AI Data Bias

AI Data Bias — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

Robinson compass mask

In image processing, a Robinson compass mask is a type of compass mask used for edge detection. It has eight major compass orientations, each will extract the edges in respect to its direction. A combined use of compass masks of different directions could detect the edges from different angles. == Technical explanation == The Robinson compass mask is defined by taking a single mask and rotating it to form eight orientations: North: [ − 1 0 1 − 2 0 2 − 1 0 1 ] {\displaystyle {\text{North:}}{\begin{bmatrix}-1&0&1\\-2&0&2\\-1&0&1\end{bmatrix}}} North West: [ 0 1 2 − 1 0 1 − 2 − 1 0 ] {\displaystyle {\text{North West:}}{\begin{bmatrix}0&1&2\\-1&0&1\\-2&-1&0\end{bmatrix}}} West: [ 1 2 1 0 0 0 − 1 − 2 − 1 ] {\displaystyle {\text{West:}}{\begin{bmatrix}1&2&1\\0&0&0\\-1&-2&-1\end{bmatrix}}} South West: [ 2 1 0 1 0 − 1 0 − 1 − 2 ] {\displaystyle {\text{South West:}}{\begin{bmatrix}2&1&0\\1&0&-1\\0&-1&-2\end{bmatrix}}} South: [ 1 0 − 1 2 0 − 2 1 0 − 1 ] {\displaystyle {\text{South:}}{\begin{bmatrix}1&0&-1\\2&0&-2\\1&0&-1\end{bmatrix}}} South East: [ 0 − 1 − 2 1 0 − 1 2 1 0 ] {\displaystyle {\text{South East:}}{\begin{bmatrix}0&-1&-2\\1&0&-1\\2&1&0\end{bmatrix}}} East: [ − 1 − 2 − 1 0 0 0 1 2 1 ] {\displaystyle {\text{East:}}{\begin{bmatrix}-1&-2&-1\\0&0&0\\1&2&1\end{bmatrix}}} North East: [ − 2 − 1 0 − 1 0 1 0 1 2 ] {\displaystyle {\text{North East:}}{\begin{bmatrix}-2&-1&0\\-1&0&1\\0&1&2\end{bmatrix}}} The direction axis is the line of zeros in the matrix. Robinson compass mask is similar to kirsch compass masks, but is simpler to implement. Since the matrix coefficients only contains 0, 1, 2, and are symmetrical, only the results of four masks need to be calculated, the other four results are the negation of the first four results. An edge, or contour is an tiny area with neighboring distinct pixel values. The convolution of each mask with the image would create a high value output where there is a rapid change of pixel value, thus an edge point is found. All the detected edge points would line up as edges. == Example == An example of Robinson compass masks applied to the original image. Obviously, the edges in the direction of the mask is enhanced.
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AlphaFold

AlphaFold is an artificial intelligence (AI) program developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure. It is designed using deep learning techniques. AlphaFold 1 (2018) placed first in the overall rankings of the 13th Critical Assessment of Structure Prediction (CASP) in December 2018. It was particularly successful at predicting the most accurate structures for targets rated as most difficult by the competition organizers, where no existing template structures were available from proteins with partially similar sequences. AlphaFold 2 (2020) repeated this placement in the CASP14 competition in November 2020. It achieved a level of accuracy much higher than any other entry. It scored above 90 on CASP's global distance test (GDT) for approximately two-thirds of the proteins, a test measuring the similarity between a computationally predicted structure and the experimentally determined structure, where 100 represents a complete match. The inclusion of metagenomic data has improved the quality of the prediction of multiple sequence alignments. One of the biggest sources of the training data was the custom-built Big Fantastic Database of 65,983,866 protein families, represented as multiple sequence alignments and Hidden Markov models, covering 2,204,359,010 protein sequences from reference databases, metagenomes, and metatranscriptomes. AlphaFold 2's results at CASP14 were described as "astounding" and "transformational". However, some researchers noted that the accuracy was insufficient for a third of its predictions, and that it did not reveal the underlying mechanism or rules of protein folding for the protein folding problem, which remains unsolved. Despite this, the technical achievement was widely recognized. On 15 July 2021, the AlphaFold 2 paper was published in Nature as an advance access publication alongside open source software and a searchable database of species proteomes. As of November 2025, the paper had been cited nearly 43,000 times. AlphaFold 3 was announced on 8 May 2024. It can predict the structure of complexes created by proteins with DNA, RNA, various ligands, and ions. The new prediction method shows a minimum 50% improvement in accuracy for protein interactions with other molecules compared to existing methods. Demis Hassabis and John Jumper shared one half of the 2024 Nobel Prize in Chemistry, awarded "for protein structure prediction," while the other half went to David Baker "for computational protein design." Hassabis and Jumper had previously won the Breakthrough Prize in Life Sciences and the Albert Lasker Award for Basic Medical Research in 2023 for their leadership of the AlphaFold project. == Background == Proteins consist of chains of amino acids which spontaneously fold to form the three dimensional (3-D) structures of the proteins. The 3-D structure is crucial to understanding the biological function of the protein. Protein structures can be determined experimentally through techniques such as X-ray crystallography, cryo-electron microscopy and nuclear magnetic resonance (NMR), which are all expensive and time-consuming. Such efforts, using the experimental methods, have identified the structures of about 170,000 proteins over the last 60 years, while there are over 200 million known proteins across all life forms. Over the years, researchers have applied numerous computational methods to predict the 3D structures of proteins from their amino acid sequences, accuracy of such methods in best possible scenario is close to experimental techniques (NMR) by the use of homology modeling based on molecular evolution. CASP, which was launched in 1994 to challenge the scientific community to produce their best protein structure predictions, found that GDT scores of only about 40 out of 100 can be achieved for the most difficult proteins by 2016. AlphaFold started competing in the 2018 CASP using an artificial intelligence (AI) deep learning technique. == Algorithm == DeepMind is known to have trained the program on over 170,000 protein structures from the Protein Data Bank, a public repository of protein sequences and structures. The program uses a form of attention network, a deep learning technique that focuses on having the AI identify parts of a larger problem, then piece it together to obtain the overall solution. The overall training was conducted on processing power between 100 and 200 GPUs. === AlphaFold 1 (2018) === AlphaFold 1 (2018) was built on work developed by various teams in the 2010s, work that looked at the large databases of related protein sequences now available from many different organisms (most without known 3D structures), to try to find changes at different residues (peptides) that appeared to be correlated, even though the residues were not consecutive in the main chain. Such correlations suggest that the residues may be close to each other physically, even though not close in the sequence, allowing a contact map to be estimated. Building on recent work prior to 2018, AlphaFold 1 extended this by estimating a probability distribution for the distances between residues, effectively transforming the contact map into a distance map. It also used more advanced learning methods than previously to develop the inference. The code was not made publicly available, except to run on sequences of proteins in the 2018 CASP competition. === AlphaFold 2 (2020) === The 2020 version of the program (AlphaFold 2, 2020) is significantly different from the original version that won CASP 13 in 2018, according to the team at DeepMind. AlphaFold 1 used a number of separately trained modules to produce a guide potential, which was then combined with a physics-based energy potential. AlphaFold 2 replaced this with a system of interconnected sub-networks, forming a single, differentiable, end-to-end model based on pattern recognition. This model was trained in an integrated manner. After the neural network's prediction converges, a final refinement step applies local physical constraints using energy minimization based on the AMBER force field. This step only slightly adjusts the predicted structure. A key part of the 2020 system are two modules, believed to be based on a transformer design, which are used to progressively refine a vector of information for each relationship (or "edge" in graph-theory terminology) between an amino acid residue of the protein and another amino acid residue (these relationships are represented by the array shown in green); and between each amino acid position and each different sequences in the input sequence alignment (these relationships are represented by the array shown in red). Internally these refinement transformations contain layers that have the effect of bringing relevant data together and filtering out irrelevant data (the "attention mechanism") for these relationships, in a context-dependent way, learned from training data. These transformations are iterated, the updated information output by one step becoming the input of the next, with the sharpened residue/residue information feeding into the update of the residue/sequence information, and then the improved residue/sequence information feeding into the update of the residue/residue information. As the iteration progresses, according to one report, the "attention algorithm ... mimics the way a person might assemble a jigsaw puzzle: first connecting pieces in small clumps—in this case clusters of amino acids—and then searching for ways to join the clumps in a larger whole." The output of these iterations then informs the final structure prediction module, which also uses transformers, and is itself then iterated. In an example presented by DeepMind, the structure prediction module achieved a correct topology for the target protein on its first iteration, scored as having a GDT_TS of 78, but with a large number (90%) of stereochemical violations – i.e. unphysical bond angles or lengths. With subsequent iterations the number of stereochemical violations fell. By the third iteration the GDT_TS of the prediction was approaching 90, and by the eighth iteration the number of stereochemical violations was approaching zero. The training data was originally restricted to single peptide chains. However, the October 2021 update, named AlphaFold-Multimer, included protein complexes in its training data. DeepMind stated this update succeeded about 70% of the time at accurately predicting protein-protein interactions. === AlphaFold 3 (2024) === Announced on 8 May 2024, AlphaFold 3 was co-developed by Google DeepMind and Isomorphic Labs, both subsidiaries of Alphabet. AlphaFold 3 is not limited to proteins, as it can also predict the structures of protein complexes with DNA, RNA, post-translational modifications and selected ligands and ions. AlphaFold 3 introduces the "Pairformer," a deep learning architecture inspired by the transformer, which is considered similar to, but si
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Clinical quality management system

