AI Generator Song Maker

AI Generator Song Maker — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

• 

  Outline of databases

  The following is provided as an overview of and topical guide to databases: Database – organized collection of data, today typically in digital form. The data are typically organized to model relevant aspects of reality (for example, the availability of rooms in hotels), in a way that supports processes requiring this information (for example, finding a hotel with vacancies). == What type of things are databases? == Databases can be described as all of the following: Information – sequence of symbols that can be interpreted as a message. Information can be recorded as signs, or transmitted as signals. Data – values of qualitative or quantitative variables, belonging to a set of items. Data in computing (or data processing) are often represented by a combination of items organized in rows and multiple variables organized in columns. Data are typically the results of measurements and can be visualised using graphs or images. Computer data – information in a form suitable for use with a computer. Data is often distinguished from programs. A program is a sequence of instructions that detail a task for the computer to perform. In this sense, data is everything in software that is not program code. == Types of databases == Active database – Database with event driven features Animation database – Database for storing and reusing animation fragments or motion capture data Back-end database – Organized collection of data in computingPages displaying short descriptions of redirect targets Bibliographic database – database of bibliographic records, an organized digital collection of references to published literature, including journal and newspaper articles, conference proceedings, reports, government and legal publications, patents, books, etc. Centralized database – database located and maintained in one location, unlike a distributed database. Cloud database – Database running on a cloud computing platform Collection database – collection catalog of a museum or archive implemented using a computerized database, in which the institution's objects or material are catalogued. Collective Optimization Database – open repository to enable sharing of benchmarks, data sets and optimization cases from the community, provide web services and Plug-in (computing)|plugins to analyze optimization data and predict program transformations or better hardware designs for multi-objective optimizations based on statistical and machine learning techniques provided there is enough information collected in the repository from multiple users. Configuration management database – Database used to store info on hardware and software assets Cooperative database – holds information on customers and their transactions. Current database – conventional database that stores data that is valid now. Directory – repository or database of information which is optimized for reading, under the assumption that data updates are very rare compared to data reads. Commonly, a directory supports search and browsing in addition to simple lookups. Distributed database – database in which storage devices are not all attached to a common CPU. Document-oriented database – computer program designed for storing, retrieving, and managing document-oriented, or Semi-structured model|semi structured data, information. EDA database – database specialized for the purpose of electronic design automation. Endgame tablebase – computerized database that contains precalculated exhaustive analysis of a chess endgame position. Food composition database (FCDB) – provides detailed information on the nutritional composition of foods. Full-text database – database that contains the complete text of books, dissertations, journals, magazines, newspapers or other kinds of textual documents. Also called a "complete-text database". Government database – collects personal information for various reasons (mass surveillance, Schengen Information System in the European Union, social security, statistics, etc.). Graph database – uses graph structures with nodes, edges, and properties to represent and store data. Knowledge base – special kind of database for knowledge management. A knowledge base provides a means for information to be collected, organised, shared, searched and utilised. Mobile database – can be connected to by a mobile computing device over a mobile network. Navigational database – database in which objects (or records) in it are found primarily by following references from other objects. Non-native speech database – speech database of non-native pronunciations of English. Online database – database accessible from a network, including from the Internet. Operational database – accessed by an Operational System to carry out regular operations of an organization. Parallel database – improves performance through parallelization of various operations, such as loading data, building indexes and evaluating queries. Probabilistic database – uncertain database in which the possible worlds have associated probabilities. Real-time database – processing system designed to handle workloads whose state is constantly changing (Buchmann). Relational database – collection of data items organized as a set of formally described tables from which data can be accessed easily. Spatial database – database that is optimized to store and query data that is related to objects in space, including points, lines and polygons. Temporal database – database with built-in time aspects, for example a temporal data model and a temporal version of Structured Query Language (SQL). Time series database – a time series is an associative array of numbers indexed by a datetime or a datetime range. These time series are often called profiles or curves, depending upon the market. A time series of stock prices might be called a price curve, or a time series of energy consumption might be called a load profile. Despite the disparate naming, the operations performed on them are sufficiently common as to demand special database treatment. Triplestore – purpose-built database for the storage and retrieval of triples, a triple being a data entity composed of subject-predicate-object, like "Bob is 35" or "Bob knows Fred". Very large database (VLDB) – contains an extremely high number of tuples (database rows), or occupies an extremely large physical filesystem storage space. Vulnerability database – platform aimed at collecting, maintaining, and disseminating information about discovered vulnerabilities targeting real computer systems. XLDB – Stands for "eXtremely Large Data Base". XML database – data stored in XML format, where it can be queried, exported and serialized into the desired format. == History of databases == History of databases – History of database management systems –: == Database use == Database usage requirements – Database theory – encapsulates a broad range of topics related to the study and research of the theoretical realm of databases and database management systems. Database machine – or is a computer or special hardware that stores and retrieves data from a database. Also called a "back end processor" Database server – computer program that provides database services to other computer programs or computers, as defined by the client-server model. Database application – computer program whose primary purpose is entering and retrieving information from a computer-managed database. Database management system (DBMS) – software package with computer programs that control the creation, maintenance, and use of a database. Database connection – facility in computer science that allows client software to communicate with database server software, whether on the same machine or not. Datasource – name given to the connection set up to a database from a server. The name is commonly used when creating a query to the database. The Database Source Name (DSN) does not have to be the same as the filename for the database. For example, a database file named "friends.mdb" could be set up with a DSN of "school". Then DSN "school" would then be used to refer to the database when performing a query. Data Source Name (DSN) – are data structures used to describe a connection to a data source. Sometimes known as a database source name though data sources are not limited to databases. Database administrator (DBA) – is a person responsible for the installation, configuration, upgrade, administration, monitoring and maintenance of physical databases. Lock – Comparison of database tools – (provides tables for comparing general and technical information for a number of available database administrator tools.) Database-centric architecture – software architectures in which databases play a crucial role. Also called "data-centric architecture". Intelligent database – was put forward as a system that manages information (rather than data) in a way that appears natural to users and which goes beyond simple record keeping. Two-phase locking (2PL) – is a

