Webedia S.A. is a company specializing in online media, a subsidiary of the Fimalac group based in Levallois-Perret, France. Webedia is active in more than twenty countries including France (AlloCiné, Jeuxvideo.com, MGG, Puremédias, Ode, Pureshopping, Volum, Terrafemina, 750g, easyVoyage, l’Automobile Magazine, Le 10 Sport), Brazil (AdoroCinema, Tudo Gostoso, Minhavida), Germany (Filmstarts, Moviepilot, GameStar), Spain and Latin America (Xataka, SensaCine, Raiser Games), Poland (Gry-Online and GetHero) and the United States (Boxoffice Pro). == History == === Early years (2007-2013) === Webedia was created in France in 2007, following the successive launches of the websites Purepeople, Puretrend and Purefans. Webedia bought the comparison shopping website Shopoon in 2008 and renamed it Pureshopping, and the website Ozap (media news) from M6 group in 2011 and renamed it Puremédias. Webedia was acquired by Fimalac in May 2013 and became its Internet media subsidiary. === Growth (2013-2016) === In 2013, Fimalac acquired AlloCiné, the websites Newsring and Youmag, the cooking website 750g and the cultural platform Exponaute. In 2014, Webedia acquired OverBlog, Jeuxvideo.com (through L'Odyssée Interactive and moved to Paris in 2015), Moviepilot (Germany), and Gameo Consulting (owner of Millenium, electronic sports), In December 2014, Webedia announced a license agreement with Ziff Davis to launch sites under the IGN franchise in Brazil and France at the beginning of 2015. The French version of IGN was launched on 2, it targets the general public and casual gamers. In 2015, Webedia acquired Côté Ciné Group (technological solutions for movie theaters and specialized press magazines: BoxOffice Pro in the United States and Côté Ciné in France), 57% of Easyvoyage group (online travel comparators Easyvol and Alibabuy, Mixicom (website JeuxActu and multi-channel network), 50% of the Brazilian network Paramaker, and West World Media (digital marketing company for the film industry). In 2016, Webedia bought Scimob (mobile video game studio), Surprizemi (home-delivered surprise boxes), Eklablog (blogging platform) Oxent (eSports World Convention), and Bang Bang Management (sports PR agency). In addition, an agreement is made with Paris Saint-Germain for Webedia to recruit and manage e-sports players on behalf of Paris Saint-Germain eSports. On November 15, 2016, the LFP announced that it had reached an agreement with beIN Sports and Webedia for the broadcasting of the first edition of the e-League 1. The competition is renewed for two additional seasons on July 26, 2017, the broadcasting agreements are renewed. On December 8, 2016, Webedia joined forces with Chronopost to launch Pourdebon, a home delivery service that connects Internet users and labeled producers (AOC, organic AB, etc.). Webedia has a slight majority (53%) in this new platform. === 2017 === On January 19, 2017, Webedia announced the acquisition of the English company Peach Digital, specializing in web development and digital marketing for movie theaters. In February 2017, Le Figaro announced that Webedia had invested 10 million euros in Illico Fresco, a home delivery service for baskets of recipes. The same month, FDJ and Webedia announced a partnership for the creation of eSports competitions: a professional one (FDJ Masters League) and another one for amateur gamers (FDJ Open Series) starting in March 2017. They are broadcast on Webedia's Web TV. At the end of February 2017, the media group finalized the acquisition of MyPoseo, a SaaS publisher specialized on SEO analytics. On March 8, 2017, Webedia launched LeStream, a Twitch Web TV dedicated to video games, the result of two years of development, in the company of several YouTubers including Cyprien and Squeezie,. On March 29, 2017, Webedia bought the Brazilian web publisher Minha Vida, a website devoted to health, nutrition, beauty and fitness, which attracts 14.3 million unique monthly visitors. Webedia reaches 44 million unique visitors in Brazil, and thus becomes the leading publisher on entertainment themes. In June 2017, the company made its largest international acquisition, with the American agency 3BlackDot, a media and marketing agency focused on videogamers. The agency, based in Los Angeles, manages 36 YouTubers followed by millions of subscribers on their channels which total 700 million videos viewed per month. In July 2017, Webedia bought IDZ, an audiovisual production company, and thus strengthened its production activities and its leadership on the YouTube channel networks in France. That year, Webedia was the first French media group to use the