GeneTalk is a web-based platform, tool, and database for filtering, reduction and prioritization of human sequence variants from next-generation sequencing (NGS) data. GeneTalk allows editing annotation about sequence variants and build up a crowd sourced database with clinically relevant information for diagnostics of genetic disorders. GeneTalk allows searching for information about specific sequence variants and connects to experts on variants that are potentially disease-relevant. == Application to diagnostics == Users can upload NGS data in Variant Call Format (VCF) onto the GeneTalk server into their accounts. All entries of the file are preprocessed and shown in the integrated VCF viewer. Filtering tools are set by the user to reduce the number of clinically non-relevant variants. After filtering and prioritization users can interpret relevant variants by retrieving information (annotations) about variants from the GeneTalk database. The communication platform allow users to contact experts about specific variants, genes, or genetic disorders, to exchange knowledge and expertise. === Analysis procedure === Steps required to analyze VCF files Upload VCF file Edit pedigree and phenotype information for segregation filtering Filter VCF file by editing the filtering options View results and annotations Add annotations === Filtering tools === The following filtering options may be used to reduce the non-relevant sequence variants in VCF files. Functional – filter out variants that have effects on protein level Linkage – filter out variants that are on specified chromosomes Gene panel – filter variants by genes or gene panels, subscribe to publicly available gene panels or create own ones Frequency – show only variants with a genotype frequency lower than specified Inheritance – filter out variants by presumed mode of inheritance Annotation – show only variants with a score for medical relevance and scientific evidence == Communication platform and expert network == Users can share VCF files with colleagues and coworkers. The integrated mailing systems allows users to contact experts easily. Users can create annotations and comments and rate annotations regarding medical relevance and scientific evidence, that is helpful for the community of users for diagnosis of genetic disorders. Registered users provide information about their field of knowledge in their profile and can be contacted by other users. == Potential applications == Developing diagnostics Genetic analysis Capturing data generated by community Communication and exchange of knowledge and expertise
Artisse AI
Artisse AI is a Hong Kong-based technology company founded by William Wu. The company developed a mobile photography application using generative artificial intelligence to transform selfies into high-quality, personalized images. The app allows users to visualize themselves in various scenarios, outfits, and hairstyles, and they can adjust lighting and ambiance to match their preferences. The app launched in 2023 across multiple markets, including the United States, United Kingdom, Japan, South Korea, Canada, and Australia. By January 2024, users had generated over 5 million images. That same month, the company secured $6.7 million in seed funding to support product development and marketing. == History == Artisse was originally founded in South Korea in 2022 by William Wu. The early concept was connected to a virtual idol initiative developed in collaboration with a K-pop agency, intended to support Wu's blockchain gaming business. The project later evolved into a standalone AI photography application. The current version of the Artisse app was developed following the company's relocation to Hong Kong in 2022. In January 2024, Artisse secured $6.7 million in seed funding, led by The London Fund. The investment was aimed at supporting product development, marketing, and user acquisition. Artisse uses an AI algorithm to create hyperrealistic images from uploaded photos. The app generates personalized images by combining generative AI technology, a global pool of licensed talent, and finished art services. The app works with individual users and businesses, offering professional-grade photos and advertisement images. According to the British newspaper Evening Standard the company has developed the world's first and most advanced AI photographer. It captures 15-30 photos of the user and generates 2D images, placing them in various outfits and locations worldwide. === Catheron Gaming === Artisse AI originated from Catheon Gaming, a blockchain gaming and entertainment company founded in 2021 by William Wu. Catheon Gaming published more than 30 Web3 titles in its first year, developed a blockchain game distribution platform, and offered advisory services to external developers. In 2022, HSBC and KPMG listed Catheon Gaming among the "Top 10 Emerging Giants" in the Asia–Pacific region, selected from a pool of more than 6,000 startups. In June 2023, Catheon Gaming was rebranded as Artisse Interactive, creating two divisions: Artisse Gaming, which