TurboQuant is an online vector quantization algorithm for compressing high-dimensional Euclidean vectors while preserving their geometric structure. It was proposed in 2025 by Amir Zandieh, Majid Daliri, Majid Hadian, and Vahab Mirrokni in the paper TurboQuant: Online Vector Quantization with Near-optimal Distortion Rate. The paper lists Zandieh and Mirrokni as affiliated with Google Research, Daliri with New York University, and Hadian with Google DeepMind. The method was developed for applications including large language model (LLM) inference, key–value (KV) cache compression, vector databases, and nearest neighbor search. TurboQuant consists of two related algorithms: TurboQuantmse, which is optimized for mean squared error (MSE), and TurboQuantprod, which is optimized for unbiased inner product estimation. The algorithm uses a random rotation of input vectors, applies scalar quantizers to the rotated coordinates, and, for inner-product estimation, applies a one-bit Quantized Johnson–Lindenstrauss (QJL) transform to the residual error. == Background == Vector quantization is a compression method that maps high-dimensional vectors to a finite set of codewords. The problem has roots in Shannon's source coding theory and rate–distortion theory. In machine learning and information retrieval, vector quantization is used to reduce the memory required to store embeddings, activation vectors, and other numerical representations. In Transformer-based large language models, the KV cache stores key and value vectors from previous tokens during autoregressive decoding. The size of this cache grows with context length, the number of attention heads, and the number of concurrent requests, making it a major memory bottleneck in LLM serving. Similar compression problems appear in vector search, where large collections of embedding vectors must be stored and searched efficiently. Earlier approaches to vector quantization include product quantization, scalar quantization, and data-dependent k-means codebook construction. The TurboQuant paper argues that many existing methods either require offline preprocessing and calibration or suffer from suboptimal distortion guarantees in online settings. == Algorithm == === TurboQuantmse === TurboQuantmse is the version of the algorithm optimized for mean-squared error. For a unit vector x ∈ S d − 1 {\displaystyle x\in S^{d-1}} , the algorithm first applies a random rotation matrix Π ∈ R d × d {\displaystyle \Pi \in \mathbb {R} ^{d\times d}} and sets z = Π x {\displaystyle z=\Pi x} . Each coordinate of the rotated vector follows a shifted and scaled beta distribution, which converges to a normal distribution in high dimensions. In high dimensions, distinct coordinates also become nearly independent, allowing the algorithm to apply scalar quantizers independently to each coordinate. The scalar quantizer is constructed by solving a one-dimensional continuous k-means or Lloyd–Max quantization problem. If the centroids are c 1 , c 2 , … , c 2 b {\displaystyle c_{1},c_{2},\ldots ,c_{2^{b}}} , the quantization step stores, for each coordinate, i d x j = a r g m i n k ∈ [ 2 b ] | z j − c k | . {\displaystyle \mathrm {idx} _{j}=\operatorname {} {arg\,min}_{k\in [2^{b}]}|z_{j}-c_{k}|.} During dequantization, the stored index for each coordinate is replaced by the corresponding centroid, giving a reconstructed rotated vector z ~ {\displaystyle {\tilde {z}}} . The algorithm then rotates back: x ~ = Π ⊤ z ~ . {\displaystyle {\tilde {x}}=\Pi ^{\top }{\tilde {z}}.} The paper gives the following bound for TurboQuantmse: D m s e ≤ 3 π 2 ⋅ 1 4 b . {\displaystyle D_{\mathrm {mse} }\leq {\frac {\sqrt {3\pi }}{2}}\cdot {\frac {1}{4^{b}}}.