An automated dispensing cabinet (ADC), also called a unit-based cabinet (UBC), automated dispensing device (ADD), or automated dispensing machine (ADM)[1], is a computerized medicine cabinet for hospitals and healthcare settings. ADCs allow medications to be stored and dispensed near the point of care while controlling and tracking drug distribution. == Overview == Hospital pharmacies have provided medications for patients by filling patient-specific cassettes of unit-dose medications that were then delivered to the nursing unit and stored in medication cabinets or carts. ADCs, originally designed for hospital use, were introduced in hospitals in the 1980s and have facilitated the transition to alternative delivery models and more decentralized medication distribution systems.[2] Implementing automated dispensing cabinets as part of a decentralized or hybrid medication distribution system can improve patient safety and the accountability of the inventory, streamline certain billing processes. However, in the 2000s, the technology began to be deployed into other care settings where medication doses were stored onsite, and higher security methods were needed to control inventory, access, and dispensing of each patient dose. Settings that now deploy ADCs include long-term care facilities, hospice, critical access hospitals, surgery centers, group homes, residential care facilities, rehab and psych environments, animal health, dental clinics, and nursing education simulation. These diverse care settings share a common need to safely store, account for, and dispense individual doses of medications, especially narcotics and high-value medications, at the point of care.[3] ADCs track user access and dispensed medications, and their use can improve control over medication inventory. The real-time inventory reports generated by many cabinets can simplify the filling process and help the pharmacy track expired drugs. Furthermore, by restricting individual drugs – such as high-risk medications and controlled substances – to unique drawers within the cabinet, overall inventory management, patient safety, and medication security can be improved. Automated dispensing cabinets allow the pharmacy department to profile physician orders before they are dispensed.[4] ADCs can also enable providers to record medication charges upon dispensing, reducing the billing paperwork the pharmacy is responsible for. In addition, nurses can note returned medications using the cabinets' computers, enabling direct credits to patients' accounts. Since automated cabinets can be located on the nursing unit floor, nursing have speedier access to a patient's medications. Also, shorter waiting time ensures improved patient comfort and care.[5] == Role of automated dispensing in healthcare == Automated dispensing is a pharmacy practice in which a device dispenses medications and fills prescriptions. ADCs, which can handle many different medications, are available from a number of manufacturers such as BD, ARxIUM, and Omnicell. Though members of the pharmacy community have been utilizing automation technology since the 1980s, companies are constantly improving ADCs to meet changing needs and health standards in the industry. Several goals can be met by implementing an automated product in a healthcare facility. Patient safety can be ensured with the use of ADC technology such as barcoding. Anesthesia ADCs in operating rooms and perioperative areas may include label printing to prevent mix-ups such as errors between morphine and hydromorphone, two different opioid analgesics that frequently get confused. These systems also communicate with the pharmacy and its information management system to track medications removed and support inventory replenishment. == Key features == ADCs are like automated teller machines whose specific technologies such as barcode scanning and clinical decision support can improve medication safety. Some have metal locking drawers for added security and some have automated single-dose dispensing to prevent the need for a blind count each time a controlled substance is accessed. Over the years, ADCs have been adapted to facilitate compliance with emerging regulatory requirements such as pharmacy review of medication orders and safe practice recommendations. ADCs incorporate advanced software and electronic interfaces to synthesize high-risk steps in the medication use process. These unit-based medication repositories provide computer-controlled storage, dispensation, tracking, and documentation of medication distribution in the resident care unit. Since automated dispensing cabinets are not located in the pharmacy, they are considered "decentralized" medication distribution systems. Instead, they can be found at the point of care on the resident care unit. Tracking of the stocking and distribution process can occur by interfacing the unit with a central pharmacy computer. These cabinets can also be interfaced with other external databases such as resident profiles, the facility's admission/discharge/transfer system, and billing systems. Most ADC providers offer scalable systems since several important factors vary widely by facility such as budget, physical room size, patient population/demographics, type of healthcare facility, etc.
