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Imaging phantom
An imaging phantom, or simply phantom (less commonly spelled fantom), is a specially designed object that is scanned or imaged in the field of medical imaging to evaluate, analyze, and tune the performance of various imaging devices. A phantom is more readily available and provides more consistent results than the use of a living subject or cadaver, while also avoiding direct risks to living subjects. Phantoms were originally employed in 2D x-ray–based imaging techniques such as radiography or fluoroscopy, but more recently phantoms with desired imaging characteristics have been developed for 3D techniques such as SPECT, MRI, CT, ultrasound, PET, and other imaging modalities. == Design == A phantom used to evaluate an imaging device should respond in a similar manner to how human tissues and organs would act in that specific imaging modality. For instance, phantoms made for 2D radiography may hold various quantities of x-ray contrast agents with similar x-ray absorbing properties (such as the attenuation coefficient) to normal tissue to tune the contrast of the imaging device or modulate the patient's exposure to radiation. In such a case, the radiography phantom would not necessarily need to have similar textures and mechanical properties since these are not relevant in x-ray imaging modalities. However, in the case of ultrasonography, a phantom with similar rheological and ultrasound scattering properties to real tissue would be essential, but x-ray absorbing properties would not be relevant. The term "phantom" describes an object that is designed to resemble human tissue and can be evaluated, analyzed or manipulated to study the performance of a medical device. Phantoms are created using a digital file that is rendered through magnetic resonance imaging (MRI) or computer-aided design (CAD). The digital files allow for quick modifications that are read by the 3D printer. The 3D printer will create the product in successive layers using polymeric materials. There are several types of phantoms including tissue-mimicking, radiological phantoms, dental phantoms, BOMABs (used to calibrate whole-body counters), and more.
Voice activity detection
Voice activity detection (VAD), also known as speech activity detection or speech detection, is the detection of the presence or absence of human speech, used in speech processing. The main uses of VAD are in speaker diarization, speech coding and speech recognition. It can facilitate speech processing, and can also be used to deactivate some processes during non-speech section of an audio session: it can avoid unnecessary coding/transmission of silence packets in Voice over Internet Protocol (VoIP) applications, saving on computation and on network bandwidth. VAD is an important enabling technology for a variety of speech-based applications. Therefore, various VAD algorithms have been developed that provide varying features and compromises between latency, sensitivity, accuracy and computational cost. Some VAD algorithms also provide further analysis, for example whether the speech is voiced, unvoiced or sustained. Voice activity detection is usually independent of language. It was first investigated for use on time-assignment speech interpolation (TASI) systems. == Algorithm overview == The typical design of a VAD algorithm is as follows: There may first be a noise reduction stage, e.g. via spectral subtraction. Then some features or quantities are calculated from a section of the input signal. A classification rule is applied to classify the section as speech or non-speech – often this classification rule finds when a value exceeds a certain threshold. There may be some feedback in this sequence, in which the VAD decision is used to improve the noise estimate in the noise reduction stage, or to adaptively vary the threshold(s). These feedback operations improve the VAD performance in non-stationary noise (i.e. when the noise varies a lot). A representative set of recently published VAD methods formulates the decision rule on a frame by frame basis using instantaneous measures of the divergence distance between speech and noise. The different measures which are used in VAD methods include spectral slope, correlation coefficients, log likelihood ratio, cepstral, weighted cepstral, and modified distance measures. Independently from the choice of VAD algorithm, a compromise must be made between having voice detected as noise, or noise detected as voice (between false positive and false negative). A VAD operating in a mobile phone must be able to detect speech in the presence of a range of very diverse types of acoustic background noise. In these difficult detection conditions it is often preferable that a VAD should fail-safe, indicating speech detected when the decision is in doubt, to lower the chance of losing speech segments. The biggest difficulty in the detection of speech in this environment is the very low signal-to-noise ratios (SNRs) that are encountered. It