  Read more →
• 

  Salvatore J. Stolfo

  Salvatore J. Stolfo is an academic and professor of computer science at Columbia University, specializing in computer security. == Early life == Born in Brooklyn, New York, Stolfo received a Bachelor of Science degree in Computer Science and Mathematics from Brooklyn College in 1974. He received his Ph.D. from NYU Courant Institute in 1979 and has been on the faculty of Columbia ever since, where he's taught courses in Artificial Intelligence, Intrusion and Anomaly Detection Systems, Introduction to Programming, Fundamental Algorithms, Data Structures, and Knowledge-Based Expert Systems. == Academic research == While at Columbia, Stolfo has received close to $50M in funding for research that has broadly focused on Security, Intrusion Detection, Anomaly Detection, Machine Learning and includes early work in parallel computing and artificial intelligence. He has published or co-authored over 250 papers and has over 46,000 citations with an H-index of 102. In 1996 he proposed a project with DARPA that applies machine learning to behavioral patterns to detect fraud or intrusion in networks. DADO, developed by in part by Stolfo, introduced the parallel computing primitive: “Broadcast, Resolve, Report”, a hardwire implemented mechanism that today is called MapReduce. Among his earliest work, Stolfo along with colleague Greg Vesonder of Bell Labs, developed a large-scale expert data analysis system, called ACE (Automated Cable Expertise) for the nation's phone system. AT&T Bell Labs distributed ACE to a number of telephone wire centers to improve the management and scheduling of repairs in the local loop. Stolfo coined the term FOG computing (not to be confused with fog computing) where technology is used “to launch disinformation attacks against malicious insiders, preventing them from distinguishing the real sensitive customer data from fake worthless data.” In 2005 Stolfo received funding from the Army Research Office to conduct a workshop to bring together a group of researchers to help identify a research program to focus on insider threats. He was elevated to IEEE Fellow in 2018 "for his contributions to machine learning based cybersecurity." He was elected as an ACM Fellow in 2019 "for contributions to machine-learning-based cybersecurity and parallel hardware for database inference systems". == Career == Founded in 2011, Red Balloon Security (or RBS) is a cyber security company founded by Dr Sal Stolfo and Dr Ang Cui. A spinout from the IDS lab, RBS developed a symbiote technology called FRAK as a host defense for embedded systems under the sponsorship of DARPA's Cyber Fast Track program. Created based on their IDS lab research for the DARPA Active Authentication and the Anomaly Detection at Multiple Scales program, Dr Sal Stolfo and Dr. Angelos Keromytis founded Allure Security Technologies. Using active behavioral authentication and decoy technology Stolfo pioneered and patented in 1996. Founded in 2009, Allure Security Technology was created based on work done under DARPA sponsorship in Columbia's IDS lab based on DARPA prompts to research how to detect hackers once they are inside an organization's perimeter and how to continuously authenticate a user without a password. Stolfo's company Electronic Digital Documents produced a “DataBlade” technology, which Informix marketed during their strategy of acquisition and development in the mid 80's. Stolfo's patented merge/purge technology called EDD DataCleanser DataBlade was licensed by Informix. Since its acquisition by IBM in 2005, IBM Informix is one of the world's most widely used database servers, with users ranging from the world's largest corporations to startups. System Detection was one of the companies founded by Prof. Stolfo to commercialize the Anomaly Detection technology developed in the IDS lab. The company ultimately reorganized and was rebranded as Trusted Computer Solutions. That company was recently acquired by Raytheon. Recently a jury awarded Columbia University $185 million for patent infringement for one of Prof. Stolfo's inventions, the Application Communities technology. https://news.columbia.edu/news/columbia-university-awarded-185-million-patent-infringement-nortonlifelock-inc. The final order from the judge applied nearly treble damages: https://www.reuters.com/legal/litigation/gen-digital-owes-columbia-481-mln-us-patent-fight-judge-says-2023-10-02/

  Read more →
• 

  Linguistic Systems

  Linguistic Systems, Inc., also known as LSI, provides language translation services (conversion) for all media in over 115 languages. LSI focuses on the translation of legal, medical, business, institutional, academic, government and personal documents. LSI is headquartered in Cambridge, Massachusetts. == About LSI == Linguistic Systems, Inc. (LSI) was founded in 1967 by Martin Roberts. LSI's translates to/from 115 languages, DTP, audio-visual conversions, software localization, consecutive and simultaneous interpreting services, foreign brand name analysis, and machine translation with post-editing. LSI has provided translation services to over half of the Fortune 500 companies and most of the Fortune 100. Among its clients are AT&T, Boeing, Citigroup, Coca-Cola, DuPont, Exxon-Mobil, General Electric, General Motors, Hewlett-Packard, IBM, Johnson & Johnson, Pfizer, Procter & Gamble, Simon & Schuster, Time Warner, Verizon, and Walmart. As of 2013, LSI had a network of more than 7,000 translators who translate into their native languages; These include lawyers, scientists, engineers, and other bilingual professionals.

  Read more →
• 

  P4-metric

  The P4 metric (also known as FS or Symmetric F ) enables performance evaluation of a binary classifier. The P4 metric is calculated from precision, recall, specificity, and NPV (negative predictive value). The definition of the P4 metric is similar to that of the F1 metric, however the P4 metric definition addresses criticisms leveled against the definition of the F1 metric. The definition of the P4 metric may, therefore, be understood as an extension of the F1 metric. Like the other known metrics, the P4 metric is a function of: TP (true positives), TN (true negatives), FP (false positives), FN (false negatives). == Justification == The key concept of the P4 metric is to leverage the four key conditional probabilities: P ( + ∣ C + ) {\displaystyle P(+\mid C{+})} — the probability that the sample is positive, provided the classifier result was positive. P ( C + ∣ + ) {\displaystyle P(C{+}\mid +)} — the probability that the classifier result will be positive, provided the sample is positive. P ( C − ∣ − ) {\displaystyle P(C{-}\mid -)} — the probability that the classifier result will be negative, provided the sample is negative. P ( − ∣ C − ) {\displaystyle P(-\mid C{-})} — the probability the sample is negative, provided the classifier result was negative. The main assumption behind this metric is that all the probabilities mentioned above are close to 1 for a properly designed binary classifier. Indeed, P 4 = 1 {\displaystyle \mathrm {P} _{4}=1} if, and only if, all of the probabilities above are equal to 1. Another important feature is that P 4 {\displaystyle \mathrm {P} _{4}} tends to zero any of the above probabilities tend to zero. == Definition == P4 is defined as a harmonic mean of four key conditional probabilities: P 4 = 4 1 P ( + ∣ C + ) + 1 P ( C + ∣ + ) + 1 P ( C − ∣ − ) + 1 P ( − ∣ C − ) = 4 1 p r e c i s i o n + 1 r e c a l l + 1 s p e c i f i c i t y + 1 N P V . {\displaystyle \mathrm {P} _{4}={\frac {4}{{\frac {1}{P(+\mid C{+})}}+{\frac {1}{P(C{+}\mid +)}}+{\frac {1}{P(C{-}\mid -)}}+{\frac {1}{P(-\mid C{-})}}}}={\frac {4}{{\frac {1}{\mathit {precision}}}+{\frac {1}{\mathit {recall}}}+{\frac {1}{\mathit {specificity}}}+{\frac {1}{\mathit {NPV}}}}}.} In terms of TP,TN,FP,FN it can be calculated as follows: P 4 = 4 ⋅ T P ⋅ T N 4 ⋅ T P ⋅ T N + ( T P + T N ) ⋅ ( F P + F N ) . {\displaystyle \mathrm {P} _{4}={\frac {4\cdot \mathrm {TP} \cdot \mathrm {TN} }{4\cdot \mathrm {TP} \cdot \mathrm {TN} +(\mathrm {TP} +\mathrm {TN} )\cdot (\mathrm {FP} +\mathrm {FN} )}}.} == Evaluation of the binary classifier performance == Evaluating the performance of binary classifiers is a multidisciplinary concept. It spans from the evaluation of medical tests, psychiatric tests to machine learning classifiers from a variety of fields. Thus, many of the metrics in use exist under several names, some defined independently. == Properties of P4 metric == Symmetry — contrasting to the F1 metric, P4 is symmetrical. It means - it does not change its value when dataset labeling is changed - positives named negatives and negatives named positives. Range: P 4 ∈ [ 0 , 1 ] {\displaystyle \mathrm {P} _{4}\in [0,1]} . Achieving P 4 ≈ 1 {\displaystyle \mathrm {P} _{4}\approx 1} requires all the key four conditional probabilities being close to 1. For P 4 ≈ 0 {\displaystyle \mathrm {P} _{4}\approx 0} it is sufficient that one of the key four conditional probabilities is close to 0. == Examples, comparing with the other metrics == Dependency table for selected metrics ("true" means depends, "false" - does not depend): Metrics that do not depend on a given probability are prone to misrepresentation when the probability approaches 0. === Example 1: Rare disease detection test === Let us consider a medical test used to detect a rare disease. Suppose a population size of 100000 and 0.05% of the population is infected. Further suppose the following test performance: 95% of all positive individuals are classified correctly (TPR=0.95) and 95% of all negative individuals are classified correctly (TNR=0.95). In such a case, due to high population imbalance and in spite of having high test accuracy (0.95), the probability that an individual who has been classified as positive is in fact positive is very low: P ( + ∣ C + ) = 0.0095. {\displaystyle P(+\mid C{+})=0.0095.} We can observe how this low probability is reflected in some of the metrics: P 4 = 0.0370 {\displaystyle \mathrm {P} _{4}=0.0370} , F 1 = 0.0188 {\displaystyle \mathrm {F} _{1}=0.0188} , J = 0.9100 {\displaystyle \mathrm {J} =\mathbf {0.9100} } (Informedness / Youden index), M K = 0.0095 {\displaystyle \mathrm {MK} =0.0095} (Markedness). === Example 2: Image recognition — cats vs dogs === Consider the problem of training a neural network based image classifier with only two types of images: those containing dogs (labeled as 0) and those containing cats (labeled as 1). Thus, the goal is to distinguish between the cats and dogs. Suppose that the classifier overpredicts in favour of cats ("positive" samples): 99.99% of cats are classified correctly and only 1% of dogs are classified correctly. Further, suppose that the image dataset consists of 100000 images, 90% of which are pictures of cats and 10% are pictures of dogs. In this situation, the probability that the picture containing dog will be classified correctly is pretty low: P ( C − | − ) = 0.01. {\displaystyle P(C-|-)=0.01.} Not all metrics are notice this low probability: P 4 = 0.0388 {\displaystyle \mathrm {P} _{4}=0.0388} , F 1 = 0.9478 {\displaystyle \mathrm {F} _{1}=\mathbf {0.9478} } , J = 0.0099 {\displaystyle \mathrm {J} =0.0099} (Informedness / Youden index), M K = 0.8183 {\displaystyle \mathrm {MK} =\mathbf {0.8183} } (Markedness).

