Indic Computing means "computing in Indic", i.e., Indian Scripts and Languages. It involves developing software in Indic Scripts/languages, Input methods, Localization of computer applications, web development, Database Management, Spell checkers, Speech to Text and Text to Speech applications and OCR in Indian languages. Unicode standard version 15.0 specifies codes for 9 Indic scripts in Chapter 12 titled "South and Central Asia-I, Official Scripts of India". The 9 scripts are Bengali, Devanagari, Gujarati, Gurmukhi, Kannada, Malayalam, Oriya, Tamil and Telugu. A lot of Indic Computing projects are going on. They involve some government sector companies, some volunteer groups and individual people. == Government sector == Indian Union Government made it mandatory for Mobile phone companies whose handsets manufactured, stored, sold and distributed in India to have support for displaying and typing text using fonts for all 22 languages. This move has seen rise in use of Indian languages by millions of users. === TDIL === The Department of Electronics and Information Technology, India initiated the TDIL (Technology Development for Indian Languages) with the objective of developing Information Processing Tools and Techniques to facilitate human-machine interaction without a language barrier; creating and accessing multilingual knowledge resources; and integrating them to develop innovative user products and services. In 2005, it started distributing language software tools developed by Government/Academic/Private companies in the form of CD for non commercial use. Some of the outcomes of TDIL program have been deployed on Indian Language Technology Proliferation & Deployment Centre. This Centre disseminates all the linguistic resources, tools & applications which have been developed under TDIL funding. This programme took to exponential expansion under the leadership of Dr. Swaran Lata who also created international foot-print of the programme. She has now retired. === C-DAC === C-DAC is an India based government software company which is involved in developing language related software. It is best known for developing InScript Keyboard, the standard keyboard for Indian languages. It has also developed lot of Indic language solutions including Word Processors, typing tools, text to speech software, OCR in Indian languages etc. ==== BharateeyaOO.org ==== The work developed out of CDAC, Bangalore (earlier known as NCST, Bangalore) became BharateeyaOO. OpenOffice 2.1 had support for over 10 Indian languages. ==== BOSS ==== BOSS linux was developed by the Centre for Development of Advanced Computing (CDAC) to promote use of open-source software in India. == NGO and Volunteer groups == === Indlinux === Indlinux organisation helped organise the individual volunteers working on different indic language versions of Linux and its applications. === Sarovar === Sarovar.org is India's first portal to host projects under Free/Open source licenses. It is located in Trivandrum, India and hosted at Asianet data center. Sarovar.org is customised, installed and maintained by Linuxense as part of their community services and sponsored by River Valley Technologies. Sarovar.org is built on Debian Etch and GForge and runs off METTLE. === Pinaak === Pinaak is a non-government charitable society devoted to Indic language computing. It works for software localization, developing language software, localizing open source software, enriching online encyclopedias etc. In addition to this Pinaak works for educating people about computing, ethical use of Internet and use of Indian languages on Internet. === Ankur Group === Ankur Group is working toward supporting Bengali language (Bengali) on Linux operating system including localized Bengali GUI, Live CD, English-to-Bengali translator, Bengali OCR and Bengali Dictionary etc. === BhashaIndia === === SMC === SMC is a free software group, working to bridge the language divide in Kerala in the technology front and is today the biggest language computing community in India. == Input methods == === Full size keyboards === With the advent of Unicode inputting Indic text on computer has become very easy. A number of methods exist for this purpose, but the main ones are:- ==== InScript ==== Inscript is the standard keyboard for Indian languages. Developed by C-DAC and standardized by Government of India. Nowadays it comes inbuilt in all major operating systems including Microsoft Windows (2000, XP, Vista, 7), Linux and Macintosh. ==== Phonetic transliteration ==== This is a typing method in which, for instance, the user types text in an Indian language using Roman characters and it is phonetically converted to equivalent text in Indian script in real time. This type of conversion is done by phonetic text editors, word processors and software plugins. Building up on the idea, one can use phonetic IME tools that allow Indic text to be input in any application. Some examples of phonetic transliterators are Xlit, Google Indic Transliteration, BarahaIME, Indic IME, Rupantar, SMC's Indic Keyboard and Microsoft Indic Language Input Tool. SMC's Indic Keyboard has support for as many as 23 languages