Non-local means is an algorithm in image processing for image denoising. Unlike "local mean" filters, which take the mean value of a group of pixels surrounding a target pixel to smooth the image, non-local means filtering takes a mean of all pixels in the image, weighted by how similar these pixels are to the target pixel. This results in much greater post-filtering clarity, and less loss of detail in the image compared with local mean algorithms. If compared with other well-known denoising techniques, non-local means adds "method noise" (i.e. error in the denoising process) which looks more like white noise, which is desirable because it is typically less disturbing in the denoised product. Recently non-local means has been extended to other image processing applications such as deinterlacing, view interpolation, and depth maps regularization. == Definition == Suppose Ω {\displaystyle \Omega } is the area of an image, and p {\displaystyle p} and q {\displaystyle q} are two points within the image. Then, the algorithm is: u ( p ) = 1 C ( p ) ∫ Ω v ( q ) f ( p , q ) d q . {\displaystyle u(p)={1 \over C(p)}\int _{\Omega }v(q)f(p,q)\,\mathrm {d} q.} where u ( p ) {\displaystyle u(p)} is the filtered value of the image at point p {\displaystyle p} , v ( q ) {\displaystyle v(q)} is the unfiltered value of the image at point q {\displaystyle q} , f ( p , q ) {\displaystyle f(p,q)} is the weighting function, and the integral is evaluated ∀ q ∈ Ω {\displaystyle \forall q\in \Omega } . C ( p ) {\displaystyle C(p)} is a normalizing factor, given by C ( p ) = ∫ Ω f ( p , q ) d q . {\displaystyle C(p)=\int _{\Omega }f(p,q)\,\mathrm {d} q.} == Common weighting functions == The purpose of the weighting function, f ( p , q ) {\displaystyle f(p,q)} , is to determine how closely related the image at the point p {\displaystyle p} is to the image at the point q {\displaystyle q} . It can take many forms. === Gaussian === The Gaussian weighting function sets up a normal distribution with a mean, μ = B ( p ) {\displaystyle \mu =B(p)} and a variable standard deviation: f ( p , q ) = e − | B ( q ) − B ( p ) | 2 h 2 {\displaystyle f(p,q)=e^{-{{\left\vert B(q)-B(p)\right\vert ^{2}} \over h^{2}}}} where h {\displaystyle h} is the filtering parameter (i.e., standard deviation) and B ( p ) {\displaystyle B(p)} is the local mean value of the image point values surrounding p {\displaystyle p} . == Discrete algorithm == For an image, Ω {\displaystyle \Omega } , with discrete pixels, a discrete algorithm is required. u ( p ) = 1 C ( p ) ∑ q ∈ Ω v ( q ) f ( p , q ) {\displaystyle u(p)={1 \over C(p)}\sum _{q\in \Omega }v(q)f(p,q)} where, once again, v ( q ) {\displaystyle v(q)} is the unfiltered value of the image at point q {\displaystyle q} . C ( p ) {\displaystyle C(p)} is given by: C ( p ) = ∑ q ∈ Ω f ( p , q ) {\displaystyle C(p)=\sum _{q\in \Omega }f(p,q)} Then, for a Gaussian weighting function, f ( p , q ) = e − | B ( q ) 2 − B ( p ) 2 | h 2 {\displaystyle f(p,q)=e^{-{{\left\vert B(q)^{2}-B(p)^{2}\right\vert } \over h^{2}}}} where B ( p ) {\displaystyle B(p)} is given by: B ( p ) = 1 | R ( p ) | ∑ i ∈ R ( p ) v ( i ) {\displaystyle B(p)={1 \over |R(p)|}\sum _{i\in R(p)}v(i)} where R ( p ) ⊆ Ω {\displaystyle R(p)\subseteq \Omega } and is a square region of pixels surrounding p {\displaystyle p} and | R ( p ) | {\displaystyle |R(p)|} is the number of pixels in the region R {\displaystyle R} . == Efficient implementation == The computational complexity of the non-local means algorithm is quadratic in the number of pixels in the image, making it particularly expensive to apply directly. Several techniques were proposed to speed up execution. One simple variant consists of restricting the computation of the mean for each pixel to a search window centred on the pixel itself, instead of the whole image. Another approximation uses summed-area tables and fast Fourier transform to calculate the similarity window between two pixels, speeding up the algorithm by a factor of 50 while preserving comparable quality of the result.
