Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.
Multimodal representation learning
Multimodal representation learning is a subfield of representation learning focused on integrating and interpreting information from different modalities, such as text, images, audio, or video, by projecting them into a shared latent space. This allows for semantically similar content across modalities to be mapped to nearby points within that space, facilitating a unified understanding of diverse data types. By automatically learning meaningful features from each modality and capturing their inter-modal relationships, multimodal representation learning enables a unified representation that enhances performance in cross-media analysis tasks such as video classification, event detection, and sentiment analysis. It also supports cross-modal retrieval and translation, including image captioning, video description, and text-to-image synthesis. == Motivation == The primary motivations for multimodal representation learning arise from the inherent nature of real-world data and the limitations of unimodal approaches. Since multimodal data offers complementary and supplementary information about an object or event from different perspectives, it is more informative than relying on a single modality. A key motivation is to narrow the heterogeneity gap that exists between different modalities by projecting their features into a shared semantic subspace. This allows semantically similar content across modalities to be represented by similar vectors, facilitating the understanding of relationships and correlations between them. Multimodal representation learning aims to leverage the unique information provided by each modality to achieve a more comprehensive and accurate understanding of concepts. These unified representations are crucial for improving performance in various cross-media analysis tasks such as video classification, event detection, and sentiment analysis. They also enable cross-modal retrieval, allowing users to search and retrieve content across different modalities. Additionally, it facilitates cross-modal translation, where information can be converted from one modality to another, as seen in applications like image captioning and text-to-image synthesis. The abundance of ubiquitous multimodal data in real-world applications, including understudied areas like healthcare, finance, and human-computer interaction (HCI), further motivates the development of effective multimodal representation learning techniques. == Approaches and methods == === Canonical-correlation analysis based methods === Canonical-correlation analysis (CCA) was first introduced in 1936 by Harold Hotelling and is a fundamental approach for multimodal learning. CCA aims to find linear relationships between two sets of variables. Given two data matrices X ∈ R n × p {\displaystyle X\in \mathbb {R} ^{n\times p}} and Y ∈ R n × q {\displaystyle Y\in \mathbb {R} ^{n\times q}} representing different modalities, CCA finds projection vectors w x ∈ R p {\displaystyle w_{x}\in \mathbb {R} ^{p}} and w y ∈ R q {\displaystyle w_{y}\in \mathbb {R} ^{q}} that maximizes the correlation between the projected variables: ρ = max w x , w y w x ⊤ Σ x y w y w x ⊤ Σ x x w x w y ⊤ Σ y y w y {\displaystyle \rho =\max _{w_{x},w_{y}}{\frac {w_{x}^{\top }\Sigma _{xy}w_{y}}{{\sqrt {w_{x}^{\top }\Sigma _{xx}w_{x}}}{\sqrt {w_{y}^{\top }\Sigma _{yy}w_{y}}}}}} such that Σ x x {\displaystyle \Sigma _{xx}} and Σ y y {\displaystyle \Sigma _{yy}} are the within-modality covariance matrices, and Σ x y {\displaystyle \Sigma _{xy}} is the between-modality covariance matrix. However, standard CCA is limited by its linearity, which led to the development of nonlinear extensions, such as kernel CCA and deep CCA. ==== Kernel CCA ==== Kernel canonical correlation analysis (KCCA) extends traditional CCA to capture nonlinear relationships between modalities by implicitly mapping the data into high dimensional feature spaces using kernel functions. Given kernel functions K x {\displaystyle K_{x}} and K y {\displaystyle K_{y}} with corresponding Gram matrices K x ∈ R n × n {\displaystyle K_{x}\in \mathbb {R} ^{n\times n}} and K y ∈ R n × n {\displaystyle K_{y}\in \mathbb {R} ^{n\times n}} , KCCA seeks coefficients α {\displaystyle \alpha } and β {\displaystyle \beta } that maximize: ρ = max α , β α ⊤ K x K y β α ⊤ K x 2 α β ⊤ K y 2 β {\displaystyle \rho =\max _{\alpha ,\beta }{\frac {\alpha ^{\top }K_{x}Ky\beta }{{\sqrt {\alpha ^{\top }K_{x}^{2}\alpha }}{\sqrt {\beta ^{\top }K_{y}^{2}\beta }}}}} To prevent overfitting, regularization terms are typically added, resulting in: ρ = max α , β α T K x K y β α T ( K x 2 + λ x K x ) α β T ( K y 2 + λ y K y ) β {\displaystyle \rho =\max _{\alpha ,\beta }{\frac {\alpha ^{T}K_{x}K_{y}\beta }{{\sqrt {\alpha ^{T}\left(K_{x}^{2}+\lambda _{x}K_{x}\right)\alpha }}{\sqrt {\;\beta ^{T}\left(K_{y}^{2}+\lambda _{y}K_{y}\right)\beta }}}}} where λ x {\displaystyle \lambda _{x}} and λ y {\displaystyle \lambda _{y}} are regularization parameters. KCCA has proven effective for tasks such as cross-modal retrieval and semantic analysis, though it faces computational challenges with large datasets due to its O ( n 2 ) {\displaystyle O(n^{2})} memory requirement for sorting kernel matrices. KCCA was proposed independently by several researchers. ==== Deep CCA ==== Deep canonical correlation analysis (DCCA), introduced in 2013, employs neural networks to learn nonlinear transformations for maximizing the correlation between modalities. DCCA uses separate neural networks f x {\displaystyle f_{x}} and f y {\displaystyle f_{y}} for each modality to transform the original data before applying CCA: max W x , W y , θ x , θ y corr ( f x ( X ; θ x ) , f y ( Y ; θ y ) ) {\displaystyle \max _{W_{x},W_{y},\theta _{x},\theta _{y}}\operatorname {corr} \left(f_{x}(X;\theta _{x}),f_{y}(Y;\theta _{y})\right)} where θ x {\displaystyle \theta _{x}} and θ y {\displaystyle \theta _{y}} represent the parameters of the neural networks, and W x {\displaystyle W_{x}} and W y {\displaystyle W_{y}} are the CCA projection matrices. The correlation objective is computed as: corr ( H x , H y ) = tr ( T − 1 / 2 H x T H y S − 1 / 2 ) {\displaystyle \operatorname {corr} (H_{x},H_{y})=\operatorname {tr} \left(T^{-1/2}H_{x}^{T}H_{y}S^{-1/2}\right)} where H x = f x ( X ) {\displaystyle H_{x}=f_{x}(X)} and H y = f y ( Y ) {\displaystyle H_{y}=f_{y}(Y)} are the network outputs, T = H x T H x + r x I {\displaystyle T=H_{x}^{T}H_{x}+r_{x}I} , S = H y T H y + r y I {\displaystyle S=H_{y}^{T}H_{y}+r_{y}I} and r x , r y {\displaystyle r_{x},r_{y}} are the regularization parameters. DCCA overcomes the limitations of linear CCA and kernel CCA by learning complex nonlinear relationships while maintaining computational efficiency for large datasets through mini-batch optimization. === Graph-based methods === Graph-based approaches for multimodal representation learning leverage graph structure to model relationships between entities across different modalities. These methods typically represent each modality as a graph and then learn embedding that preserve cross-modal similarities, enabling more effective joint representation of heterogeneous data. One such method is cross-modal graph neural networks (CMGNNs) that extend traditional graph neural networks (GNNs) to handle data from multiple modalities by constructing graphs that capture both intra-modal and inter-modal relationships. These networks model interactions across modalities by representing them as nodes and their relationships as edges. Other graph-based methods include Probabilistic Graphical Models (PGMs) such as deep belief networks (DBN) and deep Boltzmann machines (DBM). These models can learn a joint representation across modalities, for instance, a multimodal DBN achieves this by adding a shared restricted Boltzmann Machine (RBM) hidden layer on top of modality-specific DBNs. Additionally, the structure of data in some domains like Human-Computer Interaction (HCI), such as the view hierarchy of app screens, can potentially be modeled using graph-like structures. The field of graph representation learning is also relevant, with ongoing progress in developing evaluation benchmarks. === Diffusion maps === Another set of methods relevant to multimodal representation learning are based on diffusion maps and their extensions to handle multiple modalities. ==== Multi-view diffusion maps ==== Multi-view diffusion maps address the challenge of achieving multi-view dimensionality reduction by effectively utilizing the availability of multiple views to extract a coherent low-dimensional representation of the data. The core idea is to exploit both the intrinsic relations within each view and the mutual relations between the different views, defining a cross-view model where a random walk process implicitly hops between objects in different views. A multi-view kernel matrix is constructed by combining these relations, defining a cross-view diffusion process and associ
