Eimear E. Kenny is a researcher in population genetics and translation genomics, and is the Founding Director of the Institute for Genomic Health, and Endowed Chair and Professor of Genomic Health at the Icahn School of Medicine at Mount Sinai. She is known for novel approaches in computational genomics, advancing the study of human genetic variation and its connection to disease risk and diagnosis. Her research has laid the foundation for integrating artificial intelligence (AI) and genomics into precision medicine and routine clinical care. By combining genomics, computer science, and medicine, her work leverages genomic sequencing technologies and machine learning algorithms to uncover insights that improve patient care, accelerate genomic data analysis, and enable the future of AI-driven healthcare. She has led multiple genomics-based clinical trials, applying computational biology and AI in clinical settings to advance genomic medicine and precision healthcare. == Research == A recipient of the Early-Career Award from the American Society of Human Genetics (USA), Kenny, as of 2024, leads a team in genetics, computer science, and medicine, focusing on genetic ancestry, large-scale genomics, clinical trials, and genomic medicine at the Institute for Genomic Health. The lab works to advance understanding of genetic ancestry and its impact on health in order to inform better clinical medicine models. She is recognized for her work to leverage biobanks for translational genomics and her development of new genetic tests an strategies for health care management. In one study, she and her colleagues investigated genetic disorders that might be under-diagnosed due to insufficient data, and found a variant in a collagen gene associated with Steel syndrome. This syndrome caused short stature and bone and joint issues and was thought to be rare. However, the study revealed it is common in individuals with Puerto Rican ancestry. Three of Kenny's genomic medicine clinical trials assessed how to bring new technology, such as digital apps, or information, such as polygenic risk scores, into routine clinical care. In the 2010s, Kenny was instrumental in several large-scale sequencing studies, including the 1000 Genomes Project, the Exome Sequencing Project, the Genome Sequencing Project, and the Trans-Omics for Precision Medicine. In 2012, she led work that discovered the variant responsible for blond hair in Melanesia, work that was featured in the Smithsonian NHGRI Human Genome Exhibit in Washington, D.C. In 2017, her group was one of the first to demonstrate that polygenic risk scores derived in predominantly European populations have reduced accuracy when applied in populations now widely acknowledged as a major challenge in the field of genomic risk prediction. As of 2024, she is Principal Investigator in many NIH-funded international consortium focused on computational genomics and genomic medicine, including Electronic Medical Records and Genomics, Polygenic Risk Methods in Diverse Populations, and the Human Pangenome Reference Consortium. In 2023, Kenny played a key role in a groundbreaking advancement in genomics research by helping to map a diverse human pangenome—a major shift from reliance on a single reference genome. Unlike the earlier genetic map, based on one man of mixed European and African ancestry in Buffalo, this new pangenome project captures far greater human genetic diversity. As reported by The Washington Post, Kenny's work demonstrates how a more inclusive human genome can drive discoveries in rare genetic diseases, improve genomic medicine, and accelerate the future of precision healthcare. Kenny was co-developer and current license holder for Random Forest adMIXture (RFMix), a patented software for inferring continental and sub-continental ancestry at genomic loci. == Education and career == Kenny graduated from Trinity College Dublin with a BA in Biochemistry in 1999 and did a masters in Bioinformatics at Leeds University. She received her PhD in Computational Genomics at Rockefeller University, and did her post-doctoral work in the lab of Dr. Carlos D. Bustamante at Stanford University. === Academic appointments === As of 2024, at Mount Sinai, she serves as the Endowed Chair and Professor of Genomic Health, Professor at the Department of Medicine and Professor at the Department of Genetics and Genomic Sciences. Since 2018 she has served as the Founding Director of the Institute for Genomic Health, and since 2022, she also serves as the Founding Director of the Center for Translational Genomics. She is also the Director of Translational Research, Division for Genomic Medicine. Former appointments include Assistant Professor at the Department of Genetics and Genomic Sciences and Member at The Charles Bronfman Institute of Personalized Medicine, both at Mount Sinai. She was also Bioinformatics Programmer at the California Institute of Technology, and research assistant at the Massachusetts Institute of Technology. == Publications == As of 2024, Kenny is an advisor to Cell Genomics. Google Scholar reports 50,623 citations, an h-index of 66 and an i10-index of 130. The five most-cited articles she contributed to are: Auton, A; Brooks, LD; Durbin, RM; Garrison, EP; Kang, HM; Korbel, JO; Marchini, JL; McCarthy, S; McVean, GA; Abecasis, GR (2015). "A global reference for human genetic variation". Nature. 526 (7571): 68–74. Bibcode:2015Natur.526...68T. doi:10.1038/nature15393. PMC 4750478. PMID 26432245.. Cited by 14847 Abecasis, GR; Auton, A; Brooks, LD; DePristo, MA; Durbin, RM; Handsaker, RE; Kang, HM; Marth, GT; McVean, GA (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. PMC 3498066. PMID 23128226.. Cited by 8287 Jacob A. Tennessen et al. Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.Science337,64–69(2012).DOI:10.1126/science.1219240 Cited by 1886 Taliun, D.; Harris, D.N.; Kessler, M.D.; et al. (2021). "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program". Nature. 590 (7845): 290–299. Bibcode:2021Natur.590..290T. doi:10.1038/s41586-021-03205-y. PMC 7875770. PMID 33568819.. Cited by 1369 Vilhjálmsson, BJ; et al. (2015). "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores". Am J Hum Genet. 97 (4): 576–92. doi:10.1016/j.ajhg.2015.09.001. PMC 4596916. PMID 26430803.. Cited by 1327
