AI Essay Stock Market

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  • Lessac Technologies

    Lessac Technologies

    Lessac Technologies, Inc. (LTI) is an American firm which develops voice synthesis software, licenses technology and sells synthesized novels as MP3 files. The firm currently has seven patents granted and three more pending for its automated methods of converting digital text into human-sounding speech, more accurately recognizing human speech and outputting the text representing the words and phrases of said speech, along with recognizing the speaker's emotional state. The LTI technology is partly based on the work of the late Arthur Lessac, a Professor of Theater at the State University of New York and the creator of Lessac Kinesensic Training, and LTI has licensed exclusive rights to exploit Arthur Lessac's copyrighted works in the fields of speech synthesis and speech recognition. Based on the view that music is speech and speech is music, Lessac's work and books focused on body and speech energies and how they go together. Arthur Lessac's textual annotation system, which was originally developed to assist actors, singers, and orators in marking up scripts to prepare for performance, is adapted in LTI's speech synthesis system as the basic representation of the speech to be synthesized (Lessemes), in contrast to many other systems which use a phonetic representation. LTI's software has two major components: (1) a linguistic front-end that converts plain text to a sequence of prosodic and phonosensory graphic symbols (Lessemes) based on Arthur Lessac's annotation system, which specify the speech units to be synthesized; (2) a signal-processing back-end that takes the Lessemes as acoustic data and produces human-sounding synthesized speech as output, using unit selection and concatenation. LTI's text-to-speech system came in second in the world-wide Blizzard Challenge 2011 and 2012. The first-place team in 2011 also employed LTI's "front-end" technology, but with its own back-end. The Blizzard Challenge, conducted by the Language Technologies Institute of Carnegie Mellon University, was devised as a way to evaluate speech synthesis techniques by having different research groups build voices from the same voice-actor recordings, and comparing the results through listening tests. LTI was founded in 2000 by H. Donald Wilson (chairman), a lawyer, LexisNexis entrepreneur and business associate of Arthur Lessac; and Gary A. Marple (chief inventor), after Marple suggested that Arthur Lessac's kinesensic voice training might be applicable to computational linguistics. After Wilson's death in 2006, his nephew John Reichenbach became the firm's CEO.

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  • Magnetic ink character recognition

