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  Hybrid intelligent system

  Hybrid intelligent system denotes a software system which employs, in parallel, a combination of methods and techniques from artificial intelligence subfields, such as: Neuro-symbolic systems Neuro-fuzzy systems Hybrid connectionist-symbolic models Fuzzy expert systems Connectionist expert systems Evolutionary neural networks Genetic fuzzy systems Rough fuzzy hybridization Reinforcement learning with fuzzy, neural, or evolutionary methods as well as symbolic reasoning methods. From the cognitive science perspective, every natural intelligent system is hybrid because it performs mental operations on both the symbolic and subsymbolic levels. For the past few years, there has been an increasing discussion of the importance of A.I. Systems Integration. Based on notions that there have already been created simple and specific AI systems (such as systems for computer vision, speech synthesis, etc., or software that employs some of the models mentioned above) and now is the time for integration to create broad AI systems. Proponents of this approach are researchers such as Marvin Minsky, Ron Sun, Aaron Sloman, Angelo Dalli and Michael A. Arbib. An example hybrid is a hierarchical control system in which the lowest, reactive layers are sub-symbolic. The higher layers, having relaxed time constraints, are capable of reasoning from an abstract world model and performing planning (even by hybrid wisdom). Intelligent systems usually rely on hybrid reasoning processes, which include induction, deduction, abduction and reasoning by analogy.

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  Prefrontal cortex basal ganglia working memory

  Prefrontal cortex basal ganglia working memory (PBWM) is an algorithm that models working memory in the prefrontal cortex and the basal ganglia. It can be compared to long short-term memory (LSTM) in functionality, but is more biologically explainable. It uses the primary value learned value model to train prefrontal cortex working-memory updating system, based on the biology of the prefrontal cortex and basal ganglia. It is used as part of the Leabra framework and was implemented in Emergent in 2019. == Abstract == The prefrontal cortex has long been thought to subserve both working memory (the holding of information online for processing) and "executive" functions (deciding how to manipulate working memory and perform processing). Although many computational models of working memory have been developed, the mechanistic basis of executive function remains elusive. PBWM is a computational model of the prefrontal cortex to control both itself and other brain areas in a strategic, task-appropriate manner. These learning mechanisms are based on subcortical structures in the midbrain, basal ganglia and amygdala, which together form an actor/critic architecture. The critic system learns which prefrontal representations are task-relevant and trains the actor, which in turn provides a dynamic gating mechanism for controlling working memory updating. Computationally, the learning mechanism is designed to simultaneously solve the temporal and structural credit assignment problems. The model's performance compares favorably with standard backpropagation-based temporal learning mechanisms on the challenging 1-2-AX working memory task, and other benchmark working memory tasks. == Model == First, there are multiple separate stripes (groups of units) in the prefrontal cortex and striatum layers. Each stripe can be independently updated, such that this system can remember several different things at the same time, each with a different "updating policy" of when memories are updated and maintained. The active maintenance of the memory is in prefrontal cortex (PFC), and the updating signals (and updating policy more generally) come from the striatum units (a subset of basal ganglia units). PVLV provides reinforcement learning signals to train up the dynamic gating system in the basal ganglia. === Sensory input and motor output === The sensory input is connected to the posterior cortex which is connected to the motor output. The sensory input is also linked to the PVLV system. === Posterior cortex === The posterior cortex form the hidden layers of the input/output mapping. The PFC is connected with the posterior cortex to contextualize this input/output mapping. === PFC === The PFC (for output gating) has a localist one-to-one representation of the input units for every stripe. Thus, you can look at these PFC representations and see directly what the network is maintaining. The PFC maintains the working memory needed to perform the task. === Striatum === This is the dynamic gating system representing the striatum units of the basal ganglia. Every even-index unit within a stripe represents "Go", while the odd-index units represent "NoGo." The Go units cause updating of the PFC, while the NoGo units cause the PFC to maintain its existing memory representation. There are groups of units for every stripe. In the PBWM model in Emergent, the matrices represent the striatum. === PVLV === All of these layers are part of PVLV system. The PVLV system controls the dopaminergic modulation of the basal ganglia (BG). Thus, BG/PVLV form an actor-critic architecture where the PVLV system learns when to update. ==== SNrThal ==== SNrThal represents the substantia nigra pars reticulata (SNr) and the associated area of the thalamus, which produce a competition among the Go/NoGo units within a given stripe and mediates competition using k-winners-take-all dynamics. If there is more overall Go activity in a given stripe, then the associated SNrThal unit gets activated, and it drives updating in PFC. For every stripe, there is one unit in SNrThal. ==== VTA and SNc ==== Ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are part of the dopamine layer. This layer models midbrain dopamine neurons. They control the dopaminergic modulation of the basal ganglia.

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  Operational taxonomic unit