GeneRIF
A GeneRIF or Gene Reference Into Function is a short (255 characters or fewer) statement about the function of a gene. GeneRIFs provide a simple mechanism for allowing scientists to add to the functional annotation of genes described in the Entrez Gene database. In practice, function is constructed quite broadly. For example, there are GeneRIFs that discuss the role of a gene in a disease, GeneRIFs that point the viewer towards a review article about the gene, and GeneRIFs that discuss the structure of a gene. However, the stated intent is for GeneRIFs to be about gene function. Currently over half a million geneRIFs have been created for genes from almost 1000 different species. GeneRIFs are always associated with specific entries in the Entrez Gene database. Each GeneRIF has a pointer to the PubMed ID (a type of document identifier) of a scientific publication that provides evidence for the statement made by the GeneRIF. GeneRIFs are often extracted directly from the document that is identified by the PubMed ID, very frequently from its title or from its final sentence. GeneRIFs are usually produced by NCBI indexers, but anyone may submit a GeneRIF. To be processed, a valid Gene ID must exist for the specific gene, or the Gene staff must have assigned an overall Gene ID to the species. The latter case is implemented via records in Gene with the symbol NEWENTRY. Once the Gene ID is identified, only three types of information are required to complete a submission: a concise phrase describing a function or functions (less than 255 characters in length, preferably more than a restatement of the title of the paper); a published paper describing that function, implemented by supplying the PubMed ID of a citation in PubMed; a valid e-mail address (which will remain confidential). == Example == Here are some GeneRIFs taken from Entrez Gene for GeneID 7157, the human gene TP53. The PubMed document identifiers have been omitted from the examples. Note the wide variability with respect to the presence or absence of punctuation and of sentence-initial capital letters. p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. GeneRIFs are an unusual type of textual genre, and they have recently been the subject of a number of articles from the natural language processing community.
Blocks world
The blocks world is a planning domain in artificial intelligence. It consists of a set of wooden blocks of various shapes and colors sitting on a table. The goal is to build one or more vertical stacks of blocks. Only one block may be moved at a time: it may either be placed on the table or placed atop another block. Because of this, any blocks that are, at a given time, under another block cannot be moved. Moreover, some kinds of blocks cannot have other blocks stacked on top of them. The simplicity of this toy world lends itself readily to classical symbolic artificial intelligence approaches, in which the world is modeled as a set of abstract symbols which may be reasoned about. == Motivation == Artificial Intelligence can be researched in theory and with practical applications. The problem with most practical applications is that the engineers don't know how to program an AI system. Instead of rejecting the challenge at all the idea is to invent an easy to solve domain which is called a toy problem. Toy problems were invented with the aim to program an AI which can solve it. The blocks world domain is an example of a toy problem. Its major advantage over more realistic AI applications is that many algorithms and software programs are available which can handle the situation. This allows comparing different theories against each other. In its basic form, the blocks world problem consists of cubes of the same size which have all the color black. A mechanical robot arm has to pick and place the cubes. More complicated derivatives of the problem consist of cubes of different sizes, shapes and colors. From an algorithmic perspective, blocks world is an NP-hard search and planning problem. The task is to bring the system from an initial state into a goal state. Automated planning and scheduling problems are usually described in the Planning Domain Definition Language (PDDL) notation which is an AI planning language for symbolic manipulation tasks. If something was formulated in the PDDL notation, it is called a domain. Therefore, the task of stacking blocks is a blocks world domain which stands in contrast to other planning problems like the dock worker robot domain and the monkey and banana problem. == Theses/projects which took place in a blocks world == Terry Winograd's SHRDLU Patrick Winston's Learning Structural Descriptions from Examples and Copy Demo Gerald Jay Sussman's Sussman anomaly Decision problem (Gupta and Nau, 1992): Given a starting Blocks World, an ending Blocks World, and an integer L > 0, is there a way to move the blocks to change the starting position to the ending position with L or less steps? This decision problem is NP-hard.
