Inception is a family of convolutional neural network (CNN) for computer vision, introduced by researchers at Google in 2014 as GoogLeNet (later renamed Inception v1). The series was historically important as an early CNN that separates the stem (data ingest), body (data processing), and head (prediction), an architectural design that persists in all modern CNN. == Version history == === Inception v1 === In 2014, a team at Google developed the GoogLeNet architecture, an instance of which won the ImageNet Large-Scale Visual Recognition Challenge 2014 (ILSVRC14). The name came from the LeNet of 1998, since both LeNet and GoogLeNet are CNNs. They also called it "Inception" after a "we need to go deeper" internet meme, a phrase from Inception (2010) the film. Because later, more versions were released, the original Inception architecture was renamed again as "Inception v1". The models and the code were released under Apache 2.0 license on GitHub. The Inception v1 architecture is a deep CNN composed of 22 layers. Most of these layers were "Inception modules". The original paper stated that Inception modules are a "logical culmination" of Network in Network and (Arora et al, 2014). Since Inception v1 is deep, it suffered from the vanishing gradient problem. The team solved it by using two "auxiliary classifiers", which are linear-softmax classifiers inserted at 1/3-deep and 2/3-deep within the network, and the loss function is a weighted sum of all three: L = 0.3 L a u x , 1 + 0.3 L a u x , 2 + L r e a l {\displaystyle L=0.3L_{aux,1}+0.3L_{aux,2}+L_{real}} These were removed after training was complete. This was later solved by the ResNet architecture. The architecture consists of three parts stacked on top of one another: The stem (data ingestion): The first few convolutional layers perform data preprocessing to downscale images to a smaller size. The body (data processing): The next many Inception modules perform the bulk of data processing. The head (prediction): The final fully-connected layer and softmax produces a probability distribution for image classification. This structure is used in most modern CNN architectures. === Inception v2 === Inception v2 was released in 2015, in a paper that is more famous for proposing batch normalization. It had 13.6 million parameters. It improves on Inception v1 by adding batch normalization, and removing dropout and local response normalization which they found became unnecessary when batch normalization is used. === Inception v3 === Inception v3 was released in 2016. It improves on Inception v2 by using factorized convolutions. As an example, a single 5×5 convolution can be factored into 3×3 stacked on top of another 3×3. Both has a receptive field of size 5×5. The 5×5 convolution kernel has 25 parameters, compared to just 18 in the factorized version. Thus, the 5×5 convolution is strictly more powerful than the factorized version. However, this power is not necessarily needed. Empirically, the research team found that factorized convolutions help. It also uses a form of dimension-reduction by concatenating the output from a convolutional layer and a pooling layer. As an example, a tensor of size 35 × 35 × 320 {\displaystyle 35\times 35\times 320} can be downscaled by a convolution with stride 2 to 17 × 17 × 320 {\displaystyle 17\times 17\times 320} , and by maxpooling with pool size 2 × 2 {\displaystyle 2\times 2} to 17 × 17 × 320 {\displaystyle 17\times 17\times 320} . These are then concatenated to 17 × 17 × 640 {\displaystyle 17\times 17\times 640} . Other than this, it also removed the lowest auxiliary classifier during training. They found that the auxiliary head worked as a form of regularization. They also proposed label-smoothing regularization in classification. For an image with label c {\displaystyle c} , instead of making the model to predict the probability distribution δ c = ( 0 , 0 , … , 0 , 1 ⏟ c -th entry , 0 , … , 0 ) {\displaystyle \delta _{c}=(0,0,\dots ,0,\underbrace {1} _{c{\text{-th entry}}},0,\dots ,0)} , they made the model predict the smoothed distribution ( 1 − ϵ ) δ c + ϵ / K {\displaystyle (1-\epsilon )\delta _{c}+\epsilon /K} where K {\displaystyle K} is the total number of classes. === Inception v4 === In 2017, the team released Inception v4, Inception ResNet v1, and Inception ResNet v2. Inception v4 is an incremental update with even more factorized convolutions, and other complications that were empirically found to improve benchmarks. Inception ResNet v1 and v2 are both modifications of Inception v4, where residual connections are added to each Inception module, inspired by the ResNet architecture. === Xception === Xception ("Extreme Inception") was published in 2017. It is a linear stack of depthwise separable convolution layers with residual connections. The design was proposed on the hypothesis that in a CNN, the cross-channels correlations and spatial correlations in the feature maps can be entirely decoupled. Training each network took 3 days on 60 K80 GPUs, or approximately 0.5 petaFLOP-days.