Photometric stereo
Photometric stereo is a technique in computer vision for estimating the surface normals of objects by observing that object under different lighting conditions (photometry). It is based on the fact that the amount of light reflected by a surface is dependent on the orientation of the surface in relation to the light source and the observer. By measuring the amount of light reflected into a camera, the space of possible surface orientations is limited. Given enough light sources from different angles, the surface orientation may be constrained to a single orientation or even overconstrained. The technique was originally introduced by Woodham in 1980. The special case where the data is a single image is known as shape from shading, and was analyzed by B. K. P. Horn in 1989. Photometric stereo has since been generalized to many other situations, including extended light sources and non-Lambertian surface finishes. Current research aims to make the method work in the presence of projected shadows, highlights, and non-uniform lighting. Photometric stereo is widely used in various fields, including archaeology, cultural heritage conservation, and quality control. It is now integrated into widely used open-source software, such as Meshroom. == Basic method == Under Woodham's original assumptions — Lambertian reflectance, known point-like distant light sources, and uniform albedo — the problem can be solved by inverting the linear equation I = L ⋅ n {\displaystyle I=L\cdot n} , where I {\displaystyle I} is a (known) vector of m {\displaystyle m} observed intensities, n {\displaystyle n} is the (unknown) surface normal, and L {\displaystyle L} is a (known) 3 × m {\displaystyle 3\times m} matrix of normalized light directions. This model can easily be extended to surfaces with non-uniform albedo, while keeping the problem linear. Taking an albedo reflectivity of k {\displaystyle k} , the formula for the reflected light intensity becomes I = k ( L ⋅ n ) . {\displaystyle I=k(L\cdot n).} If L {\displaystyle L} is square (there are exactly 3 lights) and non-singular, it can be inverted, giving L − 1 I = k n . {\displaystyle L^{-1}I=kn.} Since the normal vector is known to have length 1, k {\displaystyle k} must be the length of the vector k n {\displaystyle kn} , and n {\displaystyle n} is the normalised direction of that vector. If L {\displaystyle L} is not square (there are more than 3 lights), a generalisation of the inverse can be obtained using the Moore–Penrose pseudoinverse, by simply multiplying both sides with L T {\displaystyle L^{T}} , giving L T I = L T k ( L ⋅ n ) , {\displaystyle L^{T}I=L^{T}k(L\cdot n),} ( L T L ) − 1 L T I = k n , {\displaystyle (L^{T}L)^{-1}L^{T}I=kn,} after which the normal vector and albedo can be solved as described above. == Non-Lambertian surfaces == The classical photometric stereo problem concerns itself only with Lambertian surfaces, with perfectly diffuse reflection. This is unrealistic for many types of materials, especially metals, glass and smooth plastics, and will lead to aberrations in the resulting normal vectors. Many methods have been developed to lift this assumption. In this section, a few of these are listed. === Specular reflections === Historically, in computer graphics, the commonly used model to render surfaces started with Lambertian surfaces and progressed first to include simple specular reflections. Computer vision followed a similar course with photometric stereo. Specular reflections were among the first deviations from the Lambertian model. These are a few adaptations that have been developed. Many techniques ultimately rely on modelling the reflectance function of the surface, that is, how much light is reflected in each direction. This reflectance function has to be invertible. The reflected light intensities towards the camera is measured, and the inverse reflectance function is fit onto the measured intensities, resulting in a unique solution for the normal vector. === General BRDFs and beyond === According to the Bidirectional reflectance distribution function (BRDF) model, a surface may distribute the