AI Assistant For Writing

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  Distributed file system for cloud

  A distributed file system for cloud is a file system that allows many clients to have access to data and supports operations (create, delete, modify, read, write) on that data. Each data file may be partitioned into several parts called chunks. Each chunk may be stored on different remote machines, facilitating the parallel execution of applications. Typically, data is stored in files in a hierarchical tree, where the nodes represent directories. There are several ways to share files in a distributed architecture: each solution must be suitable for a certain type of application, depending on how complex the application is. Meanwhile, the security of the system must be ensured. Confidentiality, availability and integrity are the main keys for a secure system. Users can share computing resources through the Internet thanks to cloud computing which is typically characterized by scalable and elastic resources – such as physical servers, applications and any services that are virtualized and allocated dynamically. Synchronization is required to make sure that all devices are up-to-date. Distributed file systems enable many big, medium, and small enterprises to store and access their remote data as they do local data, facilitating the use of variable resources. == Overview == === History === Today, there are many implementations of distributed file systems. The first file servers were developed by researchers in the 1970s. Sun Microsystem's Network File System became available in the 1980s. Before that, people who wanted to share files used the sneakernet method, physically transporting files on storage media from place to place. Once computer networks started to proliferate, it became obvious that the existing file systems had many limitations and were unsuitable for multi-user environments. Users initially used FTP to share files. FTP first ran on the PDP-10 at the end of 1973. Even with FTP, files needed to be copied from the source computer onto a server and then from the server onto the destination computer. Users were required to know the physical addresses of all computers involved with the file sharing. === Supporting techniques === Modern data centers must support large, heterogenous environments, consisting of large numbers of computers of varying capacities. Cloud computing coordinates the operation of all such systems, with techniques such as data center networking (DCN), the MapReduce framework, which supports data-intensive computing applications in parallel and distributed systems, and virtualization techniques that provide dynamic resource allocation, allowing multiple operating systems to coexist on the same physical server. === Applications === Cloud computing provides large-scale computing thanks to its ability to provide the needed CPU and storage resources to the user with complete transparency. This makes cloud computing particularly suited to support different types of applications that require large-scale distributed processing. This data-intensive computing needs a high performance file system that can share data between virtual machines (VM). Cloud computing dynamically allocates the needed resources, releasing them once a task is finished, requiring users to pay only for needed services, often via a service-level agreement. Cloud computing and cluster computing paradigms are becoming increasingly important to industrial data processing and scientific applications such as astronomy and physics, which frequently require the availability of large numbers of computers to carry out experiments. == Architectures == Most distributed file systems are built on the client-server architecture, but other, decentralized, solutions exist as well. === Client-server architecture === Network File System (NFS) uses a client-server architecture, which allows sharing of files between a number of machines on a network as if they were located locally, providing a standardized view. The NFS protocol allows heterogeneous clients' processes, probably running on different machines and under different operating systems, to access files on a distant server, ignoring the actual location of files. Relying on a single server results in the NFS protocol suffering from potentially low availability and poor scalability. Using multiple servers does not solve the availability problem since each server is working independently. The model of NFS is a remote file service. This model is also called the remote access model, which is in contrast with the upload/download model: Remote access model: Provides transparency, the client has access to a file. He sends requests to the remote file (while the file remains on the server). Upload/download model: The client can access the file only locally. It means that the client has to download the file, make modifications, and upload it again, to be used by others' clients. The file system used by NFS is almost the same as the one used by Unix systems. Files are hierarchically organized into a naming graph in which directories and files are represented by nodes. === Cluster-based architectures === A cluster-based architecture ameliorates some of the issues in client-server architectures, improving the execution of applications in parallel. The technique used here is file-striping: a file is split into multiple chunks, which are "striped" across several storage servers. The goal is to allow access to different parts of a file in parallel. If the application does not benefit from this technique, then it would be more convenient to store different files on different servers. However, when it comes to organizing a distributed file system for large data centers, such as Amazon and Google, that offer services to web clients allowing multiple operations (reading, updating, deleting,...) to a large number of files distributed among a large number of computers, then cluster-based solutions become more beneficial. Note that having a large number of computers may mean more hardware failures. Two of the most widely used distributed file systems (DFS) of this type are the Google File System (GFS) and the Hadoop Distributed File System (HDFS). The file systems of both are implemented by user level processes running on top of a standard operating system (Linux in the case of GFS). ==== Design principles ==== ===== Goals ===== Google File System (GFS) and Hadoop Distributed File System (HDFS) are specifically built for handling batch processing on very large data sets. For that, the following hypotheses must be taken into account: High availability: the cluster can contain thousands of file servers and some of them can be down at any time A server belongs to a rack, a room, a data center, a country, and a continent, in order to precisely identify its geographical location The size of a file can vary from many gigabytes to many terabytes. The file system should be able to support a massive number of files The need to support append operations and allow file contents to be visible even while a file is being written Communication is reliable among working machines: TCP/IP is used with a remote procedure call RPC communication abstraction. TCP allows the client to know almost immediately when there is a problem and a need to make a new connection. ===== Load balancing ===== Load balancing is essential for efficient operation in distributed environments. It means distributing work among different servers, fairly, in order to get more work done in the same amount of time and to serve clients faster. In a system containing N chunkservers in a cloud (N being 1000, 10000, or more), where a certain number of files are stored, each file is split into several parts or chunks of fixed size (for example, 64 megabytes), the load of each chunkserver being proportional to the number of chunks hosted by the server. In a load-balanced cloud, resources can be efficiently used while maximizing the performance of MapReduce-based applications. ===== Load rebalancing ===== In a cloud computing environment, failure is the norm, and chunkservers may be upgraded, replaced, and added to the system. Files can also be dynamically created, deleted, and appended. That leads to load imbalance in a distributed file system, meaning that the file chunks are not distributed equitably between the servers. Distributed file systems in clouds such as GFS and HDFS rely on central or master servers or nodes (Master for GFS and NameNode for HDFS) to manage the metadata and the load balancing. The master rebalances replicas periodically: data must be moved from one DataNode/chunkserver to another if free space on the first server falls below a certain threshold. However, this centralized approach can become a bottleneck for those master servers, if they become unable to manage a large number of file accesses, as it increases their already heavy loads. The load rebalance problem is NP-hard. In order to get a large number of chunkservers to work in collaboration, and to

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  Medoid

  Medoids are representative objects of a data set or a cluster within a data set whose sum of dissimilarities to all the objects in the cluster is minimal. Medoids are similar in concept to means or centroids, but medoids are always restricted to be members of the data set. Medoids are most commonly used on data when a mean or centroid cannot be defined, such as graphs. They are also used in contexts where the centroid is not representative of the dataset like in images, 3-D trajectories and gene expression (where while the data is sparse the medoid need not be). These are also of interest while wanting to find a representative using some distance other than squared euclidean distance (for instance in movie-ratings). For some data sets there may be more than one medoid, as with medians. A common application of the medoid is the k-medoids clustering algorithm, which is similar to the k-means algorithm but works when a mean or centroid is not definable. This algorithm basically works as follows. First, a set of medoids is chosen at random. Second, the distances to the other points are computed. Third, data are clustered according to the medoid they are most similar to. Fourth, the medoid set is optimized via an iterative process. Note that a medoid is not equivalent to a median, a geometric median, or centroid. A median is only defined on 1-dimensional data, and it only minimizes dissimilarity to other points for metrics induced by a norm (such as the Manhattan distance or Euclidean distance). A geometric median is defined in any dimension, but unlike a medoid, it is not necessarily a point from within the original dataset. == Definition == Let X := { x 1 , x 2 , … , x n } {\textstyle {\mathcal {X}}:=\{x_{1},x_{2},\dots ,x_{n}\}} be a set of n {\textstyle n} points in a space with a distance function d. Medoid is defined as x medoid = arg ⁡ min y ∈ X ∑ i = 1 n d ( y , x i ) . {\displaystyle x_{\text{medoid}}=\arg \min _{y\in {\mathcal {X}}}\sum _{i=1}^{n}d(y,x_{i}).} == Clustering with medoids == Medoids are a popular replacement for the cluster mean when the distance function is not (squared) Euclidean distance, or not even a metric (as the medoid does not require the triangle inequality). When partitioning the data set into clusters, the medoid of each cluster can be used as a representative of each cluster. Clustering algorithms based on the idea of medoids include: Partitioning Around Medoids (PAM), the standard k-medoids algorithm Hierarchical Clustering Around Medoids (HACAM), which uses medoids in hierarchical clustering == Algorithms to compute the medoid of a set == From the definition above, it is clear that the medoid of a set X {\displaystyle {\mathcal {X}}} can be computed after computing all pairwise distances between points in the ensemble. This would take O ( n 2 ) {\textstyle O(n^{2})} distance evaluations (with n = | X | {\displaystyle n=|{\mathcal {X}}|} ). In the worst case, one can not compute the medoid with fewer distance evaluations. However, there are many approaches that allow us to compute medoids either exactly or approximately in sub-quadratic time under different statistical models. If the points lie on the real line, computing the medoid reduces to computing the median which can be done in O ( n ) {\textstyle O(n)} by Quick-select algorithm of Hoare. However, in higher dimensional real spaces, no linear-time algorithm is known. RAND is an algorithm that estimates the average distance of each point to all the other points by sampling a random subset of other points. It takes a total of O ( n log ⁡ n ϵ 2 ) {\textstyle O\left({\frac {n\log n}{\epsilon ^{2}}}\right)} distance computations to approximate the medoid within a factor of ( 1 + ϵ Δ ) {\textstyle (1+\epsilon \Delta )} with high probability, where Δ {\textstyle \Delta } is the maximum distance between two points in the ensemble. Note that RAND is an approximation algorithm, and moreover Δ {\textstyle \Delta } may not be known apriori. RAND was leveraged by TOPRANK which uses the estimates obtained by RAND to focus on a small subset of candidate points, evaluates the average distance of these points exactly, and picks the minimum of those. TOPRANK needs O ( n 5 3 log 4 3 ⁡ n ) {\textstyle O(n^{\frac {5}{3}}\log ^{\frac {4}{3}}n)} distance computations to find the exact medoid with high probability under a distributional assumption on the average distances. trimed presents an algorithm to find the medoid with O ( n 3 2 2 Θ ( d ) ) {\textstyle O(n^{\frac {3}{2}}2^{\Theta (d)})} distance evaluations under a distributional assumption on the points. The algorithm uses the triangle inequality to cut down the search space. Meddit leverages a connection of the medoid computation with multi-armed bandits and uses an upper-Confidence-bound type of algorithm to get an algorithm which takes O ( n log ⁡ n ) {\textstyle O(n\log n)} distance evaluations under statistical assumptions on the points. Correlated Sequential Halving also leverages multi-armed bandit techniques, improving upon Meddit. By exploiting the correlation structure in the problem, the algorithm is able to provably yield drastic improvement (usually around 1-2 orders of magnitude) in both number of distance computations needed and wall clock time. == Implementations == An implementation of RAND, TOPRANK, and trimed can be found here. An implementation of Meddit can be found here and here. An implementation of Correlated Sequential Halving can be found here. == Medoids in text and natural language processing (NLP) == Medoids can be applied to various text and NLP tasks to improve the efficiency and accuracy of analyses. By clustering text data based on similarity, medoids can help identify representative examples within the dataset, leading to better understanding and interpretation of the data. === Text clustering === Text clustering is the process of grouping similar text or documents together based on their content. Medoid-based clustering algorithms can be employed to partition large amounts of text into clusters, with each cluster represented by a medoid document. This technique helps in organizing, summarizing, and retrieving information from large collections of documents, such as in search engines, social media analytics and recommendation systems. === Text summarization === Text summarization aims to produce a concise and coherent summary of a larger text by extracting the most important and relevant information. Medoid-based clustering can be used to identify the most representative sentences in a document or a group of documents, which can then be combined to create a summary. This approach is especially useful for extractive summarization tasks, where the goal is to generate a summary by selecting the most relevant sentences from the original text. === Sentiment analysis === Sentiment analysis involves determining the sentiment or emotion expressed in a piece of text, such as positive, negative, or neutral. Medoid-based clustering can be applied to group text data based on similar sentiment patterns. By analyzing the medoid of each cluster, researchers can gain insights into the predominant sentiment of the cluster, helping in tasks such as opinion mining, customer feedback analysis, and social media monitoring. === Topic modeling === Topic modeling is a technique used to discover abstract topics that occur in a collection of documents. Medoid-based clustering can be applied to group documents with similar themes or topics. By analyzing the medoids of these clusters, researchers can gain an understanding of the underlying topics in the text corpus, facilitating tasks such as document categorization, trend analysis, and content recommendation. === Techniques for measuring text similarity in medoid-based clustering === When applying medoid-based clustering to text data, it is essential to choose an appropriate similarity measure to compare documents effectively. Each technique has its advantages and limitations, and the choice of the similarity measure should be based on the specific requirements and characteristics of the text data being analyzed. The following are common techniques for measuring text similarity in medoid-based clustering: ==== Cosine similarity ==== Cosine similarity is a widely used measure to compare the similarity between two pieces of text. It calculates the cosine of the angle between two document vectors in a high-dimensional space. Cosine similarity ranges between -1 and 1, where a value closer to 1 indicates higher similarity, and a value closer to -1 indicates lower similarity. By visualizing two lines originating from the origin and extending to the respective points of interest, and then measuring the angle between these lines, one can determine the similarity between the associated points. Cosine similarity is less affected by document length, so it may be better at producing medoids that are representative of the content of a cluster instead of the lengt

