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Anaconda (Python distribution)
Anaconda is an open source data science and artificial intelligence distribution platform for the Python programming language. Developed by Anaconda, Inc., an American company founded in 2012, the platform is used to develop and manage data science and AI projects. In 2024, Anaconda Inc. has about 300 employees and 45 million users. == History == Co-founded in Austin, Texas in 2012 as Continuum Analytics by Peter Wang and Travis Oliphant, Anaconda Inc. operates from the United States and Europe. Anaconda Inc. developed Conda, a cross-platform, language-agnostic binary package manager. It also launched PyData community workshops and the Jupyter Cloud Notebook service (Wakari.io). In 2013, it received funding from DARPA. In 2015, the company had two million users including 200 of the Fortune 500 companies and raised $24 million in a Series A funding round led by General Catalyst and BuildGroup. Anaconda secured an additional $30 million in funding in 2021. Continuum Analytics rebranded as Anaconda in 2017. That year, it announced the release of Anaconda Enterprise 5, an integration with Microsoft Azure, and had over 13 million users by year's end. In 2022, it released Anaconda Business; new integrations with Snowflake and others; and the open-source PyScript. It also acquired PythonAnywhere, while Anaconda's user base exceeded 30 million in 2022. In 2023, Anaconda released Python in Excel, a new integration with Microsoft Excel, and launched PyScript.com. The company made a series of investments in AI during 2024. That February, Anaconda partnered with IBM to import its repository of Python packages into Watsonx, IBM's generative AI platform. The same year, Anaconda joined IBM's AI Alliance and released an integration with Teradata and Lenovo. In 2024, Anaconda's user base reached 45 million users and Barry Libert was named company CEO, after serving on Anaconda's board of directors. He was succeeded as CEO in October 2025 by David DeSanto, who also became a company director. In May 2025, the company introduced the first unified AI platform for Open Source, Anaconda AI Platform, a central control for AI workflows that enables customization in Python-based enterprise AI development. That July, after reaching over $150 million in a Series C funding round, Anaconda was evaluated at about $1.5 billion. == Overview == Anaconda distribution comes with over 300 packages automatically installed, and over 7,500 additional open-source packages can be installed from the Anaconda repository as well as the Conda package and virtual environment manager. It also includes a GUI, Anaconda Navigator, as a graphical alternative to the command-line interface (CLI). Conda was developed to address dependency conflicts native to the pip package manager, which would automatically install any dependent Python packages without checking for conflicts with previously installed packages (until its version 20.3, which later implemented consistent dependency resolution). The Conda package manager's historical differentiation analyzed and resolved these installation conflicts. Anaconda is a distribution of the Python programming language (and previously also R) for scientific computing (data science, machine learning applications, large-scale data processing, predictive analytics, etc.), that aims to simplify package management and deployment. Anaconda distribution includes data-science packages suitable for Windows, Linux, and macOS. Other company products include Anaconda Free, and subscription-based Starter, Business and Enterprise. Anaconda's business tier offers Package Security Manager. Package versions in Anaconda are managed by the package management system Conda, which was spun out as a separate open-source package as useful both