amount of light it receives in any outward direction. This is the most general known model for opaque surfaces. Some techniques have been developed to model (almost) general BRDFs. In practice, all of these require many light sources to obtain reliable data. These are methods in which surfaces with general BRDFs can be measured. Determine the explicit BRDF prior to scanning. To do this, a different surface is required that has the same or a very similar BRDF, of which the actual geometry (or at least the normal vectors for many points on the surface) is already known. The lights are then individually shone upon the known surface, and the amount of reflection into the camera is measured. Using this information, a look-up table can be created that maps reflected intensities for each light source to a list of possible normal vectors. This puts constraints on the possible normal vectors the surface may have, and reduces the photometric stereo problem to an interpolation between measurements. Typical known surfaces to calibrate the look-up table with are spheres for their wide variety of surface orientations. Restricting the BRDF to be symmetrical. If the BRDF is symmetrical, the direction of the light can be restricted to a cone about the direction to the camera. Which cone this is depends on the BRDF itself, the normal vector of the surface, and the measured intensity. Given enough measured intensities and the resulting light directions, these cones can be approximated and therefore the normal vectors of the surface. Some progress has been made towards modelling an even more general surfaces, such as Spatially Varying Bidirectional Distribution Functions (SVBRDF), Bidirectional surface scattering reflectance distribution functions (BSSRDF), and accounting for interreflections. However, such methods are still fairly restrictive in photometric stereo. Better results have been achieved with structured light. == Uncalibrated photometric stereo == Uncalibrated Photometric Stereo is an approach in photometric stereo that aims to reconstruct the 3D shape of an object from images captured under unknown lighting conditions. Unlike classical methods, which often assume controlled or known lighting setups, this approach removes these constraints, making it adaptable to diverse and real-world environments. The advent of deep learning has revolutionized universal PS by replacing handcrafted assumptions with data-driven models. Recent approaches leverage Transformer-based architectures and multi-scale encoder–decoder networks to directly estimate surface normals from input images. Uncalibrated Photometric Stereo is inherently an ill-posed problem, as it attempts to recover 3D shape and lighting conditions simultaneously from images alone. This leads to fundamental ambiguities in the reconstruction process, which manifest as systematic errors in the recovered geometry, including global distortions in the object's overall shape, and misinterpretation of surface orientation, where concave regions may appear convex and vice versa. To address the challenges of uncalibrated photometric stereo, hybrid methods have emerged that combine multi-view stereo and photometric stereo. These approaches leverage the strengths of both techniques, including geometric reliability and resolution.
Paradigms of AI Programming
Paradigms of AI Programming: Case Studies in Common Lisp (ISBN 1-55860-191-0) is a well-known programming book by Peter Norvig about artificial intelligence programming using Common Lisp. == History == The Lisp programming language has survived since 1958 as a primary language for artificial intelligence research. This text was published in 1992 as the Common Lisp standard was becoming widely adopted. Norvig introduces Lisp programming in the context of classic AI programs, including General Problem Solver (GPS) from 1959, ELIZA: Dialog with a Machine, from 1966, and STUDENT: Solving Algebra Word Problems, from 1964. The book covers more recent AI programming techniques, including Logic Programming, Object-Oriented Programming, Knowledge Representation, Symbolic Mathematics and Expert Systems.
