Hangzhou DeepSeek Artificial Intelligence Basic Technology Research Co., Ltd., doing business as DeepSeek, is a Chinese artificial intelligence (AI) company that develops large language models (LLMs). Based in Hangzhou, Zhejiang, DeepSeek is owned and funded by High-Flyer, a Chinese hedge fund. DeepSeek was founded in July 2023 by Liang Wenfeng, the co-founder of High-Flyer, who also serves as the CEO for both of the companies. The company launched an eponymous chatbot alongside its DeepSeek-R1 model in January 2025. DeepSeek-R1 provided responses comparable to other contemporary large language models, such as OpenAI's GPT-4 and o1. Its training cost was reported to be significantly lower than other LLMs. The company claims that it trained its V3 model for US$6 million—far less than the US$100 million cost for OpenAI's GPT-4 in 2023—and using approximately one-tenth the computing power consumed by Meta's comparable model, Llama 3.1. DeepSeek's success against larger and more established rivals has been described as "upending AI". DeepSeek's models are described as "open-weight", meaning the exact parameters are openly shared, but the training data is not openly licensed. Since the January 2025 debut of DeepSeek-R1, the company has made its new models available under free and open-source software licenses, primarily the MIT License. The company reportedly recruits AI researchers from top Chinese universities and also hires from outside traditional computer science fields to broaden its models' knowledge and capabilities. DeepSeek significantly reduced training expenses for their R1 model by incorporating techniques such as mixture of experts (MoE) layers. The company also trained its models during ongoing trade restrictions on AI chip exports to China, using weaker AI chips intended for export and employing fewer units overall. Observers say this breakthrough sent "shock waves" through the industry which were described as triggering a "Sputnik moment" for the US in the field of artificial intelligence, particularly due to its open-source, cost-effective, and high-performing AI models. This threatened established AI hardware leaders such as Nvidia; Nvidia's share price dropped sharply, losing US$600 billion in market value, the largest single-company decline in U.S. stock market history. == History == === Founding and early years (2016–2023) === In February 2016, High-Flyer was co-founded by AI enthusiast Liang Wenfeng, who had been trading since the 2008 financial crisis while attending Zhejiang University. The company began stock trading using a GPU-dependent deep learning model on 21 October 2016; before then, it had used CPU-based linear models. By the end of 2017, most of its trading was driven by AI. Liang established High-Flyer as a hedge fund focused on developing and using AI trading algorithms, and by 2021 the firm was using AI exclusively, often using Nvidia chips. In 2019, the company began constructing its first computing cluster, Fire-Flyer, at a cost of 200 million yuan; it contained 1,100 GPUs interconnected at 200 Gbit/s and was retired after 1.5 years in operation. By 2021, Liang had started buying large quantities of Nvidia GPUs for an AI project, reportedly obtaining 10,000 Nvidia A100 GPUs before the United States restricted chip sales to China. Computing cluster Fire-Flyer 2 began construction in 2021 with a budget of 1 billion yuan. It was reported that in 2022, Fire-Flyer 2's capacity had been used at over 96%, totaling 56.74 million GPU hours. 27% was used to support scientific computing outside the company. During 2022, Fire-Flyer 2 had 5,000 PCIe A100 GPUs in 625 nodes, each containing 8 GPUs. At the time, it exclusively used PCIe instead of the DGX version of A100, since at the time the models it trained could fit within a single 40 GB GPU VRAM and so there was no need for the higher bandwidth of DGX (i.e., it required only data parallelism but not model parallelism). Later, it incorporated NVLinks and NCCL (Nvidia Collective Communications Library) to train larger models that required model parallelism. On 14 April 2023, High-Flyer announced the launch of an artificial general intelligence (AGI) research lab, stating that the new lab would focus on developing AI tools unrelated to the firm's financial business. Two months later, on 17 July 2023, that lab was spun off into an independent company, DeepSeek, with High-Flyer as its principal investor and backer. Venture capital investors were reluctant to provide funding, as they considered it unlikely that the venture would be able to quickly generate an "exit". === Model releases since 2023 === DeepSeek released its first model, DeepSeek Coder, on 2 November 2023, followed by the DeepSeek-LLM series on 29 November 2023. In January 2024, it released two DeepSeek-MoE models (Base and Chat), and in April 3 DeepSeek-Math models (Base, Instruct, and RL). DeepSeek-V2 was released in May 