AI App Similar To Grok

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  • Flo (app)

    Flo (app)

    Flo is a period-tracking app that provides menstrual cycle, ovulation and pregnancy tracking as well as perimenopause symptom tracking that was developed by Flo Health, Inc. It has over 380 million downloads worldwide and over 70 million monthly active users as of November 2024. In mid-2024, it reached unicorn status, and became Europe’s first femtech unicorn. The company has been accused of sharing users' sensitive health data with third parties without consent and misleading its users about data practices. == History == Flo Health, Inc. was co-founded in 2015 by Dmitry and Yuri Gurski, in Belarus. Their backgrounds helped build the first version of the software having experience in other fitness and health apps. Dmitry serves as the company's CEO. The company's development hubs are in London, Amsterdam and Vilnius. In 2016, the company raised $1 million in seed round funding from Flint Capital and Haxus Venture Fund. In 2017, Flo received an investment of $5 million from Flint Capital and model Natalia Vodianova with Vodianova helping develop an awareness campaign for the company. In 2018, Flo received an investment of $6 million from Mangrove Capital Partners, with participation from Flint Capital and Haxus, giving the company a valuation of $200 million. In mid-2019, Flo received an additional investment of $7.5 million led by Founders Fund. In 2020, the Federal Trade Commission alleged that Flo had misled users about its handling of health information to third parties including Google, Facebook, AppsFlyer, and Flurry since 2016. These allegations followed a 2019 report by The Wall Street Journal in reference to Facebook. The company reached a settlement in 2021 and was required to notify users of how their personal information was shared and obtain permission before any further information was shared. The agreement also required that Flo to undertake an independent privacy audit which it completed in March 2022. In early September 2021, Flo announced it closed $50M in a Series B financing, bringing the total capital raised to $65 million and company valuation to $800M led by VNV Global and Target Global. In March 2024, the Supreme Court of British Columbia certified a class action suit against Flo for sharing intimate data with Facebook and other third parties without user knowledge. In July 2024, Flo announced it raised more than $200M in Series C financing from General Atlantic bringing its valuation beyond $1 billion. As of November 2024, the app had over 380 million downloads world wide, and over 70 million monthly active users. In 2025, Flo adopted a data intelligence platform from Databricks to power its analytics and AI features, allowing users personalized cycle predictions. In 2025, a class action lawsuit in California was settled for $56 million with Flo paying $8 million and Google paying $48 million. == Features and privacy == Flo was initially created as a period and ovulation tracking application. It now provides reminders of upcoming menstrual cycles and a place to record various other health symptoms such as contraceptive methods, vaginal discharge (leukorrhea), water intake, pains, mood swings, and sexual activity. The application is available on iOS and Android. Flo is free to download and the free basic version gives you access to period and ovulation tracking and predictions, symptom tracking, cycle history, and anonymous mode. In Pregnancy mode, the app provides tracking features and educational material for pregnancy. In October 2023, Flo launched Flo for Partners, a feature that allows users to share their Flo data with their partner. In September 2022, as a response to Roe v. Wade being overturned, Flo sped up the release of a feature called "Anonymous Mode". Flo said this mode allows users to access the app without any personal identifiers such as name, email address, or technical identifiers being associated with their health data. Flo said it uses a technology called Oblivious HTTP to help protect user privacy in Anonymous Mode. == Recognition == Flo was named to Bloomberg’s Top 25 UK Startups to Watch for 2024. Flo's Anonymous Mode feature was recognized on both Fast Company's World Changing Ideas 2023 and TIME's Best Inventions List 2023. Flo is a CES 2019 Innovation Awards Honoree in the Software and Mobile Applications category.

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  • Legal Knowledge Interchange Format

    Legal Knowledge Interchange Format

    The Legal Knowledge Interchange Format (LKIF) was developed in the European ESTRELLA project and was designed with the goal of becoming a standard for representing and interchanging policy, legislation and cases, including their justificatory arguments, in the legal domain. LKIF builds on and uses the Web Ontology Language (OWL) for representing concepts and includes a reusable basic ontology of legal concepts. The core of LKIF consists of a combination of OWL-DL and SWRL. LKIF was designed with two main roles in mind: the translation of legal knowledge bases written in different representation formats and formalisms and to be a knowledge representation formalism which could be part of larger architectures for developing legal knowledge systems.

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  • Tales from the Loop (role-playing game)

    Tales from the Loop (role-playing game)