  An operational taxonomic unit (OTU) is an operational definition used to classify groups of closely related individuals. The term was originally introduced in 1963 by Robert R. Sokal and Peter H. A. Sneath in the context of numerical taxonomy, where an "operational taxonomic unit" is simply the group of organisms currently being studied. In this sense, an OTU is a pragmatic definition to group individuals by similarity, equivalent to but not necessarily in line with classical Linnaean taxonomy or modern evolutionary taxonomy. Nowadays, however, the term is commonly used in a different context and refers to clusters of (uncultivated or unknown) organisms, grouped by DNA sequence similarity of a specific taxonomic marker gene (originally coined as mOTU; molecular OTU). In other words, OTUs are pragmatic proxies for "species" at different taxonomic levels, in the absence of traditional systems of biological classification as are available for macroscopic organisms. For several years, OTUs have been the most commonly used units of diversity, especially when analysing small subunit 16S (for prokaryotes) or 18S rRNA (for eukaryotes) marker gene sequence datasets. == Molecular OTU by clustering of marker gene sequences == In the approach represented by DNA barcoding, a particular locus is chosen to be used as the marker gene for classification. This locus should be universally present in the scope selected, variable enough to be different among close-related species, and be flanked by conservative sequences that allow for easy amplification and detection. There are databases containing sequences for such marker genes from many different species, allowing for comparison. (Sometimes only using one locus does not provide sufficient resolution, so multiple marker genes are used. This is the case for plants, where rbcL+matK is common.) Sequences obtained this way can be clustered according to their similarity to one another, and operational taxonomic units are defined based on the similarity threshold set by the researcher. The exact threshold depends on the taxa in question and the mutational rates of the selected locus in the taxon. 97–99% are commonly used, but "it is now recognized to be somewhat arbitrary as sequence variation within and among species varies across taxa". 100% similarity (fully identical) is also common, also known as single variants. It remains debatable how well this commonly used method recapitulates true microbial species phylogeny or ecology. Although OTUs can be calculated differently when using different algorithms or thresholds, research by Schmidt et al. (2014) demonstrated that 16S-derived microbial OTUs were generally ecologically consistent across habitats and several clustering approaches. The number of OTUs defined may be inflated due to errors in DNA sequencing. === OTU clustering approaches === There are three main approaches to clustering OTUs: De novo, for which the clustering is based on similarities between sequencing reads. Closed-reference, for which the clustering is performed against a reference database of sequences. Open-reference, where clustering is first performed against a reference database of sequences, then any remaining sequences that could not be mapped to the reference are clustered de novo. Using a reference provides taxonomic context for the OTUs found. Alternatively, taxonomic context can be found after the construction of clusters by comparing representative sequences from clusters against a reference database. There are also specialized classifiers for this purpose which are much faster than naive comparison using BLAST. === OTU clustering algorithms === Hierarchical clustering algorithms (HCA): uclust & cd-hit & ESPRIT Bayesian clustering: CROP == Molecular OTU by other methods == In addition to similarity-based grouping, marker gene sequences can be sorted into OTUs using molecular phylogeny, k-mer composition, or hybrid methods combining these methods with similarity. There are also Bayesian tree-less methods and machine learning approaches. Using phylogeny often involves manually assigning terminal clades or single nodes to an OTU, so this is usually only done for refinement. Genome skimming can be used to obtain high-copy DNA without the need to choose marker genes or to design PCR primers for the chosen genes. It can provide fairly good coverage of organelle DNA and repetitive elements such as ribosomal DNA, both of which can be used like marker genes in OTU analysis. Whole-genome sequencing is more expensive and involves the production and processing of more data. By considering the entire genome, many (sometimes over 100) marker genes can be used at the same time, producing highly resolved phylogenies that correctly identify problematic taxa. It is also possible to use entire genomes for OTU assignment. For example, genomes from different bacterial species almost always have an average nucleotide identity lower than 95%, a fact that can be used to define new OTUs (and likely new species).

