The International Clinical Trials Registry Platform (ICTRP) is a platform for the registration of clinical trials operated by the World Health Organization. The ICTRP combines data from multiple cooperating clinical trials registries to generate a global view of clinical trials worldwide, with a search portal that allows access to the entire dataset. It requires a minimum standard set of database fields, the WHO Trial Registration Data Set, to be present for a trial to be registered. All entries are given a Universal Trial Number (UTN) that identifies them uniquely. The organization has sought to assist various national governments in establishing their own clinical trials databases. It combines data from the following primary registries and data providers: Australian New Zealand Clinical Trials Registry (ANZCTR) Brazilian Clinical Trials Registry (ReBec) Chinese Clinical Trial Registry (ChiCTR) Clinical Research Information Service (CRiS), Republic of Korea ClinicalTrials.gov Clinical Trials Information System (CTIS), European Medicines Agency Clinical Trials Registry - India (CTRI) Cuban Public Registry of Clinical Trials (RPCEC) EU Clinical Trials Register (EU-CTR) German Clinical Trials Register (DRKS) Iranian Registry of Clinical Trials (IRCT) ISRCTN (UK) International Traditional Medicine Clinical Trial Registry (ITMCTR) Japan Registry of Clinical Trials (jRCT) Japan Primary Registries Network (JPRN) Lebanese Clinical Trials Registry (LBCTR) Overview of Medical Research in the Netherlands (OMON) Thai Clinical Trials Registry (TCTR) Pan African Clinical Trial Registry (PACTR) Peruvian Clinical Trial Registry (REPEC) Sri Lanka Clinical Trials Registry (SLCTR)
Aikuma
Aikuma is an Android app for collecting speech recordings with time-aligned translations. The app includes a text-free interface for consecutive interpretation, designed for users who are not literate. The Aikuma won Grand Prize in the Open Source Software World Challenge (2013). == Name == Aikuma means "meeting place" in Usarufa, a Papuan language where this software was first used in 2012. == History == Aikuma was developed with sponsorship from the National Science Foundation, including a $101,501 (US) project, "to use mobile telephones to collect larger amounts of data on undocumented endangered languages than would never be possible through usual fieldwork." Aikuma and its modified version (Lig-Aikuma) have been used for collecting substantial quantities of audio in remote indigenous villages. A modified version of the app, called Lig-Aikuma, has been developed at the Université Grenoble Alpes (LIG laboratory) and implements new features such as elicitation of speech from text, images and videos. == Similar Software == Lingua Libre is an online collaborative project and tool by the Wikimedia France association, which can be used as a tool for Language Preservation. Lingua Libre enables to record words, phrases, or sentences of any language, oral (audio recording) or signed (video recording). It is a highly efficient method to record endangered languages since up to 1000 words can be recorded per hour. All the content is under Free License, and speakers of minority languages are encouraged to record their own dialects.
Photo-consistency
In computer vision, photo-consistency determines whether a given voxel is occupied. A voxel is considered to be photo consistent when its color appears to be similar to all the cameras that can see it. Most voxel coloring or space carving techniques require using photo consistency as a check condition in Image-based modeling and rendering applications. == Usage == 3D Volumetric Reconstruction. Image registration. Multi-view reconstruction.