independently and for applications other than Python. There is also a small, bootstrap version of Anaconda called Miniconda, which includes only Conda, Python, the packages they depend on, and a small number of other packages. Open source packages can be individually installed from the Anaconda repository, Anaconda Cloud (anaconda.org), or the user's own private repository or mirror, using the conda install command. Anaconda, Inc. compiles and builds the packages available in the Anaconda repository itself, and provides binaries for Windows 32/64 bit, Linux 64 bit and MacOS 64-bit (Intel, Apple Silicon). Anything available on PyPI may be installed into a Conda environment using pip, and Conda will keep track of what it has installed and what pip has installed. Custom packages can be made using the conda build command, and can be shared with others by uploading them to Anaconda Cloud, PyPI or other repositories. The default installation of Anaconda2 includes Python 2.7 and Anaconda3 includes Python 3.7. However, it is possible to create new environments that include any version of Python packaged with Conda. === Anaconda Navigator === Anaconda Navigator is a desktop graphical user interface (GUI) included in Anaconda distribution that allows users to launch applications and manage Conda packages, environments and channels without using command-line commands. Navigator can search for packages on Anaconda Cloud or in a local Anaconda Repository, install them in an environment, run the packages and update them. It is available for Windows, macOS and Linux. The following applications are available by default in Navigator: JupyterLab Jupyter Notebook QtConsole Spyder Glue Orange RStudio Visual Studio Code === Conda === Conda is an open source, cross-platform, language-agnostic package manager and environment management system that installs, runs, and updates packages and their dependencies. It was created for Python programs, but it can package and distribute software for any language, including multi-language projects. The Conda package and environment manager is included in all versions of Anaconda, Miniconda, and Anaconda Repository. == Anaconda.org == Anaconda Cloud is a package management service by Anaconda where users can find, access, store and share public and private notebooks, environments, and Conda and PyPI packages. Cloud hosts useful Python packages, notebooks and environments for a wide variety of applications. Users do not need to log in or to have a Cloud account, to search for public packages, download and install them. Users can build new Conda packages using Conda-build and then use the Anaconda Client CLI to upload packages to Anaconda.org. Notebooks users can be aided with writing and debugging code with Anaconda's AI Assistant.
Random feature
Random features (RF) are a technique used in machine learning to approximate kernel methods, introduced by Ali Rahimi and Ben Recht in their 2007 paper "Random Features for Large-Scale Kernel Machines", and extended by. RF uses a Monte Carlo approximation to kernel functions by randomly sampled feature maps. It is used for datasets that are too large for traditional kernel methods like support vector machine, kernel ridge regression, and gaussian process. == Mathematics == === Kernel method === Given a feature map ϕ : R d → V {\textstyle \phi :\mathbb {R} ^{d}\to V} , where V {\textstyle V} is a Hilbert space (more specifically, a reproducing kernel Hilbert space), the kernel trick replaces inner products in feature space ⟨ ϕ ( x i ) , ϕ ( x j ) ⟩ V {\displaystyle \langle \phi (x_{i}),\phi (x_{j})\rangle _{V}} by a kernel function k ( x i , x j ) : R d × R d → R {\displaystyle k(x_{i},x_{j}):\mathbb {R} ^{d}\times \mathbb {R} ^{d}\to \mathbb {R} } Kernel methods replaces linear operations in high-dimensional space by operations on