continued blockchain and Web3 game development, and Artisse AI, which focused on generative photography technology. == Technology == Artisse uses a proprietary generative AI model combined with open-source imaging frameworks and diffusion models. Users are prompted to upload between 15 and 30 personal images, allowing the AI to train a personalized model in 30 to 40 minutes. After training, the app generates new images based on either textual or visual prompts, with options to adjust elements such as clothing, hairstyles, lighting, and backgrounds. To enhance realism, the app integrates augmented reality features and image refinement tools. The company has introduced features to address representation issues related to body shape and skin tone, although concerns persist about the ethical implications of altering personal traits. == Products == === Artisse mobile app === Available on iOS and Android platforms in 35 languages. Users initially receive 25 free images, after which the app adopts a subscription pricing model ranging from approximately $6 to $30 per month. By early 2024, the app reported around 4,000 paying subscribers out of more than 200,000 downloads. === Business and enterprise services === Artisse provides B2B solutions for creating marketing imagery and partners with agencies like Iconic Management to enable cost-effective virtual photoshoots. Additional features in development include virtual try-on capabilities and augmented reality integration for fashion retail. == Reception == Media coverage has noted the app's photorealistic image outputs with some sources highlighting its ease of use. However, concerns have been raised regarding image authenticity, algorithmic biases, and the potential impact on professional photography and modeling. Artisse has been widely covered by media outlets including TechCrunch, PetaPixel, Forbes Australia, and The Evening Standard. These publications discussed the app's integration of generative AI technology within the consumer photography space, its growing market influence, and its rapid adoption by users worldwide.
Synaptic weight
In neuroscience and computer science, synaptic weight refers to the strength or amplitude of a connection between two nodes, corresponding in biology to the amount of influence the firing of one neuron has on another. The term is typically used in artificial and biological neural network research. == Computation == In a computational neural network, a vector or set of inputs x {\displaystyle {\textbf {x}}} and outputs y {\displaystyle {\textbf {y}}} , or pre- and post-synaptic neurons respectively, are interconnected with synaptic weights represented by the matrix w {\displaystyle w} , where for a linear neuron y j = ∑ i w i j x i or y = w x {\displaystyle y_{j}=\sum _{i}w_{ij}x_{i}~~{\textrm {or}}~~{\textbf {y}}=w{\textbf {x}}} . where the rows of the synaptic matrix represent the vector of synaptic weights for the output indexed by j {\displaystyle j} . The synaptic weight is changed by using a learning rule, the most basic of which is Hebb's rule, which is usually stated in biological terms as Neurons that fire together, wire together. Computationally, this means that if a large signal from one of the input neurons results in a large signal from one of the output neurons, then the synaptic weight between those two neurons will increase. The rule is unstable, however, and is typically modified using such variations as Oja's rule, radial basis functions or the backpropagation algorithm. == Biology == For biological networks, the effect of synaptic weights is not as simple as for linear neurons or Hebbian learning. However, biophysical models such as BCM theory have seen some success in mathematically describing these networks. In the mammalian central nervous system, signal transmission is carried out by interconnected networks of nerve cells, or neurons. For the basic pyramidal neuron, the input signal is carried by the axon, which releases neurotransmitter chemicals into the synapse which is picked up by the dendrites of the next neuron, which can then generate an action potential which is analogous to the output signal in the computational case. The synaptic weight in this process is determined by several variable factors: How well the input signal propagates through the axon (see myelination), The amount of neurotransmitter released into the synapse and the amount that can be absorbed in the following cell (determined by the number of AMPA and NMDA receptors on the cell membrane and the amount of intracellular calcium and other ions), The number of such connections made by the axon to the dendrites, How well the signal propagates and integrates in the postsynaptic cell. The changes in synaptic weight that occur is known as synaptic plasticity, and the process behind long-term changes (long-term potentiation and depression) is still poorly understood. Hebb's original learning rule was originally applied to biological systems, but has had to undergo many modifications as a number of theoretical and experimental problems came to light.
