AI Email Generator

AI Email Generator — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

  • Alerts.in.ua

    Alerts.in.ua

    alerts.in.ua is an online service that visualizes information about air alerts and other threats on the map of Ukraine. == History == The idea of the site appeared in the first weeks of the 2022 Russian invasion of Ukraine, during the development of other projects related to alerting the population about alarms. So, on March 2, 2022, the "Lviv Siren" bot was created, which reported on air alarms in Lviv on Twitter. Later, the idea arose to monitor alarms all over Ukraine and display them on a map. However, the lack of a single official source reporting alarms made this task much more difficult. On March 15, 2022, the Ajax Systems company announced the creation of the official Telegram channel "Air Alarm". This channel receives signals from the "Air Alarm" application and instantly publishes messages about the start and end of alarms in different regions of Ukraine. This immediately solved the problem with the source of information and gave impetus to the further implementation of the project. On March 22, 2022, the first version of the "Air Alarm Map" website was published, located on the war.ukrzen.in.ua domain. The map quickly gained popularity in social networks. It, like several other similar projects, began to be widely distributed by the mass media: Suspilne, Novyi Kanal, UNIAN, DW, Fakty ICTV, Vikna TV, Ukrainian Radio, STB, Espresso, dev.ua, itc.ua and state bodies: Center for Countering Disinformation at the National Security and Defense Council of Ukraine, Verkhovna Rada of Ukraine, Khmelnytska OVA, etc. On April 8, 2022, the site moved to the alerts.in.ua domain, where it is still available today. On August 25, 2022, the service began monitoring local official channels in addition to the main "Air Alarm". On September 11, 2022, the English version of the site was published. On March 22, 2023, its own Android application was published. The project is actively developing and has its own community. == Description == The main part of the site is a map of Ukraine, on which the regions where an air alert or other threats have been declared are highlighted in real time. As of October 16, 2022, 5 types of threats are supported: Air alarm. The threat of artillery fire. The threat of street fighting. Chemical threat. Nuclear threat. Additionally, based on media reports, information is published about other dangerous events, such as explosions, demining, etc. On the site, you can view the history of announced alarms with links to sources. Alarm statistics for different time periods are also available. For developers, there is an API that allows you to develop your own services based on information about declared alarms. The site is available in Ukrainian, English, Polish and Japanese. == Use == The map is used by: To monitor the situation in the country and the region. To illustrate the alarms announced in the mass media: TSN, Ukrainian truth, Channel 24, Suspilne, RBC Ukraine, Gromadske, Glavkom. As a map of alarms in mobile applications, there is Alarm and AirAlert. As an API for its services, including alternative alarm maps, Telegram, Viber channels, Discord bots, IoT projects, etc. == Statistics == 89.5% of users use the map from a mobile phone, 10% from a PC and 1% from a tablet. Top 6 countries by visit: Ukraine, United States, Poland, Germany, Great Britain and Japan . == Alternative projects == eMap was created by the developer Vadym Klymenko. AlarmMap is an online from the Ukrainian office of Agroprep. The official map of air alarms was developed by Ajax Systems together with the developer Artem Lemeshev, Stfalcon with the support of the Ministry of Statistics.

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  • Teamwork (project management)

    Teamwork (project management)

    Teamwork.com is an Irish, privately owned, web-based software company headquartered in Cork, Ireland. Teamwork creates task management and team collaboration software. Founded in 2007, as of 2016 the company stated that its software was in use by over 370,000 organisations worldwide (including Disney, Spotify and HP), and that it had over 2.4m users. == History == Peter Coppinger and Dan Mackey founded a company, Digital Crew, in 2007. This company built websites, intranets and custom web-based solutions for clients in Cork, Ireland. Frustrated by whiteboards and software management tools, Coppinger wanted a software system that would help manage client projects and which would be easy to use and generic enough to be used by different types of companies. Originally 37signals Basecamp users themselves, Coppinger and Mackey were frustrated by the limited feature set, and by Basecamp's apparent inaction on their feedback. In October 2007, Coppinger and Mackey launched Teamwork Project Manager, nicknamed TeamworkPM. In March 2015, this was renamed as Teamwork Projects. In 2014, after two years of negotiations, TeamworkPM bought the domain name 'Teamwork.com' for US$675,000 (€500,000). At the time this was one of the most expensive domain name purchases by an Irish company, and involved the transfer of a domain name which had been dormant since it was first acquired by the original owner in 1999. In 2015, Teamwork.com was named by Gartner to be one of their "Cool Vendors" in the Program and Portfolio Management Category. This was followed by the launch of a new real-time messaging product, Teamwork Chat, in January 2015. In June 2015, the company announced a drive to recruit for 40 positions by the end of the year. This was followed by the announcement that the company was investing more than €1 million in a new office, and had leased office space in Park House, Blackpool. In June 2016, Teamwork.com undertook a further recruitment drive to entice developers to Cork. In July 2021, the company announced that it had raised an investment of $70 million (€59.1 million) from venture capital firm Bregal Milestone to fund further growth. == Products == Teamwork markets a number of cloud-based applications, including Teamwork, Teamwork Desk, Teamwork Spaces, Teamwork CRM and Teamwork Chat. Teamwork was launched on 4 October 2007, at which time it had time management, milestone management, file sharing, time tracking, and messaging features. Teamwork's platform reportedly integrates with martech software like HubSpot, as well as other productivity tools like Slack, G Suite, MS Teams, Zapier, Dropbox and QuickBooks. == Awards == In 2016, Teamwork was awarded Cork's Best SME in the Cork Chamber of Commerce "Company of the Year" awards. In 2016, Teamwork was named number 7 in Deloitte's Fast 50 tech companies hit €1.6bn turnover. In 2015, Teamwork was identified as a Gartner "Cool Vendor" in the Program and Portfolio Management Category.