the kernel matrix: K X := [ k ( x i , x j ) ] i , j ∈ 1 : N {\displaystyle K_{X}:=[k(x_{i},x_{j})]_{i,j\in 1:N}} where N {\textstyle N} is the number of data points. === Random kernel method === The problem with kernel methods is that the kernel matrix K X {\textstyle K_{X}} has size N × N {\textstyle N\times N} . This becomes computationally infeasible when N {\textstyle N} reaches the order of a million. The random kernel method replaces the kernel function k {\textstyle k} by an inner product in low-dimensional feature space R D {\textstyle \mathbb {R} ^{D}} : k ( x , y ) ≈ ⟨ z ( x ) , z ( y ) ⟩ {\displaystyle k(x,y)\approx \langle z(x),z(y)\rangle } where z {\textstyle z} is a randomly sampled feature map z : R d → R D {\textstyle z:\mathbb {R} ^{d}\to \mathbb {R} ^{D}} . This converts kernel linear regression into linear regression in feature space, kernel SVM into SVM in feature space, etc. Since we have K X ≈ Z X T Z X {\displaystyle K_{X}\approx Z_{X}^{T}Z_{X}} where Z X = [ z ( x 1 ) , … , z ( x N ) ] {\displaystyle Z_{X}=[z(x_{1}),\dots ,z(x_{N})]} , these methods no longer involve matrices of size O ( N 2 ) {\textstyle O(N^{2})} , but only random feature matrices of size O ( D N ) {\textstyle O(DN)} . == Random Fourier feature == === Radial basis function kernel === The radial basis function (RBF) kernel on two samples x i , x j ∈ R d {\displaystyle x_{i},x_{j}\in \mathbb {R} ^{d}} is defined as k ( x i , x j ) = exp ( − ‖ x i − x j ‖ 2 2 σ 2 ) {\displaystyle k(x_{i},x_{j})=\exp \left(-{\frac {\|x_{i}-x_{j}\|^{2}}{2\sigma ^{2}}}\right)} where ‖ x i − x j ‖ 2 {\displaystyle \|x_{i}-x_{j}\|^{2}} is the squared Euclidean distance and σ {\displaystyle \sigma } is a free parameter defining the shape of the kernel. It can be approximated by a random Fourier feature map z : R d → R 2 D {\displaystyle z:\mathbb {R} ^{d}\to \mathbb {R} ^{2D}} : z ( x ) := 1 D [ cos ⟨ ω 1 , x ⟩ , sin ⟨ ω 1 , x ⟩ , … , cos ⟨ ω D , x ⟩ , sin ⟨ ω D , x ⟩ ] T {\displaystyle z(x):={\frac {1}{\sqrt {D}}}[\cos \langle \omega _{1},x\rangle ,\sin \langle \omega _{1},x\rangle ,\ldots ,\cos \langle \omega _{D},x\rangle ,\sin \langle \omega _{D},x\rangle ]^{T}} where ω 1 , . . . , ω D {\displaystyle \omega _{1},...,\omega _{D}} are IID samples from the multidimensional normal distribution N ( 0 , σ − 2 I ) {\displaystyle N(0,\sigma ^{-2}I)} . Since cos , sin {\displaystyle \cos ,\sin } are bounded, there is a stronger convergence guarantee by Hoeffding's inequality. === Random Fourier features === By Bochner's theorem, the above construction can be generalized to arbitrary positive definite shift-invariant kernel k ( x , y ) = k ( x − y ) {\displaystyle k(x,y)=k(x-y)} . Define its Fourier transform p ( ω ) = 1 2 π ∫ R d e − j ⟨ ω , Δ ⟩ k ( Δ ) d Δ {\displaystyle p(\omega )={\frac {1}{2\pi }}\int _{\mathbb {R} ^{d}}e^{-j\langle \omega ,\Delta \rangle }k(\Delta )d\Delta } then ω 1 , . . . , ω D {\displaystyle \omega _{1},...,\omega _{D}} are sampled IID from the probability distribution with probability density p {\displaystyle p} . This applies for other kernels like the Laplace kernel and the Cauchy kernel. === Neural network interpretation === Given a random Fourier feature map z {\displaystyle z} , training the feature on a dataset by featurized linear regression is equivalent to fitting complex parameters θ 1 , … , θ D ∈ C {\displaystyle \theta _{1},\dots ,\theta _{D}\in \mathbb {C} } such that f θ ( x ) = R e ( ∑ k θ k e i ⟨ ω k , x ⟩ ) {\displaystyle f_{\theta }(x)=\mathrm {Re} \left(\sum _{k}\theta _{k}e^{i\langle \omega _{k},x\rangle }\right)} which is a neural network with a single hidden layer, with activation function t ↦ e i t {\displaystyle t\mapsto e^{it}} , zero bias, and the parameters in the first layer frozen. In the overparameterized case, when 2 D ≥ N {\displaystyle 2D\geq N} , the network linearly