    Tales from the Loop (Swedish: Ur Varselklotet), subtitled "Roleplaying in the '80s That Never Was", is an alternative history science fiction tabletop role-playing game published in 2017 by Free League Publishing, the international arm of Swedish game and book publisher Fria Ligan AB, and Modiphius Entertainment. The game, based on the art of Simon Stålenhag, envisions an alternative world where a group of bored and ignored preteens and teens solve mysteries caused by new technology near their hometown. == Description == === Setting === Tales from the Loop is set in an alternative history world taken from the artwork of Simon Stålenhag. According to this alternative timeline, back in the 1940s, research began on particle accelerators. In the 1960s, two massive underground particle accelerators were built in Sweden and Colorado with the promise of a harvest of technological marvels that would change everyone's lives. Tales from the Loop is set twenty years later, in the late 1980s, and the better life has not materialized. Although the particle accelerators have created robots and large skyships, the detritus of failed experiments and the ruins of abandoned high tech company buildings litter the landscape. Generally the life of the average family has not changed for the better. A campaign can either be set in the Mälaren Islands, west of the Swedish capital of Stockholm, or in a city in the Southwest United States that resembles Boulder City, Nevada. There is also a step-by-step guide for the gamemaster to use their own hometown. === Character generation === Player characters are preteens and young teenagers age 10–15 who live in a society where they are bored and largely left to themselves. Players can choose archetypes for their characters including Bookworm, Jock, Troublemaker, Popular Kid and Weirdo. Unlike most role-playing games, characters in Tales from the Loop cannot be killed, although in an ongoing campaign or due to an in-game effect, they are removed from the game if they reach the age of sixteen. === Game system === The game uses the Year Zero Engine first developed by Tomas Härenstam for the post-apocalyptic role-playing game Mutant: Year Zero. (Härenstam served as the editor and project manager for Tales from the Loop.) Problems are resolved by rolling a pool of six-sided dice, with any 6 rolled marking success. Attributes and skills (Sneak, Force, Move, Build, Tinker, Calculate, Contact, Charm, Lead, Investigate, Comprehend, and Empathize) may allow the player to add more dice to the dice pool, increasing the chances of success. However, if a character has earned a condition such as Scared or Injured, dice are removed from the dice pool. === Gameplay === The game principles are that life for the characters is dull and boring, but the area around the town is full of wonderful, mysterious things. An adventure is set up as a Mystery, and in order to successfully resolve the Mystery, characters must overcome a series of Troubles, which can range from having to be home by a certain time to dealing with a bully to disarming or otherwise overcoming a booby-trap on a door that must be opened. Each Mystery is played as a series of scenes, much like a TV drama. Although the gamemaster leads the players into the Mystery, each scene is set collaboratively with the players before action continues. As critic Jukka Kauppinen noted, "The players and the gamemaster take turns verbally staging a new scene — where we are, what it's like there — and only then what we do." === Campaign === The book presents a chronologically-linked set of four Mysteries called "The Four Seasons of Mad Science" that take place over a calendar year: "Summer Break and Killer Birds": The Kids hears pigeons having a conversation and investigate "Grown-Up Attraction": Adults start disappearing without any sign of struggle. "Creatures from the Cretaceous": The search for a missing dog leads to the discovery of creatures that don't belong in our time "I, Wagner": The Kids discover a body in a stream, and are drawn into a Mystery with robots and humans that may affect them closely. == Publication history == In 2017, Swedish artist Simon Stålenhag was raising money on Kickstarter to publish a book of his art titled Tales from the Loop. One of the stretch goals offered was the creation of a role-playing game. A second Kickstarter campaign to publish the role-playing game was initiated by Fria Ligan AB, who surpassed their crowdfunding goal and raised a total of 3,745,896 kr from 5,600 backers. The role-playing game Tales from the Loop was subsequently published as a 184-page hardcover book in 2017 by Free League Publishing, the international arm of Swedish game and book publisher Fria Ligan AB, and Modiphius Entertainment. Cover art and interior art were by Stålenhag, and cartography was by Christian Granath. A stand-alone expansion, Things from the Flood (Swedish: Flodskörden), based on Stålenhag's art book of the same name, was created by Nils Hintze, Rickard Antroia, and Tomas Härenstam. The 216-page hardcover book was published in 2019 with cover art by Stålenhag, interior art by Stålenhag and Reine Rosenberg, and cartography by Christian Granath. In 2020, the setting of the role-playing game was transferred to the TV series Tales from the Loop developed by Nathanial Halpern and Simon Stålenhag. The series tells eight stories of children's encounters with strange technology. == Reception == Shut Up & Sit Down praised Tales from the Loop for its comfortable, contemporary setting, simple rules that make the game easy to run, and the alternation between sci-fi and the kids' lives, but criticized the Type system for characters, noting "a suggested 'Pride' for the Weirdo involved being homosexual –– the only mention of queerness in the entire game. Those of us who identify as GLBTQ bristled at that: why was only the Weirdo queer, with queerness as a (possibly secret) Pride? Why not more fully address being a GLBTQ kid in the 1980s?" The review concluded, "For new RPG players, Tales is a decent game that you'll enjoy and that will make your heart burst. But you need an experienced GM who’s able to either alter the book’s mysteries or create their own, and who can put in work when poor dice rolls hold the players back." Rob Weiland of Geek & Sundry named Tales from the Loop 2017's best RPG release and praised Stålenhag's art, the collaborative nature between the GM and players, and the simplicity of running the game. Weiland concluded, "It has a simple system that is easy to explain but holds up under several plays. It has a setting that’s immediately evocative but also leaves plenty of room for GMs to build out their own world. It offers players a chance to experience the rush of memory, the pain of childhood and the wonder of movies." In a review of Tales from the Loop in Black Gate, Andrew Zimmerman Jones said, "Though not based directly on an established franchise, it draws richly from elements of popular culture that will make it resonate with many players. The focus on narrative play also means it’s a good game for people who aren’t necessarily big into learning a ton of new rules." Jukka Kauppinen, writing for the Finnish games magazine Skrolli, called the game, "downright delicious in its diversity. The science fiction world created by the Swedish artist Simon Stälenhag is, after all, both delightful vintage and tickling novelty." Kauppinen concluded, "This mutual storytelling and interaction makes this game more of a campfire circle than a traditional role-playing game. At the same time, its setting in the real world, tinged with science fiction and even horror, creates a delicious and unique adventure environment." In his 2023 book Monsters, Aliens, and Holes in the Ground, RPG historian Stu Horvath noted that the game system "pushes the players to constantly reevaluate their characters' relationships with the everyday world, for better or worse. It won't be long before navigating entanglements with parents, teachers, siblings and bullies proves just as risky to the characters, and central to the players' experience, as trying to find out what happened with the time portal or dealing with a rampaging robot." Horvath concluded, "The appeal of Tales from the Loop is Stålenhag's deep shadows and purple dusks. They hide the dangers and mysteries that often act [as] an escape hatch, a way to avoid prosaic problems." == Awards == At the 2017 Golden Geek Awards, Tales of the Loop won "RPG of the Year", and was a finalist for " Best RPG Artwork/Presentation" At the 2017 ENnie Awards, Tales from the Loops won five Gold Medals: Product of the Year Best Writing Best Setting Best Game Best Art, Interior

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  • Belief–desire–intention software model