    Magnetic ink character recognition

    Magnetic ink character recognition code, known in short as MICR code, is a character recognition technology used mainly by the banking industry to streamline the processing and clearance of cheques and other documents. MICR encoding, called the MICR line, is at the bottom of cheques and other vouchers and typically includes the document-type indicator, bank code, bank account number, cheque number, cheque amount (usually added after a cheque is presented for payment), and a control indicator. The format for the bank code and bank account number is country-specific. The technology allows MICR readers to scan and read the information directly into a data-collection device. Unlike barcode and similar technologies, MICR characters can be read easily by humans. MICR encoded documents can be processed much faster and more accurately than conventional OCR encoded documents. == Pre-Unicode standard representation == The ISO standard ISO 2033:1983, and the corresponding Japanese Industrial Standard JIS X 9010:1984 (originally JIS C 6229–1984), define character encodings for OCR-A, OCR-B and E-13B. == International spread == There are two major MICR fonts in use: E-13B and CMC-7. There is no particular international agreement on which countries use which font. In practice, this does not create particular problems as cheques and other vouchers do not usually flow out of a particular jurisdiction. The E-13B font has been adopted as an international standard in ISO 1004-1:2013, and is the standard in Australia, Canada, the United Kingdom, the United States, as well as Central America and much of Asia, besides other countries. The CMC-7 font has been adopted as an international standard in ISO 1004-2:2013, and is widely used in Europe, including France and Italy, Mexico, and South America, including Argentina, Brazil, Chile, besides other countries. Israel is the only country that can use both fonts simultaneously, though the practice makes the system significantly less efficient. This situation is the product of the Israelis adopting CMC-7, while the Palestinians opted for E-13B. == Fonts == === E-13B === E-13B is a 14-character set, comprising the 10 decimal digits, and the following symbols: ⑆ (transit: used to delimit a bank code); ⑈ (on-us: used to delimit a customer account number); ⑇ (amount: used to delimit a transaction amount); ⑉ (dash: used to delimit parts of numbers—e.g., routing numbers or account numbers). In the check printing and banking industries the E-13B MICR line is also commonly referred to as the TOAD line. This reference comes from the 4 characters: Transit, On-us, Amount, and Dash. Compared to CMC-7, some pairs of E-13B characters (notably 2 and 5) can produce relatively similar results when magnetically scanned; however, as a fallback if magnetic reading fails, E-13B also performs well under optical character recognition. The E-13B repertoire can be represented in Unicode (see below). The official Unicode names contain misnomers. For example, the ⑈ on-us symbol is official titled "OCR Dash". Prior to Unicode, it could be encoded according to ISO 2033:1983, which encodes digits in their usual ASCII locations, transit as 0x3A, on-us as 0x3C, amount as 0x3B, and dash as 0x3D. For EBCDIC, IBM code page 1001 encodes digits in their usual EBCDIC locations, transit as 0xDB, on-us as 0xEB, amount as 0xCB, and dash as 0xFB. IBM code page 1032 extends code page 1001 by adding alternative encodings for transit at 0x5C, 0x7A and 0xC1, on-us at 0x4C, 0x61 and 0xC3, amount at 0x5B, 0x5E and 0xC2 and dash at 0x60, 0x7E and 0xC4, in addition to a zero-width space at 0x5A. These alternative representations were added for interoperability with Siemens and Océ printers. === CMC-7 === CMC-7 includes 10 numeric digits, 26 capital letters, and 5 control characters: S I (internal), S II (terminator), S III (amount), S IV (an unused character), and S V (routing). CMC-7 has a barcode format, with every character having two distinct large gaps in different places, as well as distinct patterns in between, to minimize any chance for character confusion while reading magnetically; however, these bars are too close and narrow to be reliably recognised at a typical scan resolution if falling back to optical scanning. CMC-7 can also produce superficially successful, but incorrect, scans of upside-down MICR lines. Unicode does not include support for the CMC-7 control symbols. IBM code page 1033 encodes: Digits and capitals in their usual EBCDIC locations S I (internal) as 0x5E, 0x61 or 0xCB; S II (terminator) as 0x4C, 0x5B or 0xEB; S III (amount) as 0x60, 0x7E or 0xFB; S IV as 0x50, 0x7A or 0xDB; S V (routing) as 0x5C, 0x6E or 0xBB. == MICR reader == MICR characters are printed on documents in one of the two MICR fonts, using magnetizable (commonly known as magnetic) ink or toner, usually containing iron oxide. In scanning, the document is passed through a MICR reader, which performs two functions: magnetization of the ink, and detection of the characters. The characters are read by a MICR reader head, a device similar to the playback head of a tape recorder. As each character passes over the head, it produces a unique waveform that can be easily identified by the system. MICR readers are the primary tool for cheque sorting and are used across the cheque distribution network at multiple stages. For example, a merchant will use a MICR reader to sort cheques by bank and send the sorted cheques to a clearing house for redistribution to those banks. Upon receipt, the banks perform another MICR sort to determine which customer's account is charged and to which branch the cheque should be sent on its way back to the customer. However, many banks no longer offer this last step of returning the cheque to the customer. Instead, cheques are scanned and stored digitally. Sorting of cheques is done as per the geographical coverage of banks in a nation. == Unicode == OCR and MICR characters have been included in the Unicode Standard since at least version 1.1 (June 1993). Since the Unicode Character Database only tracks characters starting with version 1.1, they may also have been present in Unicode 1.0 or 1.0.1. The Unicode block that includes OCR and MICR characters is called Optical Character Recognition and covers U+2440–U+245F. Of the characters in this block, four are from the MICR E-13B font: U+2446 ⑆ OCR BRANCH BANK IDENTIFICATION U+2447 ⑇ OCR AMOUNT OF CHECK U+2448 ⑈ OCR DASH (corrected alias MICR ON US SYMBOL) U+2449 ⑉ OCR CUSTOMER ACCOUNT NUMBER (corrected alias MICR DASH SYMBOL) The names of the latter two characters were inadvertently switched when they were named in ISO/IEC 10646:1993, and they have been assigned accurate names as formal aliases. Per the Unicode Stability Policy, the existing names remain, allowing their use as stable identifiers. Additionally, all four characters have informative (non-formal) aliases in the Unicode charts: "transit", "amount", "on-us", and "dash" respectively. Prior to Unicode, these symbols had been encoded by the ISO-IR-98 encoding defined by ISO 2033:1983, in which they were simply named SYMBOL ONE through SYMBOL FOUR. They were encoded immediately following the digits, which were encoded at their ASCII locations. Although ISO 2033 also specifies encoding for OCR-A and OCR-B, its encoding for E-13B is known simply as ISO_2033-1983 by the IANA. == History == Before the mid-1940s, cheques were processed manually using the Sort-A-Matic or Top Tab Key method. The processing and cheque clearing was very time-consuming and was a significant cost in cheque clearance and bank operations. As the number of cheques increased, ways were sought for automating the process. Standards were developed to ensure uniformity in financial institutions. By the mid-1950s, the Stanford Research Institute and General Electric Computer Laboratory had developed the first automated system to process cheques using MICR. The same team also developed the E-13B MICR font. "E" refers to the font being the fifth considered, and "B" to the fact that it was the second version. The "13" refers to the 0.013-inch character grid. The trial of MICR E-13B font was shown to the American Bankers Association (ABA) in July 1956, which adopted it in 1958 as the MICR standard for negotiable documents in the United States. ABA adopted MICR as its standard because machines could read MICR accurately, and MICR could be printed using existing technology. In addition, MICR remained machine readable, even through overstamping, marking, mutilation and more. The first cheques using MICR were printed by the end of 1959. Although compliance with MICR standards was voluntary in the United States, it had been almost universally adopted in the United States by 1963. In 1963, ANSI adopted the ABA's E-13B font as the American standard for MICR printing, and E-13B was also standardized as ISO 1004:1995. Other countries set their own standards, though the MICR readers and m