Clinical quality management systems (CQMS) are systems used in the life sciences sector (primarily in the pharmaceutical, biologics and medical device industries) designed to manage quality management best practices throughout clinical research and clinical study management. A CQMS system is designed to manage all of the documents, activities, tasks, processes, quality events, relationships, audits and training that must be administered and controlled throughout the life of a clinical trial. The premise of a CQMS is to bring together the activities led by two sectors of clinical research, Clinical Quality and Clinical Operations, to facilitate cross-functional activities to improve efficiencies and transparency and to encourage the use of risk mitigation and risk management practices at the clinical study level. Based on the principles of quality management systems (QMS) which are used in many industries to create a framework for defining and delivering quality outcomes, managing risk, and continual improvement. Many guidelines and governance bodies have been established to ensure a common approach within a given industry to a set of parameters used to identify the minimally acceptable standard for that industry. The pharmaceutical industry is no exception, with several trade groups (e.g. PhRMA, EFPIA, RQA, etc.) coming together to enhance collaboration. However, as noted by the Academy of Medical Sciences, there are increasingly complex and bureaucratic legal and ethical frameworks that innovators must work within to develop new medicines for patients. The historical pharmaceutical QMS applies primarily to good manufacturing practice as described in existing ISO (International Organization for Standardization) and ICH (International Committee on Harmonization) guidelines. "Good Manufacturing Practices (GMP) relate to quality control and quality assurance enabling companies in the pharmaceutical sector to minimize or eliminate instances of contamination, mix-ups, and errors. This in turn, protects the customer from purchasing a product which is ineffective or even dangerous." These standards have historically been applied to the manufacturing environment, appropriate to how they have been written. However, according to FDA as well as other regulatory bodies, "Implementation of ICH Q10 throughout the product lifecycle should facilitate innovation and continual improvement", implying that the same standards that apply to the manufacturing environment should also be applied to the clinical research space, earlier in the lifecycle of an investigational or marketed product. Accordingly, a CQMS is any system developed to apply these principles to clinical operations within an organization.
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Danilo McGarry

Danilo McGarry (born 1985) is a British tech executive, writer, and speaker who has led AI initiatives in finance and healthcare. == Early life and education == Danilo McGarry was born in 1985. He received a Bachelor of Science (BSc) with honors in Business Management from the University of Bath. == Career == McGarry began his career in technology and financial services, with positions at companies including Motorola, JPMorgan Chase, and BNP Paribas. He later joined the Royal Bank of Canada (RBC) as an analyst and later became a director, where he led transformation initiatives involving robotic process automation (RPA) in the bank's capital markets operations. McGarry subsequently moved into leadership roles focused on AI. At Citigroup, he served as Head of Artificial Intelligence and Machine Learning, where he launched an AI-driven robotics and automation initiative. At UnitedHealth Group (UHG), he held a senior role in the company's automation program, which utilized a large fleet of software robots in its healthcare operations. In December 2019, McGarry was appointed Global Head of AI & Automation at Alter Domus, a multinational financial services firm. In this role, he established a new AI and automation department. He left the firm in late 2023 to establish his businesses. In 2025, the Chartered Institute of Personnel and Development (CIPD) appointed him as its strategic adviser on artificial intelligence.
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DABUS

