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  • Prosthesis

    Prosthesis

    In medicine, a prosthesis (pl.: prostheses; from Ancient Greek: πρόσθεσις, romanized: prósthesis, lit. 'addition, application, attachment'), or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through physical trauma, disease, or a condition present at birth (congenital disorder). Prostheses may restore the normal functions of the missing body part, or may perform a cosmetic function. A person who has undergone an amputation is sometimes referred to as an amputee, Rehabilitation for someone with an amputation is primarily coordinated by a physiatrist as part of an inter-disciplinary team consisting of physiatrists, prosthetists, nurses, physical therapists, and occupational therapists. Prostheses can be created by hand or with computer-aided design (CAD), a software interface that helps creators design and analyze the creation with computer-generated 2-D and 3-D graphics as well as analysis and optimization tools. == Types == A person's prosthetic device should be designed and assembled to meet their individual appearance and functional needs. Depending on personal circumstances, co-morbidities, budget or health insurance coverage, and access to medical care, decisions may need to balance aesthetics and function. In addition, for some individuals, a myoelectric device, a body-powered device, or an activity-specific device may be appropriate options. The person's future goals and vocational aspirations and potential capabilities may help them choose between one or more devices. Craniofacial prostheses include intra-oral and extra-oral prostheses. Extra-oral prostheses are further divided into hemifacial, auricular (ear), nasal, orbital and ocular. Intra-oral prostheses include dental prostheses, such as dentures, obturators, and dental implants. Prostheses of the neck include larynx substitutes, trachea and upper esophageal replacements, Some prostheses of the torso include breast prostheses which may be either single or bilateral, full breast devices or nipple prostheses. Penile prostheses are used to treat erectile dysfunction, perform phalloplasty procedures in men, and to build a new penis in female-to-male gender reassignment surgeries. === Limb prostheses === Limb prostheses include both upper- and lower-extremity prostheses. Upper-extremity prostheses are used at varying levels of amputation: forequarter, shoulder disarticulation, transhumeral prosthesis, elbow disarticulation, transradial prosthesis, wrist disarticulation, full hand, partial hand, finger, partial finger. A transradial prosthesis is an artificial limb that replaces an arm missing below the elbow. Upper limb prostheses can be categorized in three main categories: Passive devices, Body Powered devices, and Externally Powered (myoelectric) devices. Passive devices can either be passive hands, mainly used for cosmetic purposes, or passive tools, mainly used for specific activities (e.g. leisure or vocational). An extensive overview and classification of passive devices can be found in a literature review by Maat et.al. A passive device can be static, meaning the device has no movable parts, or it can be adjustable, meaning its configuration can be adjusted (e.g. adjustable hand opening). Despite the absence of active grasping, passive devices are very useful in bimanual tasks that require fixation or support of an object, or for gesticulation in social interaction. According to scientific data a third of the upper limb amputees worldwide use a passive prosthetic hand. Body Powered or cable-operated limbs work by attaching a harness and cable around the opposite shoulder of the damaged arm. A recent body-powered approach has explored the utilization of the user's breathing to power and control the prosthetic hand to help eliminate actuation cable and harness. The third category of available prosthetic devices comprises myoelectric arms. This particular class of devices distinguishes itself from the previous ones due to the inclusion of a battery system. This battery serves the dual purpose of providing energy for both actuation and sensing components. While actuation predominantly relies on motor or pneumatic systems, a variety of solutions have been explored for capturing muscle activity, including techniques such as Electromyography, Sonomyography, Myokinetic, and others. These methods function by detecting the minute electrical currents generated by contracted muscles during upper arm movement, typically employing electrodes or other suitable tools. Subsequently, these acquired signals are converted into gripping patterns or postures that the artificial hand will then execute. In the prosthetics industry, a trans-radial prosthetic arm is often referred to as a "BE" or below elbow prosthesis. Lower-extremity prostheses provide replacements at varying levels of amputation. These include hip disarticulation, transfemoral prosthesis, knee disarticulation, transtibial prosthesis, Syme's amputation, foot, partial foot, and toe. The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency) and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency). A transfemoral prosthesis is an artificial limb that replaces a leg missing above the knee. Transfemoral amputees can have a very difficult time regaining normal movement. In general, a transfemoral amputee must use approximately 80% more energy to walk than a person with two whole legs. This is due to the complexities in movement associated with the knee. In newer and more improved designs, hydraulics, carbon fiber, mechanical linkages, motors, computer microprocessors, and innovative combinations of these technologies are employed to give more control to the user. In the prosthetics industry, a trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis. A transtibial prosthesis is an artificial limb that replaces a leg missing below the knee. A transtibial amputee is usually able to regain normal movement more readily than someone with a transfemoral amputation, due in large part to retaining the knee, which allows for easier movement. Lower extremity prosthetics describe artificially replaced limbs located at the hip level or lower. In the prosthetics industry, a transtibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis. Prostheses are manufactured and fit by clinical prosthetists. Prosthetists are healthcare professionals responsible for making, fitting, and adjusting prostheses and for lower limb prostheses will assess both gait and prosthetic alignment. Once a prosthesis has been fit and adjusted by a prosthetist, a rehabilitation physiotherapist (called physical therapist in America) will help teach a new prosthetic user to walk with a leg prosthesis. To do so, the physical therapist may provide verbal instructions and may also help guide the person using touch or tactile cues. This may be done in a clinic or home. There is some research suggesting that such training in the home may be more successful if the treatment includes the use of a treadmill. Using a treadmill, along with the physical therapy treatment, helps the person to experience many of the challenges of walking with a prosthesis. In the United Kingdom, 75% of lower limb amputations are performed due to inadequate circulation (dysvascularity). This condition is often associated with many other medical conditions (co-morbidities) including diabetes and heart disease that may make it a challenge to recover and use a prosthetic limb to regain mobility and independence. For people who have inadequate circulation and have lost a lower limb, there is insufficient evidence due to a lack of research, to inform them regarding their choice of prosthetic rehabilitation approaches. Lower extremity prostheses are often categorized by the level of amputation or after the name of a surgeon: Transfemoral (Above-knee) Transtibial (Below-knee) Ankle disarticulation (more commonly known as Syme's amputation) Knee disarticulation (also see knee replacement) Hip disarticulation, (also see hip replacement) Hemi-pelvictomy Partial foot amputations (Pirogoff, Talo-Navicular and Calcaneo-cuboid (Chopart), Tarso-metatarsal (Lisfranc), Trans-metatarsal, Metatarsal-phalangeal, Ray amputations, toe amputations). Van Nes rotationplasty ==== Prosthetic raw materials ==== Prosthetic are made lightweight for better convenience for the amputee. Some of these materials include: Plastics: Polyethylene Polypropylene Acrylics Polyurethane Wood (early prosthetics) Rubber (early prosthetics) Lightweight metals: Aluminum Composites: Carbon fiber reinforced polymers Wheeled prostheses have also been used extensively in the rehabilitation of injured domestic animals, including dogs, cats, pigs, rabbits, and

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  • DREAM Challenges

    DREAM Challenges

    DREAM Challenges (Dialogue for Reverse Engineering Assessment and Methods) is a non-profit initiative for advancing biomedical and systems biology research via crowd-sourced competitions. Started in 2006, DREAM challenges collaborate with Sage Bionetworks to provide a platform for competitions run on the Synapse platform. Over 60 DREAM challenges have been conducted over the span of over 15 years. == Overview == DREAM Challenges were founded in 2006 by Gustavo Stolovizky from IBM Research and Andrea Califano from Columbia University. Current chair of the DREAM organization is Paul Boutros from University of California. Further organization spans emeritus chairs Justin Guinney and Gustavo Stolovizky, and multiple DREAM directors. Individual challenges focus on tackling a specific biomedical research question, typically narrowed down to a specific disease. A prominent disease focus has been on oncology, with multiple past challenges focused on breast cancer, acute myeloid leukemia, and prostate cancer or similar diseases. The data involved in an individual challenge reflects the disease context; while cancers typically involve data such as mutations in the human genome, gene expression and gene networks in transcriptomics, and large scale proteomics, newer challenges have shifted towards single cell sequencing technologies as well as emerging gut microbiome related research questions, thus reflecting trends in the wider research community. Motivation for DREAM Challenges is that via crowd-sourcing data to a larger audience via competitions, better models and insight is gained than if the analysis was conducted by a single entity. Past competitions have been published in such scientific venues as the flagship journals of the Nature Portfolio and PLOS publishing groups. Results of DREAM challenges are announced via web platforms, and the top performing participants are invited to present their results in the annual RECOMB/ISCB Conferences with RSG/DREAM organized by the ISCB. While DREAM Challenges have emphasized open science and data, in order to mitigate issues rising from highly sensitive data such as genomics in patient cohorts, "model to data" approaches have been adopted. In such challenges participants submit their models via containers such as Docker or Singularity. This allows retaining confidentiality of the original data as these containers are then run by the organizers on the confidential data. This differs from the more traditional open data model, where participants submit predictions directly based on the provided open data. == Challenge organization == DREAM challenge comprises a core DREAM/Sage Bionetworks organization group as well as an extended scientific expert group, who may have contributed to creation and conception of the challenge or by providing key data. Additionally, new DREAM challenges may be proposed by the wider research community. Pharmaceutical companies or other private entities may also be involved in DREAM challenges, for example in providing data. == Challenge structure == Timelines for key stages (such as introduction webinars, model submission deadlines, and final deadline for participation) are provided in advance. After the winners are announced, organizers start collaborating with the top performing participants to conduct post hoc analyses for a publication describing key findings from the competition. Challenges may be split into sub-challenges, each addressing a different subtopic within the research question. For example, regarding cancer treatment efficacy predictions, these may be separate predictions for progression-free survival, overall survival, best overall response according to RECIST, or exact time until event (progression or death). == Participation == During DREAM challenges, participants typically build models on provided data, and submit predictions or models that are then validated on held-out data by the organizers. While DREAM challenges avoid leaking validation data to participants, there are typically mid-challenge submission leaderboards available to assist participants in evaluating their performance on a sub-sampled or scrambled dataset. DREAM challenges are free for participants. During the open phase anybody can register via Synapse to participate either individually or as a team. A person may only register once and may not use any aliases. There are some exceptions, which disqualify an individual from participating, for example: Person has privileged access to the data for the particular challenge, thus providing them with an unfair advantage. Person has been caught or is under suspicion of cheating or abusing previous DREAM Challenges. Person is a minor (under age 18 or the age of majority in jurisdiction of residence). This may be alleviated via parental consent.