Estimation of distribution algorithm
Estimation of distribution algorithms (EDAs), sometimes called probabilistic model-building genetic algorithms (PMBGAs), are stochastic optimization methods that guide the search for the optimum by building and sampling explicit probabilistic models of promising candidate solutions. Optimization is viewed as a series of incremental updates of a probabilistic model, starting with the model encoding an uninformative prior over admissible solutions and ending with the model that generates only the global optima. EDAs belong to the class of evolutionary algorithms. The main difference between EDAs and most conventional evolutionary algorithms is that evolutionary algorithms generate new candidate solutions using an implicit distribution defined by one or more variation operators, whereas EDAs use an explicit probability distribution encoded by a Bayesian network, a multivariate normal distribution, or another model class. Similarly as other evolutionary algorithms, EDAs can be used to solve optimization problems defined over a number of representations from vectors to LISP style S expressions, and the quality of candidate solutions is often evaluated using one or more objective functions. The general procedure of an EDA is outlined in the following: t := 0 initialize model M(0) to represent uniform distribution over admissible solutions while (termination criteria not met) do P := generate N>0 candidate solutions by sampling M(t) F := evaluate all candidate solutions in P M(t + 1) := adjust_model(P, F, M(t)) t := t + 1 Using explicit probabilistic models in optimization allowed EDAs to feasibly solve optimization problems that were notoriously difficult for most conventional evolutionary algorithms and traditional optimization techniques, such as problems with high levels of epistasis. Nonetheless, the advantage of EDAs is also that these algorithms provide an optimization practitioner with a series of probabilistic models that reveal a lot of information about the problem being solved. This information can in turn be used to design problem-specific neighborhood operators for local search, to bias future runs of EDAs on a similar problem, or to create an efficient computational model of the problem. For example, if the population is represented by bit strings of length 4, the EDA can represent the population of promising solution using a single vector of four probabilities (p1, p2, p3, p4) where each component of p defines the probability of that position being a 1. Using this probability vector it is possible to create an arbitrary number of candidate solutions. == Estimation of distribution algorithms (EDAs) == This section describes the models built by some well known EDAs of different levels of complexity. It is always assumed a population P ( t ) {\displaystyle P(t)} at the generation t {\displaystyle t} , a selection operator S {\displaystyle S} , a model-building operator α {\displaystyle \alpha } and a sampling operator β {\displaystyle \beta } . == Univariate factorizations == The most simple EDAs assume that decision variables are independent, i.e. p ( X 1 , X 2 ) = p ( X 1 ) ⋅ p ( X 2 ) {\displaystyle p(X_{1},X_{2})=p(X_{1})\cdot p(X_{2})} . Therefore, univariate EDAs rely only on univariate statistics and multivariate distributions must be factorized as the product of N {\displaystyle N} univariate probability distributions, D Univariate := p ( X 1 , … , X N ) = ∏ i = 1 N p ( X i ) . {\displaystyle D_{\text{Univariate}}:=p(X_{1},\dots ,X_{N})=\prod _{i=1}^{N}p(X_{i}).