whereas Google Indic Keyboard only supports 11 Indian languages. They can be broadly classified as: Fixed transliteration scheme based tools – They work using a fixed transliteration scheme to convert text. Some examples are Indic IME, Rupantar and BarahaIME. Intelligent/Learning based transliteration tools – They compare the word with a dictionary and then convert it to the equivalent words in the target language. Some of the popular ones are Google Indic Transliteration, Xlit, Microsoft Indic Language Input Tool and QuillPad. ==== Remington (typewriter) ==== This layout was developed when computers had not been invented or deployed with Indic languages, and typewriters were the only means to type text in Indic scripts. Since typewriters were mechanical and could not include a script processor engine, each character had to be placed on the keyboard separately, which resulted in a very complex and difficult to learn keyboard layout. With the advent of Unicode, the Remington layout was added to various typing tools for sake of backward compatibility, so that old typists did not have to learn a new keyboard layout. Nowadays this layout is only used by old typists who are used to this layout due to several years of usage. One tool to include Remington layout is Indic IME. A font that is based on the Remington keyboard layout is Kruti Dev. Another online tool that very closely supports the old Remington keyboard layout using Kruti Dev is the Remington Typing tool. === Braille === IBus Sharada Braille, which supports seven Indian languages was developed by SMC. === Mobile phones with Numeric keyboards === Mobile/Hand/cell phone basic models have 12 keys like the plain old telephone keypad. Each key is mapped to 3 or 4 English letters to facilitate data entry in English. For inputting Indian languages with this kind of keypad, there are two ways to do so. First is the Multi-tap Method and second uses visual help from the screen like Panini Keypad. The primary usage is SMS. 140 characters size used for English/Roman languages can be used to accommodate only about 70 language characters when Unicode Proprietary compression is used some times to increase the size of single message for Complex script languages like Hindi. A research study of the available methods and recommendations of proposed standard was released by Broadband Wireless Consortium of India (BWCI). ==== Transliteration/Phonetic methods ==== English is used to type in Indian languages. QuillPad IndiSMS ==== Native methods ==== In native methods, the letters of the language are displayed on the screen corresponding to the numeral keys based on the probabilities of those letters for that language. Additional letters can be accessed by using a special key. When a word is partially typed, options are presented from which the user can make a selection. === Smart phones with Qwerty keyboards === Most smart phones have about 35 keys catering primarily to the English language. Numerals and some symbols are accessed with a special key called Alt. Indic input methods are yet to evolve for these types of phones, as support of Unicode for rendering is not widely available. === For Smart Phones with Soft/Virtual keyboards === Inscript is being adopted for smart phone usage. For Android phones which can render Indic languages, Swalekh Multilingual Keypad Multiling Keyboard app are available. Gboard offers support for several Indian languages. == Localization == Localization means translating software, operating systems, websites etc. various applications in Indian language. Various volunteers groups are working in this direction. === Mandrake Tamil Version === A notable example is the Tamil version of Mandrake linux(defunct since 2011). Tamil speakers in Toronto (Canada) released Mandrake,
Visual descriptor
In computer vision, visual descriptors or image descriptors are descriptions of the visual features of the contents in images, videos, or algorithms or applications that produce such descriptions. They describe elementary characteristics such as the shape, the color, the texture or the motion, among others. == Introduction == As a result of the new communication technologies and the massive use of Internet in our society, the amount of audio-visual information available in digital format is increasing considerably. Therefore, it has been necessary to design some systems that allow us to describe the content of several types of multimedia information in order to search and classify them. The audio-visual descriptors are in charge of the contents description. These descriptors have a good knowledge of the objects and events found in a video, image or audio and they allow the quick and efficient searches of the audio-visual content. This system can be compared to the search engines for textual contents. Although it is relatively easy to find text with a computer, it is much more difficult to find concrete audio and video parts. For instance, imagine somebody searching a scene of a happy person. The happiness is a feeling and it is not evident its shape, color and texture description in images. The description of the audio-visual content is not a superficial task and