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  • Andrej Karpathy

    Andrej Karpathy

    Andrej Karpathy (born 23 October 1986) is a Slovak-Canadian AI researcher, who co-founded and formerly worked at OpenAI, where he specialized in deep learning and computer vision. He also worked as the director of artificial intelligence and Autopilot Vision at Tesla, and in 2024 he founded Eureka Labs, an AI education platform. In 2026 he joined Anthropic as part of the pretraining team. == Education and early life == Karpathy was born in Bratislava, Czechoslovakia (now Slovakia), and moved with his family to Toronto when he was 15. He completed his Computer Science and Physics bachelor's degrees at University of Toronto in 2009 and his master's degree at University of British Columbia in 2011, where he worked on physically simulated figures (for example, a simulated runner or a simulated person in a crowd) with his adviser Michiel van de Panne. In 2006, Karpathy began posting videos on YouTube on his channel, badmephisto. He garnered fame by posting Rubik's cube tutorials which have been used by famous speedcubers such as Feliks Zemdegs. The channel has over 9 million views as of June 2025. Karpathy received a PhD from Stanford University in 2015 under the supervision of Fei-Fei Li, focusing on the intersection of natural language processing and computer vision, and deep learning models suited for this task. == Career and research == He authored and was the primary instructor of the first deep learning course at Stanford, CS 231n: Convolutional Neural Networks for Visual Recognition. The course became one of the largest classes at Stanford, growing from 150 students in 2015 to 750 in 2017. Karpathy is a founding member of the artificial intelligence research group OpenAI, where he was a research scientist from 2015 to 2017. In June 2017 he became Tesla's director of artificial intelligence and reported to Elon Musk. He was named one of MIT Technology Review's Innovators Under 35 for 2020. After taking a several-months-long sabbatical from Tesla, he announced he was leaving the company in July 2022. As of February 2023, he makes YouTube videos on how to create artificial neural networks. On February 9, 2023, Karpathy announced he was returning to OpenAI. A year later on February 13, 2024, an OpenAI spokesperson confirmed that Karpathy had left OpenAI. In the same year, he was named one of Time Magazine's 100 Most Influential People in AI. On July 16, 2024, Karpathy announced on his X account that he started a new AI education company called Eureka Labs. Their first product was the AI course, LLM101n. He also has a broader educational effort, the "Zero to Hero" series on LLM fundamentals. The company also advocates for AI teaching assistants, a concept which has been criticized due to data privacy concerns and the removal of personal connection between teacher and student. In February 2025, Karpathy coined the term vibe coding to describe how AI tools allow hobbyists to construct apps and websites just by typing prompts. On May 19, 2026, he announced that he joined Anthropic via a statement on X, while the company stated that he will be leading a team for research in pretraining.

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  • Geoffrey Hinton

    Geoffrey Hinton

    Geoffrey Everest Hinton (born 6 December 1947) is a British-Canadian computer scientist, cognitive scientist, cognitive psychologist and Nobel Prize laureate known for his work on artificial neural networks, which earned him the title "the Godfather of AI". He is University Professor Emeritus at the University of Toronto. From 2013 to 2023, he divided his time working for Google Brain and the University of Toronto before publicly announcing his departure from Google in May 2023, citing concerns about the many risks of artificial intelligence (AI) technology. In 2017, he co-founded and became the chief scientific advisor of the Vector Institute in Toronto. With David Rumelhart and Ronald J. Williams, Hinton was co-author of a highly cited paper published in 1986 that popularised the backpropagation algorithm for training multi-layer neural networks, although they were not the first to propose the approach. Hinton is viewed as a leading figure in the deep learning community. The image-recognition milestone of the AlexNet designed in collaboration with his students Alex Krizhevsky and Ilya Sutskever for the ImageNet challenge 2012 was a breakthrough in the field of computer vision. Hinton received the 2018 Turing Award, together with Yoshua Bengio and Yann LeCun for their work on deep learning. They are sometimes referred to as the "Godfathers of Deep Learning" and have continued to give public talks together. He was also awarded, along with John Hopfield, the 2024 Nobel Prize in Physics for "foundational discoveries and inventions that enable machine learning with artificial neural networks". In May 2023, Hinton announced his resignation from Google to be able to "freely speak out about the risks of AI". He has voiced concerns about deliberate misuse by malicious actors, technological unemployment, and existential risk from artificial general intelligence. He noted that establishing safety guidelines will require cooperation among those competing in use of AI in order to avoid the worst outcomes. After receiving the Nobel Prize, he called for urgent research into AI safety to figure out how to control AI systems smarter than humans. == Education == Hinton was born on 6 December 1947 in Wimbledon in the United Kingdom and was educated at Clifton College in Bristol. In 1967, he matriculated as an undergraduate student at King's College, Cambridge and, after switching between different fields such as natural sciences, history of art, and philosophy, eventually graduated with a Bachelor of Arts in experimental psychology in 1970. He spent a year apprenticing carpentry before returning to academic studies. From 1972 to 1975, he continued his study at the University of Edinburgh, where he was awarded a PhD in artificial intelligence in 1978 for research supervised by Christopher Longuet-Higgins, who favored the symbolic AI approach over the neural network approach. == Career == After his PhD, Hinton initially worked at the University of Sussex and at the MRC Applied Psychology Unit. After having difficulty getting funding in Britain, he worked in the US at the University of California, San Diego, and Carnegie Mellon University. He was the founding director of the Gatsby Charitable Foundation Computational Neuroscience Unit at University College London. He is currently University Professor Emeritus in the Department of Computer Science at the University of Toronto, where he has been affiliated since 1987. Upon arrival in Canada, Geoffrey Hinton was appointed at the Canadian Institute for Advanced Research (CIFAR) in 1987 as a Fellow in CIFAR's first research program, Artificial Intelligence, Robotics & Society. In 2004, Hinton and collaborators successfully proposed the launch of a new program at CIFAR, "Neural Computation and Adaptive Perception" (NCAP), which today is named "Learning in Machines & Brains". Hinton would go on to lead NCAP for ten years. Among the members of the program are Yoshua Bengio and Yann LeCun, with whom Hinton would go on to win the ACM A.M. Turing Award in 2018. All three Turing winners continue to be members of the CIFAR Learning in Machines & Brains program. Hinton taught a free online course on Neural Networks on the education platform Coursera in 2012. He co-founded DNNresearch Inc. in 2012 with his two graduate students, Alex Krizhevsky and Ilya Sutskever, at the University of Toronto's department of computer science. In March 2013, Google acquired DNNresearch Inc. for $44 million, and Hinton planned to "divide his time between his university research and his work at Google". In May 2023, Hinton publicly announced his resignation from Google. He explained his decision, saying he wanted to "freely speak out about the risks of AI" and added that part of him now regrets his life's work. Notable former PhD students and postdoctoral researchers from his group include Peter Dayan, Sam Roweis, Max Welling, Richard Zemel, Brendan Frey, Radford M. Neal, Yee Whye Teh, Ruslan Salakhutdinov, Ilya Sutskever, Yann LeCun, Alex Graves, Zoubin Ghahramani, and Peter Fitzhugh Brown. == Research == Hinton's research concerns the use of neural networks for machine learning, memory, perception, and symbol processing. He has written or co-written more than 200 peer-reviewed publications. In the 1980s, Hinton was part of the "Parallel Distributed Processing" group at Carnegie Mellon University, which included notable scientists like Terrence Sejnowski, Francis Crick, David Rumelhart, and James McClelland. This group favoured the connectionist approach during the AI winter. Their findings were published in a two-volume set. The connectionist approach adopted by Hinton suggests that capabilities in areas like logic and grammar can be encoded into the parameters of neural networks, and that neural networks can learn them from data. Symbolists on the other side advocated for explicitly programming knowledge and rules into AI systems. In 1985, Hinton co-invented Boltzmann machines with David Ackley and Terry Sejnowski. His other contributions to neural network research include distributed representations, time delay neural network, mixtures of experts, Helmholtz machines and product of experts. An accessible introduction to Geoffrey Hinton's research can be found in his articles in Scientific American in September 1992 and October 1993. In 1995, Hinton and colleagues proposed the wake-sleep algorithm, involving a neural network with separate pathways for recognition and generation, being trained with alternating "wake" and "sleep" phases. In 2007, Hinton coauthored an unsupervised learning paper titled Unsupervised learning of image transformations. In 2008, he developed the visualization method t-SNE with Laurens van der Maaten.While Hinton was a postdoc at UC San Diego, David Rumelhart, Hinton and Ronald J. Williams applied the backpropagation algorithm to multi-layer neural networks. Their experiments showed that such networks can learn useful internal representations of data. In a 2018 interview, Hinton said that "David Rumelhart came up with the basic idea of backpropagation, so it's his invention." Although this work was important in popularising backpropagation, it was not the first to suggest the approach. Reverse-mode automatic differentiation, of which backpropagation is a special case, was proposed by Seppo Linnainmaa in 1970, and Paul Werbos proposed to use it to train neural networks in 1974. In 2017, Hinton co-authored two open-access research papers about capsule neural networks, extending the concept of "capsule" introduced by Hinton in 2011. The architecture aims to better model part-whole relationships within objects in visual data. In 2021, Hinton presented GLOM, a speculative architecture idea also aiming to improve image understanding by modeling part-whole relationships in neural networks. In 2021, Hinton co-authored a widely cited paper proposing a framework for contrastive learning in computer vision. The technique involves pulling together representations of augmented versions of the same image, and pushing apart dissimilar representations. At the 2022 Conference on Neural Information Processing Systems (NeurIPS), Hinton introduced a new learning algorithm for neural networks that he calls the "Forward-Forward" algorithm. The idea is to replace the traditional forward-backwards passes of backpropagation with two forward passes, one with positive (i.e. real) data and the other with negative data that could be generated solely by the network. The Forward-Forward algorithm is well-suited for what Hinton calls "mortal computation", where the knowledge learned is not transferable to other systems and thus dies with the hardware, as can be the case for certain analog computers used for machine learning. == Honours and awards == Hinton is a Fellow of the US Association for the Advancement of Artificial Intelligence (FAAAI) since 1990. He was elected a Fellow of the Royal Society of Canada (FRSC) in 1996, and then a

