AI Chatbot Robot

AI Chatbot Robot — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

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  Ultra Hal

  Ultra Hal is a chatbot intended to function as a virtual assistant. It was developed by Zabaware, Inc. Ultra Hal uses a natural language interface with animated characters using speech synthesis. Users can communicate with the chatterbot via typing or via a speech recognition engine. It utilizes the WordNet lexical dictionary. Its name is an allusion to HAL 9000, the artificial intelligence from the movie 2001: A Space Odyssey. Ultra Hal won the 2007 Loebner Prize for "most human" chatterbot.

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  Density-based clustering validation

  Density-Based Clustering Validation (DBCV) is a metric designed to assess the quality of clustering solutions, particularly for density-based clustering algorithms like DBSCAN, Mean shift, and OPTICS. This metric is particularly suited for identifying concave and nested clusters, where traditional metrics such as the Silhouette coefficient, Davies–Bouldin index, or Calinski–Harabasz index often struggle to provide meaningful evaluations. Unlike traditional validation measures, which often rely on compact and well-separated clusters, DBCV index evaluates how well clusters are defined in terms of local density variations and structural coherence. This metric was introduced in 2014 by David Moulavi and colleagues in their work. It utilizes density connectivity principles to quantify clustering structures, making it especially effective at detecting arbitrarily shaped clusters in concave datasets, where traditional metrics may be less reliable. The DBCV index has been employed for clustering analysis in bioinformatics, ecology, techno-economy, and health informatics , as well as in numerous other fields. == Definition == DBCV index evaluates clustering structures by analyzing the relationships between data points within and across clusters. Given a dataset X = x 1 , x 2 , . . . , x n {\displaystyle X={x_{1},x_{2},...,x_{n}}} , a density-based algorithm partitions it into K clusters C 1 , C 2 , . . . , C K {\displaystyle {C_{1},C_{2},...,C_{K}}} . Each point x i {\displaystyle x_{i}} belongs to a specific cluster, denoted as C c l u s t e r ( x i ) {\displaystyle C_{cluster(x_{i})}} A key concept in DBCV index is the notion of density-connected paths. Two points within the same cluster are considered density-connected if there exists a sequence of intermediate points linking them, where each consecutive pair meets a predefined density criterion. The density-based distance between two points is determined by identifying the optimal path that minimizes the maximum local reachability distance along its trajectory. DBCV index extends the Silhouette coefficient by redefining cluster cohesion and separation using density-based distances: Within-cluster density distance measures how closely a point is related to other members of its cluster: a i = 1 | C c l u s t e r ( x i ) | − 1 ∑ x j ∈ C c l u s t e r ( x i ) , y ≠ x d d e n s i t y ( x j , x i ) {\displaystyle a_{i}={\frac {1}{|C_{cluster(x_{i})}|-1}}\sum _{x_{j}\in C_{cluster(x_{i})},y\neq x}d_{density}(x_{j},x_{i})} Nearest-cluster density distance quantifies how far a point is from the closest external cluster: b i = min C ≠ C cluster ( x i ) C ∈ { C 1 , … , C K } ( 1 | C | ∑ x j ∈ C d density ( x i , x j ) ) . {\displaystyle b_{i}=\min _{C\neq C_{{\text{cluster}}(x_{i})} \atop C\in \{C_{1},\dots ,C_{K}\}}\left({\frac {1}{|C|}}\sum _{x_{j}\in C}d_{\text{density}}(x_{i},x_{j})\right).} Using these measures, the DBCV index is computed as: D B C V = 1 n ∑ i = 1 n b i − a i max ( a i , b i ) {\displaystyle DBCV={\frac {1}{n}}\sum _{i=1}^{n}{\frac {b_{i}-a_{i}}{\max(a_{i},b_{i})}}} == Explanation == DBCV index values range between −1 and +1: +1: Strongly cohesive and well-separated clusters. 0: Ambiguous clustering structure. −1: Poorly formed clusters or incorrect assignments. By leveraging density-based distances instead of traditional Euclidean measures, DBCV index provides a more robust evaluation of clustering performance in datasets with irregular or non-spherical distributions.

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  Charge based boundary element fast multipole method