} Such factorizations are used in many different EDAs, next we describe some of them. === Univariate marginal distribution algorithm (UMDA) === The UMDA is a simple EDA that uses an operator α U M D A {\displaystyle \alpha _{UMDA}} to estimate marginal probabilities from a selected population S ( P ( t ) ) {\displaystyle S(P(t))} . By assuming S ( P ( t ) ) {\displaystyle S(P(t))} contain λ {\displaystyle \lambda } elements, α U M D A {\displaystyle \alpha _{UMDA}} produces probabilities: p t + 1 ( X i ) = 1 λ ∑ x ∈ S ( P ( t ) ) x i , ∀ i ∈ 1 , 2 , … , N . {\displaystyle p_{t+1}(X_{i})={\dfrac {1}{\lambda }}\sum _{x\in S(P(t))}x_{i},~\forall i\in 1,2,\dots ,N.} Every UMDA step can be described as follows D ( t + 1 ) = α UMDA ∘ S ∘ β λ ( D ( t ) ) . {\displaystyle D(t+1)=\alpha _{\text{UMDA}}\circ S\circ \beta _{\lambda }(D(t)).} === Population-based incremental learning (PBIL) === The PBIL, represents the population implicitly by its model, from which it samples new solutions and updates the model. At each generation, μ {\displaystyle \mu } individuals are sampled and λ ≤ μ {\displaystyle \lambda \leq \mu } are selected. Such individuals are then used to update the model as follows p t + 1 ( X i ) = ( 1 − γ ) p t ( X i ) + ( γ / λ ) ∑ x ∈ S ( P ( t ) ) x i , ∀ i ∈ 1 , 2 , … , N , {\displaystyle p_{t+1}(X_{i})=(1-\gamma )p_{t}(X_{i})+(\gamma /\lambda )\sum _{x\in S(P(t))}x_{i},~\forall i\in 1,2,\dots ,N,} where γ ∈ ( 0 , 1 ] {\displaystyle \gamma \in (0,1]} is a parameter defining the learning rate, a small value determines that the previous model p t ( X i ) {\displaystyle p_{t}(X_{i})} should be only slightly modified by the new solutions sampled. PBIL can be described as D ( t + 1 ) = α PIBIL ∘ S ∘ β μ ( D ( t ) ) {\displaystyle D(t+1)=\alpha _{\text{PIBIL}}\circ S\circ \beta _{\mu }(D(t))} === Compact genetic algorithm (cGA) === The CGA, also relies on the implicit populations defined by univariate distributions. At each generation t {\displaystyle t} , two individuals x , y {\displaystyle x,y} are sampled, P ( t ) = β 2 ( D ( t ) ) {\displaystyle P(t)=\beta _{2}(D(t))} . The population P ( t ) {\displaystyle P(t)} is then sorted in decreasing order of fitness, S Sort ( f ) ( P ( t ) ) {\displaystyle S_{{\text{Sort}}(f)}(P(t))} , with u {\displaystyle u} being the best and v {\displaystyle v} being the worst solution. The CGA estimates univariate probabilities as follows p t + 1 ( X i ) = p t ( X i ) + γ ( u i − v i ) , ∀ i ∈ 1 , 2 , … , N , {\displaystyle p_{t+1}(X_{i})=p_{t}(X_{i})+\gamma (u_{i}-v_{i}),\quad \forall i\in 1,2,\dots ,N,} where, γ ∈ ( 0 , 1 ] {\displaystyle \gamma \in (0,1]} is a constant defining the learning rate, usually set to γ = 1 / N {\displaystyle \gamma =1/N} . The CGA can be defined as D ( t + 1 ) = α CGA ∘ S Sort ( f ) ∘ β 2 ( D ( t ) ) {\displaystyle D(t+1)=\alpha _{\text{CGA}}\circ S_{{\text{Sort}}(f)}\circ \beta _{2}(D(t))} == Bivariate factorizations == Although univariate models can be computed efficiently, in many cases they are not representative enough to provide better performance than GAs. In order to overcome such a drawback, the use of bivariate factorizations was proposed in the EDA community, in which dependencies between pairs of variables could be modeled. A bivariate factorization can be defined as follows, where π i {\displaystyle \pi _{i}} contains a possible variable dependent to X i {\displaystyle X_{i}} , i.e. | π i | = 1 {\displaystyle |\pi _{i}|=1} . D Bivariate := p ( X 1 , … , X N ) = ∏ i = 1 N p ( X i | π i ) . {\displaystyle D_{\text{Bivariate}}:=p(X_{1},\dots ,X_{N})=\prod _{i=1}^{N}p(X_{i}|\pi _{i}).} Bivariate and multivariate distributions are usually represented as probabilistic graphical models (graphs), in which edges denote statistical dependencies (or conditional probabilities) and vertices denote variables. To learn the structure of a PGM from data linkage-learning is employed. === Mutual information maximizing input clustering (MIMIC) === The MIMIC factorizes the joint probability distribution in a chain-like model representing successive dependencies between variables. It finds a permutation of the decision variables, r : i ↦ j {\displaystyle r:i\mapsto j} , such that x r ( 1 ) x r ( 2 ) , … , x r ( N ) {\displaystyle x_{r(1)}x_{r(2)},\dots ,x_{r(N)}} minimizes the Kullback–Leibler divergence in relation to the true probability distribution, i.e. π r ( i + 1 ) = { X r ( i ) } {\displaystyle \pi _{r(i+1)}=\{X_{r(i)}\}} . MIMIC models a distribution p t + 1 ( X 1 , … , X N ) = p t ( X r ( N ) ) ∏ i = 1 N − 1 p t ( X r ( i ) | X r ( i + 1 ) ) . {\displaystyle p_{t+1}(X_{1},\dots ,X_{N})=p_{t}(X_{r(N)})\prod _{i=1}^{N-1}p_{t}(X_{r(i)}|X_{r(i+1)}).