AI App Gemini

AI App Gemini — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

Artipic

Artipic is a graphics editor developed for Microsoft Windows. An older version for macOS is still available but unsupported. Artipic features drawing, editing, retouching, transforming and composing images including color corrections, effects and layer-based operations. It converts all common image formats and imports camera raw formats. In the global image editing ecosystem Artipic can be positioned somewhere in the middle. It differs from simple free photo editors by more advanced capabilities, however it does not cover the complete professional-level functionality pack provided by industry leaders like Adobe Photoshop. == History == Artipic developed by Swedish company Artipic AB. Artipic 1.0 was released in March 2014 as a free version. The first commercial version on Microsoft Windows was released in November 2014, on macOS – in October 2015. == Features == Supports Microsoft Windows and macOS Standard tools: select, crop, move, rotate, transform, stamp, color picking, text Advanced tools: custom brushes, gradients, shapes, paths, layers and masks Special tools: healing brush, red-eye effect reduction, dodge and burn brushes Adjustments: Brightness & Contrast, Hue & Saturation, Curves, Levels, Color Balance, Gamma Correction, Exposure, Color Temperature, Tint, Color Enhancer, Photo Filter Simulation, Posterization, Thresholding Filters: Smoothen, Sharpen, Vignetting, High-pass, Diffuse Glow, Shadow, Gaussian Blur Reversible (non-destructive) stylization presets Batch processing White balance RAW-converter including Gray Card Adobe Photoshop images supported == Version history ==
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Targeted maximum likelihood estimation

Targeted Maximum Likelihood Estimation (TMLE) (also more accurately referred to as Targeted Minimum Loss-Based Estimation) is a general statistical estimation framework for causal inference and semiparametric models. TMLE combines ideas from maximum likelihood estimation, semiparametric efficiency theory, and machine learning. It was introduced by Mark J. van der Laan and colleagues in the mid-2000s as a method that yields asymptotically efficient plug-in estimators while allowing the use of flexible, data-adaptive algorithms such as ensemble machine learning for nuisance parameter estimation. TMLE is used in epidemiology, biostatistics, and the social sciences to estimate causal effects in observational and experimental studies. Applications of TMLE include Longitudinal TMLE (LTMLE) for time-varying treatments and confounders. Variations in how the targeting step in TMLE is carried out have resulted in various versions of TMLE such as Collaborative TMLE (CTMLE) and Adaptive TMLE for improved finite-sample performance and automated variable selection. == History == The TMLE framework was first described by van der Laan and Rubin (2006) as a general approach for the construction of efficient plug-in estimators of smooth features of the data density. It was demonstrated in the context of causal inference and missing data problems. It was developed to address limitations of traditional doubly robust methods, such as Augmented Inverse Probability Weighting (AIPW), by respecting the plug-in principle in the sense that it respects that the target parameter is a function of the data density that is an element of the statistical model. TMLE estimates the data density or relevant parts of it with machine learning and targets these machine learning fits before it is plugged in the target parameter mapping. In this manner, a TMLE always respects global knowledge and satisfies known bounds such as that the target parameter is a probability . Since its introduction, TMLE has been developed in a series of theoretical and applied papers, culminating in book-length treatments of the method and its applications to survival analysis, adaptive designs, and longitudinal data. == Methodology == At its core, TMLE is a two-step estimation procedure: Initial estimation: Machine learning methods (such as the Super Learner ensemble) are used to obtain flexible estimates of nuisance parameters, such as outcome regressions and propensity scores. Targeting step: The initial estimate is updated by solving a score equation (the efficient influence function) so that the final estimator is consistent, asymptotically normal, and efficient under mild regularity conditions. The targeted machine learning fit is then mapped into the corresponding estimator of the target parameter by simply plugging it in the target parameter mapping. This approach balances the bias–variance trade-off by combining data-adaptive estimation with semiparametric efficiency theory. TMLE is doubly robust, meaning it remains consistent if either the outcome model or the treatment model is consistently estimated. === Formula === Here we explain the TMLE of the average treatment effect of a binary treatment on an outcome adjusting for baseline covariates. Consider i.i.d. observations O i = ( W i , A i , Y i ) {\displaystyle O_{i}=(W_{i},A_{i},Y_{i})} from a distribution P 0 {\displaystyle P_{0}} , where W {\displaystyle W} are baseline covariates, A {\displaystyle A} is a binary treatment, and Y {\displaystyle Y} is an outcome. Let Q ¯ ( a , w ) = E [ Y ∣ A = a , W = w ] {\displaystyle {\bar {Q}}(a,w)=\mathbb {E} [Y\mid A=a,W=w]} represent the outcome model and g ( a ∣ w ) = P ( A = a ∣ W = w ) {\displaystyle g(a\mid w)=P(A=a\mid W=w)} represent the propensity score. The average treatment effect (ATE) is given by ψ 0 = E { Q ¯ ( 1 , W ) − Q ¯ ( 0 , W ) } . {\displaystyle \psi _{0}=\mathbb {E} \{{\bar {Q}}(1,W)-{\bar {Q}}(0,W)\}.} A basic TMLE for the ATE proceeds as follows: Step 1: Estimate initial models. Obtain estimates Q ¯ ^ ( a , w ) {\displaystyle {\hat {\bar {Q}}}(a,w)} and g ^ ( a ∣ w ) {\displaystyle {\hat {g}}(a\mid w)} , often using flexible methods such as Super Learner. Step 2: Compute the clever covariate. Define: H ( A , W ) = A g ^ ( 1 ∣ W ) − 1 − A g ^ ( 0 ∣ W ) . {\displaystyle H(A,W)={\frac {A}{{\hat {g}}(1\mid W)}}-{\frac {1-A}{{\hat {g}}(0\mid W)}}.} Step 3: Estimate the fluctuation parameter. Fit a logistic regression of Y {\displaystyle Y} on H ( A , W ) {\displaystyle H(A,W)} with logit ⁡ ( Q ¯ ^ ( A , W ) ) {\displaystyle \operatorname {logit} ({\hat {\bar {Q}}}(A,W))} as offset. This yields ε ^ {\displaystyle {\hat {\varepsilon }}} , the MLE that solves the score equation: 1 n ∑ i = 1 n H ( A i , W i ) { Y i − Q ¯ ^ ε ( A i , W i ) } = 0. {\displaystyle {\frac {1}{n}}\sum _{i=1}^{n}H(A_{i},W_{i}){\big \{}Y_{i}-{\hat {\bar {Q}}}^{\varepsilon }(A_{i},W_{i}){\big \}}=0.} Step 4: Update the initial estimate. Apply the "blip" to obtain the targeted estimate: Q ¯ ^ ∗ ( A , W ) = expit ⁡ ( logit ⁡ ( Q ¯ ^ ( A , W ) ) + ε ^ H ( A , W ) ) . {\displaystyle {\hat {\bar {Q}}}^{}(A,W)=\operatorname {expit} {\Big (}\operatorname {logit} {\big (}{\hat {\bar {Q}}}(A,W){\big )}+{\hat {\varepsilon }}\,H(A,W){\Big )}.} Step 5: Compute the TMLE. The ATE estimate is: ψ ^ TMLE = 1 n ∑ i = 1 n [ Q ¯ ^ ∗ ( 1 , W i ) − Q ¯ ^ ∗ ( 0 , W i ) ] . {\displaystyle {\hat {\psi }}_{\text{TMLE}}={\frac {1}{n}}\sum _{i=1}^{n}{\big [}{\hat {\bar {Q}}}^{}(1,W_{i})-{\hat {\bar {Q}}}^{}(0,W_{i}){\big ]}.} Inference. The efficient influence function (EIF) for the ATE is: D ∗ ( O ) = H ( A , W ) { Y − Q ¯ ∗ ( A , W ) } + Q ¯ ∗ ( 1 , W ) − Q ¯ ∗ ( 0 , W ) − ψ . {\displaystyle D^{}(O)=H(A,W)\{Y-{\bar {Q}}^{}(A,W)\}+{\bar {Q}}^{}(1,W)-{\bar {Q}}^{}(0,W)-\psi .} The variance is estimated by σ ^ 2 = n − 1 ∑ i = 1 n ( D ∗ ( O i ) ) 2 {\displaystyle {\hat {\sigma }}^{2}=n^{-1}\sum _{i=1}^{n}{\big (}D^{}(O_{i}){\big )}^{2}} , yielding Wald-type confidence intervals ψ ^ TMLE ± z 1 − α / 2 σ ^ / n {\displaystyle {\hat {\psi }}_{\text{TMLE}}\pm z_{1-\alpha /2}\,{\hat {\sigma }}/{\sqrt {n}}} . Remark. For continuous outcomes, a linear fluctuation Q ¯ ^ ∗ = Q ¯ ^ + ε ^ H {\displaystyle {\hat {\bar {Q}}}^{}={\hat {\bar {Q}}}+{\hat {\varepsilon }}\,H} may be used instead. For bounded continuous outcomes, the logistic fluctuation (after rescaling Y {\displaystyle Y} to [ 0 , 1 ] {\displaystyle [0,1]} ) is often preferred for improved finite-sample performance. == Applications == TMLE has been applied in: Epidemiology: Estimating causal effects of exposures and interventions in observational cohort studies. Clinical trials and real-world evidence: The Targeted Learning roadmap provides a structured framework for generating and validating real-world evidence (RWE), bridging randomized trials and observational data using TMLE and related estimation techniques. This approach enables transparency, sensitivity analysis, and stronger causal inference for regulatory and clinical trial contexts. High-dimensional settings: Integration with ensemble methods for causal effect estimation. TMLE has been successfully applied in pharmacoepidemiology where a large number of covariates are automatically selected to adjust for confounding. In a study of post–myocardial infarction statin use and 1-year mortality, TMLE demonstrated robust performance relative to inverse probability weighting in scenarios with hundreds of potential confounders. == Derivatives and extensions == Longitudinal TMLE (LTMLE): A methodological extension of TMLE for longitudinal data with time-varying treatments, confounders, and censoring. It allows the estimation of dynamic treatment regimes and intervention-specific causal effects over time. This framework was originally introduced by van der Laan & Gruber (2012). Collaborative TMLE (CTMLE): Enhances finite-sample performance and variable selection by collaboratively fitting the treatment mechanism in conjunction with the target parameter. == Software == Several R packages implement TMLE and related methods: tmle: Functions for binary, categorical, and continuous outcomes. ltmle: Implementation for longitudinal data with time-varying treatments and outcomes. ctmle: Algorithms for collaborative TMLE and adaptive variable selection. SuperLearner: A theoretically grounded, cross-validated ensemble learning method that combines predictions from multiple algorithms to minimize predictive risk. Widely used in TMLE for estimating nuisance parameters. The original implementation is available as the R package SuperLearner. Recent machine learning platforms like H2O AutoML implement similar ensemble strategies, combining diverse learners in parallel and leveraging stacking and blending techniques, effectively functioning as a large-scale Super Learner.
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Amazon Rekognition