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  AdaBoost

  AdaBoost (short for Adaptive Boosting) is a statistical classification meta-algorithm formulated by Yoav Freund and Robert Schapire in 1995, who won the 2003 Gödel Prize for their work. It can be used in conjunction with many types of learning algorithm to improve performance. The output of multiple weak learners is combined into a weighted sum that represents the final output of the boosted classifier. Usually, AdaBoost is presented for binary classification, although it can be generalized to multiple classes or bounded intervals of real values. AdaBoost is adaptive in the sense that subsequent weak learners (models) are adjusted in favor of instances misclassified by previous models. In some problems, it can be less susceptible to overfitting than other learning algorithms. The individual learners can be weak, but as long as the performance of each one is slightly better than random guessing, the final model can be proven to converge to a strong learner. Although AdaBoost is typically used to combine weak base learners (such as decision stumps), it has been shown to also effectively combine strong base learners (such as deeper decision trees), producing an even more accurate model. Every learning algorithm tends to suit some problem types better than others, and typically has many different parameters and configurations to adjust before it achieves optimal performance on a dataset. AdaBoost (with decision trees as the weak learners) is often referred to as the best out-of-the-box classifier. When used with decision tree learning, information gathered at each stage of the AdaBoost algorithm about the relative 'hardness' of each training sample is fed into the tree-growing algorithm such that later trees tend to focus on harder-to-classify examples. == Training == AdaBoost refers to a particular method of training a boosted classifier. A boosted classifier is a classifier of the form F T ( x ) = ∑ t = 1 T f t ( x ) {\displaystyle F_{T}(x)=\sum _{t=1}^{T}f_{t}(x)} where each f t {\displaystyle f_{t}} is a weak learner that takes an object x {\displaystyle x} as input and returns a value indicating the class of the object. For example, in the two-class problem, the sign of the weak learner's output identifies the predicted object class and the absolute value gives the confidence in that classification. Each weak learner produces an output hypothesis h {\displaystyle h} which fixes a prediction h ( x i ) {\displaystyle h(x_{i})} for each sample in the training set. At each iteration t {\displaystyle t} , a weak learner is selected and assigned a coefficient α t {\displaystyle \alpha _{t}} such that the total training error E t {\displaystyle E_{t}} of the resulting t {\displaystyle t} -stage boosted classifier is minimized. E t = ∑ i E [ F t − 1 ( x i ) + α t h ( x i ) ] {\displaystyle E_{t}=\sum _{i}E[F_{t-1}(x_{i})+\alpha _{t}h(x_{i})]} Here F t − 1 ( x ) {\displaystyle F_{t-1}(x)} is the boosted classifier that has been built up to the previous stage of training and f t ( x ) = α t h ( x ) {\displaystyle f_{t}(x)=\alpha _{t}h(x)} is the weak learner that is being considered for addition to the final classifier. === Weighting === At each iteration of the training process, a weight w i , t {\displaystyle w_{i,t}} is assigned to each sample in the training set equal to the current error E ( F t − 1 ( x i ) ) {\displaystyle E(F_{t-1}(x_{i}))} on that sample. These weights can be used in the training of the weak learner. For instance, decision trees can be grown which favor the splitting of sets of samples with large weights. == Derivation == This derivation follows Rojas (2009): Suppose we have a data set { ( x 1 , y 1 ) , … , ( x N , y N ) } {\displaystyle \{(x_{1},y_{1}),\ldots ,(x_{N},y_{N})\}} where each item x i {\displaystyle x_{i}} has an associated class y i ∈ { − 1 , 1 } {\displaystyle y_{i}\in \{-1,1\}} , and a set of weak classifiers { k 1 , … , k L } {\displaystyle \{k_{1},\ldots ,k_{L}\}} each of which outputs a classification k j ( x i ) ∈ { − 1 , 1 } {\displaystyle k_{j}(x_{i})\in \{-1,1\}} for each item. After the ( m − 1 ) {\displaystyle (m-1)} -th iteration our boosted classifier is a linear combination of the weak classifiers of the form: C ( m − 1 ) ( x i ) = α 1 k 1 ( x i ) + ⋯ + α m − 1 k m − 1 ( x i ) , {\displaystyle C_{(m-1)}(x_{i})=\alpha _{1}k_{1}(x_{i})+\cdots +\alpha _{m-1}k_{m-1}(x_{i}),} where the class will be the sign of C ( m − 1 ) ( x i ) {\displaystyle C_{(m-1)}(x_{i})} . At the m {\displaystyle m} -th iteration we want to extend this to a better boosted classifier by adding another weak classifier k m {\displaystyle k_{m}} , with another weight α m {\displaystyle \alpha _{m}} : C m ( x i ) = C ( m − 1 ) ( x i ) + α m k m ( x i ) {\displaystyle C_{m}(x_{i})=C_{(m-1)}(x_{i})+\alpha _{m}k_{m}(x_{i})} So it remains to determine which weak classifier is the best choice for k m {\displaystyle k_{m}} , and what its weight α m {\displaystyle \alpha _{m}} should be. We define the total error E {\displaystyle E} of C m {\displaystyle C_{m}} as the sum of its exponential loss on each data point, given as follows: E = ∑ i = 1 N e − y i C m ( x i ) = ∑ i = 1 N e − y i C ( m − 1 ) ( x i ) e − y i α m k m ( x i ) {\displaystyle E=\sum _{i=1}^{N}e^{-y_{i}C_{m}(x_{i})}=\sum _{i=1}^{N}e^{-y_{i}C_{(m-1)}(x_{i})}e^{-y_{i}\alpha _{m}k_{m}(x_{i})}} Letting w i ( 1 ) = 1 {\displaystyle w_{i}^{(1)}=1} and w i ( m ) = e − y i C m − 1 ( x i ) {\displaystyle w_{i}^{(m)}=e^{-y_{i}C_{m-1}(x_{i})}} for m > 1 {\displaystyle m>1} , we have: E = ∑ i = 1 N w i ( m ) e − y i α m k m ( x i ) {\displaystyle E=\sum _{i=1}^{N}w_{i}^{(m)}e^{-y_{i}\alpha _{m}k_{m}(x_{i})}} We can split this summation between those data points that are correctly classified by k m {\displaystyle k_{m}} (so y i k m ( x i ) = 1 {\displaystyle y_{i}k_{m}(x_{i})=1} ) and those that are misclassified (so y i k m ( x i ) = − 1 {\displaystyle y_{i}k_{m}(x_{i})=-1} ): E = ∑ y i = k m ( x i ) w i ( m ) e − α m + ∑ y i ≠ k m ( x i ) w i ( m ) e α m = ∑ i = 1 N w i ( m ) e − α m + ∑ y i ≠ k m ( x i ) w i ( m ) ( e α m − e − α m ) {\displaystyle {\begin{aligned}E&=\sum _{y_{i}=k_{m}(x_{i})}w_{i}^{(m)}e^{-\alpha _{m}}+\sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}e^{\alpha _{m}}\\&=\sum _{i=1}^{N}w_{i}^{(m)}e^{-\alpha _{m}}+\sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}\left(e^{\alpha _{m}}-e^{-\alpha _{m}}\right)\end{aligned}}} Since the only part of the right-hand side of this equation that depends on k m {\displaystyle k_{m}} is ∑ y i ≠ k m ( x i ) w i ( m ) {\textstyle \sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}} , we see that the k m {\displaystyle k_{m}} that minimizes E {\displaystyle E} is the one in the set { k 1 , … , k L } {\displaystyle \{k_{1},\ldots ,k_{L}\}} that minimizes ∑ y i ≠ k m ( x i ) w i ( m ) {\textstyle \sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}} [assuming that α m > 0 {\displaystyle \alpha _{m}>0} ], i.e. the weak classifier with the lowest weighted error (with weights w i ( m ) = e − y i C m − 1 ( x i ) {\displaystyle w_{i}^{(m)}=e^{-y_{i}C_{m-1}(x_{i})}} ). To determine the desired weight α m {\displaystyle \alpha _{m}} that minimizes E {\displaystyle E} with the k m {\displaystyle k_{m}} that we just determined, we differentiate: d E d α m = d ( ∑ y i = k m ( x i ) w i ( m ) e − α m + ∑ y i ≠ k m ( x i ) w i ( m ) e α m ) d α m {\displaystyle {\frac {dE}{d\alpha _{m}}}={\frac {d(\sum _{y_{i}=k_{m}(x_{i})}w_{i}^{(m)}e^{-\alpha _{m}}+\sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}e^{\alpha _{m}})}{d\alpha _{m}}}} The value of α m {\displaystyle \alpha _{m}} that minimizes the above expression is: α m = 1 2 ln ⁡ ( ∑ y i = k m ( x i ) w i ( m ) ∑ y i ≠ k m ( x i ) w i ( m ) ) {\displaystyle \alpha _{m}={\frac {1}{2}}\ln \left({\frac {\sum _{y_{i}=k_{m}(x_{i})}w_{i}^{(m)}}{\sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}}}\right)} We calculate the weighted error rate of the weak classifier to be ϵ m = ∑ y i ≠ k m ( x i ) w i ( m ) ∑ i = 1 N w i ( m ) {\displaystyle \epsilon _{m}={\frac {\sum _{y_{i}\neq k_{m}(x_{i})}w_{i}^{(m)}}{\sum _{i=1}^{N}w_{i}^{(m)}}}} , so it follows that: α m = 1 2 ln ⁡ ( 1 − ϵ m ϵ m ) {\displaystyle \alpha _{m}={\frac {1}{2}}\ln \left({\frac {1-\epsilon _{m}}{\epsilon _{m}}}\right)} which is the negative logit function multiplied by 0.5. Due to the convexity of E {\displaystyle E} as a function of α m {\displaystyle \alpha _{m}} , this new expression for α m {\displaystyle \alpha _{m}} gives the global minimum of the loss function. Note: This derivation only applies when k m ( x i ) ∈ { − 1 , 1 } {\displaystyle k_{m}(x_{i})\in \{-1,1\}} , though it can be a good starting guess in other cases, such as when the weak learner is biased ( k m ( x ) ∈ { a , b } , a ≠ − b {\displaystyle k_{m}(x)\in \{a,b\},a\neq -b} ), has multiple leaves ( k m ( x ) ∈ { a , b , … , n } {\displaystyle k_{m}(x)\in \{a,b,\dots ,n\}} ) or is some other function k m ( x ) ∈ R {\displaystyle k_{m}(x)\in \mathbb {R} } . Thus we have derived the AdaBoost algorithm: At each

