Tute Genomics was an American genomics startup that provided a cloud-based web application for rapid and accurate annotation of human genomic data. It was built on the expertise of ANNOVAR. Tute Genomics assisted researchers in identifying disease genes and biomarkers, and assisted clinicians/labs in performing genetic diagnosis. Based in Provo, Utah, Tute was co-founded by Dr. Kai Wang, an assistant professor at the University of Southern California (USC); and Dr. Reid J. Robison, a board-certified psychiatrist with fellowship training in both neurodevelopmental genetics and bioinformatics. Tute Genomics was acquired by PierianDX in 2016. == History == The word "tute" means "personal" in the Na’vi language created for the 2009 film Avatar by Paul Frommer, a linguist and communications professor at the USC Marshall School of Business. === Timeline === 2013 Tute Genomics launched in 2013 and entered the accelerator, BoomStartup. By "demo day" of BoomStartup, Tute had raised their seed round of funding and expanded the round to include angel investors from SLC Angels, Park City Angels, Life Science Angels. Tute was the tenth ever online syndicate for AngelList and in all raised a seed round of $1.5 million. 2014 In March 2014, the company announced that Affiliated Genetics, a Utah-based CLIA-certified laboratory, selected Tute Genomics for its next-generation sequencing (NGS) analytics pipeline. In May 2014, the company announced joining the Global Alliance for Genomics and Health. In June 2014, Advanced Biological Laboratories (ABL), S.A., announced a licensing and collaboration agreement with Tute Genomics and the commercial launch of OncoChek for managing and analysing genomics data in the field of oncology. In July 2014, the company announced an agreement with Lineagen, Inc., to provide next-generation sequencing analytics for Lineagen’s NextStepDx Plus assay. Also, Brigham Young University selected the Tute Genomics genome annotation and discovery platform for analysis and interpretation of 1,000 exomes and genomes. In November 2014, the company announced addition of the Tute platform to Illumina’s BaseSpace. The company announced a Series A1 funding round of $2.3 million in December 2014. The round was led by UK-based Eurovestech. Peak Ventures and a number of angel investors also participated in this round. 2015 Tute recruits David Mittelman, founder of Arpeggi, Inc. and former CSO at FamilyTreeDNA, to Tute Genomics as Chief Scientific Officer. Tute acquires Knome and integrates the KnoSys platform into its software product. 2016 Reid Robison, Tute CEO, launches a Kickstarter campaign to sell Tute interpreted whole genome and whole exome sequencing directly to consumers. The campaign was suspended within the same month after receiving a letter from the United States Food and Drug Administration. Tute is acquired by PierianDX.
LCD crosstalk
LCD crosstalk is a visual defect in an LCD screen which occurs because of interference between adjacent pixels. Owing to the way rows and columns in the display are addressed, and charge is pushed around, the data on one part of the display has the potential to influence what is displayed elsewhere. This is generally known as crosstalk, and in matrix displays typically occurs in the horizontal and vertical directions. Crosstalk used to be a serious problem in the old passive-matrix (STN) displays, but is rarely discernable in modern active-matrix (TFT) displays. A fortunate side effect of inversion (see above) is that, for most display material, what little crosstalk there is largely cancelled out. For most practical purposes, the level of crosstalk in modern LCDs is negligible. Certain patterns, particularly those involving fine dots, can interact with the inversion and reveal visible crosstalk. If you try moving a small Window in front of the inversion pattern (above) which makes your screen flicker the most, you may well see crosstalk in the surrounding pattern. Different patterns are required to reveal crosstalk on different displays (depending on their inversion scheme).