CatDV
CatDV is a media asset manager program for handling multimedia production workflows developed by Square Box Systems. Quantum Corporation acquired Square Box Systems in 2020. == Versions == The full family of CatDV Products is as follows: CatDV Standalone Products CatDV Professional Edition CatDV Pegasus CatDV Networked Products CatDV Essential - entry level server product CatDV Enterprise Server - for MySQL databases and most common server platforms including Linux, Windows and Mac OS X CatDV Pegasus Server - adds features such as high performance full-text indexing, access control lists, and more CatDV Worker Node - automated workflow and transcoding engine CatDV Web Client - provides access to the CatDV database via a web browser. There is no need to install special software on the desktop, making it easy to deploy to a large number of users. CatDV Professional Edition & Pegasus Clients - designed to support the multi-user capabilities of the CatDV Enterprise and Workgroup Servers from the desktop Using plugins and scripting, which often require additional professional services support to set up, complex integrations with a wide variety of third party systems (including archive, cloud storage, and artificial intelligence) are possible. == Awards == CatDV won two awards in 2010, a blue ribbon from Creative COW Magazine and a "Best of Show Vidy Award" from Videography. In April 2012 Square Box won a Queen's Award for Enterprise for CatDV.
Semi-Automatic Ground Environment
The Semi-Automated Ground Environment (SAGE) was a system of large computers and associated networking equipment that coordinated data from many radar sites and processed it to produce a single unified image of the airspace over a wide area. SAGE directed and controlled the NORAD response to a possible Soviet air attack, operating in this role from the late 1950s into the 1980s. The processing power behind SAGE was supplied by the largest discrete component-based computer ever built, the AN/FSQ-7, manufactured by IBM. Each SAGE Direction Center (DC) housed an FSQ-7 which occupied an entire floor, approximately 22,000 square feet (2,000 m2) not including supporting equipment. The FSQ-7 was actually two computers, "A" side and "B" side. Computer processing was switched from "A" side to "B" side on a regular basis, allowing maintenance on the unused side. Information was fed to the DCs from a network of radar stations as well as readiness information from various defense sites. The computers, based on the raw radar data, developed "tracks" for the reported targets, and automatically calculated which defenses were within range. Operators used light guns to select targets on-screen for further information, select one of the available defenses, and issue commands to attack. These commands would then be automatically sent to the defense site via teleprinter. Connecting the various sites was an enormous network of telephones, modems and teleprinters. Later additions to the system allowed SAGE's tracking data to be sent directly to CIM-10 Bomarc missiles and some of the US Air Force's interceptor aircraft in-flight, directly updating their autopilots to maintain an intercept course without operator intervention. Each DC also forwarded data to a Combat Center (CC) for "supervision of the several sectors within the division" ("each combat center [had] the capability to coordinate defense for the whole nation"). SAGE became operational in the late 1950s and early 1960s at an estimated total cost between 8 and 12 billion dollars, four times the cost of the Manhattan Project. Throughout its development, there were continual concerns about its real ability to deal with large attacks, and the Operation Sky Shield tests showed that only about one-fourth of enemy bombers would have been intercepted. Nevertheless, SAGE was the backbone of NORAD's air defense system into the 1980s, by which time the tube-based FSQ-7s were increasingly costly to maintain and completely outdated. Today the same command and control task is carried out by microcomputers, based on the same basic underlying data. == Background == === Earlier systems === Just prior to World War II, Royal Air Force (RAF) tests with the new Chain Home (CH) radars had demonstrated that relaying information to the fighter aircraft directly from the radar sites was not feasible. The radars determined the map coordinates of the enemy, but could generally not see the fighters at the same time. This meant the fighters had to be able to determine where to fly to perform an interception but were often unaware of their own exact location and unable to calculate an interception while also flying their aircraft. The solution was to send all of the radar information to a central control station where operators collated the reports into single tracks, and then reported these tracks to the