  Read more →
• 

  Two-phase locking

  In databases and transaction processing, two-phase locking (2PL) is a pessimistic concurrency control method that guarantees conflict-serializability. It is also the name of the resulting set of database transaction schedules (histories). The protocol uses locks, applied by a transaction to data, which may block (interpreted as signals to stop) other transactions from accessing the same data during the transaction's life. By the 2PL protocol, locks are applied and removed in two phases: Expanding phase: locks are acquired and no locks are released. Shrinking phase: locks are released and no locks are acquired. Two types of locks are used by the basic protocol: Shared and Exclusive locks. Refinements of the basic protocol may use more lock types. Using locks that block processes, 2PL, S2PL, and SS2PL may be subject to deadlocks that result from the mutual blocking of two or more transactions. == Read and write locks == Locks are used to guarantee serializability. A transaction is holding a lock on an object if that transaction has acquired a lock on that object which has not yet been released. For 2PL, the only used data-access locks are read-locks (shared locks) and write-locks (exclusive locks). Below are the rules for read-locks and write-locks: A transaction is allowed to read an object if and only if it is holding a read-lock or write-lock on that object. A transaction is allowed to write an object if and only if it is holding a write-lock on that object. A schedule (i.e., a set of transactions) is allowed to hold multiple locks on the same object simultaneously if and only if none of those locks are write-locks. If a disallowed lock attempts on being held simultaneously, it will be blocked. == Variants == Note that all conflict serializable schedules are also view serializable (but not vice-versa). === Two-phase locking === According to the two-phase locking protocol, each transaction handles its locks in two distinct, consecutive phases during the transaction's execution: Expanding phase (aka Growing phase): locks are acquired and no locks are released (the number of locks can only increase). Shrinking phase (aka Contracting phase): locks are released and no locks are acquired. The two phase locking rules can be summarized as: each transaction must never acquire a lock after it has released a lock. The serializability property is guaranteed for a schedule with transactions that obey this rule. Typically, without explicit knowledge in a transaction on end of phase 1, the rule is safely determined only when a transaction has completed processing and requested commit. In this case, all the locks can be released at once (phase 2). === Conservative two-phase locking === Conservative two-phase locking (C2PL) differs from 2PL in that transactions obtain all the locks they need before the actual execution begins. This is to ensure that a transaction that already holds some locks will not block waiting for other locks. C2PL prevents deadlocks. In cases of heavy lock contention, C2PL reduces the time locks are held on average, relative to 2PL and Strict 2PL, because transactions that hold locks are never blocked. In light lock contention, C2PL holds more locks than is necessary, because it is difficult to predict which locks will be needed in the future, thus leading to higher overhead. A C2PL transaction will not obtain any locks if it cannot obtain all the locks it needs in its initial request. Furthermore, each transaction needs to declare its read and write set (the data items that will be read/written), which is not always possible. Because of these limitations, C2PL is not used very frequently. === Strict two-phase locking === To comply with the strict two-phase locking (S2PL) protocol, a transaction needs to comply with 2PL, and release its write (exclusive) locks only after the transaction has ended (i.e., either committed or aborted). On the other hand, read (shared) locks are released regularly during the shrinking phase. Unlike 2PL, S2PL provides strictness (a special case of cascade-less recoverability). This protocol is not appropriate in B-trees because it causes Bottleneck (while B-trees always starts searching from the parent root). === Strong strict two-phase locking === or Rigorousness, or Rigorous scheduling, or Rigorous two-phase locking To comply with strong strict two-phase locking (SS2PL), a transaction's read and write locks are released only after that transaction has ended (i.e., either committed or aborted). A transaction obeying SS2PL has only a phase 1 and lacks a phase 2 until the transaction has completed. Every SS2PL schedule is also an S2PL schedule, but not vice versa.