Shape context
Shape context is a feature descriptor used in object recognition. Serge Belongie and Jitendra Malik proposed the term in their paper "Matching with Shape Contexts" in 2000. == Theory == The shape context is intended to be a way of describing shapes that allows for measuring shape similarity and the recovering of point correspondences. The basic idea is to pick n points on the contours of a shape. For each point pi on the shape, consider the n − 1 vectors obtained by connecting pi to all other points. The set of all these vectors is a rich description of the shape localized at that point but is far too detailed. The key idea is that the distribution over relative positions is a robust, compact, and highly discriminative descriptor. So, for the point pi, the coarse histogram of the relative coordinates of the remaining n − 1 points, h i ( k ) = # { q ≠ p i : ( q − p i ) ∈ bin ( k ) } {\displaystyle h_{i}(k)=\#\{q\neq p_{i}:(q-p_{i})\in {\mbox{bin}}(k)\}} is defined to be the shape context of p i {\displaystyle p_{i}} . The bins are normally taken to be uniform in log-polar space. The fact that the shape context is a rich and discriminative descriptor can be seen in the figure below, in which the shape contexts of two different versions of the letter "A" are shown. (a) and (b) are the sampled edge points of the two shapes. (c) is the diagram of the log-polar bins used to compute the shape context. (d) is the shape context for the point marked with a circle in (a), (e) is that for the point marked as a diamond in (b), and (f) is that for the triangle. As can be seen, since (d) and (e) are the shape contexts for two closely related points, they are quite similar, while the shape context in (f) is very different. For a feature descriptor to be useful, it needs to have certain invariances. In particular it needs to be invariant to translation, scaling, small perturbations, and, depending on the application, rotation. Translational invariance comes naturally to shape context. Scale invariance is obtained by normalizing all radial distances by the mean distance α {\displaystyle \alpha } between all the point pairs in the shape although the median distance can also be used. Shape contexts are empirically demonstrated to be robust to deformations, noise, and outliers using synthetic point set matching experiments. One can provide complete rotational invariance in shape contexts. One way is to measure angles at each point relative to the direction of the tangent at that point (since the points are chosen on edges). This results in a completely rotationally invariant descriptor. But of course this is not always desired since some local features lose their discriminative power if not measured relative to the same frame. Many applications in fact forbid rotational invariance e.g. distinguishing a "6" from a "9". == Use in shape matching == A complete system that uses shape contexts for shape matching consists of the following steps (which will be covered in more detail in the Details of Implementation section): Randomly select a set of points that lie on the edges of a known shape and another set of points on an unknown shape. Compute the shape context of each point found in step 1. Match each point from the known shape to a point on an unknown shape. To minimize the cost of matching, first choose a transformation (e.g. affine, thin plate spline, etc.) that warps the edges of the known shape to the unknown (essentially aligning the two shapes). Then select the point on the unknown shape that most closely corresponds to each warped point on the known shape. Calculate the "shape distance" between each pair of points on the two shapes. Use a weighted sum of the shape context distance, the image appearance distance, and the bending energy (a measure of how much transformation is required to bring the two shapes into alignment). To identify the unknown shape, use a nearest-neighbor classifier to compare its shape distance to shape distances of known objects. == Details of implementation == === Step 1: Finding a list of points on shape edges === The approach assumes that the shape of an object is essentially captured by a finite subset of the points on the internal or external contours on the object. These can be simply obtained using the Canny edge detector and picking a random set of points from the edges. Note that these points need not and in general do not correspond to