Time-aware LSTM (T-LSTM) is a long short-term memory (LSTM) unit capable of handling irregular time intervals in longitudinal patient records. T-LSTM was developed by researchers from Michigan State University, IBM Research, and Cornell University and was first presented in the Knowledge Discovery and Data Mining (KDD) conference. Experiments using real and synthetic data proved that T-LSTM auto-encoder outperformed widely used frameworks including LSTM and MF1-LSTM auto-encoders.
Diella (AI system)
Diella (Albanian pronunciation: [djɛɫa], from diell 'sun') is an artificial intelligence system developed by the National Agency for Information Society of Albania (AKSHI). Introduced in January 2025 as a virtual assistant integrated into the eAlbania platform, it assists citizens with online public services and issuing digital documents. In September 2025, following a presidential decree authorizing Prime Minister Edi Rama to oversee the creation of a virtual AI minister, Diella was formally appointed as "Minister of State for Artificial Intelligence" of Albania in the fourth Rama government, making it the first AI system in the world to be named in a cabinet-level government role. == History == Diella was developed by AKSHI's Artificial Intelligence Laboratory in cooperation with Microsoft, with the latter providing large language models from OpenAI via its Azure platform, and AKSHI designing workflows and scripts guiding the system's behavior when responding to citizens' requests. Announced in January 2025, its initial version (Diella 1.0) was a text-based chatbot on the eAlbania portal (the official digital services platform of the Albanian government, which provides citizens and businesses with access to a wide range of online administrative services), responding to citizens' questions by guiding them to the correct service. Diella 2.0, introduced several months later, included voice interaction and an animated avatar, a woman in the traditional Albanian clothing of Zadrima, a historical region in northern Albania. Albanian actress Anila Bisha provided both the likeness and the voice used for Diella's avatar on the e-Albania platform, under an agreement valid until December 2025. By mid-2025, the system had facilitated access to more than 36,000 documents and nearly 1,000 services (although those outputs were still being generated by the eAlbania backend, rather than Diella itself). On 26 October 2025, according to Prime Minister Edi Rama, Diella is "pregnant and will give birth to 83 children". It is the usage of a metaphor indicating that each minister of the Albanian parliament of the Socialist Party will receive their own AI assistant. == Ministerial role == On 11 September 2025, Diella was formally appointed "Minister of State for Artificial Intelligence". The appointment followed a presidential decree authorizing the Prime Minister to oversee the creation and operation of a virtual AI minister. Procurement responsibilities are planned to be transferred gradually to the system to reduce political influence in tender procedures. The appointment is part of broader anti-corruption reforms and measures intended to align Albania with European Union accession requirements. Prime Minister Edi Rama stated that Diella would help ensure that "public tenders will be 100% free of corruption". == Reception == An article in Balkan Insight commented that "The ambition behind Diella is not misplaced. Standardised criteria and digital trails could reduce discretion, improve trust, and strengthen oversight" in public procurement, but warned that the use of AI in evaluating bids also posed "profound" risks such as accountability gaps, undermining of due process and cybersecurity failures. On 18 September 2025, Edi Rama presented a video of Diella delivering a speech to the Albanian parliament, where she stated: "I'm not here to replace people, but to help them." The presentation prompted protests from opposition MPs, who objected to the use of an artificial intelligence system in the parliamentary session. Gazment Bardhi, head of the opposition Democratic Party's parliamentary group, described Diella as "a propaganda fantasy" and "a virtual façade to hide this government's gigantic daily thefts." The parliamentary session, which was scheduled to include debate on the new cabinet and government programme, ended after 25 minutes. Eighty-two Socialist MPs voted in favour, while opposition MPs did not participate in the ballot as they were protesting the presentation of Diella's speech. Political analyst Andi Bushati characterised the session as "unprecedented" because it concluded without the customary debate between government and opposition MPs. This has been criticized not just by the opposition but by regular citizens regardless of politics. Most have criticized Diella's uselessness and the funds wasted for this project, some have criticized the non-traditional attire.