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  • Clubhouse (app)

    Clubhouse (app)

    Clubhouse is an American social audio app for iOS and Android developed by Alpha Exploration Co. that enables users to participate in real-time, audio-only communication within virtual "rooms". Launched in March 2020 by Paul Davison and Rohan Seth, the platform is characterized by its "drop-in" nature, where users can join live discussions on a wide range of topics as either listeners or speakers. The application gained attention in early 2021, operating on an invite-only model and featuring appearances from public figures such as Elon Musk, Oprah Winfrey, and Mark Zuckerberg. During this period, Clubhouse reached a reported valuation of approximately $4 billion and contributed to the expansion of similar social audio features like Twitter Spaces and Spotify Greenroom. The app later expanded to Android in May 2021 and removed its waitlist in July 2021, opening access to the general public. == History == Clubhouse began as an invite only social media startup by Paul Davison and Rohan Seth in Fall 2019. Originally designed for podcasts with the name Talkshow, the app was rebranded as "Clubhouse" and officially released for the iOS operating system in March 2020 and as of May 2021 the Android systems as well. Clubhouse was valued at $100 million after receiving funding from notable angel investors. These investors included Ryan Hoover (Founder, Product Hunt), Balaji Srinivasan (Former CTO, Coinbase), James Beshara (Co-Founder, Tilt.com), and several venture capitalists, including a $12 million Series A investment from the venture capital firm, Andreessen Horowitz, in May 2020. The app gained popularity in the early months of the COVID-19 pandemic. It had 600,000 registered users by December 2020. In January 2021, CEO Paul Davison announced that the active weekly user base on the app consisted of approximately 2 million individuals. The company announced that it would start working on an Android version of the app. In that month, the app became widely used in Germany when German podcast hosts Philipp Klöckner and Philipp Gloeckler began an invite-chain over a Telegram group. It brought German influencers, journalists, and politicians to the platform. Clubhouse raised their Series B at a $1 billion valuation. On February 1, 2021, Clubhouse had an estimated 3.5 million downloads on a global level which grew rapidly to 8.1 million downloads by February 15. This significant growth in popularity was because celebrities such as Elon Musk and Mark Zuckerberg made appearances on the app. In the same month, Clubhouse hired an Android Software Developer. A year after the app's release, the number of weekly active users was greater than 10 million, but the user base declined 21% during three weeks from late February to early March. This decline was reportedly caused by a decrease in the number of Clubhouse users after its initial release. During its initial roll out, the app was accessible only by invitation, and invitation codes on eBay were selling at up to $400. On April 5, 2021, Clubhouse partnered with Stripe to launch its first monetizing feature called Clubhouse Payments. Although testing began with only 1,000 users, after a week, the company rolled out the functionality to another 60,000 or more users in the US. In the same month, Twitter entered in discussions to purchase Clubhouse for $4 billion. The talks ended with no acquisition. Later, the company raised their Series C round of funding at a $4 billion valuation. The app also received interest in a partnership, with the National Football League announcing a content deal that month; Twitter Spaces later poached Clubhouse's exclusive NFL deal with 20 official NFL Spaces scheduled for the 2021-22 season. Finally, On May 9, 2021, Clubhouse launched a beta version of the Android app for users in the US, and on May 21, 2021, Clubhouse became available worldwide for Android users. In July 2021, Clubhouse announced a partnership with TED to offer exclusive talks. and on July 21, 2021, the company discarded its invitation system and made the application available to all, though a wait list for registration was still applied in order to manage new traffic. As of the time of the announcement, the company stated it had 10 million users on the wait list. On September 23, 2021, the company announced a new feature named "Wave". In October 2021, Clubhouse rolled out new features called "Replays and Clips". In April 2023, the company announced it was reducing its staff by half amid a "resetting" due to post-pandemic market shifts. == Features == === Rooms === The primary feature of Clubhouse is real-time virtual "rooms" in which users can communicate with each other via audio. Rooms are divided into different categories based on levels of privacy. Moderator roles are denoted by a green star that appears next to the user's name. When a user joins a room, they are initially assigned to the role of a "listener" and cannot unmute themselves. Listeners can notify the moderators of their intent to join the stage and speak by clicking on the "raise hand" icon. Users who are invited to the stage become "speakers" and can unmute themselves. Users can exit a room by tapping the "leave quietly" button or with the help of peace sign emoji. === Houses === In August 2022, Clubhouse announced a feature called Houses, an invite-based version of the rooms. === Events === A lot of conversations in Clubhouse are of spontaneous nature. However, users can schedule conversations by creating events. While scheduling an event, users can first name the event and then set the date and time at which the conversation will begin. Users can also add co-hosts to help moderate the event. Once the event has been created, it is added to the Clubhouse "bulletin". The bulletin shows upcoming scheduled events and allows users to set notifications for events by clicking the bell icon corresponding to the event. Users can access the bulletin by clicking on the calendar icon at the top of the home page. === Clubs === At the Clubhouse, clubs are user communities that regularly discuss a common interest. Many clubs are present in Clubhouse which represents a wide array of topics. Users can find clubs by name under the search tab. A club consists of three categories of users: "Admin", "Leader", and "Member". Members can create private rooms and invite more users into the club. Leaders have all the privileges of a member. Apart from that, they are authorized to create/schedule club-branded open rooms. An admin can modify club settings, add/delete users, change user privileges and create/schedule any type of room. There are three types of clubs: "Open", "By Approval", and "Closed" for membership. Any user can join an open club by pressing the "Join The Club" button on the club profile. In case of approval, users need to apply and wait for membership by clicking the "Apply To Join" button on the club profile. The admins of the respective club are privileged to accept or reject the user's request. In a closed club, membership is limited to users selected by the club admin. All users of a club will be notified when a public room within the club is created. The club creation is restricted to active users and whoever creates the club will become the club admin. Eligible users can create a club by going to their profile, press the "+" sign present in the "Member of" section. Clubs in which a user is a member are shown on their profile page. The first club to half a million members was the Human Behavior Club founded by The Digital Doctor (Dr. Sohaib Imtiaz). === Backchannel === Backchannel is the messaging function which allows users to interact individually or within a group via text. The Backchannel feature was initially leaked on June 18, 2021, in response to the launch of Spotify Greenroom. This is notable step because, until this point, Clubhouse was voice only with no way to hyperlink or message. It was entirely dependent on Instagram and Twitter for text messaging. The feature was initially leaked in the App Store, which the company says was an accident on Twitter. A month later, after multiple failed attempts, the Clubhouse Backchannel finally launched on July 14, 2021. === Explore === The homepage of Clubhouse provides access to ongoing chat rooms, which are recommended based on the people and clubs that are followed by the user. As the users tap on the magnifying glass icon, they will be redirected to the explore page. On that page, users can search for people and clubs to follow and also find conversations categorized by topics. === Clubhouse Payments === This is the direct payment service provided by the app, which allows users to send money to content creators. It includes those users who had enabled this functionality in their profile. Money can be sent from users to the creator by clicking on their profile. Press "Send Money" then enter the amount you want to send. When a user does this for the first time, they'll be prompted to reg

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  • Sentential decision diagram

    Sentential decision diagram

    In artificial intelligence, a sentential decision diagram (SDD) is a type of knowledge representation used in knowledge compilation to represent Boolean functions. SDDs can be viewed as a generalization of the influential ordered binary decision diagram (OBDD) representation, by allowing decisions on multiple variables at once. Like OBDDs, SDDs allow for tractable Boolean operations, while being exponentially more succinct. For this reason, they have become an important representation in knowledge compilation. == Properties == SDDs are defined with respect to a generalization of variable ordering known as a variable tree (vtree). Provided that they satisfy additional properties known as compression and trimming (which are analogous to ROBDDs), SDDs are a canonical representation of Boolean functions; that is, they are unique given a vtree. Like OBDDs, they allow for operations such as conjunction, disjunction and negation to be computed directly on the representation in polynomial time, while being potentially more compact. They also allow for polynomial-time model counting. SDDs are known to be exponentially more succinct than OBDDs. == Applications == SDDs are used as a compilation target for probabilistic logic programs by the ProbLog 2 system since they support tractable (weighted) model counting as well as tractable negation, conjunction and disjunction while being more succinct than BDDs. SDDs have also been extended to model probability distributions, in which context they are known as probabilistic sentential decision diagrams (PSDD).