  The charge-based formulation of the boundary element method (BEM) is a dimensionality reduction numerical technique that is used to model quasistatic electromagnetic phenomena in highly complex conducting media (targeting, e.g., the human brain) with a very large (up to approximately 1 billion) number of unknowns. The charge-based BEM solves an integral equation of the potential theory written in terms of the induced surface charge density. This formulation is naturally combined with fast multipole method (FMM) acceleration, and the entire method is known as charge-based BEM-FMM. The combination of BEM and FMM is a common technique in different areas of computational electromagnetics and, in the context of bioelectromagnetism, it provides improvements over the finite element method. == Historical development == Along with more common electric potential-based BEM, the quasistatic charge-based BEM, derived in terms of the single-layer (charge) density, for a single-compartment medium has been known in the potential theory since the beginning of the 20th century. For multi-compartment conducting media, the surface charge density formulation first appeared in discretized form (for faceted interfaces) in the 1964 paper by Gelernter and Swihart. A subsequent continuous form, including time-dependent and dielectric effects, appeared in the 1967 paper by Barnard, Duck, and Lynn. The charge-based BEM has also been formulated for conducting, dielectric, and magnetic media, and used in different applications. In 2009, Greengard et al. successfully applied the charge-based BEM with fast multipole acceleration to molecular electrostatics of dielectrics. A similar approach to realistic modeling of the human brain with multiple conducting compartments was first described by Makarov et al. in 2018. Along with this, the BEM-based multilevel fast multipole method has been widely used in radar and antenna studies at microwave frequencies as well as in acoustics. == Physical background - surface charges in biological media == The charge-based BEM is based on the concept of an impressed (or primary) electric field E i {\displaystyle \mathbf {E} ^{i}} and a secondary electric field E s {\displaystyle \mathbf {E} ^{s}} . The impressed field is usually known a priori or is trivial to find. For the human brain, the impressed electric field can be classified as one of the following: A conservative field E i {\displaystyle \mathbf {E} ^{i}} derived from an impressed density of EEG or MEG current sources in a homogeneous infinite medium with the conductivity σ {\displaystyle \sigma } at the source location; An instantaneous solenoidal field E i {\displaystyle \mathbf {E} ^{i}} of an induction coil obtained from Faraday's law of induction in a homogeneous infinite medium (air), when transcranial magnetic stimulation (TMS) problems are concerned; A surface field E i {\displaystyle \mathbf {E} ^{i}} derived from an impressed surface current density J i = σ E i {\displaystyle \mathbf {J} ^{i}=\sigma \mathbf {E} ^{i}} of current electrodes injecting electric current at a boundary of a compartment with conductivity σ {\displaystyle \sigma } when transcranial direct-current stimulation (tDCS) or deep brain stimulation (DBS) are concerned; A conservative field E i {\displaystyle \mathbf {E} ^{i}} of charges deposited on voltage electrodes for tDCS or DBS. This specific problem requires a coupled treatment since these charges will depend on the environment; In application to multiscale modeling, a field E i {\displaystyle \mathbf {E} ^{i}} obtained from any other macroscopic numerical solution in a small (mesoscale or microscale) spatial domain within the brain. For example, a constant field can be used. When the impressed field is "turned on", free charges located within a conducting volume D immediately begin to redistribute and accumulate at the boundaries (interfaces) of regions of different conductivity in D. A surface charge density ρ ( r ) {\displaystyle \rho (\mathbf {r} )} appears on the conductivity interfaces. This charge density induces a secondary conservative electric field E s {\displaystyle \mathbf {E} ^{s}} following Coulomb's law. One example is a human under a direct current powerline with the known field E i {\displaystyle \mathbf {E} ^{i}} directed down. The superior surface of the human's conducting body will be charged negatively while its inferior portion is charged positively. These surface charges create a secondary electric field that effectively cancels or blocks the primary field everywhere in the body so that no current will flow within the body under DC steady state conditions. Another example is a human head with electrodes attached. At any conductivity interface with a normal vector n {\displaystyle \mathbf {n} } pointing from an "inside" (-) compartment of conductivity σ − {\displaystyle \sigma ^{-}} to an "outside" (+) compartment of conductivity σ + {\displaystyle \sigma ^{+}} , Kirchhoff's current law requires continuity of the normal component of the electric current density. This leads to the interfacial boundary condition in the form for every facet at a triangulated interface. As long as σ ± {\displaystyle \sigma ^{\pm }} are different from each other, the two normal components of the electric field, E ± ⋅ n {\displaystyle \mathbf {E} ^{\pm }\cdot \mathbf {n} } , must also be different. Such a jump across the interface is only possible when a sheet of surface charge exists at that interface. Thus, if an electric current or voltage is applied, the surface charge density follows. The goal of the numerical analysis is to find the unknown surface charge distribution and thus the total electric field E = E i + E s {\displaystyle \mathbf {E} =\mathbf {E} ^{i}+\mathbf {E} ^{s}} (and the total electric potential if required) anywhere in space. == System of equations for surface charges == Below, a derivation is given based on Gauss's law and Coulomb's law. All conductivity interfaces, denoted by S, are discretized into planar triangular facets t m {\displaystyle t_{m}} with centers r m {\displaystyle \mathbf {r} _{m}} . Assume that an m-th facet with the normal vector n m {\displaystyle \mathbf {n} _{m}} and area A m {\displaystyle A_{m}} carries a uniform surface charge density ρ m {\displaystyle \rho _{m}} . If a volumetric tetrahedral mesh were present, the charged facets would belong to tetrahedra with different conductivity values. We first compute the electric field E m + {\displaystyle \mathbf {E} _{m}^{+}} at the point r m + δ n m {\displaystyle \mathbf {r} _{m}+\delta \mathbf {n} _{m}} , for δ → 0 + {\displaystyle \delta \rightarrow 0^{+}} i.e., just outside facet 𝑚 at its center. This field contains three contributions: The continuous impressed electric field E i {\displaystyle \mathbf {E} ^{i}} itself; An electric field of the m-th charged facet itself. Very close to the facet, it can be approximated as the electric field of an infinite sheet of uniform surface charge ρ m {\displaystyle \rho _{m}} . By Gauss's law, it is given by + ρ m / 2 ε 0 ⋅ n m {\displaystyle +\rho _{m}/2\varepsilon _{0}\cdot \mathbf {n} _{m}} where ε 0 {\displaystyle \varepsilon _{0}} is a background electrical permittivity; An electric field generated by all other facets t n {\displaystyle t_{n}} , which we approximate as point charges of charge A n ρ n {\displaystyle A_{n}\rho _{n}} at each center r n {\displaystyle \mathbf {r} _{n}} . A similar treatment holds for the electric field E m − {\displaystyle \mathbf {E} _{m}^{-}} just inside facet 𝑚, but the electric field of the flat sheet of charge changes its sign. Using Coulomb's law to calculate the contribution of facets different from t m {\displaystyle t_{m}} , we find From this equation, we see that the normal component of the electric field indeed undergoes a jump through the charged interface. This is equivalent to a jump relation of the potential theory. As a second step, the two expressions for E m ± {\displaystyle \mathbf {E} _{m}^{\pm }} are substituted into the interfacial boundary condition σ − E m − ⋅ n m = σ + E m + ⋅ n m {\displaystyle \sigma ^{-}\mathbf {E} _{m}^{-}\cdot \mathbf {n} _{m}=\sigma ^{+}\mathbf {E} _{m}^{+}\cdot \mathbf {n} _{m}} , applied to every facet 𝑚. This operation leads to a system of linear equations for unknown charge densities ρ m {\displaystyle \rho _{m}} which solves the problem: where K m = σ − − σ + σ − + σ + {\displaystyle K_{m}={\frac {\sigma ^{-}-\sigma ^{+}}{\sigma ^{-}+\sigma ^{+}}}} is the electric conductivity contrast at the m-th facet. The normalization constant ε 0 {\displaystyle \varepsilon _{0}} will cancel out after the solution is substituted in the expression for E s {\displaystyle \mathbf {E} ^{s}} and becomes redundant. == Application of fast multipole method == For modern characterizations of brain topologies with ever-increasing levels of complexity, the above system of equations for ρ m {\displaystyle \rho _{m}} is very large; it is t

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  Calibration (statistics)

