Lynda Soderholm is a physical chemist at the U.S. Department of Energy's (DOE) Argonne National Laboratory with a specialty in f-block elements. She is a senior scientist and the lead of the Actinide, Geochemistry & Separation Sciences Theme within Argonne's Chemical Sciences and Engineering Division. Her specific role is the Separation Science group leader within Heavy Element Chemistry and Separation Science (HESS), directing basic research focused on low-energy methods for isolating lanthanide and actinide elements from complex mixtures. She has made fundamental contributions to understanding f-block chemistry and characterizing f-block elements. Soderholm became a Fellow of the American Association for the Advancement of Science (AAAS) in 2013, and is also an Argonne Distinguished Fellow. == Early life and education == Soderholm was awarded her PhD in 1982 by McMaster University under the direction of Prof John Greedan. Her dissertation focused on characterizing the structural and magnetic properties of a series of ternary f-ion oxides. After graduating, she was awarded a NATO postdoctoral fellow at the Centre national de la recherche scientifique in France from 1982 until 1985. After a short postdoctoral appointment as an Argonne postdoctoral fellow she was promoted to staff scientist the same year. Over several years, she moved up the ranks, becoming a senior chemist in 2001. She was also an adjunct professor at the University of Notre Dame from 2003 until 2007. In 2021, Soderholm was appointed interim Division Director for the Chemical Sciences and Engineering Division. == Career and research == === Uncovering structure of Yttrium-123 Superconductor === Early in her career, Soderholm focused on the characterizing the magnetic and electronic behavior of compounds containing f-ions (lanthanides and actinides) with a focus on high-Tc materials, compounds that are superconducting under usually high temperatures. She was part of the research group that first determined the structure of YBa2Cu3O7. Their discovery formed the foundation for the further developments in the broad field of superconductivity. === Understanding f-ion speciation in solution === Continuing her interest in the f-elements, Soderholm shifted her focus from solid-state materials to nanoparticles and solutions, taking advantage of advances in X-ray structural probes made available by synchrotron facilities. Building on her earlier work using neutron scattering, her team became the first to discover that plutonium exists in solution as tiny, well-defined nanoparticles. This work solved a longstanding problem in understanding transport of plutonium in the environment and resulted in the development of a new, patented approach to separating plutonium during nuclear reprocessing. === Using machine learning to evaluate molecular structures === Soderholm's more recent projects use machine learning to understand the influence of complex molecular structuring in solutions, in connection with low-energy processes for separation of f-block elements from complex mixtures. == Awards and honors == University of Chicago Board of Governors' Distinguished Performance Award, 2009. Fellow of the American Association for the Advancement of Science, 2013. Argonne Distinguished Fellow, 2016 DOE materials sciences research competition for Outstanding Scientific Accomplishments in Solid State Physics, 1987. == Select publications == Beno, M. A.; Soderholm, L.; Capone, D. W., II; Hinks, D. G.; Jorgensen, J. D.; Grace, J. D.; Schuller, I. K.; Segre, C. U.; Zhang, K., Structure of the single-phase high-temperature superconductor yttrium barium copper oxide (YBa2Cu3O7−δ). Appl. Phys. Lett. 1987, 51 (1), 57–9. Soderholm, L.; Zhang, K.; Hinks, D. G.; Beno, M. A.; Jorgensen, J. D.; Segre, C. U.; Schuller, I. K., Incorporation of praseodymium in YBa2Cu3O7−δ: electronic effects on superconductivity. Nature (London) 1987, 328 (6131), 604–5. Antonio, M. R.; Williams, C. W.; Soderholm, L., Berkelium redox speciation. Radiochim. Acta 2002, 90 (12), 851–856. Soderholm, L.; Skanthakumar, S.; Neuefeind, J., Determination of actinide speciation in solution using high-energy X-ray scattering. Anal. Bioanal. Chem. 2005, 383 (1), 48–55. Forbes, T. Z.; Burns, P. C.; Skanthakumar, S.; Soderholm, L., Synthesis, structure, and magnetism of Np2O5. J. Am. Chem. Soc. 2007, 129 (10), 2760–2761. Soderholm, L.; Almond, P. M.; Skanthakumar, S.; Wilson, R. E.; Burns, P. C., The structure of the plutonium oxide nanocluster [Pu38O56Cl54(H2O)8]14-. Angew. Chem., Int. Ed. 2008, 47 (2), 298–302. Jensen, M. P.; Gorman-Lewis, D.; Aryal, B.; Paunesku, T.; Vogt, S.; Rickert, P. G.; Seifert, S.; Lai, B.; Woloschak, G. E.; Soderholm, L., An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium. Nat. Chem. Biol. 2011, 7 (8), 560–565. Wilson, R. E.; Skanthakumar, S.; Soderholm, L., Separation of Plutonium Oxide Nanoparticles and Colloids. Angew. Chem., Int. Ed. 2011, 50 (47), 11234–11237. Knope, K. E.; Soderholm, L., Solution and solid-state structural chemistry of actinide hydrates and their hydrolysis and condensation products. Chem. Rev. 2013, 113 (2), 944–994. Luo, G.; Bu, W.; Mihaylov, M.; Kuzmenko, I.; Schlossman, M. L.; Soderholm, L., X-ray reflectivity reveals a nonmonotonic ion-density profile perpendicular to the surface of ErCl3 aqueous solutions. J. Phys. Chem. C 2013, 117 (37), 19082–19090. Jin, G. B.; Lin, J.; Estes, S. L.; Skanthakumar, S.; Soderholm, L., Influence of countercation hydration enthalpies on the formation of molecular complexes: A thorium-nitrate example. J. Am. Chem. Soc. 2017, 139 (49), 18003–18008. == Patents == Solvent extraction system for plutonium colloids and other oxide nano-particles, (2016).