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  • Clean Email

    Clean Email

    Clean Email is an automated software as a service email management application which identifies and clears junk mail from inboxes. The service uses a subscription business model with a free trial for the first 1,000 emails. and is available on macOS, iOS, Android, and on the web. == History == Clean Email is a self-funded company headquartered in Los Angeles, California. Initially developed by the founder for personal use, the service was designed to address the growing issue of inbox clutter and privacy concerns. In 2017, John Gruber recognized Clean Email as a trustworthy alternative to Unroll.me after the latter was found to be selling user data. == Features == Clean Email uses algorithms to identify and categorize emails, enabling users to group, remove, label, and archive email messages in bulk. Its Unsubscriber tool consolidates all subscriptions and newsletters into a single view for quick management, allowing users to bulk unsubscribe or temporarily pause mail. Its Screener feature transforms the inbox into an "opt-in" system, enabling users to pre-approve mail from new senders. Cleaning Suggestions identifies frequently cleaned mail, recommending actions accordingly. Additional functionalities include automatic deletion of aging emails, delivery of messages to specified folders, and options to mute or block senders.

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  • Tabletopia

    Tabletopia

    Tabletopia is an online portal for users to play and create virtual tabletop games. The platform is developed by Tabletopia Inc and initially was released as a web browser based service after a successful crowdfunding campaign in August 2015. In December 2016 Tabletopia was released on Steam, and later in 2018 became available in AppStore and Google Play. == Gameplay == Tabletopia is a sandbox system for running any game. That means no AI or rules enforcement. Participating players will have to know how to play the game. Nevertheless, the platform has some automated actions available, like card-shuffling and dealing, dice-rolling, magnetic placement of components in special zones, hand management, and some others. Tabletopia also features ready game setups for various player numbers to facilitate gameplay. It also has customisable camera controls which let players save camera positions and switch between them using hot keys. People can use the Game Designer mode to design and create their own board games using the component library. They can then monetise the games with a 70/30 split to the game designer. == Development == Tabletopia was created in early 2014, by Tim Bokarev and his partners Artem Zinoviev and Dmitry Sergeev. These co-founders already had experience in the video and board games industry. Their other projects include Promo Interactive, an internet advertising agency, Playtox, a mobile MMORPG, Igrology, a game studio, and Tesera.ru, the main Russian-speaking board gaming portal. By Spring 2014, Artem, Dmitry and Tim created Tabletopia Inc. USA and started development. Tabletopia is a multinational crew that includes professionals from USA, Ukraine, Australia, Ireland, and Germany. The Kickstarter campaign in August 2015 earned $133,721 by 2,545 backers. Tabletopia received Green Light on Steam in September 2015 and was released on Steam in March 2016. The platform remained in Early Access until December 2016, when it was officially released on Steam and on the web. In February 2018 it was released as a stand-alone app for iOS tablets, and in September 2018 for Android tablets.

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  • System appreciation

    System appreciation

    System appreciation is an activity often included in the maintenance phase of software engineering projects. Key deliverables from this phase include documentation that describes what the system does in terms of its functional features, and how it achieves those features in terms of its architecture and design. Software architecture recovery is often the first step within System appreciation.

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  • Oracle Cloud Platform

    Oracle Cloud Platform

    Oracle Cloud Platform refers to a Platform as a Service (PaaS) offerings by Oracle Corporation as part of Oracle Cloud Infrastructure. These offerings are used to build, deploy, integrate and extend applications in the cloud. The offerings support a variety of programming languages, databases, tools and frameworks including Oracle-specific, open source and third-party software and systems. == Deployment models == Oracle Cloud Platform offers public, private and hybrid cloud deployment models. == Architecture == Oracle Cloud Platform provides both Infrastructure as a Service (IaaS) and Platform as a Service (PaaS). The infrastructure is offered through a global network of Oracle managed data centers. Oracle deploys their cloud in Regions. Inside each Region are at least three fault-independent Availability Domains. Each of these Availability Domains contains an independent data center with power, thermal and network isolation. Oracle Cloud is generally available in North America, EMEA, APAC and Japan with announced South America and US Govt. regions coming soon.

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  • Structural synthesis of programs