airbases, or sectors. The sectors used additional systems to track their own aircraft, plotting both on a single large map. Operators viewing the map could then see what direction their fighters would have to fly to approach their targets and relay that simply by telling them to fly along a certain heading or vector. This Dowding system was the first ground-controlled interception (GCI) system of large scale, covering the entirety of the UK. It proved enormously successful during the Battle of Britain, and is credited as being a key part of the RAF's success. The system was slow, often providing information that was up to five minutes out of date. Against propeller driven bombers flying at perhaps 225 miles per hour (362 km/h) this was not a serious concern, but it was clear the system would be of little use against jet-powered bombers flying at perhaps 600 miles per hour (970 km/h). The system was extremely expensive in manpower terms, requiring hundreds of telephone operators, plotters and trackers in addition to the radar operators. This was a serious drain on manpower, making it difficult to expand the network. The idea of using a computer to handle the task of taking reports and developing tracks had been explored beginning late in the war. By 1944, analog computers had been installed at the CH stations to automatically convert radar readings into map locations, eliminating two people. Meanwhile, the Royal Navy began experimenting with the Comprehensive Display System (CDS), another analog computer that took X and Y locations from a map and automatically generated tracks from repeated inputs. Similar systems began development with the Royal Canadian Navy, DATAR, and the US Navy, the Naval Tactical Data System (NTDS). A similar system was also specified for the Nike SAM project, specifically referring to a US version of CDS, coordinating the defense over a battle area so that multiple batteries did not fire on a single target. All of these systems were relatively small in geographic scale, generally tracking within a city-sized area. === Valley Committee === When the Soviet Union tested its first atomic bomb in August 1949, the topic of air defense of the US became important for the first time. A study group, the "Air Defense Systems Engineering Committee", was set up under the direction of Dr. George Valley to consider the problem and is known to history as the "Valley Committee". Their December report noted a key problem in air defense using ground-based radars. A bomber approaching a radar station would detect the signals from the radar long before the reflection off the bomber was strong enough to be detected by the station. The committee suggested that when this occurred, the bomber would descend to low altitude, thereby greatly limiting the radar horizon, allowing the bomber to fly past the station undetected. Although flying at low altitude greatly increased fuel consumption, the team calculated that the bomber would only need to do this for about 10% of its flight, making the fuel penalty acceptable. The only solution to this problem was to build a huge number of stations with overlapping coverage. At that point the problem became one of managing the information. Manual plotting was ruled out as too slow, and a computerized solution was the only possibility. To handle this task, the computer would need to be fed information directly, eliminating any manual translation by phone operators, and it would have to be able to analyze that information and automatically develop tracks. A system tasked with defending cities against the predicted future Soviet bomber fleet would have to be dramatically more powerful than the models used in the NTDS or DATAR. The Committee then had to consider whether or not such a computer was possible. The Valley Committee was introduced to Jerome Wiesner, associate director of the Research Laboratory of Electronics at MIT. Wiesner noted that the Servomechanisms Laboratory had already begun development of a machine that might be fast enough. This was the Whirlwind I, originally developed for the Office of Naval Research as a general purpose flight simulator that could simulate any current or future aircraft by changing its software. Wiesner introduced the Valley Committee to Whirlwind's project lead, Jay Forrester, who convinced him that Whirlwind was sufficiently capable. In September 1950, an early microwave early-warning radar system at Hanscom Field was connected to Whirlwind using a custom interface developed by Forrester's team. An aircraft was flown past the site, and the system digitized the radar information and successfully sent it to Whirlwind. With this demonstration, the technical concept was proven. Forrester was invited to join the committee. === Project Charles === With this successful demonstration, Louis Ridenour, chief scientist of the Air Force, wrote a memo stating "It is now apparent that the experimental work necessary to develop, test, and evaluate the systems proposals made by ADSEC will require a substantial amount of laboratory and field effort." Ridenour approached MIT President James Killian with the aim of beginning a development lab similar to the war-era Radiation Laboratory that made enormous progress in radar technology. Killian was initially uninterested, desiring to return the school to its peacetime civilian charter. Ridenour eventually convinced Killian the idea was sound by describing the way the lab would lead to the development of a local electronics industry based on the needs of the lab and the students who would leave the lab to start their