Amazon Rekognition is a cloud-based software as a service (SaaS) computer vision platform that was launched in 2016. It has been sold to, and used by, a number of United States government agencies, including U.S. Immigration and Customs Enforcement (ICE) and Orlando, Florida police, as well as private entities. == Capabilities == Rekognition provides a number of computer vision capabilities, which can be divided into two categories: Algorithms that are pre-trained on data collected by Amazon or its partners, and algorithms that a user can train on a custom dataset. As of July 2019, Rekognition provides the following computer vision capabilities. === Pre-trained algorithms === Celebrity recognition in images Facial attribute detection in images, including gender, age range, emotions (e.g. happy, calm, disgusted), whether the face has a beard or mustache, whether the face has eyeglasses or sunglasses, whether the eyes are open, whether the mouth is open, whether the person is smiling, and the location of several markers such as the pupils and jaw line. People Pathing enables tracking of people through a video. An advertised use-case of this capability is to track sports players for post-game analysis. Text detection and classification in images Unsafe visual content detection === Algorithms that a user can train on a custom dataset === SearchFaces enables users to import a database of images with pre-labeled faces, to train a machine learning model on this database, and to expose the model as a cloud service with an API. Then, the user can post new images to the API and receive information about the faces in the image. The API can be used to expose a number of capabilities, including identifying faces of known people, comparing faces, and finding similar faces in a database. Face-based user verification == History and use == === 2017 === In late 2017, the Washington County, Oregon Sheriff's Office began using Rekognition to identify suspects' faces. Rekognition was marketed as a general-purpose computer vision tool, and an engineer working for Washington County decided to use the tool for facial analysis of suspects. Rekognition was offered to the department for free, and Washington County became the first US law enforcement agency known to use Rekognition. In 2018, the agency logged over 1,000 facial searches. The county, according to the Washington Post, by 2019 was paying about $7 a month for all of its searches. The relationship was unknown to the public until May 2018. In 2018, Rekognition was also used to help identify celebrities during a royal wedding telecast. === 2018 === In April 2018, it was reported that FamilySearch was using Rekognition to enable their users to "see which of their ancestors they most resemble based on family photographs". In early 2018, the FBI also began using it as a pilot program for analyzing video surveillance. In May 2018, it was reported by the ACLU that Orlando, Florida was running a pilot using Rekognition for facial analysis in law enforcement, with that pilot ending in July 2019. After the report, on June 22, 2018, Gizmodo reported that Amazon workers had written a letter to CEO Jeff Bezos requesting he cease selling Rekognition to US law enforcement, particularly ICE and Homeland Security. A letter was also sent to Bezos by the ACLU. On June 26, 2018, it was reported that the Orlando police force had ceased using Rekognition after their trial contract expired, reserving the right to use it in the future. The Orlando Police Department said that they had "never gotten to the point to test images" due to old infrastructure and low bandwidth. In July 2018, the ACLU released a test showing that Rekognition had falsely matched 28 members of Congress with mugshot photos, particularly Congresspeople of color. 25 House members afterwards sent a letter to Bezos, expressing concern about Rekognition. Amazon responded saying the Rekognition test had generated 80 percent confidence, while it recommended law enforcement only use matches rated at 99 percent confidence. The Washington Post states that Oregon instead has officers pick a "best of five" result, instead of adhering to the recommendation. In September 2018, it was reported that Mapillary was using Rekognition to read the text on parking signs (e.g. no stopping, no parking, or specific parking hours) in cities. In October 2018, it was reported that Amazon had earlier that year pitched Rekognition to U.S. Immigration and Customs Enforcement agency. Amazon defended government use of Rekognition. On December 1, 2018, it was reported that 8 Democratic lawmakers had said in a letter that Amazon had "failed to provide sufficient answers" about Rekognition, writing that they had "serious concerns that this type of product has significant accuracy issues, places disproportionate burdens on communities of color, and could stifle Americans' willingness to exercise their First Amendment rights in public." === 2019 === In January 2019, MIT researchers published a peer-reviewed study asserting that Rekognition had more difficulty in identifying dark-skinned females than competitors such as IBM and Microsoft. In the study, Rekognition misidentified darker-skinned women as men 31% of the time, but made no mistakes for light-skinned men. Amazon called the report "misinterpreted results" of the research with an improper "default confidence threshold." In January 2019, Amazon's shareholders "urged Amazon to stop selling Rekognition software to law enforcement agencies." Amazon in response defended its use of Rekognition, but supported new federal oversight and guidelines to "make sure facial recognition technology cannot be used to discriminate." In February 2019, it was reported that Amazon was collaborating with the National Institute of Standards and Technology (NIST) on developing standardized tests to improve accuracy and remove bias with facial recognition. In March 2019, an open letter regarding Rekognition was sent by a group of prominent AI researchers to Amazon, criticizing its sale to law enforcement with around 50 signatures. In April 2019, Amazon was told by the Securities and Exchange Commission that they had to vote on two shareholder proposals seeking to limit Rekognition. Amazon argued that the proposals were an "insignificant public policy issue for the Company" not related to Amazon's ordinary business, but their appeal was denied. The vote was set for May. The first proposal was tabled by shareholders. On May 24, 2019, 2.4% of shareholders voted to stop selling Rekognition to government agencies, while a second proposal calling for a study into Rekognition and civil rights had 27.5% support. In August 2019, the ACLU again used Rekognition on members of government, with 26 of 120 lawmakers in California flagged as matches to mugshots. Amazon stated the ACLU was "misusing" the software in the tests, by not dismissing results that did not meet Amazon's recommended accuracy threshold of 99%. By August 2019, there had been protests against ICE's use of Rekognition to surveil immigrants. In March 2019, Amazon announced a Rekognition update that would improve emotional detection, and in August 2019, "fear" was added to emotions that Rekognition could detect. === 2020 === In June 2020, Amazon announced it was implementing a one-year moratorium on police use of Rekognition, in response to the George Floyd protests. === 2024 === The Department of Justice disclosed that the FBI is initiating the use of Amazon Rekognition. The DOJ's AI inventory revealed the FBI's "Project Tyr" aims to customize Rekognition to identify nudity, weapons, explosives, and other information from lawfully acquired media. === 2025 === In late 2025, the New York Times reported that scientist, Dr. Jürgen Matthäus, retired from as the head of research at the U.S. Holocaust Memorial Museum in Washington, D.C., used Amazon Rekognition to identify the shooter in the Holocaust photograph known as The Last Jew in Vinnitsa "with more than 99 percent certainty" — as Jakobus Onnen (1906–1943), a teacher from Tichelwarf near Weener in East Frisia who had been a member of the SS since 1934 and was later killed in action near Zhitomir in 1943. The photographer and victim remain unidentified. == Controversy regarding facial analysis == === Racial and gender bias === In 2018, MIT researchers Joy Buolamwini and Timnit Gebru published a study called Gender Shades. In this study, a set of images was collected, and faces in the images were labeled with face position, gender, and skin tone information. The images were run through SaaS facial recognition platforms from Face++, IBM, and Microsoft. In all three of these platforms, the classifiers performed best on male faces (with error rates on female faces being 8.1% to 20.6% higher than error rates on male faces), and they performed worst on dark female faces (with error rates ranging from 20.8% to 30.4%). The authors hypothesized that this discr
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Probit model

