privacy concerns because of the risks of disclosure when handling sensitive information. Terms like cloning, copy forward, carry forward, or re-use refer to the dissemination of such information through documents, and may be subject to regulation by administrative bodies. == History == === Origins === The term "cut and paste" comes from the traditional practice in manuscript editing, whereby people cut paragraphs from a page with scissors and paste them onto another page. This practice remained standard into the 1980s. Stationery stores sold "editing scissors" with blades long enough to cut an 8½"-wide page. The advent of photocopiers made the practice easier and more flexible. The act of copying or transferring text from one part of a computer-based document ("buffer") to a different location within the same or different computer-based document was a part of the earliest on-line computer editors. As soon as computer data entry moved from punch-cards to online files (in the mid/late 1960s) there were "commands" for accomplishing this operation. This mechanism was often used to transfer frequently-used commands or text snippets from additional buffers into the document, as was the case with the QED text editor. === Early methods === The earliest editors (designed for teleprinter terminals) provided keyboard commands to delineate a contiguous region of text, then delete or move it. Since moving a region of text requires first removing it from its initial location and then inserting it into its new location, various schemes had to be invented to allow for this multi-step process to be specified by the user. Often this was done with a "move" command, but some text editors required that the text be first put into some temporary location for later retrieval/placement. In 1983, the Apple Lisa became the first text editing system to call that temporary location "the clipboard". Earlier control schemes such as NLS used a verb—object command structure, where the command name was provided first and the object to be copied or moved was second. The inversion from verb—object to object—verb on which copy and paste are based, where the user selects the object to be operated before initiating the operation, was an innovation crucial for the success of the desktop metaphor as it allowed copy and move operations based on direct manipulation. === Popularization === Inspired by early line and character editors, such as Pentti Kanerva's TV-Edit, that broke a move or copy operation into two steps—between which the user could invoke a preparatory action such as navigation—Lawrence G. "Larry" Tesler proposed the names "cut" and "copy" for the first step and "paste" for the second step. Beginning in 1974, he and colleagues at Xerox PARC implemented several text editors that used cut/copy-and-paste commands to move and copy text. Apple Computer popularized this paradigm with its Lisa (1983) and Macintosh (1984) operating systems and applications. The functions were mapped to key combinations using the ⌘ Command key as a special modifier, which is held down while also pressing X for cut, C for copy, or V for paste. These few keyboard shortcuts allow the user to perform all the basic editing operations, and the keys are clustered at the left end of the bottom row of the standard QWERTY keyboard. These are the standard shortcuts: Control-Z (or ⌘ Command+Z) to undo Control-X (or ⌘ Command+X) to cut Control-C (or ⌘ Command+C) to copy Control-V (or ⌘ Command+V) to paste The IBM Common User Access (CUA) standard also uses combinations of the Insert, Del, Shift and Control keys. Early versions of Windows used the IBM standard. Microsoft later also adopted the Apple key combinations with the introduction of Windows, using the control key as modifier key. Similar patterns of key combinations, later borrowed by others, are widely available in most GUI applications. The original cut, copy, and paste workflow, as implemented at PARC, utilizes a unique workflow: With two windows on the same screen, the user could use the mouse to pick a point at which to make an insertion in one window (or a segment of text to replace). Then, by holding shift and selecting the copy source elsewhere on the same screen, the copy would be made as soon as the shift was released. Similarly, holding shift and control would copy and cut (delete) the source. This workflow requires many fewer keystrokes/mouse clicks than the current multi-step workflows, and did not require an explicit copy buffer. It was dropped, one presumes, because the original Apple and IBM GUIs were not high enough density to permit multiple windows, as were the PARC machines, and so multiple simultaneous windows were rarely used. == Cut and paste == Computer-based editing can involve very frequent use of cut-and-paste operations. Most software-suppliers provide several methods for performing such tasks, and this can involve (for example) key combinations, pulldown menus, pop-up menus, or toolbar buttons. The user selects or "highlights" the text or file for moving by some method, typically by dragging over the text or file name with the pointing-device or holding down the Shift key while using the arrow keys to move the text cursor. The user performs a "cut" operation via key combination Ctrl+x (⌘+x for Macintosh users), menu, or other means. Visibly, "cut" text immediately disappears from its location. "Cut" files typically change color to indicate that they will be moved. Conceptually, the text has now moved to a location often called the clipboard. The clipboard typically remains invisible. On most systems only one clipboard location exists, hence another cut or copy operation overwrites the previously stored information. Many UNIX text-editors provide multiple clipboard entries, as do some Macintosh programs such as Clipboard Master, and Windows clipboard-manager programs such as the one in Microsoft Office. The user selects a location for insertion by some method, typically by clicking at the desired insertion point. A paste operation takes place which visibly inserts the clipboard text at the insertion point. (The paste operation does not typically destroy the clipboard text: it remains available in the clipboard and the user can insert additional copies at other points). Whereas cut-and-paste often takes place with a mouse-equivalent in Windows-like GUI environments, it may also occur entirely from the keyboard, especially in UNIX text editors, such as Pico or vi. Cutting and pasting without a mouse can involve a selection (for which Ctrl+x is pressed in most graphical systems) or the entire current line, but it may also involve text after the cursor until the end of the line and other more sophisticated operations. The clipboard usually stays invisible, because the operations of cutting and pasting, while actually independent, usually take place in quick succession, and the user (usually) needs no assistance in understanding the operation or maintaining mental context. Some application programs provide a means of viewing, or sometimes even editing, the data on the clipboard. == Copy and paste == The term "copy-and-paste" refers to the popular, simple method of reproducing text or other data from a source to a destination. It differs from cut and paste in that the original source text or data does not get deleted or removed. The popularity of this method stems from its simplicity and the ease with which users can move data between various applications visually – without resorting to permanent storage. Use in healthcare do
