Smart-ID is an electronic authentication tool developed by SK ID Solutions, an Estonian company. Users can log in to various electronic services and sign documents with an electronic signature. Smart-ID meets the European Union's eIDAS Regulation and the European Central Bank's standards for a secure authentication solution. Smart-ID is a Qualified Signature Creator Device (QSCD) that can issue a Qualified Electronic Signature (QES). The Smart-ID app is compatible with both iOS and Android devices and does not require a SIM card. By 2021, the Smart-ID application was launched in the Huawei AppGallery. As of May 2023, Smart-ID has 3,298,969 active users across the Baltic States (Latvia, Lithuania, and Estonia). Every month, the Smart-ID processes 79 million transactions. In March 2023, Smart-ID users made an exceptional 85 million transactions. == History == In November 2016, SK ID Solutions debuted the Smart-ID tool for the first time at its annual conference. In February 2017, eKool, Starman, and Tallinn Kaubamaja Grupp were the first to implement Smart-ID authentication in their e-services. In March 2017, Smart-ID was added as an authentication option to SEB bank and Swedbank's online banking in all three Baltic States. Dokobit, previously known as DigiDoc, began offering its clients the ability to use e-services using Smart-ID in April 2017. More than 100 service providers had implemented Smart-ID as an authentication solution for their services by November 2019. At its annual conference on November 8, 2018, SK ID Solutions revealed that Smart-ID had been certified as compatible with the QSCD[8] level, the highest level of qualified electronic signature in the European Union, following a rigorous certification process. As a result, the Smart-QES-level ID's electronic signature, the digital counterpart of a handwritten signature, is now available to all users who have registered with the tool. This signature is accepted by all European Union member states. On August 26, 2019, Estonian Information Systems Supervisory Authority experts reviewed Smart-ID (ISSA). Based on the methods provided in the eIDAS Regulation, the expert committee concluded that Smart-ID offers a high level of electronic identification assurance. SK ID Solutions and RIA struck an agreement in September 2019 that allows Smart-ID to authenticate Estonian state e-services via RIA's central authentication service, which is used by over 60 public authorities. Smart-ID accounts created three years ago have expired in January 2020. Therefore, renewing them and performing mandatory updates was necessary. In February 2020, SK ID Solutions announced that Smart-ID could be used to give digital signatures in the national digital signature software DigiDoc4, which up until this moment was only possible with ID cards via Mobile-ID. Users must have at least version 4.2.4.71 or later of the DigiDoc4 software installed on their computers to use this feature. Since February 2020, Smart-ID accounts can now be created with biometric information from an ID card or passport, but only by users who have previously used a Smart-ID account. Since October 2022, 13–17 years old minors in Lithuania are able to create a Smart-ID account using biometric information too. A parent or legal guardian must approve the registration. SK ID Solutions collaborated on the new solution with iProov from the United Kingdom and InnoValor from the Netherlands. TÜV Informationstechnik GmbH, a German certification company, assessed it. Since May 2023, Smart-ID can be used to submit company's annual reports in Estonia and digitally sign anything in the e-business register using your PIN2. == Overview == The Smart-ID app is available for download on Google Play and Apple's App Store. Android 4.4 and iOS 11 are the oldest supported operating system versions for Smart-ID. Smart-ID works on the premise of two-factor authentication, combining an intelligent device (something the user owns) with PINs (something the user knows). A new user must first authenticate themselves with an ID card or a mobile phone number and then confirm a PIN1 and PIN2 code, either manually or automatically produced. The first PIN is used to authenticate a person's identity when accessing e-banking or e-services, while the second PIN is used to support electronic signatures and authenticate transactions (e.g., transfers). The PIN1 code must be four digits long, while the PIN2 code must be five digits long. To log in to an e-service, the user must use Smart-ID as the authentication method and enter their unique Smart-ID user ID. A notification will open on the user's smart device where the software is installed and display a verification code. If the code matches the code presented to the user by the e-service, then the user can confirm the match by entering their PIN1 code. The user must verify the action with their PIN2 code when giving digital signatures. A Smart-ID account is valid for three years. The report can be updated, changed, and deleted at any given time, free of charge. Smart-ID is available in five languages: Estonian, Latvian, Lithuanian, Russian, and English. An international survey conducted in 2021 revealed that Smart-ID is the most reliable authentication solution in Baltic countries. In January 2023, the number of times Smart-ID was used to access State Authentication Service (TARA) in Estonia has surpassed those of Mobile-ID and ID-cards for the first time since July 2022. == Security == Smart-ID is based on Cybernetica's SplitKey authentication and digital signature platform technology, for which the company has filed a patent application. Public key cryptography, digital signature methods, and critical public infrastructures are all used in the technology. The user's PIN is not saved on the device and is only needed to decrypt the private key in