AIX Toolbox for Linux Applications
The AIX Toolbox for Linux Applications is a collection of GNU tools for IBM AIX. These tools are available for installation using Red Hat's RPM format. == Licensing == Each of these packages includes its own licensing information and while IBM has made the code available to AIX users, the code is provided as is and has not been thoroughly tested. The Toolbox is meant to provide a core set of some of the most common development tools and libraries along with the more popular GNU packages.
GitHub Codespaces
GitHub Codespaces is a cloud-based online integrated development environment developed by GitHub. It allows users to create and manage development environments directly within the browser or through Visual Studio Code desktop. Codespaces is tightly integrated with GitHub repositories and enables on-demand coding, debugging, and testing in a full-featured development container hosted in the cloud. == Features == Instant development environments integrated with GitHub Browser-based and desktop access via Visual Studio Code Configurable Dockerfile or devcontainer.json environments Built-in support for GitHub Copilot, extensions, snippets, and SSH. == Licensing == GitHub Codespaces is proprietary software and available to GitHub users under various subscription plans. Codespaces includes a monthly usage quota for free tier users of 120 hours, and expanded access for GitHub education, Pro, Team, and GitHub Enterprise plans. == GitHub Classroom == GitHub Classroom is an educational tool developed by GitHub to streamline the process of managing programming assignments and coursework. Integrated with GitHub repositories, it allows instructors to distribute starter code, automate grading workflows, and track student progress. GitHub Classroom is widely used in computer science education and supports integration with GitHub Codespaces for cloud-based development environments. == Programming languages supported == == Extensions == Some of the popular extensions include:
Chirplet transform
In signal processing, the chirplet transform is an inner product of an input signal with a family of analysis primitives called chirplets. Similar to the wavelet transform, chirplets are usually generated from (or can be expressed as being from) a single mother chirplet (analogous to the so-called mother wavelet of wavelet theory). == Definitions == The term chirplet transform was coined by Steve Mann, as the title of the first published paper on chirplets. The term chirplet itself (apart from chirplet transform) was also used by Steve Mann, Domingo Mihovilovic, and Ronald Bracewell to describe a windowed portion of a chirp function. In Mann's words: A wavelet is a piece of a wave, and a chirplet, similarly, is a piece of a chirp. More precisely, a chirplet is a windowed portion of a chirp function, where the window provides some time localization property. In terms of time–frequency space, chirplets exist as rotated, sheared, or other structures that move from the traditional parallelism with the time and frequency axes that are typical for waves (Fourier and short-time Fourier transforms) or wavelets. The chirplet transform thus represents a rotated, sheared, or otherwise transformed tiling of the time–frequency plane. Although chirp signals have been known for many years in radar, pulse compression, and the like, the first published reference to the chirplet transform described specific signal representations based on families of functions related to one another by time–varying frequency modulation or frequency varying time modulation, in addition to time and frequency shifting, and scale changes. In that paper, the Gaussian chirplet transform was presented as one such example, together with a successful application to ice fragment detection in radar (improving target detection results over previous approaches). The term chirplet (but not the term chirplet transform) was also proposed for a similar transform, apparently independently, by Mihovilovic and Bracewell later that same year. == Applications == The first practical application of the chirplet transform was in water-human-computer interaction (WaterHCI) for marine safety, to assist vessels in navigating through ice-infested waters, using marine radar to detect growlers (small iceberg fragments too small to be visible on conventional radar, yet large enough to damage a vessel). Other applications of the chirplet transform in WaterHCI include the SWIM (Sequential Wave Imprinting Machine). More recently other practical applications have been developed, including image processing (e.g. where there is periodic structure imaged through projective geometry), as well as to excise chirp-like interference in spread spectrum communications, in EEG processing, and Chirplet Time Domain Reflectometry. == Extensions == The warblet transform is a particular example of the chirplet transform introduced by Mann and Haykin in 1992 and now widely used. It provides a signal representation based on cyclically varying frequency modulated signals (warbling signals).