    Structural synthesis of programs

    Structural synthesis of programs (SSP) is a special form of (automatic) program synthesis that is based on propositional calculus. More precisely, it uses intuitionistic logic for describing the structure of a program in such a detail that the program can be automatically composed from pieces like subroutines or even computer commands. It is assumed that these pieces have been implemented correctly, hence no correctness verification of these pieces is needed. SSP is well suited for automatic composition of services for service-oriented architectures and for synthesis of large simulation programs. == History == Automatic program synthesis began in the artificial intelligence field, with software intended for automatic problem solving. The first program synthesizer was developed by Cordell Green in 1969. At about the same time, mathematicians including R. Constable, Z. Manna, and R. Waldinger explained the possible use of formal logic for automatic program synthesis. Practically applicable program synthesizers appeared considerably later. The idea of structural synthesis of programs was introduced at a conference on algorithms in modern mathematics and computer science organized by Andrey Ershov and Donald Knuth in 1979. The idea originated from G. Pólya’s well-known book on problem solving. The method for devising a plan for solving a problem in SSP was presented as a formal system. The inference rules of the system were restructured and justified in logic by G. Mints and E. Tyugu in 1982. A programming tool PRIZ that uses SSP was developed in the 1980s. A recent Integrated development environment that supports SSP is CoCoViLa — a model-based software development platform for implementing domain specific languages and developing large Java programs. == The logic of SSP == Structural synthesis of programs is a method for composing programs from already implemented components (e.g. from computer commands or software object methods) that can be considered as functions. A specification for synthesis is given in intuitionistic propositional logic by writing axioms about the applicability of functions. An axiom about the applicability of a function f is a logical implication X1 ∧ X2 ∧ ... ∧ Xm → Y1 ∧ Y2 ... Yn, where X1, X2, ... Xm are preconditions and Y1, Y2, ... Yn are postconditions of the application of the function f. In intuitionistic logic, the function f is called a realization of this formula. A precondition can be a proposition stating that input data exists, e.g. Xi may have the meaning “variable xi has received a value”, but it may denote also some other condition, e.g. that resources needed for using the function f are available, etc. A precondition may also be an implication of the same form as the axiom given above; then it is called a subtask. A subtask denotes a function that must be available as an input when the function f is applied. This function itself must be synthesized in the process of SSP. In this case, realization of the axiom is a higher order function, i.e., a function that uses another function as an input. For instance, the formula (state → nextState) ∧ initialState → result can specify a higher order function with two inputs and an output result. The first input is a function that has to be synthesized for computing nextState from state, and the second input is initialState. Higher order functions give generality to the SSP – any control structure needed in a synthesized program can be preprogrammed and used then automatically with a respective specification. In particular, the last axiom presented here is a specification of a complex program – a simulation engine for simulating dynamic systems on models where nextState can be computed from state of the system.

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  • Hancom Office

    Hancom Office

    Hancom Office is a proprietary office suite that includes a word processor, spreadsheet software, presentation software, and a PDF editor as well as their online versions accessible via a web browser. It is primarily addressed to Korean users. Hancom Office is written in Java and C++ that runs on Android, iOS, macOS and Windows platforms. == Products == Hangul - Hangul is a word processor developed by Hancom. It is a product that eliminates the inconvenience of the original Hangul word processor, which was limited to Hangul cards or PC models. Originally, the name was written using the '아래아' character, a vowel letter that is obsolete in modern Korean, and it was referred to as 'HWP' (an abbreviation for Hangul Word Processor), '아래아 한글' (Arae-a Hangul), '한/글' (Han/Geul), and so on. Hangul is currently the most widely used word processor in South Korea, often used alongside Microsoft Word. HanWord - word processor compatible with Word HanCell - spreadsheet program HanShow - presentation program Hancom Office Hanword Viewer - For viewing documents created by Hancom Office or Microsoft Office

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  • AI Security Institute

    AI Security Institute

    The AI Security Institute (AISI) is a research organisation under the Department for Science, Innovation and Technology, UK, that aims "to equip governments with a scientific understanding of the risks posed by advanced AI". It conducts research and develop and test mitigations. Previously, it was known as the AI Safety Institute. Its creation followed world's first major AI Safety Summit that was held in Bletchley Park in 2023. The institute's professed goal is "building the world's leading understanding of advanced AI risks and solutions, to inform governments so they can keep the public safe". It is designed like a startup in the government "combining the authority of government with the expertise and agility of the private sector". AISI has made access agreements with Anthropic, Google and OpenAI to test their models before release. It has an open source platform called Inspect that permits companies, governments and academics to run standardised safety tests for AI usage. Among the works AISI has done is the reported detection of multiple serious vulnerabilities that could enable development of biological weapons; the vulnerabilities were fixed before the model was launched. It conducts research on diverse fields of AI application. One study by AISI found that LLMs post-trained for political persuasiveness became systematically less accurate and up to 51% more persuasive on political issues. AISI has also worked on the usage of AI for emotional needs. It found that nearly 10 percent of UK citizens used systems like chatbots for emotional purposes on a weekly basis. It found that "systems are now outperforming PhD-level researchers on scientific knowledge tests and helping non-experts succeed at lab work that would previously have been out of reach" in a report published in December 2025. Former chief AI officer of GCHQ Adam Beaumont is the institution's interim director. UK prime minister's AI advisor Jade Leung is the chief technology officer.

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  • LemonStand

    LemonStand

    LemonStand was a Canadian e-commerce company headquartered in Vancouver, British Columbia, that developed cloud-based computer software for online retailers. LemonStand was shut down on June 5, 2019. == History == LemonStand Version 1 was launched on July 28, 2001. It is written in the PHP programming language. Version 1 was released as an on-premises proprietary licensed software, and the commercial license was not free. However, there was a free trial license available. June 2012, LemonStand raised seed funding from the BDC Venture Capital, and a group of angel investors. December 20, 2013, a cloud-based SaaS version of the LemonStand eCommerce platform was released publicly. May 9, 2014, LemonStand and Payfirma, a payments processing company, partnered to provide integrated services for online retailers. May 3, 2016, LemonStand raised funding from BDC Venture Capital and Silicon Valley–based angel investors. March 5, 2019, LemonStand announced their intention to shut down on June 5, 2019. LemonStand was quietly acquired by Mailchimp at the end of February. == Pricing == LemonStand offered three levels of service plans. LemonStand did not charge any transaction fees.