the Smart-ID app. When the user inputs the PIN, the private key is cracked, and the answer is transmitted to the Smart-ID server, where a portion of the key given by the app is joined with the server's encrypted key. The app will block the user from accessing it for three hours if they input the incorrect PIN three times in a row. If this happens once again, the app will lock for 24 hours. If this happens a third time, the account will be permanently disabled. PINs cannot be changed or recovered once an account has been created. The user must create a new account if the account is permanently blocked. Smart-ID uses the Apple and Google messaging networks to notify the app when new data is saved on its servers. == Phishing == In February 2019, unknown criminals attempted to create Smart-ID accounts with stolen IDs obtained via phishing customers' text messages and website addresses, according to a monthly report by the Estonian Information System Manager in April 2019. The Latvian Information Technology Security Incident Assessment Body Cert was also notified of these intrusions on March 1. Fraudsters sent emails to potential victims pretending to be bank representatives. The mails linked users to a phishing page after redirecting them to a phony bank login page. Victims were asked to log in using their identification information and PIN1 code. The fraudsters then began the process of generating a new Smart-ID account. As a result, the victim had to input a PIN2 number, which permitted the fraudster to finish setting up a new tab with the victim's personal information. Fraudsters in Estonia were able to log in to multiple e-services utilizing Smart-ID using a Smart-ID account and the victim's data. On behalf of the victims, fraudsters also employed online banking services. Later, the Estonian Information System Manager identified several victims, some of whom had also experienced financial losses. The Estonian Information System Manager requested a full report on the event from SK ID Solutions. The organization opted not to criticize the corporation after receiving the information, although it did propose that the procedure of creating Smart-ID accounts be reviewed. According to the Estonian Banking Association, Estonian banks have not discontinued using Smart-ID and do not think it is required. Smart-ID was exposed to a thorough review process in September 2019 to determine this authentication instrument's level of security. Reviewers discovered no flaws, and SK ID Solutions and the Estonian Information System Manager signed a contract. Estonia later introduced Smart-ID and other authentication mechanisms to the central public services portal.
Simple interactive object extraction
Simple interactive object extraction (SIOX) is an algorithm for extracting foreground objects from color images and videos with very little user interaction. It has been implemented as "foreground selection" tool in the GIMP (since version 2.3.3), as part of the tracer tool in Inkscape (since 0.44pre3), and as function in ImageJ and Fiji (plug-in). Experimental implementations were also reported for Blender and Krita. Although the algorithm was originally designed for videos, virtually all implementations use SIOX primarily for still image segmentation. In fact, it is often said to be the current de facto standard for this task in the open-source world. Initially, a free hand selection tool is used to specify the region of interest. It must contain all foreground objects to extract and as few background as possible. The pixels outside the region of interest form the sure background while the inner region define a superset of the foreground, i.e. the unknown region. A so-called foreground brush is then used to mark representative foreground regions. The algorithm outputs a selection mask. The selection can be refined by either adding further foreground markings or by adding background markings using the background brush. Technically, the algorithm performs the following steps: Create a set of representative colors for sure foreground and sure background, the so-called color signatures. Assign all image points to foreground or background by a weighted nearest neighbor search in the color signatures. Apply some standard image processing operations like erode, dilate, and blur to remove artifacts. Find the connected foreground components that are either large enough or marked by the user. For video segmentation the sure background and sure foreground regions are learned from motion statistics. SIOX also features tools that allow sub-pixel accurate refinement of edges and high texture areas, the so-called "detail refinement brushes". As with all segmentation algorithms, there are always pictures where the algorithm does not yield perfect results. The most critical drawback of SIOX is the color dependence. Although many photos are well-separable by color, the algorithm cannot deal with camouflage. If the foreground and background share many identical shades of similar colors, the algorithm might give a result with parts missing or incorrectly classified foreground. SIOX performs about equally well on different benchmarks compared to graph-based segmentation methods, such as Grabcut. SIOX is, however, more noise robust and can therefore also be used for the segmentation of videos. Graph-based segmentation methods search for a minimum cut and therefore tend to not perform optimally with complex structures. The algorithm has initially been developed at the department of computer science at Freie Universitaet Berlin. The main developer, Gerald Friedland, is now faculty at the EECS department of the University of California at Berkeley and also a Principal Data Scientist at Lawrence Livermore National Lab. He continues to support the development through mentoring, e.g. in the Google Summer of Code.