it is essential for the effective use of this type of archives. The standardization system that deals with audio-visual descriptors is the MPEG-7 (Motion Picture Expert Group - 7). == Types == Descriptors are the first step to find out the connection between pixels contained in a digital image and what humans recall after having observed an image or a group of images after some minutes. Visual descriptors are divided in two main groups: General information descriptors: contain low level descriptors which give a description about color, shape, regions, textures and motion. Specific domain information descriptors: give information about objects and events in the scene. A concrete example would be face recognition. === General information descriptors === General information descriptors consist of a set of descriptors that covers different basic and elementary features like: color, texture, shape, motion, location and others. This description is automatically generated by means of signal processing. ==== Color ==== It's the most basic quality of visual content. Five tools are defined to describe color. The three first tools represent the color distribution and the last ones describe the color relation between sequences or group of images: Dominant color descriptor (DCD) Scalable color descriptor (SCD) Color structure descriptor (CSD) Color layout descriptor (CLD) Group of frame (GoF) or group-of-pictures (GoP) ==== Texture ==== It's an important quality in order to describe an image. The texture descriptors characterize image textures or regions. They observe the region homogeneity and the histograms of these region borders. The set of descriptors is formed by: Homogeneous texture descriptor (HTD) Texture browsing descriptor (TBD) Edge histogram descriptor (EHD) ==== Shape ==== It contains important semantic information due to human's ability to recognize objects through their shape. However, this information can only be extracted by means of a segmentation similar to the one that the human visual system implements. Nowadays, such a segmentation system is not available yet, however there exists a serial of algorithms which are considered to be a good approximation. These descriptors describe regions, contours and shapes for 2D images and for 3D volumes. The shape descriptors are the following ones: Region-based shape descriptor (RSD) Contour-based shape descriptor (CSD) 3-D shape descriptor (3-D SD) ==== Motion ==== It's defined by four different descriptors which describe motion in video sequence. Motion is related to the objects motion in the sequence and to the camera motion. This last information is provided by the capture device, whereas the rest is implemented by means of image processing. The descriptor set is the following one: Motion activity descriptor (MAD) Camera motion descriptor (CMD) Motion trajectory descriptor (MTD) Warping and parametric motion descriptor (WMD and PMD) ==== Location ==== Elements location in the image is used to describe elements in the spatial domain. In addition, elements can also be located in the temporal domain: Region locator descriptor (RLD) Spatio temporal locator descriptor (STLD) === Specific domain information descriptors === These descriptors, which give information about objects and events in the scene, are not easily extractable, even more when the extraction is to be automatically done. Nevertheless, they can be manually processed. As mentioned before, face recognition is a concrete example of an application that tries to automatically obtain this information. == Descriptors applications == Among all applications, the most important ones are: Multimedia documents search engines and classifiers. Digital library: visual descriptors allow a very detailed and concrete search of any video or image by means of different search parameters. For instance, the search of films where a known actor appears, the search of videos containing the Everest mountain, etc. Personalized electronic news service. Possibility of an automatic connection to a TV channel broadcasting a soccer match, for example, whenever a player approaches the goal area. Control and filtering of concrete audiovisual content, like violent or pornographic material. Also, authorization for some multimedia content.
Federal Virtual World Challenge
The Federal Virtual Challenge, formerly The Federal Virtual Worlds Challenge is a competition led by the Simulation and Training Technology Center (United States Army Research, Development and Engineering Command). The event is conducted in order to reach a global development community that will create innovative and interactive training and analysis services in virtual worlds. The inaugural event began in 2009 with the awards being conducted during March 2010 GameTech conference in Orlando, Florida. == Description == The focus of the challenge is training or analysis capability conducted wholly in a virtual environment. The training and analysis audience includes all United States Federal Agencies including, Department of Defense, Department of Homeland Security, Department of Transportation, and Department of Health and Human Services, NASA, DOT, and many more.