Cognitive philology
Cognitive philology is the science that studies written and oral texts as the product of human mental processes. Studies in cognitive philology compare documentary evidence emerging from textual investigations with results of experimental research, especially in the fields of cognitive and ecological psychology, neurosciences and artificial intelligence. "The point is not the text, but the mind that made it". Cognitive Philology aims to foster communication between literary, textual, philological disciplines on the one hand and researches across the whole range of the cognitive, evolutionary, ecological and human sciences on the other. Cognitive philology: investigates transmission of oral and written text, and categorization processes which lead to classification of knowledge, mostly relying on the information theory; studies how narratives emerge in so called natural conversation and selective process which lead to the rise of literary standards for storytelling, mostly relying on embodied semantics; explores the evolutive and evolutionary role played by rhythm and metre in human ontogenetic and phylogenetic development and the pertinence of the semantic association during processing of cognitive maps; Provides the scientific ground for multimedia critical editions of literary texts. Among the founding thinkers and noteworthy scholars devoted to such investigations are: Alan Richardson: Studies Theory of Mind in early-modern and contemporary literature. Anatole Pierre Fuksas Benoît de Cornulier David Herman: Professor of English at North Carolina State University and an adjunct professor of linguistics at Duke University. He is the author of "Universal Grammar and Narrative Form" and the editor of "Narratologies: New Perspectives on Narrative Analysis". Domenico Fiormonte François Recanati Gilles Fauconnier, a professor in Cognitive science at the University of California, San Diego. He was one of the founders of cognitive linguistics in the 1970s through his work on pragmatic scales and mental spaces. His research explores the areas of conceptual integration and compressions of conceptual mappings in terms of the emergent structure in language. Julián Santano Moreno Luca Nobile Manfred Jahn in Germany Mark Turner Paolo Canettieri
Cognitive philology
Cognitive philology is the science that studies written and oral texts as the product of human mental processes. Studies in cognitive philology compare documentary evidence emerging from textual investigations with results of experimental research, especially in the fields of cognitive and ecological psychology, neurosciences and artificial intelligence. "The point is not the text, but the mind that made it". Cognitive Philology aims to foster communication between literary, textual, philological disciplines on the one hand and researches across the whole range of the cognitive, evolutionary, ecological and human sciences on the other. Cognitive philology: investigates transmission of oral and written text, and categorization processes which lead to classification of knowledge, mostly relying on the information theory; studies how narratives emerge in so called natural conversation and selective process which lead to the rise of literary standards for storytelling, mostly relying on embodied semantics; explores the evolutive and evolutionary role played by rhythm and metre in human ontogenetic and phylogenetic development and the pertinence of the semantic association during processing of cognitive maps; Provides the scientific ground for multimedia critical editions of literary texts. Among the founding thinkers and noteworthy scholars devoted to such investigations are: Alan Richardson: Studies Theory of Mind in early-modern and contemporary literature. Anatole Pierre Fuksas Benoît de Cornulier David Herman: Professor of English at North Carolina State University and an adjunct professor of linguistics at Duke University. He is the author of "Universal Grammar and Narrative Form" and the editor of "Narratologies: New Perspectives on Narrative Analysis". Domenico Fiormonte François Recanati Gilles Fauconnier, a professor in Cognitive science at the University of California, San Diego. He was one of the founders of cognitive linguistics in the 1970s through his work on pragmatic scales and mental spaces. His research explores the areas of conceptual integration and compressions of conceptual mappings in terms of the emergent structure in language. Julián Santano Moreno Luca Nobile Manfred Jahn in Germany Mark Turner Paolo Canettieri
