In computer security, Capture the Flag (CTF) is an exercise in which participants attempt to find text strings, called "flags", which are secretly hidden in purposefully vulnerable programs or websites. They can be used for both competitive or educational purposes. In two main variations of CTFs, participants either steal flags from other participants (attack/defense-style CTFs) or from organizers (jeopardy-style challenges). A mixed competition combines these two styles. Competitions can include hiding flags in hardware devices, they can be both online or in-person, and can be advanced or entry-level. The game is inspired by the traditional outdoor sport with the same name. CTFs are used as a tool for developing and refining cybersecurity skills, making them popular in both professional and academic settings. == Overview == Capture the Flag (CTF) is a cybersecurity competition that is used to test and develop computer security skills. It was first developed in 1996 at DEF CON, the largest cybersecurity conference in the United States which is hosted annually in Las Vegas, Nevada. The conference hosts a weekend of cybersecurity competitions, including their flagship CTF. Two popular CTF formats are jeopardy and attack-defense. Both formats test participant’s knowledge in cybersecurity, but differ in objective. In the Jeopardy format, participating teams must complete as many challenges of varying point values from a various categories such as cryptography, web exploitation, and reverse engineering. In the attack-defense format, competing teams must defend their vulnerable computer systems while attacking their opponent's systems. The exercise involves a diverse array of tasks, including exploitation and cracking passwords, but there is little evidence showing how these tasks translate into cybersecurity knowledge held by security experts. Recent research has shown that the Capture the Flag tasks mainly covered technical knowledge but lacked social topics like social engineering and awareness on cybersecurity. == Educational applications == CTFs have been shown to be an effective way to improve cybersecurity education through gamification. There are many examples of CTFs designed to teach cybersecurity skills to a wide variety of audiences, including PicoCTF, organized by the Carnegie Mellon CyLab, which is oriented towards high school students, and Arizona State University supported pwn.college. Beyond educational CTF events and resources, CTFs has been shown to be a highly effective way to instill cybersecurity concepts in the classroom. CTFs have been included in undergraduate computer science classes such as Introduction to Information Security at the National University of Singapore. CTFs are also popular in military academies. They are often included as part of the curriculum for cybersecurity courses, with the NSA organized Cyber Exercise culminating in a CTF competition between the US service academies and military colleges. == Competitions == Many CTF organizers register their competition with the CTFtime platform. This allows the tracking of the position of teams over time and across competitions. These include "Plaid Parliament of Pwning", "More Smoked Leet Chicken", "Dragon Sector", "dcua", "Eat, Sleep, Pwn, Repeat", "perfect blue", "organizers" and "Blue Water". Overall the "Plaid Parliament of Pwning" and "Dragon Sector" have both placed first worldwide the most with three times each. === Community competitions === Every year there are dozens of CTFs organized in a variety of formats. Many CTFs are associated with cybersecurity conferences such as DEF CON, various editions of SANS Institute's NetWars, HITCON, and BSides. The DEF CON CTF, an attack-defence CTF, is notable for being one of the oldest CTF competitions to exist, and has been variously referred to as the "World Series", "Superbowl", and "Olympics", of hacking by media outlets. The NYU Tandon hosted Cybersecurity Awareness Worldwide (CSAW) CTF is one of the largest open-entry competitions for students learning cybersecurity from around the world. In 2021, it hosted over 1200 teams during the qualification round. In addition to conference organized CTFs, many CTF clubs and teams organize CTF competitions. Many CTF clubs and teams are associated with universities, such as the CMU associated Plaid Parliament of Pwning, which hosts PlaidCTF, and the ASU associated Shellphish. Some community CTFs are online and open to all participants. The SANS Institute Holiday Hack Challenge and TryHackMe Advent of Cyber. === Government-supported competitions === Governmentally supported CTF competitions include the DARPA Cyber Grand Challenge and ENISA European Cybersecurity Challenge. In 2023, the US Space Force-sponsored Hack-a-Sat CTF competition included, for the first time, a live orbital satellite for participants to exploit. === Corporate-supported competitions === Corporations and other organizations sometimes use CTFs as a training or evaluation exercise, with benefits similar to those in educational settings. In addition to internal CTF exercises, some corporations such as Google and Tencent host publicly accessible CTF competitions. == In popular culture == In Mr. Robot, a qualification round for the DEF CON CTF competition is depicted in the season 3 opener "eps3.0_power-saver-mode.h". The logo for DEF CON can be seen in the background. In The Undeclared War, a CTF is depicted in the opening scene of the series as a recruitment exercise used by GCHQ. Go Go Squid!, a Chinese television series, is based around training for and competing in highly stylized CTF competitions .