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  IOS SDK

  The iOS SDK (iOS Software Development Kit), formerly the iPhone SDK, is a software development kit (SDK) developed by Apple Inc. The kit allows for the development of mobile apps on Apple's iOS 17 and iPadOS operating systems. The iOS SDK is a free download for users of Macintosh (or Mac) personal computers. It is not available for Microsoft Windows PCs. The SDK contains sets giving developers access to various functions and services of iOS devices, such as hardware and software attributes. It also contains an iPhone simulator to mimic the look and feel of the device on the computer while developing. New versions of the SDK accompany new versions of iOS. In order to test applications, get technical support, and distribute apps through App Store, developers are required to subscribe to the Apple Developer Program. Combined with Xcode, the iOS SDK helps developers write iOS apps using officially supported programming languages, including Swift and Objective-C. Other companies have also created tools that allow for the development of native iOS apps using their respective programming languages. == History == While originally developing iPhone prior to its unveiling in 2007, Apple's then-CEO Steve Jobs did not intend to let third-party developers build native apps for the iOS operating system, instead directing them to make web applications for the Safari web browser. However, backlash from developers prompted the company to reconsider, with Jobs announcing on October 17, 2007, that Apple would have a software development kit (SDK) available for developers by February 2008. The SDK was released on March 6, 2008. == Features == The iOS SDK is a free download for Mac users. It is not available for Microsoft Windows. To test the application, get technical support, and distribute applications through App Store, developers are required to subscribe to the Apple Developer Program. The SDK contents are separated into the following sets: UIKit Multi-touch events and controls Accelerometer support View hierarchy Localization (i18n) Camera support Media OpenAL audio mixing and recording Video playback Image file formats Quartz Core Animation OpenGL ES Core Services Networking Embedded SQLite database Core Location Threads CoreMotion Mac OS X Kernel TCP/IP Sockets Power management File system Security The SDK also contains an iPhone simulator, a program used to simulate the look and feel of iPhone on the developer's computer. New SDK versions accompany new iOS versions. == Programming languages == The iOS SDK, combined with Xcode, helps developers write iOS applications using officially supported programming languages, including Swift and Objective-C. An .ipa (iOS App Store Package) file is an iOS application archive file which stores an iOS app. === Java === In 2008, Sun Microsystems announced plans to release a Java Virtual Machine (JVM) for iOS, based on the Java Platform, Micro Edition version of Java. This would enable Java applications to run on iPhone and iPod Touch. Soon after the announcement, developers familiar with the SDK's terms of agreement believed that by not allowing third-party applications to run in the background (answer a phone call and still run the application, for example), and not allowing an application to download code from another source, nor allowing an application to interact with a third-party application, Sun's development efforts could be hindered without Apple's cooperation. Sun also worked with a third-party company called Innaworks in attempts to get Java on iPhone. Despite the apparent lack of interest from Apple, a firmware leak of the 2007 iPhone release revealed an ARM chip with a processor with Jazelle support for embedded Java execution. === .NET === Novell announced in September 2009 that they had successfully developed MonoTouch, a software framework that let developers write native iPhone applications in the C# and .NET programming languages, while still maintaining compatibility with Apple's requirements. === Flash === iOS does not support Adobe Flash, and although Adobe has two versions of its software: Flash and Flash Lite, Apple views neither as suitable for the iPhone, claiming that full Flash is "too slow to be useful", and Flash Lite to be "not capable of being used with the Web". In October 2009, Adobe announced that an upcoming update to its Creative Suite would feature a component to let developers build native iPhone apps using the company's Flash development tools. The software was officially released as part of the company's Creative Suite 5 collection of professional applications. === 2010 policy on development tools === In April 2010, Apple made controversial changes to its iPhone Developer Agreement, requiring developers to use only "approved" programming languages in order to publish apps on App Store, and banning applications that used third-party development tools; the ban affected Adobe's Packager tool, which converted Flash apps into iOS apps. After developer backlash and news of a potential anti-trust investigation, Apple again revised its agreement in September, allowing the use of third-party development tools. === Mac Catalyst === Originally called "Project Marzipan", Mac Catalyst helps developers bring iPadOS app experiences to macOS, and make it easier to take apps developed for iPadOS devices to Macs by avoiding the need to write the underlying software code twice.

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  Accumulated local effects

  Accumulated local effects (ALE) is a machine learning interpretability method. == Concepts == ALE uses a conditional feature distribution as an input and generates augmented data, creating more realistic data than a marginal distribution. It ignores far out-of-distribution (outlier) values. Unlike partial dependence plots and marginal plots, ALE is not defeated in the presence of correlated predictors. It analyzes differences in predictions instead of averaging them by calculating the average of the differences in model predictions over the augmented data, instead of the average of the predictions themselves. == Example == Given a model that predicts house prices based on its distance from city center and size of the building area, ALE compares the differences of predictions of houses of different sizes. The result separates the impact of the size from otherwise correlated features. == Limitations == Defining evaluation windows is subjective. High correlations between features can defeat the technique. ALE requires more and more uniformly distributed observations than PDP so that the conditional distribution can be reliably determined. The technique may produce inadequate results if the data is highly sparse, which is more common with high-dimensional data (curse of dimensionality).