DABUS (Device for the Autonomous Bootstrapping of Unified Sentience) is an artificial intelligence (AI) system created by Stephen Thaler. It reportedly conceived of two novel products — a food container constructed using fractal geometry, which enables rapid reheating, and a flashing beacon for attracting attention in an emergency. The filing of patent applications designating DABUS as inventor has led to decisions by patent offices and courts on whether a patent can be granted for an invention reportedly made by an AI system. == History in different jurisdictions == === Australia === On 17 September 2019, Thaler filed an application to patent a "Food container and devices and methods for attracting enhanced attention," naming DABUS as the inventor. On 21 September 2020, IP Australia found that section 15(1) of the Patents Act 1990 (Cth) is inconsistent with an artificial intelligence machine being treated as an inventor, and Thaler's application had lapsed. Thaler sought judicial review, and on 30 July 2021, the Federal Court set aside IP Australia's decision and ordered IP Australia to reconsider the application. On 13 April 2022, the Full Court of the Federal Court set aside that decision, holding that only a natural person can be an inventor for the purposes of the Patents Act 1990 (Cth) and the Patents Regulations 1991 (Cth), and that such an inventor must be identified for any person to be entitled to a grant of a patent. On 11 November 2022, Thaler was refused special leave to appeal to the High Court. === European Patent Office === On 17 October 2018 and 7 November 2018, Thaler filed two European patent applications with the European Patent Office. The first claimed invention was a "Food Container" and the second was "Devices and Methods for Attracting Enhanced Attention." On 27 January 2020, the EPO rejected the applications on the grounds that the application listed an AI system named DABUS, and not a human, as the inventor, based on Article 81 and Rule 19(1) of the European Patent Convention (EPC). On 21 December 2021, the Board of Appeal of the EPO dismissed Thaler's appeal from the EPO's primary decision. The Board of Appeal confirmed that "under the EPC the designated inventor has to be a person with legal capacity. This is not merely an assumption on which the EPC was drafted. It is the ordinary meaning of the term inventor." === United Kingdom === Similar applications were filed by Thaler to the United Kingdom Intellectual Property Office on 17 October and 7 November 2018. The Office asked Thaler to file statements of inventorship and of right of grant to a patent (Patent Form 7) in respect of each invention within 16 months of the filing date. Thaler filed those forms naming DABUS as the inventor and explaining in some detail why he believed that machines should be regarded as inventors in the circumstances. His application was rejected on the grounds that: (1) naming a machine as inventor did not meet the requirements of the Patents Act 1977; and (2) the IPO was not satisfied as to the manner in which Thaler had acquired rights that would otherwise vest in the inventor. Thaler was not satisfied with the decision and asked for a hearing before an official known as the "hearing officer". By a decision dated 4 December 2019 the hearing officer rejected Thaler's appeal. Thaler appealed against the hearing officer's decision to the Patents Court (a specialist court within the Chancery Division of the High Court of England and Wales that determines patent disputes). On 21 September 2020, Mr Justice Marcus Smith upheld the decision of the hearing officer. On 21 September 2021, Thaler's further appeal to the Court of Appeal was dismissed by Arnold LJ and Laing LJ (Birss LJ dissenting). On 20 December 2023, the UK Supreme Court dismissed a further appeal by Thaler. In its judgment, the court held that an "inventor" under the Patents Act 1977 must be a natural person. === United States === The patent applications on the inventions were refused by the USPTO, which held that only natural persons can be named as inventors in a patent application. Thaler first fought this result by filing a complaint under the Administrative Procedure Act alleging that the decision was "arbitrary, capricious, an abuse of discretion and not in accordance with the law; unsupported by substantial evidence, and in excess of Defendants’ statutory authority." A month later on August 19, 2019, Thaler filed a petition with the USPTO as allowed in 37 C.F.R. § 1.181 stating that DABUS should be the inventor. The judge and Thaler agreed in this case that Thaler himself is unable to receive the patent on behalf of DABUS. In their August 5, 2022, Thaler decision, the US Court of Appeals for the Federal Circuit affirmed that only a natural person could be an inventor, which means that the AI that invents any other type of invention is not addressed by the "who" mentioned in the legislation. === New Zealand === On January 31, 2022, the Intellectual Property Office of New Zealand (IPONZ) decided that a patent application (776029) filed by Stephen Thaler was void, on the basis that no inventor was identified on the patent application. IPONZ determined that DABUS could not be "an actual devisor of the invention" as required by the Patents Act 2013, and that this must be a natural person as held by the previous patent offices above. The High Court of New Zealand confirmed the decision in 2023. === South Africa === On 24 June 2021, the South African Companies and Intellectual Property Commission (CIPC) accepted Dr Thaler's Patent Cooperation Treaty, for a patent in respect of inventions generated by DABUS. In July 2021, the CIPC released a notice of issuance for the patent. It is the first patent granted for an AI invention. === Switzerland === On June 26, 2025, the Swiss Federal Administrative Court ruled that artificial intelligence systems such as DABUS cannot be listed as inventors in patent applications. The court upheld the existing practice of the Swiss Federal Institute of Intellectual Property (IPI), which requires that only natural persons can be recognized as inventors under Swiss patent law. The case concerned a patent application, which sought to designate DABUS as the sole inventor of a food container designed with a fractal geometry to enhance heat distribution. The IPI had rejected the application, arguing that both the absence of a human inventor and the attribution of inventorship to an AI system were inadmissible. While the court dismissed Thaler's main request, it accepted a subsidiary request: if a human applicant recognizes and files a patent based on an AI-generated invention, that person may be considered the inventor. As a result, the application may proceed with Thaler listed as the inventor. The decision (B-2532/2024) can still be appealed to the Swiss Federal Supreme Court.
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Safe Superintelligence Inc.

Safe Superintelligence Inc. (SSI Inc.) is an Israeli-American artificial intelligence company founded by Ilya Sutskever, the former chief scientist of OpenAI; Daniel Gross, former head of Apple’s AI efforts; and Daniel Levy, an investor and AI researcher. The company's mission is to focus on safely developing a superintelligence, a computer-based agent capable of surpassing human intelligence. == History == On May 15, 2024, OpenAI co-founder Ilya Sutskever left OpenAI after a board dispute where he voted to fire Sam Altman amid concerns about communication and trust. Sutskever and others additionally believed that OpenAI was neglecting its original focus on safety in favor of pursuing opportunities for commercialization. On June 19, 2024, Sutskever posted on X that he was starting SSI Inc, with the goal to safely develop superintelligent AI, alongside Daniel Levy, and Daniel Gross. The company, composed of a small team, is split between Palo Alto, California and Tel Aviv, Israel. In September 2024, SSI revealed it had raised $1 billion from venture capital firms including SV Angel, DST Global, Sequoia Capital, and Andreessen Horowitz. The money will be used to build up more computing power and hire top individuals in the field. In March 2025, SSI reached a $30 billion valuation in a funding round led by Greenoaks Capital. This is six times its previous $5 billion valuation from September 2024. Despite not yet generating revenue and having approximately 20 employees, the company has attracted significant investor interest, largely due to co-founder Ilya Sutskever's reputation and its focus on developing safe superintelligence. In April 2025, Google Cloud announced a partnership to provide TPUs for SSI's research. In the first half of 2025, Meta attempted to acquire SSI but was rebuffed by Sutskever. In July 2025, co-founder Gross left the company to join Meta Superintelligence Labs, and Sutskever became the CEO of SSI.
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Stockfish (chess)