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  • Markov property

    Markov property

    In probability theory and statistics, the Markov property is the memoryless property of a stochastic process, which means that its future evolution is independent of its history. It is named after the Russian mathematician Andrey Markov. The term strong Markov property is similar to the Markov property, except that the meaning of "present" is defined in terms of a random variable known as a stopping time. The term Markov assumption is used to describe a model where the Markov property is assumed to hold, such as a hidden Markov model. A Markov random field extends this property to two or more dimensions or to random variables defined for an interconnected network of items. An example of a model for such a field is the Ising model. A discrete-time stochastic process satisfying the Markov property is known as a Markov chain. == Introduction == A stochastic process has the Markov property if the conditional probability distribution of future states of the process (conditional on both past and present values) depends only upon the present state; that is, given the present, the future does not depend on the past. A process with this property is said to be Markov or Markovian and known as a Markov process. Two famous classes of Markov process are the Markov chain and Brownian motion. Note that there is a subtle, often overlooked and very important point that is often missed in the plain English statement of the definition: the statespace of the process is constant through time. The conditional description involves a fixed "bandwidth". For example, without this restriction we could augment any process to one which includes the complete history from a given initial condition and it would be made to be Markovian. But the state space would be of increasing dimensionality over time and does not meet the definition. == History == == Definition == Let ( Ω , F , P ) {\displaystyle (\Omega ,{\mathcal {F}},P)} be a probability space with a filtration ( F s , s ∈ I ) {\displaystyle ({\mathcal {F}}_{s},\ s\in I)} , for some (totally ordered) index set I {\displaystyle I} ; and let ( S , Σ ) {\displaystyle (S,\Sigma )} be a measurable space. An ( S , Σ ) {\displaystyle (S,\Sigma )} -valued stochastic process X = { X t : Ω → S } t ∈ I {\displaystyle X=\{X_{t}:\Omega \to S\}_{t\in I}} adapted to the filtration is said to possess the Markov property if, for each A ∈ Σ {\displaystyle A\in \Sigma } and each s , t ∈ I {\displaystyle s,t\in I} with s < t {\displaystyle s Read more →

  • Android Auto

    Android Auto

    Android Auto is a mobile app developed by Google to mirror features of a smartphone (or other Android device) on a car's dashboard information and entertainment head unit. Once an Android device is paired with the car's head unit, the system can mirror some apps on the vehicle's display. Supported apps include GPS mapping and navigation, music playback, SMS, telephone, and Web search. The system supports both touchscreen and button-controlled head units. Hands-free operation through voice commands is available and recommended to reduce driver distraction. Android Auto is part of the Open Automotive Alliance, a joint effort of 28 automobile manufacturers, with Nvidia as tech supplier, available in 36 countries. == History == Android Auto was revealed at Google I/O 2014. The app was released to the public on March 19, 2015. In November 2016, Google implemented an app that would run the Android Auto UI on the mobile device. In July 2019, Android Auto received its first major UI rework, which among other changes, brought an app drawer to Android Auto for the first time. Google also announced that the app's ability to be used on a phone would be discontinued in favor of Google Assistant's drive mode. In December 2020, Google announced the expansion of Android Auto to 36 additional countries in Europe, Indonesia, and more. In April 2021, Android Auto launched in Belgium, Denmark, Netherlands, Norway, Portugal, and Sweden. Google announced in May 2022 a user interface redesign for Android Auto, codenamed CoolWalk, which aims to simplify the app's usage, and make it more adaptable to screens of different orientations and aspect ratios. The redesign incorporates a new split-screen layout, where Google Maps can be displayed alongside a music player. CoolWalk was originally slated to launch in Q3 2022. In June 2022, Android Auto no longer ran directly on a mobile device; the app permitting this was decommissioned, in favor of a Driving Mode built into the Google Assistant app for a similar purpose. In November 2022, the CoolWalk user interface was released in Android Auto's beta program. == Functionality == Android Auto is software that can be utilized from an Android mobile device, acting as a vehicle's dashboard head unit. Once the user's Android device is connected to the vehicle, the head unit will serve as an external display for the Android device, presenting supported software in a car-specific user interface provided by the Android Auto app. In Android Auto's first iterations, the device was required to be connected via USB to the car. For some time, starting in November 2016, Google added the option to run Android Auto as a regular app on an Android device, allowing users to choose whether to use Android Auto on a personal phone or tablet, rather than on a compatible automotive head unit. This app was decommissioned in June 2022 in favor of a Driving Mode built into the Google Assistant app. At CES 2018, Google confirmed that the Google Assistant would be coming to Android Auto later in the year. An Android Auto SDK has been released, allowing third parties to modify their apps to work with Android Auto; initially, only APIs for music and messaging apps were available. == Head unit support == In May 2015, Hyundai became the first manufacturer to offer Android Auto support, making it first available in the 2015 Hyundai Sonata. Automobile manufacturers that will offer Android Auto support in their cars include Abarth, Acura, Alfa Romeo, Aston Martin, Audi, Bentley, Buick, BMW, BYD, Cadillac, Chevrolet, Chrysler, Citroën, Dodge, Ferrari, Fiat, Ford, GMC, Genesis, Holden, Honda, Hyundai, Infiniti, Jaguar Land Rover, Jeep, Kia, Lamborghini, Lexus, Lincoln, Mahindra and Mahindra, Maserati, Maybach, Mazda, Mercedes-Benz, Mitsubishi, Nissan, Opel, Peugeot, Porsche, RAM, Renault, SEAT, Škoda, SsangYong, Subaru, Suzuki, Tata Motors Cars, Toyota, Volkswagen and Volvo. Additionally, aftermarket car-audio systems supporting Android Auto add the technology into host vehicles, including Pioneer, Kenwood, Panasonic, and Sony. == Criticism == In May 2019, Italy filed an antitrust complaint targeting Android Auto, citing a Google policy of allowing third-parties to only offer media and messaging apps on the platform, preventing Enel from offering an app for locating vehicle charging stations. Google announced a new SDK, to be released to select partners in August 2020 and made generally available by the end of the year. == Availability == As of December 2025, Android Auto is available in 46 countries:

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  • Teamwork (project management)

    Teamwork (project management)

    Teamwork.com is an Irish, privately owned, web-based software company headquartered in Cork, Ireland. Teamwork creates task management and team collaboration software. Founded in 2007, as of 2016 the company stated that its software was in use by over 370,000 organisations worldwide (including Disney, Spotify and HP), and that it had over 2.4m users. == History == Peter Coppinger and Dan Mackey founded a company, Digital Crew, in 2007. This company built websites, intranets and custom web-based solutions for clients in Cork, Ireland. Frustrated by whiteboards and software management tools, Coppinger wanted a software system that would help manage client projects and which would be easy to use and generic enough to be used by different types of companies. Originally 37signals Basecamp users themselves, Coppinger and Mackey were frustrated by the limited feature set, and by Basecamp's apparent inaction on their feedback. In October 2007, Coppinger and Mackey launched Teamwork Project Manager, nicknamed TeamworkPM. In March 2015, this was renamed as Teamwork Projects. In 2014, after two years of negotiations, TeamworkPM bought the domain name 'Teamwork.com' for US$675,000 (€500,000). At the time this was one of the most expensive domain name purchases by an Irish company, and involved the transfer of a domain name which had been dormant since it was first acquired by the original owner in 1999. In 2015, Teamwork.com was named by Gartner to be one of their "Cool Vendors" in the Program and Portfolio Management Category. This was followed by the launch of a new real-time messaging product, Teamwork Chat, in January 2015. In June 2015, the company announced a drive to recruit for 40 positions by the end of the year. This was followed by the announcement that the company was investing more than €1 million in a new office, and had leased office space in Park House, Blackpool. In June 2016, Teamwork.com undertook a further recruitment drive to entice developers to Cork. In July 2021, the company announced that it had raised an investment of $70 million (€59.1 million) from venture capital firm Bregal Milestone to fund further growth. == Products == Teamwork markets a number of cloud-based applications, including Teamwork, Teamwork Desk, Teamwork Spaces, Teamwork CRM and Teamwork Chat. Teamwork was launched on 4 October 2007, at which time it had time management, milestone management, file sharing, time tracking, and messaging features. Teamwork's platform reportedly integrates with martech software like HubSpot, as well as other productivity tools like Slack, G Suite, MS Teams, Zapier, Dropbox and QuickBooks. == Awards == In 2016, Teamwork was awarded Cork's Best SME in the Cork Chamber of Commerce "Company of the Year" awards. In 2016, Teamwork was named number 7 in Deloitte's Fast 50 tech companies hit €1.6bn turnover. In 2015, Teamwork was identified as a Gartner "Cool Vendor" in the Program and Portfolio Management Category.