DreamBooth
DreamBooth is a deep learning generation model used to personalize existing text-to-image models by fine-tuning. It was developed by researchers from Google Research and Boston University in 2022. Originally developed using Google's own Imagen text-to-image model, DreamBooth implementations can be applied to other text-to-image models, where it can allow the model to generate more fine-tuned and personalized outputs after training on three to five images of a subject. == Technology == Pretrained text-to-image diffusion models, while often capable of offering a diverse range of different image output types, lack the specificity required to generate images of lesser-known subjects, and are limited in their ability to render known subjects in different situations and contexts. The methodology used to run implementations of DreamBooth involves the fine-tuning the full UNet component of the diffusion model using a few images (usually 3--5) depicting a specific subject. Images are paired with text prompts that contain the name of the class the subject belongs to, plus a unique identifier. As an example, a photograph of a [Nissan R34 GTR] car, with car being the class); a class-specific prior preservation loss is applied to encourage the model to generate diverse instances of the subject based on what the model is already trained on for the original class. Pairs of low-resolution and high-resolution images taken from the set of input images are used to fine-tune the super-resolution components, allowing the minute details of the subject to be maintained. == Usage == DreamBooth can be used to fine-tune models such as Stable Diffusion, where it may alleviate a common shortcoming of Stable Diffusion not being able to adequately generate images of specific individual people. Such a use case is quite VRAM intensive, however, and thus cost-prohibitive for hobbyist users. The Stable Diffusion adaptation of DreamBooth in particular is released as a free and open-source project based on the technology outlined by the original paper published by Ruiz et. al. in 2022. Concerns have been raised regarding the ability for bad actors to utilise DreamBooth to generate misleading images for malicious purposes, and that its open-source nature allows anyone to utilise or even make improvements to the technology. In addition, artists have expressed their apprehension regarding the ethics of using DreamBooth to train model checkpoints that are specifically aimed at imitating specific art styles associated with human artists; one such critic is Hollie Mengert, an illustrator for Disney and Penguin Random House who has had her art style trained into a checkpoint model via DreamBooth and shared online, without her consent.
Zvi Mowshowitz
Zvi Mowshowitz is an American writer and member of the rationalist community who primarily discusses new developments in artificial intelligence. He is a former competitive Magic: The Gathering player and was CEO of MetaMed. == Career == Mowshowitz is an alumnus of Columbia University and holds a bachelor's degree in mathematics. He co-founded and was the CEO of MetaMed, a medical research analysis firm. He has worked at Jane Street Capital, and has worked for the gambling industry in Las Vegas. He attempted to launch a blockchain game, Emergents, in 2020. === Magic: The Gathering === Mowshowitz held a developer intern position at Wizards of the Coast R&D in 2005. He created the deck TurboZvi. His first-place finishes at major competitions were the 1999 World Championships as part of the four-person United States national team, the 2001 Pro Tour Tokyo, and two 2003 Grand Prix. He has placed in the top eight of four Pro Tours, and earned over $140,000 playing Magic competitively. In 2007, Mowshowitz was elected into the Magic Hall of Fame. Last updated: 12 May 2013Source: Wizards.com Mowshowitz has written about Magic for several outlets, including the official Magic website. === Later career === Mowshowitz is on the board of directors for the Center for Applied Rationality, and is a member of the rationalist community. He also founded Balsa Research, a nonprofit think tank which advocated for the repeal of the Jones Act, increasing the housing supply, and reform of the National Environmental Policy Act. In 2023, Mowshowitz wrote an article for Vox on the topic of artificial intelligence safety. Mowshowitz has a blog on Substack under the name "Don't Worry about the Vase". He has written on topics such as artificial intelligence, economics, and the COVID-19 pandemic. == Personal life == Mowshowitz is the son of American biochemist Deborah Mowshowitz. His parents have both worked as Columbia University professors.