key-points such as maxima of curvature or inflection points. It is preferable to sample the shape with roughly uniform spacing, though it is not critical. === Step 2: Computing the shape context === This step is described in detail in the Theory section. === Step 3: Computing the cost matrix === Consider two points p and q that have normalized K-bin histograms (i.e. shape contexts) g(k) and h(k). As shape contexts are distributions represented as histograms, it is natural to use the χ2 test statistic as the "shape context cost" of matching the two points: C S = 1 2 ∑ k = 1 K [ g ( k ) − h ( k ) ] 2 g ( k ) + h ( k ) {\displaystyle C_{S}={\frac {1}{2}}\sum _{k=1}^{K}{\frac {[g(k)-h(k)]^{2}}{g(k)+h(k)}}} The values of this range from 0 to 1. In addition to the shape context cost, an extra cost based on the appearance can be added. For instance, it could be a measure of tangent angle dissimilarity (particularly useful in digit recognition): C A = 1 2 ‖ ( cos ( θ 1 ) sin ( θ 1 ) ) − ( cos ( θ 2 ) sin ( θ 2 ) ) ‖ {\displaystyle C_{A}={\frac {1}{2}}{\begin{Vmatrix}{\dbinom {\cos(\theta _{1})}{\sin(\theta _{1})}}-{\dbinom {\cos(\theta _{2})}{\sin(\theta _{2})}}\end{Vmatrix}}} This is half the length of the chord in unit circle between the unit vectors with angles θ 1 {\displaystyle \theta _{1}} and θ 2 {\displaystyle \theta _{2}} . Its values also range from 0 to 1. Now the total cost of matching the two points could be a weighted-sum of the two costs: C = ( 1 − β ) C S + β C A {\displaystyle C=(1-\beta )C_{S}+\beta C_{A}\!\,} Now for each point pi on the first shape and a point qj on the second shape, calculate the cost as described and call it Ci,j. This is the cost matrix. === Step 4: Finding the matching that minimizes total cost === Now, a one-to-one matching π ( i ) {\displaystyle \pi (i)} that matches each point pi on shape 1 and qj on shape 2 that minimizes the total cost of matching, H ( π ) = ∑ i C ( p i , q π ( i ) ) {\displaystyle H(\pi )=\sum _{i}C\left(p_{i},q_{\pi (i)}\right)} is needed. This can be done in O ( N 3 ) {\displaystyle O(N^{3})} time using the Hungarian method, although there are more efficient algorithms. To have robust handling of outliers, one can add "dummy" nodes that have a constant but reasonably large cost of matching to the cost matrix. This would cause the matching algorithm to match outliers to a "dummy" if there is no real match. === Step 5: Modeling transformation === Given the set of correspondences between a finite set of points on the two shapes, a transformation T : R 2 → R 2 {\displaystyle T:\mathbb {R} ^{2}\to \mathbb {R} ^{2}} can be estimated to map any point from one shape to the other. There are several choices for this transformation, described below. ==== Affine ==== The affine model is a standard choice: T ( p ) = A p + o {\displaystyle T(p)=Ap+o\!} . The least squares solution for the matrix A {\displaystyle A} and the translational offset vector o is obtained by: o = 1 n ∑ i = 1 n ( p i − q π ( i ) ) , A = ( Q + P ) t {\displaystyle o={\frac {1}{n}}\sum _{i=1}^{n}\left(p_{i}-q_{\pi (i)}\right),A=(Q^{+}P)^{t}} Where P = ( 1 p 11 p 12 ⋮ ⋮ ⋮ 1 p n 1 p n 2 ) {\displaystyle P={\begin{pmatrix}1&p_{11}&p_{12}\\\vdots &\vdots &\vdots \\1&p_{n1}&p_{n2}\end{pmatrix}}} with a similar expression for Q {\displaystyle Q\!} . Q + {\displaystyle Q^{+}\!} is the pseudoinverse of Q {\displaystyle Q\!} . ==== Thin plate spline ==== The thin plate spline (TPS) model is the most widely used model for transformations when working with shape contexts. A 2D transformation can be separated into two TPS function to model a coordinate transform: T ( x , y ) = ( f x ( x , y ) , f y ( x , y ) ) {\displaystyle T(x,y)=\left(f_{x}(x,y),f_{y}(x,y)\right)} where each of the ƒx and ƒy have the form: f ( x , y ) = a 1 + a x x + a y y + ∑ i = 1 n ω i U ( ‖ ( x i , y i ) − ( x , y ) ‖ ) , {\displaystyle f(x,y)=a_{1}+a_{x}x+a_{y}y+\sum _{i=1}^{n}\omega _{i}U\left({\begin{Vmatrix}(x_{i},y_{i})-(x,y)\end{Vmatrix}}\right),} and the kernel function U ( r ) {\displaystyle U(r)\!} is defined by U ( r ) = r 2 log r 2 {\displaystyle U(r)=r^{2}\log r^{2}\!} . The exact details of how to solve for the parameters can be found elsewhere but it essentially involves solving a linear system of equations. The bending energy (a measure of how much transformation is needed to align the points) will also be easily obtained. ==== Regularized TPS ==== The TPS formulation above has exact matching requirement for the pairs of points on the two shapes. For noisy data, it is best to