Hinge loss
In machine learning, the hinge loss is a loss function used for training classifiers. The hinge loss is used for "maximum-margin" classification, most notably for support vector machines (SVMs). For an intended output t = ±1 and a classifier score y, the hinge loss of the prediction y is defined as ℓ ( y ) = max ( 0 , 1 − t ⋅ y ) {\displaystyle \ell (y)=\max(0,1-t\cdot y)} Note that y {\displaystyle y} should be the "raw" output of the classifier's decision function, not the predicted class label. For instance, in linear SVMs, y = w ⋅ x + b {\displaystyle y=\mathbf {w} \cdot \mathbf {x} +b} , where ( w , b ) {\displaystyle (\mathbf {w} ,b)} are the parameters of the hyperplane and x {\displaystyle \mathbf {x} } is the input variable(s). When t and y have the same sign (meaning y predicts the right class) and | y | ≥ 1 {\displaystyle |y|\geq 1} , the hinge loss ℓ ( y ) = 0 {\displaystyle \ell (y)=0} . When they have opposite signs, ℓ ( y ) {\displaystyle \ell (y)} increases linearly with y, and similarly if | y | < 1 {\displaystyle |y|<1} , even if it has the same sign (correct prediction, but not by enough margin). The Hinge loss is not a proper scoring rule. == Extensions == While binary SVMs are commonly extended to multiclass classification in a one-vs.-all or one-vs.-one fashion, it is also possible to extend the hinge loss itself for such an end. Several different variations of multiclass hinge loss have been proposed. For example, Crammer and Singer defined it for a linear classifier as ℓ ( y ) = max ( 0 , 1 + max y ≠ t w y x − w t x ) {\displaystyle \ell (y)=\max(0,1+\max _{y\neq t}\mathbf {w} _{y}\mathbf {x} -\mathbf {w} _{t}\mathbf {x} )} , where t {\displaystyle t} is the target label, w t {\displaystyle \mathbf {w} _{t}} and w y {\displaystyle \mathbf {w} _{y}} are the model parameters. Weston and Watkins provided a similar definition, but with a sum rather than a max: ℓ ( y ) = ∑ y ≠ t max ( 0 , 1 + w y x − w t x ) {\displaystyle \ell (y)=\sum _{y\neq t}\max(0,1+\mathbf {w} _{y}\mathbf {x} -\mathbf {w} _{t}\mathbf {x} )} . In structured prediction, the hinge loss can be further extended to structured output spaces. Structured SVMs with margin rescaling use the following variant, where w denotes the SVM's parameters, y the SVM's predictions, φ the joint feature function, and Δ the Hamming loss: ℓ ( y ) = max ( 0 , Δ ( y , t ) + ⟨ w , ϕ ( x , y ) ⟩ − ⟨ w , ϕ ( x , t ) ⟩ ) = max ( 0 , max y ∈ Y ( Δ ( y , t ) + ⟨ w , ϕ ( x , y ) ⟩ ) − ⟨ w , ϕ ( x , t ) ⟩ ) {\displaystyle {\begin{aligned}\ell (\mathbf {y} )&=\max(0,\Delta (\mathbf {y} ,\mathbf {t} )+\langle \mathbf {w} ,\phi (\mathbf {x} ,\mathbf {y} )\rangle -\langle \mathbf {w} ,\phi (\mathbf {x} ,\mathbf {t} )\rangle )\\&=\max(0,\max _{y\in {\mathcal {Y}}}\left(\Delta (\mathbf {y} ,\mathbf {t} )+\langle \mathbf {w} ,\phi (\mathbf {x} ,\mathbf {y} )\rangle \right)-\langle \mathbf {w} ,\phi (\mathbf {x} ,\mathbf {t} )\rangle )\end{aligned}}} . == Optimization == The hinge loss is a convex function, so many of the usual convex optimizers used in machine learning can work with it. It is not differentiable, but has a subgradient with respect to model parameters w of a linear SVM with score function y = w ⋅ x {\displaystyle y=\mathbf {w} \cdot \mathbf {x} } that is given by ∂ ℓ ∂ w i = { − t ⋅ x i if t ⋅ y < 1 , 0 otherwise . {\displaystyle {\frac {\partial \ell }{\partial w_{i}}}={\begin{cases}-t\cdot x_{i}&{\text{if }}t\cdot y<1,\\0&{\text{otherwise}}.