Stockfish is a free and open-source chess engine, available for various desktop and mobile platforms. It can be used in chess software through the Universal Chess Interface. Stockfish has been one of the strongest chess engines in the world for several years. It has won all main events of the Top Chess Engine Championship (TCEC) and the Chess.com Computer Chess Championship (CCC) since 2020 and, as of May 2026, is the strongest CPU chess engine in the world with an estimated Elo rating of 3653 in a time control of 40/15 (15 minutes to make 40 moves), according to CCRL. The Stockfish engine was developed by Tord Romstad, Marco Costalba, and Joona Kiiski, and was derived from Glaurung, an open-source engine by Tord Romstad released in 2004. It is now being developed and maintained by the Stockfish community. Stockfish historically used only a classical hand-crafted function to evaluate board positions, but with the introduction of the efficiently updatable neural network (NNUE) in August 2020, Stockfish 12 adopted a hybrid evaluation system that primarily used the neural network and occasionally relied on the hand-crafted evaluation. In July 2023, Stockfish removed the hand-crafted evaluation and transitioned to a fully neural network-based approach. == Features == Stockfish uses a tree-search algorithm based on alpha–beta search with several hand-designed heuristics. Stockfish represents positions using bitboards. Stockfish supports Chess960, a feature it inherited from Glaurung. Support for Syzygy tablebases, previously available in a fork maintained by Ronald de Man, was integrated into Stockfish in 2014. In 2018, support for the 7-man Syzygy was added, shortly after the tablebase was made available. Stockfish supports an unlimited number of CPU threads in multiprocessor systems, with a maximum transposition table size of 32 TB. Stockfish has been a very popular engine on various platforms. On desktop, it is the default chess engine bundled with the Internet Chess Club interface programs BlitzIn and Dasher. On mobile, it has been bundled with the Stockfish app, SmallFish and Droidfish. Other Stockfish-compatible graphical user interfaces (GUIs) include Fritz, Arena, Stockfish for Mac, and PyChess. Stockfish can be compiled to WebAssembly or JavaScript, allowing it to run in the browser. Both Chess.com and Lichess provide Stockfish in this form in addition to a server-side program. Release versions and development versions are available as C++ source code and as precompiled versions for Microsoft Windows, macOS, Linux 32-bit/64-bit and Android. == History == The program originated from Glaurung, an open-source chess engine created by Tord Romstad and first released in 2004. Four years later, Marco Costalba forked the project, naming it Stockfish because it was "produced in Norway and cooked in Italy" (Romstad is Norwegian and Costalba is Italian). The first version, Stockfish 1.0, was released in November 2008. For a while, new ideas and code changes were transferred between the two programs in both directions, until Romstad decided to discontinue Glaurung in favor of Stockfish, which was the stronger engine at the time. The last Glaurung version (2.2) was released in December 2008. Around 2011, Romstad decided to abandon his involvement with Stockfish in order to spend more time on his new iOS chess app. On 18 June 2014 Marco Costalba announced that he had "decided to step down as Stockfish maintainer" and asked that the community create a fork of the current version and continue its development. An official repository, managed by a volunteer group of core Stockfish developers, was created soon after and currently manages the development of the project. === Fishtest === Since 2013, Stockfish has been developed using a distributed testing framework named Fishtest, where volunteers can donate CPU time for testing improvements to the program. Changes to game-playing code are accepted or rejected based on results of playing of tens of thousands of games on the framework against an older "reference" version of the program, using sequential probability ratio testing. Tests on the framework are verified using the chi-squared test, and only if the results are statistically significant are they deemed reliable and used to revise the software code. After the inception of Fishtest, Stockfish gained 120 Elo points in 12 months, propelling it to the top of all major rating lists. As of May 2026, the framework has used a total of more than 20,100 years of CPU time to play over 10 billion chess games. === NNUE === In June 2020, Stockfish introduced the efficiently updatable neural network (NNUE) approach, based on earlier work by computer shogi programmers. Instead of using manually designed heuristics to evaluate the board, this approach introduced a neural network trained on millions of positions which could be evaluated quickly on CPU. On 2 September 2020, the twelfth version of Stockfish was released, incorporating NNUE, and reportedly winning ten times more game pairs than it loses when matched against version eleven. In July 2023, the classical evaluation was completely removed in favor of the NNUE evaluation. == Competition results == === Top Chess Engine Championship === Stockfish is a TCEC multiple-time champion and the current leader in trophy count. Ever since TCEC restarted in 2013, Stockfish has finished first or second in every season except one. Stockfish finished second in TCEC Season 4 and 5, with scores of 23–25 first against Houdini 3 and later against Komodo 1142 in the Superfinal event. Season 5 was notable for the winning Komodo team as they accepted the award posthumously for the program's creator Don Dailey, who succumbed to an illness during the final stage of the event. In his honor, the version of Stockfish that was released shortly after that season was named "Stockfish DD". On 30 May 2014, Stockfish 170514 (a development version of Stockfish 5 with tablebase support) convincingly won TCEC Season 6, scoring 35.5–28.5 against Komodo 7x in the Superfinal. Stockfish 5 was released the following day. In TCEC Season 7, Stockfish again made the Superfinal, but lost to Komodo with a score of 30.5–33.5. In TCEC Season 8, despite losses on time caused by buggy code, Stockfish nevertheless qualified once more for the Superfinal, but lost 46.5–53.5 to Komodo. In Season 9, Stockfish defeated Houdini 5 with a score of 54.5–45.5. Stockfish finished third during season 10 of TCEC, the only season since 2013 in which Stockfish had failed to qualify for the superfinal. It did not lose a game but was still eliminated because it was unable to score enough wins against lower-rated engines. After this technical elimination, Stockfish went on a long winning streak, winning seasons 11 (59–41 against Houdini 6.03), 12 (60–40 against Komodo 12.1.1), and 13 (55–45 against Komodo 2155.00) convincingly. In Season 14, Stockfish faced a new challenger in Leela Chess Zero, eking out a win by one point (50.5–49.5). Its winning streak was finally ended in Season 15, when Leela qualified again and won 53.5–46.5, but Stockfish promptly won Season 16, defeating AllieStein 54.5–45.5, after Leela failed to qualify for the Superfinal. In Season 17, Stockfish faced Leela again in the superfinal, losing 52.5–47.5. However, Stockfish has won every Superfinal since: beating Leela 53.5–46.5 in Season 18, 54.5–45.5 in Season 19, 53–47 in Season 20, and 56–44 in Season 21. In Season 22, Komodo Dragon beat out Leela to qualify for the Superfinal, losing to Stockfish by a large margin 59.5–40.5. Stockfish did not lose an opening pair in this match. Leela made the Superfinal in Seasons 23 and 24, but was crushed by Stockfish both times (58.5–41.5 and 58–42). In Season 25, Stockfish once again defeated Leela, but this time by a narrower margin of 52–48. Stockfish also took part in the TCEC cup, winning the first edition, but was surprisingly upset by Houdini in the semifinals of the second edition. Stockfish recovered to beat Komodo in the third-place playoff. In the third edition, Stockfish made it to the finals, but was defeated by Leela Chess Zero after blundering in a 7-man endgame tablebase draw. It turned this result around in the fourth edition, defeating Leela in the final 4.5–3.5. In TCEC Cup 6, Stockfish finished third after losing to AllieStein in the semifinals, the first time it had failed to make the finals. Since then, Stockfish has consistently won the tournament, with the exception of the 11th edition which Leela won 8.5–7.5. === Chess.com Computer Chess Championship === Ever since Chess.com hosted its first Chess.com Computer Chess Championship in 2018, Stockfish has been the most successful engine. It dominated the earlier championships, winning six consecutive titles before finishing second in CCC7. Since then, its dominance has come under threat from the neural-network engines Leelenstein and Leela Chess Zero, but it has continued to perform w
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Mistral AI

Mistral AI SAS (French: [mistʁal]) is a French artificial intelligence (AI) company, headquartered in Paris. Founded in 2023, it has open-weight large language models (LLMs), with both open-source and proprietary AI models. As of 2025 the company has a valuation of more than US$14 billion. == Namesake == The company is named after the mistral, a powerful, cold wind in southern France, a term which originates from the Occitan language. == History == Mistral AI was established in April 2023 by three French AI researchers, Arthur Mensch, Guillaume Lample and Timothée Lacroix. Mensch, an expert in advanced AI systems, is a former employee of Google DeepMind; Lample and Lacroix, meanwhile, are large-scale AI models specialists who had worked for Meta Platforms. The trio originally met during their studies at École Polytechnique. == Company operation == === Funding === In June 2023, the start-up carried out a first fundraising of €105 million ($117 million) with investors including the American fund Lightspeed Venture Partners, Eric Schmidt, Xavier Niel and JCDecaux. The valuation was then estimated by the Financial Times at €240 million ($267 million). On 10 December 2023, Mistral AI announced that it had raised €385 million ($428 million) as part of its second fundraising. This round of financing involves the Californian fund Andreessen Horowitz, BNP Paribas and the software publisher Salesforce. It was valued at over €2 billion. On 26 February 2024, Microsoft announced an investment of $16 million in Mistral AI. On 16 April 2024, reporting revealed that Mistral was in talks to raise €500 million, a deal that would more than double its current valuation to at least €5 billion. In June 2024, Mistral AI secured a €600 million ($645 million) funding round, increasing its valuation to €5.8 billion ($6.2 billion). Based on valuation, as of June 2024, the company was ranked fourth globally in the AI industry, and first outside the San Francisco Bay Area. In April 2025, Mistral AI announced a €100 million partnership with the shipping company CMA CGM. In August 2025, the Financial Times reported that Mistral was in talks to raise $1 billion at a $10 billion valuation. In September 2025, Bloomberg announced that Mistral AI has secured a €2 billion investment valuing it at €12 billion ($14 billion). This comes after $1.5 billion investment from Dutch company ASML, which owns 11% of Mistral. In February 2026, Mistral acquired Koyeb, a Paris-based AI startup. Later that month, Mistral AI announced a multi-year strategic partnership with Accenture to help enterprises deploy sovereign AI solutions at scale. In March 2026 Mistral raised $830 million in order to build new datacenters near Paris and in Sweden. == Services == On 19 November, 2024, the company announced updates for Le Chat (pronounced /lə ʃa/ in French, like the French word for "cat"). It added the ability to create images, using Black Forest Labs' Flux Pro model. On 6 February 2025, Mistral AI released Le Chat on iOS and Android mobile devices. Mistral AI also introduced a Pro subscription tier, priced at $14.99 per month, which provides access to more advanced models, unlimited messaging, and web browsing. At the end of May 2026, Le Chat was renamed Vibe, and new features were introduced at the same time. == Models == The following table lists the main model versions of Mistral, describing the significant changes included with each version: === Mistral 7B === Mistral AI claimed in the Mistral 7B release blog post that the model outperforms LLaMA 2 13B on all benchmarks tested, and is on par with LLaMA 34B on many benchmarks tested, despite having only 7 billion parameters, a small size compared to its competitors. === Mixtral 8x7B === Mistral AI claimed in 2023 that its model beat both LLaMA 70B, and GPT-3.5 in most benchmarks. In March 2024, research conducted by Patronus AI comparing performance of LLMs on a 100-question test with prompts to generate text from books protected under U.S. copyright law found that OpenAI's GPT-4, Mixtral, Meta AI's LLaMA-2, and Anthropic's Claude 2 generated copyrighted text verbatim in 44%, 22%, 10%, and 8% of responses respectively. === Mistral Small 3.1 === On 17 March 2025, Mistral released Mistral Small 3.1 as a smaller, more efficient model. === Mistral Medium 3 === On 7 May 2025, Mistral AI released Mistral Medium 3. === Magistral Small and Magistral Medium === On 10 June 2025, Mistral AI released their first AI reasoning models: Magistral Small (open-source), and Magistral Medium, models which are purported to have chain-of-thought capabilities. === Mistral Large 3 and Ministral 3 === On 2 December 2025, Mistral AI released Mistral Large 3, a sparse, mixture-of-experts model with 41 billion active parameters and 675 billion total parameters, and Ministral 3, three small, dense models with 3 billion, 7 billion and 14 billion parameters. === Devstral 2 and Devstral Small 2 === On 10 December 2025, Mistral AI released Devstral 2 and Devstral Small 2. Devstral Small 2, a 24B parameter model is claimed to achieve better performance at coding than Qwen 3 Coder Flash model which is a 30B parameter model.
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Voyages: The Trans-Atlantic Slave Trade Database