  Read more →
• 

  Phraselator

  The Phraselator is a weatherproof handheld language translation device developed by Applied Data Systems and VoxTec, a former division of the military contractor Marine Acoustics, located in Annapolis, Maryland, USA. It was designed to serve as a handheld computer device that translates English into one of 40 different languages. == The device == The Phraselator is a small speech translation PDA-sized device designed to aid in interpretation. The device does not produce synthesized speech like that utilized by Stephen Hawking; instead, it plays pre-recorded foreign language MP3 files. Users can select the phrase they wish to convey from an English list on the screen or speak into the device. It then uses speech recognition technology called DynaSpeak, developed by SRI International, to play the proper sound file. The accuracy of the speech recognition software is over 70 percent according to software developer Jack Buchanan. The device can also record replies for translation later. Pre-recorded phrases are stored on Secure Digital flash memory cards. A 128 MB card can hold up to 12,000 phrases in four or five languages. Users can download phrase modules from the official website, which contained over 300,000 phrases as of March 2005. Users can also construct their own custom phrase modules. Earlier devices were known to have run on an SA-1110 Strong Arm 206 MHz CPU with 32MB SDRAM and 32MB onboard Flash RAM. A newer model, the P2, was released in 2004 and developed according to feedback from U.S. soldiers. It translates one way from English to approximately 60 other languages. It has a directional microphone, a larger library of phrases and a longer battery life. The 2004 release was created by and utilizes a computer board manufactured by InHand Electronics, Inc. In the future, the device will be able to display pictures so users can ask questions such as "Have you seen this person?" Developer Ace Sarich notes that the device is inferior to human interpreter. Conclusions derived from a Nepal field test conducted by U.S. and Nepal based NGO Himalayan Aid in 2004 seemed to confirm Sarich's comparisons: The very concept of using a machine as a communication point between individuals seemed to actually encourage a more limited form of interaction between tester and respondent. Usually, when limited language skills are present between parties, the genuine struggle and desire to communicate acts as a display of good will – we openly display our weakness in this regard – and the result is a more relaxed and human encounter. This was not necessarily present with the Phraselator as all parties abandoned learning about each other and instead focused on learning how to work with the device. As a tool for bridging any cultural differences or communicating effectively at any length, the Phraselator would not be recommended. This device, at least in the form tested, would best be used in large-scale operations where there is no time for language training and there is a need to communicate fixed ideas, quickly, over the greatest distance by employing large amounts of unskilled users. Large humanitarian or natural disasters in remote areas of third-world countries might be an effective example. == Origin == The original idea for the device came from Lee Morin, a Navy doctor in Operation Desert Storm. To communicate with patients, he played Arabic audio files from his laptop. He informed Ace Sarich, the vice president of VoxTec, about the idea. VoxTec won a DARPA Small Business Innovation Research grant in early 2001 to develop a military-grade handheld phrase translator. During its development, the Phraselator was tested and evaluated by scientists from the Army Research Laboratory. The device was first field tested in Afghanistan in 2001. By 2002, about 500 Phraselators were built for soldiers around the world with another 250 ordered by the U.S. Special Forces. The device cost $2000 to develop and could convert spoken English into one of 200,000 recorded commands and questions in 30 languages. However, the device could only translate one-way. At the time, the only existing two-way voice translator that could convert speech back and forth between languages was the Audio Voice Translation Guide System, or TONGUES, which was developed by Carnegie Mellon University for Lockheed Martin. As part of a DARPA program known as the Spoken Language Communication and Translation System for Tactical Use, SRI International has further developed two-way translation software for use in Iraq called IraqComm in 2006 which contains a vocabulary of 40,000 English words and 50,000 words in Iraqi Arabic. == Notable users == The handheld translator was recently used by U.S. troops while providing relief to tsunami victims in early 2005. About 500 prototypes of the device were provided to U.S. military forces in Operation Enduring Freedom. Units loaded with Haitian dialects have been provided to U.S. troops in Haiti. Army military police have used it in Kandahar to communicate with POWs. In late 2004, the U.S. Navy began to augment some ships with a version of the device attached to large speakers in order to broadcast clear voice instructions up to 400 yards (370 m) away. Corrections officers and law enforcement in Oneida County, New York, have tested the device. Hospital emergency rooms and health departments have also evaluated it. Several Native American tribes such as the Choctaw Nation, the Ponca, and the Comanche Nation have also used the device to preserve their dying languages. Various law enforcement agencies, such as the Los Angeles Police Department, also use the phraselator in their patrol cars. == Awards == In March 2004, DARPA director Dr. Tony Tether presented the Small Business Innovative Research Award to the VoxTec division of Marine Acoustics at DARPATech 2004 in Anaheim, CA. The device was recently listed as one of "Ten Emerging Technologies That Will Change Your World" in MIT's Technology Review. == Pop culture == Software developer Jack Buchanan believes that building a device similar to the fictional universal translator seen in Star Trek would be harder than building the Enterprise. The device was mentioned in a list of "Top 10 Star Trek Tech" on Space.com.