} It also reports finer-grained MSE values of approximately 0.36, 0.117, 0.03, and 0.009 for bit-widths b = 1 , 2 , 3 , 4 {\displaystyle b=1,2,3,4} , respectively. === TurboQuantprod === TurboQuantprod is optimized for unbiased inner-product estimation. The authors note that an MSE-optimized quantizer may introduce bias when used to estimate inner products. To address this, TurboQuantprod first applies TurboQuantmse with bit-width b − 1 {\displaystyle b-1} , then applies a one-bit Quantized Johnson–Lindenstrauss transform to the remaining residual vector. Let r = x − Q m s e − 1 ( Q m s e ( x ) ) {\displaystyle r=x-Q_{\mathrm {mse} }^{-1}(Q_{\mathrm {mse} }(x))} be the residual after MSE quantization, and let γ = ‖ r ‖ 2 {\displaystyle \gamma =\|r\|_{2}} . The QJL step stores a sign vector for the residual. For γ ≠ 0 {\displaystyle \gamma \neq 0} , this can be written using the normalized residual u = r / γ {\displaystyle u=r/\gamma } : q j l = sign ( S u ) , {\displaystyle qjl=\operatorname {sign} (Su),} where S ∈ R d × d {\displaystyle S\in \mathbb {R} ^{d\times d}} is a random projection matrix. Since the sign function is invariant under positive rescaling, this is equivalent to sign ( S r ) {\displaystyle \operatorname {sign} (Sr)} when r ≠ 0 {\displaystyle r\neq 0} . If γ = 0 {\displaystyle \gamma =0} , the residual correction is zero. TurboQuantprod stores the MSE quantization, the QJL sign vector, and the residual norm: Q p r o d ( x ) = [ Q m s e ( x ) , q j l , γ ] . {\displaystyle Q_{\mathrm {prod} }(x)=\left[Q_{\mathrm {mse} }(x),qjl,\gamma \right].} The dequantized vector is reconstructed as x ~ = x ~ m s e + π / 2 d γ S ⊤ q j l . {\displaystyle {\tilde {x}}={\tilde {x}}_{\mathrm {mse} }+{\frac {\sqrt {\pi /2}}{d}}\,\gamma S^{\top }qjl.} The paper proves that TurboQuantprod is unbiased for inner-product estimation: E x ~ [ ⟨ y , x ~ ⟩ ] = ⟨ y , x ⟩ . {\displaystyle \mathbb {E} _{\tilde {x}}\left[\langle y,{\tilde {x}}\rangle \right]=\langle y,x\rangle .} It also gives the distortion bound D p r o d ≤ 3 π 2 ⋅ ‖ y ‖ 2 2 d ⋅ 1 4 b . {\displaystyle D_{\mathrm {prod} }\leq {\frac {\sqrt {3\pi }}{2}}\cdot {\frac {\|y\|_{2}^{2}}{d}}\cdot {\frac {1}{4^{b}}}.} == Performance and applications == The TurboQuant paper reports that the algorithm achieves near-optimal distortion rates within a small constant factor of information-theoretic lower bounds. The authors report that, for KV cache quantization, TurboQuant achieved quality neutrality at 3.5 bits per channel and marginal degradation at 2.5 bits per channel. In long-context LLM experiments using Llama 3.1 8B Instruct, the paper evaluated the method on a "needle-in-a-haystack" retrieval task with document lengths from 4,000 to 104,000 tokens. It reported that TurboQuant matched the uncompressed full-precision baseline while using more than 4× compression, and compared the method against PolarQuant, SnapKV, PyramidKV, and KIVI. Google Research stated that TurboQuant was evaluated on long-context benchmarks including LongBench, Needle in a Haystack, ZeroSCROLLS, RULER, and L-Eval using open-source models including Gemma and Mistral. According to a report in Tom's Hardware, Google described the method as reducing KV-cache memory by at least six times and achieving up to an eightfold improvement in attention-logit computation on Nvidia H100 GPUs compared with unquantized 32-bit keys. TurboQuant has also been applied to nearest-neighbor vector search. The original paper reports experiments on DBpedia entity embeddings and GloVe embeddings, comparing TurboQuant with product quantization and other vector-search quantization baselines. == Relationship to other methods == TurboQuant is related to several methods for efficient large language model inference and high-dimensional search: Product quantization – a vector quantization technique widely used for approximate nearest-neighbor search Quantization (machine learning) – reducing the numerical precision of weights, activations, or cached tensors in machine learning models PagedAttention – a memory-management algorithm for LLM serving that reduces fragmentation in the KV cache Johnson–Lindenstrauss lemma – a result in high-dimensional geometry used in random projection methods Lloyd's algorithm – an algorithm for scalar and vector quantization, including k-means-style codebook construction Unlike PagedAttention, which focuses on memory allocation and cache layout, TurboQuant reduces the numerical storage cost of the vectors themselves. Unlike many product-quantization methods, TurboQuant is designed to be data-oblivious and online, avoiding dataset-specific codebook training. == Limitations == The strongest performance claims for TurboQuant come from the original paper and Google Research's own publication. Coverage in technology media has noted that the broader impact of the method will depend on real-world implementation details, workloads, and hardware architectures.