} New solutions are sampled from the leftmost to the rightmost variable, the first is generated independently and the others according to conditional probabilities. Since the estimated distribution must be recomputed each generation, MIMIC uses concrete populations in the following way P ( t + 1 ) = β μ ∘ α MIMIC ∘ S ( P ( t ) ) . {\displaystyle P(t+1)=\beta _{\mu }\circ \alpha _{\text{MIMIC}}\circ S(P(t)).} === Bivariate marginal distribution algorithm (BMDA) === The BMDA factorizes the joint probability distribution in bivariate distributions. First, a randomly chosen variable is added as a node in a graph, the most dependent variable to one of those in the graph is chosen among those not yet in the graph, this procedure is repeated until no remain
It's the Most Terrible Time of the Year
It's the Most Terrible Time of the Year is an AI-generated television commercial created for McDonald's Netherlands by TBWA\Neboko and The Sweetshop. It was released on 6 December 2025 before being pulled four days later due to negative reception over its use of generative artificial intelligence and its cynical, negative depiction of the holiday season. == Plot == On a bleak, snowy day, various people in the city experience different kinds of mishaps during the Christmas season. Among other incidents, families struggle with their huge loads of presents; Santa Claus gets stuck in traffic; a Christmas tree "redecorates" a man's home, sending him through the window; another family puts up with annoying relatives and a burnt Christmas dinner. Because of all this chaos, a man decides to find refuge in a McDonald's outlet. A Christmas choir finishes singing the jingle "It's the Most Terrible Time of the Year" with the call to action to "hide out in McDonald's till January's here". == Campaign == It's the Most Terrible Time of the Year is a 45-second television commercial made by Dutch agency TBWA\Neboko with involvement of United States-based film production studio The Sweetshop. The advertisement was produced heavily with generative artificial intelligence (AI) following the trend set by other brands such as Coca-Cola and Toys "R" Us. McDonald's Netherlands, the client, released a statement that the commercial was meant to depict "the stressful moments during the holidays in the Netherlands". The commercial also used Andy Williams's "It's the Most Wonderful Time of the Year" with lyrics changed to fit with the concept of the advertisement. According to The Sweetshop, the production of the advertisement took "seven weeks". It also added that much effort was put into the commercial compared to the traditional process. Ten people of its in-house AI engine The Gardening Club worked on the project. Los Angeles-based directors Mark Potoka and Matt Spicer were initially credited to be involved in the film but they resigned due to being sidelined from the production process. == Reception == The advertisement was released on McDonald's Netherlands' YouTube channel on 6 December 2025. It had a negative reception over the use of generative AI and the "cynical" concept of the work's story. The video was made private on 9 December 2025. The Sweetshop stated that the production of the advertisement took human effort. McDonald's Netherlands, while stating the original intent of the commercial, released a statement after its pullout that, for many of its customers, the holiday season is the "most wonderful time of the year".