Online OS
The Online Operating System was a fully multi-lingual and free to use web desktop written in JavaScript using Ajax. It was a Windows-based desktop environment with open-source applications and system utilities developed upon the reBOX web application framework by iCUBE Network Solutions, an Austrian company located in Vienna. == About the project == OOS.cc, which is short for Online Operating System, was a web application platform that mimicked the look and feel of classic desktop operating systems such as Microsoft Windows, Mac OS X or KDE. It consisted of various open source applications built upon the so-called reBOX web application framework. As applications could be executed in an integrated and parallel way, the OOS could have been considered a web desktop or webtop. It provided basic services such as a GUI, a virtual file system, access control management and possibilities to develop and deploy applications online. As the Online Operating System was executed within a web browser, it was no real operating system but rather a portal to various web applications, offering a high usability and flexibility. The project was partly funded by grants from the Internetprivatstiftung Austria (IPA). As at 01.08.2008 almost 20.000 users have joined the oos.cc community, using the offered featured and applications. == History == The development of the web desktop was started by iCUBE Network Solutions in 2005, followed by the first beta releases in 2006. Hence, together with YouOS and eyeOS, it can be considered to be one of the first publicly available systems of its kind. The first full version including core-level multi-language support, the file system and a basic set of applications was released to the public in March 2007 on the occasion of a national exhibition (ITnT Austria Archived 2007-06-30 at the Wayback Machine) and has left beta state half a year later in October 2007. The first release considered stable (1.0.0) was published in July 2007. The project itself and the contained applications have received several national innovation awards (see,) and have gained attention mainly due to the comprehensive approach taken (see,). OOS.cc started as a national project. The full platform including all offered applications are currently available in three languages (German, English as well as Spanish) and is receiving increasing coverage around the world (for examples see, or). The current version is 1.3.01 from 01.08.2008. == Technical overview == The project is fully written in JavaScript, exclusively using DHTML techniques to run in any web browser without any additional software installation needed. The system implements a modern kind of web application model, excessively using Ajax for communicating between client components and the Java server backend in an exclusively asynchronous manner. Aim is to offer users the unique interaction behavior following the desktop metaphor, which is the main idea of any web desktop. Also typical for this sort of web application is the broadly use of Javascript-on-demand techniques, cutting the complete project source into pieces and loading them instantly when needed. Based on this technical basis, reBOX was the framework library all applications in oos.cc were built of. It is a fully flexible and extensible API, including a GUI widget set, communication mechanisms and server services offering general and framework specific services. The Online Operating System itself consisted of a basic framework, which was able to launch any JavaScript application using the reBOX library. The user interface was based on the behavior of the Windows desktop with a start menu, a task bar and a desktop background. All applications were running in this environment. At server side, there were Java based web services that ran to serve the client processes and to provide data from the relational database in the backend. oos.cc also provided an integrated development environment called Developer Suite, which allowed the community to build own applications for the desktop environment based on reBOX (see development section below). == License == All applications available in oos.cc were open source under the European Union Public Licence (EUPL). The reBOX development toolkit is free to use developing any applications for the webtop. == Features == As mentioned above, all applications published on oos.cc are open source based on the EUPL, and can be "installed" or "deinstalled" to what-ever preferences the user has. Besides global services like the multi-language support or the global theme support, as well as some minor tools and games, oos.cc offered four major services that could be used completely free of charge. Integrated and fully flexible file storage (1 GB per user) HTTP as well as FTP file transfer from and to local file system User-based file-shares within the oos-community WebDAV access Document Management (including Version Control and File Locking mechanisms) Image publishing, organization and post-processing A free sub domain (user.oos.cc) for web- or image publishing, directly