Roadie (app)
Roadie Inc. is an American package delivery company for business and private same-day, urgent and scheduled delivery in the United States. The company was founded in 2014 and launched its web and mobile apps in January 2015. As of September 2021, it reported having over 200,000 drivers covering more than 20,000 zip codes. Roadie states it matches gig drivers with deliveries that are directed along the routes they plan to travel. Major customers include The Home Depot, Walmart, Tractor Supply Company, Best Buy and Delta Air Lines. In September 2021, UPS entered into an agreement to acquire Roadie for an undisclosed amount with the transaction expected to be closed in the fourth quarter. == History == Roadie was founded by Marc Gorlin, a co-founder of Kabbage and founder of VerticalOne and Pretty Good Privacy, as a same-day and urgent delivery company in 2014. In January 2015, Roadie launched the first consumer to consumer (C2C) version of its app with a Series A funding round of $10 million. In February, Roadie announced a partnership with Waffle House to designate its restaurants "Roadie Roadhouses", offering a neutral meeting place for drivers and senders. Drivers receive free food and drink through the partnership. In May, late-night host Jimmy Kimmel discussed the Roadie-Waffle House relationship in an opening monologue on Jimmy Kimmel Live!. Roadie's driver network expanded significantly as a result. Roadie closed a Series B round of funding in June, raising $15 million, and its first business to business (B2B) app version launched that November. In 2015, Delta Air Lines signed an agreement with Roadie to deliver mishandled luggage, becoming Roadie’s first enterprise customer. Roadie launched a pilot program with Delta at Daytona Beach International Airport. Since then, the relationship has expanded to include over 70 airports around the United States and a first mile/last mile line haul relationship with Delta Cargo. In 2017, the company signed a deal with The Home Depot, also based in Atlanta, and in February 2019, closed a Series C round of funding. In October 2019, Roadie and Delta Cargo announced a partnership to create a same-day cross-country delivery offering, DASH Door-to-Door, the first of its kind from a U.S. passenger airline. Tractor Supply Company became the first general merchandise retailer to offer same-day delivery from every store in April 2020 through Roadie. In September 2021, UPS entered an agreement to acquire Roadie for an undisclosed amount. The transaction was expected to close in the fourth quarter of 2021. Roadies, which at the time reported having 200,000 operators serving over 20,000 ZIP Codes, was expected to continue operations under its name as a separate company with no transfer of packages between the UPS and Roadies networks. The relationship between the companies goes back several years with UPS being an early investor. Earlier in 2021, UPS had begun a pilot program testing same-day deliveries via Roadies. == Operations == === On-the-way model === Roadie’s app works by connecting drivers with senders, businesses or consumers who have items that need to be delivered. Deliveries within the app are referred to as "Gigs", which Gorlin said was inspired by live music road crews, also known as roadies. A sender creates a Gig on Roadie's web app or via its API. Drivers then review deliveries in their area on their mobile app and may choose to offer to take on individual or groups of deliveries along the same route. Gigs are then assigned to drivers by Roadie's algorithm. According to the company, this model encourages drivers to choose Gigs that align with their planned schedules and routes. Roadie calls this its "on-the-way" delivery model. The go-to-market approach taken by Roadie also differs from its competitors. Rather than launching in major cities and sequentially adding new markets city-by-city, Roadie launched nationwide from its inception. The company relies on retail and airline partners to drive volume of deliveries in individual markets, which in turn builds up a network of drivers in those areas, making it easier for small businesses and consumers to send deliveries as well. This strategy allows Roadie to reach smaller cities and towns in rural or exurban communities, traditionally difficult markets for delivery providers to serve. === Service lines === Roadie’s platform is most popular for same-day, on-demand or scheduled first mile/last mile delivery, especially delivery from stores and warehouses. Some retailers also use it for returns and reverse logistics, moving inventory, and hot shot shipping. Roadie operates 1-hour grocery delivery for Walmart, and delivers perishable food items for others including small, independent retailers. The on-the-way model complements the grocery industry’s just in time model, making last-mile deliveries that do not break the cold chain. === Cross-country same-day delivery === In October 2019, Roadie and Delta Cargo launched DASH Door-to-Door, a 24/7 door-to-door pick-up and delivery service. Roadie handles the first and last mile and Delta manages the line haul via passenger flights. The service launched originally from Atlanta to 55 cities and is an industry-first for a US commercial airline. === Promotion, awards and corporate citizenship === In September 2015, Roadie announced a partnership with Atlanta-based musician Ludacris, to promote the app. Following the devastation caused by flooding in Baton Rouge in 2016, Roadie offered free pickup and delivery for all deliveries traveling to and from the Baton Rouge area. In December 2020, Walmart named Roadie its top delivery partner for "Highest Driver Customer Satisfaction" and "Highest Net Promoter Score", after expanding into general merchandise deliveries as well as grocery that same year.