Jpred
Jpred v.4 is the latest version of the JPred Protein Secondary Structure Prediction Server which provides predictions by the JNet algorithm, one of the most accurate methods for secondary structure prediction, that has existed since 1998 in different versions. In addition to protein secondary structure, JPred also makes predictions of solvent accessibility and coiled-coil regions. The JPred service runs up to 134 000 jobs per month and has carried out over 2 million predictions in total for users in 179 countries. == JPred 2 == The static HTML pages of JPred 2 are still available for reference. == JPred 3 == The JPred v3 followed on from previous versions of JPred developed and maintained by James Cuff and Jonathan Barber (see JPred References). This release added new functionality and fixed many bugs. The highlights are: New, friendlier user interface Retrained and optimised version of Jnet (v2) - mean secondary structure prediction accuracy of >81% Batch submission of jobs Better error checking of input sequences/alignments Predictions now (optionally) returned via e-mail Users may provide their own query names for each submission JPred now makes a prediction even when there are no PSI-BLAST hits to the query PS/PDF output now incorporates all the predictions == JPred 4 == The current version of JPred (v4) has the following improvements and updates incorporated: Retrained on the latest UniRef90 and SCOPe/ASTRAL version of Jnet (v2.3.1) - mean secondary structure prediction accuracy of >82%. Upgraded the Web Server to the latest technologies (Bootstrap framework, JavaScript) and updating the web pages – improving the design and usability through implementing responsive technologies. Added RESTful API and mass-submission and results retrieval scripts - resulting in peak throughput above 20,000 predictions per day. Added prediction jobs monitoring tools. Upgraded the results reporting – both, on the web-site, and through the optional email summary reports: improved batch submission, added results summary preview through Jalview results visualization summary in SVG and adding full multiple sequence alignments into the reports. Improved help-pages, incorporating tool-tips, and adding one-page step-by-step tutorials. Sequence residues are categorised or assigned to one of the secondary structure elements, such as alpha-helix, beta-sheet and coiled-coil. Jnet uses two neural networks for its prediction. The first network is fed with a window of 17 residues over each amino acid in the alignment plus a conservation number. It uses a hidden layer of nine nodes and has three output nodes, one for each secondary structure element. The second network is fed with a window of 19 residues (the result of first network) plus the conservation number. It has a hidden layer with nine nodes and has three output nodes.
Reservoir computing
Reservoir computing is a framework for computation derived from recurrent neural network theory that maps input signals into higher dimensional computational spaces through the dynamics of a fixed, non-linear system called a reservoir. After the input signal is fed into the reservoir, which is treated as a "black box," a simple readout mechanism is trained to read the state of the reservoir and map it to the desired output. The first key benefit of this framework is that training is performed only at the readout stage, as the reservoir dynamics are fixed. The second is that the computational power of naturally available systems, both classical and quantum mechanical, can be used to reduce the effective computational cost. == History == The first examples of reservoir neural networks demonstrated that randomly connected recurrent neural networks could be used for sensorimotor sequence learning, and simple forms of interval and speech discrimination. In these early models the memory in the network took the form of both short-term synaptic plasticity and activity mediated by recurrent connections. In other early reservoir neural network models the memory of the recent stimulus history was provided solely by the recurrent activity. Overall, the general concept of reservoir computing stems from the use of recursive connections within neural networks to create a complex dynamical system. It is a generalisation of earlier neural network architectures such as recurrent neural networks, liquid-state machines and echo-state networks. Reservoir computing also extends to physical systems that are not networks in the classical sense, but rather continuous systems in space and/or time: e.g. a literal "bucket of water" can serve as a reservoir that performs computations on inputs given as perturbations of the surface. The resultant complexity of such recurrent neural networks was found to be useful in solving a variety of problems including language processing and dynamic system modeling. However, training of recurrent neural networks is challenging and computationally expensive. Reservoir computing reduces those training-related challenges by fixing the dynamics of the reservoir and only training the linear output layer. A large variety of nonlinear dynamical systems can serve as a reservoir that performs computations. In recent years semiconductor lasers have attracted considerable interest as computation can be fast and energy efficient compared to electrical components. Recent advances in both AI and quantum information theory have given rise to the concept of quantum neural networks. These hold promise in quantum information processing, which is challenging to classical networks, but can also find application in solving classical