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  • GLIMMER

    GLIMMER

    In bioinformatics, GLIMMER (Gene Locator and Interpolated Markov ModelER) is used to find genes in prokaryotic DNA. "It is effective at finding genes in bacteria, archea, viruses, typically finding 98-99% of all relatively long protein coding genes". GLIMMER was the first system that used the interpolated Markov model to identify coding regions. The GLIMMER software is open source and is maintained by Steven Salzberg, Art Delcher, and their colleagues at the Center for Computational Biology at Johns Hopkins University. The original GLIMMER algorithms and software were designed by Art Delcher, Simon Kasif and Steven Salzberg and applied to bacterial genome annotation in collaboration with Owen White. == Versions == === GLIMMER 1.0 === First Version of GLIMMER "i.e., GLIMMER 1.0" was released in 1998 and it was published in the paper Microbial gene identification using interpolated Markov model. Markov models were used to identify microbial genes in GLIMMER 1.0. GLIMMER considers the local composition sequence dependencies which makes GLIMMER more flexible and more powerful when compared to fixed-order Markov model. There was a comparison made between interpolated Markov model used by GLIMMER and fifth order Markov model in the paper Microbial gene identification using interpolated Markov models. "GLIMMER algorithm found 1680 genes out of 1717 annotated genes in Haemophilus influenzae where fifth order Markov model found 1574 genes. GLIMMER found 209 additional genes which were not included in 1717 annotated genes where fifth order Markov model found 104 genes."' === GLIMMER 2.0 === Second Version of GLIMMER i.e., GLIMMER 2.0 was released in 1999 and it was published in the paper Improved microbial identification with GLIMMER. This paper provides significant technical improvements such as using interpolated context model instead of interpolated Markov model and resolving overlapping genes which improves the accuracy of GLIMMER. Interpolated context models are used instead of interpolated Markov model which gives the flexibility to select any base. In interpolated Markov model probability distribution of a base is determined from the immediate preceding bases. If the immediate preceding base is irrelevant amino acid translation, interpolated Markov model still considers the preceding base to determine the probability of given base where as interpolated context model which was used in GLIMMER 2.0 can ignore irrelevant bases. False positive predictions were increased in GLIMMER 2.0 to reduce the number of false negative predictions. Overlapped genes are also resolved in GLIMMER 2.0. Various comparisons between GLIMMER 1.0 and GLIMMER 2.0 were made in the paper Improved microbial identification with GLIMMER which shows improvement in the later version. "Sensitivity of GLIMMER 1.0 ranges from 98.4 to 99.7% with an average of 99.1% where as GLIMMER 2.0 has a sensitivity range from 98.6 to 99.8% with an average of 99.3%. GLIMMER 2.0 is very effective in finding genes of high density. The parasite Trypanosoma brucei, responsible for causing African sleeping sickness is being identified by GLIMMER 2.0" === GLIMMER 3.0 === Third version of GLIMMER, "GLIMMER 3.0" was released in 2007 and it was published in the paper Identifying bacterial genes and endosymbiont DNA with Glimmer. This paper describes several major changes made to the GLIMMER system including improved methods to identify coding regions and start codon. Scoring of ORF in GLIMMER 3.0 is done in reverse order i.e., starting from stop codon and moves back towards the start codon. Reverse scanning helps in identifying the coding portion of the gene more accurately which is contained in the context window of IMM. GLIMMER 3.0 also improves the generated training set data by comparing the long-ORF with universal amino acid distribution of widely disparate bacterial genomes."GLIMMER 3.0 has an average long-ORF output of 57% for various organisms where as GLIMMER 2.0 has an average long-ORF output of 39%." GLIMMER 3.0 reduces the rate of false positive predictions which were increased in GLIMMER 2.0 to reduce the number of false negative predictions. "GLIMMER 3.0 has a start-site prediction accuracy of 99.5% for 3'5' matches where as GLIMMER 2.0 has 99.1% for 3'5' matches. GLIMMER 3.0 uses a new algorithm for scanning coding regions, a new start site detection module, and architecture which integrates all gene predictions across an entire genome." Minimum description length === Theoretical and Biological Foundation === The GLIMMER project helped introduce and popularize the use of variable length models in Computational Biology and Bioinformatics that subsequently have been applied to numerous problems such as protein classification and others. Variable length modeling was originally pioneered by information theorists and subsequently ingeniously applied and popularized in data compression (e.g. Ziv-Lempel compression). Prediction and compression are intimately linked using Minimum Description Length Principles. The basic idea is to create a dictionary of frequent words (motifs in biological sequences). The intuition is that the frequently occurring motifs are likely to be most predictive and informative. In GLIMMER the interpolated model is a mixture model of the probabilities of these relatively common motifs. Similarly to the development of HMMs in Computational Biology, the authors of GLIMMER were conceptually influenced by the previous application of another variant of interpolated Markov models to speech recognition by researchers such as Fred Jelinek (IBM) and Eric Ristad (Princeton). The learning algorithm in GLIMMER is different from these earlier approaches. == Access == GLIMMER can be downloaded from The Glimmer home page (requires a C++ compiler). Alternatively, an online version is hosted by NCBI [1]. == How it works == GLIMMER primarily searches for long-ORFS. An open reading frame might overlap with any other open reading frame which will be resolved using the technique described in the sub section. Using these long-ORFS and following certain amino acid distribution GLIMMER generates training set data. Using these training data, GLIMMER trains all the six Markov models of coding DNA from zero to eight order and also train the model for noncoding DNA GLIMMER tries to calculate the probabilities from the data. Based on the number of observations, GLIMMER determines whether to use fixed order Markov model or interpolated Markov model. If the number of observations are greater than 400, GLIMMER uses fixed order Markov model to obtain there probabilities. If the number of observations are less than 400, GLIMMER uses interpolated Markov model which is briefly explained in the next sub section. GLIMMER obtains score for every long-ORF generated using all the six coding DNA models and also using non-coding DNA model. If the score obtained in the previous step is greater than a certain threshold then GLIMMER predicts it to be a gene. The steps explained above describes the basic functionality of GLIMMER. There are various improvements made to GLIMMER and some of them are described in the following sub-sections. === The GLIMMER system === GLIMMER system consists of two programs. First program called build-imm, which takes an input set of sequences and outputs the interpolated Markov model as follows. The probability for each base i.e., A,C,G,T for all k-mers for 0 ≤ k ≤ 8 is computed. Then, for each k-mer, GLIMMER computes weight. New sequence probability is computed as follows. where n is the length of the sequence S x {\displaystyle S_{x}} is the oligomer at position x. I M M 8 ( S x ) {\displaystyle IMM_{8}(S_{x})} , the 8 t h {\displaystyle 8^{th}} -order interpolated Markov model score is computed as "where Y k ( S x − 1 ) {\displaystyle Y_{k}(S_{x-1})} is the weight of the k-mer at position x-1 in the sequence S and P k ( S x ) {\displaystyle P_{k}(S_{x})} is the estimate obtained from the training data of the probability of the base located at position x in the k t h {\displaystyle k^{th}} -order model." The probability of base S x {\displaystyle S_{x}} given the i previous bases is computed as follows. "The value of Y i ( S x ) {\displaystyle Y_{i}(S_{x})} associated with P i ( S x ) {\displaystyle P_{i}(S_{x})} can be regarded as a measure of confidence in the accuracy of this value as an estimate of the true probability. GLIMMER uses two criteria to determine Y i ( S x ) {\displaystyle Y_{i}(S_{x})} . The first of these is simple frequency occurrence in which the number of occurrences of context string S x , i {\displaystyle S_{x,i}} in the training data exceeds a specific threshold value, then Y i ( S x ) {\displaystyle Y_{i}(S_{x})} is set to 1.0. The current default value for threshold is 400, which gives 95% confidence. When there are insufficient sample occurrences of a context string, build-imm employ additional criteria to determine Y {\displaystyle Y} value. For a

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  • AI Background Removers: Free vs Paid (2026)

    AI Background Removers: Free vs Paid (2026)

    Looking for the best AI background remover? An AI background remover is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI background remover slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.