may be impossible to distinguish between speech and noise using simple level detection techniques when parts of the speech utterance are buried below the noise. == Applications == VAD is an integral part of different speech communication systems such as audio conferencing, echo cancellation, speech recognition, speech encoding, speaker recognition and hands-free telephony. In the field of multimedia applications, VAD allows simultaneous voice and data applications. Similarly, in Universal Mobile Telecommunications Systems (UMTS), it controls and reduces the average bit rate and enhances overall coding quality of speech. In cellular radio systems (for instance GSM and CDMA systems) based on Discontinuous Transmission (DTX) mode, VAD is essential for enhancing system capacity by reducing co-channel interference and power consumption in portable digital devices. In speech processing applications, voice activity detection plays an important role since non-speech frames are often discarded. For a wide range of applications such as digital mobile radio, Digital Simultaneous Voice and Data (DSVD) or speech storage, it is desirable to provide a discontinuous transmission of speech-coding parameters. Advantages can include lower average power consumption in mobile handsets, higher average bit rate for simultaneous services like data transmission, or a higher capacity on storage chips. However, the improvement depends mainly on the percentage of pauses during speech and the reliability of the VAD used to detect these intervals. On the one hand, it is advantageous to have a low percentage of speech activity. On the other hand, clipping, that is the loss of milliseconds of active speech, should be minimized to preserve quality. This is the crucial problem for a VAD algorithm under heavy noise conditions. === Use in telemarketing === One controversial application of VAD is in conjunction with predictive dialers used by telemarketing firms. In order to maximize agent productivity, telemarketing firms set up predictive dialers to call more numbers than they have agents available, knowing most calls will end up in either "Ring – No Answer" or answering machines. When a person answers, they typically speak briefly ("Hello", "Good evening", etc.) and then there is a brief period of silence. Answering machine messages are usually 3–15 seconds of continuous speech. By setting VAD parameters correctly, dialers can determine whether a person or a machine answered the call and, if it's a person, transfer the call to an available agent. If it detects an answering machine message, the dialer hangs up. Often, even when the system correctly detects a person answering the call, no agent may be available, resulting in a "silent call". Call screening with a multi-second message like "please say who you are, and I may pick up the phone" will frustrate such automated calls. == Performance evaluation == To evaluate a VAD, its output using test recordings is compared with those of an "ideal" VAD – created by hand-annotating the presence or absence of voice in the recordings. The performance of a VAD is commonly evaluated on the basis of the following four parameters: FEC (Front End Clipping): clipping introduced in passing from noise to speech activity; MSC (Mid Speech Clipping): clipping due to speech misclassified as noise; OVER: noise interpreted as speech due to the VAD flag remaining active in passing from speech activity to noise; NDS (Noise Detected as Speech): noise interpreted as speech within a silence period. Although the method described above provides useful objective information concerning the performance of a VAD, it is only an approximate measure of the subjective effect. For example, the effects of speech signal clipping can at times be hidden by the presence of background noise, depending on the model chosen for the comfort noise synthesis, so some of the clipping measured with objective tests is in reality not audible. It is therefore important to carry out subjective tests on VADs, the main aim of which is to ensure that the clipping perceived is acceptable. In VoIP applications, front-end clipping can be reduced by rewinding to shortly before the detection and sending very slightly delayed data. This kind of test requires a certain number of listeners to judge recordings containing the processing results of the VADs being tested, giving marks to several speech sequences on the following features: Quality; Comprehension difficulty; Audibility of clipping. These marks are then used to calculate average results for each of the features listed above, thus providing a global estimate of the behavior of the VAD being tested. To conclude, whereas objective methods are very useful in an initial stage to evaluate the quality of a VAD, subjective methods are more significant. As they require the participation of several people for a few days, increasing cost, they are generally only used when a proposal is about to be standardized. == Implementations == One early standard VAD is that developed by