Pattern language
A pattern language is an organized and coherent set of patterns, each of which describes a problem and the core of a solution that can be used in many ways within a specific field of expertise. The term was coined by architect Christopher Alexander and popularized by his 1977 book A Pattern Language. A pattern language can also be an attempt to express the deeper wisdom of what brings aliveness within a particular field of human endeavor, through a set of interconnected patterns. Aliveness is one placeholder term for "the quality that has no name": a sense of wholeness, spirit, or grace, that while of varying form, is precise and empirically verifiable. Alexander claims that ordinary people can use this design approach to successfully solve very large, complex design problems. == What is a pattern? == When a designer designs something – whether a house, computer program, or lamp – they must make many decisions about how to solve problems. A single problem is documented with its typical place (the syntax), and use (the grammar) with the most common and recognized good solution seen in the wild, like the examples seen in dictionaries. Each such entry is a single design pattern. Each pattern has a name, a descriptive entry, and some cross-references, much like a dictionary entry. A documented pattern should explain why that solution is good in the pattern's contexts. Elemental or universal patterns such as "door" or "partnership" are versatile ideals of design, either as found in experience or for use as components in practice, explicitly described as holistic resolutions of the forces in recurrent contexts and circumstances, whether in architecture, medicine, software development or governance, etc. Patterns might be invented or found and studied, such as the naturally occurring patterns of design that characterize human environments. Like all languages, a pattern language has vocabulary, syntax, and grammar – but a pattern language applies to some complex activity other than communication. In pattern languages for design, the parts break down in this way: The language description – the vocabulary – is a collection of named, described solutions to problems in a field of interest. These are called design patterns. So, for example, the language for architecture describes items like: settlements, buildings, rooms, windows, latches, etc. Each solution includes syntax, a description that shows where the solution fits in a larger, more comprehensive or more abstract design. This automatically links the solution into a web of other needed solutions. For example, rooms have ways to get light, and ways to get people in and out. The solution includes grammar that describes how the solution solves a problem or produces a benefit. So, if the benefit is unneeded, the solution is not used. Perhaps that part of the design can be left empty to save money or other resources; if people do not need to wait to enter a room, a simple doorway can replace a waiting room. In the language description, grammar and syntax cross index (often with a literal alphabetic index of pattern names) to other named solutions, so the designer can quickly think from one solution to related, needed solutions, and document them in a logical way. In Christopher Alexander's book A Pattern Language, the patterns are in decreasing order by size, with a separate alphabetic index. The web of relationships in the index of the language provides many paths through the design process. This simplifies the design work because designers can start the process from any part of the problem they understand and work toward the unknown parts. At the same time, if the pattern language has worked well for many projects, there is reason to believe that even a designer who does not completely understand the design problem at first will complete the design process, and the result will be usable. For example, skiers coming inside must shed snow and store equipment. The messy snow and boot cleaners should stay outside. The equipment needs care, so the racks should be inside. == Many patterns form a language == Just as words must have grammatical and semantic relationships to each other in order to make a spoken language useful, design patterns must be related to each other in position and utility order to form a pattern language. Christopher Alexander's work describes a process of decomposition, in which the designer has a problem (perhaps a commercial assignment), selects a solution, then discovers new, smaller problems resulting from the larger solution. Occasionally, the smaller problems have no solution, and a different larger solution must be selected. Eventually all of the remaining design problems are small enough or routine enough to be solved by improvisation by the builders, and the "design" is done. The actual organizational structure (hierarchical, iterative, etc.) is left to the discretion of the designer, depending on the problem. This explicitly lets a designer explore a design, starting from some small part. When this happens, it's common for a designer to realize that the problem is actually part of a larger solution. At this point, the design almost always becomes a better design. In the language, therefore, each pattern has to indicate its relationships to other patterns and to the language as a whole. This gives the designer using the