In statistics, a probit model is a type of regression where the dependent variable can take only two values, for example married or not married. The word is a portmanteau, coming from probability + unit. The purpose of the model is to estimate the probability that an observation with particular characteristics will fall into a specific one of the categories; moreover, classifying observations based on their predicted probabilities is a type of binary classification model. A probit model is a popular specification for a binary response model. As such it treats the same set of problems as does logistic regression using similar techniques. When viewed in the generalized linear model framework, the probit model employs a probit link function. It is most often estimated using the maximum likelihood procedure, such an estimation being called a probit regression. == Conceptual framework == Suppose a response variable Y is binary, that is it can have only two possible outcomes which we will denote as 1 and 0. For example, Y may represent presence/absence of a certain condition, success/failure of some device, answer yes/no on a survey, etc. We also have a vector of regressors X, which are assumed to influence the outcome Y. Specifically, we assume that the model takes the form P ( Y = 1 ∣ X ) = Φ ( X T β ) , {\displaystyle P(Y=1\mid X)=\Phi (X^{\operatorname {T} }\beta ),} where P is the probability and Φ {\displaystyle \Phi } is the cumulative distribution function (CDF) of the standard normal distribution. The parameters β are typically estimated by maximum likelihood. It is possible to motivate the probit model as a latent variable model. Suppose there exists an auxiliary random variable Y ∗ = X T β + ε , {\displaystyle Y^{\ast }=X^{T}\beta +\varepsilon ,} where ε ~ N(0, 1). Then Y can be viewed as an indicator for whether this latent variable is positive: Y = { 1 Y ∗ > 0 0 otherwise } = { 1 X T β + ε > 0 0 otherwise } {\displaystyle Y=\left.{\begin{cases}1&Y^{}>0\\0&{\text{otherwise}}\end{cases}}\right\}=\left.{\begin{cases}1&X^{\operatorname {T} }\beta +\varepsilon >0\\0&{\text{otherwise}}\end{cases}}\right\}} The use of the standard normal distribution causes no loss of generality compared with the use of a normal distribution with an arbitrary mean and standard deviation, because adding a fixed amount to the mean can be compensated by subtracting the same amount from the intercept, and multiplying the standard deviation by a fixed amount can be compensated by multiplying the weights by the same amount. To see that the two models are equivalent, note that P ( Y = 1 ∣ X ) = P ( Y ∗ > 0 ) = P ( X T β + ε > 0 ) = P ( ε > − X T β ) = P ( ε < X T β ) by symmetry of the normal distribution = Φ ( X T β ) {\displaystyle {\begin{aligned}P(Y=1\mid X)&=P(Y^{\ast }>0)\\&=P(X^{\operatorname {T} }\beta +\varepsilon >0)\\&=P(\varepsilon >-X^{\operatorname {T} }\beta )\\&=P(\varepsilon 0 {\displaystyle t,\lim _{n\rightarrow \infty }n_{t}/n=c_{t}>0} . Denote p ^ t = r t / n t {\displaystyle {\hat {p}}_{t}=r_{t}/n_{t}} σ ^ t 2 = 1 n t p ^ t ( 1 − p ^ t ) φ 2 ( Φ − 1 ( p ^ t ) ) {\displaystyle {\hat {\sigma }}_{t}^{2}={\frac {1}{n_{t}}}{\frac {{\hat {p}}_{t}(1-{\hat {p}}_{t})}{\varphi ^{2}{\big (}\Phi ^{-1}({\hat {p}}_{t}){\big )}}}} Then Berkson's minimum chi-square estimator is a generalized least squares estimator in a regression of Φ − 1 ( p ^ t ) {\displaystyle \Phi ^{-1}({\hat {p}}_{t})} on x ( t ) {\displaystyle x_{(t)}} with weights σ ^ t − 2 {\displaystyle {\hat {\sigma }}_{t}^{-2}} : β ^ = ( ∑ t = 1 T σ ^ t − 2 x ( t ) x ( t ) T ) − 1 ∑ t = 1 T σ ^ t − 2 x ( t ) Φ − 1 ( p ^ t ) {\displaystyle {\hat {\beta }}={\Bigg (}\sum _{t=1}^{T}{\hat {\sigma }}_{t}^{-2}x_{(t)}x_{(t)}^{\operatorname {T} }{\Bigg )}^{-1}\sum _{t=1}^{T}{\hat {\sigma }}_{t}^{-2}x_{(t)}\Phi ^{-1}({\hat {p}}_{t})} It can be shown that this estimator is consistent (as n→∞ and T fixed), asymptotically normal and efficient. Its advantage is the presence of a closed-form formula for the estimator. However, it is only meaningful to carry out this analysis when individual observations are not available, only their aggregated counts r t {\displaystyle r_{t}} , n t {\disp
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Fyre (software)

Fyre, formerly de Jong Explorer, is a cross-platform tool for producing artwork based on histograms of iterated chaotic functions. It implements the Peter de Jong map in a fixed function pipeline through either a GTK GUI frontend, or a command line facility for easier rendering of high-resolution, high quality images. The program was renamed from de Jong Explorer to Fyre simply because 'It wasn't taken yet' and so that in the future, it could support more functions than just the standard Peter de Jong map. Fyre features a sidebar on the left to which the user can input the required variables and on the right is displayed the result of the equation. == Extra features == Additional image manipulation tools such as Gaussian blurs and Gamma controls are included in the program. The advantage to using them directly within Fyre is that the image accuracy and quality do not decline. Fyre features animation capabilities so that a user can link together several maps and create uncompressed AVIs from them. However, the uncompressed animation files are very large and so should be compressed with a separate tool, such as mencoder. == Peter de Jong Map == For most values of a,b,c and d the point (x,y) moves chaotically. The resulting image is a map of the probability that the point lies within the area represented by each pixel. Therefore, the longer that the user lets Fyre render for, the larger the probability map becomes and the more accurate the resulting image.
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KXEN Inc.