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  • The Best Free AI Pair Programmer for Beginners

    The Best Free AI Pair Programmer for Beginners

    Comparing the best AI pair programmer? An AI pair programmer is software that uses machine learning to help you get more done — it lowers the barrier so anyone can produce professional output. Privacy matters too: check whether your data trains the model and whether a no-log or enterprise tier is available. Whether you are a beginner or a pro, the right AI pair programmer slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.

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  • Automated Lip Reading

    Automated Lip Reading

    Automated Lip Reading (ALR) is a software technology developed by speech recognition expert Frank Hubner. A video image of a person talking can be analysed by the software. The shapes made by the lips can be examined and then turned into sounds. The sounds are compared to a dictionary to create matches to the words being spoken. The technology was used successfully to analyse silent home movie footage of Adolf Hitler taken by Eva Braun at their Bavarian retreat Berghof. The video, with words, was included in a documentary titled "Hitler's Private World", Revealed Studios, 2006 Source: New Technology catches Hitler off guard

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  • The Best Free AI Blog Writer for Beginners

    The Best Free AI Blog Writer for Beginners

    Looking for the best AI blog writer? An AI blog writer is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI blog writer slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.

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  • Douwe Kiela

    Douwe Kiela

    Douwe Kiela is a Dutch-American research scientist and entrepreneur working in the field of artificial intelligence with a focus on machine learning and natural language processing. He is a research scientist director at Google DeepMind. He previously co-founded and served as CEO of Contextual AI, an enterprise software company that provides a platform for building grounded AI agents for enterprise knowledge bases. He previously led the research team at Meta AI that introduced the RAG approach in 2020, co-authoring the foundational paper "Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks." Kiela also served as Head of Research at Hugging Face and is an adjunct professor in Symbolic Systems at Stanford University. == Early life and education == Douwe Kiela was born in Amsterdam, Netherlands, in 1986. He earned a Bachelor of Science degree in Liberal Arts and Sciences from Utrecht University, with a double major in Cognitive Artificial Intelligence and Philosophy. He then obtained an MSc in logic (cum laude) from the University of Amsterdam's Institute for Logic, Language and Computation (ILLC). Kiela received an MPhil and PhD in Computer Science from the University of Cambridge, specializing in natural language processing and machine learning. == Career == === Facebook AI Research (Meta) === In 2016, Kiela joined Facebook AI Research (FAIR) as a postdoctoral researcher, later becoming a research scientist in New York. While at Meta, he co-authored papers in natural language processing, with a focus on multimodal and grounded language learning. His projects included creating a virtual assistant bot that could navigate tourists around a city and leading the development of Dynabench, an interactive benchmarking platform released in 2020 that used human feedback to test and improve language models. In 2020, Kiela led the Meta AI research team that introduced Retrieval-Augmented Generation (RAG), co-authoring the influential paper "Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks," alongside Patrick Lewis, Ethan Perez, and other researchers. The RAG framework transformed how large language models access and incorporate external information by allowing them to retrieve relevant context from external knowledge bases at query time, rather than relying solely on pre-trained data. This approach addressed key limitations such as hallucination, outdated information, and lack of source attribution. The RAG technique has since become widely adopted in enterprise AI applications and knowledge-intensive natural language processing tasks. === Hugging Face === After leaving Meta, Kiela served as Head of Research at Hugging Face. === Contextual AI === In 2023, Kiela co-founded Contextual AI with Amanpreet Singh, another former researcher at Facebook AI Research and Hugging Face. The Mountain View-based company develops a platform for building grounded AI agents for enterprises, focusing on applications in technology, semiconductor, logistics, finance, and media sectors. Contextual AI raised $20 million in seed funding in June 2023, led by Bain Capital Ventures. In August 2024, the company completed an $80 million Series A funding round led by Greycroft, with participation from Bezos Expeditions, NVentures (Nvidia), HSBC Ventures, and Snowflake Ventures, among others. In May 2026, Kiela joined Google DeepMind as part of a licensing agreement between Google and Contextual AI under which more than 20 Contextual AI researchers joined DeepMind. Following his departure, Jay Chen became interim CEO of Contextual AI. === Academic roles === Douwe Kiela serves as an adjunct professor in Symbolic Systems at Stanford University. In a 2023 interview with the Stanford Daily, he commented on the development of Alpaca, a low-cost instruction-finetuned model based on Meta's LLaMA, and emphasized the importance of open academic research in large language models.

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  • Best AI Avatar Generators in 2026

    Best AI Avatar Generators in 2026

    Looking for the best AI avatar generator? An AI avatar generator is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI avatar generator slots into your workflow and pays for itself fast. This guide breaks down the top picks, their pros and cons, and who each one is best for.