Control break
In computer programming, a control break is a change in the value of one of the keys on which a file is sorted, which requires some extra processing. For example, with an input file sorted by post code, the number of items found in each postal district might need to be printed on a report, and a heading shown for the next district. Quite often there is a hierarchy of nested control breaks in a program, such as streets within districts within areas, with the need for a grand total at the end. Structured programming techniques have been developed to ensure correct processing of control breaks in languages such as COBOL and to ensure that conditions such as empty input files and sequence errors are handled properly. With fourth-generation languages such as SQL, the programming language should handle most of the details of control breaks automatically.
Simply Local
Simply Local is a decentralized community social networking and neighborhood broadcasting service developed by Simply Local, based in New Delhi. The app is used as a tool by residents to bridge the information gap and know what is happening in the locality. Simply Local creates private geo-fenced networks for people living in an area and provides social and community related services within that network. The user doesn’t post to a single person but broadcasts to a chosen community. One of its primary purposes is also to connect citizens to their elected representatives. Each community is independent of the other and information shared remains telescoped to that particular community. The app has been designed to maintain privacy and security of users and provides decentralized social networking in the sense that it forms an owner-independent, micro community, which is not connected with the world outside. Simply Local is available on Android Play and iOS App Store. It is available in two languages - English and Hindi. Simply Local’s founder and CEO is Nikhil Bapna. == History == 2020 May: Included as a Top 5 Useful App by Zee News. 2020: Used to connect candidates with local residents during the Delhi assembly elections. 2019: Renamed from Gadfly to its current name. 2018: Used for Karnataka State Elections to get detailed information on candidates. 2017: Launched under the name Gadfly as a tool to connect citizens with their elected representatives.
Backdoor (computing)
A backdoor is a typically covert method of bypassing normal authentication or encryption in a computer, product, embedded device (e.g. a home router), or its embodiment (e.g. part of a cryptosystem, algorithm, chipset, or even a "homunculus computer"—a tiny computer-within-a-computer such as that found in Intel's AMT technology). Backdoors are most often used for securing remote access to a computer, or obtaining access to plaintext in cryptosystems. From there it may be used to gain access to privileged information like passwords, corrupt or delete data on hard drives, or transfer information within compromised networks. In the United States, the 1994 Communications Assistance for Law Enforcement Act forces internet providers to provide backdoors for government authorities. In 2024, the U.S. government realized that China had been tapping communications in the U.S. using that infrastructure for months, or perhaps longer; China recorded presidential candidate campaign office phone calls—including employees of the then-vice president of the nation, and of the candidates themselves. A backdoor may take the form of a hidden part of a program, a separate program (e.g. Back Orifice may subvert the system through a rootkit), code in the firmware of the hardware, or parts of an operating system such as Windows, for example, device drivers. Trojan horses can be used to create vulnerabilities in a device. A Trojan horse may appear to be an entirely legitimate program, but when executed, it triggers an activity that may install a backdoor. Although some are secretly installed, other backdoors are deliberate and widely known. These kinds of backdoors have "legitimate" uses such as providing the manufacturer with a way to restore user passwords. Many systems that store information within the cloud fail to create accurate security measures. If many systems are connected within the cloud, hackers can gain access to all other platforms through the most vulnerable system. Default passwords (or other default credentials) can function as backdoors if they are not changed by the user. Some debugging features can also act as backdoors if they are not removed in the release version. In 1993, the United States government attempted to deploy an encryption system, the Clipper chip, with an explicit backdoor for law enforcement and national security access. The chip was unsuccessful. Recent proposals to counter backdoors include creating a database of backdoors' triggers and then using neural networks to detect them. == Overview == The threat