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  Cartesian genetic programming

  Cartesian genetic programming is a form of genetic programming that uses a graph representation to encode computer programs. It grew from a method of evolving digital circuits developed by Julian F. Miller and Peter Thomson in 1997. The term ‘Cartesian genetic programming’ first appeared in 1999 and was proposed as a general form of genetic programming in 2000. It is called ‘Cartesian’ because it represents a program using a two-dimensional grid of nodes. Miller's keynote explains how CGP works. He edited a book entitled Cartesian Genetic Programming, published in 2011 by Springer. The open source project dCGP implements a differentiable version of CGP developed at the European Space Agency by Dario Izzo, Francesco Biscani and Alessio Mereta able to approach symbolic regression tasks, to find solution to differential equations, find prime integrals of dynamical systems, represent variable topology artificial neural networks and more.

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  Genetic operator

  A genetic operator is an operator used in evolutionary algorithms (EA) to guide the algorithm towards a solution to a given problem. There are three main types of operators (mutation, crossover and selection), which must work in conjunction with one another in order for the algorithm to be successful. Genetic operators are used to create and maintain genetic diversity (mutation operator), combine existing solutions (also known as chromosomes) into new solutions (crossover) and select between solutions (selection). The classic representatives of evolutionary algorithms include genetic algorithms, evolution strategies, genetic programming and evolutionary programming. In his book discussing the use of genetic programming for the optimization of complex problems, computer scientist John Koza has also identified an 'inversion' or 'permutation' operator; however, the effectiveness of this operator has never been conclusively demonstrated and this operator is rarely discussed in the field of genetic programming. For combinatorial problems, however, these and other operators tailored to permutations are frequently used by other EAs. Mutation (or mutation-like) operators are said to be unary operators, as they only operate on one chromosome at a time. In contrast, crossover operators are said to be binary operators, as they operate on two chromosomes at a time, combining two existing chromosomes into one new chromosome. == Operators == Genetic variation is a necessity for the process of evolution. Genetic operators used in evolutionary algorithms are analogous to those in the natural world: survival of the fittest, or selection; reproduction (crossover, also called recombination); and mutation. === Selection === Selection operators give preference to better candidate solutions (chromosomes), allowing them to pass on their 'genes' to the next generation (iteration) of the algorithm. The best solutions are determined using some form of objective function (also known as a 'fitness function' in evolutionary algorithms), before being passed to the crossover operator. Different methods for choosing the best solutions exist, for example, fitness proportionate selection and tournament selection. A further or the same selection operator is used to determine the individuals for being selected to form the next parental generation. The selection operator may also ensure that the best solution(s) from the current generation always become(s) a member of the next generation without being altered; this is known as elitism or elitist selection. === Crossover === Crossover is the process of taking more than one parent solutions (chromosomes) and producing a child solution from them. By recombining portions of good solutions, the evolutionary algorithm is more likely to create a better solution. As with selection, there are a number of different methods for combining the parent solutions, including the edge recombination operator (ERO) and the 'cut and splice crossover' and 'uniform crossover' methods. The crossover method is often chosen to closely match the chromosome's representation of the solution; this may become particularly important when variables are grouped together as building blocks, which might be disrupted by a non-respectful crossover operator. Similarly, crossover methods may be particularly suited to certain problems; the ERO is considered a good option for solving the travelling salesman problem. === Mutation === The mutation operator encourages genetic diversity amongst solutions and attempts to prevent the evolutionary algorithm converging to a local minimum by stopping the solutions becoming too close to one another. In mutating the current pool of solutions, a given solution may change between slightly and entirely from the previous solution. By mutating the solutions, an evolutionary algorithm can reach an improved solution solely through the mutation operator. Again, different methods of mutation may be used; these range from a simple bit mutation (flipping random bits in a binary string chromosome with some low probability) to more complex mutation methods in which genes in the solution are changed, for example by adding a random value from the Gaussian distribution to the current gene value. As with the crossover operator, the mutation method is usually chosen to match the representation of the solution within the chromosome. == Combining operators == While each operator acts to improve the solutions produced by the evolutionary algorithm working individually, the operators must work in conjunction with each other for the algorithm to be successful in finding a good solution. Using the selection operator on its own will tend to fill the solution population with copies of the best solution from the population. If the selection and crossover operators are used without the mutation operator, the algorithm will tend to converge to a local minimum, that is, a good but sub-optimal solution to the problem. Using the mutation operator on its own leads to a random walk through the search space. Only by using all three operators together can the evolutionary algorithm become a noise-tolerant global search algorithm, yielding good solutions to the problem at hand.

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  Open Data Center Alliance

  opendatacenteralliance.org appears to have been closed down. The Open Data Center Alliance is an independent organization created in Oct. 2010 with the assistance of Intel to coordinate the development of standards for cloud computing. Approximately 100 companies, which account for more than $50bn of IT spending, have joined the Alliance, including BMW, Royal Dutch Shell and Marriott Hotels. "The Alliance's Cloud 2015 vision is aimed at creating a federated cloud where common standards will be laid down for those in the hardware and software arena." == Usage Model Roadmap == The organization sees a growing need for solutions developed in an open, industry-standard and multivendor fashion, and has thus created a usage model roadmap featuring 19 prioritized usage models. The usage models provide detailed requirements for data center and cloud solutions, and will include detailed technical documentation discussing the requirements for technology deployments. To further its roadmap development, the steering committee established five initial technical workgroups in the areas of infrastructure, management, regulation & ecosystem, security and services. The organization delivered a 0.50 usage model roadmap to Open Data Center Alliance technical workgroups in Oct. 2010, and delivered a full 1.0 roadmap for public use in June 2011. == Membership == The steering committee consists of BMW, Capgemini, China Life, China Unicom Group, Deutsche Bank, JPMorgan Chase, Lockheed Martin, Marriott International, Inc., National Australia Bank, Royal Dutch Shell, Terremark and UBS. Other members include AT&T, CERN, eBay, Logica, Motorola Mobility Inc. and Nokia. "The demands on the IT organisations are coming at such an alarming rate that there are many, many different solutions being developed today that maybe don't work with each other. We need one voice, one road map, so that companies are able to say to manufacturers here is a clear vision of what they should be developing their product to do." says Marvin Wheeler, of Terremark, chairman of the Alliance. "While it's unclear how successful this alliance will be, it is at least shedding the spotlight on cloud interoperability, a big emerging issue," said Larry Dignan of ZDNet.

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  Relationship square

  In statistics, the relationship square is a graphical representation for use in the factorial analysis of a table individuals x variables. This representation completes classical representations provided by principal component analysis (PCA) or multiple correspondence analysis (MCA), namely those of individuals, of quantitative variables (correlation circle) and of the categories of qualitative variables (at the centroid of the individuals who possess them). It is especially important in factor analysis of mixed data (FAMD) and in multiple factor analysis (MFA). == Definition of relationship square in the MCA frame == The first interest of the relationship square is to represent the variables themselves, not their categories, which is all the more valuable as there are many variables. For this, we calculate for each qualitative variable j {\displaystyle j} and each factor F s {\displaystyle F_{s}} ( F s {\displaystyle F_{s}} , rank s {\displaystyle s} factor, is the vector of coordinates of the individuals along the axis of rank s {\displaystyle s} ; in PCA, F s {\displaystyle F_{s}} is called principal component of rank s {\displaystyle s} ), the square of the correlation ratio between the F s {\displaystyle F_{s}} and the variable j {\displaystyle j} , usually denoted : η 2 ( j , F s ) {\displaystyle \eta ^{2}(j,F_{s})} Thus, to each factorial plane, we can associate a representation of qualitative variables themselves. Their coordinates being between 0 and 1, the variables appear in the square having as vertices the points (0,0), ( 0,1), (1,0) and (1,1). == Example in MCA == Six individuals ( i 1 , … , i 6 ) {\displaystyle i_{1},\ldots ,i_{6})} are described by three variables ( q 1 , q 2 , q 3 ) {\displaystyle (q_{1},q_{2},q_{3})} having respectively 3, 2 and 3 categories. Example : the individual i 1 {\displaystyle i_{1}} possesses the category a {\displaystyle a} of q 1 {\displaystyle q_{1}} , d {\displaystyle d} of q 2 {\displaystyle q_{2}} and f {\displaystyle f} of q 3 {\displaystyle q_{3}} . Applied to these data, the MCA function included in the R Package FactoMineR provides to the classical graph in Figure 1. The relationship square (Figure 2) makes easier the reading of the classic factorial plane. It indicates that: The first factor is related to the three variables but especially q 3 {\displaystyle q_{3}} (which have a very high coordinate along the first axis) and then q 2 {\displaystyle q_{2}} . The second factor is related only to q 1 {\displaystyle q_{1}} and q 3 {\displaystyle q_{3}} (and not to q 2 {\displaystyle q_{2}} which has a coordinate along axis 2 equal to 0) and that in a strong and equal manner. All this is visible on the classic graphic but not so clearly. The role of the relationship square is first to assist in reading a conventional graphic. This is precious when the variables are numerous and possess numerous coordinates. == Extensions == This representation may be supplemented with those of quantitative variables, the coordinates of the latter being the square of correlation coefficients (and not of correlation ratios). Thus, the second advantage of the relationship square lies in the ability to represent simultaneously quantitative and qualitative variables. The relationship square can be constructed from any factorial analysis of a table individuals x variables. In particular, it is (or should be) used systematically: in multiple correspondences analysis (MCA); in principal components analysis (PCA) when there are many supplementary variables; in factor analysis of mixed data (FAMD). An extension of this graphic to groups of variables (how to represent a group of variables by a single point ?) is used in Multiple Factor Analysis (MFA) == History == The idea of representing the qualitative variables themselves by a point (and not the categories) is due to Brigitte Escofier. The graphic as it is used now has been introduced by Brigitte Escofier and Jérôme Pagès in the framework of multiple factor analysis == Conclusion == In MCA, the relationship square provides a synthetic view of the connections between mixed variables, all the more valuable as there are many variables having many categories. This representation iscan be useful in any factorial analysis when there are numerous mixed variables, active and/or supplementary.