Instapoetry
Instapoetry is a style of poetry that emerged after the advent of social media, especially on Instagram. The term has been used to describe poems written specifically for being shared online, most commonly on Instagram, but also other platforms including Twitter, Tumblr, and TikTok. The style usually consists of short, direct lines in aesthetically pleasing fonts that are sometimes accompanied by an image or drawing, often without rhyme schemes or meter, and dealing with commonplace themes. Literary critics, poets, and writers have contended with Instapoetry's focus on brevity and plainness compared to traditional poetry, criticizing it for reproducing rather than subverting normative ideas on social media platforms that favor popularity and accessibility over craft and depth. == History == Instapoetry developed as a result of young, predominantly women, amateur poets sharing their output to expand their readership, who began using social media as their preferred method of distribution rather than traditional publishing methods. The term "Instapoetry" is a portmanteau of the words "Instagram" and "poetry," and was created by other writers trying to define and understand the new extension of "instant poetry" shared via social media, most prominently Instagram. In its most basic form, Instapoetry usually consists of bite-sized verses that consider political and social subjects such as immigration, domestic violence, sexual assault, love, culture, feminism, gun violence, war, racism, LGBTQ rights, and other social justice topics. All of these elements are usually made to fit social media feeds that are easily accessible through applications on smartphones. == Scholarship == Despite the diversity of poetry on Instagram, the Brazilian linguist Bruna Osaki Fazano found that shared "aspects of the compositional form, theme and style" mean that it can be understood as a specific genre. Camilla Holm Soelseth argues that taking on the platform-specific tasks of a social media creator is a prerequisite for being an Instapoet. Writing in Poetics Today, JuEunhae Knox combined quantitative and qualitative analysis to show that Instapoetry is a cohesive genre, in part because "the sheer volume and rapidity of content production in turn encourages posts that are not only visually appealing but also immediately recognizable as Instapoems". Instapoetry has been seen as a practice that serves as a form of self-staging for poets and "[crafts] authenticity". Eirik Vassenden describes the work of Norwegian poet Trygve Skaug as appearing to offer a "simple, almost direct access to the inner self". Vassenden writes that poems such as Rupi Kaur's "if you are not enough for yourself / you will never be enough / for someone else" are "authentic" to such an extent that they are not literary. Kiera Obbard describes how Rupi Kaur uses humour as a rhetorical device in her poetry performances to tell personal stories of trauma and challenge social inequalities. Scholars have also studied the work of specific Instapoets, such as Rupi Kaur, R.M. Drake, Aja Monet, Yrsa Daley-Ward, Nayyirah Waheed, Atticus, Nikita Gill and Trygve Skaug. == Overview == Academics have shown appreciation for the way in which Instapoetry has stimulated interest in poetry in general. Meanwhile, it has been argued that since Instapoets avoid critical evaluations, academics, and the publishing industry, Instapoets qualify more as online celebrities than literary figures. Additionally, although Instapoetry has been characterized as anti-establishment, Alyson Miller noted traditional or even conservative views in the online posts of Instapoets in contrast with the activist views the style is associated with, and that there is a contradiction between "the extra-textual commentary surrounding Instapoetry, particularly by way of interviews and artistic statements, and the content of works which repeatedly reinscribe conservative, patriarchal, and heteronormative worldviews". Thom Young, a poet and high school English teacher, created a parody Instagram page as a way to mock Instapoets and their work, describing it as "fidget-spinner poetry. Like they're just scrolling on their devices, to read something instantly, while the libraries are empty. I think people today don't want to read anything that causes a whole lot of critical thinking." According to Johnathan Ford's piece in the Financial Times, as Instagram's algorithms have limited prospective Instapoets' reach-per-post, it has pushed them to pay to promote their material. Popular Instagram accounts will be promoted to the front of users' feeds, with the app's algorithm, in the view of critics, favoring the spread of bland, inauthentic, or clichéd content while preventing disciplined poetry from reaching new audiences. == Writers described as Instapoets == Rupi Kaur Atticus Amanda Lovelace Tyler Knott Gregson Najwa Zebian Lang Leav Nikita Gill Upile Chisala Tendai M. Shaba Donna Ashworth Trista Mateer
Data refuge