Anti-Grain Geometry
Anti-Grain Geometry (AGG) is a 2D rendering graphics library written in C++. It features anti-aliasing and sub-pixel resolution. It is not a graphics library, per se, but rather a framework to build a graphics library upon. The library is operating system independent and renders to an abstract memory object. It comes with examples interfaced to the X Window System, Microsoft Windows, Mac OS X, AmigaOS, BeOS, SDL. The examples also include an SVG viewer. The design of AGG uses C++ templates only at a very high level, rather than extensively, to achieve the flexibility to plug custom classes into the rendering pipeline, without requiring a rigid class hierarchy, and allows the compiler to inline many of the method calls for high performance. For a library of its complexity, it is remarkably lightweight: it has no dependencies above the standard C++ libraries and it avoids the C++ STL in the implementation of the basic algorithms. The implicit interfaces are not well documented, however, and this can make the learning process quite cumbersome. While AGG version 2.5 is licensed under the GNU General Public License, version 2 or greater, AGG version 2.4 is still available under the 3-clause BSD license and is virtually the same as version 2.5. == History == Active development of the AGG codebase stalled in 2006, around the time of the v2.5 release, due to shifting priorities of its main developer and maintainer Maxim Shemanarev. M. Shemanarev remained active in the community until his sudden death in 2013. Development has continued on a fork of the more liberally licensed v2.4 on SourceForge.net. == Usage == The Haiku operating system uses AGG in its windowing system. It is one of the renderers available for use in GNU's Gnash Flash player. Graphical version of Rebol language interpreter is using AGG for scalable vector graphics DRAW dialect. Hilti uses it in some of their rebar detection tools, like the PS 1000. Matplotlib uses AGG as its canonical renderer for interactive user interfaces. fpGUI Toolkit has an optional AggPas back-end rendering engine. Work is being done to make AggPas the default or sole rendering engine for fpGUI. Mapnik, the toolkit that renders the maps on the OpenStreetMap website, uses AGG for all its bitmap map rendering by default. HTTPhotos uses AGG to scale photos. Pdfium, the PDF rendering engine used by Google Chrome makes use of AGG, although work is progressing to replace this with Skia Graphics Engine. Graphics Mill, the .NET imaging SDK uses AGG as its drawing engine. Image-Line FL Studio, a digital audio workstation, since version 10.8 released on September 30, 2012, uses AGG for drawing. Native Instruments's Supercharger and Supercharger GT compressors use AGG for its user interface. == Author == The main author of the library was Maxim Shemanarev (Russian: Максим Шеманарёв). On November 26, 2013 Shemanarev (born June 15, 1966, Nizhny Novgorod, Russia) was reported dead at the age of 47 at his home in Columbia, Maryland (US). He died suddenly, allegedly from an epileptic seizure that he had suffered for a while. He was a graduate from Nizhny Novgorod State Technical University. Little is known about his personal life. It's known though that he was divorced and his mother was alive at the time of his death. He used to love skiing, snowboarding (in Colorado), and inline skating. He was praised by his friends for his intelligent programming skills.