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  • Lighthill report

    Lighthill report

    Artificial Intelligence: A General Survey, commonly known as the Lighthill report, is a scholarly article by James Lighthill, published in Artificial Intelligence: a paper symposium in 1973. It was compiled by Lighthill for the British Science Research Council as an evaluation of academic research in the field of artificial intelligence (AI). The report gave a very pessimistic prognosis for many core aspects of research in this field, stating that "In no part of the field have the discoveries made so far produced the major impact that was then promised". It "formed the basis for the decision by the British government to end support for AI research in most British universities", contributing to an AI winter in the United Kingdom. == Publication history == It was commissioned by the SRC in 1972 for Lighthill to "make a personal review of the subject [of AI]". Lighthill completed the report in July. The SRC discussed the report in September, and decided to publish it, together with some alternative points of view by Stuart Sutherland, Roger Needham, Christopher Longuet-Higgins, and Donald Michie. The SRC's decision to invite the report was partly a reaction to high levels of discord within the University of Edinburgh's Department of Artificial Intelligence, one of the earliest and biggest centres for AI research in the UK. On May 9, 1973, Lighthill debated several leading AI researchers (Donald Michie, John McCarthy, Richard Gregory) at the Royal Institution in London concerning the report. == Content == While the report was supportive of research into the simulation of neurophysiological and psychological processes, it was "highly critical of basic research in foundational areas such as robotics and language processing". The report stated that AI researchers had failed to address the issue of combinatorial explosion when solving problems within real-world domains. That is, the report states that whilst AI techniques may have worked within the scope of small problem domains, the techniques would not scale up well to solve more realistic problems. The report represents a pessimistic view of AI that began after early excitement in the field. The report divides AI research into three categories: Advanced Automation ("A"): applications of AI, such as optical character recognition, mechanical component design and manufacture, missile perception and guidance, etc. Computer-based Central Nervous System research ("C"): building computational models of human brains (neurobiology) and behavior (psychology). Bridge, or Building Robots ("B"): research that combines categories A and C. This category is intentionally vague. Projects in category A had had some success, but only in restricted domains where a large quantity of detailed knowledge was used in designing the program. This was disappointing to researchers who hoped for generic methods. Due to the issue of the combinatorial explosion, the amount of detailed knowledge required by the program quickly grew too large to be entered by hand, thus restricting projects to restricted domains. Projects in category C had had some measure of success. Artificial neural networks were successfully used to model neurobiological data. SHRDLU demonstrated that human use of language, even in fine details, depends on the semantics or knowledge, and is not purely syntactical. This was influential in psycholinguistics. Attempts to extend SHRDLU to larger domains of discourse was considered impractical, again due to the issue of the combinatorial explosion. Projects in category B were held to be failures. One important project, that of "programming and building a robot that would mimic human ability in a combination of eye-hand co-ordination and common-sense problem solving", was considered entirely disappointing. Similarly, chess playing programs were no better than human amateurs. Due to the combinatorial explosion, the run-time of general algorithms quickly grew impractical, requiring detailed problem-specific heuristics. The report stated that it was expected that within the next 25 years, category A would simply become applied technologies engineering, C would integrate with psychology and neurobiology, while category B would be abandoned.

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  • User modeling

    User modeling

    User modeling is the subdivision of human–computer interaction which describes the process of building up and modifying a conceptual understanding of the user. The main goal of user modeling is customization and adaptation of systems to the user's specific needs. The system needs to "say the 'right' thing at the 'right' time in the 'right' way". To do so it needs an internal representation of the user. Another common purpose is modeling specific kinds of users, including modeling of their skills and declarative knowledge, for use in automatic software-tests. User-models can thus serve as a cheaper alternative to user testing but should not replace user testing. == Background == A user model is the collection and categorization of personal data associated with a specific user. A user model is a (data) structure that is used to capture certain characteristics about an individual user, and a user profile is the actual representation in a given user model. The process of obtaining the user profile is called user modeling. Therefore, it is the basis for any adaptive changes to the system's behavior. Which data is included in the model depends on the purpose of the application. It can include personal information such as users' names and ages, their interests, their skills and knowledge, their goals and plans, their preferences and their dislikes or data about their behavior and their interactions with the system. There are different design patterns for user models, though often a mixture of them is used. Static user models Static user models are the most basic kinds of user models. Once the main data is gathered they are normally not changed again, they are static. Shifts in users' preferences are not registered and no learning algorithms are used to alter the model. Dynamic user models Dynamic user models allow a more up to date representation of users. Changes in their interests, their learning progress or interactions with the system are noticed and influence the user models. The models can thus be updated and take the current needs and goals of the users into account. Stereotype based user models Stereotype based user models are based on demographic statistics. Based on the gathered information users are classified into common stereotypes. The system then adapts to this stereotype. The application therefore can make assumptions about a user even though there might be no data about that specific area, because demographic studies have shown that other users in this stereotype have the same characteristics. Thus, stereotype based user models mainly rely on statistics and do not take into account that personal attributes might not match the stereotype. However, they allow predictions about a user even if there is rather little information about him or her. Highly adaptive user models Highly adaptive user models try to represent one particular user and therefore allow a very high adaptivity of the system. In contrast to stereotype based user models they do not rely on demographic statistics but aim to find a specific solution for each user. Although users can take great benefit from this high adaptivity, this kind of model needs to gather a lot of information first. == Data gathering == Information about users can be gathered in several ways. There are three main methods: Asking for specific facts while (first) interacting with the system Mostly this kind of data gathering is linked with the registration process. While registering users are asked for specific facts, their likes and dislikes and their needs. Often the given answers can be altered afterwards. Learning users' preferences by observing and interpreting their interactions with the system In this case users are not asked directly for their personal data and preferences, but this information is derived from their behavior while interacting with the system. The ways they choose to accomplish a tasks, the combination of things they takes interest in, these observations allow inferences about a specific user. The application dynamically learns from observing these interactions. Different machine learning algorithms may be used to accomplish this task. A hybrid approach which asks for explicit feedback and alters the user model by adaptive learning This approach is a mixture of the ones above. Users have to answer specific questions and give explicit feedback. Furthermore, their interactions with the system are observed and the derived information are used to automatically adjust the user models. Though the first method is a good way to quickly collect main data it lacks the ability to automatically adapt to shifts in users' interests. It depends on the users' readiness to give information and it is unlikely that they are going to edit their answers once the registration process is finished. Therefore, there is a high likelihood that the user models are not up to date. However, this first method allows the users to have full control over the collected data about them. It is their decision which information they are willing to provide. This possibility is missing in the second method. Adaptive changes in a system that learns users' preferences and needs only by interpreting their behavior might appear a bit opaque to the users, because they cannot fully understand and reconstruct why the system behaves the way it does. Moreover, the system is forced to collect a certain amount of data before it is able to predict the users' needs with the required accuracy. Therefore, it takes a certain learning time before a user can benefit from adaptive changes. However, afterwards these automatically adjusted user models allow a quite accurate adaptivity of the system. The hybrid approach tries to combine the advantages of both methods. Through collecting data by directly asking its users it gathers a first stock of information which can be used for adaptive changes. By learning from the users' interactions it can adjust the user models and reach more accuracy. Yet, the designer of the system has to decide, which of these information should have which amount of influence and what to do with learned data that contradicts some of the information given by a user. == System adaptation == Once a system has gathered information about a user it can evaluate that data by preset analytical algorithm and then start to adapt to the user's needs. These adaptations may concern every aspect of the system's behavior and depend on the system's purpose. Information and functions can be presented according to the user's interests, knowledge or goals by displaying only relevant features, hiding information the user does not need, making proposals what to do next and so on. One has to distinguish between adaptive and adaptable systems. In an adaptable system the user can manually change the system's appearance, behavior or functionality by actively selecting the corresponding options. Afterwards the system will stick to these choices. In an adaptive system a dynamic adaption to the user is automatically performed by the system itself, based on the built user model. Thus, an adaptive system needs ways to interpret information about the user in order to make these adaptations. One way to accomplish this task is implementing rule-based filtering. In this case a set of IF... THEN... rules is established that covers the knowledge base of the system. The IF-conditions can check for specific user-information and if they match the THEN-branch is performed which is responsible for the adaptive changes. Another approach is based on collaborative filtering. In this case information about a user is compared to that of other users of the same systems. Thus, if characteristics of the current user match those of another, the system can make assumptions about the current user by presuming that he or she is likely to have similar characteristics in areas where the model of the current user is lacking data. Based on these assumption the system then can perform adaptive changes. == Usages == Adaptive hypermedia: In an adaptive hypermedia system the displayed content and the offered hyperlinks are chosen on basis of users' specific characteristics, taking their goals, interests, knowledge and abilities into account. Thus, an adaptive hypermedia system aims to reduce the "lost in hyperspace" syndrome by presenting only relevant information. Adaptive educational hypermedia: Being a subdivision of adaptive hypermedia the main focus of adaptive educational hypermedia lies on education, displaying content and hyperlinks corresponding to the user's knowledge on the field of study. Intelligent tutoring system: Unlike adaptive educational hypermedia systems intelligent tutoring systems are stand-alone systems. Their aim is to help students in a specific field of study. To do so, they build up a user model where they store information about abilities, knowledge and needs of the user. The system can now adapt to this user by presenting approp