KXEN was an American software company which existed from 1998 to 2013 when it was acquired by SAP AG. == History == KXEN was founded in June 1998 by Roger Haddad and Michel Bera. It was based in San Francisco, California with offices in Paris and London. On September 10, 2013, SAP AG announced plans to acquire KXEN. On October 1, 2013, a letter to KXEN customers announced the acquisition closed. KXEN primarily marketed predictive analytics software. == Predictive analytics == InfiniteInsight is a predictive modeling suite developed by KXEN that assists analytic professionals, and business executives to extract information from data. Among other functions, InfiniteInsight is used for variable importance, classification, regression, segmentation, time series, product recommendation, as described and expressed by the Java Data Mining interface, and for social network analysis. InfiniteInsight allows prediction of a behavior or a value, the forecast of a time series or the understanding of a group of individuals with similar behavior. Advanced functions include behavioral modeling, exporting the model code into different target environments or building predictive models on top of SAS or SPSS data files. Competitors are SAS Enterprise Miner, IBM SPSS Modeler, and Statistica. Open source predictive tools like the R package or Weka are also competitors, since they provide similar features free of charge.
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Kernel method

In machine learning, kernel machines are a class of algorithms for pattern analysis, whose best known member is the support-vector machine (SVM). These methods involve using linear classifiers to solve nonlinear problems. The general task of pattern analysis is to find and study general types of relations (for example clusters, rankings, principal components, correlations, classifications) in datasets. For many algorithms that solve these tasks, the data in raw representation have to be explicitly transformed into feature vector representations via a user-specified feature map: in contrast, kernel methods require only a user-specified kernel, i.e., a similarity function over all pairs of data points computed using inner products. The feature map in kernel machines is infinite dimensional but only requires a finite dimensional matrix from user-input according to the representer theorem. Kernel machines are slow to compute for datasets larger than a couple of thousand examples without parallel processing. Kernel methods owe their name to the use of kernel functions, which enable them to operate in a high-dimensional, implicit feature space without ever computing the coordinates of the data in that space, but rather by simply computing the inner products between the images of all pairs of data in the feature space. This operation is often computationally cheaper than the explicit computation of the coordinates. This approach is called the "kernel trick". Kernel functions have been introduced for sequence data, graphs, text, images, as well as vectors. Algorithms capable of operating with kernels include the kernel perceptron, support-vector machines (SVM), Gaussian processes, principal components analysis (PCA), canonical correlation analysis, ridge regression, spectral clustering, linear adaptive filters and many others. Most kernel algorithms are based on convex optimization or eigenproblems and are statistically well-founded. Typically, their statistical properties are analyzed using statistical learning theory (for example, using Rademacher complexity). == Motivation and informal explanation == Kernel methods can be thought of as instance-based learners: rather than learning some fixed set of parameters corresponding to the features of their inputs, they instead "remember" the i {\displaystyle i} -th training example ( x i , y i ) {\displaystyle (\mathbf {x} _{i},y_{i})} and learn for it a corresponding weight w i {\displaystyle w_{i}} . Prediction for unlabeled inputs, i.e., those not in the training set, are treated by the application of a similarity function k {\displaystyle k} , called a kernel, between the unlabeled input x ′ {\displaystyle \mathbf {x'} } and each of the training inputs x i {\displaystyle \mathbf {x} _{i}} . For instance, a kernelized binary classifier typically computes a weighted sum of similarities y ^ = sgn ⁡ ∑ i = 1 n w i y i k ( x i , x ′ ) , {\displaystyle {\hat {y}}=\operatorname {sgn} \sum _{i=1}^{n}w_{i}y_{i}k(\mathbf {x} _{i},\mathbf {x'} ),} where y ^ ∈ { − 1 , + 1 } {\displaystyle {\hat {y}}\in \{-1,+1\}} is the kernelized binary classifier's predicted label for the unlabeled input x ′ {\displaystyle \mathbf {x'} } whose hidden true label y {\displaystyle y} is of interest; k : X × X → R {\displaystyle k\colon {\mathcal {X}}\times {\mathcal {X}}\to \mathbb {R} } is the kernel function that measures similarity between any pair of inputs x , x ′ ∈ X {\displaystyle \mathbf {x} ,\mathbf {x'} \in {\mathcal {X}}} ; the sum ranges over the n labeled examples { ( x i , y i ) } i = 1 n {\displaystyle \{(\mathbf {x} _{i},y_{i})\}_{i=1}^{n}} in the classifier's training set, with y i ∈ { − 1 , + 1 } {\displaystyle y_{i}\in \{-1,+1\}} ; the w i ∈ R {\displaystyle w_{i}\in \mathbb {R} } are the weights for the training examples, as determined by the learning algorithm; the sign function sgn {\displaystyle \operatorname {sgn} } determines whether the predicted classification y ^ {\displaystyle {\hat {y}}} comes out positive or negative. Kernel classifiers were described as early as the 1960s, with the invention of the kernel perceptron. They rose to great prominence with the popularity of the support-vector machine (SVM) in the 1990s, when the SVM was found to be competitive with neural networks on tasks such as handwriting recognition. == Mathematics: the kernel trick == The kernel trick avoids the explicit mapping that is needed to get linear learning algorithms to learn a nonlinear function or decision boundary. For all x {\displaystyle \mathbf {x} } and x ′ {\displaystyle \mathbf {x'} } in the input space X {\displaystyle {\mathcal {X}}} , certain functions k ( x , x ′ ) {\displaystyle k(\mathbf {x} ,\mathbf {x'} )} can be expressed as an inner product in another space V {\displaystyle {\mathcal {V}}} . The function k : X × X → R {\displaystyle k\colon {\mathcal {X}}\times {\mathcal {X}}\to \mathbb {R} } is often referred to as a kernel or a kernel function. The word "kernel" is used in mathematics to denote a weighting function for a weighted sum or integral. Certain problems in machine learning have more structure than an arbitrary weighting function k {\displaystyle k} . The computation is made much simpler if the kernel can be written in the form of a "feature map" φ : X → V {\displaystyle \varphi \colon {\mathcal {X}}\to {\mathcal {V}}} which satisfies k ( x , x ′ ) = ⟨ φ ( x ) , φ ( x ′ ) ⟩ V . {\displaystyle k(\mathbf {x} ,\mathbf {x'} )=\langle \varphi (\mathbf {x} ),\varphi (\mathbf {x'} )\rangle _{\mathcal {V}}.} The key restriction is that ⟨ ⋅ , ⋅ ⟩ V {\displaystyle \langle \cdot ,\cdot \rangle _{\mathcal {V}}} must be a proper inner product. On the other hand, an explicit representation for φ {\displaystyle \varphi } is not necessary, as long as V {\displaystyle {\mathcal {V}}} is an inner product space. The alternative follows from Mercer's theorem: an implicitly defined function φ {\displaystyle \varphi } exists whenever the space X {\displaystyle {\mathcal {X}}} can be equipped with a suitable measure ensuring the function k {\displaystyle k} satisfies Mercer's condition. Mercer's theorem is similar to a generalization of the result from linear algebra that associates an inner product to any positive-definite matrix. In fact, Mercer's condition can be reduced to this simpler case. If we choose as our measure the counting measure μ ( T ) = | T | {\displaystyle \mu (T)=|T|} for all T ⊂ X {\displaystyle T\subset X} , which counts the number of points inside the set T {\displaystyle T} , then the integral in Mercer's theorem reduces to a summation ∑ i = 1 n ∑ j = 1 n k ( x i , x j ) c i c j ≥ 0. {\displaystyle \sum _{i=1}^{n}\sum _{j=1}^{n}k(\mathbf {x} _{i},\mathbf {x} _{j})c_{i}c_{j}\geq 0.} If this summation holds for all finite sequences of points ( x 1 , … , x n ) {\displaystyle (\mathbf {x} _{1},\dotsc ,\mathbf {x} _{n})} in X {\displaystyle {\mathcal {X}}} and all choices of n {\displaystyle n} real-valued coefficients ( c 1 , … , c n ) {\displaystyle (c_{1},\dots ,c_{n})} (cf. positive definite kernel), then the function k {\displaystyle k} satisfies Mercer's condition. Some algorithms that depend on arbitrary relationships in the native space X {\displaystyle {\mathcal {X}}} would, in fact, have a linear interpretation in a different setting: the range space of φ {\displaystyle \varphi } . The linear interpretation gives us insight about the algorithm. Furthermore, there is often no need to compute φ {\displaystyle \varphi } directly during computation, as is the case with support-vector machines. Some cite this running time shortcut as the primary benefit. Researchers also use it to justify the meanings and properties of existing algorithms. Theoretically, a Gram matrix K ∈ R n × n {\displaystyle \mathbf {K} \in \mathbb {R} ^{n\times n}} with respect to { x 1 , … , x n } {\displaystyle \{\mathbf {x} _{1},\dotsc ,\mathbf {x} _{n}\}} (sometimes also called a "kernel matrix"), where K i j = k ( x i , x j ) {\displaystyle K_{ij}=k(\mathbf {x} _{i},\mathbf {x} _{j})} , must be positive semi-definite (PSD). Empirically, for machine learning heuristics, choices of a function k {\displaystyle k} that do not satisfy Mercer's condition may still perform reasonably if k {\displaystyle k} at least approximates the intuitive idea of similarity. Regardless of whether k {\displaystyle k} is a Mercer kernel, k {\displaystyle k} may still be referred to as a "kernel". If the kernel function k {\displaystyle k} is also a covariance function as used in Gaussian processes, then the Gram matrix K {\displaystyle \mathbf {K} } can also be called a covariance matrix. == Applications == Application areas of kernel methods are diverse and include geostatistics, kriging, inverse distance weighting, 3D reconstruction, bioinformatics, cheminformatics, information extraction and handwriting recognition. == Popular kernels == Fisher kernel Graph kernels Kernel smoother Polynomial kernel Radial basis function kern
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Mean squared error