AS2
AS2 (Applicability Statement 2) is a specification on how to transport structured business-to-business data securely and reliably over the Internet. Security is achieved by using digital certificates and encryption. == Background == AS2 was created in 2002 by the IETF to replace AS1, which they created in the early 1990s. The adoption of AS2 grew rapidly throughout the early 2000s because major players in the retail and fast-moving consumer goods industries championed AS2. Walmart was the first major retailer to require its suppliers to use the AS2 protocol instead of relying on dial-up modems for ordering goods. Amazon, Target, Lowe's, Bed, Bath, & Beyond and thousands of others followed suit. Many other industries use the AS2 protocol, including healthcare, as AS2 meets legal HIPAA requirements. In some cases, AS2 is a way to bypass expensive value-added networks previously used for data interchange. == Technical overview == AS2 is specified in RFC 4130, and is based on HTTP and S/MIME. It was the second AS protocol developed and uses the same signing, encryption and MDN (as defined by RFC3798) conventions used in the original AS1 protocol introduced in the late 1990s by IETF. In other words: Files are encoded as "attachments" in a standardized S/MIME message (an AS2 message). AS2 does not specify the contents of the files. Usually, the file contents are in a standardized format that is separately agreed upon, such as XML or EDIFACT. AS2 messages are always sent using the HTTP or HTTPS protocol (Secure Sockets Layer — also known as SSL — is implied by HTTPS) and usually use the "POST" method (use of "GET" is rare). Messages can be signed, but do not have to be. Messages can be encrypted, but do not have to be. Messages may request a Message Disposition Notification (MDN) back if all went well, but do not have to request such a message. If the original AS2 message requested an MDN: Upon the receipt of the message and its successful decryption or signature validation (as necessary) a "success" MDN will be sent back to the original sender. This MDN is typically signed but never encrypted (unless temporarily encrypted in transit via HTTPS). Upon the receipt and successful verification of the signature on the MDN, the original sender will "know" that the recipient got their message (this provides the "Non-repudiation" element of AS2). If there are any problems receiving or interpreting the original AS2 message, a "failed" MDN may be sent back. However, part of the AS2 protocol states that the client must treat a lack of an MDN as a failure as well, so some AS2 receivers will not return an MDN in this case. Like any other AS file transfer, AS2 file transfers typically require both sides of the exchange to trade X.509 certificates and specific "trading partner" names before any transfers can take place. AS2 trading partner names can usually be any valid phrase. === MDN options === Unlike AS1 or AS3 file transfers, AS2 file transfers offer several "MDN return" options instead of the traditional options of "yes" or "no". Specifically, the choices are: ==== AS2 w/ "Sync" MDNs ==== Return Synchronous MDN via HTTP(S) ("AS2 Sync") - This popular option allows AS2 MDNs to be returned to AS2 message sender clients over the same HTTP connection they used to send the original message. This "MDN while you wait" capability makes "AS2 Sync" transfers the fastest of any type of AS file transfer, but it also keeps this flavor of MDN requests from being used with large files (which may time out in low-bandwidth situations). ==== AS2 w/ "ASync" MDNs ==== Return Asynchronous MDN via HTTP(S) (a.k.a. "AS2 Async") - This popular option allows AS2 MDNs to be returned to the AS2 message sender's server later over a different HTTP connection. This flavor of MDN request is usually used if large files are involved or if your trading partner's AS2 server has poor Internet service. ==== AS2 w/ "Email" MDNs ==== Return (Asynchronous) MDN via Email - This rarely used option allows AS2 MDNs to be returned to AS2 message senders via email rather than HTTP. Otherwise, it is similar to "AS2 Async (HTTP)". ==== AS2 w/ No MDNs ==== Do not return MDN - This option works like it does in any other AS protocol: the receiver of an AS2 message with this option set simply does not try to return an MDN to the AS2 message sender. ==== Filename preservation ==== AS2 filename preservation feature will be used to communicate the filename to the trading partner. The banking industry relies on filenames being communicated between trading partners. AS2 vendors are currently certifying that implementation of filename communication conforms to the standard and is interoperable. There are two profiles for filename preservation being optionally tested under AS2 testing: Filename preservation without MDN responses Filename preservation with an associated MDN response certification Walmart recommends contacting Drummond Group, LLC for more information on EDIINT AS2, or for a list of interoperable-testing AS2 software providers. == Benefits == For many businesses, the use of AS2 and electronic data interchange (EDI) is not a choice so much as it is a requirement of doing business with a large customer or partner. That said, AS2 is a universal protocol that has benefits, from both business and technology vantage points. === Business case === Cut costs by using the web for EDI file transfers, AS2 reduces the cost of transactions from expensive VANs. Extend EDI to more partners; with lower costs and universal web connectivity, AS2 allows organizations to implement EDI with partners worldwide that have little EDI infrastructure. Save time by eliminating the need to manually process orders. Eliminate errors by turning manual processes into automated processes. Universal solution — AS2 is established and tested, so no one has to re-invent the wheel. === Technological advantages === Leverage the web: if an organization can share data securely via the web, they already have much of the infrastructure for AS2. Unlimited EDI data — there are no practical limitations on transaction sizes via the web, and AS2 includes features for managing large transfers. Payload Agnostic — AS2 can be used to transport any type of document. While EDI X12, EDIFACT and XML are common, any mutually agreed-upon format may be transferred.