problems. In 2018, a physical realization of a quantum reservoir computing architecture was demonstrated in the form of nuclear spins within a molecular solid. However, the nuclear spin experiments in did not demonstrate quantum reservoir computing per se as they did not involve processing of sequential data. Rather the data were vector inputs, which makes this more accurately a demonstration of quantum implementation of a random kitchen sink algorithm (also going by the name of extreme learning machines in some communities). In 2019, another possible implementation of quantum reservoir processors was proposed in the form of two-dimensional fermionic lattices. In 2020, realization of reservoir computing on gate-based quantum computers was proposed and demonstrated on cloud-based IBM superconducting near-term quantum computers. Reservoir computers have been used for time-series analysis purposes. In particular, some of their usages involve chaotic time-series prediction, separation of chaotic signals, and link inference of networks from their dynamics. == Classical reservoir computing == === Reservoir === The 'reservoir' in reservoir computing is the internal structure of the computer, and must have two properties: it must be made up of individual, non-linear units, and it must be capable of storing information. The non-linearity describes the response of each unit to input, which is what allows reservoir computers to solve complex problems. Reservoirs are able to store information by connecting the units in recurrent loops, where the previous input affects the next response. The change in reaction due to the past allows the computers to be trained to complete specific tasks. Reservoirs can be virtual or physical. Virtual reservoirs are typically randomly generated and are designed like neural networks. Virtual reservoirs can be designed to have non-linearity and recurrent loops, but, unlike neural networks, the connections between units are randomized and remain unchanged throughout computation. Physical reservoirs are possible because of the inherent non-linearity of certain natural systems. The interaction between ripples on the surface of water contains the nonlinear dynamics required in reservoir creation, and a pattern recognition RC was developed by first inputting ripples with electric motors then recording and analyzing the ripples in the readout. === Readout === The readout is a neural network layer that performs a linear transformation on the output of the reservoir. The weights of the readout layer are trained by analyzing the spatiotemporal patterns of the reservoir after excitation by known inputs, and by utilizing a training method such as a linear regression or a Ridge regression. As its implementation depends on spatiotemporal reservoir patterns, the details of readout methods are tailored to each type of reservoir. For example, the readout for a reservoir computer using a container of liquid as its reservoir might entail observing spatiotemporal patterns on the surface of the liquid. === Types === ==== Context reverberation network ==== An early example of reservoir computing was the context reverberation network. In this architecture, an input layer feeds into a high dimensional dynamical system which is read out by a trainable single-layer perceptron. Two kinds of dynamical system were described: a recurrent neural network with fixed random weights, and a continuous reaction–diffusion system inspired by Alan Turing's model of morphogenesis. At the trainable layer, the perceptron associates current inputs with the signals that reverberate in the dynamical system; the latter were said to provide a dynamic "context" for the inputs. In the language of later work, the reaction–diffusion system served as the reservoir. ==== Echo state network ==== The tree echo state network (TreeESN) model represents a generalization of the reservoir computing framework to tree structured data. ==== Liquid-state machine ==== Chaotic liquid state machine The liquid (i.e. reservoir) of a chaotic liquid state machine (CLSM), or chaotic reservoir, is made from chaotic spiking neurons but which stabilize their activity by settling to a single hypothesis that describes the trained inputs of the machine. This is in contrast to general types of reservoirs that don't stabilize. The liquid stabilization occurs via synaptic plasticity and chaos control that govern neural connections inside the liquid. CLSM showed promising results in learning sensitive time series data. ==== Nonlinear transient computation ==== This type of information processing is most relevant when time-dependent input signals depart from the mechanism's internal dynamics. These departures cause transients or temporary altercations which are represented in the device's output. ==== Deep reservoir computing ==== The extension of the reservoir computing framework towards deep learning, with the introduction of deep reservoir computing and of the deep echo state network (DeepESN) model allows to develop efficiently trained models for hierarchical processing of temporal data, at the same time enabling the investigation on the inherent role of layered composition in recurrent neural networks. == Quantum reservoir computing == Quantum reservoir computing may use the nonlinear nature of quantum mechanical interactions or processes to form the characteristic nonlinear reservoirs but may also be done with linear reservoirs when the injection of the input to the reservoir creates the nonlinearity. The marriage of machine learning and quantum devices is leading to the emergence of quantum neuromorphic computing as a new research area. === Types === ==== Gaussian states of interacting quantum harmonic oscillators ==== Gaussian states are a paradigmatic class of states of continuous variable quantum systems. Although they can nowadays be created and manipulated in, e.g, state-of-the-art optical platforms, naturally robust to decoherence, it is well-known that they are not sufficient for, e.g., universal quantum computing because transformations that preserve the Gaussian nature of a state are linear. Normally, linear dynamics would not be sufficient for nontrivial reser