In statistics, the mean squared error (MSE) or mean squared deviation (MSD) of an estimator (of a procedure for estimating an unobserved quantity) measures the average of the squares of the errors—that is, the average squared difference between the estimated values and the true value. MSE is a risk function, corresponding to the expected value of the squared error loss. The fact that MSE is almost always strictly positive (and not zero) is because of randomness or because the estimator does not account for information that could produce a more accurate estimate. In machine learning, specifically empirical risk minimization, MSE may refer to the empirical risk (the average loss on an observed data set), as an estimate of the true MSE (the true risk: the average loss on the actual population distribution). The MSE is a measure of the quality of an estimator. As it is derived from the square of Euclidean distance, it is always a positive value that decreases as the error approaches zero. The MSE is the second moment (about the origin) of the error, and thus incorporates both the variance of the estimator (how widely spread the estimates are from one data sample to another) and its bias (how far off the average estimated value is from the true value). For an unbiased estimator, the MSE is the variance of the estimator. Like the variance, MSE has the same units of measurement as the square of the quantity being estimated. In an analogy to standard deviation, taking the square root of MSE yields the root-mean-square error or root-mean-square deviation (RMSE or RMSD), which has the same units as the quantity being estimated; for an unbiased estimator, the RMSE is the square root of the variance, known as the standard error. == Definition and basic properties == The MSE either assesses the quality of a predictor (i.e., a function mapping arbitrary inputs to a sample of values of some random variable), or of an estimator (i.e., a mathematical function mapping a sample of data to an estimate of a parameter of the population from which the data is sampled). In the context of prediction, understanding the prediction interval can also be useful as it provides a range within which a future observation will fall, with a certain probability. The definition of an MSE differs according to whether one is describing a predictor or an estimator. === Predictor === If a vector of n {\displaystyle n} predictions is generated from a sample of n {\displaystyle n} data points on all variables, and Y {\displaystyle Y} is the vector of observed values of the variable being predicted, with Y ^ {\displaystyle {\hat {Y}}} being the predicted values (e.g. as from a least-squares fit), then the within-sample MSE of the predictor is computed as MSE = 1 n ∑ i = 1 n ( Y i − Y i ^ ) 2 {\displaystyle \operatorname {MSE} ={\frac {1}{n}}\sum _{i=1}^{n}\left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} In other words, the MSE is the mean ( 1 n ∑ i = 1 n ) {\textstyle \left({\frac {1}{n}}\sum _{i=1}^{n}\right)} of the squares of the errors ( Y i − Y i ^ ) 2 {\textstyle \left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} . This is an easily computable quantity for a particular sample (and hence is sample-dependent). In matrix notation, MSE = 1 n ∑ i = 1 n ( e i ) 2 = 1 n e T e {\displaystyle \operatorname {MSE} ={\frac {1}{n}}\sum _{i=1}^{n}(e_{i})^{2}={\frac {1}{n}}\mathbf {e} ^{\mathsf {T}}\mathbf {e} } where e i {\displaystyle e_{i}} is Y i − Y i ^ {\displaystyle Y_{i}-{\hat {Y_{i}}}} and e {\displaystyle \mathbf {e} } is a n × 1 {\displaystyle n\times 1} column vector. The MSE can also be computed on q data points that were not used in estimating the model, either because they were held back for this purpose, or because these data have been newly obtained. Within this process, known as cross-validation, the MSE is often called the test MSE, and is computed as MSE = 1 q ∑ i = n + 1 n + q ( Y i − Y i ^ ) 2 {\displaystyle \operatorname {MSE} ={\frac {1}{q}}\sum _{i=n+1}^{n+q}\left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} === Estimator === The MSE of an estimator θ ^ {\displaystyle {\hat {\theta }}} with respect to an unknown parameter θ {\displaystyle \theta } is defined as MSE ⁡ ( θ ^ ) = E θ ⁡ [ ( θ ^ − θ ) 2 ] . {\displaystyle \operatorname {MSE} ({\hat {\theta }})=\operatorname {E} _{\theta }\left[({\hat {\theta }}-\theta )^{2}\right].} This definition depends on the unknown parameter, therefore the MSE is a priori property of an estimator. The MSE could be a function of unknown parameters, in which case any estimator of the MSE based on estimates of these parameters would be a function of the data (and thus a random variable). If the estimator θ ^ {\displaystyle {\hat {\theta }}} is derived as a sample statistic and is used to estimate some population parameter, then the expectation is with respect to the sampling distribution of the sample statistic. The MSE can be written as the sum of the variance of the estimator and the squared bias of the estimator, providing a useful way to calculate the MSE and implying that in the case of unbiased estimators, the MSE and variance are equivalent. MSE ⁡ ( θ ^ ) = Var θ ⁡ ( θ ^ ) + Bias ⁡ ( θ ^ , θ ) 2 . {\displaystyle \operatorname {MSE} ({\hat {\theta }})=\operatorname {Var} _{\theta }({\hat {\theta }})+\operatorname {Bias} ({\hat {\theta }},\theta )^{2}.} ==== Proof of variance and bias relationship ==== MSE ⁡ ( θ ^ ) = E θ ⁡ [ ( θ ^ − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] + E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 + 2 ( θ ^ − E θ ⁡ [ θ ^ ] ) ( E θ ⁡ [ θ ^ ] − θ ) + ( E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + E θ ⁡ [ 2 ( θ ^ − E θ ⁡ [ θ ^ ] ) ( E θ ⁡ [ θ ^ ] − θ ) ] + E θ ⁡ [ ( E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + 2 ( E θ ⁡ [ θ ^ ] − θ ) E θ ⁡ [ θ ^ − E θ ⁡ [ θ ^ ] ] + ( E θ ⁡ [ θ ^ ] − θ ) 2 E θ ⁡ [ θ ^ ] − θ = constant = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + 2 ( E θ ⁡ [ θ ^ ] − θ ) ( E θ ⁡ [ θ ^ ] − E θ ⁡ [ θ ^ ] ) + ( E θ ⁡ [ θ ^ ] − θ ) 2 E θ ⁡ [ θ ^ ] = constant = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + ( E θ ⁡ [ θ ^ ] − θ ) 2 = Var θ ⁡ ( θ ^ ) + Bias θ ⁡ ( θ ^ , θ ) 2 {\displaystyle {\begin{aligned}\operatorname {MSE} ({\hat {\theta }})&=\operatorname {E} _{\theta }\left[({\hat {\theta }}-\theta )^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]+\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}+2\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+\operatorname {E} _{\theta }\left[2\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\right]+\operatorname {E} _{\theta }\left[\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+2\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\operatorname {E} _{\theta }\left[{\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right]+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}&&\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta ={\text{constant}}\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+2\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}&&\operatorname {E} _{\theta }[{\hat {\theta }}]={\text{constant}}\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\\&=\operatorname {Var} _{\theta }({\hat {\theta }})+\operatorname {Bias} _{\theta }({\hat {\theta }},\theta )^{2}\end{aligned}}} An even shorter proof can be achieved using the well-known formula that for a random variable X {\textstyle X} , E ( X 2 ) = Var ⁡ ( X ) + ( E ( X ) ) 2 {\textstyle \mathbb {E} (X^{2})=\operatorname {Var} (X)+(\mathbb {E} (X))^{2}} . By substituting X {\textstyle X} with, θ ^ − θ {\textstyle {\hat {\theta }}-\theta } , we have MSE ⁡ ( θ ^ ) = E [ ( θ ^ − θ ) 2 ] = Var ⁡ ( θ ^ − θ ) + ( E [ θ ^ − θ ] ) 2 = Var ⁡ ( θ ^ ) + Bias 2 ⁡ ( θ ^ , θ ) {\displaystyle {\begin{aligned}\operatorname {MSE} ({\hat {\theta }})&=\mathbb {E} [({\hat {\theta }}-\theta )^{2}]\\&=\operator
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Language resource