GermaNet
GermaNet is a semantic network for the German language. It relates nouns, verbs, and adjectives semantically by grouping lexical units that express the same concept into synsets and by defining semantic relations between these synsets. GermaNet is free for academic use, after signing a license. GermaNet shares much in common with the English WordNet and can be viewed as an online thesaurus or a light-weight ontology. GermaNet has been developed and maintained at the University of Tübingen since 1997 within the research group for General and Computational Linguistics. It has been integrated into the EuroWordNet, a multilingual lexical-semantic database. == Database == === Contents === GermaNet partitions the lexical space into a set of concepts that are interlinked by semantic relations. A semantic concept is modeled by a synset. A synset is a set of words (called lexical units) where all the words are taken to have the same or almost the same meaning. Thus, a synset is a set of synonyms grouped under one definition, or "gloss". In addition to the gloss, synsets are labeled with their syntactic function and accompanied by example sentences for each distinct meaning in the synset. Just as in WordNet, for each word category the semantic space is divided into a number of semantic fields closely related to major nodes in the semantic network: Ort, or "location", Körper, or "body", etc. As of version 20.0 (release November 2025), GermaNet contains: Synsets: 179438 Lexical units: 231500 Literals: 216517 1.29 lexical units per synset Number of conceptual relations: 194367 Number of lexical relations: 13602 (synonymy excluded) Number of split compounds: 130901 Number of Interlingual Index (ILI) records: 28561 Number of Wiktionary sense descriptions: 29539 === Format === All GermaNet data is stored in a PostgreSQL relational database. The database schema follows the internal structure of GermaNet: there are tables to store synsets, lexical units, conceptual and lexical relations, etc. GermaNet data is distributed both in this database format and as XML files. In the XML data, two types of files, one for synsets and the other for relations, represent all data available in the GermaNet database. == Interfaces == There are software libraries and APIs available for Java and Python. These programs are distributed under free-software licenses and provide easy access to all information in various versions of GermaNet. GermaNet Rover is an on-line application that can be used to search for synsets in GermaNet, explore the data associated with them, and calculate the semantic similarity of pairs of synsets. It features visualizations of the hypernym relation and advanced filtering options for synset searching. == Licenses == GermaNet 20.0 (released November 2025) can be distributed under one of the following types of license agreements: Academic Research License Agreement: for the purpose of research at academic institutions. There is no license fee for academic use. Licenses are not given to individual students, and those seeking a license are required to talk to an academic advisor. Research and Development License Agreement: applies to non-academic institutions and research consortia. To be used strictly for technology development and internal research. Commercial License Agreement: applies to non-academic institutions and commercial enterprises. It permits technology development and internal research, as well as giving the non-exclusive right to distribute and market any derived product or service. == Alternatives == Open-de-WordNet is a freely available alternative to GermaNet which is compatible with WordNet. == Linguistic applications == GermaNet has been used for a variety of applications, including: semantic analysis shallow recognition of implicit document structure compound analysis analyzing sectional preferences word sense disambiguation
Chinese room
The Chinese room argument holds that a computer executing a program cannot have a mind, understanding, or consciousness, regardless of how intelligently or human-like the program may make the computer behave. The argument was presented in a 1980 paper by the American philosopher John Searle, entitled "Minds, Brains, and Programs" and published in the journal Behavioral and Brain Sciences. Similar arguments had been made previously by others, including Gottfried Wilhelm Leibniz, Peter Winch, and Anatoly Dneprov. Searle's version has been widely discussed in the years since. The centerpiece of Searle's argument is a thought experiment known as the "Chinese room". The argument is directed against the philosophical positions of functionalism and computationalism, which hold that the mind may be viewed as an information-processing system operating on formal symbols, and that simulation of a given mental state is sufficient for its presence. Specifically, the argument is intended to refute a position Searle calls the strong AI hypothesis: "The appropriately programmed computer with the right inputs and outputs would thereby have a mind in exactly the same sense human beings have minds." Although its proponents originally presented the argument in reaction to statements of artificial