measurement of their global audiences by Comscore. It represents deduplicated coverage on desktops, laptops, smartphones and tablets, and includes audiences for websites, mobile applications and videos. This new measure allows Webedia to establish a deduplicated global audience of 177 million unique visitors in April 2017. In October 2017, Webedia announced its intention to launch a TV channel dedicated to electronic sports, called ES1. The channel was officially launched on January 10, 2018, on Orange TV and on February 6, 2018, on Free and Bouygues Telecom. In November 2017, Webedia, with the support of CDC International Capital, entered into exclusive negotiations with the Saudi company Uturn Entertainment, specializing in online entertainment, particularly on YouTube, and the production of digital content for the region's youth, with a view to merging it with Diwanee, a Webedia subsidiary in the Middle East, for an amount close to $100 million. In December 2017, Webedia acquired a majority stake in the United States–based company called Creators Media, which brings together social and video production platforms specializing in popular culture and entertainment. That same month, Webedia joined forces with Elephant, Emmanuel Chain's audiovisual production company, to create a new content production label aimed at Millennials. === 2018-2019 === In January 2018, Webedia launched a sports marketing agency: Only Sports & Passions. That same month, Illico Fresco, specialist in the delivery of kit meals belonging to Webedia, joined forces with Weight Watchers, the world leader in slimming products. In April 2018, Webedia published new audience figures in partnership with Comscore, 188 million unique monthly visitors in December 2017, an increase of 6.2% compared to the previous measure dating from April 2017. The same month, Webedia unveils its ambitions concerning content production, as a partnership with the video game studio Focus Home Interactive is signed with a title "Fear the Wolves" already planned for 2018, co-production projects of films, cartoons or series are announced. In July 2018, Webedia bought the American authors company Full Fathom Five, a company that helps authors produce books, TV series, films and video games. In October 2018, Webedia announced that it was focusing on both esports clubs PSG Esports and LeStream Esport. The first one being geared towards international competitions and the second devoted mainly to the French esports scene. The "Millenium" brand is thus refocusing around its media activities and esports merchandising products, and the "Millenium esport club" being gradually closed. The same month, the company announced the acquisition of Weblogs, a Spanish-speaking website publisher, thereby strengthening its activity in Spain and Latin America. On October 22, 2018, Webedia announced the merger of BoxOffice magazine with Film Journal International. On November 13, 2018, Groupe SEB announced the acquisition from Webedia of 750g International, the international branch of the French recipe site 750g (the original French website 750g.com being retained by Webedia). The group is thus separating from Gourmandize (United States and United Kingdom), HeimGourmet (Germany), Rebañando (Spain), Receitas Sem Fronteiras (Brazil / Portugal) and Tribù Golosa (Italy). The same month, Webedia joined forces with Riot Games to launch the French League of League of Legends (LFL), the first French professional league on the League of Legends game, which will bring together the 8 best teams on the French scene. In March 2019, Webedia bought 51% of the audiovisual production company Elephant. The new set will weigh 500 million euros, a quarter of which will be made outside France. The same month, Webedia purchased a majority stake in the company Partoo, which publishes a SaaS platform specializing in local marketing for brands and merchants. On March 14, 2019, a new measurement of the international audience of Webedia sites was produced by Comscore, posting 250 million unique visitors in December 2018, up 9.2% compared to December 2017. In June 2019, the group joined forces with Michel Cymes, a famous doctor and French TV host by taking a majority stake in his company Club Santé Débat, in order to develop a health platform around the Dr. Good! Brand. 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Feng Office Community Edition