In linguistics and language technology, a language resource is a "[composition] of linguistic material used in the construction, improvement and/or evaluation of language processing applications, (...) in language and language-mediated research studies and applications." According to Bird & Simons (2003), this includes data, i.e. "any information that documents or describes a language, such as a published monograph, a computer data file, or even a shoebox full of handwritten index cards. The information could range in content from unanalyzed sound recordings to fully transcribed and annotated texts to a complete descriptive grammar", tools, i.e., "computational resources that facilitate creating, viewing, querying, or otherwise using language data", and advice, i.e., "any information about what data sources are reliable, what tools are appropriate in a given situation, what practices to follow when creating new data". The latter aspect is usually referred to as "best practices" or "(community) standards". In a narrower sense, language resource is specifically applied to resources that are available in digital form, and then, "encompassing (a) data sets (textual, multimodal/multimedia and lexical data, grammars, language models, etc.) in machine readable form, and (b) tools/technologies/services used for their processing and management". == Typology == As of May 2020, no widely used standard typology of language resources has been established (current proposals include the LREMap, METASHARE, and, for data, the LLOD classification). Important classes of language resources include data lexical resources, e.g., machine-readable dictionaries, linguistic corpora, i.e., digital collections of natural language data, linguistic data bases such as the Cross-Linguistic Linked Data collection, tools linguistic annotations and tools for creating such annotations in a manual or semiautomated fashion (e.g., tools for annotating interlinear glossed text such as Toolbox and FLEx, or other language documentation tools), applications for search and retrieval over such data (corpus management systems), for automated annotation (part-of-speech tagging, syntactic parsing, semantic parsing, etc.), metadata and vocabularies vocabularies, repositories of linguistic terminology and language metadata, e.g., MetaShare (for language resource metadata), the ISO 12620 data category registry (for linguistic features, data structures and annotations within a language resource), or the Glottolog database (identifiers for language varieties and bibliographical database). == Language resource publication, dissemination and creation == A major concern of the language resource community has been to develop infrastructures and platforms to present, discuss and disseminate language resources. Selected contributions in this regard include: a series of International Conferences on Language Resources and Evaluation (LREC), the European Language Resources Association (ELRA, EU-based), and the Linguistic Data Consortium (LDC, US-based), which represent commercial hosting and dissemination platforms for language resources, the Open Languages Archives Community (OLAC), which provides and aggregates language resource metadata, the Language Resources and Evaluation Journal (LREJ), the European Language Grid is a European platform for language technologies (eg services), data and resources. As for the development of standards and best practices for language resources, these are subject of several community groups and standardization efforts, including ISO Technical Committee 37: Terminology and other language and content resources (ISO/TC 37), developing standards for all aspects of language resources, W3C Community Group Best Practices for Multilingual Linked Open Data (BPMLOD), working on best practice recommendations for publishing language resources as Linked Data or in RDF, W3C Community Group Linked Data for Language Technology (LD4LT), working on linguistic annotations on the web and language resource metadata, W3C Community Group Ontology-Lexica (OntoLex), working on lexical resources, the Open Linguistics working group of the Open Knowledge Foundation, working on conventions for publishing and linking open language resources, developing the Linguistic Linked Open Data cloud, the Text Encoding Initiative (TEI), working on XML-based specifications for language resources and digitally edited text.
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Chromosome (evolutionary algorithm)

A chromosome or genotype in evolutionary algorithms (EA) is a set of parameters which define a proposed solution of the problem that the evolutionary algorithm is trying to solve. The set of all solutions, also called individuals according to the biological model, is known as the population. The genome of an individual consists of one, more rarely of several, chromosomes and corresponds to the genetic representation of the task to be solved. A chromosome is composed of a set of genes, where a gene consists of one or more semantically connected parameters, which are often also called decision variables. They determine one or more phenotypic characteristics of the individual or at least have an influence on them. In the basic form of genetic algorithms, the chromosome is represented as a binary string, while in later variants and in EAs in general, a wide variety of other data structures are used. == Chromosome design == When creating the genetic representation of a task, it is determined which decision variables and other degrees of freedom of the task should be improved by the EA and possible additional heuristics and how the genotype-phenotype mapping should look like. The design of a chromosome translates these considerations into concrete data structures for which an EA then has to be selected, configured, extended, or, in the worst case, created. Finding a suitable representation of the problem domain for a chromosome is an important consideration, as a good representation will make the search easier by limiting the search space; similarly, a poorer representation will allow a larger search space. In this context, suitable mutation and crossover operators must also be found or newly defined to fit the chosen chromosome design. An important requirement for these operators is that they not only allow all points in the search space to be reached in principle, but also make this as easy as possible. The following requirements must be met by a well-suited chromosome: It must allow the accessibility of all admissible points in the search space. Design of the chromosome in such a way that it covers only the search space and no additional areas. so that there is no redundancy or only as little redundancy as possible. Observance of strong causality: small changes in the chromosome should only lead to small changes in the phenotype. This is also called locality of the relationship between search and problem space. Designing the chromosome in such a way that it excludes prohibited regions in the search space completely or as much as possible. While the first requirement is indispensable, depending on the application and the EA used, one usually only has to be satisfied with fulfilling the remaining requirements as far as possible. The evolutionary search is supported and possibly considerably accelerated by a fulfillment as complete as possible. == Examples of chromosomes == === Chromosomes for binary codings === In their classical form, GAs use bit strings and map the decision variables to be optimized onto them. An example for one Boolean and three integer decision variables with the value ranges 0 ≤ D 1 ≤ 60 {\displaystyle 0\leq D_{1}\leq 60} , 28 ≤ D 2 ≤ 30 {\displaystyle 28\leq D_{2}\leq 30} and − 12 ≤ D 3 ≤ 14 {\displaystyle -12\leq D_{3}\leq 14} may illustrate this: Note that the negative number here is given in two's complement. This straight forward representation uses five bits to represent the three values of D 2 {\displaystyle D_{2}} , although two bits would suffice. This is a significant redundancy. An improved alternative, where 28 is to be added for the genotype-phenotype mapping, could look like this: with D 2 = 28 + D 2 ′ = 29 {\displaystyle D_{2}=28+D'_{2}=29} . === Chromosomes with real-valued or integer genes === For the processing of tasks with real-valued or mixed-integer decision variables, EAs such as the evolution strategy or the real-coded GAs are suited. In the case of mixed-integer values, rounding is often used, but this represents some violation of the redundancy requirement. If the necessary precisions of the real values can be reasonably narrowed down, this violation can be remedied by using integer-coded GAs. For this purpose, the valid digits of real values are mapped to integers by multiplication with a suitable factor. For example, 12.380 becomes the integer 12380 by multiplying by 1000. This must of course be taken into account in genotype-phenotype mapping for evaluation and result presentation. A common form is a chromosome consisting of a list or an array of integer or real values. === Chromosomes for permutations === Combinatorial problems are mainly concerned with finding an optimal sequence of a set of elementary items. As an example, consider the problem of the traveling salesman who wants to visit a given number of cities exactly once on the shortest possible tour. The simplest and most obvious mapping onto a chromosome is to number the cities consecutively, to interpret a resulting sequence as permutation and to store it directly in a chromosome, where one gene corresponds to the ordinal number of a city. Then, however, the variation operators may only change the gene order and not remove or duplicate any genes. The chromosome thus contains the path of a possible tour to the cities. As an example the sequence 3 , 5 , 7 , 1 , 4 , 2 , 9 , 6 , 8 {\displaystyle 3,5,7,1,4,2,9,6,8} of nine cities may serve, to which the following chromosome corresponds: In addition to this encoding frequently called path representation, there are several other ways of representing a permutation, for example the ordinal representation or the matrix representation. === Chromosomes for co-evolution === When a genetic representation contains, in addition to the decision variables, additional information that influences evolution and/or the mapping of the genotype to the phenotype and is itself subject to evolution, this is referred to as co-evolution. A typical example is the evolution strategy (ES), which includes one or more mutation step sizes as strategy parameters in each chromosome. Another example is an additional gene to control a selection heuristic for resource allocation in a scheduling tasks. This approach is based on the assumption that good solutions are based on an appropriate selection of strategy parameters or on control gene(s) that influences genotype-phenotype mapping. The success of the ES gives evidence to this assumption. === Chromosomes for complex representations === The chromosomes presented above are well suited for processing tasks of continuous, mixed-integer, pure-integer or combinatorial optimization. For a combination of these optimization areas, on the other hand, it becomes increasingly difficult to map them to simple strings of values, depending on the task. The following extension of the gene concept is proposed by the EA GLEAM (General Learning Evolutionary Algorithm and Method) for this purpose: A gene is considered to be the description of an element or elementary trait of the phenotype, which may have multiple parameters. For this purpose, gene types are defined that contain as many parameters of the appropriate data type as are required to describe the particular element of the phenotype. A chromosome now consists of genes as data objects of the gene types, whereby, depending on the application, each gene type occurs exactly once as a gene or can be contained in the chromosome any number of times. The latter leads to chromosomes of dynamic length, as they are required for some problems. The gene type definitions also contain information on the permissible value ranges of the gene parameters, which are observed during chromosome generation and by corresponding mutations, so they cannot lead to lethal mutations. For tasks with a combinatorial part, there are suitable genetic operators that can move or reposition genes as a whole, i.e. with their parameters. A scheduling task is used as an illustration, in which workflows are to be scheduled that require different numbers of heterogeneous resources. A workflow specifies which work steps can be processed in parallel and which have to be executed one after the other. In this context, heterogeneous resources mean different processing times at different costs in addition to different processing capabilities. Each scheduling operation therefore requires one or more parameters that determine the resource selection, where the value ranges of the parameters depend on the number of alternative resources available for each work step. A suitable chromosome provides one gene type per work step and in this case one corresponding gene, which has one parameter for each required resource. The order of genes determines the order of scheduling operations and, therefore, the precedence in case of allocation conflicts. The exemplary gene type definition of work step 15 with two resources, for which there are four and seven alternatives respectively
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Multidimensional analysis