of backdoors surfaced when multiuser and networked operating systems became widely adopted. Petersen and Turn discussed computer subversion in a paper published in the proceedings of the 1967 AFIPS Conference. They noted a class of active infiltration attacks that use "trapdoor" entry points into the system to bypass security facilities and permit direct access to data. The use of the word trapdoor here clearly coincides with more recent definitions of a backdoor. However, since the advent of public key cryptography the term trapdoor has acquired a different meaning (see: Trapdoor function), and thus the term "backdoor" is now preferred, only after the term trapdoor went out of use. More generally, such security breaches were discussed at length in a RAND Corporation task force report published under DARPA sponsorship by J.P. Anderson and D.J. Edwards in 1970. While initially targeting the computer vision domain, backdoor attacks have expanded to encompass various other domains, including text, audio, ML-based computer-aided design, and ML-based wireless signal classification. Additionally, vulnerabilities in backdoors have been demonstrated in deep generative models, reinforcement learning (e.g., AI GO), and deep graph models. These broad-ranging potential risks have prompted concerns from national security agencies regarding their potentially disastrous consequences. A backdoor in a login system might take the form of a hard coded user and password combination which gives access to the system. An example of this sort of backdoor was used as a plot device in the 1983 film WarGames, in which the architect of the "WOPR" computer system had inserted a hardcoded password-less account which gave the user access to the system, and to undocumented parts of the system (in particular, a video game-like simulation mode and direct interaction with the artificial intelligence). Although the number of backdoors in systems using proprietary software (software whose source code is not publicly available) is not widely credited, they are nevertheless frequently exposed. Programmers have even succeeded in secretly installing large amounts of benign code as Easter eggs in programs, although such cases may involve official forbearance, if not actual permission. == Examples == === Worms === Many computer worms, such as Sobig and Mydoom, install a backdoor on the affected computer (generally a PC on broadband running Microsoft Windows and Microsoft Outlook). Such backdoors appear to be installed so that spammers can send junk e-mail from the infected machines. Others, such as the Sony/BMG rootkit, placed secretly on millions of music CDs through late 2005, are intended as DRM measures—and, in that case, as data-gathering agents, since both surreptitious programs they installed routinely contacted central servers. A sophisticated attempt to plant a backdoor in the Linux kernel, exposed in November 2003, added a small and subtle code change by subverting the revision control system. In this case, a two-line change appeared to check root access permissions of a caller to the sys_wait4 function, but because it used assignment = instead of equality checking ==, it actually granted permissions to the system. This difference is easily overlooked, and could even be interpreted as an accidental typographical error, rather than an intentional attack. In January 2014, a backdoor was discovered in certain Samsung Android products, like the Galaxy devices. The Samsung proprietary Android versions are fitted with a backdoor that provides remote access to the data stored on the device. In particular, the Samsung Android software that is in charge of handling the communications with the modem, using the Samsung IPC protocol, implements a class of requests known as remote file server (RFS) commands, that allows the backdoor operator to perform via modem remote I/O operations on the device hard disk or other storage. As the modem is running Samsung proprietary Android software, it is likely that it offers over-the-air remote control that could then be used to issue the RFS commands and thus to access the file system on the device. === Object code backdoors === Harder to detect backdoors involve modifying object code, rather than source code—object code is much harder to inspect, as it is designed to be machine-readable, not human-readable. These backdoors can be inserted either directly in the on-disk object code, or inserted at some point during compilation, assembly linking, or loading—in the latter case the backdoor never appears on disk, only in memory. Object code backdoors are difficult to detect by inspection of the object code, but are easily detected by simply checking for changes (differences), notably in length or in checksum, and in some cases can be detected or analyzed by disassembling the object code. Further, object code backdoors can be removed (assuming source code is available) by