Feng Office Community Edition (formerly OpenGoo) is an open-source collaboration platform developed and supported by Feng Office and the OpenGoo community. It is a fully featured online office suite with a similar set of features as other online office suites, like Google Workspace, Microsoft 365, Zimbra, LibreOffice Online and Zoho Office Suite. The application can be downloaded and installed on a server. Feng Office could also be categorized as collaborative software and as personal information manager software. == Features == Feng Office Community Edition main features include project management, document management, contact management, e-mail and time management. Text documents and presentations can be created and edited online. Files can be uploaded, organized and shared, independent of file formats. Organization of the information in Feng Office Community Edition is done using workspaces and tags. The application presents the information stored using different interfaces such as lists, dashboards and calendar views. == Licensing == Feng Office Community Edition is distributed under the GNU Affero General Public License, version 3 only. == Technology used == Feng Office uses PHP, JavaScript, AJAX (ExtJS) and MySQL technology. Several open source projects served as a basis for development. ActiveCollab's last open sourced release was used as the initial code base. It includes CKEditor for online document editing. == System requirements == The server could run on any operating system. The system needs the following packages: Apache HTTP Server 2.0+ PHP 5.0+ MySQL 4.1+ (InnoDB support recommended) On the client side, the user is only required to use a modern Web browser. == History == OpenGoo started as a degree project at the faculty of Engineering of the University of the Republic, Uruguay. The project was presented and championed by Software Engineer Conrado Viña. Software Engineers Marcos Saiz and Ignacio de Soto developed the first prototype as their thesis. Professors Eduardo Fernández and Tomas Laurenzo served as tutors. Conrado, Ignacio and Marcos founded the OpenGoo community and remain active members and core developers. The thesis was approved with the highest score. In 2008, Viña joined the Uruguayan software development company Moove It. Currently there is a second project for OpenGoo at the same university being developed by students Fernando Rodríguez, Ignacio Vázquez and Juan Pedro del Campo. Their project aims to build an open source Web-based spreadsheet. In December 2009 the OpenGoo name was changed to Feng Office Community Edition.
Douglas Parkhill
Douglas F. Parkhill is a Canadian technologist and former research minister, best known for his pioneering work on what is now called cloud computing, and his work on Canada's Telidon videotex project. He started working at the Canadian ministry of Communications (now part of the Department of Trade and Industry) in 1969, having previously worked at the Mitre Corporation. He was responsible for many activities in communications satellites, computer communications, command and control systems and telecommunications. He was winner of the Treasury Board of Canada Secretariat's Outstanding Achievement award in 1982, the Conestoga shield for services to government and industry in computer communications research and development, the Touche Ross award for Telidon development. He was an author of several publications including the 1966 book, The Challenge of the Computer Utility. In the book, Parkhill thoroughly explored many of the modern-day characteristics of cloud computing (elastic provisioning through a utility service) as well as the comparison to the electricity industry and the use of public, private, government and community forms. The book won the McKinsey Foundation award for distinguished contributions to management literature. He worked with Dave Godfrey, the Canadian writer and novelist on a later book Gutenberg two about the social and political meaning of computer technology. He was in charge of research at the Federal Department of Communications at the time when the department was funding development of the Telidon videotext system, was heavily involved in promoting the system, and had overall control of the program. In a radio broadcast in 1980, he outlined some of the potential of the system, from financial information, to theatre reservations, with the ability to pay and print out tickets from the system. He later documented the history of the Telidon project, and the history of videotext in general. == Publications == The Challenge of the Computer Utility, Addison-Wesley, 1966, ISBN 0-201-05720-4 edited with Dave Godfrey, Gutenberg Two: The New Electronics and Social Change, Press Porcepic, 1979, ISBN 0-88878-191-1 The Beginning of a Beginning. Ottawa; Department of Communications, 1987. A history of the Telidon project.