Supreme Commander (video game)
Supreme Commander (sometimes SupCom) is a 2007 real-time strategy video game designed by Chris Taylor and developed by his company, Gas Powered Games. The game is considered to be a spiritual successor, not a direct sequel, to Taylor's 1997 game Total Annihilation. First announced in the August 2005 edition of PC Gamer magazine, the game was released in Europe on February 16, 2007, and in North America on February 20. The standalone expansion Supreme Commander: Forged Alliance was released on November 6 of the same year. The sequel, Supreme Commander 2, was released in 2010. Nowadays, the original Supreme Commander is played through the community client called Forged Alliance Forever; the game has been further developed and balanced, and offers a wide variety of community mods. The gameplay of Supreme Commander focuses on using a giant bipedal mech called an Armored Command Unit (ACU), the so-called "Supreme Commander", to build a base, upgrading units to reach higher technology tiers, and conquering opponents. The player can command one of three factions: the Aeon Illuminate, the Cybran Nation, or the United Earth Federation (UEF). The expansion game added the Seraphim faction. Supreme Commander was highly anticipated in pre-release previews, and was well received by critics, with a Metacritic average of 86 out of 100. == Gameplay == Supreme Commander, like its spiritual predecessors, Total Annihilation and Spring, begins with the player solely possessing a single, irreplaceable construction unit called the "Armored Command Unit," or ACU, the titular Supreme Commander. Normally the loss of this unit results in the loss of the game (Skirmish missions can be set for a variety of victory conditions). These mech suits are designed to be transported through quantum gateways across the galaxy and contain all the materials and blueprints necessary to create an army from a planet's native resources in hours. All standard units except Commanders and summoned Support Commanders (sACU) are self-sufficient robots. All units and structures belong to one of four technology tiers, or "Tech" levels, each tier being stronger and/or more efficient than the previous. Certain lower-tier structures can be upgraded into higher ones without having to rebuild them. The first tier is available at the start of the game and consists of small, relatively weak units and structures. The second tier expands the player's abilities greatly, especially in terms of stationary weapons and shielding, and introduces upgraded versions of tier one units. The third tier level has very powerful assault units designed to overcome the fortifications of the most entrenched player. The fourth tier is a limited range of "experimental" technology. These are usually massive units which take a lot of time and energy to produce, but provide a significant tactical advantage. Supreme Commander features a varied skirmish AI. The typical Easy' and Normal modes are present, but the Hard difficulty level has four possible variants. Horde AI will swarm the player with hordes of lower level units, Tech AI will upgrade its units as fast as possible and assault the player with advanced units, the Balanced AI attempts to find a balance between the two, and the Supreme AI decides which of the three hard strategies is best for the map. The single player campaign consists of eighteen missions, six for each faction. The player is an inexperienced Commander who plays a key role in their faction's campaign to bring the "Infinite War" to an end. Despite the low number of campaign missions, each mission can potentially last hours. At the start of a mission, objectives are assigned for the player to complete. Once the player accomplishes them, the map is expanded, sometimes doubling or tripling in size, and new objectives are assigned. As the mission is commonly divided into three segments, the player will often have to overcome several enemy positions to achieve victory. === Resource management === Because humans have developed replication technology, making advanced use of rapid prototyping and nanotechnology, only two types of resources are required to wage war: Energy and Mass. Energy is obtained by constructing power generators on any solid surface (except fuel generators, which can only be built on fuel deposits), while Mass is obtained either by placing mass extractors on limited mass deposit spots (the most efficient method, although it requires map control) or by building mass fabricators to convert energy into mass. Constructor units can gather energy by "reclaiming" it from organic debris such as trees and mass from rocks and wrecked units. Each player has a certain amount of resource storage, which can be expanded by the construction of storage structures. This gives the player reserves in times of shortage or allows them to stockpile resources. If the resource generation exceeds the player's capacity, the material is wasted. On the contrary, if the storages are depleted and the demand of one of the resources exceeds the production, then all the productions speed is reduced. In addition, if an energy deficit occurs, shields will stop working. An adjacency system allows certain structures to benefit from being built directly adjacent to others. Energy-consuming structures will use less energy when built adjacent to power generators and power generators will produce more energy when built adjacent to power storage structures. The same applies to their mass-producing equivalents. Likewise, factories will consume less energy and mass when built adjacent to power generators and mass fabricators/extractors, respectively. However, by placing structures in close proximity, they become more vulnerable to collateral damage if an adjacent structure is destroyed. Furthermore, most resource generation structures can cause chain reactions when destroyed (especially Tier III structures, which produce large amounts of