Voyages: The Trans-Atlantic Slave Trade Database is a database hosted at Rice University that aims to present all documentary material pertaining to the transatlantic slave trade. It is a sister project to African Origins. The database breaks down the kingdoms and countries that engaged in the Atlantic trade. By 2008, the project had gathered data on nearly 35,000 transatlantic slave voyages from 1501 to 1867. For each voyage they sought to establish dates, owners, vessels, captains, African visits, American destinations, numbers of slaves embarked, and numbers landed. They have been able to find much of this material for an estimated 80 percent of the entire transatlantic African slave trade. With corrections for missing voyages, the Project has estimated the entire size of the transatlantic slave trade with more comprehension, precision, and accuracy than before. They reckon that in 366 years, slaving vessels embarked about 12.5 million captives in Africa, and landed 10.7 million in the New World. A horrific discovery is a careful estimate that the Middle Passage took a toll of more than 1.8 million African lives. In this quantitative database, the numbers are enslaved people.
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Minimum intelligent signal test

The minimum intelligent signal test, or MIST, is a variation of the Turing test proposed by Chris McKinstry in which only boolean (yes/no or true/false) answers may be given to questions. The purpose of such a test is to provide a quantitative statistical measure of humanness, which may subsequently be used to optimize the performance of artificial intelligence systems intended to imitate human responses. McKinstry gathered approximately 80,000 propositions that could be answered yes or no, e.g.: Is Earth a planet? Was Abraham Lincoln once President of the United States? Is the sun bigger than my foot? Do people sometimes lie? He called these propositions Mindpixels. These questions test both specific knowledge of aspects of culture, and basic facts about the meaning of various words and concepts. It could therefore be compared with the SAT, intelligence testing and other controversial measures of mental ability. McKinstry's aim was not to distinguish between shades of intelligence but to identify whether a computer program could be considered intelligent at all. According to McKinstry, a program able to do much better than chance on a large number of MIST questions would be judged to have some level of intelligence and understanding. For example, on a 20-question test, if a program were guessing the answers at random, it could be expected to score 10 correct on average. But the probability of a program scoring 20 out of 20 correct by guesswork is only one in 220, i.e. one in 1,048,576; so if a program were able to sustain this level of performance over several independent trials, with no prior access to the propositions, it should be considered intelligent. == Discussion == McKinstry criticized existing approaches to artificial intelligence such as chatterbots, saying that his questions could "kill" AI programs by quickly exposing their weaknesses. He contrasted his approach, a series of direct questions assessing an AI's capabilities, to the Turing test and Loebner Prize method of engaging an AI in undirected typed conversation. Critics of the MIST have noted that it would be easy to "kill" a McKinstry-style AI too, due to the impossibility of supplying it with correct answers to all possible yes/no questions by ways of a finite set of human-generated Mindpixels: the fact that an AI can answer the question "Is the sun bigger than my foot?" correctly does not mean that it can answer variations like "Is the sun bigger than (my hand | my liver | an egg yolk | Alpha Centauri A | ...)" correctly, too. However, the late McKinstry might have replied that a truly intelligent, knowledgeable entity (on a par with humans) would be able to work out answers such as (yes | yes | yes | don't know | ...) by applying its knowledge of the relative sizes of the objects named. In other words, the MIST was intended as a test of AI, not as a suggestion for implementing AI. It can also be argued that the MIST is a more objective test of intelligence than the Turing test, a subjective assessment that some might consider to be more a measure of the interrogator's gullibility than of the machine's intelligence. According to this argument, a human's judgment of a Turing test is vulnerable to the ELIZA effect, a tendency to mistake superficial signs of intelligence for the real thing, anthropomorphizing the program. The response, suggested by Alan Turing's essay Computing Machinery and Intelligence, is that if a program is a convincing imitation of an intelligent being, it is in fact intelligent. The dispute is thus over what it means for a program to have "real" intelligence, and by what signs it can be detected. A similar debate exists in the controversy over great ape language, in which nonhuman primates are said to have learned some aspects of sign languages but the significance of this learning is disputed.
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Eline Van der Velden

Eline van der Velden is a Dutch comedian, writer, actress and producer based in London, England. She is best known for her work creating Tilly Norwood, an AI-generated "actress". == Early life == Van der Velden was born on the Dutch island of Curaçao, Netherlands Antilles to Dutch businessman Steven van der Velden and physiotherapist Quirine van der Velden. She moved to the United Kingdom at age 14 to study drama and musical theatre at Tring Park School for the Performing Arts. She graduated with an MSc in physics from Imperial College London in 2008. == Career == She was nominated by the International Academy of Digital Arts and Sciences for the Lovie Awards and won Best Online Comedy in 2013 for two of her submitted entries. She has created multiple online shows such as Sketch My Life with London Hughes and Emily Hartridge and Match.com Parody. She became managing director of Makers Channel (makerschannel.co.uk), the first curated video platform in Europe in 2015. Makers Channel has been recently acquired by a Belgian media company De Persgroep, due to its success in the Netherlands. In 2016, she appeared in adverts for the Dutch shampoo brand Andrelon. Miss Holland, a comedy character created by Van der Velden, made headlines in 2016 as she asked the British public to teach her the national anthem. As an actress, she has starred in Dutch TV series De Troon, Beatrix and the Golden Calf-winning series Overspel. In Belgium, she appeared opposite Jamie Dornan in Flying Home. Van der Velden starred in the BBC Three series Putting It Out There, in which she challenges social perceptions of body hair, heels, spit, personal space, and authority figures. In 2018, she starred in the BBC One comedy series Soft Border Patrol and the BBC Three comedy series Miss Holland. In 2025, Particle6 Group, which Van der Velden founded in 2016, introduced Tilly Norwood, an AI-generated "actress" at the Zurich Film Festival. The announcement was met with outrage and a condemnation by the American actors' union SAG-AFTRA. == Awards and recognition == Miss Holland won the Best Online Comedy at the 2013 Lovie Awards, judged by Stephen Fry. The Match.com Parody video won Best Online Comedy People's Lovie Award, the people's vote. Miss Holland and Match.com Parody Date 1 were also featured in the 2013 Google Lovie Letters.
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LG ThinQ