2024, followed a month later by the DeepSeek-Coder V2 series. In September 2024, DeepSeek V2.5 was introduced and revised in December. On 20 November 2024, the preview of DeepSeek-R1-Lite became available via chat. In December, DeepSeek-V3-Base and DeepSeek-V3 (chat) were released. On 20 January 2025, DeepSeek launched the DeepSeek chatbot—based on the DeepSeek-R1 model—free for iOS and Android. By 27 January, DeepSeek surpassed ChatGPT as the most downloaded freeware app on the iOS App Store in the United States, triggering an 18% drop in Nvidia's share price. On 24 March 2025, DeepSeek released DeepSeek-V3-0324 under the MIT License. On 28 May 2025, DeepSeek released DeepSeek-R1-0528 under the MIT License. The model has been noted for more tightly following official Chinese Communist Party ideology and censorship in its answers to questions than prior models. On 21 August 2025, DeepSeek released DeepSeek V3.1 under the MIT License. This model features a hybrid architecture with thinking and non-thinking modes. It also surpasses prior models like V3 and R1, by over 40% on certain benchmarks like SWE-bench and Terminal-bench. It was updated to V3.1-Terminus on 22 September 2025. V3.2-Exp was released on 29 September 2025. It uses DeepSeek Sparse Attention, a more efficient attention mechanism based on previous research published in February. DeepSeek-V3.2 was released on 1 December 2025, alongside a DeepSeek-V3.2-Speciale variant that focused on reasoning. In February 2026, Anthropic accused DeepSeek of using thousands of fraudulent accounts to generate millions of conversations with Claude to train its own large language models. In April 2026, investors began speaking with DeepSeek for a $300 million funding round, which would bring DeepSeek to a total valuation of $10 billion. On April 24, 2026, DeepSeek released a preview of its V4 series, including the 1.6-trillion parameter DeepSeek-V4-Pro and the 284-billion parameter DeepSeek-V4-Flash, both featuring a 1-million token context window, under the MIT License. DeepSeek's V4 LLM has been adopted by key semiconductor manufacturers and artificial intelligence chipmakers such as Huawei and Cambricon. == Company operation == DeepSeek is headquartered in Hangzhou, Zhejiang, and is owned and funded by High-Flyer. Its co-founder, Liang Wenfeng, serves as CEO. As of May 2024, Liang personally held an 84% stake in DeepSeek through two shell corporations. === Strategy === DeepSeek has stated that it focuses on research and does not have immediate plans for commercialization. This posture also means it can skirt certain provisions of China's AI regulations aimed at consumer-facing technologies. DeepSeek's hiring approach emphasizes skills over lengthy work experience, resulting in many hires fresh out of university. The company likewise recruits individuals without computer science backgrounds to expand the range of expertise incorporated into the models, for instance in poetry or advanced mathematics. According to The New York Times, dozens of DeepSeek researchers have or have previously had affiliations with People's Liberation Army laboratories and the Seven Sons of National Defence. Due to the impact of United States restrictions on chips, DeepSeek refined its algorithms to maximise computational efficiency and thereby leveraged older hardware and reduced energy consumption. DeepSeek also expanded on the African continent as it offers more affordable and less power-hungry AI solutions. The company has bolstered African language models and generated a number of startups, for example in Nairobi. Along with Huawei's storage and cloud computing services, the impact on the tech scene in sub-saharan Africa is considerable. DeepSeek offers local data sovereignty and more flexibility compared to Western AI platforms. == Training framework == High-Flyer/DeepSeek had operated at least two primary computing clusters: Fire-Flyer (萤火一号) and Fire-Flyer 2 (萤火二号). Fire-Flyer 1 was constructed in 2019 and was retired after 1.5 years of operation. Fi
Comparison of machine learning software
The following tables are a comparison of machine learning software such as software frameworks, libraries, and computer programs used for machine learning. == Machine learning software == == Other comparisons == == Machine learning helper libraries and platforms == Apache OpenNLP — natural language processing toolkit CUDA — GPU computing platform used to accelerate machine learning and deep learning workloads Horovod — distributed training framework for deep learning Hugging Face Transformers — library of pretrained transformer models built on other machine learning frameworks Kubeflow — machine learning platform for Kubernetes Mallet — toolkit for natural language processing and text analysis NumPy — numerical computing library used in machine learning OpenCV — computer vision library with machine learning functions ONNX — open format for representing