Object co-segmentation
In computer vision, object co-segmentation is a special case of image segmentation, which is defined as jointly segmenting semantically similar objects in multiple images or video frames. == Challenges == It is often challenging to extract segmentation masks of a target/object from a noisy collection of images or video frames, which involves object discovery coupled with segmentation. A noisy collection implies that the object/target is present sporadically in a set of images or the object/target disappears intermittently throughout the video of interest. Early methods typically involve mid-level representations such as object proposals. == Dynamic Markov networks-based methods == A joint object discover and co-segmentation method based on coupled dynamic Markov networks has been proposed recently, which claims significant improvements in robustness against irrelevant/noisy video frames. Unlike previous efforts which conveniently assumes the consistent presence of the target objects throughout the input video, this coupled dual dynamic Markov network based algorithm simultaneously carries out both the detection and segmentation tasks with two respective Markov networks jointly updated via belief propagation. Specifically, the Markov network responsible for segmentation is initialized with superpixels and provides information for its Markov counterpart responsible for the object detection task. Conversely, the Markov network responsible for detection builds the object proposal graph with inputs including the spatio-temporal segmentation tubes. == Graph cut-based methods == Graph cut optimization is a popular tool in computer vision, especially in earlier image segmentation applications. As an extension of regular graph cuts, multi-level hypergraph cut is proposed to account for more complex high order correspondences among video groups beyond typical pairwise correlations. With such hypergraph extension, multiple modalities of correspondences, including low-level appearance, saliency, coherent motion and high level features such as object regions, could be seamlessly incorporated in the hyperedge computation. In addition, as a core advantage over co-occurrence based approach, hypergraph implicitly retains more complex correspondences among its vertices, with the hyperedge weights conveniently computed by eigenvalue decomposition of Laplacian matrices. == CNN/LSTM-based methods == In action localization applications, object co-segmentation is also implemented as the segment-tube spatio-temporal detector. Inspired by the recent spatio-temporal action localization efforts with tubelets (sequences of bounding boxes), Le et al. present a new spatio-temporal action localization detector Segment-tube, which consists of sequences of per-frame segmentation masks. This Segment-tube detector can temporally pinpoint the starting/ending frame of each action category in the presence of preceding/subsequent interference actions in untrimmed videos. Simultaneously, the Segment-tube detector produces per-frame segmentation masks instead of bounding boxes, offering superior spatial accuracy to tubelets. This is achieved by alternating iterative optimization between temporal action localization and spatial action segmentation. The proposed segment-tube detector is illustrated in the flowchart on the right. The sample input is an untrimmed video containing all frames in a pair figure skating video, with only a portion of these frames belonging to a relevant category (e.g., the DeathSpirals). Initialized with saliency based image segmentation on individual frames, this method first performs temporal action localization step with a cascaded 3D CNN and LSTM, and pinpoints the starting frame and the ending frame of a target action with a coarse-to-fine strategy. Subsequently, the segment-tube detector refines per-frame spatial segmentation with graph cut by focusing on relevant frames identified by the temporal action localization step. The optimization alternates between the temporal action localization and spatial action segmentation in an iterative manner. Upon practical convergence, the final spatio-temporal action localization results are obtained in the format of a sequence of per-frame segmentation masks (bottom row in the flowchart) with precise starting/ending frames.