Night Sky (app)
Night Sky (app) is an application developed and published by indie studio iCandi Apps Ltd. from the UK. Night Sky is a stargazing reference app, where the user can explore a virtual representation of the night sky to identify stars, planets, constellations and satellites. The app is developed specifically for iOS, tvOS and watchOS devices. Night Sky was first released on November 1, 2011 for iOS, and has had multiple updates since launch. Night Sky was mentioned in the September 2016 Apple Keynote during the Apple Watch Series 2 announcement. In October 2016, Night Sky was featured as the Free App of The Week on the Apple App Store. == Reception == Night Sky was featured in Apple's 'Best of 2012' and has also been pre-installed onto iPads in Apple retail stores worldwide.
Synthetic data
Synthetic data are artificially generated data not produced by real-world events. Typically created using algorithms, synthetic data can be deployed to validate mathematical models and to train machine learning models. Data generated by a computer simulation can be seen as synthetic data. This encompasses most applications of physical modeling, such as music synthesizers or flight simulators. The output of such systems approximates the real thing, but is fully algorithmically generated. Synthetic data is used in a variety of fields as a filter for information that would otherwise compromise the confidentiality of particular aspects of the data. In many sensitive applications, datasets theoretically exist but cannot be released to the general public; synthetic data sidesteps the privacy issues that arise from using real consumer information without permission or compensation. == Usefulness == Synthetic data is generated to meet specific needs or certain conditions that may not be found in the original, real data. One of the hurdles in applying up-to-date machine learning approaches for complex scientific tasks is the scarcity of labeled data, a gap effectively bridged by the use of synthetic data, which closely replicates real experimental data. This can be useful when designing many systems, from simulations based on theoretical value, to database processors, etc. This helps detect and solve unexpected issues such as information processing limitations. Synthetic data are often generated to represent the authentic data and allows a baseline to be set. Another benefit of synthetic data is to protect the privacy and confidentiality of authentic data, while still allowing for use in testing systems. Computer security experts claim generated synthetic data "... enables us to create realistic behavior profiles for users and attackers. The data is used to train the fraud detection system itself, thus creating the necessary adaptation of the system to a specific environment." In defense and military contexts, synthetic data is seen as a potentially valuable tool to develop and improve complex AI systems, particularly in contexts where high-quality real-world data is scarce. At the same time, synthetic data together with the testing approach can give the ability to model real-world scenarios. == History == Scientific modelling of physical systems has a long history that runs concurrent with the history of physics. For example, research into synthesis of audio and voice can be traced back to the 1930s and before, driven forward by the developments of the telephone and audio recording technologies. Digitization gave rise to software synthesizers from the 1970s onwards. In the context of privacy-preserving statistical analysis, in 1993, the idea of original fully synthetic data was created by Donald Rubin. Rubin originally designed this to synthesize the Decennial Census long form responses for the short form households. He then released samples that did not include any actual long form records - in this he preserved anonymity of the household. Later that year, the idea of original partially synthetic data was created by Little. Little used this idea to synthesize the sensitive values on the public use file. A 1993 work fitted a statistical model to 60,000 MNIST digits, then it was used to generate over 1 million examples. Those were used to train a LeNet-4 to reach state of the art performance. In 1994, Stephen Fienberg introduced 'critical refinement', in which a parametric posterior predictive distribution (instead of a Bayes bootstrap) is used to do the sampling. Later, other important contributors to the development of synthetic data generation were Trivellore Raghunathan, Jerry Reiter, Donald Rubin, John M. Abowd, and Jim Woodcock. Collectively they came up with a solution for how to treat partially synthetic data with missing data. Similarly, they developed the technique of Sequential Regression Multivariate Imputation. == Calculations == Researchers test the framework on synthetic data, which is "the only source of ground truth on which they can objectively assess the performance of their algorithms". Synthetic data can