Computer audition
Computer audition (CA) or machine listening is the general field of study of algorithms and systems for audio interpretation by machines. Since the notion of what it means for a machine to "hear" is very broad and somewhat vague, computer audition attempts to bring together several disciplines that originally dealt with specific problems or had a concrete application in mind. The engineer Paris Smaragdis, interviewed in Technology Review, talks about these systems — "software that uses sound to locate people moving through rooms, monitor machinery for impending breakdowns, or activate traffic cameras to record accidents." Inspired by models of human audition, CA deals with questions of representation, transduction, grouping, use of musical knowledge and general sound semantics for the purpose of performing intelligent operations on audio and music signals by the computer. Technically this requires a combination of methods from the fields of signal processing, auditory modelling, music perception and cognition, pattern recognition, and machine learning, as well as more traditional methods of artificial intelligence for musical knowledge representation. == Applications == Like computer vision versus image processing, computer audition versus audio engineering deals with understanding of audio rather than processing. It also differs from problems of speech understanding by machine since it deals with general audio signals, such as natural sounds and musical recordings. Applications of computer audition are widely varying, and include search for sounds, genre recognition, acoustic monitoring, music transcription, score following, audio texture, music improvisation, emotion in audio and so on. == Related disciplines == Computer Audition overlaps with the following disciplines: Music information retrieval: methods for search and analysis of similarity between music signals. Auditory scene analysis: understanding and description of audio sources and events. Computational musicology and mathematical music theory: use of algorithms that employ musical knowledge for analysis of music data. Computer music: use of computers in creative musical applications. Machine musicianship: audition driven interactive music systems. == Areas of study == Since audio signals are interpreted by the human ear–brain system, that complex perceptual mechanism should be simulated somehow in software for "machine listening". In other words, to perform on par with humans, the computer should hear and understand audio content much as humans do. Analyzing audio accurately involves several fields: electrical engineering (spectrum analysis, filtering, and audio transforms); artificial intelligence (machine learning and sound classification); psychoacoustics (sound perception); cognitive sciences (neuroscience and artificial intelligence); acoustics (physics of sound production); and music (harmony, rhythm, and timbre). Furthermore, audio transformations such as pitch shifting, time stretching, and sound object filtering, should be perceptually and musically meaningful. For best results, these transformations require perceptual understanding of spectral models, high-level feature extraction, and sound analysis/synthesis. Finally, structuring and coding the content of an audio file (sound and metadata) could benefit from efficient compression schemes, which discard inaudible information in the sound. Computational models of music and sound perception and cognition can lead to a more meaningful representation, a more intuitive digital manipulation and generation of sound and music in musical human-machine interfaces. The study of CA could be roughly divided into the following sub-problems: Representation: signal and symbolic. This aspect deals with time-frequency representations, both in terms of notes and spectral models, including pattern playback and audio texture. Feature extraction: sound descriptors, segmentation, onset, pitch and envelope detection, chroma, and auditory representations. Musical knowledge structures: analysis of tonality, rhythm, and harmonies. Sound similarity: methods for comparison between sounds, sound identification, novelty detection, segmentation, and clustering. Sequence modeling: matching and alignment between signals and note sequences. Source separation: methods of grouping of simultaneous sounds, such as multiple pitch detection and time-frequency clustering methods. Auditory cognition: modeling of emotions, anticipation and familiarity, auditory surprise, and analysis of musical structure. Multi-modal analysis: finding correspondences between textual, visual, and audio signals. === Representation issues === Computer audition deals with audio signals that can be represented in a variety of fashions, from direct encoding of digital audio in two or more channels to symbolically represented synthesis instructions. Audio signals are usually represented in terms of analogue or digital recordings. Digital recordings are samples of acoustic waveform or parameters of audio compression algorithms. One of the unique properties