language a great deal of guidance about the related problems that must be solved. The most difficult part of having an outside expert apply a pattern language is in fact to get a reliable, complete list of the problems to be solved. Of course, the people most familiar with the problems are the people that need a design. So, Alexander famously advocated on-site improvisation by concerned, empowered users, as a powerful way to form very workable large-scale initial solutions, maximizing the utility of a design, and minimizing the design rework. The desire to empower users of architecture was, in fact, what led Alexander to undertake a pattern language project for architecture in the first place. == Design problems in a context == An important aspect of design patterns is to identify and document the key ideas that make a good system different from a poor system (that may be a house, a computer program or an object of daily use), and to assist in the design of future systems. The idea expressed in a pattern should be general enough to be applied in very different systems within its context, but still specific enough to give constructive guidance. The range of situations in which the problems and solutions addressed in a pattern apply is called its context. An important part in each pattern is to describe this context. Examples can further illustrate how the pattern applies to very different situation. For instance, Alexander's pattern "A PLACE TO WAIT" addresses bus stops in the same way as waiting rooms in a surgery, while still proposing helpful and constructive solutions. The "Gang-of-Four" book Design Patterns by Gamma et al. proposes solutions that are independent of the programming language, and the program's application domain. Still, the problems and solutions described in a pattern can vary in their level of abstraction and generality on the one side, and specificity on the other side. In the end this depends on the author's preferences. However, even a very abstract pattern will usually contain examples that are, by nature, absolutely concrete and specific. Patterns can also vary in how far they are proven in the real world. Alexander gives each pattern a rating by zero, one or two stars, indicating how well they are proven in real-world examples. It is generally claimed that all patterns need at least some existing real-world examples. It is, however, conceivable to document yet unimplemented ideas in a pattern-like format. The patterns in Alexander's book also vary in their level of scale – some describing how to build a town or neighbourhood, others dealing with individual buildings and the interior of rooms. Alexander sees the low-scale artifacts as constructive elements of the large-scale world, so they can be connected to a hierarchic network. === Balancing of forces === A pattern must characterize the problems that it is meant to solve, the context or situation where these problems arise, and the conditions under which the proposed solutions can be recommended. Often these problems arise from a conflict of different interests or "forces". A pattern emerges as a dialogue that will then help to balance the forces and finally make a decision. For instance, there could be a pattern suggesting a wireless telephone. The forces would be the need to communicate, and the need to get other things done at the same time (cooking, inspecting the bookshelf). A very specific pattern would be just "WIRELESS TELEPHONE". More general patterns would be "WIRELESS DEVICE" or "SECONDARY ACTIVITY", suggesting that a secondary activity (such as talking on t
Biopython
Biopython is an open-source collection of non-commercial Python modules for computational biology and bioinformatics. It makes robust and well-tested code easily accessible to researchers. Python is an object-oriented programming language and is a suitable choice for automation of common tasks. The availability of reusable libraries saves development time and lets researchers focus on addressing scientific questions. Biopython is constantly updated and maintained by a large team of volunteers across the globe. Biopython contains parsers for diverse bioinformatic sequence, alignment, and structure formats. Sequence formats include FASTA, FASTQ, GenBank, and EMBL. Alignment formats include Clustal, BLAST, PHYLIP, and NEXUS. Structural formats include the PDB, which contains the 3D atomic coordinates of the macromolecules. It has provisions to access information from biological databases like NCBI, Expasy, PBD, and BioSQL. This can be used in scripts or incorporated into their software. Biopython contains a standard sequence class, sequence alignment, and motif analysis tools. It also has clustering algorithms, a module for structural biology, and a module for phylogenetics analysis. == History == The development of Biopython began in 1999, and it was first released in July 2000. First "semi-complete" and "semi-stable" release was done in March 2001 and December 2002 respectively. It was developed during a similar time frame and with analogous goals to other projects that added bioinformatics capabilities to their respective programming languages, including BioPerl, BioRuby and BioJava. Early developers on the project included Jeff Chang, Andrew Dalke and Brad Chapman, though over 100 people have made contributions to date. In 2007, a similar Python project, namely