be generated through the use of random lines, having different orientations and starting positions. Datasets can get fairly complicated. A more complicated dataset can be generated by using a synthesizer build. To create a synthesizer build, first use the original data to create a model or equation that fits the data the best. This model or equation will be called a synthesizer build. This build can be used to generate more data. Constructing a synthesizer build involves constructing a statistical model. In a linear regression line example, the original data can be plotted, and a best fit linear line can be created from the data. This line is a synthesizer created from the original data. The next step will be generating more synthetic data from the synthesizer build or from this linear line equation. In this way, the new data can be used for studies and research, and it protects the confidentiality of the original data. David Jensen from the Knowledge Discovery Laboratory explains how to generate synthetic data: "Researchers frequently need to explore the effects of certain data characteristics on their data model." To help construct datasets exhibiting specific properties, such as auto-correlation or degree disparity, proximity can generate synthetic data having one of several types of graph structure: random graphs that are generated by some random process; lattice graphs having a ring structure; lattice graphs having a grid structure, etc. In all cases, the data generation process follows the same process: Generate the empty graph structure. Generate attribute values based on user-supplied prior probabilities. Since the attribute values of one object may depend on the attribute values of related objects, the attribute generation process assigns values collectively. == Applications == === Fraud detection and confidentiality systems === Testing and training fraud detection and confidentiality systems are devised using synthetic data. Specific algorithms and generators are designed to create realistic data, which then assists in teaching a system how to react to certain situations or criteria. For example, intrusion detection software is tested using synthetic data. This data is a representation of the authentic data and may include intrusion instances that are not found in the authentic data. The synthetic data allows the software to recognize these situations and react accordingly. If synthetic data was not used, the software would only be trained to react to the situations provided by the authentic data and it may not recognize another type of intrusion. === Scientific research === Researchers doing clinical trials or any other research may generate synthetic data to aid in creating a baseline for future studies and testing. Real data can contain information that researchers may not want released, so synthetic data is sometimes used to protect the privacy and confidentiality of a dataset. Using synthetic data reduces confidentiality and privacy issues since it holds no personal information and cannot be traced back to any individual. Beyond privacy protection, synthetic data is also being explored for methodological innovation in drug development. For instance, synthetic data may be used to construct synthetic control arms as an alternative to conventional external control arms based on real-world data (RWD) or randomized controlled trials (RCTs). Collectively, regulatory agencies such as the FDA and EMA appear to be at various stages of recognizing and integrating AI-generated synthetic data into their methodologies. While there is growing consensus on the potential of such data to support model development and the broader lifecycle of medicinal products, to date no drug or medical device has been approved using solely or predominantly synthetic data—particularly not as a comparator arm generated entirely via data-driven algorithms. The quality and statistical handling of synthetic data are expected to become more prominent in future regulatory discussions, particularly in contexts such as predictive modeling (e.g., digital twins), where innovative approaches have already been referenced. === Machine learning === Synthetic data is increasingly being used for machine learning applications: a model is trained on a synthetically generated dataset with the intention of transfer learning to real data. Efforts have been made to enable more data science experiments via the construction of general-purpose synthetic data generators, such as the Synthetic Data Vault. In general, synthetic data has several natural advantages: once the synthetic environment is ready, it is fast and cheap to produce as much data as needed; synthetic data can have perfectly accurate labels, including labeling that may be very expensive or impo
Time Warp Edit Distance