of musical signals is that they often combine different types of representations, such as graphical scores and sequences of performance actions that are encoded as MIDI files. Since audio signals usually comprise multiple sound sources, then unlike speech signals that can be efficiently described in terms of specific models (such as source-filter model), it is hard to devise a parametric representation for general audio. Parametric audio representations usually use filter banks or sinusoidal models to capture multiple sound parameters, sometimes increasing the representation size in order to capture internal structure in the signal. Additional types of data that are relevant for computer audition are textual descriptions of audio contents, such as annotations, reviews, and visual information in the case of audio-visual recordings. === Features === Description of contents of general audio signals usually requires extraction of features that capture specific aspects of the audio signal. Generally speaking, one could divide the features into signal or mathematical descriptors such as energy, description of spectral shape etc., statistical characterization such as change or novelty detection, special representations that are better adapted to the nature of musical signals or the auditory system, such as logarithmic growth of sensitivity (bandwidth) in frequency or octave invariance (chroma). Since parametric models in audio usually require very many parameters, the features are used to summarize properties of multiple parameters in a more compact or salient representation. === Musical knowledge === Finding specific musical structures is possible by using musical knowledge as well as supervised and unsupervised machine learning methods. Examples of this include detection of tonality according to distribution of frequencies that correspond to patterns of occurrence of notes in musical scales, distribution of note onset times for detection of beat structure, distribution of energies in different frequencies to detect musical chords and so on. === Sound similarity and sequence modeling === Comparison of sounds can be done by comparison of features with or without reference to time. In some cases an overall similarity can be assessed by close values of features between two sounds. In other cases when temporal structure is important, methods of dynamic time warping need to be applied to "correct" for different temporal scales of acoustic events. Finding repetitions and similar sub-sequences of sonic events is important for tasks such as texture synthesis and machine improvisation. === Source separation === Since one of the basic characteristics of general audio is that it comprises multiple simultaneously sounding sources, such as multiple musical instruments, people talking, machine noises or animal vocalization, the ability to identify and separate individual sources is very desirable. Unfortunately, there are no methods that can solve this problem in a robust fashion. Existing methods of source separation rely sometimes on correlation between different audio channels in multi-channel recordings. The ability to separate sources from stereo signals requires different techniques than those usually applied in communications where multiple sensors are available. Other source separation methods rely on training or clustering of features in mono recording, such as tracking harmonically related partials for multiple pitch detection. Some methods, before explicit recognition, rely on revealing structures in data without knowing the structures (like recognizing objects in abstract pictures without attributing them meaningful labels) by finding the least complex data representations, for instance describing audio scenes as generated by a few tone patterns and their trajectories (polyphonic voices) and acoustical contours drawn by a tone (c
AI-complete
In the field of artificial intelligence (AI), tasks that are hypothesized to require artificial general intelligence to solve are informally known as AI-complete or AI-hard. Calling a problem AI-complete reflects the belief that it cannot be solved by a simple specific algorithm. Prior to 2013, problems supposed to be AI-complete included computer vision, natural language understanding, and dealing with unexpected circumstances while solving any real-world problem. AI-complete tasks were notably considered useful for distinguishing humans from automated agents, as CAPTCHAs aim to do. == History == The term was coined by Fanya Montalvo by analogy with NP-complete and NP-hard in complexity theory, which formally describes the most famous class of difficult problems. Early uses of the term are in Erik Mueller's 1987 PhD dissertation and in Eric Raymond's 1991 Jargon File. Expert systems, that were popular in the 1980s, were able to solve very simple and/or restricted versions of AI-complete problems, but never in their full generality. When AI researchers attempted to "scale up" their systems to handle more complicated, real-world situations, the programs tended to become excessively brittle without