intelligence (AI) researchers, it is not an argument against the goals of mainstream AI research because it does not show a limit in the amount of intelligent behavior a machine can display. The argument applies only to digital computers running programs and does not apply to machines in general. While widely discussed, the argument has been subject to significant criticism and remains controversial among philosophers of mind and AI researchers. == Chinese room thought experiment == Suppose that artificial intelligence research has succeeded in programming a computer to behave as if it understands Chinese. The machine accepts Chinese characters as input, carries out each instruction of the program step by step, and then produces Chinese characters as output. The machine does this so perfectly that no one can tell that they are communicating with a machine and not a hidden Chinese speaker. The questions at issue are these: does the machine actually understand the conversation, or is it just simulating the ability to understand the conversation? Does the machine have a mind in exactly the same sense that people do, or is it just acting as if it had a mind? Now suppose that Searle is in a room with an English version of the program, along with sufficient pencils, paper, erasers and filing cabinets. Chinese characters are slipped in under the door, and he follows the program step-by-step, which eventually instructs him to slide other Chinese characters back out under the door. If the computer had passed the Turing test this way, it follows that Searle would do so as well, simply by running the program by hand. Searle can see no essential difference between the roles of the computer and himself in the experiment. Each simply follows a program, step-by-step, producing behavior that makes them appear to understand. However, Searle would not be able to understand the conversation. Therefore, he argues, it follows that the computer would not be able to understand the conversation either. Searle argues that, without "understanding" (or "intentionality"), we cannot describe what the machine is doing as "thinking" and, since it does not think, it does not have a "mind" in the normal sense of the word. Therefore, he concludes that the strong AI hypothesis is false: a computer running a program that simulates a mind would not have a mind in the same sense that human beings have a mind. == History == Gottfried Wilhelm Leibniz made a similar argument in 1713 against mechanism, the idea that everything that makes up a human being could, in principle, be explained in mechanical terms—in other words, that a person, including their mind, is merely a very complex machine. Leibniz used the thought experiment of expanding the brain until it was the size of a mill. He found it difficult to imagine that a "mind" capable of "perception" could be constructed using only mechanical processes. British philosopher Peter Winch made the same point in his 1958 book The Idea of a Social Science and its Relation to Philosophy, in which he argues that "a man who understands Chinese is not a man who has a firm grasp of the statistical probabilities for the occurrence of the various words in the Chinese language" (p. 108). Soviet cyberneticist Anatoly Dneprov made an essentially identical argument in 1961, in the form of his short story "The Game". In it, a stadium of people act as switches and memory cells implementing a program to translate a sentence from Portuguese, a language none of them know. The game was organized by a "Professor Zarubin" to answer the question "Can mathematical machines think?" Speaking through Zarubin, Dneprov writes that "the only way to prove that machines can think is to turn yourself into a machine and examine your thinking process", and he concludes, as Searle does, that "even the most perfect simulation of machine thinking is not the thinking process itself." In 1974, Lawrence H. Davis imagined duplicating the brain using telephone lines and offices staffed by people, and in 1978, Ned Block envisioned the entire population of China involved in such a brain simulation. This is known as the China brain thought experiment. Searle's version appeared in his 1980 article "Minds, Brains, and Programs", published in Behavioral and Brain Sciences. It eventually became the journal's "most influential target article", generating an enormous number of commentaries and responses in the ensuing decades, and Searle had continued to defend and refine the argument in multiple papers, popular articles, and books. David Cole writes that "the Chinese Room argument has probably been the most widely discussed philosophical argument in cognitive science to appear in the past 25 years". Most of the discussion consists of attempts to refute it. "The overwhelming majority", notes Behavioral and Brain Sciences editor Stevan Harnad, "still think that the Chinese Room Argument is dead wrong". The sheer volume of the literature that has grown up around it inspired Pat Hayes to comment that the field of cognitive science ought to be redefined as "the ongoing research program of showing Searle's Chinese Room Argument to be false". Searle's argument has become "something