simply recompiling from source on a trusted system. Thus for such backdoors to avoid detection, all extant copies of a binary must be subverted, and any validation checksums must also be compromised, and source must be unavailable, to prevent recompilation. Alternatively, these other tools (length checks, diff, checksumming, disassemblers) can themselves be compromised to conceal the backdoor, for example detecting that the subverted binary is being checksummed and returning the expected value, not the actual value. To conceal these further subversions, the tools must also conceal the changes in themselves—for example, a subverted checksummer must also detect if it is checksumming itself (or other subverted tools) and return false values. This leads to extensive changes in the system and tools being needed to conceal a single change. As object code can be regenerated by recompiling (reassembling, relinking) the original source code, making a persistent object code backdoor (without modifying source code) requires subverting the compiler itself—so that when it detects that it is compiling the program under attack it inserts the backdoor—or alternatively the assembler, linker, or loader. As this requires subverting the compiler, this in turn can be fixed by recompiling the compiler, removing the backdoor insertion code. This defense can in turn be subverted by putting a source meta-backdoor in the compiler, so that when it detects that it is compiling itself
Organoid intelligence
Organoid intelligence (OI) is an emerging field of study in computer science and biology that develops and studies biological wetware computing using 3D cultures of human brain cells (or brain organoids) and brain-machine interface technologies. Such technologies may be referred to as OIs or the nervous filesystem. Organoid intelligent computer systems can be an example of biohybrid systems. == Differences with non-organic computing == As opposed to traditional non-organic silicon-based approaches, OI seeks to use lab-grown cerebral organoids to serve as "biological hardware". While these structures are still far from being able to think like a regular human brain and do not yet possess strong computing capabilities, OI research currently offers the potential to improve the understanding of brain development, learning and memory, potentially finding treatments for neurological disorders such as dementia. Thomas Hartung, a professor from Johns Hopkins University, argued in 2023 that "while silicon-based computers are certainly better with numbers, brains are better at learning." He noted that transistor density in computer chip may be approaching its limits, whereas brains, being wired differently, are more energy-efficient and can store large amounts of information. Some researchers claim that even though human brains are slower than machines at processing simple information, they are far better at processing complex information as brains can deal with fewer and more uncertain data, perform both sequential and parallel processing, being highly heterogenous, use incomplete datasets, and is said to outperform non-organic machines in decision-making. Training OIs involve the process of biological learning (BL) as opposed to machine learning (ML) for AIs. == Bioinformatics in OI == OI generates complex biological data, necessitating sophisticated methods for processing and analysis. Bioinformatics provides the tools and techniques to decipher raw data, uncovering the patterns and insights. Researchers have developed a platform named Neuroplatform for experimenting remotely with brain organoids via an API. == Intended functions == Brain-inspired computing hardware aims to emulate the structure and working principles of the brain and could be used to address current limitations in AI technologies. However, brain-inspired silicon chips are still limited in their ability to fully mimic brain function, as most examples are built on digital electronic principles. One study performed OI computation (which they termed Brainoware) by sending and receiving information from the brain organoid using a high-density multielectrode array. By applying spatiotemporal electrical stimulation, nonlinear dynamics, and fading memory properties, as well as unsupervised learning from training data by reshaping the organoid functional connectivity, the study showed the potential of this technology by using it for speech recognition and nonlinear equation prediction in a reservoir computing framework. == Ethical concerns == While researchers are hoping to use OI and biological computing to complement traditional silicon-based computing, there are also questions about the ethics of such an approach. Concerns include the possibility that an organoid could develop sentience or consciousness, and the question of the relationship between a stem cell donor (for growing the organoid) and the respective OI system.