commonsense knowledge or a rudimentary understanding of the situation: they would fail as unexpected circumstances outside of its original problem context would begin to appear. When human beings are dealing with new situations in the world, they are helped by their awareness of the general context: they know what the things around them are, why they are there, what they are likely to do and so on. They can recognize unusual situations and adjust accordingly. Expert systems lacked this adaptability and were brittle when facing new situations. DeepMind published a work in May 2022 in which they trained a single model to do several things at the same time. The model, named Gato, can "play Atari, caption images, chat, stack blocks with a real robot arm and much more, deciding based on its context whether to output text, joint torques, button presses, or other tokens." Similarly, some tasks once considered to be AI-complete, like machine translation, are among the capabilities of large language models. == AI-complete problems == AI-complete problems have been hypothesized to include: AI peer review (composite natural language understanding, automated reasoning, automated theorem proving, formalized logic expert system) Bongard problems Computer vision (and subproblems such as object recognition) Natural language understanding (and subproblems such as text mining, machine translation, and word-sense disambiguation) Autonomous driving Dealing with unexpected circumstances while solving any real world problem, whether navigation, planning, or even the kind of reasoning done by expert systems. == Formalization == Computational complexity theory deals with the relative computational difficulty of computable functions. By definition, it does not cover problems whose solution is unknown or has not been characterized formally. Since many AI problems have no formalization yet, conventional complexity theory does not enable a formal definition of AI-completeness. == Research == Roman Yampolskiy suggests that a problem C {\displaystyle C} is AI-Complete if it has two properties: It is in the set of AI problems (Human Oracle-solvable). Any AI problem can be converted into C {\displaystyle C} by some polynomial time algorithm. On the other hand, a problem H {\displaystyle H} is AI-Hard if and only if there is an AI-Complete problem C {\displaystyle C} that is polynomial time Turing-reducible to H {\displaystyle H} . This also gives as a consequence the existence of AI-Easy problems, that are solvable in polynomial time by a deterministic Turing machine with an oracle for some problem. Yampolskiy has also hypothesized that the Turing Test is a defining feature of AI-completeness. Groppe and Jain classify problems which require artificial general intelligence to reach human-level machine performance as AI-complete, while only restricted versions of AI-complete problems can be solved by the current AI systems. For Šekrst, getting a polynomial solution to AI-complete problems would not necessarily be equal to solving the issue of artificial general intelligence, while emphasizing the lack of computational complexity research being the limiting factor towards achieving artificial general intelligence. For Kwee-Bintoro and Velez, solving AI-complete problems would have strong repercussions on society.
DABUS
DABUS (Device for the Autonomous Bootstrapping of Unified Sentience) is an artificial intelligence (AI) system created by Stephen Thaler. It reportedly conceived of two novel products — a food container constructed using fractal geometry, which enables rapid reheating, and a flashing beacon for attracting attention in an emergency. The filing of patent applications designating DABUS as inventor has led to decisions by patent offices and courts on whether a patent can be granted for an invention reportedly made by an AI system. == History in different jurisdictions == === Australia === On 17 September 2019, Thaler filed an application to patent a "Food container and devices and methods for attracting enhanced attention," naming DABUS as the inventor. On 21 September 2020, IP Australia found that section 15(1) of the Patents Act 1990 (Cth) is inconsistent with an artificial intelligence machine being treated as an inventor, and Thaler's application had lapsed. Thaler sought judicial review, and on 30 July 2021, the Federal Court set aside IP Australia's decision and ordered IP Australia to reconsider the application. On 13 April 2022, the Full Court of the Federal Court set aside that decision, holding that only a natural person can be an inventor for the purposes of the Patents Act 1990 (Cth) and the Patents Regulations 1991 (Cth), and that such an inventor must be identified for any person to be entitled to a grant of a patent. On 11 November 2022, Thaler was refused special leave to appeal to the High Court. === European Patent Office === On 17 October 2018 and 7 November 2018, Thaler filed two European patent applications with the European Patent Office. The first claimed invention was a "Food Container" and the second was "Devices and Methods