In statistics, econometrics and related fields, multidimensional analysis (MDA) is a data analysis process that groups data into two categories: data dimensions and measurements. For example, a data set consisting of the number of wins for a single football team at each of several years is a single-dimensional (in this case, longitudinal) data set. A data set consisting of the number of wins for several football teams in a single year is also a single-dimensional (in this case, cross-sectional) data set. A data set consisting of the number of wins for several football teams over several years is a two-dimensional data set. == Higher dimensions == In many disciplines, two-dimensional data sets are also called panel data. While, strictly speaking, two- and higher-dimensional data sets are "multi-dimensional", the term "multidimensional" tends to be applied only to data sets with three or more dimensions. For example, some forecast data sets provide forecasts for multiple target periods, conducted by multiple forecasters, and made at multiple horizons. The three dimensions provide more information than can be gleaned from two-dimensional panel data sets. == Software == Computer software for MDA include Online analytical processing (OLAP) for data in relational databases, pivot tables for data in spreadsheets, and Array DBMSs for general multi-dimensional data (such as raster data) in science, engineering, and business.
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Spatial Analysis of Principal Components

Spatial Principal Component Analysis (sPCA) is a multivariate statistical technique that complements the traditional Principal Component Analysis (PCA) by incorporating spatial information into the analysis of genetic variation. While traditional PCA can be used to find spatial patterns, it focuses on reducing data dimensionality by identifying uncorrelated principal components that capture maximum variance, thus often lacking power to identify non-trivial spatial genetic patterns. By accounting for spatial autocorrelation, sPCA is able to uncover spatial patterns in the data and find the spatial structure of datasets where observations are either geographically or topologically linked. This statistical power improvement allows the investigation of cryptic spatial patterns of genetic variability otherwise overlooked. sPCA has been applied in various fields, including geography, ecology and genetics. == History == sPCA was introduced in 2008 by Thibaut Jombart, Sébastien Devillard, Anne-Béatrice Dufour, and D. Pontier as a spatially explicit method to investigate the spatial pattern of genetic variation among individuals or populations. In 2017, Valeria Montano and Thibaut Jombart published an alternative non-parametric test to evaluate the significance of global and local spatial genetic patterns with improved statistical power. == Details == sPCA modifies the PCA framework by integrating spatial weights, typically in the form of connectivity matrices or spatial adjacency graphs. It identifies principal components (PCs) that maximize both genentic variance and spatial autocorreation, as measured by Moran's I. These weights represent relationships between observations based on geographic distance or other spatial criteria. The method decomposes variance into two components: Global structures, correspond to positive autocorrelation, that is, reflect broad-scale spatial patterns where similar values cluster over large regions. Local structures, correspond to negative autocorrelation, that is, capture fine-scale spatial variations or localized patterns. The core of sPCA relies on the eigenanalysis of a spatially weighted covariance or correlation matrix. The spatial weight matrix can be constructed using techniques such as Delaunay triangulation, nearest-neighbor graphs, or distance-based criteria. Applications of sPCA should be used only as an explorative tool. == Applications == sPCA has been widely used in many fields, including: Ecology: To find spatial patterns in species distributions and environmental gradients. Genetics: Population structure and gene flow analysis while allowing for spatial autocorrelation considerations. Biogeography: To identify historical dispersal routes, and barriers to gene flow, providing insights into species distribution patterns and evolutionary history. == Software/Source Code == sPCA implementations are available in R in adegenet and ntbox . These tools facilitate the application of sPCA by providing functions for constructing spatial weight matrices, performing eigenanalysis, and obtaining spatial principal components in an easy-to-read form.
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System appreciation

System appreciation is an activity often included in the maintenance phase of software engineering projects. Key deliverables from this phase include documentation that describes what the system does in terms of its functional features, and how it achieves those features in terms of its architecture and design. Software architecture recovery is often the first step within System appreciation.
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Prescription monitoring program

In the United States, prescription monitoring programs (PMPs) or prescription drug monitoring programs (PDMPs) are state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, depending on state requirements, other potentially abusable prescription drugs. PMPs are meant to help prevent adverse drug-related events such as opioid overdoses, drug diversion, and substance abuse by decreasing the amount and/or frequency of opioid prescribing, and by identifying those patients who are obtaining prescriptions from multiple providers (i.e., "doctor shopping") or those physicians overprescribing opioids. Most US health care workers support the idea of PMPs, which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments. The database, whose use is required by State law, typically requires prescribers and pharmacies dispensing controlled substances to register with their respective state PMPs and (for pharmacies and providers who dispense from their offices) to report the dispensation of such prescriptions to an electronic online database. The majority of PMPs are authorized to notify law enforcement agencies or licensing boards or physicians when a prescriber, or patients receiving prescriptions, exceed thresholds established by the state or prescription recipient exceeds thresholds established by the State. All states have implemented PDMPs, although evidence for the effectiveness of these programs is mixed. While prescription of opioids has decreased with PMP use, overdose deaths in many states have actually increased, with those states sharing data with neighboring jurisdictions or requiring reporting of more drugs experiencing highest increases in deaths. This may be because those declined opioid prescriptions turn to street drugs, whose potency and contaminants carry greater overdose risk. == History == Prescription drug monitoring programs, or PDMPs, are an example of one initiative proposed to alleviate effects of the opioid crisis. The programs are designed to restrict prescription drug abuse by limiting a patient's ability to obtain similar prescriptions from multiple providers (i.e. “doctor shopping”) and reducing diversion of controlled substances. This is meant to reduce risk of fatal overdose caused by high doses of opioids or interactions between opioids and benzodiazepenes, and to enable better decision making on the part of healthcare providers who may be unaware of a patient's prescription drug use, history or other prescriptions. PDMPs have been implemented in state legislations since 1939 in California, a time before electronic medical records, though implementation rose alongside increased awareness of overprescribing of opioids and overdose. A later New York state program was struck down by the U.S. Supreme Court in Whalen v. Roe. But, by 2019, 49 states, the District of Columbia, and Guam had enacted PDMP legislation. In 2021 Missouri, the last State to not use a PMP, adopted legislation to create one. PMPs are constantly being updated to increase speed of data collection, sharing of data across States, and ease of interpretation. This is being done by integrating PDMP reports with other health information technologies such as health information exchanges (HIE), electronic health record (EHR) systems, and/ or pharmacy dispensing software systems. One program that has been implemented in nine states is called the PDMP Electronic Health Records Integration and Interoperability Expansion, also known as PEHRIIE. Another software, marketed by Bamboo Health and integrated with PMPs in 43 states, uses an algorithm to track factors thought to increase risk of diversion, abuse or overdose, and assigns patients a three digit score based on presumed indicators of risk. While some studies have suggested that PDMP-HIT integration and sharing of interstate data brings benefits such as reduced opioid-related inpatient morbidity, others have found no or negative impact on mortality compared to states without PMP data sharing. Patient and media reports suggest need for testing and evaluation of algorithmic software used to score risk, with some patients reporting denial of prescriptions without c explanation or clarity of data. == Goals == Most health care workers support PMPs which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments, as well as law-enforcement agencies. The collaboration supports the legitimate medical use of controlled substances while limiting their abuse and diversion. Pharmacies dispensing controlled substances and prescribers typically must register with their respective state PMPs and (for pharmacies and providers who dispense controlled substances from their offices) report the dispensation to an electronic online database. Some pharmacy software can submit these reports automatically to multiple states. == Usage == === List of programs by state === === Software systems === NarxCare is a prescription drug monitoring program (PDMP) run by Bamboo Health. Bamboo Health was formerly known as Appriss. It is widely used across the United States by pharmacies including Rite Aid as well as those at Walmart and Sam’s Club. The NarxCare software allows doctors to view data about a patient, combining data from the prescription registries of various U.S. states to make the registries interoperable nationally. It also uses machine learning to generate an "Overdose Risk Score" that potentially includes EMS and criminal justice data; these scores have been criticized by researchers and patient advocates for the lack of transparency in the process as well as the potential for disparate treatment of women and minority groups. Advertised as an "analytics tool and care management platform", the NarxCare software allows doctors to view data about a patient including how many pharmacies they have visited and the combinations of medication they are prescribed. It combines data from the prescription registries of various U.S. states, making the registries interoperable nationally. It additionally uses machine learning to generate various three-digit "risk scores" and an overall "Overdose Risk Score", collectively referred to as Narx Scores, in a process that potentially includes EMS and criminal justice data as well as court records. == Controversy == Many doctors and researchers support the idea of PDMPs as a tool in combatting the opioid epidemic. Opioid prescribing, opioid diversion and supply, opioid misuse, and opioid-related morbidity and mortality are common elements in data entered into PDMPs. Prescription Monitoring Programs are purported to offer economic benefits for the states who implement them by decreasing overall health care costs, lost productivity, and investigation times. However, there are many studies that conclude the impact of PDMPs is unclear. While use of PMPs has been accompanied by decrease in opioid prescribing, few analyses consider corresponding use of street opioids, extramedical use, or diversion, which might provide a more holistic method for evaluation of PMP intent and efficacy. Evidence for PDMP impact on fatal overdoses is decidedly mixed, with multiple studies finding increased overdose rates in some states, decreases in others, or no clear impact. Interestingly, an increase in heroin overdoses after PDMP implementation has been commonly reported, presumably as denial of prescription opioids sends patients in search of street drugs. Narx Scores have been criticized by researchers and patient advocates for the lack of transparency in the generation process as well as the potential for disparate treatment of women and minority groups. Writing in Duke Law Journal, Jennifer Oliva stated that "black-box algorithms" are used to generate the scores.
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Mean squared prediction error