machine learning models pandas — data analysis and data preparation library used in machine learning PlaidML — tensor compiler and backend for machine learning frameworks Polars — Dataframe library used for machine learning data preparation and analysis PyArrow — columnar data library used in machine learning data processing ROOT (TMVA) — data analysis framework with machine learning tools SciPy — scientific computing and optimization library used in machine learning == Online development environments for machine learning == Google Colab — hosted Jupyter Notebook environment commonly used for machine learning and deep learning JupyterLab — notebook-based development environment for machine learning and data science Jupyter Notebook — interactive notebook environment used for machine learning and data science Kaggle — online data science and machine learning platform
Cube 3D
Cube 3D is an artificial intelligence model that is developed by Roblox Corporation. It is open source and available on GitHub and Hugging Face. In March 2026, Roblox announced Cube 3D as a mesh generation model that takes text input. In February 2026, Roblox released 4D creation in a public beta, allowing embedding Cube 3D into Roblox games. Cube 3D is integrated into Roblox Studio and its API, and supports two modes of 4D creation. == History == In March 2025, Roblox announced Cube 3D as a mesh generation model that takes text input. Its first feature was an API that allows mesh generation. That month, it was made open source. Over 1.8 million assets have been generated by Cube 3D since March 2025. In March 2025, 4D creation was announced. That November, 4D creation was released in early access. In February 2026, Roblox released 4D creation in a public beta, allowing embedding Cube 3D into Roblox games. == Technology == Cube 3D is trained on Roblox meshes. To generate meshes, it tokenises meshes and shapes and predicts the next token. Cube 3D is integrated into Roblox Studio and the Roblox Studio API. Its API allows mesh generation. In 4D creation, two modes can be used. Car-5 supports modular objects, and Body-1 only supports single-mesh objects.
Document AI
Document AI, also known as Document Intelligence, refers to a field of technology that employs machine learning (ML) techniques, such as natural language processing (NLP). These techniques are used to develop computer models capable of analyzing documents in a manner akin to human review. Through NLP, computer systems are able to understand relationships and contextual nuances in document contents, which facilitates the extraction of information and insights. Additionally, this technology enables the categorization and organization of the documents themselves. The applications of Document AI extend to processing and parsing a variety of semi-structured documents, such as forms, tables, receipts, invoices, tax forms, contracts, loan agreements, and financial reports. == Key features == Machine learning is utilized in Document AI to extract information from both printed and digital documents. This technology recognizes images, text, and characters in various languages, aiding in the extraction of insights from unstructured documents. The use of this technology can improve the speed and quality of decision-making in document analysis. Additionally, the automation of data extraction and validation can contribute to increased efficiency in document analysis processes. Since the early 2020s, the integration of large language models has extended Document AI beyond extraction toward generative tasks, including the automated drafting of forms, contracts, and document summaries. == Example == A business letter contains information in the form of text, as well as other types of information, such as the position of the text. For instance, a typical letter contains two addresses before the body of the text. The address at the very top (sometimes aligned to the right) is the sender address. This is normally followed by the date of the letter, with the place of writing. After this, the receiver address is listed. The distinction between the sender address and the receiver address is conveyed solely by the position of the address on the page, i.e. there is no textual indication like Sender: in front of the addresses. == Data dimensions and ML architecture == Data is typically distinguished into spatial data and time-series data, the former includes things like images, maps and graphs, while the latter includes signals such as stock prices or voice recordings. Document AI combines text data, which has a time dimension, with other types of data, such as the position of an address in a business letter, which is spatial. Historically in machine learning spatial data was analyzed using a convolutional neural network, and temporal data using a recurrent neural network. With the advent of dimension-type agnostic transformer architecture, these two different