International Conference on Acoustics, Speech, and Signal Processing
ICASSP, the International Conference on Acoustics, Speech, and Signal Processing, is an annual flagship conference organized by IEEE Signal Processing Society. Ei Compendex has indexed all papers included in its proceedings. The first ICASSP was held in 1976 in Philadelphia, Pennsylvania, based on the success of a conference in Massachusetts four years earlier that had focused specifically on speech signals. As ranked by Google Scholar's h-index metric in 2016, ICASSP has the highest h-index of any conference in the Signal Processing field. The Brazilian ministry of education gave the conference an 'A1' rating based on its h-index. == Conference list ==
Diffusion map
Diffusion maps is a dimensionality reduction or feature extraction algorithm introduced by Coifman and Lafon which computes a family of embeddings of a data set into Euclidean space (often low-dimensional) whose coordinates can be computed from the eigenvectors and eigenvalues of a diffusion operator on the data. The Euclidean distance between points in the embedded space is equal to the "diffusion distance" between probability distributions centered at those points. Different from linear dimensionality reduction methods such as principal component analysis (PCA), diffusion maps are part of the family of nonlinear dimensionality reduction methods which focus on discovering the underlying manifold that the data has been sampled from. By integrating local similarities at different scales, diffusion maps give a global description of the data-set. Compared with other methods, the diffusion map algorithm is robust to noise perturbation and computationally inexpensive. == Definition of diffusion maps == Following and , diffusion maps can be defined in four steps. === Connectivity === Diffusion maps exploit the relationship between heat diffusion and random walk Markov chain. The basic observation is that if we take a random walk on the data, walking to a nearby data-point is more likely than walking to another that is far away. Let ( X , A , μ ) {\displaystyle (X,{\mathcal {A}},\mu )} be a measure space, where X {\displaystyle X} is the data set and μ {\displaystyle \mu } represents the distribution of the points on X {\displaystyle X} . Based on this, the connectivity k {\displaystyle k} between two data points, x {\displaystyle x} and y {\displaystyle y} , can be defined as the probability of walking from x {\displaystyle x} to y {\displaystyle y} in one step of the random walk. Usually, this probability is specified in terms of a kernel function of the two points: k : X × X → R {\displaystyle k:X\times X\rightarrow \mathbb {R} } . For example, the popular Gaussian kernel: k ( x , y ) = exp ( − | | x − y | | 2 ϵ ) {\displaystyle k(x,y)=\exp \left(-{\frac {||x-y||^{2}}{\epsilon }}\right)} More generally, the kernel function has the following properties k ( x , y ) = k ( y , x ) {\displaystyle k(x,y)=k(y,x)} ( k {\displaystyle k} is symmetric) k ( x , y ) ≥ 0 ∀ x , y {\displaystyle k(x,y)\geq 0\,\,\forall x,y} ( k {\displaystyle k} is positivity preserving). The kernel constitutes the prior definition of the local geometry of the data-set. Since a given kernel will capture a specific feature of the data set, its choice should be guided by the application that one has in mind. This is a major difference with methods such as principal component analysis, where correlations between all data points are taken into account at once. Given ( X , k ) {\displaystyle (X,k)} , we can then construct a reversible discrete-time Markov chain on X {\displaystyle X} (a process known as the normalized graph Laplacian construction): d ( x ) = ∫ X k ( x , y ) d μ ( y ) {\displaystyle d(x)=\int _{X}k(x,y)d\mu (y)} and define: p ( x , y ) = k ( x , y ) d ( x ) {\displaystyle p(x,y)={\frac {k(x,y)}{d(x)}}} Although the new normalized kernel does not inherit the symmetric property, it does inherit the positivity-preserving property and gains a conservation property: ∫ X p ( x , y ) d μ ( y ) = 1 {\displaystyle \int _{X}p(x,y)d\mu (y)=1} === Diffusion process === From p ( x , y ) {\displaystyle p(x,y)} we can construct a transition matrix of a Markov chain ( M {\displaystyle M} ) on X {\displaystyle X} . In other words, p ( x , y ) {\displaystyle p(x,y)} represents the one-step transition probability from x {\displaystyle x} to y {\displaystyle y} , and M t {\displaystyle M^{t}} gives the t-step transition matrix. We define the diffusion matrix L {\displaystyle L} (it is also a version of graph Laplacian matrix) L i , j = k ( x i , x j ) {\displaystyle L_{i,j}=k(x_{i},x_{j})\,} We then define the new kernel L i , j ( α ) = k ( α ) ( x i , x j ) = L i , j ( d ( x i ) d ( x j ) ) α {\displaystyle L_{i,j}^{(\alpha )}=k^{(\alpha )}(x_{i},x_{j})={\frac {L_{i,j}}{(d(x_{i})d(x_{j}))^{\alpha }}}\,} or equivalently, L ( α ) = D − α L D − α {\displaystyle L^{(\alpha )}=D^{-\alpha }LD^{-\alpha }\,} where D is a diagonal matrix and D i , i = ∑ j L i , j . {\displaystyle D_{i,i}=\sum _{j}L_{i,j}.} We apply the graph Laplacian normalization to this new kernel: M = ( D ( α ) ) − 1 L ( α ) , {\displaystyle M=({D}^{(\alpha )})^{-1}L^{(\alpha )},\,} where D ( α ) {\displaystyle D^{(\alpha )}} is a diagonal matrix and D i , i ( α ) = ∑ j L i , j ( α ) . {\displaystyle {D}_{i,i}^{(\alpha )}=\sum _{j}L_{i,j}^{(\alpha )}.