interpolates the dataset { ( x i , y i ) } i ∈ 1 : N {\displaystyle \{(x_{i},y_{i})\}_{i\in 1:N}} , and the network parameters is the least-norm solution: θ ^ = arg min θ ∈ C D , f θ ( x k ) = y k ∀ k ∈ 1 : N ‖ θ ‖ {\displaystyle {\hat {\theta }}=\arg \min _{\theta \in \mathbb {C} ^{D},f_{\theta }(x_{k})=y_{k}\forall k\in 1:N}\|\theta \|} At the limit of D → ∞ {\displaystyle D\to \infty } , the L2 norm ‖ θ ^ ‖ → ‖ f K ‖ H {\displaystyle \|{\hat {\theta }}\|\to \|f_{K}\|_{H}} where f K {\displaystyle f_{K}} is the interpolating function obtained by the kernel regression with the original kernel, and ‖ ⋅ ‖ H {\displaystyle \|\cdot \|_{H}} is the norm in the reproducing kernel Hilbert space for the kernel. == Other examples == === Random binning features === A random binning features map partitions the input space using randomly shifted grids at randomly chosen resolutions and assigns to an input point a binary bit string that corresponds to the bins in which it falls. The grids are constructed so that the probability that two points x i , x j ∈ R d {\displaystyle x_{i},x_{j}\in \mathbb {R} ^{d}} are assigned to the same bin is proportional to K ( x i , x j ) {\displaystyle K(x_{i},x_{j})} . The inner product between a pair of transformed points is proportional to the number of times the two points are binned together, and is therefore an unbiased estimate of K ( x i , x j ) {\displaystyle K(x_{i},x_{j})} . Since this mapping is not smooth and uses the proximity between input points, Random Binning Features works well for approximating kernels that depend only on the L 1 {\displaystyle L_{1}} distance between datapoints. === Orthogonal random features === Orthogonal random features uses a random orthogonal matrix instead of a random Fourier matrix. == Historical context == In NIPS 2006, deep learning had just become competitive with linear models like PCA and linear SVMs for large datasets, and people speculated about whether it could compete with kernel SVMs. However, there was no way to train kernel SVM on large datasets. The two authors developed the random feature method to train those. It was then found that the O ( 1 / D ) {\displaystyle O(1/D)} variance bound did not match practice: the variance bound predicts that approximation to within 0.01 {\displaystyle 0.01} requires D ∼ 10 4 {\displaystyle D\sim 10^{4}} , but in practice required only ∼ 10 2 {\displaystyle \sim 10^{2}} . Attempting to discover what caused this led to the subsequent two papers.
Sample complexity
The sample complexity of a machine learning algorithm represents the number of training-samples that it needs in order to successfully learn a target function. More precisely, the sample complexity is the number of training-samples that we need to supply to the algorithm, so that the function returned by the algorithm is within an arbitrarily small error of the best possible function, with probability arbitrarily close to 1. There are two variants of sample complexity: The weak variant fixes a particular input-output distribution; The strong variant takes the worst-case sample complexity over all input-output distributions. The No free lunch theorem, discussed below, proves that, in general, the strong sample complexity is infinite, i.e. that there is no algorithm that can learn the globally-optimal target function using a finite number of training samples. However, if we are only interested in a particular class of target functions (e.g., only linear functions) then the sample complexity is finite, and it depends linearly on the VC dimension on the class of target functions. == Definition == Let X {\displaystyle X} be a space which we call the input space, and Y {\displaystyle Y} be a space which we call the output space, and let Z {\displaystyle Z} denote the product X × Y {\displaystyle X\times Y} . For example, in