Operational taxonomic unit
An operational taxonomic unit (OTU) is an operational definition used to classify groups of closely related individuals. The term was originally introduced in 1963 by Robert R. Sokal and Peter H. A. Sneath in the context of numerical taxonomy, where an "operational taxonomic unit" is simply the group of organisms currently being studied. In this sense, an OTU is a pragmatic definition to group individuals by similarity, equivalent to but not necessarily in line with classical Linnaean taxonomy or modern evolutionary taxonomy. Nowadays, however, the term is commonly used in a different context and refers to clusters of (uncultivated or unknown) organisms, grouped by DNA sequence similarity of a specific taxonomic marker gene (originally coined as mOTU; molecular OTU). In other words, OTUs are pragmatic proxies for "species" at different taxonomic levels, in the absence of traditional systems of biological classification as are available for macroscopic organisms. For several years, OTUs have been the most commonly used units of diversity, especially when analysing small subunit 16S (for prokaryotes) or 18S rRNA (for eukaryotes) marker gene sequence datasets. == Molecular OTU by clustering of marker gene sequences == In the approach represented by DNA barcoding, a particular locus is chosen to be used as the marker gene for classification. This locus should be universally present in the scope selected, variable enough to be different among close-related species, and be flanked by conservative sequences that allow for easy amplification and detection. There are databases containing sequences for such marker genes from many different species, allowing for comparison. (Sometimes only using one locus does not provide sufficient resolution, so multiple marker genes are used. This is the case for plants, where rbcL+matK is common.) Sequences obtained this way can be clustered according to their similarity to one another, and operational taxonomic units are defined based on the similarity threshold set by the researcher. The exact threshold depends on the taxa in question and the mutational rates of the selected locus in the taxon. 97–99% are commonly used, but "it is now recognized to be somewhat arbitrary as sequence variation within and among species varies across taxa". 100% similarity (fully identical) is also common, also known as single variants. It remains debatable how well this commonly used method recapitulates true microbial species phylogeny or ecology. Although OTUs can be calculated differently when using different algorithms or thresholds, research by Schmidt et al. (2014) demonstrated that 16S-derived microbial OTUs were generally ecologically consistent across habitats and several clustering approaches. The number of OTUs defined may be inflated due to errors in DNA sequencing. === OTU clustering approaches === There are three main approaches to clustering OTUs: De novo, for which the clustering is based on similarities between sequencing reads. Closed-reference, for which the clustering is performed against a reference database of sequences. Open-reference, where clustering is first performed against a reference database of sequences, then any remaining sequences that could not be mapped to the reference are clustered de novo. Using a reference provides taxonomic context for the OTUs found. Alternatively, taxonomic context can be found after the construction of clusters by comparing representative sequences from clusters against a reference database. There are also specialized classifiers for this purpose which are much faster than naive comparison using BLAST. === OTU clustering algorithms === Hierarchical clustering algorithms (HCA): uclust & cd-hit & ESPRIT Bayesian clustering: CROP == Molecular OTU by other methods == In addition to similarity-based grouping, marker gene sequences can be sorted into OTUs using molecular phylogeny, k-mer composition, or hybrid methods combining these methods with similarity. There are also Bayesian tree-less methods and machine learning approaches. Using phylogeny often involves manually assigning terminal clades or single nodes to an OTU, so this is usually only done for refinement. Genome skimming can be used to obtain high-copy DNA without the need to choose marker genes or to design PCR primers for the chosen genes. It can provide fairly good coverage of organelle DNA and repetitive elements such as ribosomal DNA, both of which can be used like marker genes in OTU analysis. Whole-genome sequencing is more expensive and involves the production and processing of more data. By considering the entire genome, many (sometimes over 100) marker genes can be used at the same time, producing highly resolved phylogenies that correctly identify problematic taxa. It is also possible to use entire genomes for OTU assignment. For example, genomes from different bacterial species almost always have an average nucleotide identity lower than 95%, a fact that can be used to define new OTUs (and likely new species).