  There are two main uses of the term calibration in statistics that denote special types of statistical inference problems. Calibration can mean a reverse process to regression, where instead of a future dependent variable being predicted from known explanatory variables, a known observation of the dependent variables is used to predict a corresponding explanatory variable; procedures in statistical classification to determine class membership probabilities which assess the uncertainty of a given new observation belonging to each of the already established classes. In addition, calibration is used in statistics with the usual general meaning of calibration. For example, model calibration can be also used to refer to Bayesian inference about the value of a model's parameters, given some data set, or more generally to any type of fitting of a statistical model. As Philip Dawid puts it, "a forecaster is well calibrated if, for example, of those events to which he assigns a probability 30 percent, the long-run proportion that actually occurs turns out to be 30 percent." == In classification == Calibration in classification means transforming classifier scores into class membership probabilities. An overview of calibration methods for two-class and multi-class classification tasks is given by Gebel (2009). A classifier might separate the classes well, but be poorly calibrated, meaning that the estimated class probabilities are far from the true class probabilities. In this case, a calibration step may help improve the estimated probabilities. A variety of metrics exist that are aimed to measure the extent to which a classifier produces well-calibrated probabilities. Foundational work includes the Expected Calibration Error (ECE). Into the 2020s, variants include the Adaptive Calibration Error (ACE) and the Test-based Calibration Error (TCE), which address limitations of the ECE metric that may arise when classifier scores concentrate on narrow subset of the [0,1] range. A 2020s advancement in calibration assessment is the introduction of the Estimated Calibration Index (ECI). The ECI extends the concepts of the Expected Calibration Error (ECE) to provide a more nuanced measure of a model's calibration, particularly addressing overconfidence and underconfidence tendencies. Originally formulated for binary settings, the ECI has been adapted for multiclass settings, offering both local and global insights into model calibration. This framework aims to overcome some of the theoretical and interpretative limitations of existing calibration metrics. Through a series of experiments, Famiglini et al. demonstrate the framework's effectiveness in delivering a more accurate understanding of model calibration levels and discuss strategies for mitigating biases in calibration assessment. An online tool has been proposed to compute both ECE and ECI. The following univariate calibration methods exist for transforming classifier scores into class membership probabilities in the two-class case: Assignment value approach, see Garczarek (2002) Bayes approach, see Bennett (2002) Isotonic regression, see Zadrozny and Elkan (2002) Platt scaling (a form of logistic regression), see Lewis and Gale (1994) and Platt (1999) Bayesian Binning into Quantiles (BBQ) calibration, see Naeini, Cooper, Hauskrecht (2015) Beta calibration, see Kull, Filho, Flach (2017) === In probability prediction and forecasting === In prediction and forecasting, a Brier score is sometimes used to assess prediction accuracy of a set of predictions, specifically that the magnitude of the assigned probabilities track the relative frequency of the observed outcomes. Philip E. Tetlock employs the term "calibration" in this sense in his 2015 book Superforecasting. This differs from accuracy and precision. For example, as expressed by Daniel Kahneman, "if you give all events that happen a probability of .6 and all the events that don't happen a probability of .4, your discrimination is perfect but your calibration is miserable". In meteorology, in particular, as concerns weather forecasting, a related mode of assessment is known as forecast skill. == In regression == The calibration problem in regression is the use of known data on the observed relationship between a dependent variable and an independent variable to make estimates of other values of the independent variable from new observations of the dependent variable. This can be known as "inverse regression"; there is also sliced inverse regression. The following multivariate calibration methods exist for transforming classifier scores into class membership probabilities in the case with classes count greater than two: Reduction to binary tasks and subsequent pairwise coupling, see Hastie and Tibshirani (1998) Dirichlet calibration, see Gebel (2009) === Example === One example is that of dating objects, using observable evidence such as tree rings for dendrochronology or carbon-14 for radiometric dating. The observation is caused by the age of the object being dated, rather than the reverse, and the aim is to use the method for estimating dates based on new observations. The problem is whether the model used for relating known ages with observations should aim to minimise the error in the observation, or minimise the error in the date. The two approaches will produce different results, and the difference will increase if the model is then used for extrapolation at some distance from the known results.

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  Amira (software)