In the data analysis of time series, Time Warp Edit Distance (TWED) is a measure of similarity (or dissimilarity) between pairs of discrete time series, controlling the relative distortion of the time units of the two series using the physical notion of elasticity. In comparison to other distance measures, (e.g. DTW (dynamic time warping) or LCS (longest common subsequence problem)), TWED is a metric. Its computational time complexity is O ( n 2 ) {\displaystyle O(n^{2})} , but can be drastically reduced in some specific situations by using a corridor to reduce the search space. Its memory space complexity can be reduced to O ( n ) {\displaystyle O(n)} . It was first proposed in 2009 by P.-F. Marteau. == Definition == δ λ , ν ( A 1 p , B 1 q ) = M i n { δ λ , ν ( A 1 p − 1 , B 1 q ) + Γ ( a p ′ → Λ ) d e l e t e i n A δ λ , ν ( A 1 p − 1 , B 1 q − 1 ) + Γ ( a p ′ → b q ′ ) m a t c h o r s u b s t i t u t i o n δ λ , ν ( A 1 p , B 1 q − 1 ) + Γ ( Λ → b q ′ ) d e l e t e i n B {\displaystyle \delta _{\lambda ,\nu }(A_{1}^{p},B_{1}^{q})=Min{\begin{cases}\delta _{\lambda ,\nu }(A_{1}^{p-1},B_{1}^{q})+\Gamma (a_{p}^{'}\to \Lambda )&{\rm {delete\ in\ A}}\\\delta _{\lambda ,\nu }(A_{1}^{p-1},B_{1}^{q-1})+\Gamma (a_{p}^{'}\to b_{q}^{'})&{\rm {match\ or\ substitution}}\\\delta _{\lambda ,\nu }(A_{1}^{p},B_{1}^{q-1})+\Gamma (\Lambda \to b_{q}^{'})&{\rm {delete\ in\ B}}\end{cases}}} whereas Γ ( α p ′ → Λ ) = d L P ( a p ′ , a p − 1 ′ ) + ν ⋅ ( t a p − t a p − 1 ) + λ {\displaystyle \Gamma (\alpha _{p}^{'}\to \Lambda )=d_{LP}(a_{p}^{'},a_{p-1}^{'})+\nu \cdot (t_{a_{p}}-t_{a_{p-1}})+\lambda } Γ ( α p ′ → b q ′ ) = d L P ( a p ′ , b q ′ ) + d L P ( a p − 1 ′ , b q − 1 ′ ) + ν ⋅ ( | t a p − t b q | + | t a p − 1 − t b q − 1 | ) {\displaystyle \Gamma (\alpha _{p}^{'}\to b_{q}^{'})=d_{LP}(a_{p}^{'},b_{q}^{'})+d_{LP}(a_{p-1}^{'},b_{q-1}^{'})+\nu \cdot (|t_{a_{p}}-t_{b_{q}}|+|t_{a_{p-1}}-t_{b_{q-1}}|)} Γ ( Λ → b q ′ ) = d L P ( b p ′ , b p − 1 ′ ) + ν ⋅ ( t b q − t b q − 1 ) + λ {\displaystyle \Gamma (\Lambda \to b_{q}^{'})=d_{LP}(b_{p}^{'},b_{p-1}^{'})+\nu \cdot (t_{b_{q}}-t_{b_{q-1}})+\lambda } Whereas the recursion δ λ , ν {\displaystyle \delta _{\lambda ,\nu }} is initialized as: δ λ , ν ( A 1 0 , B 1 0 ) = 0 , {\displaystyle \delta _{\lambda ,\nu }(A_{1}^{0},B_{1}^{0})=0,} δ λ , ν ( A 1 0 , B 1 j ) = ∞ f o r j ≥ 1 {\displaystyle \delta _{\lambda ,\nu }(A_{1}^{0},B_{1}^{j})=\infty \ {\rm {{for\ }j\geq 1}}} δ λ , ν ( A 1 i , B 1 0 ) = ∞ f o r i ≥ 1 {\displaystyle \delta _{\lambda ,\nu }(A_{1}^{i},B_{1}^{0})=\infty \ {\rm {{for\ }i\geq 1}}} with a 0 ′ = b 0 ′ = 0 {\displaystyle a'_{0}=b'_{0}=0} === Implementations === An implementation of the TWED algorithm in C with a Python wrapper is available at TWED is also implemented into the Time Series Subsequence Search Python package (TSSEARCH for short) available at [1]. An R implementation of TWED has been integrated into the TraMineR, a R package for mining, describing and visualizing sequences of states or events, and more generally discrete sequence data. Additionally, cuTWED is a CUDA- accelerated implementation of TWED which uses an improved algorithm due to G. Wright (2020). This method is linear in memory and massively parallelized. cuTWED is written in CUDA C/C++, comes with Python bindings, and also includes Python bindings for Marteau's reference C implementation. ==== Python ==== Backtracking, to find the most cost-efficient path: ==== MATLAB ==== Backtracking, to find the most cost-efficient path:
Magic state distillation
Magic state distillation is a method for creating more accurate quantum states from multiple noisy ones, which is important for building fault tolerant quantum computers. It has also been linked to quantum contextuality, a concept thought to contribute to quantum computers' power. The technique was first proposed by Emanuel Knill in 2004, and further analyzed by Sergey Bravyi and Alexei Kitaev the same year. Thanks to the Gottesman–Knill theorem, it is known that some quantum operations (operations in the Clifford group) can be perfectly simulated in polynomial time on a classical computer. In order to achieve universal quantum computation, a quantum computer must be able to perform operations outside this set. Magic state distillation achieves this, in principle, by concentrating the usefulness of imperfect resources, represented by mixed states, into states that are conducive for performing operations that are difficult to simulate classically. A variety of qubit magic state distillation routines and distillation routines for qubits with various advantages have been proposed. == Stabilizer formalism == The Clifford group consists of a set of n {\displaystyle n} -qubit operations generated by the gates {H, S, CNOT} (where H is Hadamard and S is [ 1 0 0 i ] {\displaystyle {\begin{bmatrix}1&0\\0&i\end{bmatrix}}} ) called Clifford gates. The Clifford group generates stabilizer states which can be efficiently simulated classically, as shown by the Gottesman–Knill theorem. This set of gates with a non-Clifford operation is universal for quantum computation. == Magic states == Magic states are purified from n {\displaystyle n} copies