of a classic in cognitive science", according to Harnad. Varol Akman agrees, and has described the original paper as "an exemplar of philosophical clarity and purity". == Philosophy == Although the Chinese Room argument was originally presented in reaction to the statements of artificial intelligence researchers, philosophers have come to consider it as an important part of the philosophy of mind. It is a challenge to functionalism and the computational theory of mind, and is related to such questions as the mind–body problem, the problem of other minds, the symbol grounding problem, and the hard problem of consciousness. === Strong AI === Searle identified a philosophical position he calls "strong AI": The appropriately programmed computer with the right inputs and outputs would thereby have a mind in exactly the same sense human beings have minds. The definition depends on the distinction between simulating a mind and actually having one. Searle writes that "according to Strong AI, the correct simulation really is a mind. According to Weak AI, the correct simulation is a model of the mind." The claim is implicit in some of the statements of early AI researchers and analysts. For example, in 1957, the economist and psychologist Herbert A. Simon declared that "there are now in the world machines that think, that learn and create". Simon, together with Allen Newell and Cliff Shaw, after having completed the first program that could do formal reasoning (the Logic Theorist), claimed that they had "solved the venerable mind–body problem, explaining how a system composed of matter can have the properties of mind." John Haugeland wrote that "AI wants only the genuine article: machines with minds, in the full and literal sense. This is not science fiction, but real science, based on a theoretical conception as deep as it is daring: namely, we are, at root, computers ourselves." Searle also ascribes the following claims to advocates of strong AI: AI systems can be used to explain the mind; The study of the brain is irrelevant to the study of the mind; and The Turing test is adequate for establishing the existence of mental states. === Strong AI as computationalism or functionalism === In more recent presentations of the Chinese room argument, Searle has identified "strong AI" as "computer functionalism" (a term he attributes to Daniel Dennett). Functionalism is a position in modern philosophy of mind that holds that we can define menta
Netvibes
Netvibes is a French brand of Dassault Systèmes that previously ran a web service offering a dashboard and feed reader. Currently, the company offers business intelligence tools. == History == === 2005–2012 === Founded in 2005 by Tariq Krim, the company provided software for personalized dashboards for real-time monitoring, social analytics, knowledge sharing, and decision support. === 2012–present === On February 9, 2012, Dassault Systèmes announced the acquisition of Netvibes. As of 2024, Netvibes also contains the operations of two other software companies acquired by Dassault Systèmes: Exalead: founded in 2000 by François Bourdoncle, the company provided search platforms and search-based applications for consumer and business users. On June 9, 2010, Dassault Systèmes acquired the company. Proxem: Founded in 2007 by François-Régis Caumartin, the company provided AI-powered semantic processing software and services. On June 23, 2020, Dassault Systèmes acquired Proxem and integrated its technology into the 3DEXPERIENCE® platform to complement its information intelligence applications. Dassault Systèmes announced in April 2025 that Netvibes would retire its standalone web service offering on June 2, 2025. == Activities == Brand monitoring – to track clients, customers and competitors across media sources all in one place, analyze live results with third party reporting tools, and provide media monitoring dashboards for brand clients. E-reputation management – to visualize real-time online conversations and social activity online feeds, and track new trending topics. Product marketing – to create interactive product microsites, with drag-and-drop publishing interface. Community portals – to engage online communities Personalized workspaces – to gather all essential company updates to support specific divisions (e.g. sales, marketing, human resources) and localizations. The software was a multi-lingual Ajax-based start page or web portal. It was organized into tabs, with each tab containing user-defined modules. Built-in Netvibes modules included an RSS/Atom feed reader, local weather forecasts, a calendar supporting iCal, bookmarks, notes, to-do lists, multiple searches, support for POP3, IMAP4 email as well as several webmail providers including Gmail, Yahoo! Mail, Hotmail, and AOL Mail, Box.net web storage, Delicious, Meebo, Flickr photos, podcast support with a built-in audio player, and several others. A page could be personalized further through the use of existing themes or by creating personal theme. Customized tabs, feeds and modules can be shared with others individually or via the Netvibes Ecosystem. For privacy reasons, only modules with publicly available content could be shared.