  Amira (ah-MEER-ah) is a software platform for visualization, processing, and analysis of 3D and 4D data. It is being actively developed by Thermo Fisher Scientific in collaboration with the Zuse Institute Berlin (ZIB), and commercially distributed by Thermo Fisher Scientific — together with its sister software Avizo. == Overview == Amira is an extendable software system for scientific visualization, data analysis, and presentation of 3D and 4D data. It is used by researchers and engineers in academia and industry. It is a tool for processing, analysis and visualization of data from various modalities; e.g. micro-CT, PET, Ultrasound. It is used in many fields, such as microscopy in biology and materials science, molecular biology, quantum physics, astrophysics, computational fluid dynamics (CFD), finite element modeling (FEM), non-destructive testing (NDT), and many more. One of the key features, besides data visualization, is Amira's set of tools for image segmentation and geometry reconstruction. This allows the user to mark (or segment) structures and regions of interest in 3D image volumes using automatic, semi-automatic, and manual tools. The segmentation can then be used for a variety of subsequent tasks, such as volumetric analysis, density analysis, shape analysis, or the generation of 3D computer models for visualization, numerical simulations, or rapid prototyping or 3D printing. Other key Amira features are multi-planar and volume visualization, image registration, filament tracing, cell separation and analysis, tetrahedral mesh generation, fiber-tracking from diffusion tensor imaging (DTI) data, skeletonization, spatial graph analysis, and stereoscopic rendering of 3D data over multiple displays and immersive virtual reality environments, including CAVEs. As a commercial product Amira requires the purchase of a license or an academic subscription. A time-limited, but full-featured evaluation version is available for download free of charge. == History == === 1993–1998: Research software === Amira's roots go back to 1993 and the Department for Scientific Visualization, headed by Hans-Christian Hege at the Zuse Institute Berlin (ZIB). The ZIB is a research institute for mathematics and informatics. The Scientific Visualization department's mission is to help solve computationally and scientifically challenging tasks in medicine, biology, engineering and materials science. For this purpose, it develops algorithms and software for 2D, 3D, and 4D data visualization and visually supported exploration and analysis. At that time, the young visualization group at the ZIB had experience with the extendable, data flow-oriented visualization environments apE, IRIS Explorer, and Advanced Visualization Studio (AVS), but was not satisfied with these products' interactivity, flexibility, and ease-of-use for non-computer scientists. Therefore, the development of a new software system was started in a research project within a medically oriented, multi-disciplinary collaborative research center. Based on experiences that Tobias Höllerer had gained in late 1993 with the new graphics library IRIS Inventor, it was decided to utilize that library. The development of the medical planning system was performed by Detlev Stalling, who later became the chief software architect of Amira. The new software was called "HyperPlan", highlighting its initial target application – a planning system for hyperthermia cancer treatment. The system was being developed on Silicon Graphics (SGI) computers, which at the time were the standard workstations used for high-end graphics computing. The software was based on libraries such as OpenGL (originally IRIS GL), Open Inventor (originally IRIS Inventor), and the graphical user interface libraries X11, Motif (software), and ViewKit. In 1998, X11/Motif/Viewkit were replaced by the Qt toolkit. The HyperPlan framework served as the base for more and more projects at the ZIB and was used by a growing number of researchers in collaborating institutions. The projects included applications in medical image computing, medical visualization, neurobiology, confocal microscopy, flow visualization, molecular analytics and computational astrophysics. === 1998–today: Commercially supported product === The growing number of users of the system started to exceed the capacities that ZIB could spare for software distribution and support, as ZIB's primary mission was algorithmic research. Therefore, the spin-off company Indeed – Visual Concepts GmbH was founded by Hans-Christian Hege, Detlev Stalling, and Malte Westerhoff. In Feb 1998 the HyperPlan software was given the new, application-neutral name "Amira". This name is not an acronym, but was chosen for being pronounceable in different languages and providing a suitable connotation, namely "to look at" or "to wonder at", from the Latin verb "admirare" (to admire), which reflects a basic situation in data visualization. A major re-design of the software was undertaken by Detlev Stalling and Malte Westerhoff in order to make it a commercially supportable product and to make it available on non-SGI computers as well. In March 1999, the first version of the commercial Amira was exhibited at the CeBIT tradeshow in Hannover, Germany on SGI IRIX and Hewlett-Packard UniX (HP-UX) booths. Versions for Linux and Microsoft Windows followed within the following twelve months. Later Mac OS X support was added. Indeed – Visual Concepts GmbH selected the Bordeaux, France and San Diego, United States based company TGS, Inc. as the worldwide distributor for Amira and completed five major releases (up to version 3.1) in the subsequent four years. In 2003 both Indeed – Visual Concepts GmbH, as well as TGS, Inc. were acquired by Massachusetts-based Mercury Computer Systems, Inc. (NASDAQ:MRCY) and became part of Mercury's newly formed life sciences business unit, later branded Visage Imaging. In 2009, Mercury Computer Systems, Inc. spun off Visage Imaging again and sold it to Melbourne, Australia based Promedicus Ltd (ASX:PME), a leading provider of radiology information systems and medical IT solutions. During this time, Amira continued to be developed in Berlin, Germany and in close collaboration with the ZIB, still headed by the original creators of Amira. TGS, located in Bordeaux, France was sold by Mercury Computer systems to a French investor and renamed to Visualization Sciences Group (VSG). VSG continued the work on a complementary product named Avizo, based on the same source code but customized for material sciences. In August 2012, FEI, to that date the largest OEM reseller of Amira, purchased VSG and the Amira business from Promedicus. This brought the two software sisters Amira and Avizo back into one hand. In August 2013, Visualization Sciences Group (VSG) became a business unit of FEI. In 2016 FEI has been bought by Thermo Fisher Scientific and became part of its Materials & Structural Analysis division in early 2017. Amira and Avizo are still being marketed as two different products; Amira for life sciences and Avizo for materials science, but the development efforts are now joined once again. In the meantime, the number of scientific articles using the Amira / Avizo software, is in the order of 10 thousands. == Amira options == === Microscopy option === Specific readers for microscopy data Image deconvolution Exploration of 3D imagery obtained from virtually any microscope Extraction and editing of filament networks from microscopy images === DICOM reader === Import of clinical and preclinical data in DICOM format === Mesh option === Generation of 3D finite element (FE) meshes from segmented image data Support for many state-of-the-art FE solver formats High-quality visualization of simulation mesh-based results, using scalar, vector, and tensor field display modules === Skeletonization option === Reconstruction and analysis of neural and vascular networks Visualization of skeletonized networks Length and diameter quantification of network segments Ordering of segments in a tree graph Skeletonization of very large image stacks === Molecular option === Advanced tools for the visualization of molecule models Hardware-accelerated volume rendering Powerful molecule editor Specific tools for complex molecular visualization === Developer option === Creation of new custom components for visualizing or data processing Implementation of new file readers or writers C++ programming language Development wizard for getting started quickly === Neuro option === Medical image analysis for DTI and brain perfusion Fiber tracking supporting several stream-line based algorithms Fiber separation into fiber bundles based on user defined source and destination regions Computation of tensor fields, diffusion weighted maps Eigenvalue decomposition of tensor fields Computation of mean transit time, cerebral blood flow, and cerebral blood volume === VR option === Visualization of data on large tiled displays

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  Latent class model

  In statistics, a latent class model (LCM) is a model for clustering multivariate discrete data. It assumes that the data arise from a mixture of discrete distributions, within each of which the variables are independent. It is called a latent class model because the class to which each data point belongs is unobserved (or latent). Latent class analysis (LCA) is a subset of structural equation modeling used to find groups or subtypes of cases in multivariate categorical data. These groups or subtypes of cases are called "latent classes". When faced with the following situation, a researcher might opt to use LCA to better understand the data: Symptoms a, b, c, and d have been recorded in a variety of patients diagnosed with diseases X, Y, and Z. Disease X is associated with symptoms a, b, and c; disease Y is linked to symptoms b, c, and d; and disease Z is connected to symptoms a, c, and d. In this context, the LCA would attempt to detect the presence of latent classes (i.e., the disease entities), thus creating patterns of association in the symptoms. As in factor analysis, LCA can also be used to classify cases according to their maximum likelihood class membership probability. The key criterion for resolving the LCA is identifying latent classes in which the observed symptom associations are effectively rendered null. This is because within each class, the diseases responsible for the symptoms create a structure of dependencies. As a result, the symptoms become conditionally independent, meaning that, given the class a case belongs to, the symptoms are no longer related to one another. == Model == Within each latent class, the observed variables are statistically independent—an essential aspect of latent class modeling. Usually, the observed variables are statistically dependent. By introducing the latent variable, independence is restored in the sense that within classes, variables are independent (local independence). Therefore, the association between the observed variables is explained by the classes of the latent variable (McCutcheon, 1987). In one form, the LCM is written as p i 1 , i 2 , … , i N ≈ ∑ t T p t ∏ n N p i n , t n , {\displaystyle p_{i_{1},i_{2},\ldots ,i_{N}}\approx \sum _{t}^{T}p_{t}\,\prod _{n}^{N}p_{i_{n},t}^{n},} where T {\displaystyle T} is the number of latent classes and p t {\displaystyle p_{t}} are the so-called recruitment or unconditional probabilities that should sum to one. p i n , t n {\displaystyle p_{i_{n},t}^{n}} are the marginal or conditional probabilities. For a two-way latent class model, the form is p i j ≈ ∑ t T p t p i t p j t . {\displaystyle p_{ij}\approx \sum _{t}^{T}p_{t}\,p_{it}\,p_{jt}.} This two-way model is related to probabilistic latent semantic analysis and non-negative matrix factorization. The probability model used in LCA is closely related to the Naive Bayes classifier. The main difference is that in LCA, the class membership of an individual is a latent variable, whereas in Naive Bayes classifiers, the class membership is an observed label. == Related methods == There are a number of methods with distinct names and uses that share a common relationship. Cluster analysis is, like LCA, used to discover taxon-like groups of cases in data. Multivariate mixture estimation (MME) is applicable to continuous data and assumes that such data arise from a mixture of distributions, such as a set of heights arising from a mixture of men and women. If a multivariate mixture estimation is constrained so that measures must be uncorrelated within each distribution, it is termed latent profile analysis. Modified to handle discrete data, this constrained analysis is known as LCA. Discrete latent trait models further constrain the classes to form from segments of a single dimension, allocating members to classes based on that dimension. An example would be assigning cases to social classes based on ability or merit. In a practical instance, the variables could be multiple choice items of a political questionnaire. In this case, the data consists of an N-way contingency table with answers to the items for a number of respondents. In this example, the latent variable refers to political opinion, and the latent classes to political groups. Given group membership, the conditional probabilities specify the chance that certain answers are chosen. == Application == LCA may be used in many fields, such as: collaborative filtering, Behavior Genetics and Evaluation of diagnostic tests.