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  • Cloud-based quantum computing

    Cloud-based quantum computing

    Cloud-based quantum computing refers to the remote access of quantum computing resources—such as quantum emulators, simulators, or processors—via the internet. Cloud access enables users to develop, test, and execute quantum algorithms without the need for direct interaction with specialized hardware, facilitating broader participation in quantum software development and experimentation. In 2016, IBM launched the IBM Quantum Experience, one of the first publicly accessible quantum processors connected to the cloud. In early 2017, researchers at Rigetti Computing demonstrated programmable quantum cloud access through their software platform Forest, which included the pyQuil Python library. Since the early-2020s, cloud-based quantum computing has grown significantly, with multiple providers offering access to a variety of quantum hardware modalities, including superconducting qubits, trapped ions, neutral atoms, and photonic systems. Major platforms such as Amazon Braket, Azure Quantum, and qBraid aggregate quantum devices from hardware developers like IonQ, Rigetti Computing, QuEra, Pasqal, Oxford Quantum Circuits, and IBM Quantum. These platforms provide unified interfaces for users to write and execute quantum algorithms across diverse backends, often supporting open-source SDKs such as Qiskit, Cirq, and PennyLane. The proliferation of cloud-based access has played a key role in accelerating quantum education, algorithm research, and early-stage application development by lowering the barrier to experimentation with real quantum hardware. Cloud-based quantum computing has expanded access to quantum hardware and tools beyond traditional research laboratories. These platforms support educational initiatives, algorithm development, and early-stage commercial applications. == Applications == Cloud-based quantum computing is used across education, research, and software development, offering remote access to quantum systems without the need for on-site infrastructure. === Education === Quantum cloud platforms have become valuable tools in education, allowing students and instructors to engage with real quantum processors through user-friendly interfaces. Educators use these platforms to teach foundational concepts in quantum mechanics and quantum computing, as well as to demonstrate and implement quantum algorithms in a classroom or laboratory setting. === Scientific Research === Cloud-based access to quantum hardware has enabled researchers to conduct experiments in quantum information, test quantum algorithms, and compare quantum hardware platforms. Experiments such as testing Bell's theorem or evaluating quantum teleportation protocols have been performed on publicly available quantum processors. === Software Development and Prototyping === Developers use cloud-based platforms to prototype quantum software applications across fields such as optimization, machine learning, and chemistry. These platforms offer SDKs and APIs that integrate classical and quantum workflows, enabling experimentation with quantum algorithms in real-world or simulated environments. === Public Engagement and Games === Quantum cloud tools have also been used to create educational games and interactive applications aimed at increasing public understanding of quantum concepts. These efforts help bridge the gap between theoretical content and intuitive learning. == Existing platforms == qBraid Lab by qBraid is a cloud-based platform for quantum computing. It provides software tools for researchers and developers in quantum, as well as access to quantum hardware. qBraid provides cloud based access to Microsoft Azure Quantum and Amazon Braket devices including IQM, QuEra, Pasqal, Rigetti, IonQ, QIR simulators, Amazon Braket simulators, and the NEC Vector Annealer, as of August 2025. qBraid's base version is free, where unlimited hardware and simulator access is available with the purchase of credits. Quandela Cloud by Quandela is the platform to access first cloud-accessible European photonic quantum computer. The computer is interfaced using the Perceval scripting language, with tutorials and documentation available online for free. Xanadu Quantum Cloud by Xanadu is a platform with cloud-based access to three fully programmable photonic quantum computers. Forest by Rigetti Computing is a tool suite for cloud-based quantum computing. It includes a programming language, development tools and example algorithms. LIQUi> by Microsoft is a software architecture and tool suite for quantum computing. It includes a programming language, example optimization and scheduling algorithms, and quantum simulators. Q#, a quantum programming language by Microsoft on the .NET Framework seen as a successor to LIQUi|>. IBM Quantum Platform by IBM, providing access to quantum hardware as well as HPC simulators. These can be accessed programmatically using the Python-based Qiskit framework, or via graphical interface with the IBM Q Experience GUI. Both are based on the OpenQASM standard for representing quantum operations. There is also a tutorial and online community. Quantum in the Cloud by The University of Bristol, which consists of a quantum simulator and a four qubit optical quantum system. Quantum Playground by Google is an educational resource which features a simulator with a simple interface, and a scripting language and 3D quantum state visualization. Quantum in the Cloud is an experimental quantum cloud platform for access to a four-qubit nuclear magnetic resonance-NMRCloudQ computer, managed by Tsinghua University. Quantum Inspire by Qutech is the first platform in Europe providing cloud-based quantum computing to two hardware chips. Next to a 5-qubit transmon processor, Quantum Inspire is the first platform in the world to provide online access to a fully programmable 2-qubit electron spin quantum processor. Amazon Braket is a cloud-based quantum computing platform hosted by AWS which, as of June 2025, provides access to quantum computers built by IonQ, Rigetti, IQM, and QuEra. Braket also provides a quantum algorithm development environment and simulator. Forge by QC Ware is a cloud-based quantum computing platform that provides access to D-Wave hardware, as well as Google and IBM simulators. The platform offers a 30-day free trial, including one minute of quantum computing time. Quantum-as-a-Service by Scaleway is a cloud-based platform created in 2022 to access to real quantum hardware from IQM Quantum Computers, Alpine Quantum Technologies, Quandela and Pasqal. It also include access to GPU-powered emulators such as Aer, Qsim and Quandela proprietary emulation.