Circle Hough Transform
The circle Hough Transform (CHT) is a basic feature extraction technique used in digital image processing for detecting circles in imperfect images. The circle candidates are produced by “voting” in the Hough parameter space and then selecting local maxima in an accumulator matrix. It is a specialization of the Hough transform. == Theory == In a two-dimensional space, a circle can be described by: ( x − a ) 2 + ( y − b ) 2 = r 2 ( 1 ) {\displaystyle \left(x-a\right)^{2}+\left(y-b\right)^{2}=r^{2}\ \ \ \ \ (1)} where (a,b) is the center of the circle, and r is the radius. If a 2D point (x,y) is fixed, then the parameters can be found according to (1). The parameter space would be three dimensional, (a, b, r). And all the parameters that satisfy (x, y) would lie on the surface of an inverted right-angled cone whose apex is at (x, y, 0). In the 3D space, the circle parameters can be identified by the intersection of many conic surfaces that are defined by points on the 2D circle. This process can be divided into two stages. The first stage is fixing radius then find the optimal center of circles in a 2D parameter space. The second stage is to find the optimal radius in a one dimensional parameter space. === Find parameters with known radius R === If the radius is fixed, then the parameter space would be reduced to 2D (the position of the circle center). For each point (x, y) on the original circle, it can define a circle centered at (x, y) with radius R according to (1). The intersection point of all such circles in the parameter space would be corresponding to the center point of the original circle. Consider 4 points on a circle in the original image (left). The circle Hough transform is shown in the right. Note that the radius is assumed to be known. For each (x,y) of the four points (white points) in the original image, it can define a circle in the Hough parameter space centered at (x, y) with radius r. An accumulator matrix is used for tracking the intersection point. In the parameter space, the voting number of those points that have a newly defined circle passing through them would be increased by one for every circle. Then the local maxima point (the red point in the center in the right figure) can be found. The position (a, b) of the maxima would be the center of the original circle. === Multiple circles with known radius R === Multiple circles with same radius can be found with the same technique. Note that, in the accumulator matrix (right fig), there would be at least 3 local maxima points. === Accumulator matrix and voting === In practice, an accumulator matrix is introduced to find the intersection point in the parameter space. First, we need to divide the parameter space into “buckets” using a grid and produce an accumulator matrix according to the grid. The element in the accumulator matrix denotes the number of “circles” in the parameter space that are passing through the corresponding grid cell in the parameter space. The number is also called “voting number”. Initially, every element in the matrix is zeros. Then for each “edge” point in the original space, we can formulate a circle in the parameter space and increase the voting number of the grid cell which the circle passes through. This process is called “voting”. After voting, we can find local maxima in the accumulator matrix. The positions of the local maxima are corresponding to the circle centers in the original space. === Find circle parameter with unknown radius === Since the parameter space is 3D, the accumulator matrix would be 3D, too. We can iterate through possible radii; for each radius, we use the previous technique. Finally, find the local maxima in the 3D accumulator matrix. Accumulator array should be A[x,y,r] in the 3D space. Voting should be for each pixels, radius and theta A[x,y,r] += 1 The algorithm : For each A[a,b,r] = 0; Process the filtering algorithm on image Gaussian Blurring, convert the image to grayscale ( grayScaling), make Canny operator, The Canny operator gives the edges on image. Vote on all possible circles in accumulator. The local maximum voted circles of Accumulator A gives the circle Hough space. The maximum voted circle of Accumulator gives the circle. The Incrementing for Best Candidate : For each A[a,b,r] = 0; // fill with zeroes initially, instantiate 3D matrix For each cell(x,y) For each theta t = 0 to 360 // the possible theta 0 to 360 b = y – r sin(t PI / 180); //polar coordinate for center (convert to radians) a = x – r cos(t PI / 180); //polar coordinate for center (convert to radians) A[a,b,r] +=1; //voting end end == Examples == === Find circles in a shoe-print === The original picture (right) is first turned into a binary image (left) using a threshold and Gaussian filter. Then edges (mid) are found from it using canny edge detection. After this, all the edge points are used by the Circle Hough Transform to find underlying circle structure. == Limitations == Since the parameter space of the CHT is three dimensional, it may require