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  Gaussian process emulator

  In statistics, Gaussian process emulator is one name for a general type of statistical model that has been used in contexts where the problem is to make maximum use of the outputs of a complicated (often non-random) computer-based simulation model. Each run of the simulation model is computationally expensive and each run is based on many different controlling inputs. The variation of the outputs of the simulation model is expected to vary reasonably smoothly with the inputs, but in an unknown way. The overall analysis involves two models: the simulation model, or "simulator", and the statistical model, or "emulator", which notionally emulates the unknown outputs from the simulator. The Gaussian process emulator model treats the problem from the viewpoint of Bayesian statistics. In this approach, even though the output of the simulation model is fixed for any given set of inputs, the actual outputs are unknown unless the computer model is run and hence can be made the subject of a Bayesian analysis. The main element of the Gaussian process emulator model is that it models the outputs as a Gaussian process on a space that is defined by the model inputs. The model includes a description of the correlation or covariance of the outputs, which enables the model to encompass the idea that differences in the output will be small if there are only small differences in the inputs.

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  Soft independent modelling of class analogies

  Soft independent modelling by class analogy (SIMCA) is a statistical method for supervised classification of data. The method requires a training data set consisting of samples (or objects) with a set of attributes and their class membership. The term soft refers to the fact the classifier can identify samples as belonging to multiple classes and not necessarily producing a classification of samples into non-overlapping classes. == Method == In order to build the classification models, the samples belonging to each class need to be analysed using principal component analysis (PCA); only the significant components are retained. For a given class, the resulting model then describes either a line (for one Principal Component or PC), plane (for two PCs) or hyper-plane (for more than two PCs). For each modelled class, the mean orthogonal distance of training data samples from the line, plane, or hyper-plane (calculated as the residual standard deviation) is used to determine a critical distance for classification. This critical distance is based on the F-distribution and is usually calculated using 95% or 99% confidence intervals. New observations are projected into each PC model and the residual distances calculated. An observation is assigned to the model class when its residual distance from the model is below the statistical limit for the class. The observation may be found to belong to multiple classes and a measure of goodness of the model can be found from the number of cases where the observations are classified into multiple classes. The classification efficiency is usually indicated by Receiver operating characteristics. In the original SIMCA method, the ends of the hyper-plane of each class are closed off by setting statistical control limits along the retained principal components axes (i.e., score value between plus and minus 0.5 times score standard deviation). More recent adaptations of the SIMCA method close off the hyper-plane by construction of ellipsoids (e.g. Hotelling's T2 or Mahalanobis distance). With such modified SIMCA methods, classification of an object requires both that its orthogonal distance from the model and its projection within the model (i.e. score value within the region defined by the ellipsoid) are not significant. == Application == SIMCA as a method of classification has gained widespread use especially in applied statistical fields such as chemometrics and spectroscopic data analysis.

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  Mobile Passport Control

  Mobile Passport Control (MPC) is a mobile app that enables eligible travelers entering the United States to submit their passport information and customs declaration form to Customs and Border Protection via smartphone or tablet and go through the inspections process using an expedited lane. It is available to "U.S. citizens, U.S. lawful permanent residents, Canadian B1/B2 citizen visitors and returning Visa Waiver Program travelers with approved ESTA". The app is available on iOS and Android devices and is operational at 34 US airports, 14 international airports offering preclearance facilities, and 4 seaports. The use of Mobile Passport Control operations have increased threefold from 2016 to 2017. == History == Mobile Passport Control operations were launched in Atlanta at the Hartsfield-Jackson International Airport in 2016 and is now available at 34 U.S. airports, 14 international airports that offer preclearance and 4 U.S. cruise ports. The Mobile Passport app is authorized by CBP and sponsored by the Airports Council International-North America, Boeing, and the Port of Everglades. Airside Mobile, Inc. secured a Series A funding of $6 million in the fall of 2017. == How it works == During the customs process at the Federal Inspection Service (FIS) area of a U.S. airport, travelers arriving from international locations typically wait in long lines before presenting passports and paperwork and verbally answering questions made by CBP officials. Eligible travelers who have downloaded the Mobile Passport app can expedite this process by submitting information regarding their passport and trip details, and a newly-taken selfie, via their mobile device to CBP officials, then access an expedited line. Mobile Passport Control users will be required to show their physical passport(s) and briefly talk to a CBP officer. == Locations == === US airports === Atlanta (ATL) Baltimore (BWI) Boston (BOS) Charlotte (CLT) Chicago (ORD) Dallas/Ft Worth (DFW) Denver (DEN) Detroit (DTW) as of 7/2024 Ft. Lauderdale (FLL) Honolulu (HNL) Houston (HOU and IAH) Kansas City (MCI) Las Vegas (LAS) Los Angeles (LAX) Miami (MIA) Minneapolis (MSP) New York (JFK) Newark (EWR) Oakland (OAK) Orlando (MCO) Palm Beach (PBI) Philadelphia (PHL) Phoenix (PHX) Pittsburgh (PIT) Portland (PDX) Sacramento (SMF) San Diego (SAN) San Francisco (SFO) San Jose (SJC) San Juan (SJU) Seattle (SEA) Tampa (TPA) Washington Dulles (IAD) === International Preclearance locations === Abu Dhabi (AUH) Aruba (AUA) Bermuda (BDA) Calgary (YYC) Dublin (DUB) Edmonton (YEG) Halifax (YHZ) Montreal (YUL) Nassau (NAS) Ottawa (YOW) Shannon (SNN) Toronto (YYZ) Vancouver (YVR) Winnipeg (YWG) Sepinggan (BPN) === Seaports === Fort Lauderdale (PEV) Miami (MSE) San Juan (PUE) West Palm Beach (WPB)

