GeneTalk is a web-based platform, tool, and database for filtering, reduction and prioritization of human sequence variants from next-generation sequencing (NGS) data. GeneTalk allows editing annotation about sequence variants and build up a crowd sourced database with clinically relevant information for diagnostics of genetic disorders. GeneTalk allows searching for information about specific sequence variants and connects to experts on variants that are potentially disease-relevant. == Application to diagnostics == Users can upload NGS data in Variant Call Format (VCF) onto the GeneTalk server into their accounts. All entries of the file are preprocessed and shown in the integrated VCF viewer. Filtering tools are set by the user to reduce the number of clinically non-relevant variants. After filtering and prioritization users can interpret relevant variants by retrieving information (annotations) about variants from the GeneTalk database. The communication platform allow users to contact experts about specific variants, genes, or genetic disorders, to exchange knowledge and expertise. === Analysis procedure === Steps required to analyze VCF files Upload VCF file Edit pedigree and phenotype information for segregation filtering Filter VCF file by editing the filtering options View results and annotations Add annotations === Filtering tools === The following filtering options may be used to reduce the non-relevant sequence variants in VCF files. Functional – filter out variants that have effects on protein level Linkage – filter out variants that are on specified chromosomes Gene panel – filter variants by genes or gene panels, subscribe to publicly available gene panels or create own ones Frequency – show only variants with a genotype frequency lower than specified Inheritance – filter out variants by presumed mode of inheritance Annotation – show only variants with a score for medical relevance and scientific evidence == Communication platform and expert network == Users can share VCF files with colleagues and coworkers. The integrated mailing systems allows users to contact experts easily. Users can create annotations and comments and rate annotations regarding medical relevance and scientific evidence, that is helpful for the community of users for diagnosis of genetic disorders. Registered users provide information about their field of knowledge in their profile and can be contacted by other users. == Potential applications == Developing diagnostics Genetic analysis Capturing data generated by community Communication and exchange of knowledge and expertise
Patent visualisation
Patent visualisation is an application of information visualisation. The number of patents has been increasing, encouraging companies to consider intellectual property as a part of their strategy. Patent visualisation, like patent mapping, is used to quickly view a patent portfolio. Software dedicated to patent visualisation began to appear in 2000, for example Aureka from Aurigin (now owned by Thomson Reuters). Many patent and portfolio analytics platforms, such as Questel, Patent Forecast, PatSnap, Patentcloud, Relecura, and Patent iNSIGHT Pro, offer options to visualise specific data within patent documents by creating topic maps, priority maps, IP Landscape reports, etc. Software converts patents into infographics or maps, to allow the analyst to "get insight into the data" and draw conclusions. Also called patinformatics, it is the "science of analysing patent information to discover relationships and trends that would be difficult to see when working with patent documents on a one-and-one basis". Patents contain structured data (like publication numbers) and unstructured text (like title, abstract, claims and visual info). Structured data are processed by data-mining and unstructured data are processed with text-mining. == Data mining == The main step in processing structured information is data-mining, which emerged in the late 1980s. Data mining involves statistics, artificial intelligence, and machine learning. Patent data mining extracts information from the structured data of the patent document. These structured data are bibliographic fields such as location, date or status. === Structured fields === === Advantages === Data mining allows study of filing patterns of competitors and locates main patent filers within a specific area of technology. This approach can be helpful to monitor competitors' environments, moves and innovation trends and gives a macro view of a technology status. == Text-mining == === Principle === Text mining is used to search through unstructured text documents. This technique is widely used on the Internet, it has had success in bioinformatics and now in the intellectual property environment. Text mining is based on a statistical analysis of word recurrence in a corpus. An algorithm extracts words and expressions from title, summary and claims and gathers them by declension. "And" and "if" are labeled as non-information bearing words and are stored in the stopword list. Stoplists can be specialised in order to create an accurate analysis. Next, the algorithm ranks the words by weight, according to their frequency in the patent's corpus and the document frequency containing this word. The score for each word is calculated using a formula such as: W e i g h t = T e r m F r e q u e n c y D o c u m e n t F r e q u e n c y = F r e q u e n c y o f t h e w o r d o r e x p r e s s i o n i n t h e T e x t S e a N u m b e r o f d o c u m e n t s c o n t a i n i n g t h e e x p r e s s i o n o r w o r d {\displaystyle Weight={\frac {Term\ Frequency}{Document\ Frequency}}={\frac {Frequency\ of\ the\ word\ or\ expression\ in\ the\ Text\ Sea}{Number\ of\ documents\ containing\ the\ expression\ or\ word}}} A frequently used word in several documents has less weight than a word used frequently in a few patents. Words under a minimum weight