of a mixed state ρ {\displaystyle \rho } . These states are typically provided via an ancilla to the circuit. A magic state for the π / 6 {\displaystyle \pi /6} rotation operator is | M ⟩ = cos ( β / 2 ) | 0 ⟩ + e i π 4 sin ( β / 2 ) | 1 ⟩ {\displaystyle |M\rangle =\cos(\beta /2)|0\rangle +e^{i{\frac {\pi }{4}}}\sin(\beta /2)|1\rangle } where β = arccos ( 1 3 ) {\displaystyle \beta =\arccos \left({\frac {1}{\sqrt {3}}}\right)} . A non-Clifford gate can be generated by combining (copies of) magic states with Clifford gates. Since a set of Clifford gates combined with a non-Clifford gate is universal for quantum computation, magic states combined with Clifford gates are also universal. == Purification algorithm for distilling |M〉 == The first magic state distillation algorithm, invented by Sergey Bravyi and Alexei Kitaev, is as follows. Input: Prepare 5 imperfect states. Output: An almost pure state having a small error probability. repeat Apply the decoding operation of the five-qubit error correcting code and measure the syndrome. If the measured syndrome is | 0000 ⟩ {\displaystyle |0000\rangle } , the distillation attempt is successful. else Get rid of the resulting state and restart the algorithm. until The states have been distilled to the desired purity.
Biohybrid microswimmer
A biohybrid microswimmer also known as biohybrid nanorobot, can be defined as a microswimmer that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. In recent years nanoscopic and mesoscopic objects have been designed to collectively move through direct inspiration from nature or by harnessing its existing tools. Small mesoscopic to nanoscopic systems typically operate at low Reynolds numbers (Re ≪ 1), and understanding their motion becomes challenging. For locomotion to occur, the symmetry of the system must be broken. In addition, collective motion requires a coupling mechanism between the entities that make up the collective. To develop mesoscopic to nanoscopic entities capable of swarming behaviour, it has been hypothesised that the entities are characterised by broken symmetry with a well-defined morphology, and are powered with some material capable of harvesting energy. If the harvested energy results in a field surrounding the object, then this field can couple with the field of a neighbouring object and bring some coordination to the collective behaviour. Such robotic swarms have been categorised by an online expert panel as among the 10 great unresolved group challenges in the area of robotics. Although investigation of their underlying mechanism of action is still in its infancy, various systems have been developed that are capable of undergoing controlled and uncontrolled swarming motion by harvesting energy (e.g., light, thermal, etc.). Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. == Background == Biohybrid microswimmers can be defined as microswimmers that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. The pioneers of this field, ahead of their time, were Montemagno and Bachand with a 1999 work regarding specific attachment strategies of biological molecules to nanofabricated substrates enabling the preparation of hybrid inorganic/organic nanoelectromechanical systems, so called NEMS. They described the production of large amounts of F1-ATPase from the thermophilic bacteria Bacillus PS3 for the preparation of F1-ATPase biomolecular motors immobilized on a nanoarray pattern of gold, copper or nickel produced by electron beam lithography. These proteins were attached to one micron microspheres tagged with a synthetic peptide. Consequently, they accomplished the preparation of a platform with chemically active sites and the development of biohybrid devices capable of converting energy of biomolecular motors into useful work. One of the most fundamental questions in science is what defines life. Collective motion is one of the hallmarks of life. This is commonly observed in nature at various dimensional levels as energized entities gather, in a concerted effort, into motile aggregated patterns. These motile aggregated events can be noticed, among many others, as dynamic swarms; e.g., unicellular organisms such as bacteria, locust swarms, or the flocking behaviour of birds. Ever since Newton established his equations of motion, the mystery of motion on the microscale has emerged frequently in scientific history, as famously demonstrated by a couple of articles that should be discussed briefly. First, an essential concept, popularized by Osborne Reynolds, is that the relative importance of inertia and viscosity for the motion of a fluid depends on certain details of the system under consideration. The Reynolds number Re, named in his honor, quantifies this comparison as a dimensionless ratio of characteristic inertial and viscous forces: R e = ρ u l μ {\displaystyle \mathrm {Re} ={\frac {\rho ul}{\mu }}} Here, ρ represents the density of the fluid; u is a characteristic velocity of the system (for instance, the