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  Absorbing Markov chain

  In the mathematical theory of probability, an absorbing Markov chain is a Markov chain in which every state can reach an absorbing state. An absorbing state is a state that, once entered, cannot be left. Like general Markov chains, there can be continuous-time absorbing Markov chains with an infinite state space. However, this article concentrates on the discrete-time discrete-state-space case. == Formal definition == A Markov chain is an absorbing chain if there is at least one absorbing state and it is possible to go from any state to at least one absorbing state in a finite number of steps. In an absorbing Markov chain, a state that is not absorbing is called transient. === Canonical form === Let an absorbing Markov chain with transition matrix P have t transient states and r absorbing states. The rows of P represent sources, while columns represent destinations. By ordering the transient states before the absorbing states, it can be assumed that P has the form P = [ Q R 0 I r ] , {\displaystyle P={\begin{bmatrix}Q&R\\\mathbf {0} &I_{r}\end{bmatrix}},} where Q is a t-by-t matrix, R is a nonzero t-by-r matrix, 0 is an r-by-t zero matrix, and Ir is the r-by-r identity matrix. Thus, Q describes the probability of transitioning from some transient state to another while R describes the probability of transitioning from some transient state to some absorbing state. The probability of transitioning from i to j in exactly k steps is the (i,j)-entry of Pk, further computed below. When considering only transient states, the probability is found in the upper left of Pk, the (i,j)-entry of Qk. == Fundamental matrix == === Expected number of visits to a transient state === A basic property about an absorbing Markov chain is the expected number of visits to a transient state j starting from a transient state i (before being absorbed). This can be established to be given by the (i, j) entry of so-called fundamental matrix N, obtained by summing Qk for all k (from 0 to ∞). It can be proven that N := ∑ k = 0 ∞ Q k = ( I t − Q ) − 1 , {\displaystyle N:=\sum _{k=0}^{\infty }Q^{k}=(I_{t}-Q)^{-1},} where It is the t-by-t identity matrix. The computation of this formula is the matrix equivalent of the geometric series of scalars, ∑ k = 0 ∞ q k = 1 1 − q {\displaystyle {\textstyle \sum }_{k=0}^{\infty }q^{k}={\tfrac {1}{1-q}}} . With the matrix N in hand, also other properties of the Markov chain are easy to obtain. === Expected number of steps before being absorbed === The expected number of steps before being absorbed in any absorbing state, when starting in transient state i can be computed via a sum over transient states. The value is given by the ith entry of the vector t := N 1 , {\displaystyle \mathbf {t} :=N\mathbf {1} ,} where 1 is a length-t column vector whose entries are all 1. === Absorbing probabilities === By induction, P k = [ Q k ( I t − Q k ) N R 0 I r ] . {\displaystyle P^{k}={\begin{bmatrix}Q^{k}&(I_{t}-Q^{k})NR\\\mathbf {0} &I_{r}\end{bmatrix}}.} The probability of eventually being absorbed in the absorbing state j when starting from transient state i is given by the (i,j)-entry of the matrix B := N R {\displaystyle B:=NR} . The number of columns of this matrix equals the number of absorbing states r. An approximation of those probabilities can also be obtained directly from the (i,j)-entry of P k {\displaystyle P^{k}} for a large enough value of k, when i is the index of a transient, and j the index of an absorbing state. This is because ( lim k → ∞ P k ) i , t + j = B i , j {\displaystyle \left(\lim _{k\to \infty }P^{k}\right)_{i,t+j}=B_{i,j}} . === Transient visiting probabilities === The probability of visiting transient state j when starting at a transient state i is the (i,j)-entry of the matrix H := ( N − I t ) ( N dg ) − 1 , {\displaystyle H:=(N-I_{t})(N_{\operatorname {dg} })^{-1},} where Ndg is the diagonal matrix with the same diagonal as N. === Variance on number of transient visits === The variance on the number of visits to a transient state j with starting at a transient state i (before being absorbed) is the (i,j)-entry of the matrix N 2 := N ( 2 N dg − I t ) − N sq , {\displaystyle N_{2}:=N(2N_{\operatorname {dg} }-I_{t})-N_{\operatorname {sq} },} where Nsq is the Hadamard product of N with itself (i.e. each entry of N is squared). === Variance on number of steps === The variance on the number of steps before being absorbed when starting in transient state i is the ith entry of the vector ( 2 N − I t ) t − t sq , {\displaystyle (2N-I_{t})\mathbf {t} -\mathbf {t} _{\operatorname {sq} },} where tsq is the Hadamard product of t with itself (i.e., as with Nsq, each entry of t is squared). == Examples == === String generation === Consider the process of repeatedly flipping a fair coin until the sequence (heads, tails, heads) appears. This process is modeled by an absorbing Markov chain with transition matrix P = [ 1 / 2 1 / 2 0 0 0 1 / 2 1 / 2 0 1 / 2 0 0 1 / 2 0 0 0 1 ] . {\displaystyle P={\begin{bmatrix}1/2&1/2&0&0\\0&1/2&1/2&0\\1/2&0&0&1/2\\0&0&0&1\end{bmatrix}}.} The first state represents the empty string, the second state the string "H", the third state the string "HT", and the fourth state the string "HTH". Although in reality, the coin flips cease after the string "HTH" is generated, the perspective of the absorbing Markov chain is that the process has transitioned into the absorbing state representing the string "HTH" and, therefore, cannot leave. For this absorbing Markov chain, the fundamental matrix is N = ( I − Q ) − 1 = ( [ 1 0 0 0 1 0 0 0 1 ] − [ 1 / 2 1 / 2 0 0 1 / 2 1 / 2 1 / 2 0 0 ] ) − 1 = [ 1 / 2 − 1 / 2 0 0 1 / 2 − 1 / 2 − 1 / 2 0 1 ] − 1 = [ 4 4 2 2 4 2 2 2 2 ] . {\displaystyle {\begin{aligned}N&=(I-Q)^{-1}=\left({\begin{bmatrix}1&0&0\\0&1&0\\0&0&1\end{bmatrix}}-{\begin{bmatrix}1/2&1/2&0\\0&1/2&1/2\\1/2&0&0\end{bmatrix}}\right)^{-1}\\[4pt]&={\begin{bmatrix}1/2&-1/2&0\\0&1/2&-1/2\\-1/2&0&1\end{bmatrix}}^{-1}={\begin{bmatrix}4&4&2\\2&4&2\\2&2&2\end{bmatrix}}.\end{aligned}}} The expected number of steps starting from each of the transient states is t = N 1 = [ 4 4 2 2 4 2 2 2 2 ] [ 1 1 1 ] = [ 10 8 6 ] . {\displaystyle \mathbf {t} =N\mathbf {1} ={\begin{bmatrix}4&4&2\\2&4&2\\2&2&2\end{bmatrix}}{\begin{bmatrix}1\\1\\1\end{bmatrix}}={\begin{bmatrix}10\\8\\6\end{bmatrix}}.} Therefore, the expected number of coin flips before observing the sequence (heads, tails, heads) is 10, the entry for the state representing the empty string. === Games of chance === Games based entirely on chance can be modeled by an absorbing Markov chain. A classic example of this is the ancient Indian board game Snakes and Ladders. The graph on the left plots the probability mass in the lone absorbing state that represents the final square as the transition matrix is raised to larger and larger powers. To determine the expected number of turns to complete the game, compute the vector t as described above and examine tstart, which is approximately 39.2. === Infectious disease testing === Infectious disease testing, either of blood products or in medical clinics, is often taught as an example of an absorbing Markov chain. The public U.S. Centers for Disease Control and Prevention (CDC) model for HIV and for hepatitis B, for example, illustrates the property that absorbing Markov chains can lead to the detection of disease, versus the loss of detection through other means. In the standard CDC model, the Markov chain has five states, a state in which the individual is uninfected, then a state with infected but undetectable virus, a state with detectable virus, and absorbing states of having quit/been lost from the clinic, or of having been detected (the goal). The typical rates of transition between the Markov states are the probability p per unit time of being infected with the virus, w for the rate of window period removal (time until virus is detectable), q for quit/loss rate from the system, and d for detection, assuming a typical rate λ {\displaystyle \lambda } at which the health system administers tests of the blood product or patients in question. It follows that we can "walk along" the Markov model to identify the overall probability of detection for a person starting as undetected, by multiplying the probabilities of transition to each next state of the model as: p ( p + q ) w ( w + q ) d ( d + q ) {\displaystyle {\frac {p}{(p+q)}}{\frac {w}{(w+q)}}{\frac {d}{(d+q)}}} . The subsequent total absolute number of false negative tests—the primary CDC concern—would then be the rate of tests, multiplied by the probability of reaching the infected but undetectable state, times the duration of staying in the infected undetectable state: p ( p + q ) 1 ( w + q ) λ {\displaystyle {\frac {p}{(p+q)}}{\frac {1}{(w+q)}}\lambda } .