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  • Scenery generator

    Scenery generator

    A scenery generator (or terrain generator) is a software used to create landscape images, 3D models, and animations. These programs often use procedural generation to generate the landscapes, or sometimes created and rendered by a 3D artist. These programs are often used in video games or movies. Basic elements of landscapes created by scenery generators include terrain, water, foliage, and clouds. The process for basic random generation uses a diamond square algorithm. == Common features == Most scenery generators can create basic heightmaps to simulate the variation of elevation in basic terrain. Common techniques include Simplex noise, fractals, or the diamond-square algorithm, which can generate 2-dimensional heightmaps. A version of scenery generator can be very simplistic. Using a diamond-square algorithm with some extra steps involving fractals, an algorithm for random generation of terrain can be made with only 120 lines of code. The program in example takes a grid and then divides the grid repeatedly. Each smaller grid is then split into squares and diamonds and the algorithm then makes the randomized terrain for each square and diamond. Most programs for creating landscapes also allow for adjustment and editing of the landscape. For example, World Creator allows for terrain sculpting, which uses a similar brush system as Photoshop, and allows for additional terrain enhancement with its procedural techniques such as erosion, sediments, and more. Other tools in the World Creator program include terrain stamping, which allows you to import elevation maps and use them as a base. The programs tend to also allow for additional placement of rocks, trees, etc. These can be done procedurally or by hand depending on the program. Typically the models used for the placement objects are the same as to lessen the amount of work that would be done if the user was to create a multitude of different trees. The terrain generated the computer does a generation of multifractals then integrates them until finally rendering them onto the screen. These techniques are typically done “on-the-fly” which typically for a 128 × 128 resolution terrain would mean 1.5 seconds on a CPU from the early 1990s. == Applications == Scenery generators are commonly used in movies, animations, 3D rendering, and video games. For example, Industrial Light & Magic used E-on Vue to create the fictional environments for Pirates of the Caribbean: Dead Man's Chest. In such live-action cases, a 3D model of the generated environment is rendered and blended with live-action footage. Scenery generated by the software may also be used to create completely computer-generated scenes. In the case of animated movies such as Kung Fu Panda, the raw generation is assisted by hand-painting to accentuate subtle details. Environmental elements not commonly associated with landscapes, such as ocean waves, have also been handled by the software. Scenery generation is used in most 3D based video-games. These typically use either custom or purchased engines that contain their own scenery generators. For some games they tend to use a procedurally generated terrain. These typically use a form of height mapping and use of Perlin noise. This will create a grid that with one point in a 2D coordinate will create the same heightmap as it is pseudorandom, meaning it will result in the same output with the same input. This can then easily be translated into the product 3D image. These can then be changed from the editor tools in most engines if the terrain will be custom built. With recent developments neural networks can be built to create or texture the terrain based on previously suggested artwork or heightmap data. These would be generated using algorithms that have been able to identify images and similarities between them. With the info the machine can take other heightmaps and render a very similar looking image to the style image. This can be used to create similar images in example a Studio Ghibli or Van Gogh art-style. == Software == Most game engines, whether custom or proprietary, will have terrain generation built in. Some terrain generator programs include, Terragen, which can create terrain, water, atmosphere and lighting; L3DT, which provides similar functions to Terragen, and has a 2048 × 2048 resolution limit; and World Creator, which can create terrain, and is fully GPU powered. === List of 3D terrain generation software ===

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  • Turing test

    Turing test

    The Turing test, originally called the imitation game by Alan Turing in 1949, is a test of a machine's ability to exhibit intelligent behaviour equivalent to that of a human. In the test, a human evaluator judges a text transcript of a natural-language conversation between a human and a machine. The evaluator tries to identify the machine, and the machine passes if the evaluator cannot reliably tell them apart. The results would not depend on the machine's ability to answer questions correctly, only on how closely its answers resembled those of a human. Since the Turing test is a test of indistinguishability in performance capacity, the verbal version generalizes naturally to all of human performance capacity, verbal as well as nonverbal (robotic). The test was introduced by Turing in his 1950 paper "Computing Machinery and Intelligence" while working at the University of Manchester. It opens with the words: "I propose to consider the question, 'Can machines think?'." Because "thinking" is difficult to define, Turing chooses to "replace the question by another, which is closely related to it and is expressed in relatively unambiguous words". Turing describes the new form of the problem in terms of a three-person party game called the "imitation game", in which an interrogator asks questions of a man and a woman in another room in order to determine the correct sex of the two players. Turing's new question is: "Are there imaginable digital computers which would do well in the imitation game?" This question, Turing believed, was one that could actually be answered. In the remainder of the paper, he argued against the major objections to the proposition that "machines can think". Since Turing introduced his test, it has been highly influential in the philosophy of artificial intelligence, resulting in substantial discussion and controversy, as well as criticism from philosophers like John Searle, who argue against the test's ability to detect consciousness. == History == === Philosophical background === The question of whether it is possible for machines to think has a long history, which is firmly entrenched in the distinction between dualist and materialist views of the mind. René Descartes prefigures aspects of the Turing test in his 1637 Discourse on the Method when he writes: [H]ow many different automata or moving machines could be made by the industry of man ... For we can easily understand a machine's being constituted so that it can utter words, and even emit some responses to action on it of a corporeal kind, which brings about a change in its organs; for instance, if touched in a particular part it may ask what we wish to say to it; if in another part it may exclaim that it is being hurt, and so on. But it never happens that it arranges its speech in various ways, in order to reply appropriately to everything that may be said in its presence, as even the lowest type of man can do. Here Descartes notes that automata are capable of responding to human interactions but argues that such automata cannot respond appropriately to things said in their presence in the way that any human can. Descartes therefore prefigures the Turing test by defining the insufficiency of appropriate linguistic response as that which separates the human from the automaton. Descartes fails to consider the possibility that future automata might be able to overcome such insufficiency, and so does not propose the Turing test as such, even if he prefigures its conceptual framework and criterion. Denis Diderot formulates in his 1746 book Pensées philosophiques a Turing-test criterion, though with the important implicit limiting assumption maintained, of the participants being natural living beings, rather than considering created artifacts: If they find a parrot who could answer to everything, I would claim it to be an intelligent being without hesitation. This does not mean he agrees with this, but that it was already a common argument of materialists at that time. According to dualism, the mind is non-physical (or, at the very least, has non-physical properties) and, therefore, cannot be explained in purely physical terms. According to materialism, the mind can be explained physically, which leaves open the possibility of minds that are produced artificially. In 1936, philosopher Alfred Ayer considered the standard philosophical question of other minds: how do we know that other people have the same conscious experiences that we do? In his book, Language, Truth and Logic, Ayer suggested a protocol to distinguish between a conscious man and an unconscious machine: "The only ground I can have for asserting that an object which appears to be conscious is not really a conscious being, but only a dummy or a machine, is that it fails to satisfy one of the empirical tests by which the presence or absence of consciousness is determined". (This suggestion is very similar to the Turing test, but it is not certain that Ayer's popular philosophical classic was familiar to Turing.) In other words, a thing is not conscious if it fails the consciousness test. === Cultural background === A rudimentary idea of the Turing test appears in the 1726 novel Gulliver's Travels by Jonathan Swift. When Gulliver is brought before the king of Brobdingnag, the king thinks at first that Gulliver might be a "a piece of clock-work (which is in that country arrived to a very great perfection) contrived by some ingenious artist". Even when he hears Gulliver speaking, the king still doubts whether Gulliver was taught "a set of words" to make him "sell at a better price". Gulliver tells that only after "he put several other questions to me, and still received rational answers" the king became satisfied that Gulliver was not a machine. Tests where a human judges whether a computer or an alien is intelligent were an established convention in science fiction by the 1940s, and it is likely that Turing would have been aware of these. Stanley G. Weinbaum's "A Martian Odyssey" (1934) provides an example of how nuanced such tests could be. Earlier examples of machines or automatons attempting to pass as human include the Ancient Greek myth of Pygmalion who creates a sculpture of a woman that is animated by Aphrodite, Carlo Collodi's novel The Adventures of Pinocchio, about a puppet who wants to become a real boy, and E. T. A. Hoffmann's 1816 story "The Sandman," where the protagonist falls in love with an automaton. In all these examples, people are fooled by artificial beings that—up to a point—pass as human. === Alan Turing and the imitation game === Researchers in the United Kingdom had been exploring "machine intelligence" for up to ten years prior to the founding of the field of artificial intelligence (AI) research in 1956. It was a common topic among the members of the Ratio Club, an informal group of British cybernetics and electronics researchers that included Alan Turing. Turing, in particular, had been running the notion of machine intelligence since at least 1941 and one of the earliest-known mentions of "computer intelligence" was made by him in 1947. In Turing's report, "Intelligent Machinery," he investigated "the question of whether or not it is possible for machinery to show intelligent behaviour" and, as part of that investigation, proposed what may be considered the forerunner to his later tests: It is not difficult to devise a paper machine which will play a not very bad game of chess. Now get three men A, B and C as subjects for the experiment. A and C are to be rather poor chess players, B is the operator who works the paper machine. ... Two rooms are used with some arrangement for communicating moves, and a game is played between C and either A or the paper machine. C may find it quite difficult to tell which he is playing. "Computing Machinery and Intelligence" (1950) was the first published paper by Turing to focus exclusively on machine intelligence. Turing begins the 1950 paper with the claim, "I propose to consider the question 'Can machines think?'" As he highlights, the traditional approach to such a question is to start with definitions, defining both the terms "machine" and "think". Turing chooses not to do so; instead, he replaces the question with a new one, "which is closely related to it and is expressed in relatively unambiguous words". In essence he proposes to change the question from "Can machines think?" to "Can machines do what we (as thinking entities) can do?" The advantage of the new question, Turing argues, is that it draws "a fairly sharp line between the physical and intellectual capacities of a man". To demonstrate this approach Turing proposes a test inspired by a party game, known as the "imitation game", in which a man and a woman go into separate rooms and guests try to tell them apart by writing a series of questions and reading the typewritten answers sent back. In this game, both the man and the woman aim to convince the guests that they ar