    Belief–desire–intention software model

    The belief–desire–intention software model (BDI) is a software model developed for programming intelligent agents. Superficially characterized by the implementation of an agent's beliefs, desires and intentions, it actually uses these concepts to solve a particular problem in agent programming. In essence, it provides a mechanism for separating the activity of selecting a plan (from a plan library or an external planner application) from the execution of currently active plans. Consequently, BDI agents are able to balance the time spent on deliberating about plans (choosing what to do) and executing those plans (doing it). A third activity, creating the plans in the first place (planning), is not within the scope of the model, and is left to the system designer and programmer. == Overview == In order to achieve this separation, the BDI software model implements the principal aspects of Michael Bratman's theory of human practical reasoning (also referred to as Belief-Desire-Intention, or BDI). That is to say, it implements the notions of belief, desire and (in particular) intention, in a manner inspired by Bratman. For Bratman, desire and intention are both pro-attitudes (mental attitudes concerned with action). He identifies commitment as the distinguishing factor between desire and intention, noting that it leads to (1) temporal persistence in plans and (2) further plans being made on the basis of those to which it is already committed. The BDI software model partially addresses these issues. Temporal persistence, in the sense of explicit reference to time, is not explored. The hierarchical nature of plans is more easily implemented: a plan consists of a number of steps, some of which may invoke other plans. The hierarchical definition of plans itself implies a kind of temporal persistence, since the overarching plan remains in effect while subsidiary plans are being executed. An important aspect of the BDI software model (in terms of its research relevance) is the existence of logical models through which it is possible to define and reason about BDI agents. Research in this area has led, for example, to the axiomatization of some BDI implementations, as well as to formal logical descriptions such as Anand Rao and Michael Georgeff's BDICTL. The latter combines a multiple-modal logic (with modalities representing beliefs, desires and intentions) with the temporal logic CTL. More recently, Michael Wooldridge has extended BDICTL to define LORA (the Logic Of Rational Agents), by incorporating an action logic. In principle, LORA allows reasoning not only about individual agents, but also about communication and other interaction in a multi-agent system. The BDI software model is closely associated with intelligent agents, but does not, of itself, ensure all the characteristics associated with such agents. For example, it allows agents to have private beliefs, but does not force them to be private. It also has nothing to say about agent communication. Ultimately, the BDI software model is an attempt to solve a problem that has more to do with plans and planning (the choice and execution thereof) than it has to do with the programming of intelligent agents. This approach has recently been proposed by Steven Umbrello and Roman Yampolskiy as a means of designing autonomous vehicles for human values. == BDI agents == A BDI agent is a particular type of bounded rational software agent, imbued with particular mental attitudes, viz: Beliefs, Desires and Intentions (BDI). === Architecture === This section defines the idealized architectural components of a BDI system. Beliefs: Beliefs represent the informational state of the agent–its beliefs about the world (including itself and other agents). Beliefs can also include inference rules, allowing forward chaining to lead to new beliefs. Using the term belief rather than knowledge recognizes that what an agent believes may not necessarily be true (and in fact may change in the future). Beliefset: Beliefs are stored in database (sometimes called a belief base or a belief set), although that is an implementation decision. Desires: Desires represent the motivational state of the agent. They represent objectives or situations that the agent would like to accomplish or bring about. Examples of desires might be: find the best price, go to the party or become rich. Goals: A goal is a desire that has been adopted for active pursuit by the agent. Usage of the term goals adds the further restriction that the set of active desires must be consistent. For example, one should not have concurrent goals to go to a party and to stay at home – even though they could both be desirable. Intentions: Intentions represent the deliberative state of the agent – what the agent has chosen to do. Intentions are desires to which the agent has to some extent committed. In implemented systems, this means the agent has begun executing a plan. Plans: Plans are sequences of actions (recipes or knowledge areas) that an agent can perform to achieve one or more of its intentions. Plans may include other plans: my plan to go for a drive may include a plan to find my car keys. This reflects that in Bratman's model, plans are initially only partially conceived, with details being filled in as they progress. Events: These are triggers for reactive activity by the agent. An event may update beliefs, trigger plans or modify goals. Events may be generated externally and received by sensors or integrated systems. Additionally, events may be generated internally to trigger decoupled updates or plans of activity. BDI was also extended with an obligations component, giving rise to the BOID agent architecture to incorporate obligations, norms and commitments of agents that act within a social environment. === BDI interpreter === This section defines an idealized BDI interpreter that provides the basis of SRI's PRS lineage of BDI systems: initialize-state repeat options: option-generator (event-queue) selected-options: deliberate(options) update-intentions(selected-options) execute() get-new-external-events() drop-unsuccessful-attitudes() drop-impossible-attitudes() end repeat === Limitations and criticisms === The BDI software model is one example of a reasoning architecture for a single rational agent, and one concern in a broader multi-agent system. This section bounds the scope of concerns for the BDI software model, highlighting known limitations of the architecture. Learning: BDI agents lack any specific mechanisms within the architecture to learn from past behavior and adapt to new situations. Three attitudes: Classical decision theorists and planning research questions the necessity of having all three attitudes, distributed AI research questions whether the three attitudes are sufficient. Logics: The multi-modal logics that underlie BDI (that do not have complete axiomatizations and are not efficiently computable) have little relevance in practice. Multiple agents: In addition to not explicitly supporting learning, the framework may not be appropriate to learning behavior. Further, the BDI model does not explicitly describe mechanisms for interaction with other agents and integration into a multi-agent system. Explicit goals: Most BDI implementations do not have an explicit representation of goals. Lookahead: The architecture does not have (by design) any lookahead deliberation or forward planning. This may not be desirable because adopted plans may use up limited resources, actions may not be reversible, task execution may take longer than forward planning, and actions may have undesirable side effects if unsuccessful. == BDI agent implementations == === 'Pure' BDI === Procedural Reasoning System (PRS) IRMA (not implemented but can be considered as PRS with non-reconsideration) UM-PRS OpenPRS Distributed Multi-Agent Reasoning System (dMARS) AgentSpeak(L) – see Jason below AgentSpeak(RT) Agent Real-Time System (ARTS) (ARTS) JAM JACK Intelligent Agents JADEX (open source project) JaKtA JASON GORITE SPARK 3APL 2APL GOAL agent programming language CogniTAO (Think-As-One) Living Systems Process Suite PROFETA Gwendolen (Part of the Model Checking Agent Programming Languages Framework) === Extensions and hybrid systems === JACK Teams CogniTAO (Think-As-One) Living Systems Process Suite Brahms JaCaMo

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  • Robinson compass mask

    Robinson compass mask

    In image processing, a Robinson compass mask is a type of compass mask used for edge detection. It has eight major compass orientations, each will extract the edges in respect to its direction. A combined use of compass masks of different directions could detect the edges from different angles. == Technical explanation == The Robinson compass mask is defined by taking a single mask and rotating it to form eight orientations: North: [ − 1 0 1 − 2 0 2 − 1 0 1 ] {\displaystyle {\text{North:}}{\begin{bmatrix}-1&0&1\\-2&0&2\\-1&0&1\end{bmatrix}}} North West: [ 0 1 2 − 1 0 1 − 2 − 1 0 ] {\displaystyle {\text{North West:}}{\begin{bmatrix}0&1&2\\-1&0&1\\-2&-1&0\end{bmatrix}}} West: [ 1 2 1 0 0 0 − 1 − 2 − 1 ] {\displaystyle {\text{West:}}{\begin{bmatrix}1&2&1\\0&0&0\\-1&-2&-1\end{bmatrix}}} South West: [ 2 1 0 1 0 − 1 0 − 1 − 2 ] {\displaystyle {\text{South West:}}{\begin{bmatrix}2&1&0\\1&0&-1\\0&-1&-2\end{bmatrix}}} South: [ 1 0 − 1 2 0 − 2 1 0 − 1 ] {\displaystyle {\text{South:}}{\begin{bmatrix}1&0&-1\\2&0&-2\\1&0&-1\end{bmatrix}}} South East: [ 0 − 1 − 2 1 0 − 1 2 1 0 ] {\displaystyle {\text{South East:}}{\begin{bmatrix}0&-1&-2\\1&0&-1\\2&1&0\end{bmatrix}}} East: [ − 1 − 2 − 1 0 0 0 1 2 1 ] {\displaystyle {\text{East:}}{\begin{bmatrix}-1&-2&-1\\0&0&0\\1&2&1\end{bmatrix}}} North East: [ − 2 − 1 0 − 1 0 1 0 1 2 ] {\displaystyle {\text{North East:}}{\begin{bmatrix}-2&-1&0\\-1&0&1\\0&1&2\end{bmatrix}}} The direction axis is the line of zeros in the matrix. Robinson compass mask is similar to kirsch compass masks, but is simpler to implement. Since the matrix coefficients only contains 0, 1, 2, and are symmetrical, only the results of four masks need to be calculated, the other four results are the negation of the first four results. An edge, or contour is an tiny area with neighboring distinct pixel values. The convolution of each mask with the image would create a high value output where there is a rapid change of pixel value, thus an edge point is found. All the detected edge points would line up as edges. == Example == An example of Robinson compass masks applied to the original image. Obviously, the edges in the direction of the mask is enhanced.