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  Taguchi loss function

  The Taguchi loss function is graphical depiction of loss developed by the Japanese business statistician Genichi Taguchi to describe a phenomenon affecting the value of products produced by a company. Praised by Dr. W. Edwards Deming (the business guru of the 1980s American quality movement), it made clear the concept that quality does not suddenly plummet when, for instance, a machinist exceeds a rigid blueprint tolerance. Instead 'loss' in value progressively increases as variation increases from the intended condition. This was considered a breakthrough in describing quality, and helped fuel the continuous improvement movement. The concept of Taguchi's quality loss function was in contrast with the American concept of quality, popularly known as goal post philosophy, the concept given by American quality guru Phil Crosby. Goal post philosophy emphasizes that if a product feature doesn't meet the designed specifications it is termed as a product of poor quality (rejected), irrespective of amount of deviation from the target value (mean value of tolerance zone). This concept has similarity with the concept of scoring a 'goal' in the game of football or hockey, because a goal is counted 'one' irrespective of the location of strike of the ball in the 'goal post', whether it is in the center or towards the corner. This means that if the product dimension goes out of the tolerance limit the quality of the product drops suddenly. Through his concept of the quality loss function, Taguchi explained that from the customer's point of view this drop of quality is not sudden. The customer experiences a loss of quality the moment product specification deviates from the 'target value'. This 'loss' is depicted by a quality loss function and it follows a parabolic curve mathematically given by L = k(y–m)2, where m is the theoretical 'target value' or 'mean value' and y is the actual size of the product, k is a constant and L is the loss. This means that if the difference between 'actual size' and 'target value' i.e. (y–m) is large, loss would be more, irrespective of tolerance specifications. In Taguchi's view tolerance specifications are given by engineers and not by customers; what the customer experiences is 'loss'. This equation is true for a single product; if 'loss' is to be calculated for multiple products the loss function is given by L = k[S2 + ( y ¯ {\displaystyle {\bar {y}}} – m)2], where S2 is the 'variance of product size' and y ¯ {\displaystyle {\bar {y}}} is the average product size. == Overview == The Taguchi loss function is important for a number of reasons—primarily, to help engineers better understand the importance of designing for variation.

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  Latent and observable variables