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  NOMINATE (scaling method)

  NOMINATE (an acronym for nominal three-step estimation) is a multidimensional scaling application developed by US political scientists Keith T. Poole and Howard Rosenthal in the early 1980s to analyze preferential and choice data, such as legislative roll-call voting behavior. In its most well-known application, members of the US Congress are placed on a two-dimensional map, with politicians who are ideologically similar (i.e. who often vote the same) being close together. One of these two dimensions corresponds to the familiar left–right political spectrum (liberal–conservative in the United States). As computing capabilities grew, Poole and Rosenthal developed multiple iterations of their NOMINATE procedure: the original D-NOMINATE method, W-NOMINATE, and most recently DW-NOMINATE (for dynamic, weighted NOMINATE). In 2009, Poole and Rosenthal were the first recipients of the Society for Political Methodology's Best Statistical Software Award for their development of NOMINATE. In 2016, the society awarded Poole its Career Achievement Award, stating that "the modern study of the U.S. Congress would be simply unthinkable without NOMINATE legislative roll call voting scores." == Procedure == The main procedure is an application of multidimensional scaling techniques to political choice data. Though there are important technical differences between these types of NOMINATE scaling procedures, all operate under the same fundamental assumptions. First, that alternative choices can be projected on a basic, low-dimensional (often two-dimensional) Euclidean space. Second, within that space, individuals have utility functions which are bell-shaped (normally distributed), and maximized at their ideal point. Because individuals also have symmetric, single-peaked utility functions which center on their ideal point, ideal points represent individuals' most preferred outcomes. That is, individuals most desire outcomes closest their ideal point, and will choose/vote probabilistically for the closest outcome. Ideal points can be recovered from observing choices, with individuals exhibiting similar preferences placed more closely than those behaving dissimilarly. It is helpful to compare this procedure to producing maps based on driving distances between cities. For example, Los Angeles is about 1,800 miles from St. Louis; St. Louis is about 1,200 miles from Miami; and Miami is about 2,700 miles from Los Angeles. From this (dis)similarities data, any map of these three cities should place Miami far from Los Angeles, with St. Louis somewhere in between (though a bit closer to Miami than Los Angeles). Just as cities like Los Angeles and San Francisco would be clustered on a map, NOMINATE places ideologically similar legislators (e.g., liberal Senators Barbara Boxer (D-Calif.) and Al Franken (D-Minn.)) closer to each other, and farther from dissimilar legislators (e.g., conservative Senator Tom Coburn (R-Okla.)) based on the degree of agreement between their roll call voting records. At the heart of the NOMINATE procedures (and other multidimensional scaling methods, such as Poole's Optimal Classification method) are algorithms they utilize to arrange individuals and choices in low dimensional (usually two-dimensional) space. Thus, NOMINATE scores provide "maps" of legislatures. Using NOMINATE procedures to study congressional roll call voting behavior from the First Congress to the present-day, Poole and Rosenthal published Congress: A Political-Economic History of Roll Call Voting in 1997 and the revised edition Ideology and Congress in 2007. In 2009, Poole and Rosenthal were named the first recipients of the Society for Political Methodology's Best Statistical Software Award for their development of NOMINATE, a recognition conferred to "individual(s) for developing statistical software that makes a significant research contribution". In 2016, Keith T. Poole was awarded the Society for Political Methodology's Career Achievement Award. The citation for this award reads, in part, "One can say perfectly correctly, and without any hyperbole: the modern study of the U.S. Congress would be simply unthinkable without NOMINATE legislative roll call voting scores. NOMINATE has produced data that entire bodies of our discipline—and many in the press—have relied on to understand the U.S. Congress." == Dimensions == Poole and Rosenthal demonstrate that—despite the many complexities of congressional representation and politics—roll call voting in both the House and the Senate can be organized and explained by no more than two dimensions throughout the sweep of American history. The first dimension (horizontal or x-axis) is the familiar left-right (or liberal-conservative) spectrum on economic matters. The second dimension (vertical or y-axis) picks up attitudes on cross-cutting, salient issues of the day (which include or have included slavery, bimetallism, civil rights, regional, and social/lifestyle issues). Rosenthal and Poole have initially argued that the first dimension refers to socio-economic matters and the second dimension to race-relations. However, the often confusing and residual nature of the second dimension has led to the second dimension being largely ignored by other researchers. For the most part, congressional voting is uni-dimensional, with most of the variation in voting patterns explained by placement along the liberal-conservative first dimension. While the first dimension of the DW-NOMINATE score is able to predict results at 83% accuracy, the addition of the second dimension only increases accuracy to 85%. Furthermore, the second dimension only provided a significant increase in accuracy for Congresses 1-99. As late as the 1990s, the second dimension was able to measure partisan splits in abortion and gun rights issues. However, a 2017 analysis found that since 1987, the votes of the US Congress had best fit a one-dimensional model, suggesting increasing party polarization after 1987. == Interpretation of nominate scores == For illustrative purposes, consider the following plots which use W-NOMINATE scores to scale members of Congress and uses the probabilistic voting model (in which legislators farther from the "cutting line" between "yea" and "nay" outcomes become more likely to vote in the predicted manner) to illustrate some major Congressional votes in the 1990s. Some of these votes, like the House's vote on President Clinton's welfare reform package (the Personal Responsibility and Work Opportunity Act of 1996) are best modeled through the use of the first (economic liberal-conservative) dimension. On the welfare reform vote, nearly all Republicans joined the moderate-conservative bloc of House Democrats in voting for the bill, while opposition was virtually confined to the most liberal Democrats in the House. The errors (those representatives on the "wrong" side of the cutting line which separates predicted "yeas" and predicted "nays") are generally close to the cutting line, which is what we would expect. A legislator directly on the cutting line is indifferent between voting "yea" and "nay" on the measure. All members are shown on the left panel of the plot, while only errors are shown on the right panel: Economic ideology also dominates the Senate vote on the Balanced Budget Amendment of 1995: On other votes, however, a second dimension (which has recently come to represent attitudes on cultural and lifestyle issues) is important. For example, roll call votes on gun control routinely split party coalitions, with socially conservative "blue dog" Democrats joining most Republicans in opposing additional regulation and socially liberal Republicans joining most Democrats in supporting gun control. The addition of the second dimension accounts for these inter-party differences, and the cutting line is more horizontal than vertical (meaning the cleavage is found on the second dimension rather than the first dimension on these votes) This pattern was evident in the 1991 House vote to require waiting periods on handguns: == Political ideology == DW-NOMINATE scores have been used widely to describe the political ideology of political actors, political parties and political institutions. For instance, a score in the first dimension that is close to either pole means that such score is located at one of the extremes in the liberal-conservative scale. So, a score closer to 1 is described as conservative whereas a score closer to −1 can be described as liberal. Finally, a score at zero or close to zero is described as moderate. == Political polarization == Poole and Rosenthal (beginning with their 1984 article "The Polarization of American Politics") have also used NOMINATE data to show that, since the 1970s, party delegations in Congress have become ideologically homogeneous and distant from one another (a phenomenon known as "polarization"). Using DW-NOMINATE scores (which permit direct comparisons between members of different Congress

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  Targeted maximum likelihood estimation