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  • Visual Expert

    Visual Expert

    Visual Expert is a static code analysis tool, extracting design and technical information from software source code by reverse-engineering, used by programmers for software maintenance, modernization or optimization. It is designed to parse several programming languages at the same time (PL/SQL, Transact-SQL, PowerBuilder...) and analyze cross-language dependencies, in addition to each language's source code. Visual Expert checks source code against hundreds of code inspection rules for vulnerability assessment, bug fix, and maintenance issues. == Features == Cross-references exploration: Impact Analysis, E/R diagrams, call graphs, CRUD matrix, dependency graphs. Software documentation: a documentation generator produces technical documentation and low-level design descriptions. Inspect the code to detect bugs, security vulnerabilities and maintainability issues. Native integration with Jenkins. Reports on duplicate code, unused objects and methods and naming conventions. Calculates software metrics and source lines of code. Code comparison: finds differences between several versions of the same code. Performance analysis: identifies code parts that slow down the application because of their syntax - it extracts statistics about code execution from the database and combines it with the static analysis of the code. == Usage == Visual Expert is used in several contexts: Change impact analysis: evaluating the consequences of a change in the code or in a database. Avoiding negative side effects when evolving a system. Static Application Security Testing (SAST): detecting and removing security issues. Continuous Integration / Continuous Inspection : adding a static code analysis job in a CI/CD workflow to automatically verify the quality and security of a new build when it is released. Program comprehension: helping programmers understand and maintain existing code, or modernize legacy systems. Transferring knowledge of the code, from one programmer to another. Software sizing: calculating the size of an application, or a piece of code, in order to estimate development efforts. Code review: improving the code by finding and removing code smells, dead code, code causing poor performances or violations of coding conventions. == Limitations == As a static code analyzer, Visual Expert is limited to the programming languages supported by its code parsers - Oracle PL/SQL, SQL Server Transact-SQL, PowerBuilder. A preliminary reverse engineering is required. Visual Expert does it automatically, but its duration depends on the size of the code parsed. Users must wait for the parsing completion prior to using the features, or schedule it in advance. They must also allocate sufficient hardware resources to support their volume of code. Visual Expert is based on a client/server architecture: the code analysis is running on a Windows PC - preferably a server. The information extracted from the code is stored in a RDBMS, communicating with a client application installed on the programmer's computer - no web client is available. This requires that the code, the parsers, the RDBMS and the programmers’ computers are connected to the same LAN or VPN. == History == 1995- 1998 - Prog and Doc - Initial version distributed on the French market 2001 - Visual Expert 4.5 2003 - Visual Expert 5 2007 - Visual Expert 5.7 2010 - Visual Expert 6.0 2015 - Visual Expert 2015 - Server component added to schedule code analyses 2016 - Visual Expert 2016 - Oracle PL/SQL code parser, code inventory (lines of code, number of objects…) 2017 - Visual Expert 2017 - SQL Server T-SQL code parser, Code comparison, CRUD matrix 2018 - Visual Expert 2018 - DB Code Performance Analysis, integration with TFS 2019 - Visual Expert 2019 - Generation of E/R diagrams from the code 2020 - Visual Expert 2020 - Object dependency matrix, naming consistency verification, integration with GIT and SVN 2021 - Visual Expert 2021 - Continuous Code Inspection, integration with Jenkins 2022 - Visual Expert 2022 - Support for cloud-based repositories and large volumes of code 2023 - Visual Expert 2023 - Performance tuning for PowerBuilder 2024 - Visual Expert 2024 - New web UI to simplify deployment and use among large teams. 2025 - Visual Expert 2025 - AI-based features to explain code, generate comments, and optimize queries

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  • Projection-slice theorem

    Projection-slice theorem