  Read more →
• 

  Baum–Welch algorithm

  In electrical engineering, statistical computing and bioinformatics, the Baum–Welch algorithm is a special case of the expectation–maximization algorithm used to find the unknown parameters of a hidden Markov model (HMM). It makes use of the forward-backward algorithm to compute the statistics for the expectation step. The Baum–Welch algorithm, the primary method for inference in hidden Markov models, is numerically unstable due to its recursive calculation of joint probabilities. As the number of variables grows, these joint probabilities become increasingly small, leading to the forward recursions rapidly approaching values below machine precision. == History == The Baum–Welch algorithm was named after its inventors Leonard E. Baum and Lloyd R. Welch. The algorithm and the Hidden Markov models were first described in a series of articles by Baum and his peers at the IDA Center for Communications Research, Princeton in the late 1960s and early 1970s. One of the first major applications of HMMs was to the field of speech processing. In the 1980s, HMMs were emerging as a useful tool in the analysis of biological systems and information, and in particular genetic information. They have since become an important tool in the probabilistic modeling of genomic sequences. == Description == A hidden Markov model describes the joint probability of a collection of "hidden" and observed discrete random variables. It relies on the assumption that the i-th hidden variable given the (i − 1)-th hidden variable is independent of previous hidden variables, and the current observation variables depend only on the current hidden state. The Baum–Welch algorithm uses the well known EM algorithm to find the maximum likelihood estimate of the parameters of a hidden Markov model given a set of observed feature vectors. Let X t {\displaystyle X_{t}} be a discrete hidden random variable with N {\displaystyle N} possible values (i.e. We assume there are N {\displaystyle N} states in total). We assume the P ( X t ∣ X t − 1 ) {\displaystyle P(X_{t}\mid X_{t-1})} is independent of time t {\displaystyle t} , which leads to the definition of the time-independent stochastic transition matrix A = { a i j } = P ( X t = j ∣ X t − 1 = i ) . {\displaystyle A=\{a_{ij}\}=P(X_{t}=j\mid X_{t-1}=i).} The initial state distribution (i.e. when t = 1 {\displaystyle t=1} ) is given by π i = P ( X 1 = i ) . {\displaystyle \pi _{i}=P(X_{1}=i).} The observation variables Y t {\displaystyle Y_{t}} can take one of K {\displaystyle K} possible values. We also assume the observation given the "hidden" state is time independent. The probability of a certain observation y i {\displaystyle y_{i}} at time t {\displaystyle t} for state X t = j {\displaystyle X_{t}=j} is given by b j ( y i ) = P ( Y t = y i ∣ X t = j ) . {\displaystyle b_{j}(y_{i})=P(Y_{t}=y_{i}\mid X_{t}=j).} Taking into account all the possible values of Y t {\displaystyle Y_{t}} and X t {\displaystyle X_{t}} , we obtain the N × K {\displaystyle N\times K} matrix B = { b j ( y i ) } {\displaystyle B=\{b_{j}(y_{i})\}} where b j {\displaystyle b_{j}} belongs to all the possible states and y i {\displaystyle y_{i}} belongs to all the observations. An observation sequence is given by Y = ( Y 1 = y 1 , Y 2 = y 2 , … , Y T = y T ) {\displaystyle Y=(Y_{1}=y_{1},Y_{2}=y_{2},\ldots ,Y_{T}=y_{T})} . Thus we can describe a hidden Markov chain by θ = ( A , B , π ) {\displaystyle \theta =(A,B,\pi )} . The Baum–Welch algorithm finds a local maximum for θ ∗ = a r g m a x θ ⁡ P ( Y ∣ θ ) {\displaystyle \theta ^{}=\operatorname {arg\,max} _{\theta }P(Y\mid \theta )} (i.e. the HMM parameters θ {\displaystyle \theta } that maximize the probability of the observation). === Algorithm === Set θ = ( A , B , π ) {\displaystyle \theta =(A,B,\pi )} with random initial conditions. They can also be set using prior information about the parameters if it is available; this can speed up the algorithm and also steer it toward the desired local maximum. ==== Forward procedure ==== Let α i ( t ) = P ( Y 1 = y 1 , … , Y t = y t , X t = i ∣ θ ) {\displaystyle \alpha _{i}(t)=P(Y_{1}=y_{1},\ldots ,Y_{t}=y_{t},X_{t}=i\mid \theta )} , the probability of seeing the observations y 1 , y 2 , … , y t {\displaystyle y_{1},y_{2},\ldots ,y_{t}} and being in state i {\displaystyle i} at time t {\displaystyle t} . This is found recursively: α i ( 1 ) = π i b i ( y 1 ) , {\displaystyle \alpha _{i}(1)=\pi _{i}b_{i}(y_{1}),} α i ( t + 1 ) = b i ( y t + 1 ) ∑ j = 1 N α j ( t ) a j i . {\displaystyle \alpha _{i}(t+1)=b_{i}(y_{t+1})\sum _{j=1}^{N}\alpha _{j}(t)a_{ji}.} Since this series converges exponentially to zero, the algorithm will numerically underflow for longer sequences. However, this can be avoided in a slightly modified algorithm by scaling α {\displaystyle \alpha } in the forward and β {\displaystyle \beta } in the backward procedure below. ==== Backward procedure ==== Let β i ( t ) = P ( Y t + 1 = y t + 1 , … , Y T = y T ∣ X t = i , θ ) {\displaystyle \beta _{i}(t)=P(Y_{t+1}=y_{t+1},\ldots ,Y_{T}=y_{T}\mid X_{t}=i,\theta )} that is the probability of the ending partial sequence y t + 1 , … , y T {\displaystyle y_{t+1},\ldots ,y_{T}} given starting state i {\displaystyle i} at time t {\displaystyle t} . We calculate β i ( t ) {\displaystyle \beta _{i}(t)} as, β i ( T ) = 1 , {\displaystyle \beta _{i}(T)=1,} β i ( t ) = ∑ j = 1 N β j ( t + 1 ) a i j b j ( y t + 1 ) . {\displaystyle \beta _{i}(t)=\sum _{j=1}^{N}\beta _{j}(t+1)a_{ij}b_{j}(y_{t+1}).} ==== Update ==== We can now calculate the temporary variables, according to Bayes' theorem: γ i ( t ) = P ( X t = i ∣ Y , θ ) = P ( X t = i , Y ∣ θ ) P ( Y ∣ θ ) = α i ( t ) β i ( t ) ∑ j = 1 N α j ( t ) β j ( t ) , {\displaystyle \gamma _{i}(t)=P(X_{t}=i\mid Y,\theta )={\frac {P(X_{t}=i,Y\mid \theta )}{P(Y\mid \theta )}}={\frac {\alpha _{i}(t)\beta _{i}(t)}{\sum _{j=1}^{N}\alpha _{j}(t)\beta _{j}(t)}},} which is the probability of being in state i {\displaystyle i} at time t {\displaystyle t} given the observed sequence Y {\displaystyle Y} and the parameters θ {\displaystyle \theta } ξ i j ( t ) = P ( X t = i , X t + 1 = j ∣ Y , θ ) = P ( X t = i , X t + 1 = j , Y ∣ θ ) P ( Y ∣ θ ) = α i ( t ) a i j β j ( t + 1 ) b j ( y t + 1 ) ∑ k = 1 N ∑ w = 1 N α k ( t ) a k w β w ( t + 1 ) b w ( y t + 1 ) , {\displaystyle \xi _{ij}(t)=P(X_{t}=i,X_{t+1}=j\mid Y,\theta )={\frac {P(X_{t}=i,X_{t+1}=j,Y\mid \theta )}{P(Y\mid \theta )}}={\frac {\alpha _{i}(t)a_{ij}\beta _{j}(t+1)b_{j}(y_{t+1})}{\sum _{k=1}^{N}\sum _{w=1}^{N}\alpha _{k}(t)a_{kw}\beta _{w}(t+1)b_{w}(y_{t+1})}},} which is the probability of being in state i {\displaystyle i} and j {\displaystyle j} at times t {\displaystyle t} and t + 1 {\displaystyle t+1} respectively given the observed sequence Y {\displaystyle Y} and parameters θ {\displaystyle \theta } . The denominators of γ i ( t ) {\displaystyle \gamma _{i}(t)} and ξ i j ( t ) {\displaystyle \xi _{ij}(t)} are the same ; they represent the probability of making the observation Y {\displaystyle Y} given the parameters θ {\displaystyle \theta } . The parameters of the hidden Markov model θ {\displaystyle \theta } can now be updated: π i ∗ = γ i ( 1 ) , {\displaystyle \pi _{i}^{}=\gamma _{i}(1),} which is the expected frequency spent in state i {\displaystyle i} at time 1 {\displaystyle 1} . a i j ∗ = ∑ t = 1 T − 1 ξ i j ( t ) ∑ t = 1 T − 1 γ i ( t ) , {\displaystyle a_{ij}^{}={\frac {\sum _{t=1}^{T-1}\xi _{ij}(t)}{\sum _{t=1}^{T-1}\gamma _{i}(t)}},} which is the expected number of transitions from state i to state j compared to the expected total number of transitions starting in state i, including from state i to itself. The number of transitions starting in state i is equivalent to the number of times state i is observed in the sequence from t = 1 to t = T − 1. b i ∗ ( v k ) = ∑ t = 1 T 1 y t = v k γ i ( t ) ∑ t = 1 T γ i ( t ) , {\displaystyle b_{i}^{}(v_{k})={\frac {\sum _{t=1}^{T}1_{y_{t}=v_{k}}\gamma _{i}(t)}{\sum _{t=1}^{T}\gamma _{i}(t)}},} where 1 y t = v k = { 1 if y t = v k , 0 otherwise {\displaystyle 1_{y_{t}=v_{k}}={\begin{cases}1&{\text{if }}y_{t}=v_{k},\\0&{\text{otherwise}}\end{cases}}} is an indicator function, and b i ∗ ( v k ) {\displaystyle b_{i}^{}(v_{k})} is the expected number of times the output observations have been equal to v k {\displaystyle v_{k}} while in state i {\displaystyle i} over the expected total number of times in state i {\displaystyle i} . These steps are now repeated iteratively until a desired level of convergence. Note: It is possible to over-fit a particular data set. That is, P ( Y ∣ θ final ) > P ( Y ∣ θ true ) {\displaystyle P(Y\mid \theta _{\text{final}})>P(Y\mid \theta _{\text{true}})} . The algorithm also does not guarantee a global maximum. ==== Multiple sequences ==== The algorithm described thus far assumes a single observed sequence Y = y 1 , … , y T {\displaystyle Y=y_{1},\ldots ,y_{T}} . However, in many situations, there are several sequences observed: Y 1 ,

  Read more →
• 

  Best AI Presentation Makers in 2026

  In search of the best AI presentation maker? An AI presentation maker is software that uses machine learning to help you get more done — it turns a rough idea into a polished result in seconds. When choosing one, weigh output quality, pricing, export formats, and how well it fits the tools you already use. Whether you are a beginner or a pro, the right AI presentation maker slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.