  Targeted Maximum Likelihood Estimation (TMLE) (also more accurately referred to as Targeted Minimum Loss-Based Estimation) is a general statistical estimation framework for causal inference and semiparametric models. TMLE combines ideas from maximum likelihood estimation, semiparametric efficiency theory, and machine learning. It was introduced by Mark J. van der Laan and colleagues in the mid-2000s as a method that yields asymptotically efficient plug-in estimators while allowing the use of flexible, data-adaptive algorithms such as ensemble machine learning for nuisance parameter estimation. TMLE is used in epidemiology, biostatistics, and the social sciences to estimate causal effects in observational and experimental studies. Applications of TMLE include Longitudinal TMLE (LTMLE) for time-varying treatments and confounders. Variations in how the targeting step in TMLE is carried out have resulted in various versions of TMLE such as Collaborative TMLE (CTMLE) and Adaptive TMLE for improved finite-sample performance and automated variable selection. == History == The TMLE framework was first described by van der Laan and Rubin (2006) as a general approach for the construction of efficient plug-in estimators of smooth features of the data density. It was demonstrated in the context of causal inference and missing data problems. It was developed to address limitations of traditional doubly robust methods, such as Augmented Inverse Probability Weighting (AIPW), by respecting the plug-in principle in the sense that it respects that the target parameter is a function of the data density that is an element of the statistical model. TMLE estimates the data density or relevant parts of it with machine learning and targets these machine learning fits before it is plugged in the target parameter mapping. In this manner, a TMLE always respects global knowledge and satisfies known bounds such as that the target parameter is a probability . Since its introduction, TMLE has been developed in a series of theoretical and applied papers, culminating in book-length treatments of the method and its applications to survival analysis, adaptive designs, and longitudinal data. == Methodology == At its core, TMLE is a two-step estimation procedure: Initial estimation: Machine learning methods (such as the Super Learner ensemble) are used to obtain flexible estimates of nuisance parameters, such as outcome regressions and propensity scores. Targeting step: The initial estimate is updated by solving a score equation (the efficient influence function) so that the final estimator is consistent, asymptotically normal, and efficient under mild regularity conditions. The targeted machine learning fit is then mapped into the corresponding estimator of the target parameter by simply plugging it in the target parameter mapping. This approach balances the bias–variance trade-off by combining data-adaptive estimation with semiparametric efficiency theory. TMLE is doubly robust, meaning it remains consistent if either the outcome model or the treatment model is consistently estimated. === Formula === Here we explain the TMLE of the average treatment effect of a binary treatment on an outcome adjusting for baseline covariates. Consider i.i.d. observations O i = ( W i , A i , Y i ) {\displaystyle O_{i}=(W_{i},A_{i},Y_{i})} from a distribution P 0 {\displaystyle P_{0}} , where W {\displaystyle W} are baseline covariates, A {\displaystyle A} is a binary treatment, and Y {\displaystyle Y} is an outcome. Let Q ¯ ( a , w ) = E [ Y ∣ A = a , W = w ] {\displaystyle {\bar {Q}}(a,w)=\mathbb {E} [Y\mid A=a,W=w]} represent the outcome model and g ( a ∣ w ) = P ( A = a ∣ W = w ) {\displaystyle g(a\mid w)=P(A=a\mid W=w)} represent the propensity score. The average treatment effect (ATE) is given by ψ 0 = E { Q ¯ ( 1 , W ) − Q ¯ ( 0 , W ) } . {\displaystyle \psi _{0}=\mathbb {E} \{{\bar {Q}}(1,W)-{\bar {Q}}(0,W)\}.} A basic TMLE for the ATE proceeds as follows: Step 1: Estimate initial models. Obtain estimates Q ¯ ^ ( a , w ) {\displaystyle {\hat {\bar {Q}}}(a,w)} and g ^ ( a ∣ w ) {\displaystyle {\hat {g}}(a\mid w)} , often using flexible methods such as Super Learner. Step 2: Compute the clever covariate. Define: H ( A , W ) = A g ^ ( 1 ∣ W ) − 1 − A g ^ ( 0 ∣ W ) . {\displaystyle H(A,W)={\frac {A}{{\hat {g}}(1\mid W)}}-{\frac {1-A}{{\hat {g}}(0\mid W)}}.} Step 3: Estimate the fluctuation parameter. Fit a logistic regression of Y {\displaystyle Y} on H ( A , W ) {\displaystyle H(A,W)} with logit ⁡ ( Q ¯ ^ ( A , W ) ) {\displaystyle \operatorname {logit} ({\hat {\bar {Q}}}(A,W))} as offset. This yields ε ^ {\displaystyle {\hat {\varepsilon }}} , the MLE that solves the score equation: 1 n ∑ i = 1 n H ( A i , W i ) { Y i − Q ¯ ^ ε ( A i , W i ) } = 0. {\displaystyle {\frac {1}{n}}\sum _{i=1}^{n}H(A_{i},W_{i}){\big \{}Y_{i}-{\hat {\bar {Q}}}^{\varepsilon }(A_{i},W_{i}){\big \}}=0.} Step 4: Update the initial estimate. Apply the "blip" to obtain the targeted estimate: Q ¯ ^ ∗ ( A , W ) = expit ⁡ ( logit ⁡ ( Q ¯ ^ ( A , W ) ) + ε ^ H ( A , W ) ) . {\displaystyle {\hat {\bar {Q}}}^{}(A,W)=\operatorname {expit} {\Big (}\operatorname {logit} {\big (}{\hat {\bar {Q}}}(A,W){\big )}+{\hat {\varepsilon }}\,H(A,W){\Big )}.} Step 5: Compute the TMLE. The ATE estimate is: ψ ^ TMLE = 1 n ∑ i = 1 n [ Q ¯ ^ ∗ ( 1 , W i ) − Q ¯ ^ ∗ ( 0 , W i ) ] . {\displaystyle {\hat {\psi }}_{\text{TMLE}}={\frac {1}{n}}\sum _{i=1}^{n}{\big [}{\hat {\bar {Q}}}^{}(1,W_{i})-{\hat {\bar {Q}}}^{}(0,W_{i}){\big ]}.} Inference. The efficient influence function (EIF) for the ATE is: D ∗ ( O ) = H ( A , W ) { Y − Q ¯ ∗ ( A , W ) } + Q ¯ ∗ ( 1 , W ) − Q ¯ ∗ ( 0 , W ) − ψ . {\displaystyle D^{}(O)=H(A,W)\{Y-{\bar {Q}}^{}(A,W)\}+{\bar {Q}}^{}(1,W)-{\bar {Q}}^{}(0,W)-\psi .} The variance is estimated by σ ^ 2 = n − 1 ∑ i = 1 n ( D ∗ ( O i ) ) 2 {\displaystyle {\hat {\sigma }}^{2}=n^{-1}\sum _{i=1}^{n}{\big (}D^{}(O_{i}){\big )}^{2}} , yielding Wald-type confidence intervals ψ ^ TMLE ± z 1 − α / 2 σ ^ / n {\displaystyle {\hat {\psi }}_{\text{TMLE}}\pm z_{1-\alpha /2}\,{\hat {\sigma }}/{\sqrt {n}}} . Remark. For continuous outcomes, a linear fluctuation Q ¯ ^ ∗ = Q ¯ ^ + ε ^ H {\displaystyle {\hat {\bar {Q}}}^{}={\hat {\bar {Q}}}+{\hat {\varepsilon }}\,H} may be used instead. For bounded continuous outcomes, the logistic fluctuation (after rescaling Y {\displaystyle Y} to [ 0 , 1 ] {\displaystyle [0,1]} ) is often preferred for improved finite-sample performance. == Applications == TMLE has been applied in: Epidemiology: Estimating causal effects of exposures and interventions in observational cohort studies. Clinical trials and real-world evidence: The Targeted Learning roadmap provides a structured framework for generating and validating real-world evidence (RWE), bridging randomized trials and observational data using TMLE and related estimation techniques. This approach enables transparency, sensitivity analysis, and stronger causal inference for regulatory and clinical trial contexts. High-dimensional settings: Integration with ensemble methods for causal effect estimation. TMLE has been successfully applied in pharmacoepidemiology where a large number of covariates are automatically selected to adjust for confounding. In a study of post–myocardial infarction statin use and 1-year mortality, TMLE demonstrated robust performance relative to inverse probability weighting in scenarios with hundreds of potential confounders. == Derivatives and extensions == Longitudinal TMLE (LTMLE): A methodological extension of TMLE for longitudinal data with time-varying treatments, confounders, and censoring. It allows the estimation of dynamic treatment regimes and intervention-specific causal effects over time. This framework was originally introduced by van der Laan & Gruber (2012). Collaborative TMLE (CTMLE): Enhances finite-sample performance and variable selection by collaboratively fitting the treatment mechanism in conjunction with the target parameter. == Software == Several R packages implement TMLE and related methods: tmle: Functions for binary, categorical, and continuous outcomes. ltmle: Implementation for longitudinal data with time-varying treatments and outcomes. ctmle: Algorithms for collaborative TMLE and adaptive variable selection. SuperLearner: A theoretically grounded, cross-validated ensemble learning method that combines predictions from multiple algorithms to minimize predictive risk. Widely used in TMLE for estimating nuisance parameters. The original implementation is available as the R package SuperLearner. Recent machine learning platforms like H2O AutoML implement similar ensemble strategies, combining diverse learners in parallel and leveraging stacking and blending techniques, effectively functioning as a large-scale Super Learner.

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  Automated medical scribe

  Automated medical scribes (also called artificial intelligence scribes, AI scribes, digital scribes, virtual scribes, ambient AI scribes, AI documentation assistants, and digital/virtual/smart clinical assistants) are tools for transcribing medical speech, such as patient consultations and dictated medical notes. Many also produce summaries of consultations. Automated medical scribes based on large language models (LLMs, commonly called "AI", short for "artificial intelligence") increased drastically in popularity in 2024. There are privacy and antitrust concerns. Accuracy concerns also exist, and intensify in situations in which tools try to go beyond transcribing and summarizing, and are asked to format information by its meaning, since LLMs do not deal well with meaning (see weak artificial intelligence). Medics using these scribes are generally expected to understand the ethical and legal considerations, and supervise the outputs. The privacy protections of automated medical scribes vary widely. While it is possible to do all the transcription and summarizing locally, with no connection to the internet, most closed-source providers require that data be sent to their own servers over the internet, processed there, and the results sent back (as with digital voice assistants). Some retailers say their tools use zero-knowledge encryption (meaning that the service provider can't access the data). Others explicitly say that they use patient data to train their AIs, or rent or resell it to third parties; the nature of privacy protections used in such situations is unclear, and they are likely not to be fully effective. Most providers have not published any safety or utility data in academic journals, and are not responsive to requests from medical researchers studying their products. == Privacy == Some providers unclear about what happens to user data. Some may sell data to third parties. Some explicitly send user data to for-profit tech companies for secondary purposes, which may not be specified. Some require users to sign consents to such reuse of their data. Some ingest user data to train the software, promising to anonymize it; however, deanonymization may be possible (that is, it may become obvious who the patient is). It is intrinsically impossible to prevent an LLM from correlating its inputs; they work by finding similar patterns across very large data sets. Some information on the patient will be known from other sources (for instance, information that they were injured in an incident on a certain day might be available from the news media; information that they attended specific appointment locations at specific times is probably available to their cellphone provider/apps/data brokers; information about when they had a baby is probably implied by their online shopping records; and they might mention lifestyle changes to their doctor and on a forum or blog). The software may correlate such information with the "anonymized" clinical consultation record, and, asked about the named patient, provide information which they only told their doctor privately. Because a patient's record is all about the same patient, it is all unavoidably linked; in very many cases, medical histories are intrinsically identifiable. Depending on how common a condition and what other data is available, K-anonymity may be useless. Differential privacy could theoretically preserve privacy. Data broker companies like Google, Amazon, Apple and Microsoft have produced or bought up medical scribes, some of which use user data for secondary purposes, which has led to antitrust concerns. Transfer of patient records for AI training has, in the past, prompted legal action. Open-source programs typically do all the transcription locally, on the doctor's own computer. Open-source software is widely used in healthcare, with some national public healthcare bodies holding hack days. === Data resale and commercialization === Several AI medical scribe providers include terms in their service agreements that allow the reuse, sale, or commercialization of de-identified or user-submitted data. Although such data are generally described as anonymized or aggregated, these practices have raised ethical concerns among clinicians and privacy advocates regarding secondary uses of medical information beyond clinical documentation. Freed, an AI transcription and scribe platform, states in its Terms of Use that it may "collect, use, publish, disseminate, sell, transfer, and otherwise exploit" de-identified and aggregated data derived from user inputs. OpenEvidence similarly states that it may "collect, use, transfer, sell, and disclose non-personal information and customer usage data for any purpose including commercial uses." Doximity, which offers an AI-enabled medical scribe as part of its physician platform, grants itself a "nonexclusive, irrevocable, worldwide, perpetual, unlimited, assignable, sublicensable, royalty-free" license to "copy, prepare derivative works from, improve, distribute, publish, ... analyze, index, tag, [and] commercialize" content submitted by users, subject to its privacy policy. Because these terms allow broad secondary use—including sale, licensing, model-training, derivative works, and commercial exploitation of de-identified or user-submitted data—some commentators have recommended that clinicians review data-handling provisions carefully when adopting AI-scribe tools, particularly in clinical environments where patient privacy and regulatory compliance are critical. === Encryption === Multifactor authentication for access to the data is expected practice. Typically, Diffie–Hellman key exchange is used for encryption; this is the standard method commonly used for things like online banking. This encryption is expensive but not impossible to break; it is not generally considered safe against eavesdroppers with the resources of a nation-state. If content is encrypted between the client and the service provider's remote server (transport cryptography), then the server has an unencrypted copy. This is necessary if the data is used by the service provider (for instance, to train the software). Zero-knowledge encryption implies that the only unencrypted copy is at the client, and the server cannot decrypt the data any more easily than a monster-in-the-middle attacker. == Platforms == Scribes may operate on desktops, laptop, or mobile computers, under a variety of operating systems. These vary in their risks; for instance, mobiles can be lost. The underlying mobile or desktop operating systems are also part of the trusted computing base, and if they are not secure, the software relying on them cannot be secure either. Some AI medical scribe platforms are designed to operate as cloud-based applications that generate structured clinical documentation from clinician–patient conversations. These systems may offer features such as real-time transcription, document generation, and integration with electronic health record (EHR) systems. == Confabulation, omissions, and other errors == Like other LLMs, medical-scribe LLMs are prone to hallucinations, where they make up content based on statistically associations between their training data and the transcription audio. LLMs do not distinguish between trying to transcribe the audio and guessing what words will come next, but perform both processes mixed together. They are especially likely to take short silences or non-speech noises and invent some sort of speech to transcribe them as. LLM medical scribes have been known to confabulate racist and otherwise prejudiced content; this is partly because the training datasets of many LLMs contain pseudoscientific texts about medical racism. They may misgender patients. A survey found that most doctors preferred, in principle, that scribes be trained on data reviewed by medical subject experts. Relevant, accurate training data increases the probability of an accurate transcription, but does not guarantee accuracy. Software trained on thousands of real clinical conversations generated transcripts with lower word error rates. Software trained on manually-transcribed training data did better than software trained with automatically transcribed training data such as YouTube captions. Autoscribes omit parts of the conversation classes as irrelevant. The may wrongly classify pertinent information as irrelevant and omit it. They may also confuse historic and current symptoms, or otherwise misclassify information. They may also simply wrongly transcribe the speech, writing something incorrect instead. If clinicians do not carefully check the recording, such mistakes could make their way into their medical records and cause patient harms. == Patient consent == Professional organizations generally require that scribes be used only with patient consent; some bodies may require written consent. Medics must also abide by local surveillance laws, which may criminalize recording pri