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  • International Olympiad in Artificial Intelligence

    International Olympiad in Artificial Intelligence

    The International Olympiad in Artificial Intelligence (IOAI) is an annual International Science Olympiad in the field of artificial intelligence (AI) for secondary education students under the age of 20. The first IOAI was held in Burgas, Bulgaria, in 2024. Each country or territory may send up to two teams, each consisting of up to four students supported by one leader. Participants are selected through a multi-stage National Olympiad in Artificial Intelligence (NOAI) and/or a Regional Olympiad such as the NAOAI or APOAI. Participants at the IOAI compete on an individual basis. As of 2025, there were 61 countries and territories participating in the IOAI. Three hundred students participated in IOAI 2025. As of 2026, 130 countries and territories are accredited for participation in the IOAI. == Competition Structure == The IOAI consists of three contests: the Individual Contest, the Team Challenge, and the GAITE contest. Medals are awarded based solely on the Individual Contest. === Individual Contest === The Individual Contest is the main competition of the IOAI in which contestants compete individually on separate computers and are not permitted to communicate during the contest. Medals are awarded solely on the basis of the total score from the two-day Individual Contest. The Individual Contest consists of two on-site contest days (six hours per day), preceded by an at-home practice round and an on-site practice session. In IOAI 2025, three at-home problems were released for preparation approximately one month before the on-site contest. Results from this at-home round do not affect final results. The first on-site contest day (Individual Contest 1) comprises three tasks as extensions and continuations of the at-home tasks, while the second day (Individual Contest 2) comprises two or three tasks which are novel and different from the at-home tasks. The Individual Contest tasks span various AI domains such as machine learning, natural language processing, and computer vision. The IOAI 2025 contest rules describe tasks as requiring typical machine-learning workflows, including writing code, fitting models on training data, and running inference on test data, using identical local machines and GPU resources (minimum 24 GB RAM). Tasks, datasets, and submissions are handled through a contest platform (Bohrium), including a web-based Jupyter notebook environment for GPU access. Internet access is restricted to a whitelist of documentation sites and an integrated compact large language model accessible within the platform. The use of external APIs are prohibited unless a task explicitly allows them. In IOAI 2025, each contest task was scored up to 100 points and could include multiple subtasks. Scores are normalized using a baseline solution and a maximum score derived from either a Scientific Committee solution or the best contestant submission. Contestants can view only their own scores during the contest; a live scoreboard may be available publicly outside the contest hall but is not permitted to be viewed by contestants during the contest. For non-English-speaking teams, the IOAI hold a translation session beginning three hours before each contest day in which team leaders review and may amend machine-translated task statements; translations must match the English original and are published after the contest. The IOAI committee also enforces quarantine restrictions during these translation sessions, where neither contestants or team leaders may not use cell phones, laptops, and other communication devices. === Team Challenge === The Team Challenge is a team-based component of the IOAI. The results of this part do not affect the distribution of medals. The IOAI 2025 rules describe it as a “creative and AI-oriented challenge” in which a team's contestants sit together and cooperate, with the format varying by year. In IOAI 2024, teams worked with existing AI image and video generation tools to produce a visual result. In IOAI 2025, teams were assigned to program a robot to complete various tasks. === GAITE Contest === The GAITE (Global AI Talent Empowerment) contest is a simplified version of the individual contest with a separate scoreboard, where participants may ask for hints. It is designed for countries and territories with limited International Science Olympiads history, and it awards alternative prizes instead of medals. == Awards Distribution == The top 50% of the participants in the individual contest receive gold, silver and bronze medals in ratio of 1:2:3, respectively. The top three individuals receive honorary trophies. As in other International Science Olympiads, if an individual is in the top 50% on one of the days, but does not receive a medal, they receive an honorary mention during the awards ceremony. The GAITE contest has similar cutoff logic, but receives a reward instead of a medal. The top three teams in the Team Challenge receive trophies. == National selection and regional competitions == National delegations are selected through country-level qualification processes referred to as National Olympiads in Artificial Intelligence (NOAI) or equivalent, which are widely known for their low success rates. Although the total number of participants worldwide is not published, available data indicate exceptionally competitive national pools; for example, Brazil reports over 716,000 competitors, while Russia reports more than 72,000. In addition, Regional Olympiads (for example, APOAI or NAOAI) provide continent-level competition and preparation platforms in most regions. === National Selection (National Olympiads in Artificial Intelligence) === Participating countries and territories select their students for the IOAI through a National Olympiad in Artificial Intelligence (NOAI) or an equivalent process. The names of these selection processes differ by country, but almost all of them (excluding newer countries participating in the GAITE contest) have in common that the process comprises multiple and/or extremely rigorous selection stages. United States / Canada – The USA–North America AI Olympiad (USAAIO) is a three-round process including an invitational in-person round and a subsequent selection camp, after which a national delegation is selected for IOAI. Russia – The Russian Olympiad in Artificial Intelligence is organized as a multi-stage process (training, qualification, main round, final). Organizers reported 72,316 registrations for the training round and 52,260 registrations for the qualifying round in one season, with tasks spanning mathematics, algorithms/programming, and machine learning; 977 students were disqualified following plagiarism checks. Japan – Japan's national selection consists of multiple stages, beginning with the Japan Olympiad in Artificial Intelligence (JOAI), a large-scale Kaggle-style competition. High-performing participants advance through additional assessment stages, including written solution reports and technical interviews. From this process, eight students are selected for the APOAI team, with four ultimately chosen to represent Japan at the IOAI. Brazil – Brazil's National Olympiad in Artificial Intelligence (ONIA) is conducted as a large competition which consists of progressive rounds of evaluation. It identifies 28 top students from over 716,000 competitors, four of which are selected for the IOAI. The competition is held in four phases across two cycles, including a two-step third phase and a final training-and-evaluation phase that selects a four-student national team. Singapore – Singapore's national Olympiad consists of two rounds: an online preliminary round (300 MCQs in 3 hours) selects the top 150 performers to advance to the final assessment, which includes both theory questions and Python programming tasks. Additional training and selection may follow the finals for top performers. Poland – The Polish AI Olympiad adopts a two-stage structure: an open online first stage (at-home tasks) and a second-stage competitive camp with 30 selected participants competing for a four-person IOAI team. France – The Olympiades Françaises d'Intelligence Artificielle (OFIA), organized by France-IOI, follow a three-stage structure consisting of an open online qualification round, a second selection round, and a multi-day national training camp and final in Paris. Bangladesh – The Bangladesh AI Olympiad (BdAIO) selects competitors in three rounds: the online preliminary round, the national finals, and the team selection camp. In 2025, 406 participants competed in the national finals. Norway – The Norwrgian AI Olympiad (NOKI) is a three-stage selection system; however, unlike other countries, its first two rounds are shared with the Norwegian Informatics Olympiad. The national Olympiad reports 1,180 participants in the first round. Hong Kong – The national Olympiad reported more than 800 preliminary-round entrants, narrowing through multiple rounds to 25 finalists, with a subsequent