  Read more →
• 

  Gallery software

  Gallery software is software that helps the user publish or share photos, pictures, videos or other digital media. Most galleries are located on Web servers, where users are allowed to register and publish their pictures. Gallery software usually features automatic image resizing, allows digital media be categorized into sets, and allows comments. == Types == Early digital media publishing and sharing was done with imageboards. The boards are by topics, sometimes called "chan". Each discussion in a "chan" are started with a piece of digital media, and follow-up discussions can contain another piece too. Software works in this way: Futallaby, Danbooru. Traditionally, galleries are managed. An administrator maintains a set of or hierarchy of albums. The users can upload their digital media in one of the existing albums defined by an administrator, or create their own albums. The users with sufficient permission can re-categorise the digital media others uploaded. Often, the site's administrator can define which album the users are allowed to categorise their media into, or delete other user's content. Examples are open source galleries Coppermine, Gallery Project. There are decentralised gallery software that does not have an administrator for managing contents. Pinterest, Flickr and DeviantArt has been successful with this model. Open source gallery software MediaGoblin works in this way. Each user can create their own "collections", to categorise theirs or other users' media. However users cannot put media into other user's collections. Each user's category is separate. There is no centralised theme or hierarchy for the media.

  Read more →
• 

  Sudip Roy (computer scientist)

  Sudip Roy is a computer scientist and technology executive. He is the co-founder and chief technology officer of Adaption. He has worked on large-scale machine learning systems at organizations including Google DeepMind and Cohere. == Education == Roy earned a PhD in Computer Science from Cornell University. He holds a B.Tech in Computer Science and Engineering from the Indian Institute of Technology (IIT), Kharagpur. == Career == Sudip worked at Google Brain (now part of Google DeepMind) on systems research and large-scale data management. During his tenure, he contributed to infrastructure projects including Pathways and TensorFlow Extended, which support training and inference workflows for production machine learning models. He later served as Senior Director of Engineering at Cohere, leading work on inference infrastructure and fine-tuning systems. In late 2025, he co-founded the company Adaption Labs with Sara Hooker. The company focuses on developing AI systems designed for continuous learning and adaptation. Roy’s research spans systems for AI and AI for systems, including work on optimizing system performance and compilers. His publications have appeared in conferences such as MLSys, NeurIPS, SIGMOD, and KDD. He has been a program committee member or reviewer for the conferences SIGMOD, VLDB, ICDE, and MLSys. == Awards == He is the recipient of the MLSys Outstanding Paper Award (2022) and the SIGMOD Best Paper Award (2011). He holds multiple patents in machine learning systems, including methods for learned graph optimizations and neural network-based device placement.

  Read more →
• 

  EuroMatrixPlus

  The EuroMatrixPlus is a project that ran from March 2009 to February 2012. EuroMatrixPlus succeeded a project called EuroMatrix (September 2006 to February 2009) and continued in further development and improvement of machine translation (MT) systems for languages of the European Union (EU). == Project objectives == EuroMatrixPlus focused on achieving several goals: To continue advance of MT technology (create MT systems for all official EU languages and provide other MT researchers with existing data and infrastructure). To continually expand and investigate different MT approaches and techniques; to stay open to novel combinations of methods of MT. To bring MT to the users. Users post-edit output of statistical models and the system learns from the feedback and improves itself. Two groups of users were aimed at: Professional translators and translation agencies Users who voluntarily translate texts into their native language To contribute to MT research in Europe. To produce sample application for automatic translation of news and web pages and make that application freely accessible. == Outcome == EuroMatrixPlus contributed to MT field in several ways. It continued in development of an open source statistical MT engine Moses. The project worked on research in hybrid approaches to MT (combination of rule-based and statistical techniques). Several “MT Marathons” and annual evaluation campaigns were organized by the project. The project also resulted in releasing of 196 scientific publications. The results of the work were arranged into ten work packages: WP1: Rich Tree-Based Statistical Translation WP2: Hybrid Machine Translation WP3: Advanced Learning Methods for MT WP4: Open Source Tools and Data WP5: "WikiTrans" Translation Environments WP6: Integrated Localisation Workflow WP7: Evaluation Campaign WP8: Project Management and Dissemination WP9: Integrating Slovak Language Resources WP10: HPSG-based Statistical Translation === Software and data === Here is a list of software and data that were released by the project: Appraise – an open source tool for manual evaluation of MT output BURGER – Bulgarian Resource BulTreeBank – Treebank of Bulgarian CSLM toolkit – free tool for training continuous space language models (CSLM) to large tasks Caitra – tool for post-editing MT results Europarl – European Parliament parallel corpus IRSTLM toolkit – tool for training language models Joshua – an open-source statistical machine translation decoder for hierarchical and syntax-based MT MT Server Land – an open-source architecture for MT Moses – statistical MT MultiUN Corpora – parallel corpus extracted from the United Nations Website PCEDT 2.0 – Prague Czech-English Dependency Treebank PEDT 2.0 – English part of the Prague Czech-English Dependency Treebank Slovak corpora – English-Slovak and Czech-Slovak as well as a Slovak-English and a Slovak-Czech parallel corpus Slovak treebank – A dependency treebank TermEx – RBMT-Suited Statistical Terminology Extraction Tool Treex, TectoMT == Funding == The EuroMatrixPlus project was sponsored by EU Information Society Technology program. Total cost of the project was 5 942 121 €, from which the European Union contributed 4 266 896 €. == Project members == To ensure advance in MT, several organizations that are experts in various disciplines (linguistics, computer science, mathematics, translation) were brought together to cooperate on EuroMatrixPlus. The consortium consisted of academic as well as commercial partners. Academic partners were the University of Edinburgh (United Kingdom), DFKI – German Research Centre for Artificial Intelligence (Germany), Charles University (Czech Republic), Johns Hopkins University (United States), University of Le Mans (France), Fondazione Bruno Kessler (Italy), Dublin City University (Ireland). Two institutions joined about one year into the project. These were the L'udovít Štúr Institute of Linguistics (Slovak Republic) and IICT – Institute of Information and Communication Technologies at the Bulgarian Academy of Sciences (Bulgaria). Commercial partners included Lucy Software and Services GmbH (Germany) and CEET s.r.o. (Czech Republic). Coordination of the project was in hands of DFKI with its Language Technology Lab in Saarbrücken. The principal investigator and scientific coordinator was Hans Uszkoreit, a professor of Computational Linguistics at Saarland University.

  Read more →
• 

  AI Content Generators: Free vs Paid (2026)

  Shopping for the best AI content generator? An AI content generator is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI content generator slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.