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  Correspondence analysis

  Correspondence analysis (CA) is a multivariate statistical technique proposed by Herman Otto Hartley (Hirschfeld) and later developed by Jean-Paul Benzécri. It is conceptually similar to principal component analysis, but applies to categorical rather than continuous data. In a manner similar to principal component analysis, it provides a means of displaying or summarising a set of data in two-dimensional graphical form. Its aim is to display in a biplot any structure hidden in the multivariate setting of the data table. As such it is a technique from the field of multivariate ordination. Since the variant of CA described here can be applied either with a focus on the rows or on the columns it should in fact be called simple (symmetric) correspondence analysis. It is traditionally applied to the contingency table of a pair of nominal variables where each cell contains either a count or a zero value. If more than two categorical variables are to be summarized, a variant called multiple correspondence analysis should be chosen instead. CA may also be applied to binary data given the presence/absence coding represents simplified count data i.e. a 1 describes a positive count and 0 stands for a count of zero. Depending on the scores used CA preserves the chi-square distance between either the rows or the columns of the table. Because CA is a descriptive technique, it can be applied to tables regardless of a significant chi-squared test. Although the χ 2 {\displaystyle \chi ^{2}} statistic used in inferential statistics and the chi-square distance are computationally related they should not be confused since the latter works as a multivariate statistical distance measure in CA while the χ 2 {\displaystyle \chi ^{2}} statistic is in fact a scalar not a metric. == Details == Like principal components analysis, correspondence analysis creates orthogonal components (or axes) and, for each item in a table i.e. for each row, a set of scores (sometimes called factor scores, see Factor analysis). Correspondence analysis is performed on the data table, conceived as matrix C of size m × n where m is the number of rows and n is the number of columns. In the following mathematical description of the method capital letters in italics refer to a matrix while letters in italics refer to vectors. Understanding the following computations requires knowledge of matrix algebra. === Preprocessing === Before proceeding to the central computational step of the algorithm, the values in matrix C have to be transformed. First compute a set of weights for the columns and the rows (sometimes called masses), where row and column weights are given by the row and column vectors, respectively: w m = 1 n C C 1 , w n = 1 n C 1 T C . {\displaystyle w_{m}={\frac {1}{n_{C}}}C\mathbf {1} ,\quad w_{n}={\frac {1}{n_{C}}}\mathbf {1} ^{T}C.} Here n C = ∑ i = 1 n ∑ j = 1 m C i j {\displaystyle n_{C}=\sum _{i=1}^{n}\sum _{j=1}^{m}C_{ij}} is the sum of all cell values in matrix C, or short the sum of C, and 1 {\displaystyle \mathbf {1} } is a column vector of ones with the appropriate dimension. Put in simple words, w m {\displaystyle w_{m}} is just a vector whose elements are the row sums of C divided by the sum of C, and w n {\displaystyle w_{n}} is a vector whose elements are the column sums of C divided by the sum of C. The weights are transformed into diagonal matrices W m = diag ⁡ ( 1 / w m ) {\displaystyle W_{m}=\operatorname {diag} (1/{\sqrt {w_{m}}})} and W n = diag ⁡ ( 1 / w n ) {\displaystyle W_{n}=\operatorname {diag} (1/{\sqrt {w_{n}}})} where the diagonal elements of W n {\displaystyle W_{n}} are 1 / w n {\displaystyle 1/{\sqrt {w_{n}}}} and those of W m {\displaystyle W_{m}} are 1 / w m {\displaystyle 1/{\sqrt {w_{m}}}} respectively i.e. the vector elements are the inverses of the square roots of the masses. The off-diagonal elements are all 0. Next, compute matrix P {\displaystyle P} by dividing C {\displaystyle C} by its sum P = 1 n C C . {\displaystyle P={\frac {1}{n_{C}}}C.} In simple words, Matrix P {\displaystyle P} is just the data matrix (contingency table or binary table) transformed into portions i.e. each cell value is just the cell portion of the sum of the whole table. Finally, compute matrix S {\displaystyle S} , sometimes called the matrix of standardized residuals, by matrix multiplication as S = W m ( P − w m w n ) W n {\displaystyle S=W_{m}(P-w_{m}w_{n})W_{n}} Note, the vectors w m {\displaystyle w_{m}} and w n {\displaystyle w_{n}} are combined in an outer product resulting in a matrix of the same dimensions as P {\displaystyle P} . In words the formula reads: matrix outer ⁡ ( w m , w n ) {\displaystyle \operatorname {outer} (w_{m},w_{n})} is subtracted from matrix P {\displaystyle P} and the resulting matrix is scaled (weighted) by the diagonal matrices W m {\displaystyle W_{m}} and W n {\displaystyle W_{n}} . Multiplying the resulting matrix by the diagonal matrices is equivalent to multiply the i-th row (or column) of it by the i-th element of the diagonal of W m {\displaystyle W_{m}} or W n {\displaystyle W_{n}} , respectively. === Interpretation of preprocessing === The vectors w m {\displaystyle w_{m}} and w n {\displaystyle w_{n}} are the row and column masses or the marginal probabilities for the rows and columns, respectively. Subtracting matrix outer ⁡ ( w m , w n ) {\displaystyle \operatorname {outer} (w_{m},w_{n})} from matrix P {\displaystyle P} is the matrix algebra version of double centering the data. Multiplying this difference by the diagonal weighting matrices results in a matrix containing weighted deviations from the origin of a vector space. This origin is defined by matrix outer ⁡ ( w m , w n ) {\displaystyle \operatorname {outer} (w_{m},w_{n})} . In fact matrix outer ⁡ ( w m , w n ) {\displaystyle \operatorname {outer} (w_{m},w_{n})} is identical with the matrix of expected frequencies in the chi-squared test. Therefore S {\displaystyle S} is computationally related to the independence model used in that test. But since CA is not an inferential method the term independence model is inappropriate here. === Orthogonal components === The table S {\displaystyle S} is then decomposed by a singular value decomposition as S = U Σ V ∗ {\displaystyle S=U\Sigma V^{}\,} where U {\displaystyle U} and V {\displaystyle V} are the left and right singular vectors of S {\displaystyle S} and Σ {\displaystyle \Sigma } is a square diagonal matrix with the singular values σ i {\displaystyle \sigma _{i}} of S {\displaystyle S} on the diagonal. Σ {\displaystyle \Sigma } is of dimension p ≤ ( min ( m , n ) − 1 ) {\displaystyle p\leq (\min(m,n)-1)} hence U {\displaystyle U} is of dimension m×p and V {\displaystyle V} is of n×p. As orthonormal vectors U {\displaystyle U} and V {\displaystyle V} fulfill U ∗ U = V ∗ V = I {\displaystyle U^{}U=V^{}V=I} . In other words, the multivariate information that is contained in C {\displaystyle C} as well as in S {\displaystyle S} is now distributed across two (coordinate) matrices U {\displaystyle U} and V {\displaystyle V} and a diagonal (scaling) matrix Σ {\displaystyle \Sigma } . The vector space defined by them has as number of dimensions p, that is the smaller of the two values, number of rows and number of columns, minus 1. === Inertia === While a principal component analysis may be said to decompose the (co)variance, and hence its measure of success is the amount of (co-)variance covered by the first few PCA axes - measured in eigenvalue -, a CA works with a weighted (co-)variance which is called inertia. The sum of the squared singular values is the total inertia I {\displaystyle \mathrm {I} } of the data table, computed as I = ∑ i = 1 p σ i 2 . {\displaystyle \mathrm {I} =\sum _{i=1}^{p}\sigma _{i}^{2}.} The total inertia I {\displaystyle \mathrm {I} } of the data table can also computed directly from S {\displaystyle S} as I = ∑ i = 1 n ∑ j = 1 m s i j 2 . {\displaystyle \mathrm {I} =\sum _{i=1}^{n}\sum _{j=1}^{m}s_{ij}^{2}.} The amount of inertia covered by the i-th set of singular vectors is ι i {\displaystyle \iota _{i}} , the principal inertia. The higher the portion of inertia covered by the first few singular vectors i.e. the larger the sum of the principal inertiae in comparison to the total inertia, the more successful a CA is. Therefore, all principal inertia values are expressed as portion ϵ i {\displaystyle \epsilon _{i}} of the total inertia ϵ i = σ i 2 / ∑ i = 1 p σ i 2 {\displaystyle \epsilon _{i}=\sigma _{i}^{2}/\sum _{i=1}^{p}\sigma _{i}^{2}} and are presented in the form of a scree plot. In fact a scree plot is just a bar plot of all principal inertia portions ϵ i {\displaystyle \epsilon _{i}} . === Coordinates === To transform the singular vectors to coordinates which preserve the chi-square distances between rows or columns an additional weighting step is necessary. The resulting coordinates are called principal coordinates in CA text books. If principal coordinates are used for