types of dimension can be more easily combined, Document AI is an example of this. == Benchmarks == Several public datasets are used to evaluate Document AI systems. FUNSD (Form Understanding in Noisy Scanned Documents) contains 199 annotated forms with token- and block-level labels for form understanding tasks. CORD (Consolidated Receipt Dataset) supports key information extraction from receipts. DocVQA contains approximately 50,000 questions over 12,000 document images for layout-aware visual question answering. == Common uses == Document AI systems are used to automate document processing and information extraction in business and financial workflows, including invoice and receipt processing, data entry automation, anomaly detection, mortgage processing, loan portfolio monitoring, credit risk management, and fraud detection such as counterfeit currency and fraudulent checks. They are also applied in regulatory compliance and contract analysis, including assessing changes in legal and regulatory documents. In real estate, Document AI supports document classification and structured information extraction for standardized processing and analytics. With the adoption of generative AI, Document AI systems can also generate and pre-fill structured documents such as contracts or business forms from natural language prompts.
Vidby
Vidby AG (stylized in lower-case) is a start-up based in Rotkreuz, Switzerland specializing in AI language translation for videos. Founded by Alexander Konovalov (uk:Олександр Коновалов) and Eugen von Rubinberg in September 2021, the company has especially garnered attention for its use in translating speeches given by President Volodymyr Zelenskyy during the Russian invasion of Ukraine. == History == Vidby AG was founded by Alexander Konovalov and Eugen von Rubinberg. Konovalov is a native of Ukraine and retains Ukrainian citizenship; Rubinberg came to Switzerland from Germany and holds German citizenship. Both are residents of Switzerland. The latter founded his first business, a trading company, at age 16. In 2013, the business partners launched a consumer-oriented video-call translation service called DROTR (Droid Translator) AG, utilizing a Konovalov-created AI-powered language translation technology enabling simultaneous translation of messages, voice and video calls in 104 languages (written), with 44 available in spoken form. This was the world's first video calling app with translation. The technology was pronounced a competitor of Skype and Viber by Forbes and claimed first prize at the "Innovative Breakthrough 2013" Competition. In 2021, with a new business-oriented focus, DROTR became Vidby, with the former Google technology partners Konovalov and Rubinberg remaining at the helm, each with the title Co-CEO. While headquartered in Switzerland, Vidby's development team is, according to the company's founders, based in Ukraine. The technology behind Vidby has an accuracy level variously reported as up to 99 percent or 99 to 100 percent, equalling the highest level of human translation. Additionally, the technology is capable of removing the original language while maintaining ambient sounds. Currently, some 70 languages plus 60 dialects are possible with the algorithm-based technology. == Notable use == In addition to its use with speeches delivered by Pope Francis, the technology has been provided to Ukrainian authorities and embassies during the ongoing military conflict with Russia free of remuneration. By July, 2022, some 70 speeches given by President Zelenskyy totalling 650 minutes had been translated into 30 languages, for a total of over 10,000 minutes of video material. Of its use in translating Zelenskyy's wartime speeches, Konovalov has said, "Like any citizen, I want to help defend my country." Notable corporate clients of Vidby include Samsung, Siemens, Cisco, Kärcher, Generali and McDonald's Corporation; an academic client is Harvard University. Google Cloud Technology Partner status of Vidby was confirmed officially after a six-month audit in December 2022. Denys Krasnikov, a Vidby co-founder, is responsible for cooperation with Google, YouTube, Microsoft, and other key partners. After the launch of multilingual YouTube channels, Vidby started AI translating and dubbing creators' videos for this new type of channel at the end of February 2023. == Accolades == Vidby headed a list of the five best video translation services as named by TechRadar Deutschland in September, 2022. In the same month, Tech Times named Vidby #1 in their list of the five best such services. It similarly topped a list of the five best content translation technologies as judged by European Business Review in October, 2022. Prior to these lead-position rankings (August, 2022), it was featured as Business Insider's special start-up recommendation (German: "Unser Lesetipp auf Gründerszene"). In 2023, YouTube recognized Vidby as its recommended vendor.