velocity of a swimming particle); l is a characteristic length scale (e.g., the swimmer size); and μ is the viscosity of the fluid. Taking the suspending fluid to be water, and using experimentally observed values for u, one can determine that inertia is important for macroscopic swimmers like fish (Re = 100), while viscosity dominates the motion of microscale swimmers like bacteria (Re = 10−4). The overwhelming importance of viscosity for swimming at the micrometer scale has profound implications for swimming strategy. This has been discussed memorably by E. M. Purcell, who invited the reader into the world of microorganisms and theoretically studied the conditions of their motion. In the first place, propulsion strategies of large scale swimmers often involve imparting momentum to the surrounding fluid in periodic discrete events, such as vortex shedding, and coasting between these events through inertia. This cannot be effective for microscale swimmers like bacteria: due to the large viscous damping, the inertial coasting time of a micron-sized object is on the order of 1 μs. The coasting distance of a microorganism moving at a typical speed is about 0.1 angstroms (Å). Purcell concluded that only forces that are exerted in the present moment on a microscale body contribute to its propulsion, so a constant energy conversion method is essential. Microorganisms have optimized their metabolism for continuous energy production, while purely artificial microswimmers (microrobots) must obtain energy from the environment, since their on-board-storage-capacity is very limited. As a further consequence of the continuous dissipation of energy, biological and artificial microswimmers do not obey the laws of equilibrium statistical physics, and need to be described by non-equilibrium dynamics. Mathematically, Purcell explored the implications of low Reynolds number by taking the Navier-Stokes equation and eliminating the inertial terms: μ ∇ 2 u − ∇ p = 0 {\displaystyle {\begin{aligned}\mu \nabla ^{2}\mathbf {u} -{\boldsymbol {\nabla }}p&={\boldsymbol {0}}\\\end{aligned}}} where u {\displaystyle \mathbf {u} } is the velocity of the fluid and ∇ p {\displaystyle {\boldsymbol {\nabla }}p} is the gradient of the pressure. As Purcell noted, the resulting equation — the Stokes equation — contains no explicit time dependence. This has some important consequences for how a suspended body (e.g., a bacterium) can swim through periodic mechanical motions or deformations (e.g., of a flagellum). First, the rate of motion is practically irrelevant for the motion of the microswimmer and of the surrounding fluid: changing the rate of motion will change the scale of the velocities of the fluid and of the microswimmer, but it will not change the pattern of fluid flow. Secondly, reversing the direction of mechanical motion will simply reverse all velocities in the system. These properties of the Stokes equation severely restrict the range of feasible swimming strategies. Recent publications of biohybrid microswimmers include the use of sperm cells, contractive muscle cells, and bacteria as biological components, as they can efficiently convert chemical energy into movement, and additionally are capable of performing complicated motion depending on environmental conditions. In this sense, biohybrid microswimmer systems can be described as the combination of different functional components: cargo and carrier. The cargo is an element of interest to be moved (and possibly released) in a customized way. The carrier is the component responsible for the movement of the biohybrid, transporting the desired cargo, which is linked to its surface. The great majority of these systems rely on biological motile propulsion for the transportation of synthetic cargo for targeted drug delivery/ There are also examples of the opposite case: artificial microswimmers with biological cargo systems. Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. Active locomotion, targeting and steering of concentrated therape
VMDS
VMDS abbreviates the relational database technology called Version Managed Data Store provided by GE Energy as part of its Smallworld technology platform and was designed from the outset to store and analyse the highly complex spatial and topological networks typically used by enterprise utilities such as power distribution and telecommunications. VMDS was originally introduced in 1990 as has been improved and updated over the years. Its current version is 6.0. VMDS has been designed as a spatial database. This gives VMDS a number of distinctive characteristics when compared to conventional attribute only relational databases. == Distributed server processing == VMDS is composed of two parts: a simple, highly scalable data block server called SWMFS (Smallworld Master File Server) and an intelligent client API written in C and Magik. Spatial and attribute data are stored in data blocks that reside in special files called data store files on the