Electronic lab notebook
An electronic lab notebook or electronic laboratory notebook (ELN) is a computer program designed to replace paper laboratory notebooks. Lab notebooks in general are used by scientists, engineers, and technicians to document research, experiments, and procedures performed in a laboratory. A lab notebook is often maintained to be a legal document and may be used in a court of law as evidence. Similar to an inventor's notebook, the lab notebook is also often referred to in patent prosecution and intellectual property litigation. Electronic lab notebooks offer many benefits to the user as well as organizations; they are easier to search upon, simplify data copying and backups, and support collaboration amongst many users. ELNs can have fine-grained access controls, and can be more secure than their paper counterparts. They also allow the direct incorporation of data from instruments, replacing the practice of printing out data to be stapled into a paper notebook. == Types == ELNs can be divided into two categories: "Specific ELNs" contain features designed to work with specific applications, scientific instrumentation or data types. "Cross-disciplinary ELNs" or "Generic ELNs" are designed to support access to all data and information that needs to be recorded in a lab notebook. Lab Platforms that combine an ELN, LIMS, and scientific data management together, all-in-one configurable software environment. Solutions range from specialized programs designed from the ground up for use as an ELN, to modifications or direct use of more general programs. Examples of using more general software as an ELN include using OpenWetWare, a MediaWiki install (running the same software that Wikipedia uses), WordPress, or the use of general note taking software such as OneNote as an ELN. ELN's come in many different forms. They can be standalone programs, use a client-server model, or be entirely web-based. Some use a lab-notebook approach, others resemble a blog. ELNs are embracing artificial intelligence and LLM technology to provide scientific AI chat assistants. A good many variations on the "ELN" acronym have appeared. Differences between systems with different names are often subtle, with considerable functional overlap between them. Examples include "ERN" (Electronic Research Notebook), "ERMS" (Electronic Resource (or Research or Records) Management System (or Software) and SDMS (Scientific Data (or Document) Management System (or Software). Ultimately, these types of systems all strive to do the same thing: Capture, record, centralize and protect scientific data in a way that is highly searchable, historically accurate, and legally stringent, and which also promotes secure collaboration, greater efficiency, reduced mistakes and lowered total research costs. == Objectives == A good electronic laboratory notebook should offer a secure environment to protect the integrity of both data and process, whilst also affording the flexibility to adopt new processes or changes to existing processes without recourse to further software development. The package architecture should be a modular design, so as to offer the benefit of minimizing validation costs of any subsequent changes that you may wish to make in the future as your needs change. A good electronic laboratory notebook should be an "out of the box" solution that, as standard, has fully configurable forms to comply with the requirements of regulated analytical groups through to a sophisticated ELN for inclusion of structures, spectra, chromatograms, pictures, text, etc. where a preconfigured form is less appropriate. All data within the system may be stored in a database (e.g. MySQL, MS-SQL, Oracle) and be fully searchable. The system should enable data to be collected, stored and retrieved through any combination of forms or ELN that best meets the requirements of the user. The application should enable secure forms to be generated that accept laboratory data input via PCs and/or laptops / palmtops, and should be directly linked to electronic devices such as laboratory balances, pH meters, etc. Networked or wireless communications should be accommodated for by the package which will allow data to be interrogated, tabulated, checked, approved, stored and archived to comply with the latest regulatory guidance and legislation. A system should also include a scheduling option for routine procedures such as equipment qualification and study related timelines. It should include configurable qualification requirements to automatically verify that instruments have been cleaned and calibrated within a specified time period, that reagents have been quality-checked and have not expired, and that workers are trained and authorized to use the equipment and perform the procedures. == Regulatory and legal aspects == The laboratory accreditation criteria found in the ISO 17025 standard needs to be considered for the protection and computer backup of electronic records. These criteria can be found specifically in clause 4.13.1.4 of the standard. Electronic lab notebooks used for development or research in regulated industries, such as medical devices or pharmaceuticals, are expected to comply with FDA regulations related to software validation. The purpose of the regulations is to ensure the integrity of the entries in terms of time, authorship, and content. Unlike ELNs for patent protection, FDA is not concerned with patent interference proceedings, but is concerned with avoidance of falsification. Typical provisions related to software validation are included in the medical device regulations at 21 CFR 820 (et seq.) and Title 21 CFR Part 11. Essentially, the requirements are that the software has been designed and implemented to be suitable for its intended purposes. Evidence to show that this is the case is often provided by a Software Requirements Specification (SRS) setting forth the intended uses and the needs that the ELN will meet; one or more testing protocols that, when followed, demonstrate that the ELN meets the requirements of the specification and that the requirements are satisfied under worst-case conditions. Security, audit trails, prevention of unauthorized changes without substantial collusion of otherwise independent personnel (i.e., those having no interest in the content of the ELN such as independent quality unit personnel) and similar tests are fundamental. Finally, one or more reports demonstrating the results of the testing in accordance with the predefined protocols are required prior to release of the ELN software for use. If the reports show that the software failed to satisfy any of the SRS requirements, then corrective and preventive action ("CAPA") must be undertaken and documented. Such CAPA may extend to minor software revisions, or changes in architecture or major revisions. CAPA activities need to be documented as well. Aside from the requirements to follow such steps for regulated industry, such an approach is generally a good practice in terms of development and release of any software to assure its quality and fitness for use. There are standards related to software development and testing that can be applied (see ref.).