Seq2seq
Seq2seq is a family of machine learning approaches used for natural language processing. Originally developed by Lê Viết Quốc, a Vietnamese computer scientist and a machine learning pioneer at Google Brain, this framework has become foundational in many modern AI systems. Applications include language translation, image captioning, conversational models, speech recognition, and text summarization. Seq2seq uses sequence transformation: it turns one sequence into another sequence. == History == One naturally wonders if the problem of translation could conceivably be treated as a problem in cryptography. When I look at an article in Russian, I say: 'This is really written in English, but it has been coded in some strange symbols. I will now proceed to decode. seq2seq is an approach to machine translation (or more generally, sequence transduction) with roots in information theory, where communication is understood as an encode-transmit-decode process, and machine translation can be studied as a special case of communication. This viewpoint was elaborated, for example, in the noisy channel model of machine translation. In practice, seq2seq maps an input sequence into a real-numerical vector by using a neural network (the encoder), and then maps it back to an output sequence using another neural network (the decoder). The idea of encoder-decoder sequence transduction had been developed in the early 2010s. The papers most commonly cited as the originators that produced seq2seq are two papers from 2014. In the seq2seq as proposed by them, both the encoder and the decoder were LSTMs. This had the "bottleneck" problem, since the encoding vector has a fixed size, so for long input sequences, information would tend to be lost, as they are difficult to fit into the fixed-length encoding vector. The attention mechanism, proposed in 2014, resolved the bottleneck problem. They called their model RNNsearch, as it "emulates searching through a source sentence during decoding a translation". A problem with seq2seq models at this point was that recurrent neural networks are difficult to parallelize. The 2017 publication of Transformers resolved the problem by replacing the encoding RNN with self-attention Transformer blocks ("encoder blocks"), and the decoding RNN with cross-attention causally-masked Transformer blocks ("decoder blocks"). === Priority dispute === One of the papers cited as the originator for seq2seq is (Sutskever et al 2014), published at Google Brain while they were on Google's machine translation project. The research allowed Google to overhaul Google Translate into Google Neural Machine Translation in 2016. Tomáš Mikolov claims to have developed the idea (before joining Google Brain) of using a "neural language model on pairs of sentences... and then [generating] translation after seeing the first sentence"—which he equates with seq2seq machine translation, and to have mentioned the idea to Ilya Sutskever and Quoc Le (while at Google Brain), who failed to acknowledge him in their paper. Mikolov had worked on RNNLM (using RNN for language modelling) for his PhD thesis, and is more notable for developing word2vec. == Architecture == The main reference for this section is. === Encoder === The encoder is responsible for processing the input sequence and capturing its essential information, which is stored as the hidden state of the network and, in a model with attention mechanism, a context vector. The context vector is the weighted sum of the input hidden states and is generated for every time instance in the output sequences. === Decoder === The decoder takes the context vector and hidden states from the encoder and generates the final output sequence. The decoder operates in an autoregressive manner, producing one element of the output sequence at a time. At each step, it considers the previously generated elements, the context vector, and the input sequence information to make predictions for the next element in the output sequence. Specifically, in a model with attention mechanism, the context vector and the hidden state are concatenated together to form an attention hidden vector, which is used as an input for the decoder. The seq2seq method developed in the early 2010s uses two neural networks: an encoder network converts an input sentence into numerical vectors, and a decoder network converts those vectors to sentences in the target language. The Attention mechanism was grafted onto this structure in 2014 and is shown below. Later it was refined into the encoder-decoder Transformer architecture of 2017. === Training vs prediction === There is a subtle difference between training and prediction. During training time, both the input and the output sequences are known. During prediction time, only the input sequence is known, and the output sequence must be decoded by the network itself. Specifically, consider an input sequence x 1 : n {\displaystyle x_{1:n}} and output sequence y 1 : m {\displaystyle y_{1:m}} . The encoder would process the input x 1 : n {\displaystyle x_{1:n}} step by step. After that, the decoder would take the output from the encoder, as well as the
Brave Leo
Brave Leo is a large language model-based chatbot developed by Brave Software and included with the Brave browser. == History == In November 2023, the company said versions for iOS and Android would be available "in the coming months". == Features == Since January 2024, Leo has used the open-source Mixtral 8x7B from Mistral AI as its default large language model, in addition to LLaMA 2 from Meta Platforms and Claude from Anthropic, both of which have been used previously. Leo can suggest follow-up questions, and summarize webpages, PDFs, and videos. Leo has a $15 (US) per month premium version that enables more requests and uses larger LLMs. == Privacy == The answers given by Leo are not saved. Brave uses the slogan Love Privacy to emphasize its focus on user privacy and data protection. The phrase has been featured in Brave's official marketing campaigns and has been cited in media coverage of the browser's privacy-first approach. == Controversies == In 2023, PC World reported that Leo evades questions about US elections.