GENESIS (software)
GENESIS (The General Neural Simulation System) is a simulation environment for constructing realistic models of neurobiological systems at many levels of scale including: sub-cellular processes, individual neurons, networks of neurons, and neuronal systems. These simulations are “computer-based implementations of models whose primary objective is to capture what is known of the anatomical structure and physiological characteristics of the neural system of interest”. GENESIS is intended to quantify the physical framework of the nervous system in a way that allows for easy understanding of the physical structure of the nerves in question. “At present only GENESIS allows parallelized modeling of single neurons and networks on multiple-instruction-multiple-data parallel computers.” Development of GENESIS software spread from its home at Caltech to labs at the University of Texas at San Antonio, the University of Antwerp, the National Centre for Biological Sciences in Bangalore, the University of Colorado, the Pittsburgh Supercomputing Center, the San Diego Supercomputer Center, and Emory University. == Neurons and Neural Systems == GENESIS works by creating simulation environments for constructing models of neurons or neural systems. "Nerve cells are capable of communicating with each other in such a highly structured manner as to form neuronal networks. To understand neural networks, it is necessary to understand the ways in which one neuron communicates with another through synaptic connections and the process called synaptic transmission". Neurons have a specialized structure for their function, they "are different from most other cells in the body in that they are polarized and have distinct morphological regions, each with specific functions". The two important regions of a neuron are the dendrite and the axon. "Dendrites are the region where one neuron receives connections from other neurons. The cell body or soma contains the nucleus and the other organelles necessary for cellular function. The axon is a key component of nerve cells over which information is transmitted from one part of the neuron (e.g., the cell body) to the terminal regions of the neuron". The third important piece of a neuron is the synapse. "The synapse is the terminal region of the axon this is where one neuron forms a connection with another and conveys information through the process of synaptic transmission". Neural networks like the ones simulated with GENESIS software can quickly become highly complex and difficult to understand. "Just a few interconnected neurons (a microcircuit) can perform sophisticated tasks such as mediate reflexes, process sensory information, generate locomotion and mediate learning and memory. Even more complex networks, macrocircuits, consist of multiple embedded microcircuits. Macrocircuits mediate higher brain functions such as object recognition and cognition". GENESIS endeavors to simulate neural systems as they are found in nature. Often, "a neuron can receive contacts from up to 10,000 presynaptic neurons, and, in turn, any one neuron can contact up to 10,000 postsynaptic neurons. The combinatorial possibility could give rise to enormously complex neuronal circuits or network topologies, which might be very difficult to understand". == History == GENESIS was developed by Dr. James M. Bower, in the Caltech laboratory, and first released to the public in 1988 in association with the first Methods in Computational Neuroscience Course at the Marine Biological Laboratory in Woods Hole, MA. Full source code for the software was released in the same year under an open software model for development. It's now supported by the Computational Biology Initiative at the University of Texas at San Antonio and is available free along with tutorial guides on its use. P-GENESIS, a parallel version of GENESIS, was first run in 1990 on the Intel Delta, which was the prototype for the Intel Paragon family of massively parallel supercomputers. == How GENESIS Works == GENESIS is useful in creating a simulation environment for constructing models of neurobiological systems, such as: sub-cellular processes individual neurons networks of neurons neuronal systems The GENESIS system is complicated, but relatively easy to use. An individual can input commands through one of three ways: script files, graphical user interface, or the GENESIS command shell. These commands are then processed by the script language interpreter. "The Script Language Interpreter processes commands entered through the keyboard, script files, or the graphical user interface, and passes them to the GENESIS simulation engine. The simulation engine also loads compiled object libraries, reads and writes data files, and interacts with the graphical user interface". Below is a graphical representation of the user input process and a sample GENESIS output. == Applications == Most current applications for GENESIS involve realistic simulations of biological systems. It is usually used to simulate the behavior of larger brain structures, for example the cerebral cortex. These studies most often occur in lab courses in neural simulation at Caltech and the Marine Biological Laboratory at Woods Hole, Massachusetts. GENESIS can be used in combination with Yale University’s software called NEURON as a means for scientists to collaborate to construct a physical description of the nervous system. The GENESIS software can also be used with Kinetikit in the modeling of signal transduction pathways. GENESIS has been used in many studies. Some of these studies involve research that focuses on the development of software that would be useful across many disciplines. Others are studies of neurons, such as Purkinje cells. These studies used GENESIS to simulate Purkinje cells and could be useful for the planning and development of later experiments using the GENESIS software. There may also be biomedical applications of the software. For example, St. Jude Medical in Europe has developed an implanted GENESIS device.