lots of storage and computation. Choosing a bigger grid size can ameliorate this problem. However, choosing an appropriate grid size is difficult. Since too coarse a grid can lead to large values of the vote being obtained falsely because many quite different structures correspond to a single bucket. Too fine a grid can lead to structures not being found because votes resulting from tokens that are not exactly aligned end up in different buckets, and no bucket has a large vote. Also, the CHT is not very robust to noise. == Extensions == === Adaptive Hough Transform === J. Illingworth and J. Kittler introduced this method for implementing Hough Transform efficiently. The AHT uses a small accumulator array and the idea of a flexible iterative "coarse to fine" accumulation and search strategy to identify significant peaks in the Hough parameter spaces. This method is substantially superior to the standard Hough Transform implementation in both storage and computational requirements. == Application == === People Counting === Since the head would be similar to a circle in an image, CHT can be used for detecting heads in a picture, so as to count the number of persons in the image. === Brain Aneurysm Detection === Modified Hough Circle Transform (MHCT) is used on the image extracted from Digital Subtraction Angiogram (DSA) to detect and classify aneurysms type. == Implementation code == Circle Detection via Standard Hough Transform, by Amin Sarafraz, Mathworks (File Exchange) Hough Circle Transform, OpenCV-Python Tutorials (archived version on archive.org)
Content Disarm and Reconstruction
Content Disarm and Reconstruction (CDR) is a computer security technology for removing potentially malicious code from files. Unlike malware analysis, CDR technology does not determine or detect malware's functionality but removes all file components that are not approved within the system's definitions and policies. It is used to prevent cyber security threats from entering a corporate network perimeter. Channels that CDR can be used to protect include email and website traffic. Advanced solutions can also provide similar protection on computer endpoints, or cloud email and file sharing services. There are three levels of CDR; 1) flattening and converting the original file to a PDF, 2) stripping active content while keeping the original file type, and 3) eliminating all file-borne risk while maintaining file type, integrity and active content. Beyond these three levels, there are also more advanced forms of CDR that is able to perform "soft conversion" and "hard conversion", based on the user's preference in balancing usability and security. == Applications == CDR works by processing all incoming files of an enterprise network, deconstructing them, and removing the elements that do not match the file type's standards or set policies. CDR technology then rebuilds the files into clean versions that can be sent on to end users as intended. Because CDR removes all potentially malicious code, it can be effective against zero-day vulnerabilities that rely on being an unknown threat that other security technologies would need to patch against to maintain protection. CDR can be used to prevent cyber threats from variety of sources: Email Data Diodes Web Browsers Endpoints File Servers FTP Cloud email or webmail programs SMB/CIFS Removable media scanning (CDR Kiosk) CDR can be applied to a variety of file formats including: Images Office documents PDF Audio/video file formats Archives HTML == Open source implementations == DocBleach ExeFilter
IDMS
The Integrated Database Management System (IDMS) is a network model (CODASYL) database management system for mainframes. It was first developed at BFGoodrich and later marketed by Cullinane Database Systems (renamed Cullinet in 1983). Since 1989 the product has been owned by Computer Associates (now CA Technologies), who renamed it Advantage CA-IDMS and later simply to CA IDMS. In 2018 Broadcom acquired CA Technologies, renaming it back to IDMS. == History == The roots of IDMS go back to the pioneering database management system called Integrated Data Store (IDS), developed at General Electric by a team led by Charles Bachman and first released in 1964. In the early 1960s IDS was taken from its original form, by the computer group of the BFGoodrich Chemical Division, and re-written in a language called Intermediate System Language (ISL). ISL was designed as a portable system programming language able to produce code for a variety of target machines. Since ISL was actually written in ISL, it was able to be ported to other machine architectures with relative ease, and then to produce code that would execute on them. The Chemical Division computer group had given some thought to selling copies of IDMS to other companies, but was told by management that they were not in the software products business. Eventually, a deal was struck with John Cullinane to buy the rights and market the product. Because Cullinane was required to remit royalties back to B.F. Goodrich, all