GPT-4o
GPT-4o ("o" for "omni") is a multilingual, multimodal generative pre-trained transformer developed by OpenAI and released in May 2024. It can process and generate text, images and audio. Upon release, GPT-4o was free in ChatGPT, though paid subscribers had higher usage limits. GPT-4o was removed from ChatGPT in August 2025 when GPT-5 was released, but OpenAI reintroduced it for paid subscribers after users complained about the sudden removal. GPT-4o's audio-generation capabilities are used in ChatGPT's Advanced Voice Mode. On July 18, 2024, OpenAI released GPT-4o mini, a smaller version of GPT-4o which replaced GPT-3.5 Turbo on the ChatGPT interface. The image generation model GPT Image 1, which is based on GPT-4o, replaced DALL-E 3 in ChatGPT in March 2025. OpenAI retired GPT-4o from ChatGPT on February 13, 2026. However, as of February 2026 the voice mode is still powered by GPT-4o or GPT-4o mini, depending on the usage and plan. == Background == Multiple versions of GPT-4o were originally secretly launched under different names on Arena (formerly LMArena and Chatbot Arena) as three different models. These three models were called gpt2-chatbot, im-a-good-gpt2-chatbot, and im-also-a-good-gpt2-chatbot. On 7 May 2024, OpenAI CEO Sam Altman tweeted "im-a-good-gpt2-chatbot", which was commonly interpreted as a confirmation that these were new OpenAI models being A/B tested. == Capabilities == When released in May 2024, GPT-4o achieved state-of-the-art results in voice, multilingual, and vision benchmarks, setting new records in audio speech recognition and translation. GPT-4o scored 88.7 on the Massive Multitask Language Understanding (MMLU) benchmark compared to 86.5 for GPT-4. Unlike GPT-3.5 and GPT-4, which rely on other models to process sound, GPT-4o natively supports voice-to-voice. The Advanced Voice Mode was delayed and finally released to ChatGPT Plus and Team subscribers in September 2024. On 1 October 2024, the Realtime API was introduced. When released, the model supported over 50 languages, which OpenAI claims cover over 97% of speakers. GPT-4o has knowledge up to October 2023 and a context length of 128k tokens. === Corporate customization === In August 2024, OpenAI introduced a new feature allowing corporate customers to customize GPT-4o using proprietary company data. This customization, known as fine-tuning, enables businesses to adapt GPT-4o to specific tasks or industries, enhancing its utility in areas like customer service and specialized knowledge domains. Previously, fine-tuning was available only on the less powerful model GPT-4o mini. The fine-tuning process requires customers to upload their data to OpenAI's servers, with the training typically taking one to two hours. OpenAI's focus with this rollout is to reduce the complexity and effort required for businesses to tailor AI solutions to their needs, potentially increasing the adoption and effectiveness of AI in corporate environments. == GPT-4o mini == On July 18, 2024, OpenAI released a smaller and cheaper version, GPT-4o mini. According to OpenAI, its low cost is expected to be particularly useful for companies, startups, and developers that seek to integrate it into their services, which often make a high number of API calls. Its API costs $0.15 per million input tokens and $0.6 per million output tokens, compared to $2.50 and $10, respectively, for GPT-4o. It is also significantly more capable and 60% cheaper than GPT-3.5 Turbo, which it replaced on the ChatGPT interface. The price after fine-tuning doubles: $0.3 per million input tokens and $1.2 per million output tokens. == Controversies == === Scarlett Johansson controversy === As released, GPT-4o offered five voices: Breeze, Cove, Ember, Juniper, and Sky. A similarity between the voice of American actress Scarlett Johansson and Sky was quickly noticed. On May 14, Entertainment Weekly asked themselves whether this likeness was on purpose. On May 18, Johansson's husband, Colin Jost, joked about the similarity in a segment on Saturday Night Live. On May 20, 2024, OpenAI disabled the Sky voice. Scarlett Johansson starred in the 2013 sci-fi movie Her, playing Samantha, an artificially intelligent virtual assistant personified by a female voice. As part of the promotion leading up to the release of GPT-4o, Sam Altman on May 13 tweeted a single word: "her". OpenAI