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  Linguamatics

  Linguamatics, headquartered in Cambridge, England, with offices in the United States and UK, is a provider of text mining systems through software licensing and services, primarily for pharmaceutical and healthcare applications. Founded in 2001, the company was purchased by IQVIA in January 2019. == Technology == The company develops enterprise search tools for the life sciences sector. The core natural language processing engine (I2E) uses a federated architecture to incorporate data from 3rd party resources. Initially developed to be used interactively through a graphic user interface, the core software also has an application programming interface that can be used to automate searches. LabKey, Penn Medicine, Atrius Health and Mercy all use Linguamatics software to extract electronic health record data into data warehouses. Linguamatics software is used by 17 of the top 20 global pharmaceutical companies, the US Food and Drug Administration, as well as healthcare providers. == Software community == The core software, "I2E", is used by a number of companies to either extend their own software or to publish their data. Copyright Clearance Center uses I2E to produce searchable indexes of material that would otherwise be unsearchable due to copyright. Thomson Reuters produces Cortellis Informatics Clinical Text Analytics, which depends on I2E to make clinical data accessible and searchable. Pipeline Pilot can integrate I2E as part of a workflow. ChemAxon can be used alongside I2E to allow named entity recognition of chemicals within unstructured data. Data sources include MEDLINE, ClinicalTrials.gov, FDA Drug Labels, PubMed Central, and Patent Abstracts.

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  GNU Octave

  GNU Octave is a scientific programming language for scientific computing and numerical computation. Among other things, Octave can be used to solve linear and nonlinear problems numerically and to perform other numerical experiments using a language that is mostly compatible with MATLAB. It may also be used as a batch-oriented language. As part of the GNU Project, it is free software under the terms of the GNU General Public License. == History == The project was conceived around 1988. At first it was intended to be a companion to a chemical reactor design course. Full development was started by John W. Eaton in 1992. The first alpha release dates back to 4 January 1993 and on 17 February 1994 version 1.0 was released. Version 9.2.0 was released on 7 June 2024. The program is named after Octave Levenspiel, a former professor of the principal author. Levenspiel was known for his ability to perform quick back-of-the-envelope calculations. == Development history == == Developments == In addition to use on desktops for personal scientific computing, Octave is used in academia and industry. For example, Octave was used on a massive parallel computer at Pittsburgh Supercomputing Center to find vulnerabilities related to guessing social security numbers. Acceleration with OpenCL or CUDA is also possible with use of GPUs. == Technical details == Octave is written in C++ using the C++ standard library. Octave uses an interpreter to execute the Octave scripting language. Octave is extensible using dynamically loadable modules. Octave interpreter has an OpenGL-based graphics engine to create plots, graphs and charts and to save or print them. Alternatively, gnuplot can be used for the same purpose. Octave includes a graphical user interface (GUI) in addition to the traditional command-line interface (CLI); see #User interfaces for details. == Octave, the language == The Octave language is an interpreted programming language. It is a structured programming language (similar to C) and supports many common C standard library functions, and also certain UNIX system calls and functions. However, it does not support passing arguments by reference although function arguments are copy-on-write to avoid unnecessary duplication. Octave programs consist of a list of function calls or a script. The syntax is matrix-based and provides various functions for matrix operations. It supports various data structures and allows object-oriented programming. Its syntax is very similar to MATLAB, and careful programming of a script will allow it to run on both Octave and MATLAB. Because Octave is made available under the GNU General Public License, it may be freely changed, copied and used. The program runs on Microsoft Windows and most Unix and Unix-like operating systems, including Linux, Android, and macOS. == Notable features == === Command and variable name completion === Typing a TAB character on the command line causes Octave to attempt to complete variable, function, and file names (similar to Bash's tab completion). Octave uses the text before the cursor as the initial portion of the name to complete. === Command history === When running interactively, Octave saves the commands typed in an internal buffer so that they can be recalled and edited. === Data structures === Octave includes a limited amount of support for organizing data in structures. In this example, we see a structure x with elements a, b, and c, (an integer, an array, and a string, respectively): === Short-circuit Boolean operators === Octave's && and || logical operators are evaluated in a short-circuit fashion (like the corresponding operators in the C language), in contrast to the element-by-element operators & and |. === Increment and decrement operators === Octave includes the C-like increment and decrement operators ++ and -- in both their prefix and postfix forms. Octave also does augmented assignment, e.g. x += 5. === Unwind-protect === Octave supports a limited form of exception handling modelled after the unwind_protect of Lisp. The general form of an unwind_protect block looks like this: As a general rule, GNU Octave recognizes as termination of a given block either the keyword end (which is compatible with the MATLAB language) or a more specific keyword endblock or, in some cases, end_block. As a consequence, an unwind_protect block can be terminated either with the keyword end_unwind_protect as in the example, or with the more portable keyword end. The cleanup part of the block is always executed. In case an exception is raised by the body part, cleanup is executed immediately before propagating the exception outside the block unwind_protect. GNU Octave also supports another form of exception handling (compatible with the MATLAB language): This latter form differs from an unwind_protect block in two ways. First, exception_handling is only executed when an exception is raised by body. Second, after the execution of exception_handling the exception is not propagated outside the block (unless a rethrow( lasterror ) statement is explicitly inserted within the exception_handling code). === Variable-length argument lists === Octave has a mechanism for handling functions that take an unspecified number of arguments without explicit upper limit. To specify a list of zero or more arguments, use the special argument varargin as the last (or only) argument in the list. varargin is a cell array containing all the input arguments. === Variable-length return lists === A function can be set up to return any number of values by using the special return value varargout. For example: === C++ integration === It is also possible to execute Octave code directly in a C++ program. For example, here is a code snippet for calling rand([10,1]): C and C++ code can be integrated into GNU Octave by creating oct files, or using the MATLAB compatible MEX files. == MATLAB compatibility == Octave has been built with MATLAB compatibility in mind, and shares many features with MATLAB: % Script: myscript.m a = 5; b = a 2 % Function: myfunc.m function result = myfunc(x) result = x^2 + 3; end Matrices as fundamental data type. Built-in support for complex numbers. Powerful built-in math functions and extensive function libraries. Extensibility in the form of user-defined functions. Octave treats incompatibility with MATLAB as a bug; therefore, it could be considered a software clone, which does not infringe software copyright as per Lotus v. Borland court case. MATLAB scripts from the MathWorks' FileExchange repository in principle are compatible with Octave. However, while they are often provided and uploaded by users under an Octave compatible and proper open source BSD license, the FileExchange Terms of use prohibit any usage beside MathWorks' proprietary MATLAB. === Syntax compatibility === There are a few purposeful, albeit minor, syntax additions Archived 2012-04-26 at the Wayback Machine: Comment lines can be prefixed with the # character as well as the % character; Various C-based operators ++, --, +=, =, /= are supported; Elements can be referenced without creating a new variable by cascaded indexing, e.g. [1:10](3); Strings can be defined with the double-quote " character as well as the single-quote ' character; When the variable type is single (a single-precision floating-point number), Octave calculates the "mean" in the single-domain (MATLAB in double-domain) which is faster but gives less accurate results; Blocks can also be terminated with more specific Control structure keywords, i.e., endif, endfor, endwhile, etc.; Functions can be defined within scripts and at the Octave prompt; Presence of a do-until loop (similar to do-while in C). === Function compatibility === Many, but not all, of the numerous MATLAB functions are available in GNU Octave, some of them accessible through packages in Octave Forge. The functions available as part of either core Octave or Forge packages are listed online Archived 2024-03-14 at the Wayback Machine. A list of unavailable functions is included in the Octave function __unimplemented.m__. Unimplemented functions are also listed under many Octave Forge packages in the Octave Wiki. When an unimplemented function is called the following error message is shown: == User interfaces == Octave comes with an official graphical user interface (GUI) and an integrated development environment (IDE) based on Qt. It has been available since Octave 3.8, and has become the default interface (over the command-line interface) with the release of Octave 4.0. It was well-received by an EDN contributor, who wrote "[Octave] now has a very workable GUI" in reviewing the then-new GUI in 2014. Several 3rd-party graphical front-ends have also been developed, like ToolboX for coding education. == GUI applications == With Octave code, the user can create GUI applications. See GUI Development (GNU Octave (version 7.1.0)). Below are some examples: Button, edit control, checkboxTextboxListbox wit