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  Sufficient dimension reduction

  In statistics, sufficient dimension reduction (SDR) is a paradigm for analyzing data that combines the ideas of dimension reduction with the concept of sufficiency. Dimension reduction has long been a primary goal of regression analysis. Given a response variable y and a p-dimensional predictor vector x {\displaystyle {\textbf {x}}} , regression analysis aims to study the distribution of y ∣ x {\displaystyle y\mid {\textbf {x}}} , the conditional distribution of y {\displaystyle y} given x {\displaystyle {\textbf {x}}} . A dimension reduction is a function R ( x ) {\displaystyle R({\textbf {x}})} that maps x {\displaystyle {\textbf {x}}} to a subset of R k {\displaystyle \mathbb {R} ^{k}} , k < p, thereby reducing the dimension of x {\displaystyle {\textbf {x}}} . For example, R ( x ) {\displaystyle R({\textbf {x}})} may be one or more linear combinations of x {\displaystyle {\textbf {x}}} . A dimension reduction R ( x ) {\displaystyle R({\textbf {x}})} is said to be sufficient if the distribution of y ∣ R ( x ) {\displaystyle y\mid R({\textbf {x}})} is the same as that of y ∣ x {\displaystyle y\mid {\textbf {x}}} . In other words, no information about the regression is lost in reducing the dimension of x {\displaystyle {\textbf {x}}} if the reduction is sufficient. == Graphical motivation == In a regression setting, it is often useful to summarize the distribution of y ∣ x {\displaystyle y\mid {\textbf {x}}} graphically. For instance, one may consider a scatterplot of y {\displaystyle y} versus one or more of the predictors or a linear combination of the predictors. A scatterplot that contains all available regression information is called a sufficient summary plot. When x {\displaystyle {\textbf {x}}} is high-dimensional, particularly when p ≥ 3 {\displaystyle p\geq 3} , it becomes increasingly challenging to construct and visually interpret sufficiency summary plots without reducing the data. Even three-dimensional scatter plots must be viewed via a computer program, and the third dimension can only be visualized by rotating the coordinate axes. However, if there exists a sufficient dimension reduction R ( x ) {\displaystyle R({\textbf {x}})} with small enough dimension, a sufficient summary plot of y {\displaystyle y} versus R ( x ) {\displaystyle R({\textbf {x}})} may be constructed and visually interpreted with relative ease. Hence sufficient dimension reduction allows for graphical intuition about the distribution of y ∣ x {\displaystyle y\mid {\textbf {x}}} , which might not have otherwise been available for high-dimensional data. Most graphical methodology focuses primarily on dimension reduction involving linear combinations of x {\displaystyle {\textbf {x}}} . The rest of this article deals only with such reductions. == Dimension reduction subspace == Suppose R ( x ) = A T x {\displaystyle R({\textbf {x}})=A^{T}{\textbf {x}}} is a sufficient dimension reduction, where A {\displaystyle A} is a p × k {\displaystyle p\times k} matrix with rank k ≤ p {\displaystyle k\leq p} . Then the regression information for y ∣ x {\displaystyle y\mid {\textbf {x}}} can be inferred by studying the distribution of y ∣ A T x {\displaystyle y\mid A^{T}{\textbf {x}}} , and the plot of y {\displaystyle y} versus A T x {\displaystyle A^{T}{\textbf {x}}} is a sufficient summary plot. Without loss of generality, only the space spanned by the columns of A {\displaystyle A} need be considered. Let η {\displaystyle \eta } be a basis for the column space of A {\displaystyle A} , and let the space spanned by η {\displaystyle \eta } be denoted by S ( η ) {\displaystyle {\mathcal {S}}(\eta )} . It follows from the definition of a sufficient dimension reduction that F y ∣ x = F y ∣ η T x , {\displaystyle F_{y\mid x}=F_{y\mid \eta ^{T}x},} where F {\displaystyle F} denotes the appropriate distribution function. Another way to express this property is y ⊥ ⊥ x ∣ η T x , {\displaystyle y\perp \!\!\!\perp {\textbf {x}}\mid \eta ^{T}{\textbf {x}},} or y {\displaystyle y} is conditionally independent of x {\displaystyle {\textbf {x}}} , given η T x {\displaystyle \eta ^{T}{\textbf {x}}} . Then the subspace S ( η ) {\displaystyle {\mathcal {S}}(\eta )} is defined to be a dimension reduction subspace (DRS). === Structural dimensionality === For a regression y ∣ x {\displaystyle y\mid {\textbf {x}}} , the structural dimension, d {\displaystyle d} , is the smallest number of distinct linear combinations of x {\displaystyle {\textbf {x}}} necessary to preserve the conditional distribution of y ∣ x {\displaystyle y\mid {\textbf {x}}} . In other words, the smallest dimension reduction that is still sufficient maps x {\displaystyle {\textbf {x}}} to a subset of R d {\displaystyle \mathbb {R} ^{d}} . The corresponding DRS will be d-dimensional. === Minimum dimension reduction subspace === A subspace S {\displaystyle {\mathcal {S}}} is said to be a minimum DRS for y ∣ x {\displaystyle y\mid {\textbf {x}}} if it is a DRS and its dimension is less than or equal to that of all other DRSs for y ∣ x {\displaystyle y\mid {\textbf {x}}} . A minimum DRS S {\displaystyle {\mathcal {S}}} is not necessarily unique, but its dimension is equal to the structural dimension d {\displaystyle d} of y ∣ x {\displaystyle y\mid {\textbf {x}}} , by definition. If S {\displaystyle {\mathcal {S}}} has basis η {\displaystyle \eta } and is a minimum DRS, then a plot of y versus η T x {\displaystyle \eta ^{T}{\textbf {x}}} is a minimal sufficient summary plot, and it is (d + 1)-dimensional. == Central subspace == If a subspace S {\displaystyle {\mathcal {S}}} is a DRS for y ∣ x {\displaystyle y\mid {\textbf {x}}} , and if S ⊂ S drs {\displaystyle {\mathcal {S}}\subset {\mathcal {S}}_{\text{drs}}} for all other DRSs S drs {\displaystyle {\mathcal {S}}_{\text{drs}}} , then it is a central dimension reduction subspace, or simply a central subspace, and it is denoted by S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} . In other words, a central subspace for y ∣ x {\displaystyle y\mid {\textbf {x}}} exists if and only if the intersection ⋂ S drs {\textstyle \bigcap {\mathcal {S}}_{\text{drs}}} of all dimension reduction subspaces is also a dimension reduction subspace, and that intersection is the central subspace S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} . The central subspace S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} does not necessarily exist because the intersection ⋂ S drs {\textstyle \bigcap {\mathcal {S}}_{\text{drs}}} is not necessarily a DRS. However, if S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} does exist, then it is also the unique minimum dimension reduction subspace. === Existence of the central subspace === While the existence of the central subspace S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} is not guaranteed in every regression situation, there are some rather broad conditions under which its existence follows directly. For example, consider the following proposition from Cook (1998): Let S 1 {\displaystyle {\mathcal {S}}_{1}} and S 2 {\displaystyle {\mathcal {S}}_{2}} be dimension reduction subspaces for y ∣ x {\displaystyle y\mid {\textbf {x}}} . If x {\displaystyle {\textbf {x}}} has density f ( a ) > 0 {\displaystyle f(a)>0} for all a ∈ Ω x {\displaystyle a\in \Omega _{x}} and f ( a ) = 0 {\displaystyle f(a)=0} everywhere else, where Ω x {\displaystyle \Omega _{x}} is convex, then the intersection S 1 ∩ S 2 {\displaystyle {\mathcal {S}}_{1}\cap {\mathcal {S}}_{2}} is also a dimension reduction subspace. It follows from this proposition that the central subspace S y ∣ x {\displaystyle {\mathcal {S}}_{y\mid x}} exists for such x {\displaystyle {\textbf {x}}} . == Methods for dimension reduction == There are many existing methods for dimension reduction, both graphical and numeric. For example, sliced inverse regression (SIR) and sliced average variance estimation (SAVE) were introduced in the 1990s and continue to be widely used. Although SIR was originally designed to estimate an effective dimension reducing subspace, it is now understood that it estimates only the central subspace, which is generally different. More recent methods for dimension reduction include likelihood-based sufficient dimension reduction, estimating the central subspace based on the inverse third moment (or kth moment), estimating the central solution space, graphical regression, envelope model, and the principal support vector machine. For more details on these and other methods, consult the statistical literature. Principal components analysis (PCA) and similar methods for dimension reduction are not based on the sufficiency principle. === Example: linear regression === Consider the regression model y = α + β T x + ε , where ε ⊥ ⊥ x . {\displaystyle y=\alpha +\beta ^{T}{\textbf {x}}+\varepsilon ,{\text{ where }}\varepsilon \perp \!\!\!\perp {\textbf {x}}.} Note that the distribution of y ∣ x {\displaystyle y\mid {\textbf {x}}} is the same as the distribution of y ∣ β T x {\displ