  Read more →
• 

  Multi-agent reinforcement learning

  Multi-agent reinforcement learning (MARL) is a sub-field of reinforcement learning. It focuses on studying the behavior of multiple learning agents that coexist in a shared environment. Each agent is motivated by its own rewards, and does actions to advance its own interests; in some environments these interests are opposed to the interests of other agents, resulting in complex group dynamics. Multi-agent reinforcement learning is closely related to game theory and especially repeated games, as well as multi-agent systems. Its study combines the pursuit of finding ideal algorithms that maximize rewards with a more sociological set of concepts. While research in single-agent reinforcement learning is concerned with finding the algorithm that gets the biggest number of points for one agent, research in multi-agent reinforcement learning evaluates and quantifies social metrics, such as cooperation, reciprocity, equity, social influence, language and discrimination. == Definition == Similarly to single-agent reinforcement learning, multi-agent reinforcement learning is modeled as some form of a Markov decision process (MDP). Fix a set of agents I = { 1 , . . . , N } {\displaystyle I=\{1,...,N\}} . We then define: A set S {\displaystyle S} of environment states. One set A i {\displaystyle {\mathcal {A}}_{i}} of actions for each of the agents i ∈ I = { 1 , … , N } {\displaystyle i\in I=\{1,\dots ,N\}} . P a → ( s , s ′ ) = Pr ( s t + 1 = s ′ ∣ s t = s , a → t = a → ) {\displaystyle P_{\vec {a}}(s,s')=\Pr(s_{t+1}=s'\mid s_{t}=s,{\vec {a}}_{t}={\vec {a}})} is the probability of transition (at time t {\displaystyle t} ) from state s {\displaystyle s} to state s ′ {\displaystyle s'} under joint action a → {\displaystyle {\vec {a}}} . R → a → ( s , s ′ ) {\displaystyle {\vec {R}}_{\vec {a}}(s,s')} is the immediate joint reward after the transition from s {\displaystyle s} to s ′ {\displaystyle s'} with joint action a → {\displaystyle {\vec {a}}} . In settings with perfect information, such as the games of chess and Go, the MDP would be fully observable. In settings with imperfect information, especially in real-world applications like self-driving cars, each agent would access an observation that only has part of the information about the current state. In the partially observable setting, the core model is the partially observable stochastic game in the general case, and the decentralized POMDP in the cooperative case. == Cooperation vs. competition == When multiple agents are acting in a shared environment their interests might be aligned or misaligned. MARL allows exploring all the different alignments and how they affect the agents' behavior: In pure competition settings, the agents' rewards are exactly opposite to each other, and therefore they are playing against each other. Pure cooperation settings are the other extreme, in which agents get the exact same rewards, and therefore they are playing with each other. Mixed-sum settings cover all the games that combine elements of both cooperation and competition. === Pure competition settings === When two agents are playing a zero-sum game, they are in pure competition with each other. Many traditional games such as chess and Go fall under this category, as do two-player variants of video games like StarCraft. Because each agent can only win at the expense of the other agent, many complexities are stripped away. There is no prospect of communication or social dilemmas, as neither agent is incentivized to take actions that benefit its opponent. The Deep Blue and AlphaGo projects demonstrate how to optimize the performance of agents in pure competition settings. One complexity that is not stripped away in pure competition settings is autocurricula. As the agents' policy is improved using self-play, multiple layers of learning may occur. === Pure cooperation settings === MARL is used to explore how separate agents with identical interests can communicate and work together. Pure cooperation settings are explored in recreational cooperative games such as Overcooked, as well as real-world scenarios in robotics. In pure cooperation settings all the agents get identical rewards, which means that social dilemmas do not occur. In pure cooperation settings, oftentimes there are an arbitrary number of coordination strategies, and agents converge to specific "conventions" when coordinating with each other. The notion of conventions has been studied in language and also alluded to in more general multi-agent collaborative tasks. === Mixed-sum settings === Most real-world scenarios involving multiple agents have elements of both cooperation and competition. For example, when multiple self-driving cars are planning their respective paths, each of them has interests that are diverging but not exclusive: Each car is minimizing the amount of time it's taking to reach its destination, but all cars have the shared interest of avoiding a traffic collision. Zero-sum settings with three or more agents often exhibit similar properties to mixed-sum settings, since each pair of agents might have a non-zero utility sum between them. Mixed-sum settings can be explored using classic matrix games such as prisoner's dilemma, more complex sequential social dilemmas, and recreational games such as Among Us, Diplomacy and StarCraft II. Mixed-sum settings can give rise to communication and social dilemmas. == Social dilemmas == As in game theory, much of the research in MARL revolves around social dilemmas, such as prisoner's dilemma, chicken and stag hunt. While game theory research might focus on Nash equilibria and what an ideal policy for an agent would be, MARL research focuses on how the agents would learn these ideal policies using a trial-and-error process. The reinforcement learning algorithms that are used to train the agents are maximizing the agent's own reward; the conflict between the needs of the agents and the needs of the group is a subject of active research. Various techniques have been explored in order to induce cooperation in agents: Modifying the environment rules, adding intrinsic rewards, and more. === Sequential social dilemmas === Social dilemmas like prisoner's dilemma, chicken and stag hunt are "matrix games". Each agent takes only one action from a choice of two possible actions, and a simple 2x2 matrix is used to describe the reward that each agent will get, given the actions that each agent took. In humans and other living creatures, social dilemmas tend to be more complex. Agents take multiple actions over time, and the distinction between cooperating and defecting is not as clear cut as in matrix games. The concept of a sequential social dilemma (SSD) was introduced in 2017 as an attempt to model that complexity. There is ongoing research into defining different kinds of SSDs and showing cooperative behavior in the agents that act in them. == Autocurricula == An autocurriculum (plural: autocurricula) is a reinforcement learning concept that's salient in multi-agent experiments. As agents improve their performance, they change their environment; this change in the environment affects themselves and the other agents. The feedback loop results in several distinct phases of learning, each depending on the previous one. The stacked layers of learning are called an autocurriculum. Autocurricula are especially apparent in adversarial settings, where each group of agents is racing to counter the current strategy of the opposing group. The Hide and Seek game is an accessible example of an autocurriculum occurring in an adversarial setting. In this experiment, a team of seekers is competing against a team of hiders. Whenever one of the teams learns a new strategy, the opposing team adapts its strategy to give the best possible counter. When the hiders learn to use boxes to build a shelter, the seekers respond by learning to use a ramp to break into that shelter. The hiders respond by locking the ramps, making them unavailable for the seekers to use. The seekers then respond by "box surfing", exploiting a glitch in the game to penetrate the shelter. Each "level" of learning is an emergent phenomenon, with the previous level as its premise. This results in a stack of behaviors, each dependent on its predecessor. Autocurricula in reinforcement learning experiments are compared to the stages of the evolution of life on Earth and the development of human culture. A major stage in evolution happened 2-3 billion years ago, when photosynthesizing life forms started to produce massive amounts of oxygen, changing the balance of gases in the atmosphere. In the next stages of evolution, oxygen-breathing life forms evolved, eventually leading up to land mammals and human beings. These later stages could only happen after the photosynthesis stage made oxygen widely available. Similarly, human culture could not have gone through the Industrial Revolution in the 18th century without the resources and insights gaine