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  • GeneRIF

    GeneRIF

    A GeneRIF or Gene Reference Into Function is a short (255 characters or fewer) statement about the function of a gene. GeneRIFs provide a simple mechanism for allowing scientists to add to the functional annotation of genes described in the Entrez Gene database. In practice, function is constructed quite broadly. For example, there are GeneRIFs that discuss the role of a gene in a disease, GeneRIFs that point the viewer towards a review article about the gene, and GeneRIFs that discuss the structure of a gene. However, the stated intent is for GeneRIFs to be about gene function. Currently over half a million geneRIFs have been created for genes from almost 1000 different species. GeneRIFs are always associated with specific entries in the Entrez Gene database. Each GeneRIF has a pointer to the PubMed ID (a type of document identifier) of a scientific publication that provides evidence for the statement made by the GeneRIF. GeneRIFs are often extracted directly from the document that is identified by the PubMed ID, very frequently from its title or from its final sentence. GeneRIFs are usually produced by NCBI indexers, but anyone may submit a GeneRIF. To be processed, a valid Gene ID must exist for the specific gene, or the Gene staff must have assigned an overall Gene ID to the species. The latter case is implemented via records in Gene with the symbol NEWENTRY. Once the Gene ID is identified, only three types of information are required to complete a submission: a concise phrase describing a function or functions (less than 255 characters in length, preferably more than a restatement of the title of the paper); a published paper describing that function, implemented by supplying the PubMed ID of a citation in PubMed; a valid e-mail address (which will remain confidential). == Example == Here are some GeneRIFs taken from Entrez Gene for GeneID 7157, the human gene TP53. The PubMed document identifiers have been omitted from the examples. Note the wide variability with respect to the presence or absence of punctuation and of sentence-initial capital letters. p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. GeneRIFs are an unusual type of textual genre, and they have recently been the subject of a number of articles from the natural language processing community.