    In mathematics, the projection-slice theorem, central slice theorem or Fourier slice theorem in two dimensions states that the results of the following two calculations are equal: Take a two-dimensional function f(r), project (e.g. using the Radon transform) it onto a (one-dimensional) line, and do a Fourier transform of that projection. Take that same function, but do a two-dimensional Fourier transform first, and then slice the function through its origin, parallel to the projection line. In operator terms, if F1 and F2 are the 1- and 2-dimensional Fourier transform operators mentioned above, P1 is the projection operator (which projects a 2-D function onto a 1-D line), S1 is a slice operator (which extracts a 1-D central slice from a function), then F 1 P 1 = S 1 F 2 . {\displaystyle F_{1}P_{1}=S_{1}F_{2}.} This idea can be extended to higher dimensions. This theorem is used, for example, in the analysis of medical CT scans where a "projection" is an x-ray image of an internal organ. The Fourier transforms of these images are seen to be slices through the Fourier transform of the 3-dimensional density of the internal organ, and these slices can be interpolated to build up a complete Fourier transform of that density. The inverse Fourier transform is then used to recover the 3-dimensional density of the object. This technique was first derived by Ronald N. Bracewell in 1956 for a radio-astronomy problem. == The projection-slice theorem in N dimensions == In N dimensions, the projection-slice theorem states that the Fourier transform of the projection of an N-dimensional function f(r) onto an m-dimensional linear submanifold is equal to an m-dimensional slice of the N-dimensional Fourier transform of that function consisting of an m-dimensional linear submanifold through the origin in the Fourier space which is parallel to the projection submanifold. In operator terms: F m P m = S m F N . {\displaystyle F_{m}P_{m}=S_{m}F_{N}.\,} == The generalized Fourier-slice theorem == In addition to generalizing to N dimensions, the projection-slice theorem can be further generalized with an arbitrary change of basis. For convenience of notation, we consider the change of basis to be represented as B, an N-by-N invertible matrix operating on N-dimensional column vectors. Then the generalized Fourier-slice theorem can be stated as F m P m B = S m B − T | B − T | F N {\displaystyle F_{m}P_{m}B=S_{m}{\frac {B^{-T}}{|B^{-T}|}}F_{N}} where B − T = ( B − 1 ) T {\displaystyle B^{-T}=(B^{-1})^{T}} is the transpose of the inverse of the change of basis transform. == Proof in two dimensions == The projection-slice theorem is easily proven for the case of two dimensions. Without loss of generality, we can take the projection line to be the x-axis. There is no loss of generality because if we use a shifted and rotated line, the law still applies. Using a shifted line (in y) gives the same projection and therefore the same 1D Fourier transform results. The rotated function is the Fourier pair of the rotated Fourier transform, for which the theorem again holds. If f(x, y) is a two-dimensional function, then the projection of f(x, y) onto the x axis is p(x) where p ( x ) = ∫ − ∞ ∞ f ( x , y ) d y . {\displaystyle p(x)=\int _{-\infty }^{\infty }f(x,y)\,dy.} The Fourier transform of f ( x , y ) {\displaystyle f(x,y)} is F ( k x , k y ) = ∫ − ∞ ∞ ∫ − ∞ ∞ f ( x , y ) e − 2 π i ( x k x + y k y ) d x d y . {\displaystyle F(k_{x},k_{y})=\int _{-\infty }^{\infty }\int _{-\infty }^{\infty }f(x,y)\,e^{-2\pi i(xk_{x}+yk_{y})}\,dxdy.} The slice is then s ( k x ) {\displaystyle s(k_{x})} s ( k x ) = F ( k x , 0 ) = ∫ − ∞ ∞ ∫ − ∞ ∞ f ( x , y ) e − 2 π i x k x d x d y {\displaystyle s(k_{x})=F(k_{x},0)=\int _{-\infty }^{\infty }\int _{-\infty }^{\infty }f(x,y)\,e^{-2\pi ixk_{x}}\,dxdy} = ∫ − ∞ ∞ [ ∫ − ∞ ∞ f ( x , y ) d y ] e − 2 π i x k x d x {\displaystyle =\int _{-\infty }^{\infty }\left[\int _{-\infty }^{\infty }f(x,y)\,dy\right]\,e^{-2\pi ixk_{x}}dx} = ∫ − ∞ ∞ p ( x ) e − 2 π i x k x d x {\displaystyle =\int _{-\infty }^{\infty }p(x)\,e^{-2\pi ixk_{x}}dx} which is just the Fourier transform of p(x). The proof for higher dimensions is easily generalized from the above example. == The FHA cycle == If the two-dimensional function f(r) is circularly symmetric, it may be represented as f(r), where r = |r|. In this case the projection onto any projection line will be the Abel transform of f(r). The two-dimensional Fourier transform of f(r) will be a circularly symmetric function given by the zeroth-order Hankel transform of f(r), which will therefore also represent any slice through the origin. The projection-slice theorem then states that the Fourier transform of the projection equals the slice or F 1 A 1 = H , {\displaystyle F_{1}A_{1}=H,} where A1 represents the Abel-transform operator, projecting a two-dimensional circularly symmetric function onto a one-dimensional line, F1 represents the 1-D Fourier-transform operator, and H represents the zeroth-order Hankel-transform operator. == Extension to fan beam or cone-beam CT == The projection-slice theorem is suitable for CT image reconstruction with parallel beam projections. It does not directly apply to fanbeam or conebeam CT. The theorem was extended to fan-beam and conebeam CT image reconstruction by Shuang-ren Zhao in 1995.