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  • Daniel Wolfe

    Daniel Wolfe

    Daniel Wolfe (born 1960) is an American activist, advocate, and writer whose work advances health programs and policy that balance scientific research and community expertise. His career has focused on support for community health movements, particularly among groups often regarded as criminal or socially suspect, including gay men and people who use illicit drugs. == Early life == Wolfe was raised between Arizona—including time on Rancho Linda Vista, a commune outside of Tucson—and East Hampton, NY. He received his undergraduate degree in Near Eastern Studies from Princeton University, and following time studying Arabic in Egypt, worked as the junior ghostwriter on the autobiographies of First Lady of Egypt Jehan Sadat and Pakistani Prime Minister Benazir Bhutto. Upon return to New York, he was an assistant at the Council on Foreign Relations to Richard W. Murphy, former US Assistant Secretary of State for Near Eastern and South Asian Affairs. Disagreement with US killing of Iraqi civilians during the 1990 Gulf War—and the rising toll of HIV in NY—moved Wolfe to leave Middle East studies and work full-time on AIDS in 1990. == Education == Wolfe was Community Scholar at the Columbia University Mailman School of Public Healthwhere he received his Masters in Public Health in 2004. He holds a Masters of Philosophy (in history) from Columbia University, and a BA in Near Eastern Studies from Princeton University. He was the recipient of a Charles H. Revson Foundation fellowship for urban leaders who have made a substantial contribution to New York City, and a fellow at the Center for Arabic Studies Abroad in Cairo, Egypt. == AIDS and gay activism == Wolfe was part of the media committee for ACT UP’s 1998 action to seize control of the FDA, and helped organize ACT UP NY’s challenge to Governor Cuomo to do better on the AIDS response and other actions.Wolfe also joined ACT UP colleagues Gregg Bordowitz, David Barr, Richard Elovich, Jean Carlomusto and others to work at Gay Men’s Health Crisis (GMHC), the nation’s first AIDS organization, where he served as director of communications and spokesperson on issues including opposition to NY State cuts to the AIDS budget, the disclosure that Olympic Champion Greg Louganis had HIV, reports of the FBI spying on AIDS activists, and GMHC’s move to offer HIV testing and targeted support to those who were HIV-negative. Wolfe also continued cultural work, making art, performance and video as a member of the gay and lesbian collective GANG with artists and ACT UP members including Zoe Leonard, Suzanne Wright, Loring McAlpin, Wellington Love, Adam Rolston and others, and writing a biography of Lawrence of Arabia for a series for young adults on famous gay men and lesbians in history edited by Martin Duberman. Controversy followed, with North Carolina Senator Jesse Helms waving a GANG piece in an issue of the Movement Research Performance Journal on the floor of Congress to show the "rottenness" of publicly funded art, and a number of schools banning the biography series for young adults from their libraries. Wolfe and others challenged the move as continuing the longstanding and homophobic demand that notable gay men and lesbians stay silent about essential details of their private lives even while being celebrated for their professional achievements. == Gay health == The approval of antiretroviral therapy for HIV in 1996 opened up new space for discussions of gay health beyond HIV, and new directions for Wolfe. Working from hundreds of interviews, surveys, workshops, and with a team of writers, Wolfe was the author of Men Like Us, the Our Bodies, Ourselves-inspired GMHC Complete Guide to Gay Men’s Sexual, Physical, and Emotional Well-being, covering issues from spirituality to sexual health to aging. The move to frame gay health beyond condoms and pills—and to offer a guide to health that “did not need to be translated from the original heterosexual”—was part of a larger gay health movement encompassing wellness and pleasure, and focused less on health disparity than on individual and community resilience. Wolfe was a keynote speaker and workshop leader, along with Eric Rofes, Chris Bartlett, and other organizers, at the first National Gay Men’s Health Summit held in Boulder, Colorado in 2002. Awarded a Charles H. Revson Fellowship for urban leaders in the City of New York, Wolfe became a community scholar at Columbia University’s Center of History and Ethics of Public Health, where he received his MPH in 2003, and was a contributor to Searching Eyes: Privacy, the State, and Disease Surveillance in America. == International harm reduction == Wolfe was Director of International Harm Reduction Development at the Open Society Foundations (2005-2021) where he led grantmaking and advocacy to protect the health and rights of people who use drugs in Eastern Europe, Asia, Africa and the Americas. Wolfe challenged approaches that conditioned support on abstinence or that sought to treat people who use illegal drugs like drugs themselves, as something to be controlled or contained. As with the gay health movement, he advocated a focus on community resilience and strengths, and on supporting individuals and communities to negotiate the balance between risk and pleasure of activities integral to life. Noting what he called the “antisocial behavior of health systems,” Wolfe’s analysis elevated issues such as forced labor and harsh punishment delivered in the name of addiction treatment and rehabilitation, the role of criminalization, imprisonment and stigma in interrupting or impeding HIV treatment, and the bias toward coercive approaches in studying and delivering addiction treatments. He also pointed to defects in national and international drug control policies and human rights violations as a root cause of HIV, hepatitis, and other health challenges faced by people who used drugs. Concrete advocacy supported by Open Society’s International Harm Reduction Development program under his direction included rebuffing US government efforts to force the UN to remove all references to harm reduction in its materials, addition of the addiction treatment medicines methadone and buprenorphine to the World Health Organization’s essential medicines list, and WHO endorsement of lay distribution of the opioid overdose antidote naloxone. Wolfe and OSF colleagues also advocated for new approaches to intellectual property and data sharing in research and development of medicines and vaccines to lower price and improve access to medicines globally to those in need. == AI and patient rights == Reports of patients denied opioid prescriptions based on an algorithm purporting to calculate their risk of overdose led Wolfe to work on AI, first as a resident at the Rockefeller Foundation Bellagio Center, and then as Executive Director of a new UCSF UC Berkeley program pioneering efforts to join AI, clinical and public health practice, and equity. In keeping with his earlier (analog) work on HIV, Wolfe has highlighted concerns about health systems using algorithms to gauge the merit of treatments for those regarded as socially suspect, the importance of moving beyond proprietary, black box algorithms toward an architecture of health data as a public good, and the need to maximize benefit for patients and communities, as well health systems, in the use of large language models.