the setting of binary classification, X {\displaystyle X} is typically a finite-dimensional vector space and Y {\displaystyle Y} is the set { − 1 , 1 } {\displaystyle \{-1,1\}} . Fix a hypothesis space H {\displaystyle {\mathcal {H}}} of functions h : X → Y {\displaystyle h\colon X\to Y} . A learning algorithm over H {\displaystyle {\mathcal {H}}} is a computable map from Z {\displaystyle Z} to H {\displaystyle {\mathcal {H}}} . In other words, it is an algorithm that takes as input a finite sequence of training samples and outputs a function from X {\displaystyle X} to Y {\displaystyle Y} . Typical learning algorithms include empirical risk minimization, without or with Tikhonov regularization. Fix a loss function L : Y × Y → R ≥ 0 {\displaystyle {\mathcal {L}}\colon Y\times Y\to \mathbb {R} _{\geq 0}} , for example, the square loss L ( y , y ′ ) = ( y − y ′ ) 2 {\displaystyle {\mathcal {L}}(y,y')=(y-y')^{2}} , where h ( x ) = y ′ {\displaystyle h(x)=y'} . For a given distribution ρ {\displaystyle \rho } on X × Y {\displaystyle X\times Y} , the expected risk of a hypothesis (a function) h ∈ H {\displaystyle h\in {\mathcal {H}}} is E ( h ) := E ρ [ L ( h ( x ) , y ) ] = ∫ X × Y L ( h ( x ) , y ) d ρ ( x , y ) {\displaystyle {\mathcal {E}}(h):=\mathbb {E} _{\rho }[{\mathcal {L}}(h(x),y)]=\int _{X\times Y}{\mathcal {L}}(h(x),y)\,d\rho (x,y)} In our setting, we have h = A ( S n ) {\displaystyle h={\mathcal {A}}(S_{n})} , where A {\displaystyle {\mathcal {A}}} is a learning algorithm and S n = ( ( x 1 , y 1 ) , … , ( x n , y n ) ) ∼ ρ n {\displaystyle S_{n}=((x_{1},y_{1}),\ldots ,(x_{n},y_{n}))\sim \rho ^{n}} is a sequence of vectors which are all drawn independently from ρ {\displaystyle \rho } . Define the optimal risk E H ∗ = inf h ∈ H E ( h ) . {\displaystyle {\mathcal {E}}_{\mathcal {H}}^{}={\underset {h\in {\mathcal {H}}}{\inf }}{\mathcal {E}}(h).} Set h n = A ( S n ) {\displaystyle h_{n}={\mathcal {A}}(S_{n})} , for each sample size n {\displaystyle n} . h n {\displaystyle h_{n}} is a random variable and depends on the random variable S n {\displaystyle S_{n}} , which is drawn from the distribution ρ n {\displaystyle \rho ^{n}} . The algorithm A {\displaystyle {\mathcal {A}}} is called consistent if E ( h n ) {\displaystyle {\mathcal {E}}(h_{n})} probabilistically converges to E H ∗ {\displaystyle {\mathcal {E}}_{\mathcal {H}}^{}} . In other words, for all ϵ , δ > 0 {\displaystyle \epsilon ,\delta >0} , there exists a positive integer N {\displaystyle N} , such that, for all sample sizes n ≥ N {\displaystyle n\geq N} , we have Pr ρ n [ E ( h n ) − E H ∗ ≥ ε ] < δ . {\displaystyle \Pr _{\rho ^{n}}[{\mathcal {E}}(h_{n})-{\mathcal {E}}_{\mathcal {H}}^{}\geq \varepsilon ]<\delta .} The sample complexity of A {\displaystyle {\mathcal {A}}} is then the minimum N {\displaystyle N} for which this holds, as a function of ρ , ϵ {\displaystyle \rho ,\epsilon } , and δ {\displaystyle \delta } . We write the sample complexity as N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} to emphasize that this value of N {\displaystyle N} depends on ρ , ϵ {\displaystyle \rho ,\epsilon } , and δ {\displaystyle \delta } . If A {\displaystyle {\mathcal {A}}} is not consistent, then we set N ( ρ , ϵ , δ ) = ∞ {\displaystyle N(\rho ,\epsilon ,\delta )=\infty } . If there exists an algorithm for which N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} is finite, then we say that the hypothesis space H {\displaystyle {\mathcal {H}}} is learnable. In others words, the sample complexity N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} defines the rate of consistency of the algorithm: given a desired accuracy ϵ {\displaystyle \epsilon } and confidence δ {\displaystyle \delta } , one needs to sample N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} data points to guarantee that the risk of the