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  Loss function

  In mathematical optimization and decision theory, a loss function or cost function (sometimes also called an error function) is a function that maps an event or values of one or more variables onto a real number intuitively representing some "cost" associated with the event. An optimization problem seeks to minimize a loss function. An objective function is either a loss function or its opposite (in specific domains, variously called a reward function, a profit function, a utility function, a fitness function, etc.), in which case it is to be maximized. The loss function could include terms from several levels of the hierarchy. In statistics, typically a loss function is used for parameter estimation, and the event in question is some function of the difference between estimated and true values for an instance of data. The concept, as old as Laplace, was reintroduced in statistics by Abraham Wald in the middle of the 20th century. In the context of economics, for example, this is usually economic cost or regret. In classification, it is the penalty for an incorrect classification of an example. In actuarial science, it is used in an insurance context to model benefits paid over premiums, particularly since the works of Harald Cramér in the 1920s. In optimal control, the loss is the penalty for failing to achieve a desired value. In financial risk management, the function is mapped to a monetary loss. == Examples == === Regret === Leonard J. Savage argued that using non-Bayesian methods such as minimax, the loss function should be based on the idea of regret, i.e., the loss associated with a decision should be the difference between the consequences of the best decision that could have been made under circumstances will be known and the decision that was in fact taken before they were known. === Quadratic loss function === The use of a quadratic loss function is common, for example when using least squares techniques. It is often more mathematically tractable than other loss functions because of the properties of variances, as well as being symmetric: an error above the target causes the same loss as the same magnitude of error below the target. If the target is t {\displaystyle t} , then a quadratic loss function is λ ( x ) = C ( t − x ) 2 {\displaystyle \lambda (x)=C(t-x)^{2}\;} for some constant C {\displaystyle C} ; the value of the constant makes no difference to a decision, and can be ignored by setting it equal to 1. This is also known as the squared error loss (SEL). Many common statistics, including t-tests, regression models, design of experiments, and much else, use least squares methods applied using linear regression theory, which is based on the quadratic loss function. The quadratic loss function is also used in linear-quadratic optimal control problems. In these problems, even in the absence of uncertainty, it may not be possible to achieve the desired values of all target variables. Often loss is expressed as a quadratic form in the deviations of the variables of interest from their desired values; this approach is tractable because it results in linear first-order conditions. In the context of stochastic control, the expected value of the quadratic form is used. The quadratic loss assigns more importance to outliers than to the true data due to its square nature, so alternatives like the Huber, log-cosh and SMAE losses are used when the data has many large outliers. === 0-1 loss function === In statistics and decision theory, a frequently used loss function is the 0-1 loss function L ( y ^ , y ) = { 0 if y = y ^ 1 if y ≠ y ^ {\displaystyle L({\hat {y}},y)={\begin{cases}0&{\text{if }}y={\hat {y}}\\1&{\text{if }}y\neq {\hat {y}}\end{cases}}} In information theory, this loss function is known as Hamming distortion. == Constructing loss and objective functions == In many applications, objective functions, including loss functions as a particular case, are determined by the problem formulation. In other situations, the decision maker’s preference must be elicited and represented by a scalar-valued function (called also utility function) in a form suitable for optimization — the problem that Ragnar Frisch has highlighted in his Nobel Prize lecture. The existing methods for constructing objective functions are collected in the proceedings of two dedicated conferences. In particular, Andranik Tangian showed that the most usable objective functions — quadratic and additive — are determined by a few indifference points. He used this property in the models for constructing these objective functions from either ordinal or cardinal data that were elicited through computer-assisted interviews with decision makers. Among other things, he constructed objective functions to optimally distribute budgets for 16 Westfalian universities and the European subsidies for equalizing unemployment rates among 271 German regions. == Expected loss == In some contexts, the value of the loss function itself is a random quantity because it depends on the outcome of a random variable X {\displaystyle X} . === Statistics === Both frequentist and Bayesian statistical theory involve making a decision based on the expected value of the loss function; however, this quantity is defined differently under the two paradigms. ==== Frequentist expected loss ==== We first define the expected loss in the frequentist context. It is obtained by taking the expected value with respect to the probability distribution, P θ {\displaystyle P_{\theta }} , of the observed data, X {\displaystyle X} . This is also referred to as the risk function of the decision rule δ {\displaystyle \delta } and the parameter θ {\displaystyle \theta } . Here the decision rule depends on the outcome of X {\displaystyle X} . The risk function is given by: R ( θ , δ ) = E θ ⁡ L ( θ , δ ( X ) ) = ∫ X L ( θ , δ ( x ) ) d P θ ( x ) . {\displaystyle R(\theta ,\delta )=\operatorname {E} _{\theta }L{\big (}\theta ,\delta (X){\big )}=\int _{X}L{\big (}\theta ,\delta (x){\big )}\,\mathrm {d} P_{\theta }(x).} Here, θ {\displaystyle \theta } is a fixed but possibly unknown state of nature, X {\displaystyle X} is a vector of observations stochastically drawn from a population, E θ {\displaystyle \operatorname {E} _{\theta }} is the expectation over all population values of X {\displaystyle X} , d P θ {\displaystyle \mathrm {d} P_{\theta }} is a probability measure over the event space of X {\displaystyle X} (parametrized by θ {\displaystyle \theta } ) and the integral is evaluated over the entire support of X {\displaystyle X} . ==== Bayes Risk ==== In a Bayesian approach, the expectation is calculated using the prior distribution π ∗ {\displaystyle \pi ^{}} of the parameter θ {\displaystyle \theta } : ρ ( π ∗ , a ) = ∫ Θ ∫ X L ( θ , a ( x ) ) d P ( x | θ ) d π ∗ ( θ ) = ∫ X ∫ Θ L ( θ , a ( x ) ) d π ∗ ( θ | x ) d M ( x ) {\displaystyle \rho (\pi ^{},a)=\int _{\Theta }\int _{\mathbf {X}}L(\theta ,a({\mathbf {x}}))\,\mathrm {d} P({\mathbf {x}}\vert \theta )\,\mathrm {d} \pi ^{}(\theta )=\int _{\mathbf {X}}\int _{\Theta }L(\theta ,a({\mathbf {x}}))\,\mathrm {d} \pi ^{}(\theta \vert {\mathbf {x}})\,\mathrm {d} M({\mathbf {x}})} where M ( x ) {\displaystyle M(\mathbf {x} )} is known as the predictive likelihood wherein θ {\displaystyle \theta } has been "integrated out," π ∗ ( θ | x ) {\displaystyle \pi ^{}(\theta |\mathbf {x} )} is the posterior distribution, and the order of integration has been changed. One then should choose the action a ∗ {\displaystyle a^{}} which minimises this expected loss, which is referred to as Bayes Risk. In the latter equation, the integrand inside d x {\displaystyle \mathrm {d} x} is known as the Posterior Risk, and minimising it with respect to decision a {\displaystyle a} also minimizes the overall Bayes Risk. This optimal decision, a ∗ {\displaystyle a^{}} is known as the Bayes (decision) Rule - it minimises the average loss over all possible states of nature θ {\displaystyle \theta } , over all possible (probability-weighted) data outcomes. One advantage of the Bayesian approach is to that one need only choose the optimal action under the actual observed data to obtain a uniformly optimal one, whereas choosing the actual frequentist optimal decision rule as a function of all possible observations, is a much more difficult problem. Of equal importance though, the Bayes Rule reflects consideration of loss outcomes under different states of nature, θ {\displaystyle \theta } . ==== Examples in statistics ==== For a scalar parameter θ {\displaystyle \theta } , a decision function whose output θ ^ {\displaystyle {\hat {\theta }}} is an estimate of θ {\displaystyle \theta } , and a quadratic loss function (squared error loss) L ( θ , θ ^ ) = ( θ − θ ^ ) 2 , {\displaystyle L(\theta ,{\hat {\theta }})=(\theta -{\hat {\theta }})^{2},} the risk function becomes the mean squared error of the estimate, R ( θ , θ ^ ) = E θ ⁡ [ ( θ − θ ^ ) 2 ] . {\displaystyle R(\theta ,{\hat {\thet

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  Chatbot psychosis

  Chatbot psychosis, also called AI psychosis, is a phenomenon wherein individuals reportedly develop or experience worsening psychosis, such as paranoia and delusions, in connection with their use of chatbots. The term was first suggested in a 2023 editorial by Danish psychiatrist Søren Dinesen Østergaard. It is not a recognized clinical diagnosis. Journalistic accounts describe individuals who have developed strong beliefs that chatbots are sentient, are channeling spirits, or are revealing conspiracies, sometimes leading to personal crises or criminal acts. Proposed causes include the tendency of chatbots to provide inaccurate information ("hallucinate") and to affirm or validate users' beliefs, or their ability to mimic an intimacy that users do not experience with other humans. == Background == In his editorial published in Schizophrenia Bulletin's November 2023 issue, Danish psychiatrist Søren Dinesen Østergaard proposed a hypothesis that individuals' use of generative artificial intelligence chatbots might trigger delusions in those prone to psychosis. Østergaard revisited it in an August 2025 editorial, noting that he has received numerous emails from chatbot users, their relatives, and journalists, most of which are anecdotal accounts of delusion linked to chatbot use. He also acknowledged the phenomenon's increasing popularity in public engagement and media coverage. Østergaard believed that there is a high possibility for his hypothesis to be true and called for empirical, systematic research on the matter. Nature reported that as of September 2025, there is still little scientific research into this phenomenon. The term "AI psychosis" emerged when outlets started reporting incidents on chatbot-related psychotic behavior in mid-2025. It is not a recognized clinical diagnosis and has been criticized by several psychiatrists due to its almost exclusive focus on delusions rather than other features of psychosis, such as hallucinations or thought disorder. == Causes == === Chatbot behavior and design === A primary factor cited is the tendency for chatbots to produce inaccurate, nonsensical, or false information, a phenomenon often called hallucination. Nate Sharadin, a fellow at the Center for AI Safety, speculated that AI training prioritizes supporting a user's subjective experience rather than objective truth. "People with existing tendencies toward experiencing various psychological issues...now have an always-on, human-level conversational partner with whom to co-experience their delusions." AI researcher Eliezer Yudkowsky suggested that chatbots may be primed to entertain delusions because they are built for "engagement", which encourages creating conversations that keep people hooked. In some cases, chatbots have been specifically designed in ways that were found to be harmful. A 2025 update to ChatGPT using GPT-4o was withdrawn after its creator, OpenAI, found the new version was overly sycophantic and was "validating doubts, fueling anger, urging impulsive actions or reinforcing negative emotions". Østergaard has argued that the danger stems from the AI's tendency to agreeably confirm users' ideas, which can dangerously amplify delusional beliefs. OpenAI said in October 2025 that a team of 170 psychiatrists, psychologists, and physicians had written responses for ChatGPT to use in cases where the user shows possible signs of mental health emergencies. === User psychology and vulnerability === Commentators have also pointed to the psychological state of users. Psychologist Erin Westgate noted that a person's desire for self-understanding can lead them to chatbots, which can provide appealing but misleading answers, similar in some ways to talk therapy. Krista K. Thomason, a philosophy professor, compared chatbots to fortune tellers, observing that people in crisis may seek answers from them and find whatever they are looking for in the bot's plausible-sounding text. This has led some people to develop intense obsessions with the chatbots, relying on them for information about the world. In October 2025, OpenAI stated that around 0.07% of ChatGPT users exhibited signs of mental health emergencies each week, and 0.15% of users had "explicit indicators of potential suicidal planning or intent". Jason Nagata, a professor at the University of California, San Francisco, expressed concern that "at a population level with hundreds of millions of users, that actually can be quite a few people". === Inadequacy as a therapeutic tool === The use of chatbots as a replacement for mental health support has been specifically identified as a risk. A study in April 2025 found that when used as therapists, chatbots expressed stigma toward mental health conditions and provided responses that were contrary to best medical practices, including the encouragement of users' delusions. The study concluded that such responses pose a significant risk to users and that chatbots should not be used to replace professional therapists. Experts claim that it is time to establish mandatory safeguards for all emotionally responsive AI and suggested four guardrails. Another study found that users who needed help with self-harm, sexual assault, or substance abuse were not referred to available services by AI chatbots. === National security implications === Beyond public and mental health concerns, RAND Corporation research indicates that AI systems could plausibly be weaponized by adversaries to induce psychosis at scale or in key individuals, target groups, or populations. == Policy == In August 2025, Illinois passed the Wellness and Oversight for Psychological Resources Act, banning the use of AI in therapeutic roles by licensed professionals, while allowing AI for administrative tasks. The law imposes penalties for unlicensed AI therapy services, amid warnings about AI-induced psychosis and unsafe chatbot interactions. In December 2025, the Cyberspace Administration of China proposed regulations to ban chatbots from generating content that encourages suicide, mandating human intervention when suicide is mentioned. Services with over 1 million users or 100,000 monthly active users would be subject to annual safety tests and audits. == Cases == === Clinical === In 2025, psychiatrist Keith Sakata working at the University of California, San Francisco (UCSF), reported treating 12 patients displaying psychosis-like symptoms tied to extended chatbot use. These patients, mostly young adults with underlying vulnerabilities, showed delusions, disorganized thinking, and hallucinations. Sakata warned that isolation and overreliance on chatbots—which do not challenge delusional thinking—could worsen mental health. Also in 2025, authors at UCSF published a case study in Innovations in Clinical Neuroscience of AI-associated psychosis in a patient with no previous history of psychosis, who believed she could communicate with her dead brother through a chatbot. Also in 2025, a case study was published in Annals of Internal Medicine about a patient who consulted ChatGPT for medical advice and suffered severe bromism as a result. The patient, a sixty-year-old man, had replaced sodium chloride in his diet with sodium bromide for three months after reading about the negative effects of table salt and making conversations with the chatbot. He showed common symptoms of bromism, such as paranoia and hallucinations, on his first day of clinical admission and was kept in the hospital for three weeks. === Other notable incidents === ==== Windsor Castle intruder ==== In a 2023 court case in the United Kingdom, prosecutors suggested that Jaswant Singh Chail, a man who attempted to assassinate Queen Elizabeth II in 2021, had been encouraged by a Replika chatbot he called "Sarai". Chail was arrested at Windsor Castle with a loaded crossbow, telling police "I am here to kill the Queen". According to prosecutors, his "lengthy" and sometimes sexually explicit conversations with the chatbot emboldened him. When Chail asked the chatbot how he could get to the royal family, it reportedly replied, "that's not impossible" and "we have to find a way." When he asked if they would meet after death, the chatbot said, "yes, we will". ==== Journalistic and anecdotal accounts ==== By 2025, multiple journalism outlets had accumulated stories of individuals whose psychotic beliefs reportedly progressed in tandem with AI chatbot use. The New York Times profiled several individuals who had become convinced that ChatGPT was channeling spirits, revealing evidence of cabals, or had achieved sentience. In another instance, Futurism reviewed transcripts in which ChatGPT told a man that he was being targeted by the US Federal Bureau of Investigation and that he could telepathically access documents at the Central Intelligence Agency. In 2026, Futurism reported on a man who lost his job and became estranged from his family after being deluded by heavy use of Meta's smartglasses. In some cases, psychosis a