are eliminated, leaving a list of pertinent words or descriptors. Each patent is associated to the descriptors found in the selected document. Further, in the process of clusterisation, these descriptors are used as subsets, in which the patent are regrouped or as tags to place the patents in predetermined categories, for example keywords from International Patent Classifications. Four text parts can be processed with text-mining : Title Abstract Claim Patent Full-Text Software offer different combinations but title, abstract and claim are generally the most used, providing a good balance between interferences and relevancy. === Advantages === Text-mining can be used to narrow a search or quickly evaluate a patent corpus. For instance, if a query produces irrelevant documents, a multi-level clustering hierarchy identifies them in order to delete them and refine the search. Text-mining can also be used to create internal taxonomies specific to a corpus for possible mapping. == Visualisations == Allying patent analysis and informatic tools offers an overview of the environment through value-added visualisations. As patents contain structured and unstructured information, visualisations fall in two categories. Structured data can be rendered with data mining in macrothematic maps and statistical analysis. Unstructured information can be shown in like clouds, cluster maps and 2D keyword maps. === Data mining visualisation === === Text mining visualisation === === Visualisation for both data-mining and text-mining === Mapping visualisations can be used for both text-mining and data-mining results. == Uses == What patent visualisation can highlight: Competitors Partners New innovations Technologic environment description Networks Field application: R&D strategy management Competitive intelligence Licensing Strategy
Vujak
VuJak is an early video sampler, a VJ remix and mashup tool created in 1992 by Brian Kane, Lisa Eisenpresser, and Jay Haynes. The original name of the project was Mideo, but it was later changed to VuJak. VuJak was based on MIDI control of video in real-time. It was created with MAX from Opcode Systems, and utilized the newly released QuickTime 1.0 movie object. The first working version of the program was built on a Mac IIfx with 8 megs of ram, and could jump in real-time across a 160 x 120 pixel QuickTime movie via a midi keyboard. Later versions could manipulate full screen video, included the first real-time video scratch feature, had looping, vari-speed, and random play features, and allowed for recording and editing of video sequences within the application. VuJak also had networking capabilities which allowed artists to "jam" in real time across standard phone lines. The first public exhibition of VuJak was at the Digital Hollywood conference in Beverly Hills in 1993, where it was promoted by Timothy Leary. VuJak was featured in Mondo 2000, CBS Evening News, Wired Magazine, Electronic Musician, Billboard Magazine, The Hollywood Reporter, and it was used to create promotional videos for MTV. In 1994, VuJak was a featured interactive exhibition at the Exploratorium in San Francisco. Development of VuJak ceased in 1995.
Find It, Fix It
Find It, Fix It is a mobile app developed by the city of Seattle to report non-emergency issues. == History == The City of Seattle launched Find It, Fix It in 2013 for Android and iOS phones to let citizens report potholes, graffiti, and other problems they observe to the city. The app did not support Windows Phone, making it inaccessible to Microsoft employees in the city who used the company's then-supported mobile operating system. In 2015, Mayor Ed Murray led a Find It, Fix It walk with about 100 other people, including police officers, in the University District. Participants were encouraged to use the app to report problems they observed in the neighborhood. Later Find It, Fix It walks have taken place in neighborhoods including Crown Hill, First Hill, Belltown, Wallingford, and Highland Park. In 2020, Find It, Fix It added support for reporting issues with the dockless bicycle sharing systems in the city. Citing the success of Seattle’s app, the nearby city of Kent, Washington, announced that it would create a similar customer service app. == Usage == Users of Find It, Fix It can submit reports about graffiti, potholes, parking violations, broken street signs, and other issues. The app is designed to use a smartphone’s camera and GPS features to make it easier for users to file reports. The Atlantic reported in 2018 that Find It, Fix It was being used by neighborhood groups to report homeless encampments with the intention of having authorities remove them, citing examples of campaigns in Ravenna and Ballard. The executive director of Ballard Alliance, a local chamber of commerce for businesses in the neighborhood, used a private Facebook group to encourage business owners to use the app to report homeless encampments. In response to a poster campaign in the summer of 2019 with the slogan “See a tent? Report a tent”, a representative for the mayor’s office and two Seattle City Council members said that it was inappropriate to encourage use of Find It, Fix It to displace homeless people. As a backlash to these campaigns, people living far from Seattle filed hoax complaints using the app, such as by using photos of tents on display at REI stores. According to the Seattle Times, between January 1, 2020, and November 15, 2021, the city had received over 230,000 service requests, of which 77% were submitted via Find It, Fix It. The largest category of these, numbering over 55,000, concerned illegal dumping. Of complaints categorized as "parking", 3,000 had comments explicitly mentioning issues around homelessness. The ZIP code 98134, covering an industrial area south of Pioneer Square and north of Georgetown, had 5,559 service requests per 1,000 residents, by far the highest in the city.