LG ThinQ (pronounced as "think-cue"; sometimes known as LG webOS) is a smart home and artificial intelligence brand launched by LG Electronics in 2017, featuring products that are equipped with voice control and artificial intelligence technology. The brand was originally launched for home appliances and consumer electronics, such as televisions, smart home devices, mobile devices, refrigerators, air conditioners and related services. The name was first used in 2011 for LG's THINQ-branded smart appliances, which were introduced at the Consumer Electronics Show in Las Vegas. In December 2017, LG announced ThinQ as a unified brand for artificial intelligence-enabled home appliances, consumer electronics and services.In February 2018, LG announced the LG V30S ThinQ, which is the first phone to have the "ThinQ" branding. == History == The branding was first introduced in 2011 in the Consumer Electronics Show (CES) in Las Vegas as THINQ. The first ThinQ product was a smart refrigerator, with features such as smart savings options, food management system, washing machine, oven and robotic vacuum cleaner and different software in the LCD screen on the fridge. The unified branding was then officially launched as ThinQ at CES 2017 as an artificial intelligence-based brand for all their smart products. The company announced DeepThinQ, a deep-learning technology for connected products, and later opened an Artificial Intelligence Lab in Seoul to coordinate research involving voice, video, sensors and machine learning. In December 2017, LG announced ThinQ as a brand designation for home appliances, consumer electronics, and services incorporating artificial intelligence, applied to its 2018 product lineup. In 2018, LG extended the ThinQ brand to smartphones with the LG V30S ThinQ. The phone used ThinQ branding for AI camera features, including image recognition and shooting-mode recommendations. That year, LG also used ThinQ branding on televisions with smart-assistant features, as manufacturers increasingly added voice assistants to TV platforms. In 2022, LG first introduced ThinQ UP, a software-upgradable appliance concept that allows compatible appliances to receive new features through the ThinQ app. The program included appliances such as refrigerators, washing machines, dryers, ovens and dishwashers, and was covered as part of a wider move toward upgradeable connected appliances. In 2024, LG introduced ThinQ ON, an AI-powered smart home hub designed to connect LG appliances and other smart home devices. It expanded ThinQ from an appliance-control platform into a broader smart home system. == Platform an app == LG ThinQ operates as a smart home platform and mobile app for connecting compatible LG appliances and consumer electronics. The app is used to control and monitor supported products, including kitchen appliances, laundry appliances, air purifiers, vacuum cleaners and televisions. Depending on the product and market, the ThinQ app can provide remote control, status monitoring, downloadable appliance cycles, diagnostic support, maintenance alerts and software-based feature updates. In 2024, LG introduced ThinQ ON as a hub for the ThinQ platform. The device supports Matter, Thread and Wi-Fi connectivity and includes a built-in voice assistant. The Verge described the product as part of LG's effort to expand ThinQ from an appliance-control platform into a broader smart home system competing with platforms such as Samsung SmartThings and Apple Home. == Features == LG ThinQ products use connected-device features, voice control to interact with users, and use sensor data and different features such as product recognition and learning engine technologies to enhance their abilities. Deep ThinQ (or LG ThinQ AI) was introduced as LG's own AI platform. It was reported that it could engage in two-way conversations with users and could educate itself according to users' behaviour patterns and habits. At the 2017 ThinQ launch, LG said the brand would cover products and services using artificial intelligence technologies from LG and partner companies. ThinQ features vary by product category. On appliances, the platform may support remote operation, product-status notifications, downloaded cycles and diagnostic functions. On televisions, ThinQ branding has been associated with voice-control and smart-assistant features. In 2018, LG ThinQ-branded TVs added support for Google Assistant and Alexa voice commands. As of August 30, 2018, LG's ThinQ products now communicate with each other for tasks such as going to an event or following a recipe. They have sensors for communicating with other ThinQ devices and appliances. == Products == LG ThinQ branding and connectivity features have been used across several LG product categories, including home appliances, televisions, air conditioners and mobile devices. Home appliances LG has applied ThinQ branding and app connectivity to home appliances such as refrigerators, washing machines, dryers, dishwashers, cooking appliances, air purifiers and vacuum cleaners. Through the ThinQ app, compatible appliances can be monitored or controlled remotely. Some compatible appliances can also receive downloadable cycles, diagnostic support, maintenance alerts and software-based feature updates through ThinQ UP. Televisions and home entertainment LG has used ThinQ branding on smart televisions and other home entertainment products. In 2018, LG ThinQ-branded televisions added support for smart-assistant voice commands, including Google Assistant. Smartphones LG G6 (ThinQ branding was added to startup screen in an update) LG V30 (ThinQ branding was added to startup screen in an update) LG V30S ThinQ LG V35 ThinQ LG G7 ThinQ LG V40 ThinQ LG G8 ThinQ LG G8s ThinQ LG G8x ThinQ LG V50 ThinQ LG V60 ThinQ LG Velvet (Generally considered a ThinQ product in other countries)
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Computer audition