POP-11
POP-11 is a reflective, incrementally compiled programming language with many of the features of an interpreted language. It is the core language of the Poplog programming environment developed originally by the University of Sussex, and recently in the School of Computer Science at the University of Birmingham, which hosts the main Poplog website. POP-11 is an evolution of the language POP-2, developed in Edinburgh University, and features an open stack model (like Forth, among others). It is mainly procedural, but supports declarative language constructs, including a pattern matcher, and is mostly used for research and teaching in artificial intelligence, although it has features sufficient for many other classes of problems. It is often used to introduce symbolic programming techniques to programmers of more conventional languages like Pascal, who find POP syntax more familiar than that of Lisp. One of POP-11's features is that it supports first-class functions. POP-11 is the core language of the Poplog system. The availability of the compiler and compiler subroutines at run-time (a requirement for incremental compiling) gives it the ability to support a far wider range of extensions (including run-time extensions, such as adding new data-types) than would be possible using only a macro facility. This made it possible for (optional) incremental compilers to be added for Prolog, Common Lisp and Standard ML, which could be added as required to support either mixed language development or development in the second language without using any POP-11 constructs. This made it possible for Poplog to be used by teachers, researchers, and developers who were interested in only one of the languages. The most successful product developed in POP-11 was the Clementine data mining system, developed by ISL. After SPSS bought ISL, they renamed Clementine to SPSS Modeler and decided to port it to C++ and Java, and eventually succeeded with great effort, and perhaps some loss of the flexibility provided by the use of an AI language. POP-11 was for a time available only as part of an expensive commercial package (Poplog), but since about 1999 it has been freely available as part of the open-source software version of Poplog, including various added packages and teaching libraries. An online version of ELIZA using POP-11 is available at Birmingham. At the University of Sussex, David Young used POP-11 in combination with C and Fortran to develop a suite of teaching and interactive development tools for image processing and vision, and has made them available in the Popvision extension to Poplog. == Simple code examples == Here is an example of a simple POP-11 program: define Double(Source) -> Result; Source2 -> Result; enddefine; Double(123) => That prints out: 246 This one includes some list processing: define RemoveElementsMatching(Element, Source) -> Result; lvars Index; [[% for Index in Source do unless Index = Element or Index matches Element then Index; endunless; endfor; %]] -> Result; enddefine; RemoveElementsMatching("the", [[the cat sat on the mat]]) => ;;; outputs [[cat sat on mat]] RemoveElementsMatching("the", [[the cat] [sat on] the mat]) => ;;; outputs [[the cat] [sat on] mat] RemoveElementsMatching([[= cat]], [[the cat]] is a [[big cat]]) => ;;; outputs [[is a]] Examples using the POP-11 pattern matcher, which makes it relatively easy for students to learn to develop sophisticated list-processing programs without having to treat patterns as tree structures accessed by 'head' and 'tail' functions (CAR and CDR in Lisp), can be found in the online introductory tutorial. The matcher is at the heart of the SimAgent (sim_agent) toolkit. Some of the powerful features of the toolkit, such as linking pattern variables to inline code variables, would have been very difficult to implement without the incremental compiler facilities.