integrated in the desktop Groupware applications, including free mail, fetchmail and contact management An integrated development environment where oos-applications can be created directly from within the system (see development section below) Next releases were planned to focus on an extensive security and privacy suite, dealing with challenges like anonymous communication (browsing as well as temporary mail-addresses) as well as offering encrypted password and file storage and connectivity services. Since its initial stable release, OOS.cc could have been accessed using https to ensure secure communication. == Limitations and drawbacks == Limited number of applications: no commercial applications can be hosted. Only reviewed applications are being published No processing of popular office formats (.doc, .odt, etc.) Limited language support: Only English, German and Spanish Dependence on foreign infrastructure: No possibility to extend storage, no additional/guaranteed bandwidth, etc. == Development == One of the key focuses of the team was right from the beginning to offer a very flexible and comprehensive API, that can be used to develop not only custom applications within oos.cc, but also stand-alone web-applications or to integrate single components in existing web-sites. By decoupling the development from web-related "problems" using the reBOX API web-applications can be development in a similar fashion to any Java program: Elements can be positioned and can interact like in high-level object oriented programming languages, without taking care of divs, browser specific behavior or communication handling. The framework also offers multi-language and theme support for existing as well as newly created applications, allowing changing almost every aspect of the look and feel of the used components according to the preferences of its users. For taking advantage of this approach, one of the applications offered in the OOS was an integrated Development Suite, allowing directly writing and executing code and hence creating new programs within the boundaries of the web computer. All applications on oos.cc were released as open source, thus all existing programs were offered to be imported, reviewed or changed and then locally deployed. Following this idea, every user was free to submit changed or newly created applications to be included in the globally offered application set. The last release offered features like auto-completion and an outline-window.
Speech recognition
Speech recognition (automatic speech recognition (ASR), computer speech recognition, or speech-to-text (STT)) is a sub-field of computational linguistics concerned with methods and technologies that translate spoken language into text or other interpretable forms. Speech recognition applications include voice user interfaces, where the user speaks to a device, which "listens" and processes the audio. Common voice applications include interpreting commands for calling, call routing, home automation, and aircraft control. These applications are called direct voice input. Productivity applications include searching audio recordings, creating transcripts, and dictation. Speech recognition can be used to analyse speaker characteristics, such as identifying native language using pronunciation assessment. Voice recognition (speaker identification) refers to identifying the speaker, rather than speech contents. Recognizing the speaker can simplify the task of translating speech in systems trained on a specific person's voice. It can also be used to authenticate the speaker as part of a security process. == History == Applications for speech recognition developed over many decades, with progress accelerated due to advances in deep learning and the use of big data. These advances are reflected in an increase in academic papers, and greater system adoption. Key areas of growth include vocabulary size, more accurate recognition for unfamiliar speakers (speaker independence), and faster processing speed. === Pre-1970 === 1952 – Bell Labs researchers, Stephen Balashek, R. Biddulph, and K. H. Davis, built Audrey for single-speaker digit recognition. Their system located the formants in the power spectrum of each utterance. 1960 – Gunnar Fant developed and published the source–filter model of speech production. 1962 – IBM's 16-word "Shoebox" machine's speech recognition debuted at the 1962 World's Fair. 1966 – Linear predictive coding, a speech coding method, was proposed by Fumitada Itakura of Nagoya University and Shuzo Saito of Nippon Telegraph and Telephone. 