In statistics the mean squared prediction error (MSPE), also known as mean squared error of the predictions, of a smoothing, curve fitting, or regression procedure is the expected value of the squared prediction errors (PE), the square difference between the fitted values implied by the predictive function g ^ {\displaystyle {\widehat {g}}} and the values of the (unobservable) true value g. It is an inverse measure of the explanatory power of g ^ , {\displaystyle {\widehat {g}},} and can be used in the process of cross-validation of an estimated model. Knowledge of g would be required in order to calculate the MSPE exactly; in practice, MSPE is estimated. == Formulation == If the smoothing or fitting procedure has projection matrix (i.e., hat matrix) L, which maps the observed values vector y {\displaystyle y} to predicted values vector y ^ = L y , {\displaystyle {\hat {y}}=Ly,} then PE and MSPE are formulated as: P E i = g ( x i ) − g ^ ( x i ) , {\displaystyle \operatorname {PE_{i}} =g(x_{i})-{\widehat {g}}(x_{i}),} MSPE = E ⁡ [ PE i 2 ] = ∑ i = 1 n PE i 2 ⁡ / n . {\displaystyle \operatorname {MSPE} =\operatorname {E} \left[\operatorname {PE} _{i}^{2}\right]=\sum _{i=1}^{n}\operatorname {PE} _{i}^{2}/n.} The MSPE can be decomposed into two terms: the squared bias (mean error) of the fitted values and the variance of the fitted values: MSPE = ME 2 + VAR , {\displaystyle \operatorname {MSPE} =\operatorname {ME} ^{2}+\operatorname {VAR} ,} ME = E ⁡ [ g ^ ( x i ) − g ( x i ) ] {\displaystyle \operatorname {ME} =\operatorname {E} \left[{\widehat {g}}(x_{i})-g(x_{i})\right]} VAR = E ⁡ [ ( g ^ ( x i ) − E ⁡ [ g ( x i ) ] ) 2 ] . {\displaystyle \operatorname {VAR} =\operatorname {E} \left[\left({\widehat {g}}(x_{i})-\operatorname {E} \left[{g}(x_{i})\right]\right)^{2}\right].} The quantity SSPE=nMSPE is called sum squared prediction error. The root mean squared prediction error is the square root of MSPE: RMSPE=√MSPE. == Computation of MSPE over out-of-sample data == The mean squared prediction error can be computed exactly in two contexts. First, with a data sample of length n, the data analyst may run the regression over only q of the data points (with q < n), holding back the other n – q data points with the specific purpose of using them to compute the estimated model’s MSPE out of sample (i.e., not using data that were used in the model estimation process). Since the regression process is tailored to the q in-sample points, normally the in-sample MSPE will be smaller than the out-of-sample one computed over the n – q held-back points. If the increase in the MSPE out of sample compared to in sample is relatively slight, that results in the model being viewed favorably. And if two models are to be compared, the one with the lower MSPE over the n – q out-of-sample data points is viewed more favorably, regardless of the models’ relative in-sample performances. The out-of-sample MSPE in this context is exact for the out-of-sample data points that it was computed over, but is merely an estimate of the model’s MSPE for the mostly unobserved population from which the data were drawn. Second, as time goes on more data may become available to the data analyst, and then the MSPE can be computed over these new data. == Estimation of MSPE over the population == When the model has been estimated over all available data with none held back, the MSPE of the model over the entire population of mostly unobserved data can be estimated as follows. For the model y i = g ( x i ) + σ ε i {\displaystyle y_{i}=g(x_{i})+\sigma \varepsilon _{i}} where ε i ∼ N ( 0 , 1 ) {\displaystyle \varepsilon _{i}\sim {\mathcal {N}}(0,1)} , one may write n ⋅ MSPE ⁡ ( L ) = g T ( I − L ) T ( I − L ) g + σ 2 tr ⁡ [ L T L ] . {\displaystyle n\cdot \operatorname {MSPE} (L)=g^{\text{T}}(I-L)^{\text{T}}(I-L)g+\sigma ^{2}\operatorname {tr} \left[L^{\text{T}}L\right].} Using in-sample data values, the first term on the right side is equivalent to ∑ i = 1 n ( E ⁡ [ g ( x i ) − g ^ ( x i ) ] ) 2 = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 tr ⁡ [ ( I − L ) T ( I − L ) ] . {\displaystyle \sum _{i=1}^{n}\left(\operatorname {E} \left[g(x_{i})-{\widehat {g}}(x_{i})\right]\right)^{2}=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\operatorname {tr} \left[\left(I-L\right)^{T}\left(I-L\right)\right].} Thus, n ⋅ MSPE ⁡ ( L ) = E ⁡ [ ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 ] − σ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {MSPE} (L)=\operatorname {E} \left[\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}\right]-\sigma ^{2}\left(n-\operatorname {tr} \left[L\right]\right).} If σ 2 {\displaystyle \sigma ^{2}} is known or well-estimated by σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} , it becomes possible to estimate MSPE by n ⋅ M S P E ^ ⁡ ( L ) = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 − σ ^ 2 ( n − tr ⁡ [ L ] ) . {\displaystyle n\cdot \operatorname {\widehat {MSPE}} (L)=\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}-{\widehat {\sigma }}^{2}\left(n-\operatorname {tr} \left[L\right]\right).} Colin Mallows advocated this method in the construction of his model selection statistic Cp, which is a normalized version of the estimated MSPE: C p = ∑ i = 1 n ( y i − g ^ ( x i ) ) 2 σ ^ 2 − n + 2 p . {\displaystyle C_{p}={\frac {\sum _{i=1}^{n}\left(y_{i}-{\widehat {g}}(x_{i})\right)^{2}}{{\widehat {\sigma }}^{2}}}-n+2p.} where p the number of estimated parameters p and σ ^ 2 {\displaystyle {\widehat {\sigma }}^{2}} is computed from the version of the model that includes all possible regressors. That concludes this proof.
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