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  • Hebbian theory

    Hebbian theory

    Hebbian theory is a neuropsychological theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. It is an attempt to explain synaptic plasticity, the adaptation of neurons during the learning process. Hebbian theory was introduced by Donald Hebb in his 1949 book The Organization of Behavior. The theory is also called Hebb's rule, Hebb's law, Hebb's postulate, and cell assembly theory. Hebb states it as follows: Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability. ... When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased. The theory is often summarized as "Neurons that fire together, wire together." However, Hebb emphasized that cell A needs to "take part in firing" cell B, and such causality can occur only if cell A fires just before, not at the same time as, cell B. This aspect of causation in Hebb's work foreshadowed what is now known about spike-timing-dependent plasticity, which requires temporal precedence. Hebbian theory attempts to explain associative or Hebbian learning, in which simultaneous activation of cells leads to pronounced increases in synaptic strength between those cells. It also provides a biological basis for errorless learning methods for education and memory rehabilitation. In the study of neural networks in cognitive function, it is often regarded as the neuronal basis of unsupervised learning. == Engrams, cell assembly theory, and learning == Hebbian theory provides an explanation for how neurons might connect to become engrams, which may be stored in overlapping cell assemblies, or groups of neurons that encode specific information. Initially created as a way to explain recurrent activity in specific groups of cortical neurons, Hebb's theories on the form and function of cell assemblies can be understood from the following: The general idea is an old one, that any two cells or systems of cells that are repeatedly active at the same time will tend to become 'associated' so that activity in one facilitates activity in the other. Hebb also wrote: When one cell repeatedly assists in firing another, the axon of the first cell develops synaptic knobs (or enlarges them if they already exist) in contact with the soma of the second cell. D. Alan Allport posits additional ideas regarding cell assembly theory and its role in forming engrams using the concept of auto-association, or the brain's ability to retrieve information based on a partial cue, described as follows: If the inputs to a system cause the same pattern of activity to occur repeatedly, the set of active elements constituting that pattern will become increasingly strongly inter-associated. That is, each element will tend to turn on every other element and (with negative weights) to turn off the elements that do not form part of the pattern. To put it another way, the pattern as a whole will become 'auto-associated'. We may call a learned (auto-associated) pattern an engram. Research conducted in the laboratory of Nobel laureate Eric Kandel has provided evidence supporting the role of Hebbian learning mechanisms at synapses in the marine gastropod Aplysia californica. Because synapses in the peripheral nervous system of marine invertebrates are much easier to control in experiments, Kandel's research found that Hebbian long-term potentiation along with activity-dependent presynaptic facilitation are both necessary for synaptic plasticity and classical conditioning in Aplysia californica. While research on invertebrates has established fundamental mechanisms of learning and memory, much of the work on long-lasting synaptic changes between vertebrate neurons involves the use of non-physiological experimental stimulation of brain cells. However, some of the physiologically relevant synapse modification mechanisms that have been studied in vertebrate brains do seem to be examples of Hebbian processes. One such review indicates that long-lasting changes in synaptic strengths can be induced by physiologically relevant synaptic activity using both Hebbian and non-Hebbian mechanisms. == Principles == In artificial neurons and artificial neural networks, Hebb's principle can be described as a method of determining how to alter the weights between model neurons. The weight between two neurons increases if the two neurons activate simultaneously, and reduces if they activate separately. Nodes that tend to be either both positive or both negative at the same time have strong positive weights, while those that tend to be opposite have strong negative weights. The following is a formulaic description of Hebbian learning (many other descriptions are possible): w i j = x i x j , {\displaystyle \,w_{ij}=x_{i}x_{j},} where w i j {\displaystyle w_{ij}} is the weight of the connection from neuron j {\displaystyle j} to neuron i {\displaystyle i} , and x i {\displaystyle x_{i}} is the input for neuron i {\displaystyle i} . This is an example of pattern learning, where weights are updated after every training example. In a Hopfield network, connections w i j {\displaystyle w_{ij}} are set to zero if i = j {\displaystyle i=j} (no reflexive connections allowed). With binary neurons (activations either 0 or 1), connections would be set to 1 if the connected neurons have the same activation for a pattern. When several training patterns are used, the expression becomes an average of the individuals: w i j = 1 p ∑ k = 1 p x i k x j k , {\displaystyle w_{ij}={\frac {1}{p}}\sum _{k=1}^{p}x_{i}^{k}x_{j}^{k},} where w i j {\displaystyle w_{ij}} is the weight of the connection from neuron j {\displaystyle j} to neuron i {\displaystyle i} , p {\displaystyle p} is the number of training patterns and x i k {\displaystyle x_{i}^{k}} the k {\displaystyle k} -th input for neuron i {\displaystyle i} . This is learning by epoch, with weights updated after all the training examples are presented and is last term applicable to both discrete and continuous training sets. Again, in a Hopfield network, connections w i j {\displaystyle w_{ij}} are set to zero if i = j {\displaystyle i=j} (no reflexive connections). A variation of Hebbian learning that takes into account phenomena such as blocking and other neural learning phenomena is the mathematical model of Harry Klopf. Klopf's model assumes that parts of a system with simple adaptive mechanisms can underlie more complex systems with more advanced adaptive behavior, such as neural networks. == Relationship to unsupervised learning, stability, and generalization == Because of the simple nature of Hebbian learning, based only on the coincidence of pre- and post-synaptic activity, it may not be intuitively clear why this form of plasticity leads to meaningful learning. However, it can be shown that Hebbian plasticity does pick up the statistical properties of the input in a way that can be categorized as unsupervised learning. This can be mathematically shown in a simplified example. Let us work under the simplifying assumption of a single rate-based neuron of rate y ( t ) {\displaystyle y(t)} , whose inputs have rates x 1 ( t ) . . . x N ( t ) {\displaystyle x_{1}(t)...x_{N}(t)} . The response of the neuron y ( t ) {\displaystyle y(t)} is usually described as a linear combination of its input, ∑ i w i x i {\displaystyle \sum _{i}w_{i}x_{i}} , followed by a response function f {\displaystyle f} : y = f ( ∑ i = 1 N w i x i ) . {\displaystyle y=f\left(\sum _{i=1}^{N}w_{i}x_{i}\right).} As defined in the previous sections, Hebbian plasticity describes the evolution in time of the synaptic weight w {\displaystyle w} : d w i d t = η x i y . {\displaystyle {\frac {dw_{i}}{dt}}=\eta x_{i}y.} Assuming, for simplicity, an identity response function f ( a ) = a {\displaystyle f(a)=a} , we can write d w i d t = η x i ∑ j = 1 N w j x j {\displaystyle {\frac {dw_{i}}{dt}}=\eta x_{i}\sum _{j=1}^{N}w_{j}x_{j}} or in matrix form: d w d t = η x x T w . {\displaystyle {\frac {d\mathbf {w} }{dt}}=\eta \mathbf {x} \mathbf {x} ^{T}\mathbf {w} .} As in the previous chapter, if training by epoch is done an average ⟨ … ⟩ {\displaystyle \langle \dots \rangle } over discrete or continuous (time) training set of x {\displaystyle \mathbf {x} } can be done: d w d t = ⟨ η x x T w ⟩ = η ⟨ x x T ⟩ w = η C w . {\displaystyle {\frac {d\mathbf {w} }{dt}}=\langle \eta \mathbf {x} \mathbf {x} ^{T}\mathbf {w} \rangle =\eta \langle \mathbf {x} \mathbf {x} ^{T}\rangle \mathbf {w} =\eta C\mathbf {w} .} where C = ⟨ x x T ⟩ {\displaystyle C=\langle \,\mathbf {x} \mathbf {x} ^{T}\rangle } is the correlation matrix of the input under the additional assumption that ⟨ x ⟩ = 0 {\displaystyle \langle \mathbf

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  • Emergent (software)

    Emergent (software)

    Emergent (formerly PDP++) is a biologically-based neural simulation software that is primarily intended for creating models of the brain and cognitive processes. Development initially began in 1995 at Carnegie Mellon University, and as of 2014, continues at the University of Colorado at Boulder. The 3.x release of the software, which was known as PDP++, is featured in the textbook Computational Explorations in Cognitive Neuroscience. == Features == Emergent features a modular design, based on the principles of object-oriented programming. It runs on Microsoft Windows, Darwin / macOS and Linux. C-Super-Script (variously, CSS and C^C), a built-in C++-like interpreted scripting language, allows access to virtually all simulator objects and can initiate all the same actions as the GUI, and more. Version 4 and upward features a full 3D environment for visualizations, based on Qt and Open Inventor. Robotics simulations are made possible by integration with the Open Dynamics Engine. A plugin system allows for expanding the software in many ways. Version 5 introduced parallel threading support, numerous speed improvements, a help browser featuring an interface to the project's Wiki and auto-generated documentation, undo and redo using diffs and a definable undo depth. In addition, 5.0.2 introduced a built-in plugin source code editor, and plugins can now be compiled from the main interface, enabling full development of plugins within Emergent. Emergent also provides an implementation of Leabra which was developed by Randall C. O'Reilly in his PhD thesis.

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