Data Refuge is a public and collaborative project designed to address concerns about federal climate and environmental data that is in danger of being lost. In particular, the initiative addresses five main concerns: What are the best ways to safeguard data? How do federal agencies play a crucial role in collecting, managing, and distributing data? How do government priorities impact data's accessibility? Which projects and research fields depend on federal data? Which data sets are of value to research and local communities, and why? Data Refuge began as a grassroots organization in opposition to government data on climate change and the environment not being archived systemically. Data Refuge's main goal is to collect and allocate data in multiple safe locations to create a sustainable way of archiving old and new data. Data Refuge was initiated in 2016 to protect federal climate and environmental data that is vulnerable under an administration that denies climate change. The system aims to make public research-quality copies of federal climate and environmental data. Data Refuge is supported by the National Geographic Foundation, private donors, Libraries+ Network, Preserving Electronic Governance Initiative (PEGI), the Union of Concerned Scientists (USC), and the Penn Program in Environmental Humanities (PPEH). == Types of data == Data Refuge collects public federal data on the climate and environment in the form of satellite imagery, PDFs, and stories. The data are stored in multiple trusted locations as they are less vulnerable if in only one location, and to ensure accessibility for researchers. Through the Data Rescue events, Data Refuge has accumulated 4 terabytes of data, 30,000 URLs, and 800 participants. === Storytelling === Data Refuge collects stories on vulnerable federal climate and environmental data through: surveys, oral history, photo essays, maps, video shorts, and animations. The stories are archived in a public bank that showcase how federal environmental data support health and safety in communities. Data Stories are collected at Data Rescue events, which are partnered with universities, city and town halls, and advocacy groups. Data stories are collected and used to emphasize the importance of Data Refuge, in how the data on climate change and the environment are being used by people in the United States and across the world for meaningful practices.
FloodAlerts
FloodAlerts is a software application, developed by software specialists Shoothill, which takes real-time flooding information, and displays the data on an interactive Bing map, updating and warning its users when they, their premises or the routes they need to travel could be at risk of flooding. == History == FloodAlerts was launched in 2012, originally as the world's first Facebook flood warning app. == Operation == FloodAlerts is made available free of charge to individuals. Users are able to set up their own monitored locations and receive alerts via the application or their Facebook wall if the locations they are monitoring are at imminent risk of flooding. Hosted in the Cloud, using the Microsoft Windows Azure platform, the FloodAlerts application processes the data received from the Environment Agency, automatically creates the required map tiles, pins and alerts and displays them on an interactive Bing map, updating the content every 15 minutes. Users are able to see the latest information on the map without having to refresh their browser. FloodAlerts can also be provided as a customised risk management solution to businesses that require infrastructure or asset safety monitoring in areas where water levels are rising or receding. == Awards and recognition == FloodAlerts has received The Guardian and Virgin Media Business's 2012 Innovation Nation Awards and was shortlisted as a finalist for a further two national awards: the UK IT Industry Awards for Innovation and Entrepreneurship and The Institution of Engineering and Technology Innovation Awards for Information Technology. == In the press == The FloodAlerts application was reviewed on the BBC website. It was also reviewed on BBC Click.
Bus encryption
Bus encryption is the use of encrypted program instructions on a data bus in a computer that includes a secure cryptoprocessor for executing the encrypted instructions. Bus encryption is used primarily in electronic systems that require high security, such as automated teller machines, TV set-top boxes, and secure data communication devices such as two-way digital radios. Bus encryption can also mean encrypted data transmission on a data bus from one processor to another processor. For example, from the CPU to a GPU which does not require input of encrypted instructions. Such bus encryption is used by Windows Vista and newer Microsoft operating systems to protect certificates, BIOS, passwords, and program authenticity. PVP-UAB (Protected Video Path) provides bus encryption of premium video content in PCs as it passes over the PCIe bus to graphics cards to enforce digital rights management. The need for bus encryption arises when multiple people have access to the internal circuitry of an electronic system, either because they service and repair such systems, stock spare components for the systems, own the system, steal the system, or find a lost or abandoned system. Bus encryption is necessary not only to prevent tampering of encrypted instructions that may be easily discovered on a data bus or during data transmission, but also to prevent discovery of decrypted instructions that may reveal security weaknesses that an intruder can exploit. In TV set-top boxes, it is necessary to download program instructions periodically to customer's units to provide new features and to fix bugs. These new instructions are encrypted before transmission, but must also remain secure on data buses and during execution to prevent the manufacture of unauthorized cable TV boxes. This can be accomplished by secure crypto-processors that read encrypted instructions on the data bus from external data memory, decrypt the instructions in the cryptoprocessor, and execute the instructions in the same cryptoprocessor.