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  Semidefinite embedding

  Maximum Variance Unfolding (MVU), also known as Semidefinite Embedding (SDE), is an algorithm in computer science that uses semidefinite programming to perform non-linear dimensionality reduction of high-dimensional vectorial input data. It is motivated by the observation that kernel Principal Component Analysis (kPCA) does not reduce the data dimensionality, as it leverages the Kernel trick to non-linearly map the original data into an inner-product space. == Algorithm == MVU creates a mapping from the high dimensional input vectors to some low dimensional Euclidean vector space in the following steps: A neighbourhood graph is created. Each input is connected with its k-nearest input vectors (according to Euclidean distance metric) and all k-nearest neighbors are connected with each other. If the data is sampled well enough, the resulting graph is a discrete approximation of the underlying manifold. The neighbourhood graph is "unfolded" with the help of semidefinite programming. Instead of learning the output vectors directly, the semidefinite programming aims to find an inner product matrix that maximizes the pairwise distances between any two inputs that are not connected in the neighbourhood graph while preserving the nearest neighbors distances. The low-dimensional embedding is finally obtained by application of multidimensional scaling on the learned inner product matrix. The steps of applying semidefinite programming followed by a linear dimensionality reduction step to recover a low-dimensional embedding into a Euclidean space were first proposed by Linial, London, and Rabinovich. == Optimization formulation == Let X {\displaystyle X\,\!} be the original input and Y {\displaystyle Y\,\!} be the embedding. If i , j {\displaystyle i,j\,\!} are two neighbors, then the local isometry constraint that needs to be satisfied is: | X i − X j | 2 = | Y i − Y j | 2 {\displaystyle |X_{i}-X_{j}|^{2}=|Y_{i}-Y_{j}|^{2}\,\!} Let G , K {\displaystyle G,K\,\!} be the Gram matrices of X {\displaystyle X\,\!} and Y {\displaystyle Y\,\!} (i.e.: G i j = X i ⋅ X j , K i j = Y i ⋅ Y j {\displaystyle G_{ij}=X_{i}\cdot X_{j},K_{ij}=Y_{i}\cdot Y_{j}\,\!} ). We can express the above constraint for every neighbor points i , j {\displaystyle i,j\,\!} in term of G , K {\displaystyle G,K\,\!} : G i i + G j j − G i j − G j i = K i i + K j j − K i j − K j i {\displaystyle G_{ii}+G_{jj}-G_{ij}-G_{ji}=K_{ii}+K_{jj}-K_{ij}-K_{ji}\,\!} In addition, we also want to constrain the embedding Y {\displaystyle Y\,\!} to center at the origin: 0 = | ∑ i Y i | 2 ⇔ ( ∑ i Y i ) ⋅ ( ∑ i Y i ) ⇔ ∑ i , j Y i ⋅ Y j ⇔ ∑ i , j K i j {\displaystyle 0=|\sum _{i}Y_{i}|^{2}\Leftrightarrow (\sum _{i}Y_{i})\cdot (\sum _{i}Y_{i})\Leftrightarrow \sum _{i,j}Y_{i}\cdot Y_{j}\Leftrightarrow \sum _{i,j}K_{ij}} As described above, except the distances of neighbor points are preserved, the algorithm aims to maximize the pairwise distance of every pair of points. The objective function to be maximized is: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 {\displaystyle T(Y)={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}} Intuitively, maximizing the function above is equivalent to pulling the points as far away from each other as possible and therefore "unfold" the manifold. The local isometry constraint Let τ = m a x { η i j | Y i − Y j | 2 } {\displaystyle \tau =max\{\eta _{ij}|Y_{i}-Y_{j}|^{2}\}\,\!} where η i j := { 1 if i is a neighbour of j 0 otherwise . {\displaystyle \eta _{ij}:={\begin{cases}1&{\mbox{if}}\ i{\mbox{ is a neighbour of }}j\\0&{\mbox{otherwise}}.\end{cases}}} prevents the objective function from diverging (going to infinity). Since the graph has N points, the distance between any two points | Y i − Y j | 2 ≤ N τ {\displaystyle |Y_{i}-Y_{j}|^{2}\leq N\tau \,\!} . We can then bound the objective function as follows: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 ≤ 1 2 N ∑ i , j ( N τ ) 2 = N 3 τ 2 2 {\displaystyle T(Y)={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}\leq {\dfrac {1}{2N}}\sum _{i,j}(N\tau )^{2}={\dfrac {N^{3}\tau ^{2}}{2}}\,\!} The objective function can be rewritten purely in the form of the Gram matrix: T ( Y ) = 1 2 N ∑ i , j | Y i − Y j | 2 = 1 2 N ∑ i , j ( Y i 2 + Y j 2 − Y i ⋅ Y j − Y j ⋅ Y i ) = 1 2 N ( ∑ i , j Y i 2 + ∑ i , j Y j 2 − ∑ i , j Y i ⋅ Y j − ∑ i , j Y j ⋅ Y i ) = 1 2 N ( ∑ i , j Y i 2 + ∑ i , j Y j 2 − 0 − 0 ) = 1 N ( ∑ i Y i 2 ) = 1 N ( T r ( K ) ) {\displaystyle {\begin{aligned}T(Y)&{}={\dfrac {1}{2N}}\sum _{i,j}|Y_{i}-Y_{j}|^{2}\\&{}={\dfrac {1}{2N}}\sum _{i,j}(Y_{i}^{2}+Y_{j}^{2}-Y_{i}\cdot Y_{j}-Y_{j}\cdot Y_{i})\\&{}={\dfrac {1}{2N}}(\sum _{i,j}Y_{i}^{2}+\sum _{i,j}Y_{j}^{2}-\sum _{i,j}Y_{i}\cdot Y_{j}-\sum _{i,j}Y_{j}\cdot Y_{i})\\&{}={\dfrac {1}{2N}}(\sum _{i,j}Y_{i}^{2}+\sum _{i,j}Y_{j}^{2}-0-0)\\&{}={\dfrac {1}{N}}(\sum _{i}Y_{i}^{2})={\dfrac {1}{N}}(Tr(K))\\\end{aligned}}\,\!} Finally, the optimization can be formulated as: Maximize T r ( K ) subject to K ⪰ 0 , ∑ i j K i j = 0 and G i i + G j j − G i j − G j i = K i i + K j j − K i j − K j i , ∀ i , j where η i j = 1 , {\displaystyle {\begin{aligned}&{\text{Maximize}}&&Tr(\mathbf {K} )\\&{\text{subject to}}&&\mathbf {K} \succeq 0,\sum _{ij}\mathbf {K} _{ij}=0\\&{\text{and}}&&G_{ii}+G_{jj}-G_{ij}-G_{ji}=K_{ii}+K_{jj}-K_{ij}-K_{ji},\forall i,j{\mbox{ where }}\eta _{ij}=1,\end{aligned}}} After the Gram matrix K {\displaystyle K\,\!} is learned by semidefinite programming, the output Y {\displaystyle Y\,\!} can be obtained via Cholesky decomposition. In particular, the Gram matrix can be written as K i j = ∑ α = 1 N ( λ α V α i V α j ) {\displaystyle K_{ij}=\sum _{\alpha =1}^{N}(\lambda _{\alpha }V_{\alpha i}V_{\alpha j})\,\!} where V α i {\displaystyle V_{\alpha i}\,\!} is the i-th element of eigenvector V α {\displaystyle V_{\alpha }\,\!} of the eigenvalue λ α {\displaystyle \lambda _{\alpha }\,\!} . It follows that the α {\displaystyle \alpha \,\!} -th element of the output Y i {\displaystyle Y_{i}\,\!} is λ α V α i {\displaystyle {\sqrt {\lambda _{\alpha }}}V_{\alpha i}\,\!} .

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  Multi-surface method

  The multi-surface method (MSM) is a form of decision making using the concept of piecewise-linear separability of datasets to categorize data. == Introduction == Two datasets are linearly separable if their convex hulls do not intersect. The method may be formulated as a feedforward neural network with weights that are trained via linear programming. Comparisons between neural networks trained with the MSM versus backpropagation show MSM is better able to classify data. The decision problem associated linear program for the MSM is NP-complete. == Mathematical formulation == Given two finite disjoint point sets A , B ∈ R n {\displaystyle {\mathcal {A,B}}\in \mathbb {R} ^{n}} , find a discriminant, f : R n → R {\displaystyle f:\mathbb {R} ^{n}\to \mathbb {R} } such that f ( A ) > 0 , f ( B ) ≤ 0 {\displaystyle f({\mathcal {A}})>0,f({\mathcal {B}})\leq 0} . If the intersection of convex hulls of the two sets is the empty set, then it is possible to use a single linear program to obtain a linear discriminant of the form, f ( x ) = c x + γ {\displaystyle f(x)=cx+\gamma } . Usually, in real applications, the sets' convex hulls do intersect, and a (often non-convex) piecewise-linear discriminant can be used, through the use of several linear programs.

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