for Attracting Enhanced Attention." On 27 January 2020, the EPO rejected the applications on the grounds that the application listed an AI system named DABUS, and not a human, as the inventor, based on Article 81 and Rule 19(1) of the European Patent Convention (EPC). On 21 December 2021, the Board of Appeal of the EPO dismissed Thaler's appeal from the EPO's primary decision. The Board of Appeal confirmed that "under the EPC the designated inventor has to be a person with legal capacity. This is not merely an assumption on which the EPC was drafted. It is the ordinary meaning of the term inventor." === United Kingdom === Similar applications were filed by Thaler to the United Kingdom Intellectual Property Office on 17 October and 7 November 2018. The Office asked Thaler to file statements of inventorship and of right of grant to a patent (Patent Form 7) in respect of each invention within 16 months of the filing date. Thaler filed those forms naming DABUS as the inventor and explaining in some detail why he believed that machines should be regarded as inventors in the circumstances. His application was rejected on the grounds that: (1) naming a machine as inventor did not meet the requirements of the Patents Act 1977; and (2) the IPO was not satisfied as to the manner in which Thaler had acquired rights that would otherwise vest in the inventor. Thaler was not satisfied with the decision and asked for a hearing before an official known as the "hearing officer". By a decision dated 4 December 2019 the hearing officer rejected Thaler's appeal. Thaler appealed against the hearing officer's decision to the Patents Court (a specialist court within the Chancery Division of the High Court of England and Wales that determines patent disputes). On 21 September 2020, Mr Justice Marcus Smith upheld the decision of the hearing officer. On 21 September 2021, Thaler's further appeal to the Court of Appeal was dismissed by Arnold LJ and Laing LJ (Birss LJ dissenting). On 20 December 2023, the UK Supreme Court dismissed a further appeal by Thaler. In its judgment, the court held that an "inventor" under the Patents Act 1977 must be a natural person. === United States === The patent applications on the inventions were refused by the USPTO, which held that only natural persons can be named as inventors in a patent application. Thaler first fought this result by filing a complaint under the Administrative Procedure Act alleging that the decision was "arbitrary, capricious, an abuse of discretion and not in accordance with the law; unsupported by substantial evidence, and in excess of Defendants’ statutory authority." A month later on August 19, 2019, Thaler filed a petition with the USPTO as allowed in 37 C.F.R. § 1.181 stating that DABUS should be the inventor. The judge and Thaler agreed in this case that Thaler himself is unable to receive the patent on behalf of DABUS. In their August 5, 2022, Thaler decision, the US Court of Appeals for the Federal Circuit affirmed that only a natural person could be an inventor, which means that the AI that invents any other type of invention is not addressed by the "who" mentioned in the legislation. === New Zealand === On January 31, 2022, the Intellectual Property Office of New Zealand (IPONZ) decided that a patent application (776029) filed by Stephen Thaler was void, on the basis that no inventor was identified on the patent application. IPONZ determined that DABUS could not be "an actual devisor of the invention" as required by the Patents Act 2013, and that this must be a natural person as held by the previous patent offices above. The High Court of New Zealand confirmed the decision in 2023. === South Africa === On 24 June 2021, the South African Companies and Intellectual Property Commission (CIPC) accepted Dr Thaler's Patent Cooperation Treaty, for a patent in respect of inventions generated by DABUS. In July 2021, the CIPC released a notice of issuance for the patent. It is the first patent granted for an AI invention. === Switzerland === On June 26, 2025, the Swiss Federal Administrative Court ruled that artificial intelligence systems such as DABUS cannot be listed as inventors in patent applications. The court upheld the existing practice of the Swiss Federal Institute of Intellectual Property (IPI), which requires that only natural persons can be recognized as inventors under Swiss patent law. The case concerned a patent application, which sought to designate DABUS as the sole inventor of a food container designed with a fractal geometry to enhance heat distribution. The IPI had rejected the application, arguing that both the absence of a human inventor and the attribution of inventorship to an AI system were inadmissible. While the court dismissed Thaler's main request, it accepted a subsidiary request: if a human applicant recognizes and files a patent based on an AI-generated invention, that person may be considered the inventor. As a result, the application may proceed with Thaler listed as the inventor. The decision (B-2532/2024) can still be appealed to the Swiss Federal Supreme Court.