British Telecom for use in the Pan-European digital cellular mobile telephone service in 1991. It uses inverse filtering trained on non-speech segments to filter out background noise, so that it can then more reliably use a simple power-threshold to decide if a voice is present. The G.729 standard calculates the following features for its VAD: line spectral frequencies, full-band energy, low-band energy (<1 kHz), and zero-crossing rate. It applies a simple classification using a fixed decision boundary in the space defined by these features, and then applies smoothing and adaptive correction to improve the estimate. The GSM standard includes two VAD options developed by ETSI. Option 1 computes the SNR in nine bands and applies a threshold to these values. Option 2 calculates different parameters: channel power, voice metrics, and noise power. It then thresholds the voice metrics using a threshold that varies according to the estimated SNR. The Speex audio compression library uses a procedure named Improved Minima Controlled Recursive Averaging, which uses a smoothed representation of spectral pow
G'MIC
G'MIC (GREYC's Magic for Image Computing) is a free and open-source framework for image processing. It defines a script language that allows the creation of complex macros. Originally usable only through a command line interface, it is currently mostly popular as a GIMP plugin, and is also included in Krita. G'MIC is dual-licensed under CECILL-2.1 or CECILL-C. == Features == G'MIC's graphical interface is notable for its noise removal filters, which came from an earlier project called GREYCstoration by the same authors. G'MIC offers many built-in commands for image processing, including basic mathematical manipulations, look up tables, and filtering operations. More complex macros and pipelines built out of those commands are defined in its library files. == Interpreters == === Command line === G'MIC is primarily a script language callable from a shell. For example, to display an image: This command displays the image contained in the file image.jpg and allows zooming in to examine values. Several filters can be applied in succession. For example, to crop and resize an image: === Graphical interface === G'MIC comes with a Qt-based graphical interface, which may be integrated as a Gimp or Krita plugin. It contains several hundred filters written in the G'MIC language, dynamically updated through an internet feed. The interface provides a preview and setting sliders for each filter. G'MIC is one of the most popular Gimp plugins. === G'MIC Online === Most of the filters available for the graphical interface are also available online. === ZArt === ZArt is a graphical interface for real-time manipulation of webcam images. === libgmic === Libgmic is a C++ library that can be linked to third-party applications. It sees integration in Flowblade and Veejay.
Imaging phantom
An imaging phantom, or simply phantom (less commonly spelled fantom), is a specially designed object that is scanned or imaged in the field of medical imaging to evaluate, analyze, and tune the performance of various imaging devices. A phantom is more readily available and provides more consistent results than the use of a living subject or cadaver, while also avoiding direct risks to living subjects. Phantoms were originally employed in 2D x-ray–based imaging techniques such as radiography or fluoroscopy, but more recently phantoms with desired imaging characteristics have been developed for 3D techniques such as SPECT, MRI, CT, ultrasound, PET, and other imaging modalities. == Design == A phantom used to evaluate an imaging device should respond in a similar manner to how human tissues and organs would act in that specific imaging modality. For instance, phantoms made for 2D radiography may hold various quantities of x-ray contrast agents with similar x-ray absorbing properties (such as the attenuation coefficient) to normal tissue to tune the contrast of the imaging device or modulate the patient's exposure to radiation. In such a case, the radiography phantom would not necessarily need to have similar textures and mechanical properties since these are not relevant in x-ray imaging modalities. However, in the case of ultrasonography, a phantom with similar rheological and ultrasound scattering properties to real tissue would be essential, but x-ray absorbing properties would not be relevant. The term "phantom" describes an object that is designed to resemble human tissue and can be evaluated, analyzed or manipulated to study the performance of a medical device. Phantoms are created using a digital file that is rendered through magnetic resonance imaging (MRI) or computer-aided design (CAD). The digital files allow for quick modifications that are read by the 3D printer. The 3D printer will create the product in successive layers using polymeric materials. There are several types of phantoms including tissue-mimicking, radiological phantoms, dental phantoms, BOMABs (used to calibrate whole-body counters), and more.