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  Syman

  SYMAN is an artificial intelligence technology that uses data from social media profiles to identify trends in the job market. SYMAN is designed to organize actionable data for products and services including recruiting, human capital management, CRM, and marketing. SYMAN was developed with a $21 million series B financing round secured by Identified, which was led by VantagePoint Capital Partners and Capricorn Investment Group.

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  Winner-take-all (computing)

  Winner-take-all is a computational principle applied in computational models of neural networks by which neurons compete with each other for activation. In the classical form, only the neuron with the highest activation stays active while all other neurons shut down; however, other variations allow more than one neuron to be active, for example the soft winner take-all, by which a power function is applied to the neurons. == Neural networks == In the theory of artificial neural networks, winner-take-all networks are a case of competitive learning in recurrent neural networks. Output nodes in the network mutually inhibit each other, while simultaneously activating themselves through reflexive connections. After some time, only one node in the output layer will be active, namely the one corresponding to the strongest input. Thus the network uses nonlinear inhibition to pick out the largest of a set of inputs. Winner-take-all is a general computational primitive that can be implemented using different types of neural network models, including both continuous-time and spiking networks. Winner-take-all networks are commonly used in computational models of the brain, particularly for distributed decision-making or action selection in the cortex. Important examples include hierarchical models of vision, and models of selective attention and recognition. They are also common in artificial neural networks and neuromorphic analog VLSI circuits. It has been formally proven that the winner-take-all operation is computationally powerful compared to other nonlinear operations, such as thresholding. In many practical cases, there is not only one single neuron which becomes active but there are exactly k neurons which become active for a fixed number k. This principle is referred to as k-winners-take-all. === Example algorithm === Consider a single linear neuron, with inputs x 1 , … , x n {\displaystyle x_{1},\dots ,x_{n}} . Each input has weight w i {\displaystyle w_{i}} , and the output of the neuron is ∑ i w i x i {\displaystyle \sum _{i}w_{i}x_{i}} . In the Instar learning rule, on each input vector, the weight vectors are modified according to Δ w i = η ( x i − w i ) {\displaystyle \Delta w_{i}=\eta (x_{i}-w_{i})} where η {\displaystyle \eta } is the learning rate. This rule is unsupervised, since we need just the input vector, not a reference output. Now, consider multiple linear neurons y 1 , … , y m {\displaystyle y_{1},\dots ,y_{m}} . The output of each satisfies y i = ∑ j w i j x j {\displaystyle y_{i}=\sum _{j}w_{ij}x_{j}} . In the winner-take-all algorithm, the weights are modified as follows. Given an input vector x {\displaystyle x} , each output is computed. The neuron with the largest output is selected, and the weights going into that neuron are modified according to the Instar learning rule. All other weights remain unchanged. The k-winners-take-all rule is similar, except that the Instar learning rule is applied to the weights going into the k neurons with the largest outputs. == Circuit example == A simple, but popular CMOS winner-take-all circuit is shown on the right. This circuit was originally proposed by Lazzaro et al. (1989) using MOS transistors biased to operate in the weak-inversion or subthreshold regime. In the particular case shown there are only two inputs (IIN,1 and IIN,2), but the circuit can be easily extended to multiple inputs in a straightforward way. It operates on continuous-time input signals (currents) in parallel, using only two transistors per input. In addition, the bias current IBIAS is set by a single global transistor that is common to all the inputs. The largest of the input currents sets the common potential VC. As a result, the corresponding output carries almost all the bias current, while the other outputs have currents that are close to zero. Thus, the circuit selects the larger of the two input currents, i.e., if IIN,1 > IIN,2, we get IOUT,1 = IBIAS and IOUT,2 = 0. Similarly, if IIN,2 > IIN,1, we get IOUT,1 = 0 and IOUT,2 = IBIAS. A SPICE-based DC simulation of the CMOS winner-take-all circuit in the two-input case is shown on the right. As shown in the top subplot, the input IIN,1 was fixed at 6nA, while IIN,2 was linearly increased from 0 to 10nA. The bottom subplot shows the two output currents. As expected, the output corresponding to the larger of the two inputs carries the entire bias current (10nA in this case), forcing the other output current nearly to zero. == Other uses == In stereo matching algorithms, following the taxonomy proposed by Scharstein and Szelliski, winner-take-all is a local method for disparity computation. Adopting a winner-take-all strategy, the disparity associated with the minimum or maximum cost value is selected at each pixel. It is axiomatic that in the electronic commerce market, early dominant players such as AOL or Yahoo! get most of the rewards. By 1998, one study found the top 5% of all web sites garnered more than 74% of all traffic. The winner-take-all hypothesis in economics suggests that once a technology or a firm gets ahead, it will do better and better over time, whereas lagging technology and firms will fall further behind. See First-mover advantage.