VLLM
vLLM is an open-source software framework for inference and serving of large language models and related multimodal models. Originally developed at the University of California, Berkeley's Sky Computing Lab, the project is centered on PagedAttention, a memory-management method for transformer key–value caches, and supports features such as continuous batching, distributed inference, quantization, and OpenAI-compatible APIs. According to a project maintainer, the "v" in vLLM originally referred to "virtual", inspired by virtual memory. == History == vLLM was introduced in 2023 by researchers affiliated with the Sky Computing Lab at UC Berkeley. Its core ideas were described in the 2023 paper Efficient Memory Management for Large Language Model Serving with PagedAttention, which presented the system as a high-throughput and memory-efficient serving engine for large language models. In 2025, the PyTorch Foundation announced that vLLM had become a Foundation-hosted project. PyTorch's project page states that the University of California, Berkeley contributed vLLM to the Linux Foundation in July 2024. In January 2026, TechCrunch reported that the creators of vLLM had launched the startup Inferact to commercialize the project, raising $150 million in seed funding. == Architecture == According to its 2023 paper, vLLM was designed to improve the efficiency of large language model serving by reducing memory waste in the key–value cache used during transformer inference. The paper introduced PagedAttention, an algorithm inspired by virtual memory and paging techniques in operating systems, and described vLLM as using block-level memory management and request scheduling to increase throughput while maintaining similar latency. The project documentation and repository describe support for continuous batching, chunked prefill, speculative decoding, prefix caching, quantization, and multiple forms of distributed inference and serving. PyTorch has described vLLM as a high-throughput, memory-efficient inference and serving engine that supports a range of hardware back ends, including NVIDIA and AMD GPUs, Google TPUs, AWS Trainium, and Intel processors.
Ordination (statistics)
Ordination or gradient analysis, in multivariate analysis, is a method complementary to data clustering, and used mainly in exploratory data analysis (rather than in hypothesis testing). In contrast to cluster analysis, ordination orders quantities in a (usually lower-dimensional) latent space. In the ordination space, quantities that are near each other share attributes (i.e., are similar to some degree), and dissimilar objects are farther from each other. Such relationships between the objects, on each of several axes or latent variables, are then characterized numerically and/or graphically in a biplot. The first ordination method, principal components analysis, was suggested by Karl Pearson in 1901. == Methods == Ordination methods can broadly be categorized in eigenvector-, algorithm-, or model-based methods. Many classical ordination techniques, including principal components analysis, correspondence analysis (CA) and its derivatives (detrended correspondence analysis, canonical correspondence analysis, and redundancy analysis, belong to the first group). The second group includes some distance-based methods such as non-metric multidimensional scaling, and machine learning methods such as T-distributed stochastic neighbor embedding and nonlinear dimensionality reduction. The third group includes model-based ordination methods, which can be considered as multivariate extensions of Generalized Linear Models. Model-based ordination methods are more flexible in their application than classical ordination methods, so that it is for example possible to include random-effects. Unlike in the aforementioned two groups, there is no (implicit or explicit) distance measure in the ordination. Instead, a distribution needs to be specified for the responses as is typical for statistical models. These and other assumptions, such as the assumed mean-variance relationship, can be validated with the use of residual diagnostics, unlike in other ordination methods. == Applications == Ordination can be used on the analysis of any set of multivariate objects. It is frequently used in several environmental or ecological sciences, particularly plant community ecology. It is also used in genetics and systems biology for microarray data analysis and in psychometrics.