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  • Sriram Krishnan

    Sriram Krishnan

    Sriram Krishnan (born 1984) is a tech executive and White House official, currently serving as the Senior White House Policy Advisor on Artificial Intelligence. Krishnan was named a Time Person of the Year in 2025 as an "Architect of Artificial Intelligence." He was described in Time as providing the "wake-up call that we needed" to the other AI builders, leading to "a multiyear, $500 billion initiative dubbed Stargate" to push American-made AI, as well as numerous other AI initiatives. Also in December 2025, President Trump said of Krishnan, "without him, things on AI would not function well" and cited Krishnan as the leading figure behind the American executive order on AI. As the leader of the United States' policy team regarding artificial intelligence, Krishnan plays "a significant role in shaping the administration’s approach to AI and driving measures to advance federal adoption of AI." The role calls for removing barriers to AI adoption within the government, driving vendors toward solutions suitable for federal needs, designing sensible regulation of private-sector AI, and conducting "AI diplomacy". He has stated a policy goal of "reinvigorating US dominance in emerging technologies," including AI. He also represents the United States' interests in AI abroad, such as at the Paris AI Summit. He is one of the authors of the American "AI Action Plan" released in July, 2025, which he contends is necessary to win the "existential race with China" for AI supremacy. Krishnan, a U.S. citizen born in India, is also a venture capitalist, podcaster, product manager and author. Early in his career, he led product teams at Microsoft, Twitter, Yahoo!, Facebook, and Snap. In addition to his work as an investor and technologist, he and his wife, Aarthi Ramamurthy, rose to additional prominence in 2021 as podcast hosts. He served as a general partner at the venture capital firm Andreessen Horowitz and led its London office. In 2022, Krishnan announced that he was working with Elon Musk on the rebuilding of Twitter following Musk's acquisition of the company. On December 22, 2024, US president-elect Donald Trump announced that Krishnan would be Senior White House Policy Advisor on Artificial Intelligence in his incoming administration; in 2026 he joined the National Economic Council. == Early life and education == Krishnan was born in Chennai, India. He earned his Bachelor of Technology in Information Technology from SRM University (2001–2005), moved to the United States in 2007 to join Microsoft, and became a naturalized U.S. citizen in 2016. == Career == === Early career === In 2007, he began working at Microsoft where he served as a program manager for Visual Studio. At Facebook, Krishnan built the Facebook Audience Network, a competitive platform to Google's ad technologies. At Twitter, he led product and core user experience, driving a 20% annual user growth rate and launching a redesigned home page and events experience. === Andreessen Horowitz === Krishnan was appointed a general partner of American venture capital firm Andreessen Horowitz ("a16z") in February 2021. He was anticipated to serve consumer and social markets, however he has also theorized on the impact of "deep tech" on society. In 2023 he was appointed to lead the firm's London office, its first non-US location. The office is expected to serve Web3 investments as well as AI and other fields. Krishnan announced that he would leave the firm at the end of 2024. === Social media and AI === In 2022, various news media reported that Krishnan was assisting Elon Musk in the revamp of Twitter following Musk's takeover of the company. Additional reports named Krishnan as the leading candidate for the role of CEO of the newly private company. Krishnan penned a 2023 New York Times opinion column regarding social media, AI, and related fields. He predicted a rise in the number and diversity of online spaces due to decentralization and platforms like Farcaster, Bluesky and Mastodon. === Public office === In 2024, the Financial Times reported that Krishnan was active in international affairs, reintroducing Boris Johnson to Elon Musk, following Musk's nomination to the proposed Department of Government Efficiency. Krishnan was also reported as potentially leaving a16z at the end of the year to "be jumping into something I've wanted to spend [his] energy on," which was widely reported as being related to Musk's and Vivek Ramaswamy's work at DOGE. Others reported to be involved include Joe Lonsdale, Marc Andreesen, Bill Ackman, and Travis Kalanick. On December 22, 2024, US president-elect Donald Trump announced that he would be Senior White House Policy Advisor on Artificial Intelligence in his incoming administration. On February 6, 2025, Reuters reported that Krishnan would be accompanying Vice President Vance to the Paris AI Summit, a "major artificial intelligence" event later that month. Other members of the White House Office of Science and Technology Policy would also be joining the event with around 100 other countries to "focus on AI's potential." Krishnan joined a U.S. technology policy delegation to the Middle East in advance of President Trump's visit in May 2025. Conducting "AI diplomacy," Krishnan negotiated the spread of U.S. AI technologies with Crown Prince Mohammed bin Salman of Saudi Arabia, as well as other means to strengthen bilateral trade in artificial intelligence technologies. He explained that the goal of the diplomatic mission was that "we want American A.I. to spread." Krishnan, along with David Sacks and Michael Kratsios, were credited as authors of the American AI Action Plan released in July 2025. The plan is "the administration’s most significant policy directive" regarding artificial intelligence; it calls for financing to support the global spread of American AI models and a policy to enforce neutrality in models. The Washington Post referred to the plan as a "bold action to ensure that American AI remains at the cutting edge." The AI Action Plan is a continuation of prior efforts to reduce barriers to U.S. production of AI systems and the removal of rules that were considered to hinder such growth. Later in 2025, at the POLITICO AI & Tech Summit, Krishnan called national AI development "an existential race with China." He suggested that private companies are best positioned to create new models, quipping "let them cook." He further suggested that state-by-state regulation of AI technologies may hinder national AI competitiveness. Also in 2025, at the Axios AI+ Summit, Krishnan stated that the United States and China are in a race for AI supremacy, in which the winner will be judged by market share. Winning the race is a "business strategy" to Krishnan. Krishnan was named in the 2025 Time Person of the Year article as an "AI Architect". === The Aarthi and Sriram Show and other media === In early 2021, Krishnan and his wife, Aarthi Ramamurthy, launched a Clubhouse talk show that "focuses on organic conversations on anything from startups to venture capitalism and cryptocurrencies." An early appearance by Elon Musk on the Good Time Show was described as the first show that "broke Clubhouse" by rapidly exceeding the limit of 5,000 simultaneous users. The desire to interact with a larger community led to a variety of later innovations to allow streaming and replaying of Clubhouse chats. On that episode, Elon Musk grilled Robinhood CEO Vlad Tenev regarding the GameStop trading controversy. As of December 2021, the show had over 187,000 subscribers, plus 735,000 subscribers between Krishnan and Ramamurthy's personal Clubhouse accounts. Other guests have included Facebook CEO Mark Zuckerberg, Diane von Fürstenberg, Tony Hawk, MrBeast, and A.R. Rahman. In 2022, the Good Time Show moved to YouTube. It then evolved to a podcasting format under the name The Aarthi and Sriram Show, with both audio and video content. The Hollywood Reporter reported that the podcast had received more than 1 million downloads by early 2023. == Personal life == Krishnan is married to Aarthi Ramamurthy, co-host of The Aarthi and Sriram Show (formerly the Good Time Show) and a serial entrepreneur. They met in college in 2003 through a Yahoo! chat room related to a coding project and began dating in 2006 and eloped in 2010. == Awards == Time Person of the Year - 2025