Computational heuristic intelligence
Computational heuristic intelligence (CHI) refers to specialized programming techniques in computational intelligence (also called artificial intelligence, or AI). These techniques have the express goal of avoiding complexity issues, also called NP-hard problems, by using human-like techniques. They are best summarized as the use of exemplar-based methods (heuristics), rather than rule-based methods (algorithms). Hence the term is distinct from the more conventional computational algorithmic intelligence, or symbolic AI. An example of a CHI technique is the encoding specificity principle of Tulving and Thompson. In general, CHI principles are problem solving techniques used by people, rather than programmed into machines. It is by drawing attention to this key distinction that the use of this term is justified in a field already replete with confusing neologisms. Note that the legal systems of all modern human societies employ both heuristics (generalisations of cases) from individual trial records as well as legislated statutes (rules) as regulatory guides. Another recent approach to the avoidance of complexity issues is to employ feedback control rather than feedforward modeling as a problem-solving paradigm. This approach has been called computational cybernetics, because (a) the term 'computational' is associated with conventional computer programming techniques which represent a strategic, compiled, or feedforward model of the problem, and (b) the term 'cybernetic' is associated with conventional system operation techniques which represent a tactical, interpreted, or feedback model of the problem. Of course, real programs and real problems both contain both feedforward and feedback components. A real example which illustrates this point is that of human cognition, which clearly involves both perceptual (bottom-up, feedback, sensor-oriented) and conceptual (top-down, feedforward, motor-oriented) information flows and hierarchies. The AI engineer must choose between mathematical and cybernetic problem solution and machine design paradigms. This is not a coding (program language) issue, but relates to understanding the relationship between the declarative and procedural programming paradigms. The vast majority of STEM professionals never get the opportunity to design or implement pure cybernetic solutions. When pushed, most responders will dismiss the importance of any difference by saying that all code can be reduced to a mathematical model anyway. Unfortunately, not only is this belief false, it fails most spectacularly in many AI scenarios. Mathematical models are not time agnostic, but by their very nature are pre-computed, i.e. feedforward. Dyer [2012] and Feldman [2004] have independently investigated the simplest of all somatic governance paradigms, namely control of a simple jointed limb by a single flexor muscle. They found that it is impossible to determine forces from limb positions- therefore, the problem cannot have a pre-computed (feedforward) mathematical solution. Instead, a top-down command bias signal changes the threshold feedback level in the sensorimotor loop, e.g. the loop formed by the afferent and efferent nerves, thus changing the so-called ‘equilibrium point’ of the flexor muscle/ elbow joint system. An overview of the arrangement reveals that global postures and limb position are commanded in feedforward terms, using global displacements (common coding), with the forces needed being computed locally by feedback loops. This method of sensorimotor unit governance, which is based upon what Anatol Feldman calls the ‘equilibrium Point’ theory, is formally equivalent to a servomechanism such as a car's ‘cruise control’.
List of artificial intelligence journals
This is a list of notable peer-reviewed academic journals that publish research in the field of artificial intelligence (AI), including areas such as machine learning, computer vision, natural language processing, robotics, and intelligent systems. == General artificial intelligence == Artificial Intelligence (journal) – Elsevier Journal of Artificial Intelligence Research (JAIR) – AI Access Foundation Knowledge-Based Systems – Elsevier == Machine learning == Data Mining and Knowledge Discovery – Springer Machine Learning (journal) – Springer Journal of Machine Learning Research – Microtome Pattern Recognition (journal) – Elsevier Neural Networks (journal) – Elsevier Neural Computation (journal) – MIT Press Neurocomputing (journal) - Elsevier == Deep learning and neural computation == IEEE Transactions on Evolutionary Computation – IEEE IEEE Transactions on Neural Networks and Learning Systems – IEEE Nature Machine Intelligence – Springer Nature == Computer vision == International Journal of Computer Vision – Springer IEEE Transactions on Pattern Analysis and Machine Intelligence – IEEE Machine Vision and Applications – Springer == Natural language processing == Computational Linguistics (journal) – MIT Press Natural Language Processing Transactions of the Association for Computational Linguistics – ACL == Robotics and intelligent systems == IEEE Transactions on Robotics – IEEE Autonomous Robots – Springer Journal of Intelligent & Robotic Systems – Springer == Interdisciplinary and ethics in AI == AI & Society – Springer Artificial Life – MIT Press Philosophy & Technology – Springer Minds and Machines – Springer