1969 – Funding at Bell Labs came to a halt for several years after the company's head engineer, John R. Pierce, wrote an open letter criticizing speech recognition research. This defunding lasted until Pierce retired and James L. Flanagan took over. Raj Reddy was the first person to work on continuous speech recognition, as a graduate student at Stanford University in the late 1960s. Previous systems required users to pause after each word. Reddy's system issued spoken commands for playing chess. Around this time, Soviet researchers invented the dynamic time warping (DTW) algorithm and used it to create a recognizer capable of operating on a 200-word vocabulary. DTW processed speech by dividing it into short frames (e.g. 10 ms segments) and treating each frame as a unit. Speaker independence, however, remained unsolved. === 1970–1990 === 1971 – DARPA funded a five-year speech recognition research project, Speech Understanding Research, seeking a minimum vocabulary size of 1,000 words. The project considered speech understanding a key to achieving progress in speech recognition, which was later disproved. BBN, IBM, Carnegie Mellon (CMU), and Stanford Research Institute participated. 1972 – The IEEE Acoustics, Speech, and Signal Processing group held a conference in Newton, Massachusetts. 1976 – The first ICASSP was held in Philadelphia, which became a major venue for publishing on speech recognition. During the late 1960s, Leonard Baum developed the mathematics of Markov chains at the Institute for Defense Analysis. A decade later, at CMU, Raj Reddy's students James Baker and Janet M. Baker began using the hidden Markov model (HMM) for speech recognition. James Baker had learned about HMMs while at the Institute for Defense Analysis. HMMs enabled researchers to combine sources of knowledge, such as acoustics, language, and syntax, in a unified probabilistic model. By the mid-1980s, Fred Jelinek's team at IBM created a voice-activated typewriter called Tangora, which could handle a 20,000-word vocabulary. Jelinek's statistical approach placed less emphasis on emulating human brain processes in favor of statistical modelling. (Jelinek's group independently discovered the application of HMMs to speech.) This was controversial among linguists since HMMs are too simplistic to account for many features of human languages. However, the HMM proved to be a highly useful way for modelling speech and replaced dynamic time warping as the dominant speech recognition algorithm in the 1980s. 1982 – Dragon Systems, founded by James and Janet M. Baker, was one of IBM's few competitors. === Practical speech recognition === The 1980s also saw the introduction of the n-gram language model. 1987 – The back-off model enabled language models to use multiple-length n-grams, and CSELT used HMM to recognize languages (in software and hardware, e.g. RIPAC). At the end of the DARPA program in 1976, the best computer available to researchers was the PDP-10 with 4 MB of RAM. It could take up to 100 minutes to decode 30 seconds of speech. Practical products included: 1984 – the Apricot Portable was released with up to 4096 words support, of which only 64 could be held in RAM at a time. 1987 – a recognizer from Kurzweil Applied Intelligence 1990 – Dragon Dictate, a consumer product released in 1990. AT&T deployed the Voice Recognition Call Processing service in 1992 to route telephone calls without a human operator. The technology was developed by Lawrence Rabiner and others at Bell Labs. By the early 1990s, the vocabulary of the typical commercial speech recognition system had exceeded the average human vocabulary. Reddy's former student, Xuedong Huang, developed the Sphinx-II system at CMU. Sphinx-II was the first to do speaker-independent, large vocabulary, continuous speech recognition, and it won DARPA's 1992 evaluation. Handling continuous speech with a large vocabulary was a major milestone. Huang later founded the speech recognition group at Microsoft in 1993. Reddy's student Kai-Fu Lee joined Apple, where, in 1992, he helped develop the Casper speech interface prototype. Lernout & Hauspie, a Belgium-based speech recognition company, acquired other companies, including Kurzweil Applied Intelligence in 1997 and Dragon Systems in 2000. L&H was used in Windows XP. L&H was an industry leader until an accounting scandal destroyed it in 2001. L&H speech technology was bought by ScanSoft, which became Nuance in 2005. Apple licensed Nuance software for its digital assistant Siri. ==== 2000s ==== In the 2000s, DARPA sponsored two speech recognition programs: Effective Affordable Reusable Speech-to-Text (EARS) in 2002, followed by Global Autonomous Language Exploitation (GALE) in 2005. Four teams participated in EARS: IBM; a team led by BBN with LIMSI and the University of Pittsburgh; Cambridge University; and a team composed of ICSI, SRI, and the University of Washington. EARS funded the collection of the Switchboard telephone speech corpus, which contained 260 hours of recorded conversations from over 500 speakers. The GALE program focused on Arabic and Mandarin broadcast news. Google's first effort at speech recognition came in 2007 after recruiting Nuance researchers. Its first product, GOOG-411, was a telephone-based directory service. Since at least 2006, the U.S. National Security Agency has employed keyword spotting, allowing analysts to index large volumes of recorded conversations and identify speech containing "interesting" keywords. Other government research programs focused on intelligence applications, such as