PyCogent, was established. The initial scope of Biopython involved accessing, indexing and processing biological sequence files. The retrieved data from common biological databases will then be parsed into a python data structure. While this is still a major focus, over the following years added modules have extended its functionality to cover additional areas of biology. The key challenge in the design of parsers for bioinformatics file formats is the frequency at which the data formats change. This is due to inadequate curation of the structure of the data, and changes in the database contents. This problem is overcome by the application of a standard event-oriented parser design (see Key features and examples). As of version 1.77, Biopython no longer supports Python 2. The current stable release of Biopython version 1.85 was released on 15 January 2025. It only supports Python 3 and the recent releases of Biopython require NumPy (and not Numeric). == Design == Wherever possible, Biopython follows the conventions used by the Python programming language to make it easier for users familiar with Python. For example, Seq and SeqRecord objects can be manipulated via slicing, in a manner similar to Python's strings and lists. It is also designed to be functionally similar to other Bio projects, such as BioPerl. It is organized into modular sub-packages, e.g., Bio.Seq, Bio.Align, Bio.PDB, Bio.Entrez each of them useful in a different bioinformatics domain. It used principles, like encapsulation and polymorphism, notably in classes Seq, SeqRecord, and Bio.PDB.Structure. It can also interoperate with other Python tools (Pandas, Matplotlib and SciPy). Biopython can read and write most common file formats for each of its functional areas, and its license is permissive and compatible with most other software licenses, which allows Biopython to be used in a variety of software projects. == Requirements == Biopython is currently supported and tested with the following Python implementations: Python 3 or PyPy3 NumPy == Key features and examples == === Input and output === Biopython can read and write to a number of common formats. When reading files, descriptive information in the file is used to populate the members of Biopython classes, such as SeqRecord. This allows records of one file format to be converted into others. Very large sequence files can exceed a computer's memory resources, so Biopython provides various options for accessing records in large files. They can be loaded entirely into memory in Python data structures, such as lists or dictionaries, providing fast access at the cost of memory usage. Alternatively, the files can be read from disk as needed, with slower performance but lower memory requirements. === Sequences === A core concept in Biopython is the biological sequence, and this is represented by the Seq class. A Biopython Seq object is similar to a Python string in many respects: it supports the Python slice notation, can be concatenated with other sequences and is immutable. This object includes both general string-like and biological sequence-specific methods. It is best to store information about the biological type (DNA, RNA, protein) separately from the sequence, rather than using an explicit alphabet argument. === Sequence annotation === The SeqRecord class describes sequences, along with information such as name, description and features in the form of SeqFeature objects. Each SeqFeature object specifies the type of the feature and its location. Feature types can be ‘gene’, ‘CDS’ (coding sequence), ‘repeat_region’, ‘mobile_element’ or others, and the position of features in the sequence can be exact or approximate. === Accessing online databases === Through the Bio.Entrez module, users of Biopython can download biological data from NCBI databases. Each of the functions provided by the Entrez search engine is available through functions in this module, including searching for and downloading records. === Phylogeny === The Bio.Phylo module provides tools for working with and visualising phylogenetic trees. A variety of file formats are supported for reading and writing, including Newick, NEXUS and phyloXML. Common tree manipulations and traversals are supported via the Tree and Clade objects. Examples include converting and collating tree files, extracting subsets from a tree, changing a tree's root, and analysing branch features such as length or score. Rooted trees can be drawn in ASCII or using matplotlib (see Figure 1), and the Graphviz library can be used to create unrooted layouts (see Figure 2). === Genome diagrams === The GenomeDiagram module provides methods of visualising sequences within Biopython. Sequences can be drawn in a linear or circular form (see Figure 3), and many output formats are supported, including PDF and PNG. Diagrams are created by making tracks and then adding sequence features to those tracks. By looping over a sequence's features and using their attributes to decide if and how they are added to the diagram's tracks, one can exercise much control over the appearance of the final diagram. Cross-links can be drawn between different tracks, allowing one to compare multiple sequences in a single diagram. === Macromolecular structure === The Bio.PDB module can load molecular structures from PDB and mmCIF files, and was added to Biopython in 2003. The Structure