Computer audition (CA) or machine listening is the general field of study of algorithms and systems for audio interpretation by machines. Since the notion of what it means for a machine to "hear" is very broad and somewhat vague, computer audition attempts to bring together several disciplines that originally dealt with specific problems or had a concrete application in mind. The engineer Paris Smaragdis, interviewed in Technology Review, talks about these systems — "software that uses sound to locate people moving through rooms, monitor machinery for impending breakdowns, or activate traffic cameras to record accidents." Inspired by models of human audition, CA deals with questions of representation, transduction, grouping, use of musical knowledge and general sound semantics for the purpose of performing intelligent operations on audio and music signals by the computer. Technically this requires a combination of methods from the fields of signal processing, auditory modelling, music perception and cognition, pattern recognition, and machine learning, as well as more traditional methods of artificial intelligence for musical knowledge representation. == Applications == Like computer vision versus image processing, computer audition versus audio engineering deals with understanding of audio rather than processing. It also differs from problems of speech understanding by machine since it deals with general audio signals, such as natural sounds and musical recordings. Applications of computer audition are widely varying, and include search for sounds, genre recognition, acoustic monitoring, music transcription, score following, audio texture, music improvisation, emotion in audio and so on. == Related disciplines == Computer Audition overlaps with the following disciplines: Music information retrieval: methods for search and analysis of similarity between music signals. Auditory scene analysis: understanding and description of audio sources and events. Computational musicology and mathematical music theory: use of algorithms that employ musical knowledge for analysis of music data. Computer music: use of computers in creative musical applications. Machine musicianship: audition driven interactive music systems. == Areas of study == Since audio signals are interpreted by the human ear–brain system, that complex perceptual mechanism should be simulated somehow in software for "machine listening". In other words, to perform on par with humans, the computer should hear and understand audio content much as humans do. Analyzing audio accurately involves several fields: electrical engineering (spectrum analysis, filtering, and audio transforms); artificial intelligence (machine learning and sound classification); psychoacoustics (sound perception); cognitive sciences (neuroscience and artificial intelligence); acoustics (physics of sound production); and music (harmony, rhythm, and timbre). Furthermore, audio transformations such as pitch shifting, time stretching, and sound object filtering, should be perceptually and musically meaningful. For best results, these transformations require perceptual understanding of spectral models, high-level feature extraction, and sound analysis/synthesis. Finally, structuring and coding the content of an audio file (sound and metadata) could benefit from efficient compression schemes, which discard inaudible information in the sound. Computational models of music and sound perception and cognition can lead to a more meaningful representation, a more intuitive digital manipulation and generation of sound and music in musical human-machine interfaces. The study of CA could be roughly divided into the following sub-problems: Representation: signal and symbolic. This aspect deals with time-frequency representations, both in terms of notes and spectral models, including pattern playback and audio texture. Feature extraction: sound descriptors, segmentation, onset, pitch and envelope detection, chroma, and auditory representations. Musical knowledge structures: analysis of tonality, rhythm, and harmonies. Sound similarity: methods for comparison between sounds, sound identification, novelty detection, segmentation, and clustering. Sequence modeling: matching and alignment between signals and note sequences. Source separation: methods of grouping of simultaneous sounds, such as multiple pitch detection and time-frequency clustering methods. Auditory cognition: modeling of emotions, anticipation and familiarity, auditory surprise, and analysis of musical structure. Multi-modal analysis: finding correspondences between textual, visual, and audio signals. === Representation issues === Computer audition deals with audio signals that can be represented in a variety of fashions, from direct encoding of digital audio in two or more channels to symbolically represented synthesis instructions. Audio signals are usually represented in terms of analogue or digital recordings. Digital recordings are samples of acoustic waveform or parameters of audio compression algorithms. One of the unique properties of musical signals is that they often combine different types of representations, such as graphical scores and sequences of performance actions that are encoded as MIDI files. Since audio signals usually comprise multiple sound sources, then unlike speech signals that can be efficiently described in terms of specific models (such as source-filter model), it is hard to devise a parametric representation for general audio. Parametric audio representations usually use filter banks or sinusoidal models to capture multiple sound parameters, sometimes increasing the representation size in order to capture internal structure in the signal. Additional types of data that are relevant for computer audition are textual descriptions of audio contents, such as annotations, reviews, and visual information in the case of audio-visual recordings. === Features === Description of contents of general audio signals usually requires extraction of features that capture specific aspects of the audio signal. Generally speaking, one could divide the features into signal or mathematical descriptors such as energy, description of spectral shape etc., statistical characterization such as change or novelty detection, special representations that are better adapted to the nature of musical signals or the auditory system, such as logarithmic growth of sensitivity (bandwidth) in frequency or octave invariance (chroma). Since parametric models in audio usually require very many parameters, the features are used to summarize properties of multiple parameters in a more compact or salient representation. === Musical knowledge === Finding specific musical structures is possible by using musical knowledge as well as supervised and unsupervised machine learning methods. Examples of this include detection of tonality according to distribution of frequencies that correspond to patterns of occurrence of notes in musical scales, distribution of note onset times for detection of beat structure, distribution of energies in different frequencies to detect musical chords and so on. === Sound similarity and sequence modeling === Comparison of sounds can be done by comparison of features with or without reference to time. In some cases an overall similarity can be assessed by close values of features between two sounds. In other cases when temporal structure is important, methods of dynamic time warping need to be applied to "correct" for different temporal scales of acoustic events. Finding repetitions and similar sub-sequences of sonic events is important for tasks such as texture synthesis and machine improvisation. === Source separation === Since one of the basic characteristics of general audio is that it comprises multiple simultaneously sounding sources, such as multiple musical instruments, people talking, machine noises or animal vocalization, the ability to identify and separate individual sources is very desirable. Unfortunately, there are no methods that can solve this problem in a robust fashion. Existing methods of source separation rely sometimes on correlation between different audio channels in multi-channel recordings. The ability to separate sources from stereo signals requires different techniques than those usually applied in communications where multiple sensors are available. Other source separation methods rely on training or clustering of features in mono recording, such as tracking harmonically related partials for multiple pitch detection. Some methods, before explicit recognition, rely on revealing structures in data without knowing the structures (like recognizing objects in abstract pictures without attributing them meaningful labels) by finding the least complex data representations, for instance describing audio scenes as generated by a few tone patterns and their trajectories (polyphonic voices) and acoustical contours drawn by a tone (c
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ICAD (software)

ICAD (Corporate history: ICAD, Inc., Concentra (name change at IPO in 1995), KTI (name change in 1998), Dassault Systèmes (purchase in 2001) () is a knowledge-based engineering (KBE) system that enables users to encode design knowledge using a semantic representation that can be evaluated for Parasolid output. ICAD has an open architecture that can utilize all the power and flexibility of the underlying language. KBE, as implemented via ICAD, received a lot of attention due to the remarkable results that appeared to take little effort. ICAD allowed one example of end-user computing that in a sense is unparalleled. Most ICAD developers were degreed engineers. Systems developed by ICAD users were non-trivial and consisted of highly complicated code. In the sense of end-user computing, ICAD was the first to allow the power of a domain tool to be in the hands of the user, at the same time being open to allow extensions as identified and defined by the domain expert or subject-matter expert (SME). A COE article looked at the resulting explosion of expectations (see AI winter), which were not sustainable. However, such a bubble burst does not diminish the existence of ability that would exist were expectations and use reasonable or properly managed. == History == The original implementation of ICAD was on a Lisp machine (Symbolics). Some of the principals involved with the development were Larry Rosenfeld, Avrum Belzer, Patrick M. O'Keefe, Philip Greenspun, and David F. Place. The time frame was 1984–85. ICAD started on special-purpose Symbolics Lisp hardware and was then ported to Unix when Common Lisp became portable to general-purpose workstations. The original domain for ICAD was mechanical design with many application successes. However, ICAD has found use in other domains, such as electrical design, shape modeling, etc. An example project could be wind tunnel design or the development of a support tool for aircraft multidisciplinary design. Further examples can be found in the presentations at the annual IIUG (International ICAD Users Group) that have been published in the KTI Vault (1999 through 2002). Boeing and Airbus used ICAD extensively to develop various components in the 1990s and early 21st century. As of 2003, ICAD was featured strongly in several areas as evidenced by the Vision & Strategy Product Vision and Strategy presentation. After 2003, ICAD use diminished. At the end of 2001, the KTI Company faced financial difficulties and laid off most of its best staff. They were eventually bought out by Dassault who effectively scuppered the ICAD product. See IIUG at COE, 2003 (first meeting due to Dassault by KTI) The ICAD system was very expensive, relatively, and was in the price range of high-end systems. Market dynamics couldn't support this as there may not have been sufficient differentiating factors between ICAD and the lower-end systems (or the promises from Dassault). KTI was absorbed by Dassault Systèmes and ICAD is no longer considered the go-forward tool for knowledge-based engineering (KBE) applications by that company. Dassault Systèmes is promoting a suite of tools oriented around version 5 of their popular CATIA CAD application, with Knowledgeware the replacement for ICAD. As of 2005, things were still a bit unclear. ICAD 8.3 was delivered. The recent COE Aerospace Conference had a discussion about the futures of KBE. One issue involves the stacking of 'meta' issues within a computer model. How this is resolved, whether by more icons or the availability of an external language, remains to be seen. The Genworks GDL product (including kernel technology from the Gendl Project) is the nearest functional equivalent to ICAD currently available. == Particulars == ICAD provided a declarative language (IDL) using New Flavors (never converted to Common Lisp Object System (CLOS)) that supported a mechanism for relating parts (defpart) via a hierarchical set of relationships. Technically, the ICAD Defpart was a Lisp macro; the ICAD defpart list was a set of generic classes that can be instantiated with specific properties depending upon what was represented. This defpart list was extendible via composited parts that represented domain entities. Along with the part-subpart relations, ICAD supported generic relations via the object modeling abilities of Lisp. Example applications of ICAD range from a small collection of defparts that represents a part or component to a larger collection that represents an assembly. In terms of power, an ICAD system, when fully specified, can generate thousands of instances of parts on a major assembly design. One example of an application driving thousands of instances of parts is that of an aircraft wing – where fastener type and placement may number in the thousands, each instance requiring evaluation of several factors driving the design parameters. == Futures (KBE, etc.) == One role for ICAD may be serving as the defining prototype for KBE which would require that we know more about what occurred the past 15 years (much information is tied up behind corporate firewalls and under proprietary walls). With the rise of functional programming languages (an example is Haskell) in the markets, perhaps some of the power attributable to Lisp may be replicated.
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AlphaFold