DARPA's EARS program and IARPA's Babel program. In the early 2000s, speech recognition was dominated by hidden Markov models combined with feed-forward artificial neural networks (ANN). Later, speech recognition was taken over by long short-term memory (LSTM), a recurrent neural network (RNN) published by Sepp Hochreiter & Jürgen Schmidhuber in 1997. LSTM RNNs avoid the vanishing gradient problem and can learn "Very Deep Learning" tasks that require memories of events that happened thousands of discrete time steps earlier, which is important for speech. Around 2007, LSTMs trained with Connectionist Temporal Classification (CTC) began to outperform. In 2015, Google reported a 49 percent error‑rate reduction in its speech recognition via CTC‑trained LSTM. Transformers, a type of neural network based solely on attention, were adopted in computer vision and language modelling, and then to speech recognition. Deep feed-forward (non-recurrent) networks for acoustic modelling were introduced in 2009 by Geoffrey Hinton and his students at the University of Toronto, and by Li Deng and colleagues at Microsoft Research. In contrast to the prioer incremental improvements, deep learning decreased error rates by 30%. Both shallow and deep forms (e.g., recurrent nets) of ANNs had been explored since the 1980s. Howev
Discrete skeleton evolution
Discrete Skeleton Evolution (DSE) describes an iterative approach to reducing a morphological or topological skeleton. It is a form of pruning in that it removes noisy or redundant branches (spurs) generated by the skeletonization process, while preserving information-rich "trunk" segments. The value assigned to individual branches varies from algorithm to algorithm, with the general goal being to convey the features of interest of the original contour with a few carefully chosen lines. Usually, clarity for human vision (aka. the ability to "read" some features of the original shape from the skeleton) is valued as well. DSE algorithms are distinguished by complex, recursive decision-making processes with high computational requirements. Pruning methods such as by structuring element (SE) convolution and the Hough transform are general purpose algorithms which quickly pass through an image and eliminate all branches shorter than a given threshold. DSE methods are most applicable when detail retention and contour reconstruction are valued. == Methodology == === Pre-processing === Input images will typical contain more data than is necessary to generate an initial skeleton, and thus must be reduced in some way. Reducing the resolution, converting to grayscale, and then binary by masking or thresholding are common first steps. Noise removal may occur before and/or after converting an image to binary. Morphological operations such as closing, opening, and smoothing of the binary image may also be part of pre-processing. Ideally, the binarized contour should be as noise-free as possible before the skeleton is generated. === Skeletonization === DSE techniques may be applied to an existing skeleton or incorporated as part of the skeleton growing algorithm. Suitable skeletons may be obtained using a variety of methods: Thinning algorithms, such as the Grassfire transform Voronoi diagram Medial Axis Transform or Symmetry Axis Transform Distance Mapping === Significance Measures === DSE and related methods remove entire spurious branches while leaving the main trunk intact. The intended result is typically optimized for visual clarity and retention of information, such that the original contour can be reconstructed from the fully pruned skeleton. The value of various properties must be weighted by the application, and improving the efficiency is an ongoing topic of research in computer vision and image processing. Some significance measures include: Discrete Bisector Function Contour length Bending Potential Ratio Discrete Curve Evolution === Iteration === Each branch is evaluated during a pass through the skeletonized image according to the specific algorithm being used. Low value branches are removed and the process is repeated until a desired threshold of simplicity is reached. === Reconstruction === If all points on the output skeleton are the center points of maximal disks of the image and the radius information is retained, a contour image can be reconstructed == Applications == === Handwriting and text parsing === Variability in hand-written text is an ongoing challenge, simplification makes it somewhat easier for computer vision algorithms to make judgements about intended characters. === Soft body classification (animals) === The maximal disks centered on the skeleton imply roughly spherical masses, the features of the extracted skeleton are relatively unchanged even as the soft body deforms or self-occludes. Skeleton information is one facet of determining whether two animals are the "same" some way, though it must usually be paired with another technique to effectively identify a target. === Medical uses === Investigation of organs, tissue damage and deformation caused by disease.