Adobe Presenter Video Express
Adobe Presenter Video Express is screencasting and video editing software developed by Adobe Systems. == Description == Adobe Presenter Video Express is primarily used as a software by video creators, to record and mix webcam and screen video feeds. It allows users to simultaneously record video from their webcam and the screen, and easily mix the 2 tracks with a simple user interface. Users can change the background in their recorded video without needing equipment like a green screen. This is unlike other video tools which rely on chroma keying technology, and only work with green or blue screens. They can also add annotations and quizzes to their content and publish the video to MP4 or HTML5 formats. == List of notable features == === Record and mix, screen and webcam === Support for simultaneous recording of screen and webcam video feeds, with a simple editing interface to mix the two video streams. This lets the author rapidly create screencasts, software demos, etc. === Make my background awesome === This feature allows authors to change the background of their webcam recording without needing a green screen, provided they use a solid-colored backdrop which contrasts well against them. Authors can select images, videos or even the screen recording as their background. === In-video quizzing === Authors can insert quizzes within their video content. On success/failure attempts, the author can decide what message to display, and can also configure the video to jump to a certain point and play. Quizzes are published as part of the interactive HTML 5 player, which cannot be hosted on YouTube and Vimeo. === LMS Reporting === Authors can publish to any SCORM compliant LMS (Learning Management System) for quiz reporting, or to Adobe Captivate Prime. === In-app assets and branding === Adobe Presenter Video Express ships with a large number of branding videos, backgrounds and video filters to help authors create studio quality videos. === MP4 and HTML5 Output === The tool publishes a single MP4 video file containing all the video content, within an HTML 5 wrapper that contains the interactive player. The interactive HTML 5 player can be hosted on any website. == Common uses == === Screencasting === Screencasting is the process of recording one's computer screen as a video, usually with an audio voice over, to create a software demonstration, tutorial, presentation, etc. Adobe Presenter Video Express supports simultaneous recording of full screen video and microphone audio for creating screencasts. === Product marketing and demos === The ability to record the webcam video in addition to everything that is visible on the screen in Adobe Presenter Video Express, allows the author to add their personality to their screencasts. Features like video mixing and 'make my background awesome' further enhance the presentation, allowing effortless creation of marketing and demo videos. === Education === Adobe Presenter Video Express supports in-video quizzes and LMS reporting, along with screencasting and webcam recording. These features make it a powerful tool for creating educational content. == Differences from Adobe Presenter and Adobe Captivate == Adobe Presenter is a Microsoft PowerPoint plug-in for converting PowerPoint slides into interactive eLearning content, available only on Windows. Starting with Adobe Presenter 8, the video creation tool Adobe Presenter Video Express was bundled with every purchase of Adobe Presenter. From September 2015, Adobe Presenter Video Express 11 was also made available as a stand-alone product on Windows and Mac. A subscription license for Adobe Presenter Video Express, valid on Windows and Mac, is available for $9.99/month. Adobe Presenter Video Express continues to be bundled with purchases of Adobe Presenter on Windows as well. Adobe Captivate is an authoring tool for creating numerous forms of interactive eLearning content. Unlike Adobe Presenter, it uses a proprietary editing interface instead of Microsoft PowerPoint. While it is possible to create screen captures with Adobe Captivate, you cannot record the webcam feed. Adobe Captivate does not bundle Adobe Presenter or Adobe Presenter Video Express.
Big Mechanism
Big Mechanism is a $45 million DARPA research program, begun in 2014, aimed at developing software that will read cancer research papers, integrate them into a cancer model and frame new hypotheses by the end of 2017 through the automated collection of big data and integrating across various disciplines such as knowledge-based NLP, curation and ontology, systems and mathematical biology by reading research abstracts and papers to extract pieces of causal mechanisms. == Ras gene == The program focuses on mutations in the Ras gene family, which underlie some one-third of human cancers. Currently, a rough road map shows interaction sequences among proteins affecting cell replication and death. However, the causal relations are poorly understood. == Plan == The program is to occur in three stages. The first is to read literature and convert it into formal representations. Second is to integrate the knowledge into computational models. Third is to produce experimentally testable explanations and predictions. Research teams are developing four separate systems targeting all three tasks. In February 2015, an evaluation meeting reviewed progress on the first stage. Multiple tasks were considered. One was extraction of experimental procedure details and evaluating statements such as "we demonstrate" and "we suggest." Another worked to map sentence meaning and relationships. The best machine-reading system extracted 40% of relevant information from a small corpus and correctly determined how each passage related to the model. The second stage is to become active in summer 2015, when members attempt to produce a single reference model. The third stage is the most challenging, because the artificial intelligence community has had limited success at developing hypothesis generators. Molecular biology may be more amenable, because most domain knowledge is technical and available in written form.