Pray.com
Pray.com is a Christian social networking service and mobile application designed to facilitate religious communities. Launched in 2016, it was founded by Steve Gatena, Michael Lynn, Ryan Beck and Matthew Potter. The platform offers features for social networking, daily prayers, sermons, biblical content, and podcasts. The COVID-19 pandemic significantly increased Pray.com's user base, with downloads surging by 955%. During this period, the platform collaborated with churches to support virtual ministry services as in-person gatherings were restricted. The Federal Election Commission issued an opinion in 2021 that allows the platform to feature members of the United States Congress. Pray.com serves as a specialized social media platform for religious groups. Congregations can establish their own groups where members and leaders can participate in discussions, livestream services, and manage donations. Additionally, users can join "prayer communities" to post and respond to prayer requests. For those who subscribe to premium services, the platform provides access to biblically-inspired meditations and bedtime stories, and Bible stories for children. Pray.com also produces Radio drama-style productions with notable actors such as Kristen Bell and Blair Underwood narrating biblical stories. == History == === Funding and development === Pray.com has secured significant funding to support its development and growth. In 2017, the platform raised $2 million in seed funding from Science Inc., Greylock Partners, and Spark Capital. This was followed by a Series A funding round in March 2018, in which the company secured an additional $14 million from TPG Growth, Science Inc., and Greylock Partners. Founder Steve Gatena has highlighted difficulties in securing funding, noting some venture capitalists' negative attitudes towards faith-based technology. === Clinical studies === There have been clinical studies on Pray.com. In one study, the app was found to be acceptable and easy to use among racial and ethnic minority groups, with participants reporting improved mental health and well-being. Greater app use was associated with better outcomes, though low and variable usage suggests the need for further research to fully understand its impact. Another study examined Pray.com's impact on mental health by assigning 192 participants to use the app freely, use its meditative prayer function, or not use it at all. Over two months, participants reported overall improvements in mental health and well-being. Although no significant differences were found between groups, greater app usage correlated with better mental health outcomes. This suggests that religiously based mobile apps may help improve mental health and well-being. Another study of pray.com had similar findings. === National Day of Prayer === Pray first hosted a National Day of Prayer event in 2020 when it streamed to nearly one million viewers on Facebook. In 2021, Pray hosted a virtual event for the National Day of Prayer in the United States. The event featured remarks from public figures including United States President Joe Biden and former Vice President Mike Pence. President Biden spoke of his faith and prayed for an end to the COVID-19 pandemic. Biden remarked: "It means the world to me to know that there are people across the country who include Jill and me in their prayers. And I hope you know that you and your families are in our prayers as well. Today I am praying for the end of this great COVID crisis." The event featured musical performances from Gary Valenciano, Brooke Ligertwood from the Christian band Hillsong Worship, Lecrae, Heather Headley and Michael Neale. Other notable speakers included Ronnie Floyd, Ed Young, Mark Driscoll, and Samuel Rodriguez. Pray.com partnered with Sirius XM, DirecTV and Facebook to stream the event across multiple platforms. Pray.com was featured as a pop-up channel on Sirius XM, channel 154, to host the prayer event and celebrate people of all faith. === Partnerships and sponsorships === In 2024, Pray.com partnered with Sting Ray Robb as the primary sponsor for his No. 41 Chevrolet in the 2024 NTT IndyCar Series. The partnership, highlighting Robb's Christian faith, aims to engage younger audiences with faith-based content. The car, featuring Pray.com's branding, was set to debut at the Firestone Grand Prix of St. Petersburg. A partnership with Palantir Technologies for use of its AI systems was also announced in 2024. === Censorship in China === The app was removed from Apple's App Store in China as part of the country's broader efforts to restrict access to religious content. The app was targeted due to China's stringent regulations on religious material, particularly content distributed through digital platforms. The removal aligns with China's ongoing campaign to control online religious expression and maintain state-approved religious activities.
Biohybrid system
Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.