object is central to this module, and it organises macromolecular structure in a hierarchical fashion: Structure objects contain Model objects which contain Chain objects which contain Residue objects which contain Atom objects. Disordered residues and atoms get their own classes, DisorderedResidue and DisorderedAtom, that describe their uncertain positions. Using Bio.PDB, one can navigate through individual components of a macromolecular structure file, such as examining each atom in a protein. Common analyses can be carried out, such as measuring distances or angles, comparing residues and calculating residue depth. === Population genetics === The Bio.PopGen module adds support to Biopython for Genepop, a software package for statistical analysis of population genetics. This allows for analyses of Hardy–Weinberg equilibrium, linkage disequilibrium and other features of a population's allele frequencies. This module can also carry out population genetic simulations using coalescent theory with the fastsimcoal2 program. === Wrappers for command line tools === Biopython previously included command-line wrappers for tools such as BLAST, Clustal, EMBOSS, and SAMtools. This option allowed users to run external tool commands from within the code using specialized Biopython classes. However, Bio.Application modules and their wrappers have deprecated and will be removed in future Biopython releases. The main reason for this is the high maintenance burden of updating them with the evolving external tools. The recommended approach is to directly construct and execute command-line tool commands using Python’s built-in subprocess module. This method provides flexibility and removes the dependency on the Biopython wrappers. subprocess is a native Python module useful for running ext
Jensen Huang
Jen-Hsun "Jensen" Huang (Chinese: 黃仁勳; Wade–Giles: Huáng Jén-hsūn; Tâi-lô: N̂g Jîn-hun; born February 17, 1963) is a Taiwanese and American business executive and electrical engineer who is the founder, president, and CEO of Nvidia, the world's most valuable company. As of 2026, Forbes estimates his net worth at over US$200 billion, making him the seventh-wealthiest individual in the world. The son of Taiwanese immigrants, Huang spent his childhood in Taiwan and Thailand before moving to the United States, where he was a student in Kentucky and Oregon. After earning a master's degree from Stanford University, Huang launched Nvidia in 1993 from a Denny's restaurant in San Jose, California, at age 30 and has remained its president and CEO ever since. He led the company out of near-bankruptcy during the 1990s and oversaw its expansion into GPU production, high-performance computing, and artificial intelligence (AI). Under Huang, Nvidia experienced rapid growth during the AI boom, becoming the first company to reach a market capitalization of over $5 trillion in October 2025. In 2021 and 2024, Time magazine included Huang in their list of the most influential people. In 2025, he was named as one of the "Architects of AI" for Time's Person of the Year. == Early life and education == Huang was born in Taipei, Taiwan, on February 17, 1963, and moved to the southern city of Tainan as a child. He is the younger of two sons of Huang Hsing-tai, a chemical engineer at an oil refinery, and Lo Tsai-hsiu, a schoolteacher. They were a middle-class Taiwanese family that relocated often, and were native speakers of Taiwanese Hokkien. Each day, Jensen's mother randomly selected 10 words from the dictionary to teach her sons English. When he was five years old, Huang's family moved to Thailand to support his father's refinery career and remained there for approximately four years. He attended Ruamrudee International School while in Bangkok. In the late 1960s, Hsing-tai traveled from Taiwan to New York City to train under an air conditioning company and, after returning home, resolved to send his sons to the United States. At age nine, Jensen, despite not yet being able to speak English fluently, was sent by his parents to live in the United States. He and his older brother moved in 1973 to live with an uncle in Tacoma, Washington, escaping widespread social unrest in Thailand. Both Huang's aunt and uncle were recent immigrants to Washington state; they accidentally enrolled him and his brother in the Oneida Baptist Institute, a religious reform academy in Kentucky for troubled youth, mistakenly believing it to be a prestigious boarding school. In order to afford the academy's tuition, Jensen's parents sold nearly all their possessions. When he was 10 years old, Huang lived with his older brother in the Oneida boys' dormitory. Each student was expected to work every day, and his brother was assigned to perform manual labor on a nearby tobacco farm. Because he was too young to attend classes at the reform academy, Huang was educated at a separate public school—the Oneida Elementary school in Oneida, Kentucky—arriving as "an undersized Asian immigrant with long hair and heavily accented English" and was frequently bullied and beaten. In Oneida, Huang cleaned toilets every day, learned to play table-tennis, joined the swimming team, and appeared in Sports Illustrated at age 14. He taught his illiterate roommate, a "17-year-old covered in tattoos and knife scars," how to read in exchange for being taught how to bench press. In 2002, Huang said he