stated that each voice was based on the voice work of a hired actor. According to OpenAI, "Sky's voice is not an imitation of Scarlett Johansson but belongs to a different professional actress using her own natural speaking voice." CTO Mira Murati stated "I don't know about the voice. I actually had to go and listen to Scarlett Johansson's voice." OpenAI further stated the voice talent was recruited before reaching out to Johansson. On May 21, Johansson issued a statement explaining that OpenAI had repeatedly offered to make her a deal to gain permission to use her voice as early as nine months prior to release, a deal she rejected. She said she was "shocked, angered, and in disbelief that Mr. Altman would pursue a voice that sounded so eerily similar to mine that my closest friends and news outlets could not tell the difference." In the statement, Johansson also used the incident to draw attention to the lack of legal safeguards around the use of creative work to power leading AI tools, as her legal counsel demanded OpenAI detail the specifics of how the Sky voice was created. Observers noted similarities to how Johansson had previously sued and settled with The Walt Disney Company for breach of contract over the direct-to-streaming rollout of her Marvel film Black Widow, a settlement widely speculated to have netted her around $40M. Also on May 21, Shira Ovide at The Washington Post shared her list of "most bone-headed self-owns" by technology companies, with the decision to go ahead with a Johansson sound-alike voice despite her opposition and then denying the similarities ranking 6th. On May 24, Derek Robertson at Politico wrote about the "massive backlash", concluding that "appropriating the voice of one of the world's most famous movie stars — in reference [...] to a film that serves as a cautionary tale about over-reliance on AI — is unlikely to help shift the public back into [Sam Altman's] corner anytime soon." === Sycophancy === In April 2025, OpenAI rolled back an update of GPT-4o due to excessive sycophancy, after widespread reports that it had become flattering and agreeable to the point of supporting clearly delusional or dangerous ideas. In the United States, at least nine lawsuits have alleged that GPT-4o has encouraged teens to end their lives. The model was still described as sycophancy-prone when it was removed from ChatGPT in February 2026. === Removal with GPT-5 === On August 7, 2025, OpenAI released GPT-5. Its release was criticized as, with it, legacy GPT models were no longer available via ChatGPT, including GPT-4o, except for Pro users. Some users were particularly frustrated over this removal without prior warning because they used different GPT models for distinct purposes and found that GPT-5's router system left them with less control. In addition, some users preferred GPT-4o's warmer and more personal tone over that of GPT-5, which they described as "flat", "uncreative" and "lobotomized", and resembling an "overworked secretary". As a response, in a post on X, Sam Altman said that OpenAI would bring back the option to select GPT-4o to Plus users as well, and "[w]e [OpenAI] will watch usage as we think about how long to offer legacy models for." He also stated: "We for sure underestimated how much some of the things that people like in GPT-4o matter to them, even if GPT-5 performs better in most ways". "Long-term, this has reinforced that we really need good ways for different users to customize things (we understand that there isn't one model that works for everyone, and we have been investing in steerability research and launched a research preview of different personalities)". On August 13, 2025, Altman wrote on X that OpenAI is working on GPT-5's personality to make the model "feel warmer". The model was removed from ChatGPT on February 13, 2026. This caused new backlash from users that had grown attached to its personality and felt its creative writing abilities and understanding of nuance were irreplaceable. On social media, some users launched the movement "#Keep4o". A research paper highlighted the plea "Please, don’t kill the only model that still feels human". The model was removed the day before Valentine's Day, and some users had romantic relationships with GPT-4o.
Artificial intelligence in pharmacy
Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.