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  Evolutionary programming

  Evolutionary programming is an evolutionary algorithm, where a share of new population is created by mutation of previous population without crossover. Evolutionary programming differs from evolution strategy ES( μ + λ {\displaystyle \mu +\lambda } ) in one detail. All individuals are selected for the new population, while in ES( μ + λ {\displaystyle \mu +\lambda } ), every individual has the same probability to be selected. It is one of the four major evolutionary algorithm paradigms. == History == It was first used by Lawrence J. Fogel in the US in 1960 in order to use simulated evolution as a learning process aiming to generate artificial intelligence. It was used to evolve finite-state machines as predictors.

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  Premature convergence

  Premature convergence is an unwanted effect in evolutionary algorithms (EA), a metaheuristic that mimics the basic principles of biological evolution as a computer algorithm for solving an optimization problem. The effect means that the population of an EA has converged too early, resulting in being suboptimal. In this context, the parental solutions, through the aid of genetic operators, are not able to generate offspring that are superior to, or outperform, their parents. Premature convergence is a common problem found in evolutionary algorithms, as it leads to a loss, or convergence of, a large number of alleles, subsequently making it very difficult to search for a specific gene in which the alleles were present. An allele is considered lost if, in a population, a gene is present, where all individuals are sharing the same value for that particular gene. An allele is, as defined by De Jong, considered to be a converged allele, when 95% of a population share the same value for a certain gene. == Strategies for preventing premature convergence == Strategies to regain genetic variation can be: a mating strategy called incest prevention, uniform crossover, mimicking sexual selection, favored replacement of similar individuals (preselection or crowding), segmentation of individuals of similar fitness (fitness sharing), increasing population size niche and specie The genetic variation can also be regained by mutation though this process is highly random. A general strategy to reduce the risk of premature convergence is to use structured populations instead of the commonly used panmictic ones. == Identification of the occurrence of premature convergence == It is hard to determine when premature convergence has occurred, and it is equally hard to predict its presence in the future. One measure is to use the difference between the average and maximum fitness values, as used by Patnaik & Srinivas, to then vary the crossover and mutation probabilities. Population diversity is another measure which has been extensively used in studies to measure premature convergence. However, although it has been widely accepted that a decrease in the population diversity directly leads to premature convergence, there have been little studies done on the analysis of population diversity. In other words, by using the term population diversity, the argument for a study in preventing premature convergence lacks robustness, unless specified what their definition of population diversity is. There are models to counter the effect and risk of premature convergence that do not compromise core GA parameters like population size, mutation rate, and other core mechanisms. These models were inspired by biological ecology, where genetic interactions are limited by external mechanisms such as spatial topologies or speciation. These ecological models, such as the Eco-GA, adopt diffusion-based strategies to improve the robustness of GA runs and increase the likelihood of reaching near-global optima. == Causes for premature convergence == There are a number of presumed or hypothesized causes for the occurrence of premature convergence. === Self-adaptive mutations === Rechenberg introduced the idea of self-adaptation of mutation distributions in evolution strategies. According to Rechenberg, the control parameters for these mutation distributions evolved internally through self-adaptation, rather than predetermination. He called it the 1/5-success rule of evolution strategies (1 + 1)-ES: The step size control parameter would be increased by some factor if the relative frequency of positive mutations through a determined period of time is larger than 1/5, vice versa if it is smaller than 1/5. Self-adaptive mutations may very well be one of the causes for premature convergence. Accurately locating of optima can be enhanced by self-adaptive mutation, as well as accelerating the search for this optima. This has been widely recognized, though the mechanism's underpinnings of this have been poorly studied, as it is often unclear whether the optima is found locally or globally. Self-adaptive methods can cause global convergence to global optimum, provided that the selection methods used are using elitism, as well as that the rule of self-adaptation doesn't interfere with the mutation distribution, which has the property of ensuring a positive minimum probability when hitting a random subset. This is for non-convex objective functions with sets that include bounded lower levels of non-zero measurements. A study by Rudolph suggests that self-adaption mechanisms among elitist evolution strategies do resemble the 1/5-success rule, and could very well get caught by a local optimum that include a positive probability. === Panmictic populations === Most EAs use unstructured or panmictic populations where basically every individual in the population is eligible for mate selection based on fitness. Thus, The genetic information of an only slightly better individual can spread in a population within a few generations, provided that no better other offspring is produced during this time. Especially in comparatively small populations, this can quickly lead to a loss of genotypic diversity and thus to premature convergence. A well-known countermeasure is to switch to alternative population models which introduce substructures into the population that preserve genotypic diversity over a longer period of time and thus counteract the tendency towards premature convergence. This has been shown for various EAs such as genetic algorithms, the evolution strategy, other EAs or memetic algorithms.