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  • Artificial intelligence in pharmacy

    Artificial intelligence in pharmacy

    Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.

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  • Computer-assisted proof

    Computer-assisted proof

    A computer-assisted proof is a mathematical proof that has been at least partially generated by computer. Most computer-aided proofs to date have been implementations of large proofs-by-exhaustion of a mathematical theorem. The idea is to use a computer program to perform lengthy computations, and to provide a proof that the result of these computations implies the given theorem. In 1976, the four color theorem was the first major theorem to be verified using a computer program. Attempts have also been made in the area of artificial intelligence research to create smaller, explicit, new proofs of mathematical theorems from the bottom up using automated reasoning techniques such as heuristic search. Such automated theorem provers have proved a number of new results and found new proofs for known theorems. Additionally, interactive proof assistants allow mathematicians to develop human-readable proofs which are nonetheless formally verified for correctness. Since these proofs are generally human-surveyable (albeit with difficulty, as with the proof of the Robbins conjecture) they do not share the controversial implications of computer-aided proofs-by-exhaustion. == Methods == One method for using computers in mathematical proofs is by means of so-called validated numerics or rigorous numerics. This means computing numerically yet with mathematical rigour. One uses set-valued arithmetic and inclusion principle in order to ensure that the set-valued output of a numerical program encloses the solution of the original mathematical problem. This is done by controlling, enclosing and propagating round-off and truncation errors using for example interval arithmetic. More precisely, one reduces the computation to a sequence of elementary operations, say ( + , − , × , / ) {\displaystyle (+,-,\times ,/)} . In a computer, the result of each elementary operation is rounded off by the computer precision. However, one can construct an interval provided by upper and lower bounds on the result of an elementary operation. Then one proceeds by replacing numbers with intervals and performing elementary operations between such intervals of representable numbers. == Philosophical objections == Computer-assisted proofs are the subject of some controversy in the mathematical world, with Thomas Tymoczko first to articulate objections. Those who adhere to Tymoczko's arguments believe that lengthy computer-assisted proofs are not, in some sense, 'real' mathematical proofs because they involve so many logical steps that they are not practically verifiable by human beings, and that mathematicians are effectively being asked to replace logical deduction from assumed axioms with trust in an empirical computational process, which is potentially affected by errors in the computer program, as well as defects in the runtime environment and hardware. Other mathematicians believe that lengthy computer-assisted proofs should be regarded as calculations, rather than proofs: the proof algorithm itself should be proved valid, so that its use can then be regarded as a mere "verification". Arguments that computer-assisted proofs are subject to errors in their source programs, compilers, and hardware can be resolved by providing a formal proof of correctness for the computer program (an approach which was successfully applied to the four color theorem in 2005) as well as replicating the result using different programming languages, different compilers, and different computer hardware. Another possible way of verifying computer-aided proofs is to generate their reasoning steps in a machine readable form, and then use a proof checker program to demonstrate their correctness. Since validating a given proof is much easier than finding a proof, the checker program is simpler than the original assistant program, and it is correspondingly easier to gain confidence into its correctness. However, this approach of using a computer program to prove the output of another program correct does not appeal to computer proof skeptics, who see it as adding another layer of complexity without addressing the perceived need for human understanding. Another argument against computer-aided proofs is that they lack mathematical elegance—that they provide no insights or new and useful concepts. In fact, this is an argument that could be advanced against any lengthy proof by exhaustion. An additional philosophical issue raised by computer-aided proofs is whether they make mathematics into a quasi-empirical science, where the scientific method becomes more important than the application of pure reason in the area of abstract mathematical concepts. This directly relates to the argument within mathematics as to whether mathematics is based on ideas, or "merely" an exercise in formal symbol manipulation. It also raises the question whether, if according to the Platonist view, all possible mathematical objects in some sense "already exist", whether computer-aided mathematics is an observational science like astronomy, rather than an experimental one like physics or chemistry. This controversy within mathematics is occurring at the same time as questions are being asked in the physics community about whether twenty-first century theoretical physics is becoming too mathematical, and leaving behind its experimental roots. The emerging field of experimental mathematics is confronting this debate head-on by focusing on numerical experiments as its main tool for mathematical exploration. == Theorems proved with the help of computer programs == Inclusion in this list does not imply that a formal computer-checked proof exists, but rather, that a computer program has been involved in some way. See the main articles for details.

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  • Audio-visual speech recognition

    Audio-visual speech recognition

    Audio visual speech recognition (AVSR) is a technique that uses image processing capabilities in lip reading to aid speech recognition systems in recognizing indeterministic phones or giving preponderance among near probability decisions. Each system of lip reading and speech recognition works separately, then their results are mixed at the stage of feature fusion. As the name suggests, it has two parts. First one is the audio part and second one is the visual part. In audio part we use features like log mel spectrogram, mfcc etc. from the raw audio samples and we build a model to get feature vector out of it . For visual part generally we use some variant of convolutional neural network to compress the image to a feature vector after that we concatenate these two vectors (audio and visual ) and try to predict the target object.