output function is within ϵ {\displaystyle \epsilon } of the best possible, with probability at least 1 − δ {\displaystyle 1-\delta } . In probably approximately correct (PAC) learning, one is concerned with whether the sample complexity is polynomial, that is, whether N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} is bounded by a polynomial in 1 / ϵ {\displaystyle 1/\epsilon } and 1 / δ {\displaystyle 1/\delta } . If N ( ρ , ϵ , δ ) {\displaystyle N(\rho ,\epsilon ,\delta )} is polynomial for some learning algorithm, then one says that the hypothesis space H {\displaystyle {\mathcal {H}}} is PAC-learnable. This is a stronger notion than being learnable. == Unrestricted hypothesis space: infinite sample complexity == One can ask whether there exists a learning algorithm so that the sample complexity is finite in the strong sense, that is, there is a bound on the number of samples needed so that the algorithm can learn any distribution over the input-output space with a specified target error. More formally, one asks whether there exists a learning algorithm A {\displaystyle {\mathcal {A}}} , such that, for all ϵ , δ > 0 {\displaystyle \epsilon ,\delta >0} , there exists a positive integer N {\displaystyle N} such that for all n ≥ N {\displaystyle n\geq N} , we have sup ρ ( Pr ρ n [ E ( h n ) − E H ∗ ≥ ε ] ) < δ , {\displaystyle \sup _{\rho }\left(\Pr _{\rho ^{n}}[{\mathcal {E}}(h_{n})-{\mathcal {E}}_{\mathcal {H}}^{}\geq \varepsilon ]\right)<\delta ,} where h n = A ( S n ) {\displaystyle h_{n}={\mathcal {A}}(S_{n})} , with S n = ( ( x 1 , y 1 ) , … , ( x n , y n ) ) ∼ ρ n {\displaystyle S_{n}=((x_{1},y_{1}),\ldots ,(x_{n},y_{n}))\sim \rho ^{n}} as above. The No Free Lunch Theorem says that without restrictions on the hypothesis space H {\displaystyle {\mathcal {H}}} , this is not the case, i.e., there always exist "bad" distributions for which the sample complexity is arbitrarily large. Thus, in order to make statements about the rate of convergence of the quantity sup ρ ( Pr ρ n [ E ( h n ) − E H ∗ ≥ ε ] ) , {\displaystyle \sup _{\rho }\left(\Pr _{\rho ^{n}}[{\mathcal {E}}(h_{n})-{\mathcal {E}}_{\mathcal {H}}^{}\geq \varepsilon ]\right),} one must either constrain the space of probability distributions ρ {\displaystyle \rho } , e.g. via a parametric approach, or constrain the space of hypotheses H {\displaystyle {\mathcal {H}}} , as in distribution-free approaches. == Restricted hypothesis space: finite sample-complexity == The latter approach leads to concepts such as VC dimension and Rademacher complexity which control the complexity of the space H {\displaystyle {\mathcal {H}}} . A smaller hypothesis space introduces more bias into the inference process, meaning that E H ∗ {\displaystyle {\mathcal {E}}_{\mathcal {H}}^{}} may be greater than the best possible risk in a larger space. However, by restricting the complexity of the hypothesis space it becomes possible for an algorithm to produce more uniformly consistent functions. This trade-off leads to the concept of regularization. It is a theorem from VC theory that the following three statements are equivalent for a hypothesis space H {\displaystyle {\mathcal {H}}} : H {\displaystyle {\mathcal {H}}} is PAC-learnable. The VC dimension of H {\displaystyle {\mathcal {H}}} is finite. H {\displaystyle {\mathcal {H}}} is a uniform Glivenko-Cantelli class. This gives a way to prove that certain hypothesis spaces are PAC learnable, and by extension, learnable. === An example of a PAC-learnable hypothesis space === X = R d , Y = { − 1 , 1 } {\displaystyle X=\mathbb {R} ^{d},Y=\{-1,1\}} , and let H {\displaystyle {\mathcal {H}}} be the space of affine functions on X {\displaystyle X} , that is, functions of the form x ↦ ⟨ w , x ⟩ + b {\displaystyle x\mapsto \langl
Biohybrid system
Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.