add-on products were listed and billed as separate products – even if they were mandatory for the core IDMS product to work. This sometimes confused customers. The original platforms were the GE 235 computer and GE DATANET-30 message switching computer: later the product was ported to IBM mainframes and to DEC and ICL hardware. The IBM-ported version runs on IBM mainframe systems (System/360, System/370, System/390, zSeries, System z9). In the mid-1980s, it was claimed that some 2,500 IDMS licenses had been sold. Users included the Strategic Air Command, Ford of Canada, Ford of Europe, Jaguar Cars, Clarks Shoes UK, Axa/PPP, MAPFRE, Royal Insurance, Tesco, Manulife, Hudson's Bay Company, Cleveland Clinic, Bank of Canada, General Electric, Aetna and BT in the UK. A version for use on the Digital Equipment Corporation PDP-11 series of computers was sold to DEC and was marketed as DBMS-11. In 1976 the source code was licensed to ICL, who ported the software to run on their 2900 series mainframes, and subsequently also on the older 1900 range. ICL continued development of the software independently of Cullinane, selling the original ported product under the name ICL 2900 IDMS and an enhanced version as IDMSX. In this form it was used by many large UK users, an example being the Pay-As-You-Earn system operated by Inland Revenue. Many of these IDMSX systems for UK Government were still running in 2013. In the early to mid-1980s, relational database management systems started to become more popular, encouraged by increasing hardware power and the move to minicomputers and client–server architecture. Relational databases offered improved development productivity over CODASYL systems, and the traditional objections based on poor performance were slowly diminishing. Cullinet attempted to continue competing against IBM's DB2 and other relational databases by developing a relational front-end and a range of productivity tools. These included Automatic System Facility (ASF), which made use of a pre-existing IDMS feature called LRF (Logical Record Facility). ASF was a fill-in-the-blanks database generator that would also develop a mini-application to maintain the tables. It is difficult to judge whether such features may have been successful in extending the selling life of the product, but they made little impact in the long term. Those users who stayed with IDMS were primarily interested in its high performance, not in its relational capabilities. It was widely recognized (helped by a high-profile campaign by E. F. Codd, the father of the relational model) that there was a significant difference between a relational database and a network database with a relational veneer. In 1989 Computer Associates continued after Cullinet acquisition with the development and released Release 12.0 with full SQL in 1992–93. CA Technologies continued to market and support the CA IDMS and enhanced IDMS in subsequent releases by TCP/IP support, two phase commit support, XML publishing, zIIP specialty processor support, Web-enabled access in combination with CA IDMS Server, SQL Option and GUI database administration via CA IDMS Visual DBA tool. CA-IDMS systems are today still running businesses worldwide. Many customers have opted to web-enable their applications via the CA-IDMS SQL Option which is part of CA Technologies' Dual Database Strategy. == Integrated Data Dictionary == One of the sophisticated features of IDMS was its built-in Integrated data dictionary (IDD). The IDD was primarily developed to maintain database definitions. It was itself an IDMS database. DBAs (database administrators) and other users interfaced with the IDD using a language called Data Dictionary Definition Language (DDDL). IDD was also used to store definitions and code for other products in the IDMS family such as ADS/Online and IDMS-DC. IDD's power was that it was extensible and could be used to create definitions of just about anything. Some companies used it to develop in-house documentation. == Overview == === Logical Data Model === The data model offered to users is the CODASYL network model. The main structuring concepts in this model are records and sets. Records essentially follow the COBOL pattern, consisting of fields of different types: this allows complex internal structure such as repeating items and repeating groups. The most distinctive structuring concept in the Codasyl model is the set. Not to be confused with a mathematical set, a Codasyl set represents a one-to-many relationship between records: one owner, many members. The fact that a record can be a member in many different sets is the key factor that distinguishes the network model from the earlier hierarchical model. As with records, each set belongs to a named set type (different set types model different logical relationships). Sets are in fact ordered, and the sequence of records in a set can be used to convey information. A record can participate as an owner and member of any number of sets. Records have identity, the identity being represented