ELIZA
ELIZA is an early natural language processing computer program developed from 1964 to 1967 at MIT by Joseph Weizenbaum. Created to explore communication between humans and machines, ELIZA simulated conversation by using a pattern matching and substitution methodology that gave users an illusion of understanding on the part of the program, but gave no response that could be considered really understanding what was being said by either party. Whereas the ELIZA program itself was written (originally) in MAD-SLIP, the pattern matching directives that contained most of its language capability were provided in separate "scripts", represented in a Lisp-like expression. The most famous script, DOCTOR, simulated a psychotherapist of the Rogerian school (in which the therapist often reflects back the patient's words to the patient), and used rules, dictated in the script, to respond with non-directional questions to user inputs. As such, ELIZA was one of the first chatbots (originally "chatterbots") and one of the first programs capable of attempting the Turing test. Weizenbaum intended the program as a method to explore communication between humans and machines. He was surprised that some people, including his secretary, attributed human-like feelings to the computer program, a phenomenon that came to be called the ELIZA effect. Many academics believed that the program would be able to positively influence the lives of many people, particularly those with psychological issues, and that it could aid doctors working on such patients' treatment. While ELIZA was capable of engaging in discourse, it could not converse with true understanding. However, many early users were convinced of ELIZA's intelligence and understanding, despite Weizenbaum's insistence to the contrary. The original ELIZA source code had been missing since its creation in the 1960s, as it was not common to publish articles that included source code at that time. However, more recently the MAD-SLIP source code was discovered in the MIT archives and published on various platforms, such as the Internet Archive. The source code is of high historical interest since it demonstrates not only the specificity of programming languages and techniques at that time, but also the beginning of software layering and abstraction as a means of achieving sophisticated software programming. == Overview == Joseph Weizenbaum's ELIZA, running the DOCTOR script, created a conversational interaction somewhat similar to what might take place in the office of "a [non-directive] psychotherapist in an initial psychiatric interview" and to "demonstrate that the communication between man and machine was superficial". While ELIZA is best known for acting in the manner of a psychotherapist, the speech patterns are due to the data and instructions supplied by the DOCTOR script. ELIZA itself examined the text for keywords, applied values to said keywords, and transformed the input into an output; the script that ELIZA ran determined the keywords, set the values of keywords, and set the rules of transformation for the output. Weizenbaum chose to make the DOCTOR script in the context of psychotherapy to "sidestep the problem of giving the program a data base of real-world knowledge", allowing it to reflect back the patient's statements to carry the conversation forward. The result was a somewhat intelligent-seeming response that reportedly deceived some early users of the program. Weizenbaum named his program ELIZA after Eliza Doolittle, a working-class character in George Bernard Shaw's Pygmalion (also appearing in the musical My Fair Lady, which was based on the play and was hugely popular at the time). According to Weizenbaum, ELIZA's ability to be "incrementally improved" by various users made it similar to Eliza Doolittle, since Eliza Doolittle was taught to speak with an upper-class accent in Shaw's play. However, unlike the human character in Shaw's play, ELIZA is incapable of learning new patterns of speech or new words through interaction alone. Edits must be made directly to ELIZA's active script in order to change the manner by which the program operates. Weizenbaum first implemented ELIZA in his own SLIP list-processing language, where, depending upon the initial entries by the user, the illusion of human intelligence could appear, or be dispelled through several interchanges. Some of ELIZA's responses were so convincing that Weizenbaum and several others have anecdotes of users becoming emotionally attached to the program, occasionally forgetting that they were conversing with a computer. Weizenbaum's own secretary reportedly asked Weizenbaum to leave the room so that she and ELIZA could have a real conversation. Weizenbaum was surprised by this, later writing: "I had not realized ... that extremely short exposures to a relatively simple computer program could induce powerful delusional thinking in quite normal people." In 1966, interactive computing (via a teletype) was new. It was 11 years before the personal computer became familiar to the general public, and three decades before most people encountered attempts at natural language processing in Internet services like Ask.com or PC help systems such as Microsoft Office Clippit. Although those programs included years of research and work, ELIZA remains a milestone because it was the first time a programmer had attempted such a human-machine interaction with the goal of creating the illusion (however brief) of human–human interaction. At the ICCC 1972, ELIZA was brought together with another early artificial-intelligence program named PARRY for a computer-only conversation. While ELIZA was built to speak as a doctor, PARRY was intended to simulate a patient with schizophrenia. == Design and implementation == Weizenbaum originally wrote ELIZA in MAD-SLIP for CTSS on an IBM 7094 as a program to make natural-language conversation possible with a computer. To accomplish this, Weizenbaum identified five "fundamental