AlphaFold is an artificial intelligence (AI) program developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure. It is designed using deep learning techniques. AlphaFold 1 (2018) placed first in the overall rankings of the 13th Critical Assessment of Structure Prediction (CASP) in December 2018. It was particularly successful at predicting the most accurate structures for targets rated as most difficult by the competition organizers, where no existing template structures were available from proteins with partially similar sequences. AlphaFold 2 (2020) repeated this placement in the CASP14 competition in November 2020. It achieved a level of accuracy much higher than any other entry. It scored above 90 on CASP's global distance test (GDT) for approximately two-thirds of the proteins, a test measuring the similarity between a computationally predicted structure and the experimentally determined structure, where 100 represents a complete match. The inclusion of metagenomic data has improved the quality of the prediction of multiple sequence alignments. One of the biggest sources of the training data was the custom-built Big Fantastic Database of 65,983,866 protein families, represented as multiple sequence alignments and Hidden Markov models, covering 2,204,359,010 protein sequences from reference databases, metagenomes, and metatranscriptomes. AlphaFold 2's results at CASP14 were described as "astounding" and "transformational". However, some researchers noted that the accuracy was insufficient for a third of its predictions, and that it did not reveal the underlying mechanism or rules of protein folding for the protein folding problem, which remains unsolved. Despite this, the technical achievement was widely recognized. On 15 July 2021, the AlphaFold 2 paper was published in Nature as an advance access publication alongside open source software and a searchable database of species proteomes. As of November 2025, the paper had been cited nearly 43,000 times. AlphaFold 3 was announced on 8 May 2024. It can predict the structure of complexes created by proteins with DNA, RNA, various ligands, and ions. The new prediction method shows a minimum 50% improvement in accuracy for protein interactions with other molecules compared to existing methods. Demis Hassabis and John Jumper shared one half of the 2024 Nobel Prize in Chemistry, awarded "for protein structure prediction," while the other half went to David Baker "for computational protein design." Hassabis and Jumper had previously won the Breakthrough Prize in Life Sciences and the Albert Lasker Award for Basic Medical Research in 2023 for their leadership of the AlphaFold project. == Background == Proteins consist of chains of amino acids which spontaneously fold to form the three dimensional (3-D) structures of the proteins. The 3-D structure is crucial to understanding the biological function of the protein. Protein structures can be determined experimentally through techniques such as X-ray crystallography, cryo-electron microscopy and nuclear magnetic resonance (NMR), which are all expensive and time-consuming. Such efforts, using the experimental methods, have identified the structures of about 170,000 proteins over the last 60 years, while there are over 200 million known proteins across all life forms. Over the years, researchers have applied numerous computational methods to predict the 3D structures of proteins from their amino acid sequences, accuracy of such methods in best possible scenario is close to experimental techniques (NMR) by the use of homology modeling based on molecular evolution. CASP, which was launched in 1994 to challenge the scientific community to produce their best protein structure predictions, found that GDT scores of only about 40 out of 100 can be achieved for the most difficult proteins by 2016. AlphaFold started competing in the 2018 CASP using an artificial intelligence (AI) deep learning technique. == Algorithm == DeepMind is known to have trained the program on over 170,000 protein structures from the Protein Data Bank, a public repository of protein sequences and structures. The program uses a form of attention network, a deep learning technique that focuses on having the AI identify parts of a larger problem, then piece it together to obtain the overall solution. The overall training was conducted on processing power between 100 and 200 GPUs. === AlphaFold 1 (2018) === AlphaFold 1 (2018) was built on work developed by various teams in the 2010s, work that looked at the large databases of related protein sequences now available from many different organisms (most without known 3D structures), to try to find changes at different residues (peptides) that appeared to be correlated, even though the residues were not consecutive in the main chain. Such correlations suggest that the residues may be close to each other physically, even though not close in the sequence, allowing a contact map to be estimated. Building on recent work prior to 2018, AlphaFold 1 extended this by estimating a probability distribution for the distances between residues, effectively transforming the contact map into a distance map. It also used more advanced learning methods than previously to develop the inference. The code was not made publicly available, except to run on sequences of proteins in the 2018 CASP competition. === AlphaFold 2 (2020) === The 2020 version of the program (AlphaFold 2, 2020) is significantly different from the original version that won CASP 13 in 2018, according to the team at DeepMind. AlphaFold 1 used a number of separately trained modules to produce a guide potential, which was then combined with a physics-based energy potential. AlphaFold 2 replaced this with a system of interconnected sub-networks, forming a single, differentiable, end-to-end model based on pattern recognition. This model was trained in an integrated manner. After the neural network's prediction converges, a final refinement step applies local physical constraints using energy minimization based on the AMBER force field. This step only slightly adjusts the predicted structure. A key part of the 2020 system are two modules, believed to be based on a transformer design, which are used to progressively refine a vector of information for each relationship (or "edge" in graph-theory terminology) between an amino acid residue of the protein and another amino acid residue (these relationships are represented by the array shown in green); and between each amino acid position and each different sequences in the input sequence alignment (these relationships are represented by the array shown in red). Internally these refinement transformations contain layers that have the effect of bringing relevant data together and filtering out irrelevant data (the "attention mechanism") for these relationships, in a context-dependent way, learned from training data. These transformations are iterated, the updated information output by one step becoming the input of the next, with the sharpened residue/residue information feeding into the update of the residue/sequence information, and then the improved residue/sequence information feeding into the update of the residue/residue information. As the iteration progresses, according to one report, the "attention algorithm ... mimics the way a person might assemble a jigsaw puzzle: first connecting pieces in small clumps—in this case clusters of amino acids—and then searching for ways to join the clumps in a larger whole." The output of these iterations then informs the final structure prediction module, which also uses transformers, and is itself then iterated. In an example presented by DeepMind, the structure prediction module achieved a correct topology for the target protein on its first iteration, scored as having a GDT_TS of 78, but with a large number (90%) of stereochemical violations – i.e. unphysical bond angles or lengths. With subsequent iterations the number of stereochemical violations fell. By the third iteration the GDT_TS of the prediction was approaching 90, and by the eighth iteration the number of stereochemical violations was approaching zero. The training data was originally restricted to single peptide chains. However, the October 2021 update, named AlphaFold-Multimer, included protein complexes in its training data. DeepMind stated this update succeeded about 70% of the time at accurately predicting protein-protein interactions. === AlphaFold 3 (2024) === Announced on 8 May 2024, AlphaFold 3 was co-developed by Google DeepMind and Isomorphic Labs, both subsidiaries of Alphabet. AlphaFold 3 is not limited to proteins, as it can also predict the structures of protein complexes with DNA, RNA, post-translational modifications and selected ligands and ions. AlphaFold 3 introduces the "Pairformer," a deep learning architecture inspired by the transformer, which is considered similar to, but si
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