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  • Deconvolution

    Deconvolution

    In mathematics, deconvolution is the inverse of convolution. Both operations are used in signal processing and image processing. For example, it may be possible to recover the original signal after a filter (convolution) by using a deconvolution method with a certain degree of accuracy. Due to the measurement error of the recorded signal or image, it can be demonstrated that the worse the signal-to-noise ratio (SNR), the worse the reversing of a filter will be; hence, inverting a filter is not always a good solution as the error amplifies. Deconvolution offers a solution to this problem. The foundations for deconvolution and time-series analysis were largely laid by Norbert Wiener of the Massachusetts Institute of Technology in his book Extrapolation, Interpolation, and Smoothing of Stationary Time Series (1949). The book was based on work Wiener had done during World War II but that had been classified at the time. Some of the early attempts to apply these theories were in the fields of weather forecasting and economics. == Description == In general, the objective of deconvolution is to find the solution f of a convolution equation of the form: f ∗ g = h {\displaystyle fg=h\,} Usually, h is some recorded signal, and f is some signal that we wish to recover, but has been convolved with a filter or distortion function g, before we recorded it. Usually, h is a distorted version of f and the shape of f can't be easily recognized by the eye or simpler time-domain operations. The function g represents the impulse response of an instrument or a driving force that was applied to a physical system. If we know g, or at least know the form of g, then we can perform deterministic deconvolution. However, if we do not know g in advance, then we need to estimate it. This can be done using methods of statistical estimation or building the physical principles of the underlying system, such as the electrical circuit equations or diffusion equations. There are several deconvolution techniques, depending on the choice of the measurement error and deconvolution parameters: === Raw deconvolution === When the measurement error is very low (ideal case), deconvolution collapses into a filter reversing. This kind of deconvolution can be performed in the Laplace domain. By computing the Fourier transform of the recorded signal h and the system response function g, you get H and G, with G as the transfer function. Using the convolution theorem, F = H / G {\displaystyle F=H/G\,} where F is the estimated Fourier transform of f. Finally, the inverse Fourier transform of the function F is taken to find the estimated deconvolved signal f. Note that G is at the denominator and could amplify elements of the error model if present. === Deconvolution with noise === In physical measurements, the situation is usually closer to ( f ∗ g ) + ε = h {\displaystyle (fg)+\varepsilon =h\,} In this case ε is noise that has entered our recorded signal. If a noisy signal or image is assumed to be noiseless, the statistical estimate of g will be incorrect. In turn, the estimate of ƒ will also be incorrect. The lower the signal-to-noise ratio, the worse the estimate of the deconvolved signal will be. That is the reason why inverse filtering the signal (as in the "raw deconvolution" above) is usually not a good solution. However, if at least some knowledge exists of the type of noise in the data (for example, white noise), the estimate of ƒ can be improved through techniques such as Wiener deconvolution. == Applications == === Seismology === The concept of deconvolution had an early application in reflection seismology. In 1950, Enders Robinson was a graduate student at MIT. He worked with others at MIT, such as Norbert Wiener, Norman Levinson, and economist Paul Samuelson, to develop the "convolutional model" of a reflection seismogram. This model assumes that the recorded seismogram s(t) is the convolution of an Earth-reflectivity function e(t) and a seismic wavelet w(t) from a point source, where t represents recording time. Thus, our convolution equation is s ( t ) = ( e ∗ w ) ( t ) . {\displaystyle s(t)=(ew)(t).\,} The seismologist is interested in e, which contains information about the Earth's structure. By the convolution theorem, this equation may be Fourier transformed to S ( ω ) = E ( ω ) W ( ω ) {\displaystyle S(\omega )=E(\omega )W(\omega )\,} in the frequency domain, where ω {\displaystyle \omega } is the frequency variable. By assuming that the reflectivity is white, we can assume that the power spectrum of the reflectivity is constant, and that the power spectrum of the seismogram is the spectrum of the wavelet multiplied by that constant. Thus, | S ( ω ) | ≈ k | W ( ω ) | . {\displaystyle |S(\omega )|\approx k|W(\omega )|.\,} If we assume that the wavelet is minimum phase, we can recover it by calculating the minimum phase equivalent of the power spectrum we just found. The reflectivity may be recovered by designing and applying a Wiener filter that shapes the estimated wavelet to a Dirac delta function (i.e., a spike). The result may be seen as a series of scaled, shifted delta functions (although this is not mathematically rigorous): e ( t ) = ∑ i = 1 N r i δ ( t − τ i ) , {\displaystyle e(t)=\sum _{i=1}^{N}r_{i}\delta (t-\tau _{i}),} where N is the number of reflection events, r i {\displaystyle r_{i}} are the reflection coefficients, t − τ i {\displaystyle t-\tau _{i}} are the reflection times of each event, and δ {\displaystyle \delta } is the Dirac delta function. In practice, since we are dealing with noisy, finite bandwidth, finite length, discretely sampled datasets, the above procedure only yields an approximation of the filter required to deconvolve the data. However, by formulating the problem as the solution of a Toeplitz matrix and using Levinson recursion, we can relatively quickly estimate a filter with the smallest mean squared error possible. We can also do deconvolution directly in the frequency domain and get similar results. The technique is closely related to linear prediction. === Optics and other imaging === In optics and imaging, the term "deconvolution" is specifically used to refer to the process of reversing the optical distortion that takes place in an optical microscope, electron microscope, telescope, or other imaging instrument, thus creating clearer images. It is usually done in the digital domain by a software algorithm, as part of a suite of microscope image processing techniques. Deconvolution is also practical to sharpen images that suffer from fast motion or jiggles during capturing. Early Hubble Space Telescope images were distorted by a flawed mirror and were sharpened by deconvolution. The usual method is to assume that the optical path through the instrument is optically perfect, convolved with a point spread function (PSF), that is, a mathematical function that describes the distortion in terms of the pathway a theoretical point source of light (or other waves) takes through the instrument. Usually, such a point source contributes a small area of fuzziness to the final image. If this function can be determined, it is then a matter of computing its inverse or complementary function, and convolving the acquired image with that. The result is the original, undistorted image. In practice, finding the true PSF is impossible, and usually an approximation of it is used, theoretically calculated or based on some experimental estimation by using known probes. Real optics may also have different PSFs at different focal and spatial locations, and the PSF may be non-linear. The accuracy of the approximation of the PSF will dictate the final result. Different algorithms can be employed to give better results, at the price of being more computationally intensive. Since the original convolution discards data, some algorithms use additional data acquired at nearby focal points to make up some of the lost information. Regularization in iterative algorithms (as in expectation-maximization algorithms) can be applied to avoid unrealistic solutions. When the PSF is unknown, it may be possible to deduce it by systematically trying different possible PSFs and assessing whether the image has improved. This procedure is called blind deconvolution. Blind deconvolution is a well-established image restoration technique in astronomy, where the point nature of the objects photographed exposes the PSF thus making it more feasible. It is also used in fluorescence microscopy for image restoration, and in fluorescence spectral imaging for spectral separation of multiple unknown fluorophores. The most common iterative algorithm for the purpose is the Richardson–Lucy deconvolution algorithm; the Wiener deconvolution (and approximations) are the most common non-iterative algorithms. For some specific imaging systems such as laser pulsed terahertz systems, PSF can be modeled mathematically. As a result, as shown in the figure, deconvolution of the modeled PS

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  • Outline of brain mapping