by a value known as a database key. In IDMS, as in most other Codasyl implementations, the database key is directly related to the physical address of the record on disk. Database keys are also used as pointers to implement sets in the form of linked lists and trees. This close correspondence between the logical model and the physical implementation (which is not a strictly necessary part of the Codasyl model, but was a characteristic of all successful implementations) is responsible for the efficiency of database retrieval, but also makes operations such as database loading and restructuring rather expensive. Records can be accessed directly by database key, by following set relationships, or by direct access using key values. Initially the only direct access was through hashing, a mechanism known in the Codasyl model as CALC access. In IDMS, CALC access is implemented through an internal set, linking all records that share the same hash value to an owner record that occupies the first few bytes of every disk page. In subsequent years, some versions of IDMS added the ability to access records using BTree-like indexes. === Storage === IDMS organizes its databases as a series of files. These files are mapped and pre-formatted into so-called areas. The areas are subdivided into pages which correspond to physical blocks on the disk. The database records are stored within these blocks. The DBA allocates a fixed number of pages in a file for each area. The DBA then defines which records are to be stored in each area, and details of how they are to be stored. IDMS intersperses special space-allocation pages throughout the database. These pages are used to keep track of the free space available in each page in the database. To reduce I/O requirements, the free space is only tracked for all pages when the free space for the area falls below 30%. Four methods are available for storing records in an IDMS database: Direct, Sequential, CALC, and VIA. The Fujitsu/ICL IDMSX version extends this with two more methods, Page Direct, and Random. In direct mode the target database key is specified by the user and is stored as close as possible to that DB key, with the actual DB key on which the record is stored being returned to the application program. Sequential placement (not to be confused with indexed sequential), simply places each new record at the end of the area. This option is rarely used. CALC uses a hashing algo
GeneTalk
GeneTalk is a web-based platform, tool, and database for filtering, reduction and prioritization of human sequence variants from next-generation sequencing (NGS) data. GeneTalk allows editing annotation about sequence variants and build up a crowd sourced database with clinically relevant information for diagnostics of genetic disorders. GeneTalk allows searching for information about specific sequence variants and connects to experts on variants that are potentially disease-relevant. == Application to diagnostics == Users can upload NGS data in Variant Call Format (VCF) onto the GeneTalk server into their accounts. All entries of the file are preprocessed and shown in the integrated VCF viewer. Filtering tools are set by the user to reduce the number of clinically non-relevant variants. After filtering and prioritization users can interpret relevant variants by retrieving information (annotations) about variants from the GeneTalk database. The communication platform allow users to contact experts about specific variants, genes, or genetic disorders, to exchange knowledge and expertise. === Analysis procedure === Steps required to analyze VCF files Upload VCF file Edit pedigree and phenotype information for segregation filtering Filter VCF file by editing the filtering options View results and annotations Add annotations === Filtering tools === The following filtering options may be used to reduce the non-relevant sequence variants in VCF files. Functional – filter out variants that have effects on protein level Linkage – filter out variants that are on specified chromosomes Gene panel – filter variants by genes or gene panels, subscribe to publicly available gene panels or create own ones Frequency – show only variants with a genotype frequency lower than specified Inheritance – filter out variants by presumed mode of inheritance Annotation – show only variants with a score for medical relevance and scientific evidence == Communication platform and expert network == Users can share VCF files with colleagues and coworkers. The integrated mailing systems allows users to contact experts easily. Users can create annotations and comments and rate annotations regarding medical relevance and scientific evidence, that is helpful for the community of users for diagnosis of genetic disorders. Registered users provide information about their field of knowledge in their profile and can be contacted by other users. == Potential applications == Developing diagnostics Genetic analysis Capturing data generated by community Communication and exchange of knowledge and expertise