resources but often have large detonations that can wipe out a nearby army). === Warfare === Supreme Commander uses a "strategic zoom" system that allows the player to seamlessly zoom from a detailed close up view of an individual unit all the way out to a view of the entire map, at which point it resembles a fullscreen version of the minimap denoting individual units with icons. The camera also has a free movement mode and can be slaved to track a selected unit and there is a split screen mode which also supports multiple monitors. This system allows Supreme Commander to use vast maps up to 80 km x 80 km, with players potentially controlling a thousand units each. Units in Supreme Commander are built to scale as they would be in the real world. For example, battleships dwarf submarines. Late into the game, the larger "experimental" units, such as the Cybran Monkeylord, an enormous spider-shaped assault unit, can actually crush smaller enemy units by stepping on them. Because of the wide range of planets colonized by humanity in the setting, the theatres of war range from desert to arctic, and all battlespaces are employed. Technologies emerging in modern warfare are frequently employed in Supreme Commander. For example, stealth technology and both tactical and strategic missile and missile defense systems can be used. Supreme Commander introduced several innovations designed to reduce the amount of micromanagement inherent in many RTS games. Engineers units have the command "assist", that will help follow other engineers and help them finish their orders or improve production rate of factories. In addition, engineers with the order "patrol" will repair units, buildings and recycle wrecks in their along their patrol route. Holding the shift key causes any orders given to a unit (or group of units) to be queued. In this manner a unit may be ordered to attack several targets in succession, or to make best speed to a given point on the map and then attack towards a specified location engaging any hostiles it encounters along the way. After orders have been issued, holding the shift key causes all issued orders to be displayed on the map where they can be subsequently modified to accommodate a change of plan. Further, when a unit is ordered to attack a target, the player can issue an order to perform a coordinated attack to another unit. This order coordinates the arrival time of the units at the target automatically by adjusting the speed of the units involved. As in other RTS games, air transports can be used to convey units to specified destinations, in Supreme Commander though by shift queuing orders a transport containing several units can be ordered to drop specific units at subsequent waypoints. An air transport can also be ordered to create a ferry route, an airbridge wherein any land units ordered to the start of the ferry route will be conveyed by the air transport to the specified destination. The output from a production factory can be routed to a ferry route causing all units co
The Great Automatic Grammatizator
The Great Automatic Grammatizator (published in the U.S. as The Umbrella Man and Other Stories) is a posthumous 1998 collection of thirteen short stories written by British author Roald Dahl. The stories were selected for teenagers from Dahl's adult works. All the stories included were published elsewhere originally; their sources are noted below. The stories, with the exception of the war story "Katina", possess a deadpan, ironic, bizarre, or even macabre sense of humor. They generally end with unexpected plot twists. == Stories == "The Great Automatic Grammatizator" (from Someone Like You): A mechanically-minded man reasons that the rules of grammar are fixed by certain, almost mathematical principles. By exploiting this idea, he is able to create a mammoth machine that can write a prize-winning novel in roughly fifteen minutes. The story ends on a fearful note, as more and more of the world's writers are forced into licensing their names—and all hope of human creativity—to the machine. "Mrs. Bixby and the Colonel's Coat" (from Kiss Kiss): Mrs. Bixby cheats on her dentist husband with a rich, dashing colonel. When their relationship breaks off, the colonel offers Mrs. Bixby a gorgeous and expensive mink coat. In an attempt to explain the coat away, Mrs. Bixby sets up an elaborate trick with the help of a pawn shop—but her husband learns of the ruse and manages to turn the tables. "The Butler" (from More Tales of the Unexpected): An obnoxious and newly wealthy couple employs a butler and chef to impress dinner guests. The butler recommends that the husband buy expensive wines to please his guests, and the man slavishly follows the idea. The butler and the chef reap the rewards of this idea, while making fools of the "fashionable" couple. "Man from the South" (from Someone Like You): At a seaside resort in Jamaica, a strange old man makes a bet with an American man in his late teens. If the young man's cigarette lighter can spark ten times without fail, the American will win a brand-new Cadillac car—but failure means losing the little finger of his right hand. The high-tension wager ensues, and with only a few sparks left, a woman—who knows only too well the cost of the old man's bets—appears and stops the madness. "The Landlady" (from Kiss Kiss): A young man traveling to London on business stops at a bed and breakfast along the way, where a strange and slightly dotty landlady eagerly welcomes him. The eccentric nature of the house, and the news that only two other young men have ever stayed there, confuse and frighten the young man. In the end, the landlady—who indulges in the hobby of taxidermy—and the boy share a drink of tea that tastes of bitter almonds, and the landlady softly smiles at what may be her latest stuffing project. "Parson's Pleasure" (from Kiss Kiss): A man discovers an extremely rare piece of Chippendale furniture at the farm of some boorish