  In statistics, latent variables (from Latin: present participle of lateo 'lie hidden') are variables that can only be inferred indirectly through a mathematical model from other observable variables that can be directly observed or measured. Such latent variable models are used in many disciplines, including engineering, medicine, ecology, physics, machine learning/artificial intelligence, natural language processing, bioinformatics, chemometrics, demography, economics, management, political science, psychology and the social sciences. Latent variables may correspond to aspects of physical reality. These could in principle be measured, but may not be for practical reasons. Among the earliest expressions of this idea is Francis Bacon's polemic the Novum Organum, itself a challenge to the more traditional logic expressed in Aristotle's Organon: But the latent process of which we speak, is far from being obvious to men’s minds, beset as they now are. For we mean not the measures, symptoms, or degrees of any process which can be exhibited in the bodies themselves, but simply a continued process, which, for the most part, escapes the observation of the senses. In this situation, the term hidden variables is commonly used, reflecting the fact that the variables are meaningful, but not observable. Other latent variables correspond to abstract concepts, like categories, behavioral or mental states, or data structures. The terms hypothetical variables or hypothetical constructs may be used in these situations. The use of latent variables can serve to reduce the dimensionality of data. Many observable variables can be aggregated in a model to represent an underlying concept, making it easier to understand the data. In this sense, they serve a function similar to that of scientific theories. At the same time, latent variables link observable "sub-symbolic" data in the real world to symbolic data in the modeled world. == Examples == === Psychology === Latent variables, as created by factor analytic methods, generally represent "shared" variance, or the degree to which variables "move" together. Variables that have no correlation cannot result in a latent construct based on the common factor model. The "Big Five personality traits" have been inferred using factor analysis. extraversion spatial ability wisdom: “Two of the more predominant means of assessing wisdom include wisdom-related performance and latent variable measures.” Spearman's g, or the general intelligence factor in psychometrics === Economics === Examples of latent variables from the field of economics include quality of life, business confidence, morale, happiness and conservatism: these are all variables which cannot be measured directly. However, by linking these latent variables to other, observable variables, the values of the latent variables can be inferred from measurements of the observable variables. Quality of life is a latent variable which cannot be measured directly, so observable variables are used to infer quality of life. Observable variables to measure quality of life include wealth, employment, environment, physical and mental health, education, recreation and leisure time, and social belonging. === Medicine === Latent-variable methodology is used in many branches of medicine. A class of problems that naturally lend themselves to latent variables approaches are longitudinal studies where the time scale (e.g. age of participant or time since study baseline) is not synchronized with the trait being studied. For such studies, an unobserved time scale that is synchronized with the trait being studied can be modeled as a transformation of the observed time scale using latent variables. Examples of this include disease progression modeling and modeling of growth (see box). == Inferring latent variables == There exists a range of different model classes and methodology that make use of latent variables and allow inference in the presence of latent variables. Models include: linear mixed-effects models and nonlinear mixed-effects models Hidden Markov models Factor analysis Item response theory Analysis and inference methods include: Principal component analysis Instrumented principal component analysis Partial least squares regression Latent semantic analysis and probabilistic latent semantic analysis EM algorithms Metropolis–Hastings algorithm === Bayesian algorithms and methods === Bayesian statistics is often used for inferring latent variables. Latent Dirichlet allocation The Chinese restaurant process is often used to provide a prior distribution over assignments of objects to latent categories. The Indian buffet process is often used to provide a prior distribution over assignments of latent binary features to objects.

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  Semantic analysis (machine learning)

  In machine learning, semantic analysis of a text corpus is the task of building structures that approximate concepts from a large set of documents. It generally does not involve prior semantic understanding of the documents. Semantic analysis strategies include: Metalanguages based on first-order logic, which can analyze the speech of humans. Understanding the semantics of a text is symbol grounding: if language is grounded, it is equal to recognizing a machine-readable meaning. For the restricted domain of spatial analysis, a computer-based language understanding system was demonstrated. Latent semantic analysis (LSA), a class of techniques where documents are represented as vectors in a term space. A prominent example is probabilistic latent semantic analysis (PLSA). Latent Dirichlet allocation, which involves attributing document terms to topics. n-grams and hidden Markov models, which work by representing the term stream as a Markov chain, in which each term is derived from preceding terms. == Stochastic semantic analysis ==

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  Rprop

  Rprop, short for resilient backpropagation, is a learning heuristic for supervised learning in feedforward artificial neural networks. This is a first-order optimization algorithm. This algorithm was created by Martin Riedmiller and Heinrich Braun in 1992. Similarly to the Manhattan update rule, Rprop takes into account only the sign of the partial derivative over all patterns (not the magnitude), and acts independently on each "weight". For each weight, if there was a sign change of the partial derivative of the total error function compared to the last iteration, the update value for that weight is multiplied by a factor η−, where η− < 1. If the last iteration produced the same sign, the update value is multiplied by a factor of η+, where η+ > 1. The update values are calculated for each weight in the above manner, and finally each weight is changed by its own update value, in the opposite direction of that weight's partial derivative, so as to minimise the total error function. η+ is empirically set to 1.2 and η− to 0.5. Rprop can result in very large weight increments or decrements if the gradients are large, which is a problem when using mini-batches as opposed to full batches. RMSprop addresses this problem by keeping the moving average of the squared gradients for each weight and dividing the gradient by the square root of the mean square. RPROP is a batch update algorithm. Next to the cascade correlation algorithm and the Levenberg–Marquardt algorithm, Rprop is one of the fastest weight update mechanisms. == Variations == Martin Riedmiller developed three algorithms, all named RPROP. Igel and Hüsken assigned names to them and added a new variant: RPROP+ is defined at A Direct Adaptive Method for Faster Backpropagation Learning: The RPROP Algorithm. RPROP− is defined at Advanced Supervised Learning in Multi-layer Perceptrons – From Backpropagation to Adaptive Learning Algorithms. Backtracking is removed from RPROP+. iRPROP− is defined in Rprop – Description and Implementation Details and was reinvented by Igel and Hüsken. This variant is very popular and most simple. iRPROP+ is defined at Improving the Rprop Learning Algorithm and is very robust and typically faster than the other three variants.

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  Bioz

  Bioz is a search engine for life science experimentation. == History == Bioz was founded by Karin Lachmi and Daniel Levitt. Lachmi is a scientist who completed her postdoc in molecular and cellular biology at the Stanford University School of Medicine. During her lab work she found little available data regarding preferable lab tools, reagents and related products for experimentation. There are 50,000 vendors selling 300 million scientific products. She decided to start the company in order to provide researchers with adequate information for that purpose. Co-founder Daniel Levitt is an entrepreneur who sold his company WebAppoint to Microsoft in the year 2000. He also co-founded the company StemRad. At Bioz, Lachmi serves as the Chief Scientific Officer and Levitt serves as the chief executive officer. Bioz claims to have over a million researcher-users from 196 countries. Among the investors are Esther Dyson and the Stanford-StartX Fund. The company's advisory board includes Nobel Laureates in Chemistry Michael Levitt, Roger Kornberg, and Ada Yonath. == Technology == The company uses artificial intelligence, machine learning and natural language processing in order to extract experimentation data from scientific articles, such as the products that researchers used, the companies that supply the products, the protocol conditions that researchers selected, and the types of experiments and techniques. The algorithm ranks products based on how frequently they were used by researchers in their experiments, how recently a product was used, and the impact factor of the journal. The algorithm's output is a Bioz stars score for each product that was mentioned in an article. Bioz is a data-driven platform for product recommendations, which is contrary to platforms such as TripAdvisor and OpenTable that are based on user-generated reviews and ratings. The recommendations and scoring system that the company has developed are meant to assist researchers with the process of developing future medications and finding cures for diseases. They are guided towards products and techniques that were previously used by other researchers when planning and performing experiments. The company's revenue is based on selling SaaS subscriptions to researchers in biopharma companies. They also charge product suppliers for content syndication.

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