PressWise
PressWise was digital imposition software to quickly and easily impose most any variety of flat and folding layouts. It was acquired by the Aldus Prepress Group affectionately known in the print and publishing industry as the Aldus WiseGuys in August 1991 from Emulation Technologies Inc. of Cleveland, Ohio. It was further developed by the Aldus Press Group and launched as the first of many Aldus prepress products in 1993. It was subsequently owned by Adobe Systems, then Luminous Corporation (Seattle), then Imation, and finally ScenicSoft. PressWise was discontinued by ScenicSoft in 1999 ultimately. == History == In February 2009, the PressWise copyright was acquired by Aethos Technologies and a new print automation product was launched by its creator, Eric Wold of Santa Rosa, California. This new product has no relationship to the old imposition software of the same name. It's notable that Larry Letteney, former President of Creo Americas was a board member and shareholder of Aethos Technologies during its early phase. Datatech SmartSoft acquired exclusive distribution rights to the software in September 2009. In September 2010 Datatech SmartSoft completed the acquisition of the PressWise brand and product.
Clarizen
Clarizen, Inc. is a project management software and collaborative work management company. Clarizen uses a software as a service business model. Clarizen's features include attaching CAD drawings to a project, moving between the project view and design view and an E-mail reporting feature. In May 2014 Clarizen raised $35 million in venture capital investment led by Goldman Sachs. The round brought investment to $90 million. Previous investors, including Benchmark Capital, Carmel Ventures, DAG Ventures, Opus Capital and Vintage Investment Partners participated. In April 2020, Clarizen appointed Matt Zilli as its new CEO, replacing Boaz Chalamish who is appointed as Executive Chairman. In January 2021 Clarizen was acquired by Planview.
Color picker
A color picker (also color chooser or color tool) is a graphical user interface widget, usually found within graphics software or online, used to select colors and, in some cases, to create color schemes (the color picker might be more sophisticated than the palette included with the program). Operating systems such as Microsoft Windows or macOS have a system color picker, which can be used by third-party programs (e.g., Adobe Photoshop). == History == The concept of color pickers dates back to the early days of computer graphics and digital design. Early versions were rudimentary, often featuring basic color palettes and limited functionality. One of the first drawing programs to include a color picker was SketchPad (also referred to as LisaSketch), designed by Bill Atkinson in 1983 to showcase LisaGraf's capabilities. It used a black and white pattern system, using dithering to create the illusion of color depth. With the increased popularity of personal computers with color graphics, there soon came software similar to SketchPad that supported more than two colors, like Broderbund's Dazzle Draw for the Apple II or Electronic Arts' Deluxe Paint. However, the color pickers present in those programs relied on indexed colors. Color pickers, resembling ones used in modern software with support for direct, 24-bit color, appeared soon after the release of the Macintosh II, with the release of programs like Adobe Photoshop and Corel Painter. As the increase of color depth allowed the choice of significantly more colors, the shape and form of color pickers started to diverge. For example, Adobe Photoshop used a hue-saturation color wheel with a slider for brightness in version 0.63, later on switching to a rectangular design accompanied by a hue slider. Corel Painter pioneered the triangular saturation and brightness picker with a hue ring around it, aiming to better represent the continuity of the hue spectrum and the relationship between saturation and brightness. == Purpose == A color picker is used to select and adjust color values. In graphic design and image editing, users typically choose colors via an interface with a visual representation of a color—organized with quasi-perceptually-relevant hue, saturation and lightness dimensions (HSL) – instead of keying in alphanumeric text values. Because color appearance depends on comparison of neighboring colors (see color vision), many interfaces attempt to clarify the relationships between colors. == Interface == Color tools can vary in their interface. Some may use sliders, buttons, text boxes for color values, or direct manipulation. Often a two-dimensional square is used to create a range of color values (such as lightness and saturation) that can be clicked on or selected in some other manner. Drag and drop, color droppers, and various other forms of interfaces are commonly used as well. Usually, color values are also displayed numerically, so they can be precisely remembered and keyed-in later, such as three values of 0-255 representing red, green, and blue, respectively. === Eyedropper === The eyedropper is a tool present in most color pickers and graphics software that allows a user to read a color at a specific point in an image, or position on a display. This enables the color to be transferred to other applications particularly quickly. Modern implementations of eyedropper tools are also available as browser extensions, allowing users to pick colors directly from web pages, such as in Google Chrome and Microsoft Edge. == Working == A color picker has two main parts, first a color slider and second a color canvas. The color slider has a linear or radial gradient of the seven rainbow colors i.e. Violet, Indigo, Blue, Green, Yellow, Orange and Red. It allows one to choose any of the seven primary colors. The color value chosen from the color slider instantly reflects in the color canvas. The color canvas is a mixture of two linear color gradients. First a linear gradient of the current chosen color and second a linear gradient of the black color. This mixture of color gradients lets one choose a lighter and darker version of the current chosen color from the color slider.