ranchers. He desperately attempts to buy the piece cheap, in the hope of selling it at auction to earn a huge profit. He manages to buy the piece "for firewood", only for the ranchers to destroy it in an attempt to make it fit into his car. "The Umbrella Man" (from More Tales of the Unexpected): On a rainy day, a mother and daughter meet a gentlemanly old man on a street corner, who offers them a beautiful silk umbrella in exchange for a pound note. They trade, and the daughter notices that the "feeble" old man suddenly seems much sprier. They follow him, and discover that the gentleman is a con artist who visits various pubs, has a drink, and then steals another umbrella to continue the cycle. "Katina" (from Over to You: Ten Stories of Flyers and Flying): A group of RAF pilots stationed in Greece during World War II discover a hauntingly beautiful young girl, whose "family is beneath the rubble." She becomes their squadron's unofficial "mascot". In the end, her fragile life is taken as she stands defiantly against a rain of bullets from Nazi aircraft, shaking her fists at the heavens. "The Way Up to Heaven" (from Kiss Kiss): Mrs. Foster suffers from a chronic phobia of being late for appointments. Her husband enjoys the cruel sport of purposely delaying their activities, just to rile his wife. On the day when Mrs. Foster is due to fly to Paris to visit her grandchildren, her husband engages in his usual tricks. But as Mrs. Foster rushes from their taxi to the house to find him, she hears a strange noise—and turns triumphantly toward her cab. It is only when she returns, and calls a man to "repair the lift" that was stuck between floors in the house, that readers guess Mr. Foster's fate. "Royal Jelly" (from Kiss Kiss): New parents fear for the life of their little girl, who is sickly and dangerously underweight. The husband, a beekeeper, remembers hearing of the miraculous royal jelly used by bees to transform one particular larva into a queen. He adds the mixture to his daughter's bottles, and she puts on weight at an astonishing rate. The mother senses that something is amiss, and the husband confesses his actions—along with the fact that he himself swallowed buckets of the jelly for months in an attempt to cure his impotence. The royal jelly did the trick—but the strange side-effects include a disturbing metamorphosis for both father and daughter. "Vengeance is Mine Inc." (from More Tales of the Unexpected): Two brothers who are short of cash bemoan their fate over breakfast while reading the society column of a newspaper. They hit upon a scheme to take revenge on cruel tabloid writers in exchange for money from wealthy patrons. The unconventional plan works, and the brothers line their pockets with the spoils of their plans. "Taste" (from Someone Like You): A rich man with a beautiful young daughter hosts a dinner party, inviting a famous connoisseur of fine wines. When the rich man boasts that he has a wine that the expert cannot identify, the stakes become frighteningly high: if he can guess the name and vintage of the wine, he will win his daughter's hand. After an elaborate show, the expert guesses correctly; however, the family's maid appears and inadvertently exposes the guest as a cheat, thus saving the girl. "Neck" (from Someone Like You): A newspaper heir finds himself suddenly engaged to the voluptuous and controlling Lady Tutton. He loses all control of his life, and only his trusted butler and friends realize how broken he is by her control. A weekend trip to their estate, however, proves the perfect opportunity for Lord Tutton to engage in revenge against his wicked wife: her head is trapped in a valuable piece of wooden sculpture, and he must decide whether to use a saw or an axe to cut her free. == Publication details == Dahl, Roald (19 January 2004). The Umbrella Man and Other Stories. Speak. ISBN 9780142400876. == Reception == Groff Conklin in 1954 called the short story "The Great Automatic Grammatizator" "an awe-inspiring fantasy-satire ... an unforgettable bit of biting nonsense".
Shadow and highlight enhancement
Shadow and highlight enhancement refers to an image processing technique used to correct exposure. The use of this technique has been gaining popularity, making its way onto magazine covers, digital media, and photos. It is, however, considered by some to be akin to other destructive Photoshop filters, such as the Watercolor filter, or the Mosaic filter. == Shadow recovery == A conservative application of the shadow/highlight tool can be very useful in recovering shadows, though it tends to leave a telltale halo around the boundary between highlight and shadow if used incorrectly. A way to avoid this is to use the bracketing technique, although this usually requires a tripod. == Highlight recovery == Recovering highlights with this tool, however, has mixed results, especially when using it on images with skin in them, and often makes people look like they have been "sprayed with fake tan". == Shadow brightening - manual == One way to brighten shadows in image editing software such as GIMP or Adobe Photoshop is to duplicate the background layer, invert the copy and set the blend modes of that top layer to "Soft Light". You can also use an inverted black and white copy of the image as a mask on a brightening layer, such as Curves or Levels. == Shadow brightening - automatic == Several automatic computer image processing-based shadow recovery and dynamic range compression methods can yield a similar effect. Some of these methods include the retinex method and homomorphic range compression. The retinex method is based on work from 1963 by Edwin Land, the founder of Polaroid. Shadow enhancement can also be accomplished using adaptive image processing algorithms such as adaptive histogram equalization or contrast limiting adaptive histogram equalization (CLAHE).
Resistance Database Initiative
HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.