Social network hosting service
A social network hosting service is a web hosting service that specifically hosts the user creation of web-based social networking services, alongside related applications. Such services are also known as vertical social networks due to the creation of SNSes which cater to specific user interests and niches; like larger, interest-agnostic SNSes, such niche networking services may also possess the ability to create increasingly niche groups of users. == List of social network hosting services == Federated Media Publishing's BigTent BroadVision Clearvale Ning Wall.fm
Structured sparsity regularization
Structured sparsity regularization is a class of methods, and an area of research in statistical learning theory, that extend and generalize sparsity regularization learning methods. Both sparsity and structured sparsity regularization methods seek to exploit the assumption that the output variable Y {\displaystyle Y} (i.e., response, or dependent variable) to be learned can be described by a reduced number of variables in the input space X {\displaystyle X} (i.e., the domain, space of features or explanatory variables). Sparsity regularization methods focus on selecting the input variables that best describe the output. Structured sparsity regularization methods generalize and extend sparsity regularization methods, by allowing for optimal selection over structures like groups or networks of input variables in X {\displaystyle X} . Common motivation for the use of structured sparsity methods are model interpretability, high-dimensional learning (where dimensionality of X {\displaystyle X} may be higher than the number of observations n {\displaystyle n} ), and reduction of computational complexity. Moreover, structured sparsity methods allow to incorporate prior assumptions on the structure of the input variables, such as overlapping groups, non-overlapping groups, and acyclic graphs. Examples of uses of structured sparsity methods include face recognition, magnetic resonance image (MRI) processing, socio-linguistic analysis in natural language processing, and analysis of genetic expression in breast cancer. == Definition and related concepts == === Sparsity regularization === Consider the linear kernel regularized empirical risk minimization problem with a loss function V ( y i , f ( x ) ) {\displaystyle V(y_{i},f(x))} and the ℓ 0 {\displaystyle \ell _{0}} "norm" as the regularization penalty: min w ∈ R d 1 n ∑ i = 1 n V ( y i , ⟨ w , x i ⟩ ) + λ ‖ w ‖ 0 , {\displaystyle \min _{w\in \mathbb {R} ^{d}}{\frac {1}{n}}\sum _{i=1}^{n}V(y_{i},\langle w,x_{i}\rangle )+\lambda \|w\|_{0},} where x , w ∈ R d {\displaystyle x,w\in \mathbb {R^{d}} } , and ‖ w ‖ 0 {\displaystyle \|w\|_{0}} denotes the ℓ 0 {\displaystyle \ell _{0}} "norm", defined as the number of nonzero entries of the vector w {\displaystyle w} . f ( x ) = ⟨ w , x i ⟩ {\displaystyle f(x)=\langle w,x_{i}\rangle } is said to be sparse if ‖ w ‖ 0 = s < d {\displaystyle \|w\|_{0}=s
Data custodian
In data governance groups, responsibilities for data management are increasingly divided between the business process owners and information technology (IT) departments. Two functional titles commonly used for these roles are data steward and data custodian. Data Stewards are commonly responsible for data content, context, and associated business rules. Data custodians are responsible for the safe custody, transport, storage of the data and implementation of business rules. Simply put, Data Stewards are responsible for what is stored in a data field, while data custodians are responsible for the technical environment and database structure. Common job titles for data custodians are database administrator (DBA), data modeler, ETL developer and data engineer. == Data custodian responsibilities == A data custodian ensures: Access to the data is authorized and controlled Data stewards are identified for each data set Technical processes sustain data integrity Processes exist for data quality issue resolution in partnership with data stewards Technical controls safeguard data Data added to data sets are consistent with the common data model Versions of master data are maintained along with the history of changes Change management practices are applied in maintenance of the database Data content and changes can be audited