technical problems" for ELIZA to overcome: the identification of key words, the discovery of a minimal context, the choice of appropriate transformations, the generation of responses in the absence of key words, and the provision of an editing capability for ELIZA scripts. Weizenbaum solved these problems and made ELIZA such that it had no built-in contextual framework or universe of discourse. However, this required ELIZA to have a script of instructions on how to respond to inputs from users. ELIZA starts its process of responding to an input by a user by first examining the text input for a "keyword". A "keyword" is a word designated as important by the acting ELIZA script, which assigns to each keyword a precedence number, or a RANK, designed by the programmer. If such words are found, they are put into a "keystack", with the keyword of the highest RANK at the top. The input sentence is then manipulated and transformed as the rule associated with the keyword of the highest RANK directs. For example, when the DOCTOR script encounters words such as "alike" or "same", it would output a message pertaining to similarity, in this case "In what way?", as these words had high precedence number. This also demonstrates how certain words, as dictated by the script, can be manipulated regardless of contextual considerations, such as switching first-person pronouns and second-person pronouns and vice versa, as these too had high precedence numbers. Such words with high precedence numbers are deemed superior to conversational patterns and are treated independently of contextual patterns. Following the first examination, the next step of the process is to apply an appropriate transformation rule, which includes two parts: the "decomposition rule" and the "reassembly rule". First, the input is reviewed for syntactical patterns in order to establish the minimal context necessary to respond. Using the keywords and other nearby words from the input, different disassembly rules are tested until an appropriate pattern is found. Using the script's rules, the sentence is then "dismantled" and arranged into sections of the component parts as the "decomposition rule for the highest-ranking keyword" dictates. The example that Weizenbaum gives is the input "You are very helpful", which is transformed to "I are very helpful". This is then broken into (1) empty (2) "I" (3) "are" (4) "very helpful". The decomposition rule has broken the phrase into four small segments that contain both the keywords and the information in the sentence. The decomposition rule then designates a particular reassembly rule, or set of reassembly rules, to follow when reconstructing the sentence. The reassembly rule takes the fragments of the input that the decomposition rule had created, rearranges them, and adds in programmed words to create a response. Using Weizenbaum's example previously stated, such a reassembly rule would take the fragments and apply them to the phrase "What makes
Reverse correlation technique
The reverse correlation technique is a data driven study method used primarily in psychological and neurophysiological research. This method earned its name from its origins in neurophysiology, where cross-correlations between white noise stimuli and sparsely occurring neuronal spikes could be computed quicker when only computing it for segments preceding the spikes. The term has since been adopted in psychological experiments that usually do not analyze the temporal dimension, but also present noise to human participants. In contrast to the original meaning, the term is here thought to reflect that the standard psychological practice of presenting stimuli of defined categories to the participants is "reversed": Instead, the participant's mental representations of categories are estimated from interactions of the presented noise and the behavioral responses. It is used to create composite pictures of individual and/or group mental representations of various items (e.g. faces, bodies, and the self) that depict characteristics of said items (e.g. trustworthiness and self-body image). This technique is helpful when evaluating the mental representations of those with and without mental illnesses. == Terms == This technique utilizes spike-triggered average to explain what areas of signal and noise in an image are valuable for the given research question. Signal is information used to produce objects of value that help explain and connect the world around us. Noise is commonly referred to as unwanted signal that obscures the information that the signal is trying to present. Most importantly for reverse correlation studies, noise is randomly varying information. To determine the areas of importance using reverse correlation, noise is applied to a base image and then evaluated by observers. A base image is any image void of noise that relates to the research question. A base image that has noise superimposed on top is the stimuli that is presented to and evaluated by participants. Each time a new set of stimuli is presented to a participant, this is known as a trial. After a participant has responded to hundreds to thousands of trials, a researcher is ready to create a classification image. A classification image (abbreviated as "CI" in some studies) is a single image that represents the average noise patterns in the images selected by participants. A classification image can also be computed for groups by averaging the individuals’ classification images. These classification images are what researchers use to interpret the data and draw conclusions. As a whole, the reverse correlation method is a process that results in a composite image (from an individual or group) that can be used to estimate and interpret mental representations. == Basic study layout == The reverse correlation method is typically executed as an in-lab computer experiment. This method follows four broad steps. Each of the following steps are described in greater detail