\end{cases}}} However, since the derivative of the hinge loss at t y = 1 {\displaystyle ty=1} is undefined, smoothed versions may be preferred for optimization, such as Rennie and Srebro's ℓ ( y ) = { 1 2 − t y if t y ≤ 0 , 1 2 ( 1 − t y ) 2 if 0 < t y < 1 , 0 if 1 ≤ t y {\displaystyle \ell (y)={\begin{cases}{\frac {1}{2}}-ty&{\text{if}}~~ty\leq 0,\\{\frac {1}{2}}(1-ty)^{2}&{\text{if}}~~0 The Ni1000 is an artificial neural network chip developed by Nestor Corporation and Intel, developed in the 1990s. It is Intel's second-generation neural network chip, but the first all-digital chip. The chip is aimed at image analysis applications– containing more than 3 million transistors – and can analyze 40,000 patterns per second. Prototypes running Nestor's OCR software in 1994 were capable of recognizing around 100 handwritten characters per second. The development was funded with money from DARPA and Office of Naval Research. MegaHAL is a computer conversation simulator, or "chatterbot", created by Jason Hutchens. == Background == In 1996, Jason Hutchens entered the Loebner Prize Contest with HeX, a chatterbot based on ELIZA. HeX won the competition that year and took the $2000 prize for having the highest overall score. In 1998, Hutchens again entered the Loebner Prize Contest with his new program, MegaHAL. MegaHAL made its debut in the 1998 Loebner Prize Contest. Like many chatterbots, the intent is for MegaHAL to appear as a human fluent in a natural language. As a user types sentences into MegaHAL, MegaHAL will respond with sentences that are sometimes coherent and at other times complete gibberish. MegaHAL learns as the conversation progresses, remembering new words and sentence structures. It will even learn new ways to substitute words or phrases for other words or phrases. Many would consider conversation simulators like MegaHAL to be a primitive form of artificial intelligence. However, MegaHAL doesn't understand the conversation or even the sentence structure. It generates its conversation based on sequential and mathematical relationships. In the world of conversation simulators, MegaHAL is based on relatively old technology and could be considered primitive. However, its popularity has grown due to its humorous nature; it has been known to respond with twisted or nonsensical statements that are often amusing. == Theory of Operation == MegaHal is based at least in part on a so-called "hidden Markov Model", so that the first thing that Megahal does when it "trains" on a script or text is to build a database of text fragments encompassing every possible subset of perhaps 4, 5, or even 6 consecutive words, so that for example - if MegaHal trains on the Declaration of Independence, then MegaHal will build a database containing text fragments such as "When in the course", "in the course of", "the course of human", "course of human events", "of human events, one", "human events, one people", and so on. Then if Megahal is fed another text, such has "Superman, Yes! It's Superman - he can change the course of mighty rivers, bend steel with his bare hands - and who disguised at Clark Kent …" IT MIGHT induce Megahal to apparently bemuse itself to proffer whether Superman can change the course of human events, or something else altogether - such as some rambling about "when in the course of mighty rivers", and so on. Thus likewise - if a phrase like "the White house said" comes up a lot in some text; then Megahal's ability to switch randomly between different contexts which otherwise share some similarity can result at times in some surprising lucidity, or else it might otherwise seem quite bizarre. == Examples == There are some sentences that MegaHAL generated: CHESS IS A FUN SPORT, WHEN PLAYED WITH SHOT GUNS. and COWS FLY LIKE CLOUDS BUT THEY ARE NEVER COMPLETELY SUCCESSFUL. == Distribution == MegaHAL is distributed under the Unlicense. Its source code can be downloaded from the Github repository. Parity problems are widely used as benchmark problems in genetic programming but inherited from the artificial neural network community. Parity is calculated by summing all the binary inputs and reporting if the sum is odd or even. This is considered difficult because: a very simple artificial neural network cannot solve it, and all inputs need to be considered and a change to any one of them changes the answer.Ni1000
MegaHAL
Parity benchmark