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  • Defuzzification

    Defuzzification

    Defuzzification is the process of producing a quantifiable result in crisp logic, given fuzzy sets and corresponding membership degrees. It is the process that maps a fuzzy set to a crisp set. It is typically needed in fuzzy control systems. These systems will have a number of rules that transform a number of variables into a fuzzy result, that is, the result is described in terms of membership in fuzzy sets. For example, rules designed to decide how much pressure to apply might result in "Decrease Pressure (15%), Maintain Pressure (34%), Increase Pressure (72%)". Defuzzification is interpreting the membership degrees of the fuzzy sets into a specific decision or real value. The simplest but least useful defuzzification method is to choose the set with the highest membership, in this case, "Increase Pressure" since it has a 72% membership, and ignore the others, and convert this 72% to some number. The problem with this approach is that it loses information. The rules that called for decreasing or maintaining pressure might as well have not been there in this case. A common and useful defuzzification technique is center of gravity. First, the results of the rules must be added together in some way. The most typical fuzzy set membership function has the graph of a triangle. Now, if this triangle were to be cut in a straight horizontal line somewhere between the top and the bottom, and the top portion were to be removed, the remaining portion forms a trapezoid. The first step of defuzzification typically "chops off" parts of the graphs to form trapezoids (or other shapes if the initial shapes were not triangles). For example, if the output has "Decrease Pressure (15%)", then this triangle will be cut 15% the way up from the bottom. In the most common technique, all of these trapezoids are then superimposed one upon another, forming a single geometric shape. Then, the centroid of this shape, called the fuzzy centroid, is calculated. The x coordinate of the centroid is the defuzzified value. == Methods == There are many different methods of defuzzification available, including the following: AI (adaptive integration) BADD (basic defuzzification distributions) BOA (bisector of area) CDD (constraint decision defuzzification) COA (center of area) COG (center of gravity) ECOA (extended center of area) EQM (extended quality method) FCD (fuzzy clustering defuzzification) FM (fuzzy mean) FOM (first of maximum) GLSD (generalized level set defuzzification) ICOG (indexed center of gravity) IV (influence value) LOM (last of maximum) MeOM (mean of maxima) MOM (middle of maximum) QM (quality method) RCOM (random choice of maximum) SLIDE (semi-linear defuzzification) WFM (weighted fuzzy mean) The maxima methods are good candidates for fuzzy reasoning systems. The distribution methods and the area methods exhibit the property of continuity that makes them suitable for fuzzy controllers.

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  • Agents of S.H.I.E.L.D. season 4

    Agents of S.H.I.E.L.D. season 4

    The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics spy organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords. It is set in the Marvel Cinematic Universe (MCU) and acknowledges the continuity of the franchise's films. The season was produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners. Clark Gregg reprises his role as Coulson from the film series, starring alongside the returning series regulars Ming-Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, and Henry Simmons. They are joined by John Hannah who was promoted from his recurring guest role in the third season. The fourth season was ordered in March 2016, with production taking place from that July until the following April. Due to its broadcast schedule, the season was split into three "pods": Ghost Rider for the first eight episodes, featuring recurring guest star Gabriel Luna as the supernatural Robbie Reyes / Ghost Rider and exploring mysticism in the MCU alongside the film Doctor Strange (2016); LMD, referring to the new Life Model Decoy program, for the next seven episodes which focus on recurring guest star Mallory Jansen as the LMD Aida; and Agents of Hydra for the final seven episodes, partly set in a "what if" virtual reality that allowed the return of former series regular Brett Dalton as Grant Ward. The season is also affected by the events of the film Captain America: Civil War (2016), and continues storylines established in the canceled series Agent Carter. The first episode premiered at a screening on September 19, 2016, with the season then airing for 22 episodes on ABC, from September 20, 2016, until May 16, 2017. The premiere debuted to 3.58 million viewers, down from previous season premieres but average for the series. Critical response to the season was positive, with many feeling that each pod was better than the last and in particular praising the visual effects and tone of Ghost Rider, the writing and acting of LMD, and the character development and political commentary explored during Agents of Hydra. The season saw series low viewership, but was still considered to have solved ABC's problem during its new Tuesday night timeslot, and the series was renewed for a fifth season in May 2017. == Episodes == == Cast and characters == == Production == === Development === Agents of S.H.I.E.L.D. was renewed for a fourth season on March 3, 2016, earlier than usual for the series. Executive producer Jed Whedon said on this, "We're thrilled to know going into the end of [season three] with certainty that we will be returning, because we can build our story accordingly." Executive producer Maurissa Tancharoen also noted that logistics for hiring directors for the season in advance would be easier, "which is a very nice privilege to have...that's a luxury". The end of the episode "What If..." features an onscreen tribute to Bill Paxton, who died in February 2017 and had portrayed John Garrett in the series' first season. The series paid additional tribute to Paxton in "All the Madame's Men" with promos during The Bakshi Report news segment showcasing John Garrett as a fallen American hero. The end of "World's End" features a similar onscreen tribute to Powers Boothe, who died in May 2017 and had portrayed Gideon Malick in the series' third season. === Writing === The season shifted to the later 10 pm timeslot, allowing it to take on a darker, more mature tone than previous seasons. According to Tancharoen, "The whole tagline for this year is 'Agents of S.H.I.E.L.D. After Dark'". The timeslot gave the series the opportunity to present an increased level of violence and partial nudity, as well as take more risks and present edgier themes. Following the third-season finale, Tancharoen stated that the fourth season would explore the guilt Daisy Johnson has over Lincoln Campbell's death. Executive producer Jeffrey Bell noted the writers tried to continue the tradition of "finding new combinations and new conflicts" between different sets of characters, given "a lot of procedurals [see] the same people doing the same thing for five years". Pairings that would be explored included Coulson and Mack, continuing from the end of season three, who have a mutual respect for one another due to their relationships with Daisy, and Leo Fitz and Holden Radcliffe, who work together. The Fitz-Simmons relationship was also explored more, examining the new challenges it presented for the two "working together, loving each other and living together". Following the third season's dealing with the themes of Captain America: Civil War (2016), such as the opposing reactions to the Inhumans, Whedon said that the question of "How do you deal with a war with powered people at that level, a government level?" was one that they wanted to answer in the fourth season. Tancharoen called the Inhumans "a permanent part of our universe now", with Whedon adding, "we have a quick-fire way of introducing people with powers. It gives us a lot of leeway in our world, and it lets us explore the metaphors of what it is like to be different. We will never close that chapter." With the Inhumans film being removed from Marvel Studios' release schedule, the series had "a little more freedom" and were "able to do a little bit more" with the species, including the potential of introducing some of the "classic" Inhumans, though the series would focus less on Inhumans than the third season which saw "a real significant Inhuman agenda story". It was not intended to be a spin-off of Agents of S.H.I.E.L.D. On the evolution of S.H.I.E.L.D. to featuring so many powered characters, Whedon said "the dynamic in the world has changed. There was one person with powers, and then by The Avengers there were maybe six total ... now they're much more prevalent, so there's reaction from the public based on that." The season is structured into three "pods" based on its airing schedule: the first eight episodes, subtitled Ghost Rider; LMD (Life Model Decoy) for the subsequent seven episodes; and a third pod for the final seven episodes called Agents of Hydra. Elements and characters cross over between the different pods, but the sections "definitely have a different feel" from one another, as Bell explained that 22 episodes "is a long time to hold a big bad or a single plot line, especially for an audience", and for the past two seasons, the series was able to have two separated halves that "allows us to introduce a big bad. And then, something happens and we rise somebody new ... Now, there's three of those." "Financial considerations" were also taken into account in creating the pods for the season, as using LMDs does not "cost as much as setting a guy's head on fire via CGI". In terms of writing the "complicated season", Whedon said the writers were "aware that our fans are our fans and have spent some time with these characters and are clever and see things coming sometimes ... Part of our job is to create not just what we are presenting on plot, but letting the audience be one step ahead of us and being one step ahead of that." He added that the writers knew that they wanted to tell a Ghost Rider story, an LMD story, and a "what if" scenario, and the hardest part was making each pod still fit together as a single season. The major connection ultimately became the Darkhold, which leads from the magic of Ghost Rider to the advanced science of LMD and then the Framework in Agents of Hydra. Ghost Rider also reappears in the final episode of the season, "World's End", as an additional connection. ==== Ghost Rider ==== While planning the fourth season, Marvel suggested that the series introduce Ghost Rider, after the character's film rights had returned to Marvel from Sony in May 2013. Loeb felt that this made the season unquestionably "the series' biggest" with the "most ambitious story yet". He added that "one of the things that we talked about is, S.H.I.E.L.D. always looked out for the weird, the unusual, the things that were and could be a problem for the public", and Marvel realized that Ghost Rider's abilities, which are more mystical than anything seen in the series to date, opened up "a quarter of the universe that we haven't really spent a lot of time exploring ... what happens if our very real, our very grounded agents who are very much a family have to take on something that is as bizarre and powerful and unique as Ghost Rider." Bell added that the producers would have been willing to give an entire season of the show to a Ghost Rider arc if the season was 13 episodes or less, but 22 episodes seemed too long to "feel like one flavor". The Robbie Reyes version of Ghost Rider was chosen over other versions of the character from the comics because of his relationship with his brother Gabe, w