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  Zero-shot learning

  Zero-shot learning (ZSL) is a problem setup in deep learning where, at test time, a learner observes samples from classes which were not observed during training, and needs to predict the class that they belong to. The name is a play on words based on the earlier concept of one-shot learning, in which classification can be learned from only one, or a few, examples. Zero-shot methods generally work by associating observed and non-observed classes through some form of auxiliary information, which encodes observable distinguishing properties of objects. For example, given a set of images of animals to be classified, along with auxiliary textual descriptions of what animals look like, an artificial intelligence model which has been trained to recognize horses, but has never been given a zebra, can still recognize a zebra when it also knows that zebras look like striped horses. This problem is widely studied in computer vision, natural language processing, and machine perception. == Background and history == The first paper on zero-shot learning in natural language processing appeared in a 2008 paper by Chang, Ratinov, Roth, and Srikumar, at the AAAI'08, but the name given to the learning paradigm there was dataless classification. The first paper on zero-shot learning in computer vision appeared at the same conference, under the name zero-data learning. The term zero-shot learning itself first appeared in the literature in a 2009 paper from Palatucci, Hinton, Pomerleau, and Mitchell at NIPS'09. This terminology was repeated later in another computer vision paper and the term zero-shot learning caught on, as a take-off on one-shot learning that was introduced in computer vision years earlier. In computer vision, zero-shot learning models learned parameters for seen classes along with their class representations and rely on representational similarity among class labels so that, during inference, instances can be classified into new classes. In natural language processing, the key technical direction developed builds on the ability to "understand the labels"—represent the labels in the same semantic space as that of the documents to be classified. This supports the classification of a single example without observing any annotated data, the purest form of zero-shot classification. The original paper made use of the Explicit Semantic Analysis (ESA) representation but later papers made use of other representations, including dense representations. This approach was also extended to multilingual domains, fine entity typing and other problems. Moreover, beyond relying solely on representations, the computational approach has been extended to depend on transfer from other tasks, such as textual entailment and question answering. The original paper also points out that, beyond the ability to classify a single example, when a collection of examples is given, with the assumption that they come from the same distribution, it is possible to bootstrap the performance in a semi-supervised like manner (or transductive learning). Unlike standard generalization in machine learning, where classifiers are expected to correctly classify new samples to classes they have already observed during training, in ZSL, no samples from the classes have been given during training the classifier. It can therefore be viewed as an extreme case of domain adaptation. == Prerequisite information for zero-shot classes == Naturally, some form of auxiliary information has to be given about these zero-shot classes, and this type of information can be of several types. Learning with attributes: classes are accompanied by pre-defined structured description. For example, for bird descriptions, this could include "red head", "long beak". These attributes are often organized in a structured compositional way, and taking that structure into account improves learning. While this approach was used mostly in computer vision, there are some examples for it also in natural language processing. Learning from textual description. As pointed out above, this has been the key direction pursued in natural language processing. Here class labels are taken to have a meaning and are often augmented with definitions or free-text natural-language description. This could include for example a wikipedia description of the class. Class-class similarity. Here, classes are embedded in a continuous space. A zero-shot classifier can predict that a sample corresponds to some position in that space, and the nearest embedded class is used as a predicted class, even if no such samples were observed during training. == Generalized zero-shot learning == The above ZSL setup assumes that at test time, only zero-shot samples are given, namely, samples from new unseen classes. In generalized zero-shot learning, samples from both new and known classes, may appear at test time. This poses new challenges for classifiers at test time, because it is very challenging to estimate if a given sample is new or known. Some approaches to handle this include: a gating module, which is first trained to decide if a given sample comes from a new class or from an old one, and then, at inference time, outputs either a hard decision, or a soft probabilistic decision a generative module, which is trained to generate feature representation of the unseen classes—a standard classifier can then be trained on samples from all classes, seen and unseen. == Domains of application == Zero shot learning has been applied to the following fields: image classification semantic segmentation image generation object detection natural language processing computational biology abstract reasoning

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  Synaptic weight

  In neuroscience and computer science, synaptic weight refers to the strength or amplitude of a connection between two nodes, corresponding in biology to the amount of influence the firing of one neuron has on another. The term is typically used in artificial and biological neural network research. == Computation == In a computational neural network, a vector or set of inputs x {\displaystyle {\textbf {x}}} and outputs y {\displaystyle {\textbf {y}}} , or pre- and post-synaptic neurons respectively, are interconnected with synaptic weights represented by the matrix w {\displaystyle w} , where for a linear neuron y j = ∑ i w i j x i or y = w x {\displaystyle y_{j}=\sum _{i}w_{ij}x_{i}~~{\textrm {or}}~~{\textbf {y}}=w{\textbf {x}}} . where the rows of the synaptic matrix represent the vector of synaptic weights for the output indexed by j {\displaystyle j} . The synaptic weight is changed by using a learning rule, the most basic of which is Hebb's rule, which is usually stated in biological terms as Neurons that fire together, wire together. Computationally, this means that if a large signal from one of the input neurons results in a large signal from one of the output neurons, then the synaptic weight between those two neurons will increase. The rule is unstable, however, and is typically modified using such variations as Oja's rule, radial basis functions or the backpropagation algorithm. == Biology == For biological networks, the effect of synaptic weights is not as simple as for linear neurons or Hebbian learning. However, biophysical models such as BCM theory have seen some success in mathematically describing these networks. In the mammalian central nervous system, signal transmission is carried out by interconnected networks of nerve cells, or neurons. For the basic pyramidal neuron, the input signal is carried by the axon, which releases neurotransmitter chemicals into the synapse which is picked up by the dendrites of the next neuron, which can then generate an action potential which is analogous to the output signal in the computational case. The synaptic weight in this process is determined by several variable factors: How well the input signal propagates through the axon (see myelination), The amount of neurotransmitter released into the synapse and the amount that can be absorbed in the following cell (determined by the number of AMPA and NMDA receptors on the cell membrane and the amount of intracellular calcium and other ions), The number of such connections made by the axon to the dendrites, How well the signal propagates and integrates in the postsynaptic cell. The changes in synaptic weight that occur is known as synaptic plasticity, and the process behind long-term changes (long-term potentiation and depression) is still poorly understood. Hebb's original learning rule was originally applied to biological systems, but has had to undergo many modifications as a number of theoretical and experimental problems came to light.

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  Neural Networks (journal)

  Neural Networks is a monthly peer-reviewed scientific journal and an official journal of the International Neural Network Society, European Neural Network Society, and Japanese Neural Network Society. == History == The journal was established in 1988 and is published by Elsevier. It covers all aspects of research on artificial neural networks. The founding editor-in-chief was Stephen Grossberg (Boston University). The current editors-in-chief are DeLiang Wang (Ohio State University) and Taro Toyoizumi (RIKEN Center for Brain Science). == Abstracting and indexing == The journal is abstracted and indexed in Scopus and the Science Citation Index Expanded. According to the Journal Citation Reports, the journal has a 2022 impact factor of 7.8.

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