  Read more →
• 

  Multiple sequence alignment

  Multiple sequence alignment (MSA) is the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. These alignments are used to infer evolutionary relationships via phylogenetic analysis and can highlight homologous features between sequences. Alignments highlight mutation events such as point mutations (single amino acid or nucleotide changes), insertion mutations and deletion mutations, and alignments are used to assess sequence conservation and infer the presence and activity of protein domains, tertiary structures, secondary structures, and individual amino acids or nucleotides. Multiple sequence alignments require more sophisticated methodologies than pairwise alignments, as they are more computationally complex. Most multiple sequence alignment programs use heuristic methods rather than global optimization because identifying the optimal alignment between more than a few sequences of moderate length is prohibitively computationally expensive. However, heuristic methods generally cannot guarantee high-quality solutions and have been shown to fail to yield near-optimal solutions on benchmark test cases. == Problem statement == Given m {\displaystyle m} sequences S i {\displaystyle S_{i}} , i = 1 , ⋯ , m {\displaystyle i=1,\cdots ,m} similar to the form below: S := { S 1 = ( S 11 , S 12 , … , S 1 n 1 ) S 2 = ( S 21 , S 22 , ⋯ , S 2 n 2 ) ⋮ S m = ( S m 1 , S m 2 , … , S m n m ) {\displaystyle S:={\begin{cases}S_{1}=(S_{11},S_{12},\ldots ,S_{1n_{1}})\\S_{2}=(S_{21},S_{22},\cdots ,S_{2n_{2}})\\\,\,\,\,\,\,\,\,\,\,\vdots \\S_{m}=(S_{m1},S_{m2},\ldots ,S_{mn_{m}})\end{cases}}} A multiple sequence alignment is taken of this set of sequences S {\displaystyle S} by inserting any amount of gaps needed into each of the S i {\displaystyle S_{i}} sequences of S {\displaystyle S} until the modified sequences, S i ′ {\displaystyle S'_{i}} , all conform to length L ≥ max { n i ∣ i = 1 , … , m } {\displaystyle L\geq \max\{n_{i}\mid i=1,\ldots ,m\}} and no values in the sequences of S {\displaystyle S} of the same column consists of only gaps. The mathematical form of an MSA of the above sequence set is shown below: S ′ := { S 1 ′ = ( S 11 ′ , S 12 ′ , … , S 1 L ′ ) S 2 ′ = ( S 21 ′ , S 22 ′ , … , S 2 L ′ ) ⋮ S m ′ = ( S m 1 ′ , S m 2 ′ , … , S m L ′ ) {\displaystyle S':={\begin{cases}S'_{1}=(S'_{11},S'_{12},\ldots ,S'_{1L})\\S'_{2}=(S'_{21},S'_{22},\ldots ,S'_{2L})\\\,\,\,\,\,\,\,\,\,\,\vdots \\S'_{m}=(S'_{m1},S'_{m2},\ldots ,S'_{mL})\end{cases}}} To return from each particular sequence S i ′ {\displaystyle S'_{i}} to S i {\displaystyle S_{i}} , remove all gaps. == Graphing approach == A general approach when calculating multiple sequence alignments is to use graphs to identify all of the different alignments. When finding alignments via graph, a complete alignment is created in a weighted graph that contains a set of vertices and a set of edges. Each of the graph edges has a weight based on a certain heuristic that helps to score each alignment or subset of the original graph. === Tracing alignments === When determining the best suited alignments for each MSA, a trace is usually generated. A trace is a set of realized, or corresponding and aligned, vertices that has a specific weight based on the edges that are selected between corresponding vertices. When choosing traces for a set of sequences it is necessary to choose a trace with a maximum weight to get the best alignment of the sequences. == Alignment methods == There are various alignment methods used within multiple sequence to maximize scores and correctness of alignments. Each is usually based on a certain heuristic with an insight into the evolutionary process. Most try to replicate evolution to get the most realistic alignment possible to best predict relations between sequences. === Dynamic programming === A direct method for producing an MSA uses the dynamic programming technique to identify the globally optimal alignment solution. For proteins, this method usually involves two sets of parameters: a gap penalty and a substitution matrix assigning scores or probabilities to the alignment of each possible pair of amino acids based on the similarity of the amino acids' chemical properties and the evolutionary probability of the mutation. For nucleotide sequences, a similar gap penalty is used, but a much simpler substitution matrix, wherein only identical matches and mismatches are considered, is typical. The scores in the substitution matrix may be either all positive or a mix of positive and negative in the case of a global alignment, but must be both positive and negative, in the case of a local alignment. For n individual sequences, the naive method requires constructing the n-dimensional equivalent of the matrix formed in standard pairwise sequence alignment. The search space thus increases exponentially with increasing n and is also strongly dependent on sequence length. Expressed with the big O notation commonly used to measure computational complexity, a naïve MSA takes O(LengthNseqs) time to produce. To find the global optimum for n sequences this way has been shown to be an NP-complete problem. In 1989, based on Carrillo-Lipman Algorithm, Altschul introduced a practical method that uses pairwise alignments to constrain the n-dimensional search space. In this approach pairwise dynamic programming alignments are performed on each pair of sequences in the query set, and only the space near the n-dimensional intersection of these alignments is searched for the n-way alignment. The MSA program optimizes the sum of all of the pairs of characters at each position in the alignment (the so-called sum of pair score) and has been implemented in a software program for constructing multiple sequence alignments. In 2019, Hosseininasab and van Hoeve showed that by using decision diagrams, MSA may be modeled in polynomial space complexity. === Progressive alignment construction === The most widely used approach to multiple sequence alignments uses a heuristic search known as progressive technique (also known as the hierarchical or tree method) developed by Da-Fei Feng and Doolittle in 1987. Progressive alignment builds up a final MSA by combining pairwise alignments beginning with the most similar pair and progressing to the most distantly related. All progressive alignment methods require two stages: a first stage in which the relationships between the sequences are represented as a phylogenetic tree, called a guide tree, and a second step in which the MSA is built by adding the sequences sequentially to the growing MSA according to the guide tree. The initial guide tree is determined by an efficient clustering method such as neighbor-joining or unweighted pair group method with arithmetic mean (UPGMA), and may use distances based on the number of identical two-letter sub-sequences (as in FASTA rather than a dynamic programming alignment). Progressive alignments are not guaranteed to be globally optimal. The primary problem is that when errors are made at any stage in growing the MSA, these errors are then propagated through to the final result. Performance is also particularly bad when all of the sequences in the set are rather distantly related. Most modern progressive methods modify their scoring function with a secondary weighting function that assigns scaling factors to individual members of the query set in a nonlinear fashion based on their phylogenetic distance from their nearest neighbors. This corrects for non-random selection of the sequences given to the alignment program. Progressive alignment methods are efficient enough to implement on a large scale for many (100s to 1000s) sequences. A popular progressive alignment method has been the Clustal family. ClustalW is used extensively for phylogenetic tree construction, in spite of the author's explicit warnings that unedited alignments should not be used in such studies and as input for protein structure prediction by homology modeling. European Bioinformatics Institute (EMBL-EBI) announced that CLustalW2 will expire in August 2015. They recommend Clustal Omega which performs based on seeded guide trees and HMM profile-profile techniques for protein alignments. An alternative tool for progressive DNA alignments is multiple alignment using fast Fourier transform (MAFFT). Another common progressive alignment method named T-Coffee is slower than Clustal and its derivatives but generally produces more accurate alignments for distantly related sequence sets. T-Coffee calculates pairwise alignments by combining the direct alignment of the pair with indirect alignments that aligns each sequence of the pair to a third sequence. It uses the output from Clustal as well as another local alignment program LALIGN, which finds multiple regions of local alignment between two sequences. The resulting alignment and phylogenetic tree are used as a guide to produce new and more accurate w

  Read more →
• 

  Top 10 AI Blog Writers Compared (2026)

  Comparing the best AI blog writer? An AI blog writer is software that uses machine learning to help you get more done — it lowers the barrier so anyone can produce professional output. Privacy matters too: check whether your data trains the model and whether a no-log or enterprise tier is available. Whether you are a beginner or a pro, the right AI blog writer slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.

  Read more →