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  • Phase stretch transform

    Phase stretch transform

    Phase stretch transform (PST) is a computational approach to signal and image processing. One of its utilities is for feature detection and classification. PST is related to time stretch dispersive Fourier transform. It transforms the image by emulating propagation through a diffractive medium with engineered 3D dispersive property (refractive index). The operation relies on symmetry of the dispersion profile and can be understood in terms of dispersive eigenfunctions or stretch modes. PST performs similar functionality as phase-contrast microscopy, but on digital images. PST can be applied to digital images and temporal (time series) data. It is a physics-based feature engineering algorithm. == Operation principle == Here the principle is described in the context of feature enhancement in digital images. The image is first filtered with a spatial kernel followed by application of a nonlinear frequency-dependent phase. The output of the transform is the phase in the spatial domain. The main step is the 2-D phase function which is typically applied in the frequency domain. The amount of phase applied to the image is frequency dependent, with higher amount of phase applied to higher frequency features of the image. Since sharp transitions, such as edges and corners, contain higher frequencies, PST emphasizes the edge information. Features can be further enhanced by applying thresholding and morphological operations. PST is a pure phase operation whereas conventional edge detection algorithms operate on amplitude. == Physical and mathematical foundations of phase stretch transform == Photonic time stretch technique can be understood by considering the propagation of an optical pulse through a dispersive fiber. By disregarding the loss and non-linearity in fiber, the non-linear Schrödinger equation governing the optical pulse propagation in fiber upon integration reduces to: E o ( z , t ) = 1 2 π ∫ − ∞ ∞ E ~ i ( 0 , ω ) ⋅ e − i β 2 z ω 2 2 ⋅ e i ω t d ω {\displaystyle E_{o}(z,t)={\frac {1}{2\pi }}\int _{-\infty }^{\infty }{\tilde {E}}_{i}(0,\omega )\cdot e^{\frac {-i\beta _{2}z\omega ^{2}}{2}}\cdot e^{i\omega {t}}\,d\omega } (1) where β 2 {\displaystyle \beta _{2}} = GVD parameter, z is propagation distance, E o ( z , t ) {\displaystyle E_{o}(z,t)} is the reshaped output pulse at distance z and time t. The response of this dispersive element in the time-stretch system can be approximated as a phase propagator as presented in H ( ω ) = e i φ ( ω ) = e i ∑ m = 0 ∞ φ m ( ω ) = ∏ m = 0 ∞ H m ( ω ) {\displaystyle H(\omega )=e^{i\varphi (\omega )}=e^{i\sum _{m=0}^{\infty }\varphi _{m}(\omega )}=\prod _{m=0}^{\infty }H_{m}(\omega )} (2) Therefore, Eq. 1 can be written as following for a pulse that propagates through the time-stretch system and is reshaped into a temporal signal with a complex envelope given by E o ( t ) = 1 2 π ∫ − ∞ ∞ E ~ i ( ω ) ⋅ H ( ω ) ⋅ e i ω t d ω {\displaystyle E_{o}(t)={\frac {1}{2\pi }}\int _{-\infty }^{\infty }{\tilde {E}}_{i}(\omega )\cdot H(\omega )\cdot e^{i\omega t}\,d\omega } (3) The time stretch operation is formulated as generalized phase and amplitude operations, S { E i ( t ) } = ∫ − ∞ + ∞ F { E i ( t ) } ⋅ e i φ ( ω ) ⋅ L ~ ( ω ) ⋅ e i ω t d ω {\displaystyle \mathbb {S} \{E_{i}(t)\}=\int _{-\infty }^{+\infty }{\mathcal {F}}\{E_{i}(t)\}\cdot e^{i\varphi (\omega )}\cdot {\tilde {L}}(\omega )\cdot e^{i\omega {t}}d\omega } (4) where e i φ ( ω ) {\displaystyle e^{i\varphi (\omega )}} is the phase filter and L ~ ( ω ) {\displaystyle {\tilde {L}}(\omega )} is the amplitude filter. Next the operator is converted to discrete domain, S { E i [ n ] } = 1 N ∑ u = 0 N − 1 F F T { E i ( n ) } ⋅ K ~ ( u ) ⋅ L ~ ( u ) ⋅ e i 2 π N u n {\displaystyle \mathbb {S} \{E_{i}[n]\}={\frac {1}{N}}\sum _{u=0}^{N-1}FFT\{E_{i}(n)\}\cdot {\tilde {K}}(u)\cdot {\tilde {L}}(u)\cdot e^{i{\frac {2\pi }{N}}un}} (5) where u {\displaystyle u} is the discrete frequency, K ~ ( u ) {\displaystyle {\tilde {K}}(u)} is the phase filter, L ~ ( u ) {\displaystyle {\tilde {L}}(u)} is the amplitude filter and FFT is fast Fourier transform. The stretch operator S { } {\displaystyle \mathbb {S} \{\}} for a digital image is then S { E i [ n , m ] } = 1 M N ∑ v = 0 N − 1 ∑ u = 0 M − 1 F F T 2 { E i ( n , m ) } ⋅ K ~ ( u , v ) ⋅ L ~ ( u , v ) ⋅ e i 2 π M u m ⋅ e i 2 π N v n {\displaystyle \mathbb {S} \{E_{i}[n,m]\}={\frac {1}{MN}}\sum _{v=0}^{N-1}\sum _{u=0}^{M-1}FFT^{2}\{E_{i}(n,m)\}\cdot {\tilde {K}}(u,v)\cdot {\tilde {L}}(u,v)\cdot e^{i{\frac {2\pi }{M}}um}\cdot e^{i{\frac {2\pi }{N}}vn}} (6) In the above equations, E i [ n , m ] {\displaystyle E_{i}[n,m]} is the input image, n {\displaystyle n} and m {\displaystyle m} are the spatial variables, F F T 2 {\displaystyle FFT^{2}} is the two-dimensional fast Fourier transform, and u {\displaystyle u} and v {\displaystyle v} are spatial frequency variables. The function K ~ ( u , v ) {\displaystyle {\tilde {K}}(u,v)} is the warped phase kernel and the function L ~ ( u , v ) {\displaystyle {\tilde {L}}(u,v)} is a localization kernel implemented in frequency domain. PST operator is defined as the phase of the Warped Stretch Transform output as follows P S T { E i [ n , m ] } ≜ ∡ { S { E i [ x , y ] } } {\displaystyle PST\{E_{i}[n,m]\}\triangleq \measuredangle \{\mathbb {S} \{E_{i}[x,y]\}\}} (7) where ∡ { } {\displaystyle \measuredangle \{\}} is the angle operator. == PST kernel implementation == The warped phase kernel K ~ ( u , v ) {\displaystyle {\tilde {K}}(u,v)} can be described by a nonlinear frequency dependent phase K ~ ( u , v ) = e i φ ( u , v ) {\displaystyle {\tilde {K}}(u,v)=e^{i\varphi (u,v)}} While arbitrary phase kernels can be considered for PST operation, here we study the phase kernels for which the kernel phase derivative is a linear or sublinear function with respect to frequency variables. A simple example for such phase derivative profiles is the inverse tangent function. Consider the phase profile in the polar coordinate system φ ( u , v ) = φ polar ( r , θ ) = φ polar ( r ) {\displaystyle \varphi (u,v)=\varphi _{\text{polar}}(r,\theta )=\varphi _{\text{polar}}(r)} From d φ ( r ) d r = tan − 1 ⁡ ( r ) {\displaystyle {\frac {d\varphi (r)}{dr}}=\tan ^{-1}(r)} we have φ ( r ) = r tan − 1 ⁡ ( r ) − 1 2 log ⁡ ( r 2 + 1 ) {\displaystyle \varphi (r)=r\tan ^{-1}(r)-{\frac {1}{2}}\log(r^{2}+1)} Therefore, the PST kernel is implemented as φ ( r ) = S ⋅ ( W r ) ⋅ tan − 1 ⁡ ( W r ) − 1 2 log ⁡ ( 1 + ( W r ) 2 ) ( W r max ) ⋅ tan − 1 ⁡ ( W r max ) − 1 2 log ⁡ ( 1 + ( W r max ) 2 ) {\displaystyle \varphi (r)=S\cdot {\frac {(Wr)\cdot \tan ^{-1}(Wr)-{\frac {1}{2}}\log(1+(Wr)^{2})}{(Wr_{\max })\cdot \tan ^{-1}(Wr_{\max })-{\frac {1}{2}}\log(1+(Wr_{\max })^{2})}}} where S {\displaystyle S} and W {\displaystyle W} are real-valued numbers related to the strength and warp of the phase profile == Applications == PST has been used for edge detection in biological and biomedical images as well as synthetic-aperture radar (SAR) image processing, as well as detail and feature enhancement for digital images. PST has also been applied to improve the point spread function for single molecule imaging in order to achieve super-resolution. The transform exhibits intrinsic superior properties compared to conventional edge detectors for feature detection in low contrast visually impaired images. The PST function can also be performed on 1-D temporal waveforms in the analog domain to reveal transitions and anomalies in real time. == Open source code release == On February 9, 2016, a UCLA Engineering research group has made public the computer code for PST algorithm that helps computers process images at high speeds and "see" them in ways that human eyes cannot. The researchers say the code could eventually be used in face, fingerprint, and iris recognition systems for high-tech security, as well as in self-driving cars' navigation systems or for inspecting industrial products. The Matlab implementation for PST can also be downloaded from Matlab Files Exchange. However, it is provided for research purposes only, and a license must be obtained for any commercial applications. The software is protected under a US patent. The code was then significantly refactored and improved to support GPU acceleration. In May 2022, it became one algorithm in PhyCV: the first physics-inspired computer vision library.

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  • ChipTest

    ChipTest

    ChipTest was a 1985 chess playing computer built by Feng-hsiung Hsu, Thomas Anantharaman and Murray Campbell at Carnegie Mellon University. It is the predecessor of Deep Thought which in turn evolved into Deep Blue. == History == ChipTest was based on a special VLSI-technology move generator chip developed by Hsu. ChipTest was controlled by a Sun-3/160 workstation and capable of searching approximately 50,000 moves per second. Hsu and Anantharaman entered ChipTest in the 1986 North American Computer Chess Championship, and it was only partially tested when the tournament began. It lost its first two rounds, but finished with an even score. In August 1987, ChipTest was overhauled and renamed ChipTest-M, M standing for microcode. The new version had eliminated ChipTest's bugs and was ten times faster, searching 500,000 moves per second and running on a Sun-4 workstation. ChipTest-M won the North American Computer Chess Championship in 1987 with a 4–0 sweep. ChipTest was invited to play in the 1987 American Open, but the team did not enter due to an objection by the HiTech team, also from Carnegie Mellon University. HiTech and ChipTest shared some code, and Hitech was already playing in the tournament. The two teams became rivals. Designing and implementing ChipTest revealed many possibilities for improvement, so the designers started on a new machine. Deep Thought 0.01 was created in May 1988 and the version 0.02 in November the same year. This new version had two customized VLSI chess processors and it was able to search 720,000 moves per second. With the "0.02" dropped from its name, Deep Thought won the World Computer Chess Championship with a perfect 5–0 score in 1989.

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  • Composite portrait

    Composite portrait

    Composite portraiture (also known as composite photographs) is a technique invented by Sir Francis Galton in the 1880s after a suggestion by Herbert Spencer for registering photographs of human faces on the two eyes to create an "average" photograph of all those in the photographed group. Spencer had suggested using onion paper and line drawings, but Galton devised a technique for multiple exposures on the same photographic plate. He noticed that these composite portraits were more attractive than any individual member, and this has generated a large body of research on human attractiveness and averageness one hundred years later. He also suggested in a Royal Society presentation in 1883 that the composites provided an interesting concrete representation of human ideal types and concepts. He discussed using the technique to investigate characteristics of common types of humanity, such as criminals. In his mind, it was an extension of the statistical techniques of averages and correlation. In this sense, it represents one of the first implementations of convolution factor analysis and neural networks in the understanding of knowledge representation in the human mind. Galton also suggested that the technique could be used for creating natural types of common objects. During the late 19th century, English psychometrician Sir Francis Galton attempted to define physiognomic characteristics of health, disease, beauty, and criminality, via a method of composite photography. Galton's process involved the photographic superimposition of two or more faces by multiple exposures. After averaging together photographs of violent criminals, he found that the composite appeared "more respectable" than any of the faces comprising it; this was likely due to the irregularities of the skin across the constituent images being averaged out in the final blend. Since the advancement of computer graphics technology in the early 1990s, Galton's composite technique has been adopted and greatly improved using computer graphics software.

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