    Outline of brain mapping

    The following outline is provided as an overview of and topical guide to brain mapping: Brain mapping – set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. Brain mapping is further defined as the study of the anatomy and function of the brain and spinal cord through the use of imaging (including intra-operative, microscopic, endoscopic and multi-modality imaging), immunohistochemistry, molecular and optogenetics, stem cell and cellular biology, engineering (material, electrical and biomedical), neurophysiology and nanotechnology. == Broad scope == History of neuroscience History of neurology Brain mapping Human brain Neuroscience Nervous system. === The neuron doctrine === Neuron doctrine – A set of carefully constructed elementary set of observations regarding neurons. For more granularity, more current, and more advanced topics, see the cellular level section Asserts that neurons fall under the broader cell theory, which postulates: All living organisms are composed of one or more cells. The cell is the basic unit of structure, function, and organization in all organisms. All cells come from preexisting, living cells. The Neuron doctrine postulates several elementary aspects of neurons: The brain is made up of individual cells (neurons) that contain specialized features such as dendrites, a cell body, and an axon. Neurons are cells differentiable from other tissues in the body. Neurons differ in size, shape, and structure according to their location or functional specialization. Every neuron has a nucleus, which is the trophic center of the cell (The part which must have access to nutrition). If the cell is divided, only the portion containing the nucleus will survive. Nerve fibers are the result of cell processes and the outgrowths of nerve cells. (Several axons are bound together to form one nerve fibril. See also: Neurofilament. Several nerve fibrils then form one large nerve fiber. Myelin, an electrical insulator, forms around selected axons. Neurons are generated by cell division. Neurons are connected by sites of contact and not via cytoplasmic continuity. (A cell membrane isolates the inside of the cell from its environment. Neurons do not communicate via direct cytoplasm to cytoplasm contact.) Law of dynamic polarization. Although the axon can conduct in both directions, in tissue there is a preferred direction of transmission from cell to cell. Elements added later to the initial Neuron doctrine A barrier to transmission exists at the site of contact between two neurons that may permit transmission. (Synapse) Unity of transmission. If a contact is made between two cells, then that contact can be either excitatory or inhibitory, but will always be of the same type. Dale's law, each nerve terminal releases a single type of neurotransmitter. Some of the basic postulates in the Neuron doctrine have been subsequently questioned, refuted, or updated. See the cellular level section topics for additional information. === Map, atlas, and database projects === Brain Activity Map Project – 2013 NIH $3 billion project to map every neuron in the human brain in ten years, based upon the Human Genome Project. NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative [1] Community outreach site for above where the public may comment [2] Human Brain Project (EU) – 1 billion euro, 10-year project to simulate the human brain with supercomputers. BigBrain A high-resolution 3D atlas of the human brain created as part of the HBP. Human Connectome Project – 2009 NIH $30 million project to build a network map of the human brain, including structural (anatomical) and functional elements. Emphasis included research into dyslexia, autism, Alzheimer's disease, and schizophrenia. See also Connectome a, comprehensive map of neural connections in the brain. Allen Brain Atlas – 2003 $100 million project funded by Paul Allen (Microsoft) BrainMaps – National Institute of Health (NIH) database including 60 terabytes of image scans of primate and non-primates, integrated with information covering structure and function. NeuroNames – Defines the brain in terms of about 550 primary structures (about 850 unique structures) to which all other structures, names, and synonyms are related. About 15,000 neuroanatomical terms are cross indexed, including many synonyms in seven languages. Coverage includes the brain and spinal cord of the four species most frequently studied by neuroscientists: human, macaque (monkey), rat and mouse. The controlled, standardized vocabulary for each structure is located in an unambiguous, strict physical hierarchy, and these terms are selected based on ease of pronunciation, mnemonic value, and frequency of use in recent neuroscientific publications. Relation of each structure to its superstructures and substructures is included. The controlled vocabulary is suitable for uniquely indexing neuroanatomical information in digital databases. Decade of the Brain 1990–1999 promotion by NIH and the Library of Congress "to enhance public awareness of the benefits to be derived from brain research". Communications targeted Members of Congress, staffs, and the general public to promote funding. Talairach Atlas see Jean Talairach Harvard Whole Brain Atlas see Human brain MNI Template see Medical image computing Blue Brain Project and Artificial brain International Consortium for Brain Mapping see Brain Mapping List of neuroscience databases NIH Toolbox National Institute of Health (USA) toolbox for the assessment of neurological and behavioral function Organization for Human Brain Mapping The Organization for Human Brain Mapping (OHBM) is an international society dedicated to using neuroimaging to discover the organization of the human brain. == Imaging and recording systems == This section covers imaging and recording systems. The general section covers history, neuroimaging, and techniques for mapping specific neural connections. The specific systems section covers the various specific technologies, including experimental and widely deployed imaging and recording systems. === General === Most imaging work to date on individual neurons has been conducted outside the brain, typically on large neurons, and has been most frequently destructive. New techniques are however rapidly emerging. Search on "Single neuron imaging" and see related topics: Biological neuron model, Single-unit recording, Neural oscillation, Computational neuroscience. dMRI (above) is also promising in non-destructive imaging of single neurons inside the brain. History of neuroimaging (redirects from Brain scanner) Neuroimaging (redirects from Brain function map) Connectomics – mapping technique showing neural connections in a nervous system. === Specific systems === Cortical stimulation mapping Diffusion MRI (dMRI) – includes diffusion tensor imaging (DTI) and diffusion functional MRI (DfMRI). dMRI is a recent breakthrough in brain mapping allowing the visualization of cross connections between different anatomical parts of the brain. It allows noninvasive imaging of white matter fiber structure and in addition to mapping can be useful in clinical observations of abnormalities, including damage from stroke. Electroencephalography (EEG) – uses electrodes on the scalp and other techniques to detect the electrical flow of currents. Electrocorticography – intracranial EEG, the practice of using electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. Electrophysiological techniques for clinical diagnosis Functional magnetic resonance imaging (fMRI) Medical image computing (brain research of leads medical and surgical uses of mapping technology) Neurostimulation (in research stimulation is frequently used in conjunction with imaging) Positron emission tomography (PET) – a nuclear medical imaging technique that produces a three-dimensional image or picture of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule. Three-dimensional images of tracer concentration within the body are then constructed by computer analysis. In modern scanners, three dimensional imaging is often accomplished with the aid of a CT X-ray scan performed on the patient during the same session, in the same machine. === Imaging and recording componentry === ==== Electrochemical ==== Haemodynamic response – the rapid delivery of blood to active neuronal tissues. Blood Oxygenation Level Dependent signal (BOLD), corresponds to the concentration of deoxyhemoglobin. The BOLD effect is based on the fact that when neuronal activity is increased in one part of the brain, there is also an increased amount of cerebral blood flow to that area. Functional m

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