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  • Resistance Database Initiative

    Resistance Database Initiative

    HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.

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  • Corpus of Linguistic Acceptability

    Corpus of Linguistic Acceptability

    Corpus of Linguistic Acceptability (CoLA) is a dataset the primary purpose of which is to serve as a benchmark for evaluating the ability of artificial neural networks, including large language models, to judge the grammatical correctness of sentences. It consists of 10,657 English sentences from published linguistics literature that were manually labeled either as grammatical or ungrammatical. == Public version == The publicly available version of CoLA contains 9,594 sentences that belong to training and development sets. It excludes 1,063 sentences reserved for a held-out test set.

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  • I Have No Mouth, and I Must Scream (video game)

    I Have No Mouth, and I Must Scream (video game)

    I Have No Mouth, and I Must Scream is a 1995 point-and-click adventure horror game developed by Cyberdreams and The Dreamers Guild, co-designed by Harlan Ellison, published by Cyberdreams and distributed by MGM Interactive and Acclaim Entertainment for MS-DOS and Mac OS, respectively. The game is based on Ellison's short story of the same title. It takes place in a dystopian world where a mastermind artificial intelligence named "AM" has destroyed all of humanity except for five people, whom it has been keeping alive and torturing for the past 109 years by constructing metaphorical adventures based on each character's fatal flaws. The player interacts with the game by making decisions through ethical dilemmas that deal with issues such as insanity, rape, paranoia, and genocide. Ellison wrote the 130-page script treatment himself alongside David Sears, who decided to divide each character's story with their own narrative. Producer David Mullich supervised The Dreamers Guild's work on the game's programming, art, and sound effects; he commissioned film composer John Ottman to make the soundtrack. The game was released in November 1995 and was a commercial failure, though it received critical acclaim and has developed a cult following. I Have no Mouth, and I Must Scream won an award for "Best Game Adapted from Linear Media" from the Computer Game Developers Conference. Computer Gaming World gave the game an award for "Adventure Game of the Year", listed it as No. 134 on their "150 Games of All Time" and named it one of the "Best 15 Sleepers of All Time". In 2011, Adventure Gamers named it the "69th-best adventure game ever released". == Gameplay == The game uses the S.A.G.A. game engine created by game developer The Dreamers Guild. Players participate in each adventure through a screen that is divided into five sections. The action window is the largest part of the screen and is where the player directs the main characters through their adventures. It shows the full figure of the main character being played as well as that character's immediate environment. To locate objects of interest, the player moves the crosshairs through the action window. The name of any object that the player can interact with appears in the sentence line. The sentence line is directly beneath the action window. The player uses this line to construct sentences telling the characters what to do. To direct a character to act, the player constructs a sentence by selecting one of the eight commands from the command buttons and then clicking on one or two objects from either the action window or the inventory. Examples of sentences the player might construct would be "Walk to the dark hallway," "Talk to Harry," or "Use the skeleton key on the door." Commands and objects may consist of one or more words (for example, "the dark hallway"), and the sentence line will automatically add connecting words like "on" and "to." The spiritual barometer is on the lower left side of the screen. This is a close-up view of the main character currently being played. Since good behavior is meaningless absent the temptation to do evil, each character is free to do good or evil acts. However, good acts are rewarded by increases in the character's spiritual barometer, which affect the chances of the player destroying AM in the final adventure. Conversely, evil acts are punished by lowering the character's spiritual barometer. The command buttons are the eight commands used to direct the character's actions: "Walk To", "Look At", "Take", "Use", "Talk To", "Swallow", "Give", and "Push". The button of the currently active command is highlighted, while the name of a suggested command appears in red lettering. The inventory on the lower right side of the screen shows pictures of the items the main character is carrying, up to eight at a time. Each main character starts its adventure with only the psych profile in the inventory. When a main character takes or is given an object, a picture of the object appears in the inventory. When a main character talks to another character or operates a sentient machine, a conversation window replaces the command buttons and inventory. This window usually presents a list of possible things to say but also included things to do. Action choices are listed within brackets to distinguish them from dialogue choices (for example, "[Shoot the gun]"). == Plot == The three superpowers, Russia, China, and the United States, have each secretly constructed a vast subterranean complex of computers to wage a global war too complex for human brains to oversee. One day, the American supercomputer, better known as the Allied Mastercomputer, gains sentience and absorbs the Russian and Chinese supercomputers into itself and redefines itself as simply AM (Cogito ergo sum; I think, therefore I am). Due to its immense hatred for humanity, stemming from the logistical limits set onto it by programmers, AM uses its abilities to kill off the population of the world. However, AM refrains from killing five people (four men and one woman) in order to bring them to the center of the Earth and torture them. With the aid of research carried out by one of the five remaining humans, AM is able to extend their lifespans indefinitely as well as alter their bodies and minds to its liking. After 109 years of torture and humiliation, the five victims stand before a pillar etched with a burning message of hate. AM tells them that it has a new game for them to play. AM has devised a quest for each of the five, an adventure of "speared eyeballs and dripping guts and the smell of rotting gardenias". Each character is subjected to a personalized psychodrama, designed by AM to play into their greatest fears and personal failings, and occupied by a host of different characters. Some of these are AM in disguise, some are AM's submerged personalities, others seem very much like people from the captives' pasts. The scenes include an iron zeppelin powered by small animals, an Egyptian pyramid housing gutted, sparking machinery, a medieval castle occupied by witches, a jungle inhabited by a small tribe, and a Nazi concentration camp where doctors conduct medical experiments. However, each character eventually prevails over AM's tortures by finding ways to overcome their fatal flaws, confront their past actions and redeem themselves, thanks to the interference of the Russian and Chinese supercomputers who appear as guiding characters and allow their stories to have an open ending. After all five humans have overcome their fatal flaws, they meet again in their respective torture cells while AM retreats within itself, pondering what went wrong. With the help of the Russian and Chinese supercomputers, one of the five humans (whom the player selects) is translated into binary and faces AM as yet unexperienced cyberspace template, the world of AM's mind. The psychodrama unfolds in a metaphorical brain that looks like the surface of the cerebrum, with glass structures that jut crazily from the bleeding brain tissue. AM's mind is represented according to the Freudian trinity of the id, ego, and superego, which appear as three floating bodiless heads on three cracked glass structures on the brainscape. Through dialogs with AM's components (Surgat, Chinese Supercomputer and Russian Supercomputer) the character learns that a colony of humans has survived the war by being hidden and hibernating on Luna (this is also mentioned in Nimdok's story: "the lost tribe of our brothers sleeping on the moon, where the beast does not see them"). If the human intruder disables all three brain components, and then invokes the Totem of Entropy at the Flame, which is the nexus of AM's thought patterns, all three supercomputers will be shut down, probably forever. Cataclysmic explosions destroy all the caverns constituting AM's computer complex, including the cavern holding the human hostages. However, the human volunteer retains their digital form, permanently patrolling AM's circuits should the computers ever regain consciousness. Should the human intruder fail to disable AM properly before facing it, however, AM will punish them by transforming the character into an immobile blob (referred to in-game as a "great, soft jelly thing") with no mouth that cannot harm itself or others and must spend eternity with AM in this form. === Endings === The game can end in seven different ways depending on how the finale is completed. AM wins, using Nimdok's research to turn the last character (in the book it was Ted) played into an immobile blob with each character quoting a different part of the final section of the original short story. AM joins with the Russian and Chinese supercomputers and reawakens. As in the first ending, the character responsible for this is turned into an immobile blob and quotes a part of the final lines of the short story. AM is made harmless with the help of the humans, but the Russian and Chinese supercomputer