} p ( x j , t | x i ) = M i , j t {\displaystyle p(x_{j},t|x_{i})=M_{i,j}^{t}\,} One of the main ideas of the diffusion framework is that running the chain forward in time (taking larger and larger powers of M {\displaystyle M} ) reveals the geometric structure of X {\displaystyle X} at larger and larger scales (the diffusion process). Specifically, the notion of a cluster in the data set is quantified as a region in which the probability of escaping this region is low (within a certain time t). Therefore, t not only serves as a time parameter, but it also has the dual role of scale parameter. The eigendecomposition of the matrix M t {\displaystyle M^{t}} yields M i , j t = ∑ l λ l t ψ l ( x i ) ϕ l ( x j ) {\displaystyle M_{i,j}^{t}=\sum _{l}\lambda _{l}^{t}\psi _{l}(x_{i})\phi _{l}(x_{j})\,} where { λ l } {\displaystyle \{\lambda _{l}\}} is the sequence of eigenvalues of M {\displaystyle M} and { ψ l } {\displaystyle \{\psi _{l}\}} and { ϕ l } {\displaystyle \{\phi _{l}\}} are the biorthogonal left and right eigenvectors respectively. Due to the spectrum decay of the eigenvalues, only a few terms are necessary to achieve a given relative accuracy in this sum. ==== Parameter α and the diffusion operator ==== The reason to introduce the normalization step involving α {\displaystyle \alpha } is to tune the influence of the data point density on the infinitesimal transition of the diffusion. In some applications, the sampling of the data is generally not related to the geometry of the manifold we are interested in describing. In this case, we can set α = 1 {\displaystyle \alpha =1} and the diffusion operator approximates the Laplace–Beltrami operator. We then recover the Riemannian geometry of the data set regardless of the distribution of the points. To describe the long-term behavior of the point distribution of a system of stochastic differential equations, we can use α = 0.5 {\displaystyle \alpha =0.5} and the resulting Markov chain approximates the Fokker–Planck diffusion. With α = 0 {\displaystyle \alpha =0} , it reduces to the classical graph Laplacian normalization. === Diffusion distance === The diffusion distance at time t {\displaystyle t} between two points can be measured as the similarity of two points in the observation space with the connectivity between them. It is given by D t ( x i , x j ) 2 = ∑ y ( p ( y , t | x i ) − p ( y , t | x j ) ) 2 ϕ 0 ( y ) {\displaystyle D_{t}(x_{i},x_{j})^{2}=\sum _{y}{\frac {(p(y,t|x_{i})-p(y,t|x_{j}))^{2}}{\phi _{0}(y)}}} where ϕ 0 ( y ) {\displaystyle \phi _{0}(y)} is the stationary distribution of the Markov chain, given by the first left eigenvector of M {\displaystyle M} . Explicitly: ϕ 0 ( y ) = d ( y ) ∑ z ∈ X d ( z ) {\displaystyle \phi _{0}(y)={\frac {d(y)}{\sum _{z\in X}d(z)}}} Intuitively, D t ( x i , x j ) {\displaystyle D_{t}(x_{i},x_{j})} is small if there is a large number of short paths connecting x i {\displaystyle x_{i}} and x j {\displaystyle x_{j}} . There are several interesting features associated with the diffusion distance, based on our previous discussion that t {\displaystyle t} also serves as a scale parameter: Points are closer at a given scale (as specified by D t ( x i , x j ) {\displaystyle D_{t}(x_{i},x_{j})} ) if they are highly connected in the graph, therefore emphasizing the concept of a cluster. This distance is robust to noise, since the distance between two points depends on all possible paths of length t {\displaystyle t} between the points. From a machine learning point of view, the distance takes into account all evidences linking x i {\displaystyle x_{i}} to x j {\displaystyle x_{j}} , allowing us to conclude that this distance is appropriate for the design of inference algorithms based on the majority of preponderance. === Diffusion process and low-dimensional embedding === The diffusion distance can be calculated using the eigenvectors by D t ( x i , x j ) 2 = ∑ l λ l 2 t ( ψ l ( x i ) − ψ l ( x j ) ) 2 {\displaystyle D_{t}(x_{i},x_{j})^{2}=\sum _{l}\lambda _{l}^{2t}(\psi _{l}(x_{i})-\psi _{l}(x_{j}))^{2}\,} So the eigenvectors can be used as a new set of coordinates for the data. The diffusion map is defined as: Ψ t ( x ) = ( λ 1 t ψ 1 ( x ) , λ 2 t ψ 2 ( x ) , … , λ k t ψ k ( x ) ) {\displaystyle \Psi _{t}(x)=(\lambda _{1}^{t}\psi _{1}(x),\lambda _{2}^{t}\psi _{2}(x),\ld
Latent class model
In statistics, a latent class model (LCM) is a model for clustering multivariate discrete data. It assumes that the data arise from a mixture of discrete distributions, within each of which the variables are independent. It is called a latent class model because the class to which each data point belongs is unobserved (or latent). Latent class analysis (LCA) is a subset of structural equation modeling used to find groups or subtypes of cases in multivariate categorical data. These groups or subtypes of cases are called "latent classes". When faced with the following situation, a researcher might opt to use LCA to better understand the data: Symptoms a, b, c, and d have been recorded in a variety of patients diagnosed with diseases X, Y, and Z. Disease X is associated with symptoms a, b, and c; disease Y is linked to symptoms b, c, and d; and disease Z is connected to symptoms a, c, and d. In this context, the LCA would attempt to detect the presence of latent classes (i.e., the disease entities), thus creating patterns of association in the symptoms. As in factor analysis, LCA can also be used to classify