Oracle Cloud Platform
Oracle Cloud Platform refers to a Platform as a Service (PaaS) offerings by Oracle Corporation as part of Oracle Cloud Infrastructure. These offerings are used to build, deploy, integrate and extend applications in the cloud. The offerings support a variety of programming languages, databases, tools and frameworks including Oracle-specific, open source and third-party software and systems. == Deployment models == Oracle Cloud Platform offers public, private and hybrid cloud deployment models. == Architecture == Oracle Cloud Platform provides both Infrastructure as a Service (IaaS) and Platform as a Service (PaaS). The infrastructure is offered through a global network of Oracle managed data centers. Oracle deploys their cloud in Regions. Inside each Region are at least three fault-independent Availability Domains. Each of these Availability Domains contains an independent data center with power, thermal and network isolation. Oracle Cloud is generally available in North America, EMEA, APAC and Japan with announced South America and US Govt. regions coming soon.
MLOps
MLOps or ML Ops is a paradigm that aims to deploy and maintain machine learning models in production reliably and efficiently. It bridges the gap between machine learning development and production operations, ensuring that models are robust, scalable, and aligned with business goals. The word is a compound of "machine learning" and the continuous delivery practice (CI/CD) of DevOps in the software field. Machine learning models are tested and developed in isolated experimental systems. When an algorithm is ready to be launched, MLOps is practiced between data scientists, DevOps, and machine learning engineers to transition the algorithm to production systems. Similar to DevOps or DataOps approaches, MLOps seeks to increase automation and improve the quality of production models, while also focusing on business and regulatory requirements. While MLOps started as a set of best practices, it is slowly evolving into an independent approach to ML lifecycle management. MLOps applies to the entire lifecycle - from integrating with model generation (software development lifecycle, continuous integration/continuous delivery), orchestration, and deployment, to health, diagnostics, governance, and business metrics. == Definition == MLOps is a paradigm, including aspects like best practices, sets of concepts, as well as a development culture when it comes to the end-to-end conceptualization, implementation, monitoring, deployment, and scalability of machine learning products. Most of all, it is an engineering practice that leverages three contributing disciplines: machine learning, software engineering (especially DevOps), and data engineering. MLOps is aimed at productionizing machine learning systems by bridging the gap between development (Dev) and operations (Ops). Essentially, MLOps aims to facilitate the creation of machine learning products by leveraging these principles: CI/CD automation, workflow orchestration, reproducibility; versioning of data, model, and code; collaboration; continuous ML training and evaluation; ML metadata tracking and logging; continuous monitoring; and feedback loops. == History == Interest in operationalizing machine learning systems began to grow in the mid-2010s as ML projects started moving from experimentation to production use. The challenges associated with sustaining such systems were highlighted in a 2015 paper. The predicted growth in machine learning included an estimated doubling of ML pilots and implementations from 2017 to 2018, and again from 2018 to 2020. Reports show a majority (up to 88%) of corporate machine learning initiatives are struggling to move beyond test stages. However, those organizations that actually put machine learning into production saw a 3–15% profit margin increases. The MLOps market size was USD 2,191.8 Million in 2024, and is projected to be USD 16,613.4 Million in 2030. == Architecture == Machine Learning systems can be categorized in eight different categories: data collection, data processing, feature engineering, data labeling, model design, model training and optimization, endpoint deployment, and endpoint monitoring. Each step in the machine learning lifecycle is built in its own system, but requires interconnection. These are the minimum systems that enterprises need to scale machine learning within their organization. == Goals == There are a number of goals enterprises want to achieve through MLOps systems successfully implementing ML across the enterprise, including: Deployment and automation Reproducibility of models and predictions Diagnostics Governance and regulatory compliance Scalability Collaboration Business uses Monitoring and management A standard practice, such as MLOps, takes into account each of the aforementioned areas, which can help enterprises optimize workflows and avoid issues during implementation. Vendors such as Adaptive ML deliver commercial reinforcement learning operations (RLOps) and MLOps-infrastructure, targeting organizations deploying large language models in production. A common architecture of an MLOps system would include data science platforms where models are constructed and the analytical engines where computations are performed, with the MLOps tool orchestrating the movement of machine learning models, data and outcomes between the systems.