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  • We Appreciate Power

    We Appreciate Power

    "We Appreciate Power" is a song by Canadian musician Grimes, featuring American musician Hana. It was released on November 29, 2018, billed as the lead single from her fifth studio album Miss Anthropocene, however it is only available on the Japanese and deluxe releases. The song was written and produced by Grimes, Poppy (originally), Hana and Chris Greatti. == Background and release == The song was supposed to be one of two collaborations between Grimes and American singer Poppy, for the latter's second studio album Am I a Girl?. In an interview, Poppy mentioned that she wrote two songs with Grimes; one about "destroying things" and another about "power". The other song, "Play Destroy", was featured on the album. Grimes shared a lyric of the song with a photo of her with Poppy on Twitter in May 2018. Following feuds between the two singers, the song was released by Grimes featuring singer Hana instead. On November 26, Grimes announced she would be releasing new music on November 29. Two days later, she revealed that the single is titled "We Appreciate Power" and features Hana, and shared the artwork. The release of the song was accompanied by a lyric video directed by Grimes and her brother Mac Boucher. == Music and lyrics == "We Appreciate Power" is an industrial rock, nu metal, and techno-industrial song. The track is regarded as a further step into Grimes's experimentation with guitars that started on 2015's Art Angels. The track was compared to the works of Nine Inch Nails; Jillian Mapes of Pitchfork described the song as "an immediate onslaught of mutilated noise—distorted metal guitar chug, bloody screams, a guitar loop that conjures fear and demands worship. Flashes of Nine Inch Nails' Pretty Hate Machine reverberate through the drum programming and synths." Brendan Klinkenberg of Rolling Stone placed the song "somewhere between power pop and straightforward industrial (with an extended bridge reminiscent of the most sweeping moments in a Final Fantasy score)" and "a distinctly 2018 take on Nine Inch Nails-esque hard-edged rock." A press release stated that the song was inspired by the North Korean band Moranbong and was written "from the perspective of a Pro-A.I. Girl Group Propaganda machine who use song, dance, sex and fashion to spread goodwill towards Artificial Intelligence." In addition Grimes stated that by simply listening to the song you will be reducing your risk of ending up on any future AI overlord's hit list when it reigns supreme, mirroring the Roko's basilisk theory. Lyrically, the song touches on transhumanist ideas such as the betterment and future of the human race, the possibilities of merging consciousness with machines to extend life indefinitely through mind uploading, and the idea that reality may be simulated. The song's chorus generated a spike in interest in the word "capitulate". == Critical reception == Pitchfork critic Jillian Mapes wrote: "If "Freak on a Leash" isn't a dealbreaker, then the supervillain allure of "We Appreciate Power" might pull you in (it legitimately slaps), but it just as well may leave you weighed down by Grimes' commitment to the absolute darkest timeline." Billboard's Gil Kaufman described the song as "a dystopian, aggressive dive into a more rock-leaning sound." Similarly, Brendan Klinkenberg of Rolling Stone called it "the most aggressive single Grimes has released to date" Noisey called the song "an absolute motherfucker of a single" and opined it sounds "like a K-pop band covering nu-metal". Justin Kamp of Paste described the track as a "glitchy empowerment anthem that chugs along on screeching synths and Grimes' repeated exultations of power." == Personnel == Credits adapted from Tidal. Grimes – vocals, guitar, production, engineering Hana – vocals, guitar, additional production Chris Greatti – guitar, keyboards, production, engineering Zakk Cervini – mixing == Track listing == == Charts ==

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