cases according to their maximum likelihood class membership probability. The key criterion for resolving the LCA is identifying latent classes in which the observed symptom associations are effectively rendered null. This is because within each class, the diseases responsible for the symptoms create a structure of dependencies. As a result, the symptoms become conditionally independent, meaning that, given the class a case belongs to, the symptoms are no longer related to one another. == Model == Within each latent class, the observed variables are statistically independent—an essential aspect of latent class modeling. Usually, the observed variables are statistically dependent. By introducing the latent variable, independence is restored in the sense that within classes, variables are independent (local independence). Therefore, the association between the observed variables is explained by the classes of the latent variable (McCutcheon, 1987). In one form, the LCM is written as p i 1 , i 2 , … , i N ≈ ∑ t T p t ∏ n N p i n , t n , {\displaystyle p_{i_{1},i_{2},\ldots ,i_{N}}\approx \sum _{t}^{T}p_{t}\,\prod _{n}^{N}p_{i_{n},t}^{n},} where T {\displaystyle T} is the number of latent classes and p t {\displaystyle p_{t}} are the so-called recruitment or unconditional probabilities that should sum to one. p i n , t n {\displaystyle p_{i_{n},t}^{n}} are the marginal or conditional probabilities. For a two-way latent class model, the form is p i j ≈ ∑ t T p t p i t p j t . {\displaystyle p_{ij}\approx \sum _{t}^{T}p_{t}\,p_{it}\,p_{jt}.} This two-way model is related to probabilistic latent semantic analysis and non-negative matrix factorization. The probability model used in LCA is closely related to the Naive Bayes classifier. The main difference is that in LCA, the class membership of an individual is a latent variable, whereas in Naive Bayes classifiers, the class membership is an observed label. == Related methods == There are a number of methods with distinct names and uses that share a common relationship. Cluster analysis is, like LCA, used to discover taxon-like groups of cases in data. Multivariate mixture estimation (MME) is applicable to continuous data and assumes that such data arise from a mixture of distributions, such as a set of heights arising from a mixture of men and women. If a multivariate mixture estimation is constrained so that measures must be uncorrelated within each distribution, it is termed latent profile analysis. Modified to handle discrete data, this constrained analysis is known as LCA. Discrete latent trait models further constrain the classes to form from segments of a single dimension, allocating members to classes based on that dimension. An example would be assigning cases to social classes based on ability or merit. In a practical instance, the variables could be multiple choice items of a political questionnaire. In this case, the data consists of an N-way contingency table with answers to the items for a number of respondents. In this example, the latent variable refers to political opinion, and the latent classes to political groups. Given group membership, the conditional probabilities specify the chance that certain answers are chosen. == Application == LCA may be used in many fields, such as: collaborative filtering, Behavior Genetics and Evaluation of diagnostic tests.
Attensity
Attensity was an American company that provided social analytics and engagement applications for social customer relationship management (social CRM). Attensity's text analytics software applications extracted facts, relationships and sentiment from unstructured data. == History == Attensity was founded in 2000. An early investor in Attensity was In-Q-Tel, which funds technology to support the missions of the US Government and the broader DOD. InTTENSITY, an independent company that has combined Inxight with Attensity Software (the only joint development project that combines two InQTel funded software packages), was the exclusive distributor and outlet for Attensity in the Federal Market. In 2009, Attensity Corp., then based in Palo Alto, merged with Germany's Empolis and Living-e AG to form Attensity Group. In 2010, Attensity Group acquired Biz360, a provider of social media monitoring and market intelligence solutions. In early 2012, Attensity Group divested itself of the Empolis business unit via a management buyout; that unit currently conducts business under its pre-merger name. Attensity Group was a closely held private company. Its majority shareholder was Aeris Capital, a private Swiss investment office advising a high-net-worth individual and his charitable foundation. Foundation Capital, Granite Ventures, and Scale Venture Partners were among Biz360's investors and thus became shareholders in Attensity Group. In February 2016, Attensity's IP assets were acquired by InContact, and Attensity closed.
Apache Giraph
Apache Giraph is an Apache project to perform graph processing on big data. Giraph utilizes Apache Hadoop's MapReduce implementation to process graphs. Facebook used Giraph with some performance improvements to analyze one trillion edges using 200 machines in 4 minutes. Giraph is based on a paper published by Google about its own graph processing system called Pregel. It can be compared to other Big Graph processing libraries such as Cassovary. As of September 2023, it is no longer actively developed.