server. When the client application requests data it has sufficient intelligence to work out the optimum set of data blocks that are required. This request is then made to SWMFS which returns the data to the client via the network for processing. This approach is particularly efficient and scalable when dealing with spatial and topological data which tends to flow in larger volumes and require more processing then plain attribute data (for example during a map redraw operation). This approach makes VMDS well suited to enterprise deployment that might involve hundreds or even thousands of concurrent clients. == Support for long transactions == Relational databases support short transactions in which changes to data are relatively small and are brief in terms in duration (the maximum period between the start and the end of a transaction is typically a few seconds or less). VMDS supports long transactions in which the volume of data involved in the transaction can be substantial and the duration of the transaction can be significant (days, weeks or even months). These types of transaction are common in advanced network applications used by, for example, power distribution utilities. Due to the time span of a long transaction in this context the amount of change can be significant (not only within the scope of the transaction, but also within the context of the database as a whole). Accordingly, it is likely that the same record might be changed more than once. To cope with this scenario VMDS has inbuilt support for automatically managing such conflicts and allows applications to review changes and accept only those edits that are correct. == Spatial and topological capabilities == As well as conventional relational database features such as attribute querying, join fields, triggers and calculated fields, VMDS has numerous spatial and topological capabilities. This allows spatial data such as points, texts, polylines, polygons and raster data to be stored and analysed. Spatial functions include: find all features within a polygon, calculate the Voronoi polygons of a set of sites and perform a cluster analysis on a set of points. Vector spatial data such as points, polylines and polygons can be given topological attributes that allow complex networks to be modelled. Network analysis engines are provided to answer questions such as find the shortest path between two nodes or how to optimize a delivery route (the travelling salesman problem). A topology engine can be configured with a set of rules that define how topological entities interact with each other when new data is added or existing data edited. == Data abstraction == In VMDS all data is presented to the application as objects. This is different from many relational databases that present the data as rows from a table or query result using say JDBC. VMDS provides a data modelling tool and underlying infrastructure as part of the Smallworld technology platform that allows administrators to associate a table in the database with a Magik exemplar (or class). Magik get and set methods for the Magik exemplar can be automatically generated that expose a table's field (or column). Each VMDS row manifests itself to the application as an instance of a Magik object and is known as an RWO (or real world object). Tables are known as collections in Smallworld parlance. # all_rwos hold all the rwos in the database and is heterogeneous all_rwos << my_application.rwo_set() # valve_collection holds the valve collection valves << all_rwos.select(:collection, {:valve}) number_of_valves << valves.size Queries are built up using predicate objects: # find 'open' valves. open_valves << valves.select(predicate.eq(:operating_status, "open")) number_of_open_valves << open_valves.size _for valve _over open_valves.elements() _loop write(valve.id) _endloop Joins are implemented as methods on the parent RWO. For example, a manager might have several employees who report to him: # get the employee collection. employees << my_application.database.collection(:gis, :employees) # find a manager called 'Steve' and get the first matching element steve << employees.select(predicate.eq(:name, "Steve").and(predicate.eq(:role, "manager")).an_element() # display the names of his direct reports. name is a field (or column) # on the employee collection (or table) _for employee _over steve.direct_reports.elements() _loop write(employee.name) _endloop Performing a transaction: # each key in the hash table corresponds to the name of the field (or column) in # the collection (or table) valve_data << hash_table.new_with( :asset_id, 57648576, :material, "Iron") # get the valve collection directly valve_collection << my_application.database.collection(:gis, :valve) # create an insert transaction to insert a new valve record into the collection a # comment can be provide that describes the transaction transaction << record_transaction.new_insert(valve_collection, valve_data, "Inserted a new valve") transaction.run()