below. After creating a research question and determining that the reverse correlation method is the most suitable technique to answer the question, a researcher must (1) design randomly varying stimuli. After the stimuli have been prepared, a researcher should (2) collect data from participants who will see and respond to approximately 300 -1,000 trials. Each trial will either consist of one or two images (side by side) derived from the same base image with noise superimposed on top. Participant responses will depend on the chosen study design; if a researcher presents only one image at a time, participants rate the image on a 4pt scale, but when two images are shown, the participant is asked to choose which best aligns with the given category (e.g. choose the image that looks the most aggressive). Once all of the data is collected, the researcher will (3) compute classification images for each participant and using those images compute group classification images. Finally, with the classification images available, the researcher will (4) evaluate the images and draw conclusions about their results. === Step 1: making stimuli === When designing the stimuli for a reverse correlation study, the two primary factors that one should consider are (1) the base image and (2) the noise that will be used. While not all bases are images per se, the majority are and for this reason the base is typically referred to as a base image. The base image should represent whatever the research question is addressing. For example, if you are interested in peoples’ mental representations of Chinese people, it would not make sense to use a base image of a Spanish or Caucasian person. Again, if you are interested in the mental representations of male vocal patterns, it would make the most sense to use a base vocal pattern that has been produced by a male. Having a base is important because it provides a kind of anchor for participants to work from. When there is no base image, the number of trials that are required increases dramatically, thus making it harder to collect data. While there are studies that have excluded a base image, (e.g. the S study), for more elaborate and nuanced research questions, it is important to have a base image that is a fair representation of what participants are being asked to categorize. Photographs of faces are generally the most popular base image. Although the reverse correlation method is capable of investigating a wide variety of research questions, the most common application of the method is for evaluating faces on a single trait. Reverse correlation studies that address evaluations of the face are sometimes referred to as being a face space reverse correlation model (FSRCM). Thankfully, there are existing databases for face images of varying demographics and emotion that work well as base images. The reverse correlation method can also be used to help researchers identify what areas of an image (e.g. the areas on the face) have diagnostic value. In order to identify these areas of value, researchers start by minimizing the space a participant can pull information from. By imposing a “mask” on an image (e.g. blur an image while leaving random areas un-blurred), this reduces the information individuals might see, and forces them to focus on certain areas. Then, if/when participants are able to correctly identify an image with a trait repeatedly, we can draw conclusions about what areas have diagnostic value. While faces and visual stimuli are the most popular, this is not the only stimuli that can be used in a reverse correlation study. This method was originally designed for auditory stimuli which allows researchers to investigate how perceivers interpret auditory information and create trait based attributions to different sound patterns. For example, by segmenting a vocal recording of a single word (total sound time 426 ms) into six segments (71 ms each), and varying each segment's pitch using Gaussian distributions, researchers were able to uncover what vocal patterns people associated with certain traits. Specifically, this study investigated how listeners rated sound clips of the word “really” as sounding more interrogative (i.e. like the more common reverse correlation studies this study had participants listen to two sound clips per trial, choose which fit the category the best, and then created an average of the pitch contours). Beyond face and auditory perception, research utilizing the reverse correlation method has expanded to investigate how individuals see three-dimensional objects in images with noise (but no signal). After selecting your base image, regardless of what the image is, it is helpful to apply a Gaussian blur to smooth noise in the image. While noise will be applied later, it is helpful to reduce existing noise in the photo before applying your chosen noise. There are three primary choices when it comes to noise: white noise, sine-wave noise, and Gabor noise. The latter two of these constrain the configurations that the noise can have, and because of this white noise is usually the most commonly used. Regardless of the type of noise that is chosen, it is crucial that the noise randomly varies. === Step 2: data collection === Once the stimuli for the study has been developed, the researcher must make a few decisions before actually collecting the data. The researcher must come to a conclusion on how many stimuli will be presented at a time and how many trials the participants will see. In terms of stimuli presentation, a researcher can choose from either a 2-Image Forced Choice (2IFC) or a 4-Alternative Forced Choice (4AFC). The 2IFC presents two images at once (side by side) and requires participants to choose between the two on a specified category (e.g. which image looks the most like a male). Typically the noise from the left image is the mathematical inverse of the noise from the right image. This method was developed to better answer questions that could n