remembered his life in Kentucky "more vividly than just about any other". Two years after Huang arrived in Oneida, his parents moved to the United States and settled in Beaverton, Oregon, after which the brothers withdrew from school in Kentucky to live back with them. As a teenager, Huang attended Aloha High School in Aloha, Oregon, where he excelled academically. He skipped two grades, graduated at age 16, and became a nationally ranked table-tennis player in addition to being a member of its mathematics, computer, and science clubs. In 1977, the school purchased an Apple II computer. Huang used the machine to play Super Star Trek, a text-based game, and to program in BASIC, creating his own version of Snake. Beginning at age 15, Huang got his first job working the graveyard shift at a local Denny's restaurant as a dishwasher, busboy, and waiter from 1978 to 1983. After high school, he chose to enroll at Oregon State University due to its low in-state tuition. He studied electrical engineering and graduated in 1984 with a bachelor's degree with highest honors. Huang later recalled, "I was the youngest kid in school, in class" and the only student who "looked like a child". Years later, while working as a microchip designer in Silicon Valley, he concurrently pursued graduate night classes at Stanford University, where he earned a master's degree in electrical engineering in 1992. == AMD and LSI Logic == After graduating from college, Huang was a microchip designer in Silicon Valley. He was recruited for positions at Texas Instruments, Advanced Micro Devices (AMD), and LSI Logic, ultimately choosing the California-based AMD due to already being familiar with the company. Huang designed AMD microprocessors while simultaneously attending Stanford and raising his two children. However, when he heard of new chip design processes at LSI Logic, Huang left AMD to assume a role as a technical officer at the LSI Corporation, working under a startup company, Sun Microsystems, where he met engineers Chris Malachowsky and Curtis Priem. LSI was in contract with Sun Microsystems and had introduced Huang to Malachowsky and Priem, who were working on a new graphics accelerator card. While the three produced the card's manufacturing process, the relationship between Malachowsky and Priem became strained as the two disputed the chip's design, leading to infighting; according to Malachowsky, they "broke every tool that LSI Logic had in their standard portfolio". In 1989, Huang, Malachowsky, and Priem finalized the accelerator, which they called the "GX graphics engine". GX was a widespread financial success; the sales of the graphics engine contributed to Sun Microsystem's revenue increasing from $262 million in 1987 to $656 million in 1990, and Huang was promoted to be the director of LSI's CoreWare, a division that manufactured chips for hardware vendors. == Nvidia == === Founding (1993) === When business began to slow for Sun Microsystems after 1990, Huang, along with Priem and Malachowsky, each resigned their jobs to pursue a venture together in making graphics chips for PC games. They initially named their new company "NVision" until Huang suggested that the company be named "Nvidia" based on the Latin word invidia, as Priem wanted competitors to turn "green with envy". They eventually dropped the "i" to honor the NV1 chip that they were then developing. The three met frequently in 1992 at a Denny's roadside diner in East San Jose to formulate a business plan. Huang chose for them to meet at Denny's due to his prior work experience at the restaurant chain and because it was "quieter than home and had cheap coffee". The three founded the company during one meeting at a breakfast booth at the diner. To formally incorporate the company, Huang found a lawyer, James Gaither of Cooley Godward, who demanded the $200 in cash in Huang's pockets to capitalize the company. After that meeting, Huang went back to Priem and Malachowsky to ask each of them for $200 for their respective shares of the company, which meant that Nvidia's initial capital was $600. On April 5, 1993, Huang personally signed Nvidia's original articles of incorporation into effect. Although he left LSI, Huang remained in good standing with the company and was able to secure funding for Nvidia from LSI's CEO, Wilfred Corrigan, who introduced Huang to venture capitalist Don Valentine. An account cited how Huang's presentation pitch went badly. Valentine, the leader of Sequoia Capital, chose to invest in Nvidia through Corrigan's support, as did Sutter Hill Ventures. The funding enabled Nvidia to begin development efforts toward its first chip and to begin paying wages for its employees. By the first day of operation, Huang was made Nvidia's president and CEO. Even though Huang, at age 30, was younger than Priem and Malachowsky, both Priem and Malachowsky believed that he was prepared to be CEO. According to Priem, "we basically deferred to Jensen on day one" and told Huang, "you're in charge of running the company—all the stuff Chris and I don't know how to do". === President and CEO (1993–present) === As of 2024, Huang has been Nvidia's chief executive for over three decades, a tenure described by The Wall Street Journal as "almost unheard of in fast-moving Silicon Valley". He owns 3.6% of Nvidia's stock, which went public in 1999. He earned US$24.6 million as CEO i